La Jolla Pharmaceutical Co.. (LJPC) NASDAQ
$6.22 - (-)
Market Cap: -
As of 08/19/22 04:00 PM EDT. Market closed.
La Jolla Pharmaceutical Co.. (LJPC)
NASDAQ
$6.22
- (-)
Market Cap: -
As of 08/19/22 04:00 PM EDT. Market closed.
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La Jolla Pharmaceutical Company is dedicated to the development and commercialization of innovative therapies that improve outcomes in patients suffering from life-threatening diseases. In December 2017, GIAPREZA™ (angiotensin II) was approved by the U.S. Food and Drug Administration (FDA) as a vasoconstrictor indicated to increase blood pressure in adults with septic or other distributive ... read more
La Jolla Pharmaceutical Company is dedicated to the development and commercialization of innovative therapies that improve outcomes in patients suffering from life-threatening diseases. In December 2017, GIAPREZA™ (angiotensin II) was approved by the U.S. Food and Drug Administration (FDA) as a vasoconstrictor indicated to increase blood pressure in adults with septic or other distributive shock. In August 2019, GIAPREZA was approved by the European Commission (EC) for the treatment of refractory hypotension in adults with septic or other distributive shock who remain hypotensive despite adequate volume restitution and application of catecholamines and other available vasopressor therapies. LJPC-0118 (artesunate) is La Jolla's investigational product for the treatment of severe malaria. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Biological Product (except Diagnostic) Manufacturing
CEO Compensation (Base)
$589,000
CEO Compensation (Total)
$1.51M
Sector
Manufacturing
Industry
Biological Product (except Diagnostic) Manufacturing
Full Time Employees
59
CEO Compensation (Base)
$589,000
CEO Compensation (Total)
$1.51M
Address
4550 Towne Centre Ct, California, San Diego, 92121-1900.
PRICE CHART FOR LA JOLLA PHARMACEUTICAL CO.
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
-
Previous Close
$6.22
Days Range
$6.20 - $6.24
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
24,936,883
Open
-
Previous Close
$6.22
Days Range
$6.20 - $6.24
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
24,936,883
FINANCIAL STATEMENTS FOR LA JOLLA PHARMACEUTICAL CO.
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INSIDER TRANSACTIONS FOR LA JOLLA PHARMACEUTICAL CO.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| RAMSAY DAVID A | Director | Aug 22, 2022 | Option Exercise | $6.23 | 100,000 | 623,000 | 0 | Aug 24, 2022, 08:22 PM |
| TANG KEVIN C | Director | Aug 22, 2022 | Option Exercise | $6.23 | 9,607,934 | 59,857,429 | 0 | Aug 24, 2022, 08:21 PM |
| Edwards Larry G. | Chief Executive Officer | Aug 22, 2022 | Option Exercise | $6.23 | 11,969 | 74,567 | 0 | Aug 24, 2022, 08:20 PM |
| Johnson Laura L. | Director | Aug 22, 2022 | Option Exercise | $6.23 | 500 | 3,115 | 0 | Aug 24, 2022, 08:18 PM |
| Johnson Craig A | Director | Aug 22, 2022 | Option Exercise | $6.23 | 12,000 | 74,760 | 0 | Aug 24, 2022, 08:17 PM |
| Hearne Michael S | Chief Financial Officer | Aug 22, 2022 | Option Exercise | $6.23 | 10,186 | 63,459 | 0 | Aug 24, 2022, 08:17 PM |
| Hearne Michael S | Chief Financial Officer | Aug 22, 2022 | Option Exercise | $6.23 | 9,607,934 | 59,857,429 | 0 | Aug 24, 2022, 08:17 PM |
| TANG KEVIN C | Director | Aug 22, 2022 | Option Exercise | $6.23 | 9,607,934 | 59,857,429 | 0 | Aug 24, 2022, 04:02 PM |
| Johnson Craig A | Director | Jul 08, 2022 | Option Exercise | $3.93 | 12,000 | 47,160 | 12,000 | Jul 12, 2022, 08:36 PM |
| Hearne Michael S | Chief Financial Officer | Jun 30, 2022 | Option Exercise | $2.71 | 236 | 640 | 10,186 | Jul 05, 2022, 05:51 PM |
| Hearne Michael S | Chief Financial Officer | Jun 15, 2022 | Option Exercise | $2.72 | 236 | 642 | 9,950 | Jun 17, 2022, 05:05 PM |
| Hearne Michael S | Chief Financial Officer | May 31, 2022 | Option Exercise | $3.41 | 189 | 644 | 9,714 | Jun 02, 2022, 05:05 PM |
| Hearne Michael S | Chief Financial Officer | May 13, 2022 | Option Exercise | $3.41 | 188 | 641 | 9,525 | May 17, 2022, 05:07 PM |
| Hearne Michael S | Chief Financial Officer | Apr 29, 2022 | Option Exercise | $3.47 | 185 | 642 | 9,337 | May 03, 2022, 05:00 PM |
| Edwards Larry G. | Chief Executive Officer | Apr 14, 2022 | Option Exercise | $3.71 | 296 | 1,099 | 11,969 | Apr 18, 2022, 06:32 PM |
| Hearne Michael S | Chief Financial Officer | Apr 14, 2022 | Option Exercise | $3.71 | 173 | 643 | 9,152 | Apr 18, 2022, 06:31 PM |
| Edwards Larry G. | Chief Executive Officer | Mar 31, 2022 | Option Exercise | $3.63 | 334 | 1,212 | 11,673 | Apr 04, 2022, 05:39 PM |
| Hearne Michael S | Chief Financial Officer | Mar 31, 2022 | Option Exercise | $3.63 | 177 | 642 | 8,979 | Apr 04, 2022, 05:38 PM |
| Edwards Larry G. | Chief Executive Officer | Mar 15, 2022 | Option Exercise | $3.37 | 361 | 1,215 | 11,339 | Mar 17, 2022, 09:06 PM |
| Hearne Michael S | Chief Financial Officer | Mar 15, 2022 | Option Exercise | $3.37 | 190 | 640 | 8,802 | Mar 17, 2022, 09:04 PM |
| Edwards Larry G. | Chief Executive Officer | Feb 28, 2022 | Option Exercise | $3.48 | 350 | 1,217 | 10,978 | Mar 02, 2022, 05:08 PM |
| Hearne Michael S | Chief Financial Officer | Feb 28, 2022 | Option Exercise | $3.48 | 185 | 643 | 8,612 | Mar 02, 2022, 05:07 PM |
| Edwards Larry G. | Chief Executive Officer | Feb 15, 2022 | Option Exercise | $3.79 | 320 | 1,213 | 10,628 | Feb 17, 2022, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Feb 15, 2022 | Option Exercise | $3.79 | 169 | 641 | 8,427 | Feb 17, 2022, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Jan 31, 2022 | Option Exercise | $3.94 | 4,170 | 16,411 | 10,308 | Feb 02, 2022, 07:21 PM |
| Hearne Michael S | Chief Financial Officer | Jan 31, 2022 | Option Exercise | $3.94 | 1,675 | 6,592 | 8,258 | Feb 02, 2022, 07:19 PM |
| Edwards Larry G. | Chief Executive Officer | Jan 14, 2022 | Option Exercise | $4.18 | 273 | 1,142 | 6,138 | Jan 19, 2022, 08:27 PM |
| Hearne Michael S | Chief Financial Officer | Jan 14, 2022 | Option Exercise | $4.18 | 148 | 619 | 6,583 | Jan 19, 2022, 08:26 PM |
| Edwards Larry G. | Chief Executive Officer | Dec 30, 2021 | Option Exercise | $3.92 | 233 | 913 | 5,865 | Jan 04, 2022, 05:10 PM |
| Edwards Larry G. | Chief Executive Officer | Dec 15, 2021 | Option Exercise | $3.58 | 320 | 1,145 | 5,632 | Dec 17, 2021, 06:01 PM |
| Hearne Michael S | Chief Financial Officer | Dec 15, 2021 | Option Exercise | $3.58 | 173 | 619 | 6,278 | Dec 17, 2021, 05:58 PM |
| RAMSAY DAVID A | Director | Dec 06, 2021 | Buy | $3.82 | 10,000 | 38,231 | 100,000 | Dec 06, 2021, 09:01 PM |
| RAMSAY DAVID A | Director | Dec 03, 2021 | Buy | $3.66 | 4,399 | 16,082 | 90,000 | Dec 06, 2021, 09:01 PM |
| RAMSAY DAVID A | Director | Dec 02, 2021 | Buy | $3.73 | 10,101 | 37,677 | 85,601 | Dec 06, 2021, 09:01 PM |
| Edwards Larry G. | Chief Executive Officer | Nov 30, 2021 | Option Exercise | $3.32 | 346 | 1,147 | 5,312 | Dec 02, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Nov 30, 2021 | Option Exercise | $3.32 | 186 | 617 | 6,105 | Dec 02, 2021, 05:05 PM |
| TANG KEVIN C | Director | Nov 30, 2021 | Sale | $3.95 | 70,342 | 277,612 | 9,849,224 | Dec 01, 2021, 07:07 PM |
| TANG KEVIN C | Director | Nov 29, 2021 | Sale | $4.10 | 193,403 | 793,107 | 9,855,821 | Dec 01, 2021, 07:07 PM |
| TANG KEVIN C | Director | Dec 01, 2021 | Sale | $3.74 | 177,545 | 663,431 | 9,649,224 | Dec 01, 2021, 07:07 PM |
| RAMSAY DAVID A | Director | Nov 17, 2021 | Buy | $4.23 | 7,500 | 31,725 | 75,500 | Nov 19, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Nov 15, 2021 | Option Exercise | $3.41 | 336 | 1,145 | 4,966 | Nov 17, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Nov 15, 2021 | Option Exercise | $3.41 | 181 | 617 | 5,919 | Nov 17, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Oct 29, 2021 | Option Exercise | $3.42 | 335 | 1,145 | 4,630 | Nov 02, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Oct 29, 2021 | Option Exercise | $3.42 | 181 | 618 | 5,738 | Nov 02, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Oct 15, 2021 | Option Exercise | $3.37 | 341 | 1,148 | 4,295 | Oct 19, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Oct 15, 2021 | Option Exercise | $3.37 | 183 | 616 | 5,557 | Oct 19, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Sep 30, 2021 | Option Exercise | $3.39 | 338 | 1,146 | 3,954 | Oct 04, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Sep 30, 2021 | Option Exercise | $3.39 | 182 | 617 | 5,374 | Oct 04, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Sep 15, 2021 | Option Exercise | $3.39 | 338 | 1,146 | 3,616 | Sep 17, 2021, 05:05 PM |
| Hearne Michael S | Chief Financial Officer | Sep 15, 2021 | Option Exercise | $3.39 | 546 | 1,852 | 5,192 | Sep 17, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Aug 31, 2021 | Option Exercise | $3.58 | 320 | 1,145 | 3,278 | Sep 02, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Aug 13, 2021 | Option Exercise | $3.38 | 338 | 1,143 | 2,958 | Aug 17, 2021, 05:05 PM |
| Edwards Larry G. | Chief Executive Officer | Jul 30, 2021 | Option Exercise | $3.07 | 374 | 1,148 | 2,620 | Aug 03, 2021, 05:10 PM |
| Hearne Michael S | Chief Financial Officer | Jul 30, 2021 | Option Exercise | $3.07 | 201 | 617 | 4,646 | Aug 03, 2021, 05:05 PM |
| Hearne Michael S | Chief Financial Officer | Jul 15, 2021 | Option Exercise | $3.20 | 193 | 617 | 4,445 | Jul 19, 2021, 06:57 PM |
| Edwards Larry G. | Chief Executive Officer | Jul 15, 2021 | Option Exercise | $3.20 | 358 | 1,144 | 2,246 | Jul 19, 2021, 06:50 PM |
| Edwards Larry G. | Chief Executive Officer | Jun 30, 2021 | Option Exercise | $3.64 | 315 | 1,146 | 1,888 | Jul 02, 2021, 08:46 PM |
| Hearne Michael S | Chief Financial Officer | Jun 30, 2021 | Option Exercise | $3.64 | 170 | 618 | 4,252 | Jul 02, 2021, 08:35 PM |
| Edwards Larry G. | Chief Executive Officer | May 28, 2021 | Option Exercise | $3.65 | 314 | 1,148 | 1,298 | Jun 02, 2021, 05:07 PM |
| Edwards Larry G. | Chief Executive Officer | May 14, 2021 | Option Exercise | $3.20 | 358 | 1,144 | 984 | May 18, 2021, 08:29 PM |
| Hearne Michael S | Chief Financial Officer | May 14, 2021 | Option Exercise | $3.20 | 193 | 617 | 3,765 | May 18, 2021, 08:26 PM |
| Edwards Larry G. | Chief Executive Officer | Apr 15, 2021 | Option Exercise | $3.55 | 322 | 1,144 | 322 | Apr 19, 2021, 09:41 PM |
| Hearne Michael S | Chief Financial Officer | Apr 15, 2021 | Option Exercise | $3.55 | 173 | 615 | 3,835 | Apr 19, 2021, 09:38 PM |
| Hearne Michael S | Chief Financial Officer | Mar 15, 2021 | Option Exercise | $4.85 | 127 | 616 | 3,490 | Mar 17, 2021, 04:43 PM |
| Hearne Michael S | Chief Financial Officer | Feb 26, 2021 | Option Exercise | $4.45 | 139 | 619 | 3,363 | Mar 02, 2021, 04:36 PM |
| Hearne Michael S | Chief Financial Officer | Feb 12, 2021 | Option Exercise | $5.70 | 535 | 3,051 | 3,224 | Feb 18, 2021, 04:24 PM |
| Hearne Michael S | Chief Financial Officer | Jan 29, 2021 | Option Exercise | $5.20 | 118 | 614 | 2,689 | Feb 02, 2021, 05:21 PM |
| Hearne Michael S | Chief Financial Officer | Jan 15, 2021 | Option Exercise | $4.55 | 136 | 618 | 2,571 | Feb 02, 2021, 05:20 PM |
| Hearne Michael S | Chief Financial Officer | Dec 31, 2020 | Option Exercise | $3.30 | 1,648 | 5,435 | 2,435 | Feb 02, 2021, 05:18 PM |
| Hearne Michael S | Chief Financial Officer | Jan 15, 2021 | Option Exercise | $4.55 | 136 | 618 | 1,094 | Jan 20, 2021, 04:57 PM |
| Hearne Michael S | Chief Financial Officer | Dec 31, 2020 | Option Exercise | $3.30 | 171 | 564 | 958 | Jan 05, 2021, 04:32 PM |
| Hearne Michael S | Chief Financial Officer | Dec 15, 2020 | Option Exercise | $3.83 | 147 | 562 | 787 | Dec 16, 2020, 04:22 PM |
| Hearne Michael S | Chief Financial Officer | Nov 30, 2020 | Option Exercise | $4.22 | 134 | 566 | 640 | Dec 02, 2020, 04:21 PM |
| Hearne Michael S | Chief Financial Officer | Nov 13, 2020 | Option Exercise | $3.98 | 141 | 561 | 506 | Nov 17, 2020, 04:13 PM |
| Hearne Michael S | Chief Financial Officer | Oct 30, 2020 | Option Exercise | $2.89 | 196 | 566 | 365 | Nov 05, 2020, 04:59 PM |
| Hearne Michael S | Chief Financial Officer | Oct 15, 2020 | Option Exercise | $3.32 | 169 | 561 | 169 | Oct 19, 2020, 09:14 PM |
| Chawla Lakhmir S | Chief Medical Officer | Sep 15, 2020 | Option Exercise | $3.85 | 286 | 1,101 | 13,447 | Sep 17, 2020, 04:57 PM |
| RAMSAY DAVID A | Director | Sep 08, 2020 | Buy | $3.83 | 1,000 | 3,830 | 48,000 | Sep 10, 2020, 04:02 PM |
| TANG KEVIN C | Director | Sep 09, 2020 | Buy | $4.03 | 126,665 | 509,940 | 9,405,490 | Sep 09, 2020, 06:55 PM |
| TANG KEVIN C | Director | Sep 08, 2020 | Buy | $3.90 | 84,152 | 328,529 | 9,278,825 | Sep 09, 2020, 06:55 PM |
| TANG KEVIN C | Director | Sep 04, 2020 | Buy | $3.82 | 67,552 | 258,359 | 9,194,673 | Sep 09, 2020, 06:55 PM |
| Chawla Lakhmir S | Chief Medical Officer | Aug 31, 2020 | Option Exercise | $3.57 | 550 | 1,963 | 13,161 | Sep 02, 2020, 04:17 PM |
| RAMSAY DAVID A | Director | Aug 24, 2020 | Buy | $3.76 | 7,000 | 26,289 | 47,000 | Aug 24, 2020, 04:22 PM |
| RAMSAY DAVID A | Director | Aug 21, 2020 | Buy | $3.97 | 28,000 | 111,108 | 40,000 | Aug 24, 2020, 04:22 PM |
| RAMSAY DAVID A | Director | Aug 20, 2020 | Buy | $4.17 | 12,000 | 50,060 | 12,000 | Aug 24, 2020, 04:22 PM |
| Chawla Lakhmir S | Chief Medical Officer | Aug 14, 2020 | Option Exercise | $3.34 | 589 | 1,967 | 12,611 | Aug 18, 2020, 05:18 PM |
| TANG KEVIN C | Director | Aug 14, 2020 | Buy | $3.88 | 168,669 | 653,694 | 9,127,121 | Aug 14, 2020, 04:49 PM |
| TANG KEVIN C | Director | Aug 13, 2020 | Buy | $3.65 | 219,465 | 800,586 | 8,958,452 | Aug 14, 2020, 04:49 PM |
| TANG KEVIN C | Director | Aug 12, 2020 | Buy | $3.47 | 43,513 | 150,820 | 8,738,987 | Aug 14, 2020, 04:49 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jul 31, 2020 | Option Exercise | $3.38 | 581 | 1,964 | 12,022 | Aug 04, 2020, 05:24 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jul 15, 2020 | Option Exercise | $3.77 | 521 | 1,964 | 11,441 | Jul 17, 2020, 04:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jun 30, 2020 | Option Exercise | $3.62 | 543 | 1,966 | 10,920 | Jul 01, 2020, 07:08 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jun 15, 2020 | Option Exercise | $4.51 | 435 | 1,962 | 10,377 | Jun 17, 2020, 06:26 PM |
| TANG KEVIN C | Director | Jun 04, 2020 | Buy | $4.94 | 215,812 | 1,065,636 | 8,695,474 | Jun 04, 2020, 06:26 PM |
| TANG KEVIN C | Director | Jun 03, 2020 | Buy | $4.90 | 145,764 | 714,783 | 8,479,662 | Jun 04, 2020, 06:26 PM |
| TANG KEVIN C | Director | Jun 02, 2020 | Buy | $4.88 | 253,553 | 1,237,060 | 8,333,898 | Jun 04, 2020, 06:26 PM |
| MULROY DENNIS | Chief Financial Officer | May 29, 2020 | Option Exercise | $4.01 | 82 | 329 | 5,067 | Jun 02, 2020, 04:03 PM |
| Chawla Lakhmir S | Chief Medical Officer | May 29, 2020 | Option Exercise | $4.01 | 491 | 1,969 | 9,942 | Jun 02, 2020, 04:02 PM |
| Rolke James | Chief Scientific Officer | May 29, 2020 | Option Exercise | $4.01 | 205 | 822 | 81,771 | Jun 02, 2020, 04:02 PM |
| MULROY DENNIS | Chief Financial Officer | May 15, 2020 | Option Exercise | $5.86 | 56 | 328 | 4,985 | May 19, 2020, 04:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | May 15, 2020 | Option Exercise | $5.86 | 335 | 1,963 | 9,451 | May 19, 2020, 04:05 PM |
| Rolke James | Chief Scientific Officer | May 15, 2020 | Option Exercise | $5.86 | 140 | 820 | 81,566 | May 19, 2020, 04:05 PM |
| Rolke James | Chief Scientific Officer | Apr 30, 2020 | Option Exercise | $6.17 | 133 | 821 | 81,426 | May 04, 2020, 04:09 PM |
| Chawla Lakhmir S | Chief Medical Officer | Apr 30, 2020 | Option Exercise | $6.17 | 319 | 1,968 | 9,116 | May 04, 2020, 04:09 PM |
| MULROY DENNIS | Chief Financial Officer | Apr 30, 2020 | Option Exercise | $6.17 | 53 | 327 | 4,929 | May 04, 2020, 04:08 PM |
| MULROY DENNIS | Chief Financial Officer | Apr 15, 2020 | Option Exercise | $5.61 | 58 | 325 | 4,876 | Apr 17, 2020, 04:03 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Apr 15, 2020 | Option Exercise | $5.61 | 34 | 191 | 9,504 | Apr 17, 2020, 04:03 PM |
| Chawla Lakhmir S | Chief Medical Officer | Apr 15, 2020 | Option Exercise | $5.61 | 350 | 1,964 | 8,797 | Apr 17, 2020, 04:02 PM |
| Rolke James | Chief Scientific Officer | Apr 15, 2020 | Option Exercise | $5.61 | 146 | 819 | 81,293 | Apr 17, 2020, 04:02 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 31, 2020 | Option Exercise | $3.57 | 165 | 589 | 8,447 | Apr 02, 2020, 06:08 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Mar 31, 2020 | Option Exercise | $3.57 | 459 | 1,639 | 9,470 | Apr 02, 2020, 06:08 PM |
| Rolke James | Chief Scientific Officer | Mar 31, 2020 | Option Exercise | $3.57 | 229 | 818 | 81,147 | Apr 02, 2020, 06:08 PM |
| Rolke James | Chief Scientific Officer | Mar 13, 2020 | Option Exercise | $3.40 | 241 | 819 | 80,918 | Mar 16, 2020, 04:13 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Mar 13, 2020 | Option Exercise | $3.40 | 483 | 1,642 | 9,011 | Mar 16, 2020, 04:13 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 13, 2020 | Option Exercise | $3.40 | 173 | 588 | 8,282 | Mar 16, 2020, 04:12 PM |
| Rolke James | Chief Scientific Officer | Feb 28, 2020 | Option Exercise | $5.78 | 142 | 821 | 80,677 | Mar 03, 2020, 04:14 PM |
| Chawla Lakhmir S | Chief Medical Officer | Feb 28, 2020 | Option Exercise | $5.78 | 102 | 590 | 8,109 | Mar 03, 2020, 04:14 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Feb 28, 2020 | Option Exercise | $5.78 | 284 | 1,642 | 8,528 | Mar 03, 2020, 04:13 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Feb 14, 2020 | Option Exercise | $7.14 | 229 | 1,635 | 8,244 | Feb 19, 2020, 04:48 PM |
| Chawla Lakhmir S | Chief Medical Officer | Feb 14, 2020 | Option Exercise | $7.14 | 83 | 593 | 8,007 | Feb 19, 2020, 04:48 PM |
| Rolke James | Chief Scientific Officer | Feb 14, 2020 | Option Exercise | $7.14 | 115 | 821 | 80,535 | Feb 19, 2020, 04:47 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 31, 2020 | Option Exercise | $5.82 | 101 | 588 | 7,924 | Feb 04, 2020, 04:02 PM |
| Rolke James | Chief Scientific Officer | Jan 31, 2020 | Option Exercise | $5.82 | 141 | 821 | 80,420 | Feb 04, 2020, 04:01 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jan 31, 2020 | Option Exercise | $5.82 | 282 | 1,641 | 8,015 | Feb 04, 2020, 12:00 AM |
| TANG KEVIN C | Director | Feb 03, 2020 | Buy | $6.80 | 75,003 | 509,833 | 8,080,345 | Feb 03, 2020, 05:02 PM |
| TANG KEVIN C | Director | Jan 31, 2020 | Buy | $6.75 | 13,292 | 89,705 | 8,005,342 | Feb 03, 2020, 05:02 PM |
| TANG KEVIN C | Director | Jan 30, 2020 | Buy | $6.72 | 81,475 | 547,431 | 7,992,050 | Feb 03, 2020, 05:02 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jan 15, 2020 | Option Exercise | $6.70 | 1,188 | 7,960 | 7,733 | Jan 17, 2020, 04:14 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 15, 2020 | Option Exercise | $6.70 | 498 | 3,337 | 7,823 | Jan 17, 2020, 04:14 PM |
| Rolke James | Chief Scientific Officer | Jan 15, 2020 | Option Exercise | $6.70 | 692 | 4,636 | 80,279 | Jan 17, 2020, 04:13 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jan 14, 2020 | Buy | $8.23 | 3,000 | 24,677 | 6,545 | Jan 16, 2020, 04:05 PM |
| TANG KEVIN C | Director | Jan 13, 2020 | Buy | $6.66 | 1,253,878 | 8,351,580 | 7,910,575 | Jan 13, 2020, 05:59 PM |
| TANG KEVIN C | Director | Jan 10, 2020 | Buy | $5.70 | 717,804 | 4,090,909 | 6,656,697 | Jan 13, 2020, 05:59 PM |
| TANG KEVIN C | Director | Jan 09, 2020 | Buy | $4.99 | 1,000,000 | 4,991,980 | 5,938,893 | Jan 13, 2020, 05:59 PM |
| Chawla Lakhmir S | Chief Medical Officer | Dec 31, 2019 | Option Exercise | $3.34 | 172 | 574 | 7,325 | Jan 03, 2020, 04:34 PM |
| MULROY DENNIS | Chief Financial Officer | Dec 31, 2019 | Option Exercise | $3.34 | 16 | 53 | 4,818 | Jan 03, 2020, 12:00 AM |
| MULROY DENNIS | Chief Financial Officer | Dec 13, 2019 | Option Exercise | $2.85 | 112 | 319 | 4,802 | Dec 17, 2019, 04:03 PM |
| Chawla Lakhmir S | Chief Medical Officer | Dec 13, 2019 | Option Exercise | $2.85 | 201 | 573 | 7,153 | Dec 17, 2019, 04:03 PM |
| Chawla Lakhmir S | Chief Medical Officer | Nov 29, 2019 | Option Exercise | $2.33 | 247 | 576 | 6,952 | Dec 03, 2019, 04:28 PM |
| MULROY DENNIS | Chief Financial Officer | Nov 29, 2019 | Option Exercise | $2.33 | 138 | 322 | 4,690 | Dec 03, 2019, 04:27 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Nov 29, 2019 | Option Exercise | $2.33 | 17 | 40 | 3,545 | Dec 03, 2019, 04:27 PM |
| Rolke James | Chief Scientific Officer | Nov 15, 2019 | Option Exercise | $5.12 | 118 | 604 | 79,587 | Nov 19, 2019, 04:12 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Nov 15, 2019 | Option Exercise | $5.12 | 311 | 1,592 | 3,528 | Nov 19, 2019, 04:12 PM |
| MULROY DENNIS | Chief Financial Officer | Nov 15, 2019 | Option Exercise | $5.12 | 62 | 317 | 4,552 | Nov 19, 2019, 04:11 PM |
| Chawla Lakhmir S | Chief Medical Officer | Nov 15, 2019 | Option Exercise | $5.12 | 111 | 568 | 6,705 | Nov 19, 2019, 04:11 PM |
| Rolke James | Chief Scientific Officer | Oct 31, 2019 | Option Exercise | $5.96 | 133 | 793 | 79,469 | Nov 05, 2019, 04:06 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Oct 31, 2019 | Option Exercise | $5.96 | 267 | 1,591 | 3,217 | Nov 05, 2019, 04:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | Oct 31, 2019 | Option Exercise | $5.96 | 96 | 572 | 6,594 | Nov 05, 2019, 04:05 PM |
| MULROY DENNIS | Chief Financial Officer | Oct 31, 2019 | Option Exercise | $5.96 | 267 | 1,591 | 4,490 | Nov 05, 2019, 04:04 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Oct 15, 2019 | Option Exercise | $7.12 | 224 | 1,595 | 2,950 | Oct 17, 2019, 05:42 PM |
| Chawla Lakhmir S | Chief Medical Officer | Oct 15, 2019 | Option Exercise | $7.12 | 81 | 577 | 6,498 | Oct 17, 2019, 05:41 PM |
| MULROY DENNIS | Chief Financial Officer | Oct 15, 2019 | Option Exercise | $7.12 | 224 | 1,595 | 4,223 | Oct 17, 2019, 05:41 PM |
| Rolke James | Chief Scientific Officer | Oct 15, 2019 | Option Exercise | $7.12 | 112 | 797 | 79,336 | Oct 17, 2019, 05:40 PM |
| Rolke James | Chief Scientific Officer | Sep 30, 2019 | Option Exercise | $7.48 | 107 | 800 | 79,224 | Oct 02, 2019, 05:06 PM |
| MULROY DENNIS | Chief Financial Officer | Sep 30, 2019 | Option Exercise | $7.48 | 213 | 1,593 | 3,999 | Oct 02, 2019, 05:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | Sep 30, 2019 | Option Exercise | $7.48 | 76 | 568 | 6,417 | Oct 02, 2019, 05:05 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Sep 30, 2019 | Option Exercise | $7.48 | 213 | 1,593 | 2,726 | Oct 02, 2019, 05:04 PM |
| Rolke James | Chief Scientific Officer | Sep 13, 2019 | Option Exercise | $9.28 | 85 | 789 | 79,117 | Sep 16, 2019, 07:24 PM |
| MULROY DENNIS | Chief Financial Officer | Sep 13, 2019 | Option Exercise | $9.28 | 171 | 1,587 | 3,786 | Sep 16, 2019, 07:24 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Sep 13, 2019 | Option Exercise | $9.28 | 171 | 1,587 | 2,513 | Sep 16, 2019, 07:24 PM |
| Chawla Lakhmir S | Chief Medical Officer | Sep 13, 2019 | Option Exercise | $9.28 | 62 | 575 | 6,341 | Sep 16, 2019, 07:23 PM |
| MULROY DENNIS | Chief Financial Officer | Aug 30, 2019 | Option Exercise | $8.13 | 196 | 1,593 | 3,615 | Sep 03, 2019, 04:13 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Aug 30, 2019 | Option Exercise | $8.13 | 196 | 1,593 | 2,342 | Sep 03, 2019, 04:12 PM |
| Chawla Lakhmir S | Chief Medical Officer | Aug 30, 2019 | Option Exercise | $8.13 | 70 | 569 | 6,279 | Sep 03, 2019, 04:12 PM |
| Rolke James | Chief Scientific Officer | Aug 30, 2019 | Option Exercise | $8.13 | 98 | 797 | 79,032 | Sep 03, 2019, 04:12 PM |
| Rolke James | Chief Scientific Officer | Aug 15, 2019 | Option Exercise | $8.02 | 99 | 794 | 78,934 | Aug 16, 2019, 04:51 PM |
| Chawla Lakhmir S | Chief Medical Officer | Aug 15, 2019 | Option Exercise | $8.02 | 72 | 577 | 6,209 | Aug 16, 2019, 04:51 PM |
| MULROY DENNIS | Chief Financial Officer | Aug 15, 2019 | Option Exercise | $8.02 | 198 | 1,588 | 3,419 | Aug 16, 2019, 04:50 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Aug 15, 2019 | Option Exercise | $8.02 | 198 | 1,588 | 2,146 | Aug 16, 2019, 04:50 PM |
| MULROY DENNIS | Chief Financial Officer | Jul 31, 2019 | Option Exercise | $7.11 | 224 | 1,593 | 3,221 | Aug 02, 2019, 04:59 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jul 31, 2019 | Option Exercise | $7.11 | 80 | 569 | 6,137 | Aug 02, 2019, 04:59 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jul 31, 2019 | Option Exercise | $7.11 | 224 | 1,593 | 1,948 | Aug 02, 2019, 04:59 PM |
| Rolke James | Chief Scientific Officer | Jul 31, 2019 | Option Exercise | $7.11 | 112 | 796 | 78,835 | Aug 02, 2019, 04:59 PM |
| MULROY DENNIS | Chief Financial Officer | Jul 15, 2019 | Option Exercise | $7.85 | 203 | 1,594 | 2,997 | Jul 17, 2019, 05:11 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jul 15, 2019 | Option Exercise | $7.85 | 203 | 1,594 | 1,724 | Jul 17, 2019, 05:10 PM |
| Rolke James | Chief Scientific Officer | Jul 15, 2019 | Option Exercise | $7.85 | 102 | 801 | 78,723 | Jul 17, 2019, 05:10 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jul 15, 2019 | Option Exercise | $7.85 | 73 | 573 | 6,057 | Jul 17, 2019, 05:10 PM |
| MULROY DENNIS | Chief Financial Officer | Jun 28, 2019 | Option Exercise | $7.86 | 202 | 1,588 | 2,794 | Jul 01, 2019, 06:12 PM |
| Rolke James | Chief Scientific Officer | Jun 28, 2019 | Option Exercise | $7.86 | 101 | 794 | 78,621 | Jul 01, 2019, 06:11 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jun 28, 2019 | Option Exercise | $7.86 | 202 | 1,588 | 1,521 | Jul 01, 2019, 06:11 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jun 28, 2019 | Option Exercise | $7.86 | 73 | 574 | 5,984 | Jul 01, 2019, 06:11 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Jun 14, 2019 | Option Exercise | $8.25 | 193 | 1,592 | 1,319 | Jun 18, 2019, 04:45 PM |
| MULROY DENNIS | Chief Financial Officer | Jun 14, 2019 | Option Exercise | $8.25 | 193 | 1,592 | 2,592 | Jun 18, 2019, 04:44 PM |
| Rolke James | Chief Scientific Officer | Jun 14, 2019 | Option Exercise | $8.25 | 96 | 792 | 78,520 | Jun 18, 2019, 04:44 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jun 14, 2019 | Option Exercise | $8.25 | 69 | 569 | 5,911 | Jun 18, 2019, 04:44 PM |
| Chawla Lakhmir S | Chief Medical Officer | May 31, 2019 | Option Exercise | $4.58 | 126 | 577 | 5,842 | Jun 03, 2019, 07:27 PM |
| Rolke James | Chief Scientific Officer | May 31, 2019 | Option Exercise | $4.58 | 174 | 797 | 78,424 | Jun 03, 2019, 07:27 PM |
| Wellinghoff Darryl | Chief Commercial Officer | May 31, 2019 | Option Exercise | $4.58 | 347 | 1,589 | 1,126 | Jun 03, 2019, 07:26 PM |
| MULROY DENNIS | Chief Financial Officer | May 31, 2019 | Option Exercise | $4.58 | 347 | 1,589 | 2,399 | Jun 03, 2019, 07:26 PM |
| Rolke James | Chief Scientific Officer | May 15, 2019 | Option Exercise | $5.58 | 143 | 798 | 78,250 | May 17, 2019, 04:07 PM |
| Wellinghoff Darryl | Chief Commercial Officer | May 15, 2019 | Option Exercise | $5.58 | 285 | 1,590 | 779 | May 17, 2019, 04:07 PM |
| Chawla Lakhmir S | Chief Medical Officer | May 15, 2019 | Option Exercise | $5.58 | 102 | 569 | 5,716 | May 17, 2019, 04:06 PM |
| MULROY DENNIS | Chief Financial Officer | May 15, 2019 | Option Exercise | $5.58 | 285 | 1,590 | 2,052 | May 17, 2019, 04:06 PM |
| MULROY DENNIS | Chief Financial Officer | Apr 30, 2019 | Option Exercise | $6.84 | 233 | 1,594 | 1,767 | May 02, 2019, 05:12 PM |
| Rolke James | Chief Scientific Officer | Apr 30, 2019 | Option Exercise | $6.84 | 116 | 793 | 78,107 | May 02, 2019, 05:11 PM |
| Chawla Lakhmir S | Chief Medical Officer | Apr 30, 2019 | Option Exercise | $6.84 | 84 | 575 | 5,614 | May 02, 2019, 05:11 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Apr 30, 2019 | Option Exercise | $6.84 | 233 | 1,594 | 494 | May 02, 2019, 05:10 PM |
| Chawla Lakhmir S | Chief Medical Officer | Apr 15, 2019 | Option Exercise | $6.09 | 94 | 572 | 5,530 | Apr 17, 2019, 05:05 PM |
| Wellinghoff Darryl | Chief Commercial Officer | Apr 15, 2019 | Option Exercise | $6.09 | 261 | 1,589 | 261 | Apr 17, 2019, 05:05 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Apr 15, 2019 | Option Exercise | $6.09 | 2 | 12 | 1,263,895 | Apr 17, 2019, 05:04 PM |
| MULROY DENNIS | Chief Financial Officer | Apr 15, 2019 | Option Exercise | $6.09 | 261 | 1,589 | 1,534 | Apr 17, 2019, 05:02 PM |
| Rolke James | Chief Scientific Officer | Apr 15, 2019 | Option Exercise | $6.09 | 131 | 798 | 77,991 | Apr 17, 2019, 05:01 PM |
| Rolke James | Chief Scientific Officer | Mar 29, 2019 | Option Exercise | $5.47 | 146 | 799 | 77,860 | Apr 02, 2019, 07:08 PM |
| MULROY DENNIS | Chief Financial Officer | Mar 29, 2019 | Option Exercise | $5.47 | 59 | 323 | 1,273 | Apr 02, 2019, 07:07 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 29, 2019 | Option Exercise | $5.47 | 94 | 514 | 1,263,893 | Apr 02, 2019, 07:07 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 29, 2019 | Option Exercise | $5.47 | 35 | 191 | 5,436 | Apr 02, 2019, 07:06 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 15, 2019 | Option Exercise | $6.49 | 195 | 1,266 | 1,263,799 | Mar 19, 2019, 05:08 PM |
| Rolke James | Chief Scientific Officer | Mar 15, 2019 | Option Exercise | $6.49 | 122 | 792 | 77,714 | Mar 19, 2019, 05:07 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 15, 2019 | Option Exercise | $6.49 | 29 | 188 | 5,401 | Mar 19, 2019, 05:06 PM |
| MULROY DENNIS | Chief Financial Officer | Mar 15, 2019 | Option Exercise | $6.49 | 49 | 318 | 1,214 | Mar 19, 2019, 04:49 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Feb 28, 2019 | Option Exercise | $4.85 | 261 | 1,266 | 1,263,604 | Mar 04, 2019, 05:33 PM |
| Rolke James | Chief Scientific Officer | Feb 28, 2019 | Option Exercise | $4.85 | 164 | 795 | 77,592 | Mar 04, 2019, 05:32 PM |
| MULROY DENNIS | Chief Financial Officer | Feb 28, 2019 | Option Exercise | $4.85 | 65 | 315 | 1,165 | Mar 04, 2019, 05:32 PM |
| Chawla Lakhmir S | Chief Medical Officer | Feb 28, 2019 | Option Exercise | $4.85 | 40 | 194 | 5,372 | Mar 04, 2019, 05:31 PM |
| CARVER JENNIFER | Chief Operating Officer | Feb 28, 2019 | Option Exercise | $4.85 | 230 | 1,115 | 14,049 | Mar 04, 2019, 05:30 PM |
| Chawla Lakhmir S | Chief Medical Officer | Feb 15, 2019 | Option Exercise | $5.30 | 36 | 191 | 5,332 | Feb 19, 2019, 06:12 PM |
| MULROY DENNIS | Chief Financial Officer | Feb 15, 2019 | Option Exercise | $5.30 | 60 | 318 | 1,100 | Feb 19, 2019, 06:11 PM |
| CARVER JENNIFER | Chief Operating Officer | Feb 15, 2019 | Option Exercise | $5.30 | 230 | 1,219 | 13,819 | Feb 19, 2019, 06:11 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Feb 15, 2019 | Option Exercise | $5.30 | 239 | 1,267 | 1,263,343 | Feb 19, 2019, 06:10 PM |
| Rolke James | Chief Scientific Officer | Feb 15, 2019 | Option Exercise | $5.30 | 151 | 800 | 77,428 | Feb 19, 2019, 06:10 PM |
| CARVER JENNIFER | Chief Operating Officer | Jan 31, 2019 | Option Exercise | $5.13 | 1,260 | 6,464 | 13,589 | Feb 04, 2019, 06:14 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Jan 31, 2019 | Option Exercise | $5.13 | 246 | 1,262 | 1,284,446 | Feb 04, 2019, 06:13 PM |
| MULROY DENNIS | Chief Financial Officer | Jan 31, 2019 | Option Exercise | $5.13 | 63 | 323 | 1,040 | Feb 04, 2019, 06:13 PM |
| Rolke James | Chief Scientific Officer | Jan 31, 2019 | Option Exercise | $5.13 | 155 | 795 | 77,277 | Feb 04, 2019, 06:12 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 31, 2019 | Option Exercise | $5.13 | 37 | 190 | 5,296 | Feb 04, 2019, 06:12 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 30, 2019 | Buy | $5.57 | 1,000 | 5,570 | 5,259 | Jan 31, 2019, 06:49 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 29, 2019 | Buy | $5.56 | 2,000 | 11,124 | 4,259 | Jan 31, 2019, 06:49 PM |
| CARVER JENNIFER | Chief Operating Officer | Jan 15, 2019 | Option Exercise | $5.74 | 213 | 1,223 | 12,329 | Jan 17, 2019, 08:54 PM |
| MULROY DENNIS | Chief Financial Officer | Jan 15, 2019 | Option Exercise | $5.74 | 316 | 1,814 | 977 | Jan 17, 2019, 08:54 PM |
| Chawla Lakhmir S | Chief Medical Officer | Jan 15, 2019 | Option Exercise | $5.74 | 72 | 413 | 2,259 | Jan 17, 2019, 08:53 PM |
| Rolke James | Chief Scientific Officer | Jan 15, 2019 | Option Exercise | $5.74 | 792 | 4,546 | 77,122 | Jan 17, 2019, 08:52 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Jan 15, 2019 | Option Exercise | $5.74 | 874 | 5,017 | 1,284,200 | Jan 17, 2019, 08:52 PM |
| TANG KEVIN C | Director | Jan 09, 2019 | Buy | $5.54 | 79,214 | 438,806 | 4,938,893 | Jan 09, 2019, 09:54 PM |
| TANG KEVIN C | Director | Jan 08, 2019 | Buy | $5.32 | 1,120,786 | 5,962,639 | 4,859,679 | Jan 09, 2019, 09:54 PM |
| TANG KEVIN C | Director | Jan 07, 2019 | Buy | $5.84 | 100,000 | 583,840 | 3,738,893 | Jan 09, 2019, 09:54 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Jan 07, 2019 | Buy | $5.85 | 2,000 | 11,700 | 1,283,326 | Jan 09, 2019, 09:29 PM |
| CARVER JENNIFER | Chief Operating Officer | Jan 09, 2019 | Buy | $6.17 | 5,000 | 30,825 | 12,116 | Jan 09, 2019, 09:29 PM |
| Rolke James | Chief Scientific Officer | Jan 09, 2019 | Buy | $6.09 | 1,600 | 9,746 | 76,330 | Jan 09, 2019, 09:28 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Jan 08, 2019 | Sale | $5.25 | 1,250,235 | 6,568,236 | 2,703,611 | Jan 09, 2019, 07:37 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Jan 07, 2019 | Sale | $6.36 | 810,000 | 5,147,749 | 3,881,967 | Jan 09, 2019, 07:37 PM |
| Chawla Lakhmir S | Chief Medical Officer | Dec 31, 2018 | Option Exercise | $8.02 | 23 | 184 | 2,187 | Jan 03, 2019, 07:53 PM |
| Rolke James | Chief Scientific Officer | Dec 31, 2018 | Option Exercise | $8.02 | 97 | 778 | 74,730 | Jan 03, 2019, 07:53 PM |
| MULROY DENNIS | Chief Financial Officer | Dec 31, 2018 | Option Exercise | $8.02 | 39 | 313 | 661 | Jan 03, 2019, 07:52 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Dec 31, 2018 | Option Exercise | $8.02 | 154 | 1,234 | 1,281,326 | Jan 03, 2019, 07:51 PM |
| CARVER JENNIFER | Chief Operating Officer | Dec 31, 2018 | Option Exercise | $8.02 | 148 | 1,186 | 7,116 | Jan 03, 2019, 07:51 PM |
| Chawla Lakhmir S | Chief Medical Officer | Dec 14, 2018 | Option Exercise | $10.88 | 17 | 185 | 2,164 | Dec 17, 2018, 08:30 PM |
| MULROY DENNIS | Chief Financial Officer | Dec 14, 2018 | Option Exercise | $10.88 | 28 | 305 | 622 | Dec 17, 2018, 08:29 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Dec 14, 2018 | Option Exercise | $10.88 | 112 | 1,219 | 1,281,172 | Dec 17, 2018, 08:28 PM |
| Rolke James | Chief Scientific Officer | Dec 14, 2018 | Option Exercise | $10.88 | 70 | 762 | 74,633 | Dec 17, 2018, 08:28 PM |
| CARVER JENNIFER | Chief Operating Officer | Dec 14, 2018 | Option Exercise | $10.88 | 108 | 1,175 | 6,968 | Dec 17, 2018, 08:27 PM |
| MULROY DENNIS | Chief Financial Officer | Nov 30, 2018 | Option Exercise | $12.30 | 26 | 320 | 594 | Dec 03, 2018, 09:57 PM |
| Rolke James | Chief Scientific Officer | Nov 30, 2018 | Option Exercise | $12.30 | 63 | 775 | 74,563 | Dec 03, 2018, 09:56 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Nov 30, 2018 | Option Exercise | $12.30 | 100 | 1,230 | 1,281,060 | Dec 03, 2018, 09:56 PM |
| Chawla Lakhmir S | Chief Medical Officer | Nov 30, 2018 | Option Exercise | $12.30 | 16 | 197 | 2,147 | Dec 03, 2018, 09:56 PM |
| CARVER JENNIFER | Chief Operating Officer | Nov 30, 2018 | Option Exercise | $12.30 | 96 | 1,181 | 6,860 | Dec 03, 2018, 09:55 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Nov 15, 2018 | Option Exercise | $12.66 | 97 | 1,229 | 1,280,960 | Nov 19, 2018, 05:06 PM |
| Rolke James | Chief Scientific Officer | Nov 15, 2018 | Option Exercise | $12.66 | 61 | 773 | 74,500 | Nov 19, 2018, 05:06 PM |
| MULROY DENNIS | Chief Financial Officer | Nov 15, 2018 | Option Exercise | $12.66 | 24 | 304 | 568 | Nov 19, 2018, 05:05 PM |
| CARVER JENNIFER | Chief Operating Officer | Nov 15, 2018 | Option Exercise | $12.66 | 94 | 1,191 | 6,764 | Nov 19, 2018, 05:05 PM |
| Chawla Lakhmir S | Chief Medical Officer | Nov 15, 2018 | Option Exercise | $12.66 | 16 | 203 | 2,131 | Nov 19, 2018, 05:04 PM |
| Rolke James | Chief Scientific Officer | Oct 31, 2018 | Option Exercise | $13.85 | 56 | 776 | 74,439 | Nov 01, 2018, 08:43 PM |
| CARVER JENNIFER | Chief Operating Officer | Oct 31, 2018 | Option Exercise | $13.85 | 85 | 1,178 | 6,670 | Nov 01, 2018, 08:42 PM |
| Chawla Lakhmir S | Chief Medical Officer | Oct 31, 2018 | Option Exercise | $13.85 | 15 | 208 | 2,115 | Nov 01, 2018, 08:42 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Oct 31, 2018 | Option Exercise | $13.85 | 89 | 1,233 | 1,280,863 | Nov 01, 2018, 08:41 PM |
| MULROY DENNIS | Chief Financial Officer | Oct 31, 2018 | Option Exercise | $13.85 | 22 | 305 | 544 | Nov 01, 2018, 08:40 PM |
| MULROY DENNIS | Chief Financial Officer | Oct 15, 2018 | Option Exercise | $13.81 | 22 | 304 | 522 | Oct 15, 2018, 08:53 PM |
| Chawla Lakhmir S | Chief Medical Officer | Oct 15, 2018 | Option Exercise | $13.81 | 15 | 207 | 2,100 | Oct 15, 2018, 08:53 PM |
| Rolke James | Chief Scientific Officer | Oct 15, 2018 | Option Exercise | $13.81 | 55 | 760 | 74,383 | Oct 15, 2018, 08:52 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Oct 15, 2018 | Option Exercise | $13.81 | 88 | 1,215 | 1,280,774 | Oct 15, 2018, 08:52 PM |
| CARVER JENNIFER | Chief Operating Officer | Oct 15, 2018 | Option Exercise | $13.81 | 85 | 1,174 | 6,585 | Oct 15, 2018, 08:51 PM |
| Rolke James | Chief Scientific Officer | Aug 16, 2018 | Buy | $22.00 | 1,000 | 21,997 | 74,328 | Aug 20, 2018, 09:06 PM |
| CARVER JENNIFER | Chief Operating Officer | Aug 16, 2018 | Buy | $20.90 | 1,000 | 20,895 | 6,500 | Aug 20, 2018, 09:05 PM |
| Douglass Laura L. | Director | May 30, 2018 | Option Exercise | $6.00 | 500 | 3,000 | 500 | Jun 01, 2018, 09:12 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Mar 15, 2018 | Buy | $29.50 | 700,000 | 20,650,000 | 4,313,611 | Mar 26, 2018, 04:59 PM |
| TANG KEVIN C | Director | Mar 15, 2018 | Buy | $29.50 | 508,474 | 14,999,983 | 4,138,893 | Mar 19, 2018, 08:15 PM |
| TANG KEVIN C | Director | Mar 02, 2018 | Buy | $30.44 | 10,000 | 304,435 | 3,630,419 | Mar 02, 2018, 05:56 PM |
| TANG KEVIN C | Director | Feb 28, 2018 | Buy | $29.94 | 30,000 | 898,092 | 3,620,419 | Mar 02, 2018, 05:56 PM |
| CARVER JENNIFER | Chief Operating Officer | Feb 23, 2018 | Buy | $32.47 | 1,000 | 32,475 | 5,500 | Feb 27, 2018, 09:00 PM |
| TANG KEVIN C | Director | Feb 27, 2018 | Buy | $31.19 | 69,000 | 2,152,164 | 3,590,419 | Feb 27, 2018, 04:50 PM |
| TANG KEVIN C | Director | Feb 26, 2018 | Buy | $32.69 | 21,000 | 686,483 | 3,521,419 | Feb 27, 2018, 04:50 PM |
| TANG KEVIN C | Director | Feb 23, 2018 | Buy | $32.23 | 60,000 | 1,933,687 | 3,500,419 | Feb 27, 2018, 04:50 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Feb 15, 2018 | Buy | $32.42 | 50,000 | 1,621,000 | 3,613,611 | Feb 20, 2018, 04:19 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Feb 14, 2018 | Buy | $32.69 | 100,000 | 3,269,000 | 3,563,611 | Feb 15, 2018, 04:17 PM |
| PERCEPTIVE ADVISORS LLC | 10% Owner | Feb 13, 2018 | Buy | $32.75 | 75,000 | 2,456,250 | 3,463,611 | Feb 15, 2018, 04:17 PM |
| Douglass Laura L. | Director | Dec 29, 2017 | Option Exercise | $8.90 | 10,000 | 89,040 | 10,000 | Jan 03, 2018, 09:55 PM |
| Douglass Laura L. | Director | Dec 29, 2017 | Sale | $32.32 | 10,000 | 323,208 | 0 | Jan 03, 2018, 09:55 PM |
| CARVER JENNIFER | Chief Operating Officer | Dec 27, 2017 | Buy | $33.22 | 1,000 | 33,215 | 4,500 | Dec 29, 2017, 05:07 PM |
| TANG KEVIN C | Director | Mar 23, 2017 | Buy | $33.50 | 149,254 | 5,000,009 | 3,440,419 | Mar 27, 2017, 04:15 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 03, 2017 | Buy | $34.15 | 1,000 | 34,150 | 1,354,086 | Mar 06, 2017, 04:02 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 02, 2017 | Buy | $34.18 | 2,000 | 68,355 | 1,353,086 | Mar 06, 2017, 04:02 PM |
| CARVER JENNIFER | Chief Operating Officer | Mar 02, 2017 | Buy | $34.46 | 1,000 | 34,460 | 3,500 | Mar 06, 2017, 04:02 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 03, 2017 | Buy | $34.48 | 1,000 | 34,480 | 2,085 | Mar 06, 2017, 04:01 PM |
| Chawla Lakhmir S | Chief Medical Officer | Mar 02, 2017 | Buy | $35.33 | 600 | 21,198 | 1,085 | Mar 06, 2017, 04:01 PM |
| TANG KEVIN C | Director | Mar 02, 2017 | Buy | $34.64 | 100,000 | 3,463,840 | 3,291,165 | Mar 06, 2017, 04:01 PM |
| MULROY DENNIS | Chief Financial Officer | Mar 03, 2017 | Buy | $33.95 | 500 | 16,975 | 500 | Mar 06, 2017, 04:01 PM |
| TANG KEVIN C | Director | Sep 13, 2016 | Buy | $20.28 | 16,448 | 333,514 | 3,191,165 | Sep 13, 2016, 06:42 PM |
| TANG KEVIN C | Director | Sep 12, 2016 | Buy | $19.92 | 22,587 | 449,886 | 3,174,717 | Sep 13, 2016, 06:42 PM |
| TANG KEVIN C | Director | Sep 09, 2016 | Buy | $19.72 | 100,000 | 1,971,970 | 3,152,130 | Sep 13, 2016, 06:42 PM |
| TANG KEVIN C | Director | Mar 04, 2016 | Buy | $19.85 | 20,000 | 396,928 | 3,052,130 | Mar 08, 2016, 04:12 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Mar 01, 2016 | Buy | $16.57 | 2,000 | 33,140 | 1,425,086 | Mar 03, 2016, 06:22 PM |
| TANG KEVIN C | Director | Mar 02, 2016 | Buy | $18.19 | 30,528 | 555,439 | 2,958,630 | Mar 03, 2016, 04:22 PM |
| TANG KEVIN C | Director | Mar 01, 2016 | Buy | $16.38 | 55,972 | 916,814 | 2,928,102 | Mar 03, 2016, 04:22 PM |
| TANG KEVIN C | Director | Mar 03, 2016 | Buy | $18.77 | 73,500 | 1,379,234 | 3,032,130 | Mar 03, 2016, 04:22 PM |
| Chawla Lakhmir S | Chief Medical Officer | Sep 28, 2015 | Buy | $27.75 | 485 | 13,461 | 485 | Sep 30, 2015, 05:22 PM |
| TANG KEVIN C | Director | Sep 10, 2015 | Buy | $38.00 | 80,000 | 3,040,000 | 2,872,130 | Sep 14, 2015, 04:03 PM |
| TANG KEVIN C | Director | Aug 20, 2015 | Buy | $26.84 | 250,000 | 6,709,875 | 2,742,130 | Aug 21, 2015, 04:14 PM |
| TANG KEVIN C | Director | Aug 19, 2015 | Buy | $26.90 | 350,000 | 9,413,700 | 2,692,130 | Aug 21, 2015, 04:14 PM |
| TANG KEVIN C | Director | Aug 21, 2015 | Buy | $27.69 | 250,000 | 6,922,575 | 2,792,130 | Aug 21, 2015, 04:14 PM |
| TANG KEVIN C | Director | Jun 26, 2015 | Buy | $23.58 | 110,000 | 2,593,470 | 2,622,130 | Jun 30, 2015, 04:01 PM |
| TANG KEVIN C | Director | Jun 24, 2015 | Buy | $22.94 | 88,314 | 2,026,188 | 2,512,130 | Jun 24, 2015, 04:48 PM |
| TANG KEVIN C | Director | Jun 23, 2015 | Buy | $22.27 | 53,836 | 1,198,739 | 2,423,816 | Jun 24, 2015, 04:48 PM |
| TANG KEVIN C | Director | Jun 22, 2015 | Buy | $21.41 | 77,850 | 1,666,597 | 2,369,980 | Jun 24, 2015, 04:48 PM |
| Zarrabian Saiid | Director | May 14, 2015 | Buy | $19.50 | 307 | 5,987 | 688 | May 15, 2015, 04:44 PM |
| TANG KEVIN C | Director | May 13, 2015 | Buy | $18.63 | 47,483 | 884,532 | 2,292,130 | May 13, 2015, 05:02 PM |
| TANG KEVIN C | Director | May 12, 2015 | Buy | $18.25 | 44,400 | 810,362 | 2,244,647 | May 13, 2015, 05:02 PM |
| TANG KEVIN C | Director | May 11, 2015 | Buy | $18.04 | 98,700 | 1,780,548 | 2,200,247 | May 13, 2015, 05:02 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | May 12, 2015 | Buy | $18.36 | 2,000 | 36,720 | 1,423,086 | May 13, 2015, 04:55 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | May 12, 2015 | Buy | $18.38 | 2,000 | 36,760 | 22,000 | May 13, 2015, 04:55 PM |
| TANG KEVIN C | Director | Dec 16, 2014 | Buy | $13.95 | 582 | 8,117 | 2,101,547 | Dec 18, 2014, 04:21 PM |
| TANG KEVIN C | Director | Dec 15, 2014 | Buy | $13.93 | 32,343 | 450,574 | 2,100,965 | Dec 15, 2014, 08:23 PM |
| TANG KEVIN C | Director | Dec 12, 2014 | Buy | $13.71 | 77,304 | 1,059,846 | 2,068,622 | Dec 15, 2014, 08:23 PM |
| TANG KEVIN C | Director | Dec 11, 2014 | Buy | $12.01 | 122,696 | 1,473,910 | 1,991,318 | Dec 15, 2014, 08:23 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Dec 11, 2014 | Buy | $11.38 | 4,000 | 45,520 | 1,421,086 | Dec 12, 2014, 04:56 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Sep 26, 2014 | Buy | $9.35 | 2,000 | 18,700 | 1,417,086 | Sep 30, 2014, 06:40 PM |
| TANG KEVIN C | Director | Sep 25, 2014 | Buy | $9.17 | 30,500 | 279,688 | 1,824,567 | Sep 26, 2014, 07:18 PM |
| TANG KEVIN C | Director | Sep 24, 2014 | Buy | $9.10 | 95,000 | 864,443 | 1,794,067 | Sep 26, 2014, 07:18 PM |
| TANG KEVIN C | Director | Sep 26, 2014 | Buy | $9.21 | 44,055 | 405,861 | 1,868,622 | Sep 26, 2014, 07:18 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Sep 18, 2014 | Buy | $9.18 | 5,000 | 45,900 | 1,415,086 | Sep 22, 2014, 08:04 PM |
| Zarrabian Saiid | Director | Jul 31, 2014 | Buy | $9.53 | 381 | 3,631 | 381 | Aug 05, 2014, 05:31 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Jul 23, 2014 | Buy | $10.50 | 19,000 | 199,500 | 1,410,086 | Jul 25, 2014, 04:11 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | May 21, 2014 | Buy | $7.37 | 12,000 | 88,440 | 20,000 | May 22, 2014, 06:28 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Apr 11, 2014 | Buy | $9.76 | 4,000 | 39,040 | 2,000 | Apr 14, 2014, 07:47 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Apr 14, 2014 | Buy | $9.30 | 4,000 | 37,200 | 4,000 | Apr 14, 2014, 07:47 PM |
| TIDMARSH GEORGE F | President, CEO & Secretary | Feb 07, 2014 | Buy | $7.25 | 3,000 | 21,750 | 1,391,086 | Feb 11, 2014, 01:01 PM |
| TIDMARSH GEORGE F | President, CEO and Sec'y | Sep 24, 2013 | Option Exercise | $0.07 | 1,071,429 | 75,000 | 69,404,300 | Oct 25, 2013, 08:42 PM |
| Reinisch Richard | Individual Investor | Jul 25, 2012 | Buy | $0.09 | 121,200 | 10,908 | 500,000 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Jul 24, 2012 | Buy | $0.09 | 144,780 | 12,987 | 378,800 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Jul 23, 2012 | Buy | $0.08 | 234,000 | 18,018 | 234,020 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Mar 12, 2010 | Buy | $936.20 | 20 | 18,724 | 20 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Mar 19, 2013 | Buy | $0.09 | 100,000 | 9,176 | 1,100,000 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Aug 02, 2012 | Buy | $0.10 | 220,695 | 21,341 | 1,000,000 | Mar 22, 2013, 03:39 PM |
| Reinisch Richard | Individual Investor | Aug 01, 2012 | Buy | $0.10 | 279,305 | 26,590 | 779,305 | Mar 22, 2013, 03:39 PM |
| Gillespie Deirdre | President & CEO | May 09, 2011 | Option Exercise | $0.01 | 99,166 | 595 | 99,166 | May 18, 2011, 07:55 PM |
| Gillespie Deirdre | President & CEO | May 17, 2011 | Sale | $0.02 | 99,166 | 1,587 | 0 | May 18, 2011, 07:55 PM |
| SLOAN GAIL A | Chief Financial Officer | Jun 30, 2010 | Option Exercise | $3.91 | 140 | 547 | 1,080 | Apr 21, 2011, 08:13 PM |
| SLOAN GAIL A | Chief Financial Officer | Apr 20, 2011 | Sale | $1.00 | 100 | 100 | 980 | Apr 21, 2011, 08:13 PM |
| Gillespie Deirdre | President & CEO | Apr 19, 2011 | Sale | $0.70 | 4,376 | 3,063 | 0 | Apr 20, 2011, 05:13 PM |
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Option Exercise
| Owner | Relationship | Date | Value($) |
| RAMSAY DAVID A | Director | 08/22/2022 | 623,000 |
| TANG KEVIN C | Director | 08/22/2022 | 59,857,429 |
| Edwards Larry G. | Chief Executive Officer | 08/22/2022 | 74,567 |
| Johnson Laura L. | Director | 08/22/2022 | 3,115 |
| Johnson Craig A | Director | 08/22/2022 | 74,760 |
| Hearne Michael S | Chief Financial Officer | 08/22/2022 | 63,459 |
| Hearne Michael S | Chief Financial Officer | 08/22/2022 | 59,857,429 |
| TANG KEVIN C | Director | 08/22/2022 | 59,857,429 |
| Johnson Craig A | Director | 07/08/2022 | 47,160 |
| Hearne Michael S | Chief Financial Officer | 06/30/2022 | 640 |
| Hearne Michael S | Chief Financial Officer | 06/15/2022 | 642 |
| Hearne Michael S | Chief Financial Officer | 05/31/2022 | 644 |
| Hearne Michael S | Chief Financial Officer | 05/13/2022 | 641 |
| Hearne Michael S | Chief Financial Officer | 04/29/2022 | 642 |
| Edwards Larry G. | Chief Executive Officer | 04/14/2022 | 1,099 |
| Hearne Michael S | Chief Financial Officer | 04/14/2022 | 643 |
| Edwards Larry G. | Chief Executive Officer | 03/31/2022 | 1,212 |
| Hearne Michael S | Chief Financial Officer | 03/31/2022 | 642 |
| Edwards Larry G. | Chief Executive Officer | 03/15/2022 | 1,215 |
| Hearne Michael S | Chief Financial Officer | 03/15/2022 | 640 |
| Edwards Larry G. | Chief Executive Officer | 02/28/2022 | 1,217 |
| Hearne Michael S | Chief Financial Officer | 02/28/2022 | 643 |
| Edwards Larry G. | Chief Executive Officer | 02/15/2022 | 1,213 |
| Hearne Michael S | Chief Financial Officer | 02/15/2022 | 641 |
| Edwards Larry G. | Chief Executive Officer | 01/31/2022 | 16,411 |
| Hearne Michael S | Chief Financial Officer | 01/31/2022 | 6,592 |
| Edwards Larry G. | Chief Executive Officer | 01/14/2022 | 1,142 |
| Hearne Michael S | Chief Financial Officer | 01/14/2022 | 619 |
| Edwards Larry G. | Chief Executive Officer | 12/30/2021 | 913 |
| Edwards Larry G. | Chief Executive Officer | 12/15/2021 | 1,145 |
| Hearne Michael S | Chief Financial Officer | 12/15/2021 | 619 |
| RAMSAY DAVID A | Director | 12/06/2021 | 38,231 |
| RAMSAY DAVID A | Director | 12/03/2021 | 16,082 |
| RAMSAY DAVID A | Director | 12/02/2021 | 37,677 |
| Edwards Larry G. | Chief Executive Officer | 11/30/2021 | 1,147 |
| Hearne Michael S | Chief Financial Officer | 11/30/2021 | 617 |
| TANG KEVIN C | Director | 11/30/2021 | 277,612 |
| TANG KEVIN C | Director | 11/29/2021 | 793,107 |
| TANG KEVIN C | Director | 12/01/2021 | 663,431 |
| RAMSAY DAVID A | Director | 11/17/2021 | 31,725 |
| Edwards Larry G. | Chief Executive Officer | 11/15/2021 | 1,145 |
| Hearne Michael S | Chief Financial Officer | 11/15/2021 | 617 |
| Edwards Larry G. | Chief Executive Officer | 10/29/2021 | 1,145 |
| Hearne Michael S | Chief Financial Officer | 10/29/2021 | 618 |
| Edwards Larry G. | Chief Executive Officer | 10/15/2021 | 1,148 |
| Hearne Michael S | Chief Financial Officer | 10/15/2021 | 616 |
| Edwards Larry G. | Chief Executive Officer | 09/30/2021 | 1,146 |
| Hearne Michael S | Chief Financial Officer | 09/30/2021 | 617 |
| Edwards Larry G. | Chief Executive Officer | 09/15/2021 | 1,146 |
| Hearne Michael S | Chief Financial Officer | 09/15/2021 | 1,852 |
| Edwards Larry G. | Chief Executive Officer | 08/31/2021 | 1,145 |
| Edwards Larry G. | Chief Executive Officer | 08/13/2021 | 1,143 |
| Edwards Larry G. | Chief Executive Officer | 07/30/2021 | 1,148 |
| Hearne Michael S | Chief Financial Officer | 07/30/2021 | 617 |
| Hearne Michael S | Chief Financial Officer | 07/15/2021 | 617 |
| Edwards Larry G. | Chief Executive Officer | 07/15/2021 | 1,144 |
| Edwards Larry G. | Chief Executive Officer | 06/30/2021 | 1,146 |
| Hearne Michael S | Chief Financial Officer | 06/30/2021 | 618 |
| Edwards Larry G. | Chief Executive Officer | 05/28/2021 | 1,148 |
| Edwards Larry G. | Chief Executive Officer | 05/14/2021 | 1,144 |
| Hearne Michael S | Chief Financial Officer | 05/14/2021 | 617 |
| Edwards Larry G. | Chief Executive Officer | 04/15/2021 | 1,144 |
| Hearne Michael S | Chief Financial Officer | 04/15/2021 | 615 |
| Hearne Michael S | Chief Financial Officer | 03/15/2021 | 616 |
| Hearne Michael S | Chief Financial Officer | 02/26/2021 | 619 |
| Hearne Michael S | Chief Financial Officer | 02/12/2021 | 3,051 |
| Hearne Michael S | Chief Financial Officer | 01/29/2021 | 614 |
| Hearne Michael S | Chief Financial Officer | 01/15/2021 | 618 |
| Hearne Michael S | Chief Financial Officer | 12/31/2020 | 5,435 |
| Hearne Michael S | Chief Financial Officer | 01/15/2021 | 618 |
| Hearne Michael S | Chief Financial Officer | 12/31/2020 | 564 |
| Hearne Michael S | Chief Financial Officer | 12/15/2020 | 562 |
| Hearne Michael S | Chief Financial Officer | 11/30/2020 | 566 |
| Hearne Michael S | Chief Financial Officer | 11/13/2020 | 561 |
| Hearne Michael S | Chief Financial Officer | 10/30/2020 | 566 |
| Hearne Michael S | Chief Financial Officer | 10/15/2020 | 561 |
| Chawla Lakhmir S | Chief Medical Officer | 09/15/2020 | 1,101 |
| RAMSAY DAVID A | Director | 09/08/2020 | 3,830 |
| TANG KEVIN C | Director | 09/09/2020 | 509,940 |
| TANG KEVIN C | Director | 09/08/2020 | 328,529 |
| TANG KEVIN C | Director | 09/04/2020 | 258,359 |
| Chawla Lakhmir S | Chief Medical Officer | 08/31/2020 | 1,963 |
| RAMSAY DAVID A | Director | 08/24/2020 | 26,289 |
| RAMSAY DAVID A | Director | 08/21/2020 | 111,108 |
| RAMSAY DAVID A | Director | 08/20/2020 | 50,060 |
| Chawla Lakhmir S | Chief Medical Officer | 08/14/2020 | 1,967 |
| TANG KEVIN C | Director | 08/14/2020 | 653,694 |
| TANG KEVIN C | Director | 08/13/2020 | 800,586 |
| TANG KEVIN C | Director | 08/12/2020 | 150,820 |
| Chawla Lakhmir S | Chief Medical Officer | 07/31/2020 | 1,964 |
| Chawla Lakhmir S | Chief Medical Officer | 07/15/2020 | 1,964 |
| Chawla Lakhmir S | Chief Medical Officer | 06/30/2020 | 1,966 |
| Chawla Lakhmir S | Chief Medical Officer | 06/15/2020 | 1,962 |
| TANG KEVIN C | Director | 06/04/2020 | 1,065,636 |
| TANG KEVIN C | Director | 06/03/2020 | 714,783 |
| TANG KEVIN C | Director | 06/02/2020 | 1,237,060 |
| MULROY DENNIS | Chief Financial Officer | 05/29/2020 | 329 |
| Chawla Lakhmir S | Chief Medical Officer | 05/29/2020 | 1,969 |
| Rolke James | Chief Scientific Officer | 05/29/2020 | 822 |
| MULROY DENNIS | Chief Financial Officer | 05/15/2020 | 328 |
| Chawla Lakhmir S | Chief Medical Officer | 05/15/2020 | 1,963 |
| Rolke James | Chief Scientific Officer | 05/15/2020 | 820 |
| Rolke James | Chief Scientific Officer | 04/30/2020 | 821 |
| Chawla Lakhmir S | Chief Medical Officer | 04/30/2020 | 1,968 |
| MULROY DENNIS | Chief Financial Officer | 04/30/2020 | 327 |
| MULROY DENNIS | Chief Financial Officer | 04/15/2020 | 325 |
| Wellinghoff Darryl | Chief Commercial Officer | 04/15/2020 | 191 |
| Chawla Lakhmir S | Chief Medical Officer | 04/15/2020 | 1,964 |
| Rolke James | Chief Scientific Officer | 04/15/2020 | 819 |
| Chawla Lakhmir S | Chief Medical Officer | 03/31/2020 | 589 |
| Wellinghoff Darryl | Chief Commercial Officer | 03/31/2020 | 1,639 |
| Rolke James | Chief Scientific Officer | 03/31/2020 | 818 |
| Rolke James | Chief Scientific Officer | 03/13/2020 | 819 |
| Wellinghoff Darryl | Chief Commercial Officer | 03/13/2020 | 1,642 |
| Chawla Lakhmir S | Chief Medical Officer | 03/13/2020 | 588 |
| Rolke James | Chief Scientific Officer | 02/28/2020 | 821 |
| Chawla Lakhmir S | Chief Medical Officer | 02/28/2020 | 590 |
| Wellinghoff Darryl | Chief Commercial Officer | 02/28/2020 | 1,642 |
| Wellinghoff Darryl | Chief Commercial Officer | 02/14/2020 | 1,635 |
| Chawla Lakhmir S | Chief Medical Officer | 02/14/2020 | 593 |
| Rolke James | Chief Scientific Officer | 02/14/2020 | 821 |
| Chawla Lakhmir S | Chief Medical Officer | 01/31/2020 | 588 |
| Rolke James | Chief Scientific Officer | 01/31/2020 | 821 |
| Wellinghoff Darryl | Chief Commercial Officer | 01/31/2020 | 1,641 |
| TANG KEVIN C | Director | 02/03/2020 | 509,833 |
| TANG KEVIN C | Director | 01/31/2020 | 89,705 |
| TANG KEVIN C | Director | 01/30/2020 | 547,431 |
| Wellinghoff Darryl | Chief Commercial Officer | 01/15/2020 | 7,960 |
| Chawla Lakhmir S | Chief Medical Officer | 01/15/2020 | 3,337 |
| Rolke James | Chief Scientific Officer | 01/15/2020 | 4,636 |
| Wellinghoff Darryl | Chief Commercial Officer | 01/14/2020 | 24,677 |
| TANG KEVIN C | Director | 01/13/2020 | 8,351,580 |
| TANG KEVIN C | Director | 01/10/2020 | 4,090,909 |
| TANG KEVIN C | Director | 01/09/2020 | 4,991,980 |
| Chawla Lakhmir S | Chief Medical Officer | 12/31/2019 | 574 |
| MULROY DENNIS | Chief Financial Officer | 12/31/2019 | 53 |
| MULROY DENNIS | Chief Financial Officer | 12/13/2019 | 319 |
| Chawla Lakhmir S | Chief Medical Officer | 12/13/2019 | 573 |
| Chawla Lakhmir S | Chief Medical Officer | 11/29/2019 | 576 |
| MULROY DENNIS | Chief Financial Officer | 11/29/2019 | 322 |
| Wellinghoff Darryl | Chief Commercial Officer | 11/29/2019 | 40 |
| Rolke James | Chief Scientific Officer | 11/15/2019 | 604 |
| Wellinghoff Darryl | Chief Commercial Officer | 11/15/2019 | 1,592 |
| MULROY DENNIS | Chief Financial Officer | 11/15/2019 | 317 |
| Chawla Lakhmir S | Chief Medical Officer | 11/15/2019 | 568 |
| Rolke James | Chief Scientific Officer | 10/31/2019 | 793 |
| Wellinghoff Darryl | Chief Commercial Officer | 10/31/2019 | 1,591 |
| Chawla Lakhmir S | Chief Medical Officer | 10/31/2019 | 572 |
| MULROY DENNIS | Chief Financial Officer | 10/31/2019 | 1,591 |
| Wellinghoff Darryl | Chief Commercial Officer | 10/15/2019 | 1,595 |
| Chawla Lakhmir S | Chief Medical Officer | 10/15/2019 | 577 |
| MULROY DENNIS | Chief Financial Officer | 10/15/2019 | 1,595 |
| Rolke James | Chief Scientific Officer | 10/15/2019 | 797 |
| Rolke James | Chief Scientific Officer | 09/30/2019 | 800 |
| MULROY DENNIS | Chief Financial Officer | 09/30/2019 | 1,593 |
| Chawla Lakhmir S | Chief Medical Officer | 09/30/2019 | 568 |
| Wellinghoff Darryl | Chief Commercial Officer | 09/30/2019 | 1,593 |
| Rolke James | Chief Scientific Officer | 09/13/2019 | 789 |
| MULROY DENNIS | Chief Financial Officer | 09/13/2019 | 1,587 |
| Wellinghoff Darryl | Chief Commercial Officer | 09/13/2019 | 1,587 |
| Chawla Lakhmir S | Chief Medical Officer | 09/13/2019 | 575 |
| MULROY DENNIS | Chief Financial Officer | 08/30/2019 | 1,593 |
| Wellinghoff Darryl | Chief Commercial Officer | 08/30/2019 | 1,593 |
| Chawla Lakhmir S | Chief Medical Officer | 08/30/2019 | 569 |
| Rolke James | Chief Scientific Officer | 08/30/2019 | 797 |
| Rolke James | Chief Scientific Officer | 08/15/2019 | 794 |
| Chawla Lakhmir S | Chief Medical Officer | 08/15/2019 | 577 |
| MULROY DENNIS | Chief Financial Officer | 08/15/2019 | 1,588 |
| Wellinghoff Darryl | Chief Commercial Officer | 08/15/2019 | 1,588 |
| MULROY DENNIS | Chief Financial Officer | 07/31/2019 | 1,593 |
| Chawla Lakhmir S | Chief Medical Officer | 07/31/2019 | 569 |
| Wellinghoff Darryl | Chief Commercial Officer | 07/31/2019 | 1,593 |
| Rolke James | Chief Scientific Officer | 07/31/2019 | 796 |
| MULROY DENNIS | Chief Financial Officer | 07/15/2019 | 1,594 |
| Wellinghoff Darryl | Chief Commercial Officer | 07/15/2019 | 1,594 |
| Rolke James | Chief Scientific Officer | 07/15/2019 | 801 |
| Chawla Lakhmir S | Chief Medical Officer | 07/15/2019 | 573 |
| MULROY DENNIS | Chief Financial Officer | 06/28/2019 | 1,588 |
| Rolke James | Chief Scientific Officer | 06/28/2019 | 794 |
| Wellinghoff Darryl | Chief Commercial Officer | 06/28/2019 | 1,588 |
| Chawla Lakhmir S | Chief Medical Officer | 06/28/2019 | 574 |
| Wellinghoff Darryl | Chief Commercial Officer | 06/14/2019 | 1,592 |
| MULROY DENNIS | Chief Financial Officer | 06/14/2019 | 1,592 |
| Rolke James | Chief Scientific Officer | 06/14/2019 | 792 |
| Chawla Lakhmir S | Chief Medical Officer | 06/14/2019 | 569 |
| Chawla Lakhmir S | Chief Medical Officer | 05/31/2019 | 577 |
| Rolke James | Chief Scientific Officer | 05/31/2019 | 797 |
| Wellinghoff Darryl | Chief Commercial Officer | 05/31/2019 | 1,589 |
| MULROY DENNIS | Chief Financial Officer | 05/31/2019 | 1,589 |
| Rolke James | Chief Scientific Officer | 05/15/2019 | 798 |
| Wellinghoff Darryl | Chief Commercial Officer | 05/15/2019 | 1,590 |
| Chawla Lakhmir S | Chief Medical Officer | 05/15/2019 | 569 |
| MULROY DENNIS | Chief Financial Officer | 05/15/2019 | 1,590 |
| MULROY DENNIS | Chief Financial Officer | 04/30/2019 | 1,594 |
| Rolke James | Chief Scientific Officer | 04/30/2019 | 793 |
| Chawla Lakhmir S | Chief Medical Officer | 04/30/2019 | 575 |
| Wellinghoff Darryl | Chief Commercial Officer | 04/30/2019 | 1,594 |
| Chawla Lakhmir S | Chief Medical Officer | 04/15/2019 | 572 |
| Wellinghoff Darryl | Chief Commercial Officer | 04/15/2019 | 1,589 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 04/15/2019 | 12 |
| MULROY DENNIS | Chief Financial Officer | 04/15/2019 | 1,589 |
| Rolke James | Chief Scientific Officer | 04/15/2019 | 798 |
| Rolke James | Chief Scientific Officer | 03/29/2019 | 799 |
| MULROY DENNIS | Chief Financial Officer | 03/29/2019 | 323 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/29/2019 | 514 |
| Chawla Lakhmir S | Chief Medical Officer | 03/29/2019 | 191 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/15/2019 | 1,266 |
| Rolke James | Chief Scientific Officer | 03/15/2019 | 792 |
| Chawla Lakhmir S | Chief Medical Officer | 03/15/2019 | 188 |
| MULROY DENNIS | Chief Financial Officer | 03/15/2019 | 318 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 02/28/2019 | 1,266 |
| Rolke James | Chief Scientific Officer | 02/28/2019 | 795 |
| MULROY DENNIS | Chief Financial Officer | 02/28/2019 | 315 |
| Chawla Lakhmir S | Chief Medical Officer | 02/28/2019 | 194 |
| CARVER JENNIFER | Chief Operating Officer | 02/28/2019 | 1,115 |
| Chawla Lakhmir S | Chief Medical Officer | 02/15/2019 | 191 |
| MULROY DENNIS | Chief Financial Officer | 02/15/2019 | 318 |
| CARVER JENNIFER | Chief Operating Officer | 02/15/2019 | 1,219 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 02/15/2019 | 1,267 |
| Rolke James | Chief Scientific Officer | 02/15/2019 | 800 |
| CARVER JENNIFER | Chief Operating Officer | 01/31/2019 | 6,464 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 01/31/2019 | 1,262 |
| MULROY DENNIS | Chief Financial Officer | 01/31/2019 | 323 |
| Rolke James | Chief Scientific Officer | 01/31/2019 | 795 |
| Chawla Lakhmir S | Chief Medical Officer | 01/31/2019 | 190 |
| Chawla Lakhmir S | Chief Medical Officer | 01/30/2019 | 5,570 |
| Chawla Lakhmir S | Chief Medical Officer | 01/29/2019 | 11,124 |
| CARVER JENNIFER | Chief Operating Officer | 01/15/2019 | 1,223 |
| MULROY DENNIS | Chief Financial Officer | 01/15/2019 | 1,814 |
| Chawla Lakhmir S | Chief Medical Officer | 01/15/2019 | 413 |
| Rolke James | Chief Scientific Officer | 01/15/2019 | 4,546 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 01/15/2019 | 5,017 |
| TANG KEVIN C | Director | 01/09/2019 | 438,806 |
| TANG KEVIN C | Director | 01/08/2019 | 5,962,639 |
| TANG KEVIN C | Director | 01/07/2019 | 583,840 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 01/07/2019 | 11,700 |
| CARVER JENNIFER | Chief Operating Officer | 01/09/2019 | 30,825 |
| Rolke James | Chief Scientific Officer | 01/09/2019 | 9,746 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 01/08/2019 | 6,568,236 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 01/07/2019 | 5,147,749 |
| Chawla Lakhmir S | Chief Medical Officer | 12/31/2018 | 184 |
| Rolke James | Chief Scientific Officer | 12/31/2018 | 778 |
| MULROY DENNIS | Chief Financial Officer | 12/31/2018 | 313 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 12/31/2018 | 1,234 |
| CARVER JENNIFER | Chief Operating Officer | 12/31/2018 | 1,186 |
| Chawla Lakhmir S | Chief Medical Officer | 12/14/2018 | 185 |
| MULROY DENNIS | Chief Financial Officer | 12/14/2018 | 305 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 12/14/2018 | 1,219 |
| Rolke James | Chief Scientific Officer | 12/14/2018 | 762 |
| CARVER JENNIFER | Chief Operating Officer | 12/14/2018 | 1,175 |
| MULROY DENNIS | Chief Financial Officer | 11/30/2018 | 320 |
| Rolke James | Chief Scientific Officer | 11/30/2018 | 775 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 11/30/2018 | 1,230 |
| Chawla Lakhmir S | Chief Medical Officer | 11/30/2018 | 197 |
| CARVER JENNIFER | Chief Operating Officer | 11/30/2018 | 1,181 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 11/15/2018 | 1,229 |
| Rolke James | Chief Scientific Officer | 11/15/2018 | 773 |
| MULROY DENNIS | Chief Financial Officer | 11/15/2018 | 304 |
| CARVER JENNIFER | Chief Operating Officer | 11/15/2018 | 1,191 |
| Chawla Lakhmir S | Chief Medical Officer | 11/15/2018 | 203 |
| Rolke James | Chief Scientific Officer | 10/31/2018 | 776 |
| CARVER JENNIFER | Chief Operating Officer | 10/31/2018 | 1,178 |
| Chawla Lakhmir S | Chief Medical Officer | 10/31/2018 | 208 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 10/31/2018 | 1,233 |
| MULROY DENNIS | Chief Financial Officer | 10/31/2018 | 305 |
| MULROY DENNIS | Chief Financial Officer | 10/15/2018 | 304 |
| Chawla Lakhmir S | Chief Medical Officer | 10/15/2018 | 207 |
| Rolke James | Chief Scientific Officer | 10/15/2018 | 760 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 10/15/2018 | 1,215 |
| CARVER JENNIFER | Chief Operating Officer | 10/15/2018 | 1,174 |
| Rolke James | Chief Scientific Officer | 08/16/2018 | 21,997 |
| CARVER JENNIFER | Chief Operating Officer | 08/16/2018 | 20,895 |
| Douglass Laura L. | Director | 05/30/2018 | 3,000 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 03/15/2018 | 20,650,000 |
| TANG KEVIN C | Director | 03/15/2018 | 14,999,983 |
| TANG KEVIN C | Director | 03/02/2018 | 304,435 |
| TANG KEVIN C | Director | 02/28/2018 | 898,092 |
| CARVER JENNIFER | Chief Operating Officer | 02/23/2018 | 32,475 |
| TANG KEVIN C | Director | 02/27/2018 | 2,152,164 |
| TANG KEVIN C | Director | 02/26/2018 | 686,483 |
| TANG KEVIN C | Director | 02/23/2018 | 1,933,687 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 02/15/2018 | 1,621,000 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 02/14/2018 | 3,269,000 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 02/13/2018 | 2,456,250 |
| Douglass Laura L. | Director | 12/29/2017 | 89,040 |
| Douglass Laura L. | Director | 12/29/2017 | 323,208 |
| CARVER JENNIFER | Chief Operating Officer | 12/27/2017 | 33,215 |
| TANG KEVIN C | Director | 03/23/2017 | 5,000,009 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/03/2017 | 34,150 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/02/2017 | 68,355 |
| CARVER JENNIFER | Chief Operating Officer | 03/02/2017 | 34,460 |
| Chawla Lakhmir S | Chief Medical Officer | 03/03/2017 | 34,480 |
| Chawla Lakhmir S | Chief Medical Officer | 03/02/2017 | 21,198 |
| TANG KEVIN C | Director | 03/02/2017 | 3,463,840 |
| MULROY DENNIS | Chief Financial Officer | 03/03/2017 | 16,975 |
| TANG KEVIN C | Director | 09/13/2016 | 333,514 |
| TANG KEVIN C | Director | 09/12/2016 | 449,886 |
| TANG KEVIN C | Director | 09/09/2016 | 1,971,970 |
| TANG KEVIN C | Director | 03/04/2016 | 396,928 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 03/01/2016 | 33,140 |
| TANG KEVIN C | Director | 03/02/2016 | 555,439 |
| TANG KEVIN C | Director | 03/01/2016 | 916,814 |
| TANG KEVIN C | Director | 03/03/2016 | 1,379,234 |
| Chawla Lakhmir S | Chief Medical Officer | 09/28/2015 | 13,461 |
| TANG KEVIN C | Director | 09/10/2015 | 3,040,000 |
| TANG KEVIN C | Director | 08/20/2015 | 6,709,875 |
| TANG KEVIN C | Director | 08/19/2015 | 9,413,700 |
| TANG KEVIN C | Director | 08/21/2015 | 6,922,575 |
| TANG KEVIN C | Director | 06/26/2015 | 2,593,470 |
| TANG KEVIN C | Director | 06/24/2015 | 2,026,188 |
| TANG KEVIN C | Director | 06/23/2015 | 1,198,739 |
| TANG KEVIN C | Director | 06/22/2015 | 1,666,597 |
| Zarrabian Saiid | Director | 05/14/2015 | 5,987 |
| TANG KEVIN C | Director | 05/13/2015 | 884,532 |
| TANG KEVIN C | Director | 05/12/2015 | 810,362 |
| TANG KEVIN C | Director | 05/11/2015 | 1,780,548 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 05/12/2015 | 36,720 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 05/12/2015 | 36,760 |
| TANG KEVIN C | Director | 12/16/2014 | 8,117 |
| TANG KEVIN C | Director | 12/15/2014 | 450,574 |
| TANG KEVIN C | Director | 12/12/2014 | 1,059,846 |
| TANG KEVIN C | Director | 12/11/2014 | 1,473,910 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 12/11/2014 | 45,520 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 09/26/2014 | 18,700 |
| TANG KEVIN C | Director | 09/25/2014 | 279,688 |
| TANG KEVIN C | Director | 09/24/2014 | 864,443 |
| TANG KEVIN C | Director | 09/26/2014 | 405,861 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 09/18/2014 | 45,900 |
| Zarrabian Saiid | Director | 07/31/2014 | 3,631 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 07/23/2014 | 199,500 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 05/21/2014 | 88,440 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 04/11/2014 | 39,040 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 04/14/2014 | 37,200 |
| TIDMARSH GEORGE F | President, CEO & Secretary | 02/07/2014 | 21,750 |
| TIDMARSH GEORGE F | President, CEO and Sec'y | 09/24/2013 | 75,000 |
| Reinisch Richard | Individual Investor | 07/25/2012 | 10,908 |
| Reinisch Richard | Individual Investor | 07/24/2012 | 12,987 |
| Reinisch Richard | Individual Investor | 07/23/2012 | 18,018 |
| Reinisch Richard | Individual Investor | 03/12/2010 | 18,724 |
| Reinisch Richard | Individual Investor | 03/19/2013 | 9,176 |
| Reinisch Richard | Individual Investor | 08/02/2012 | 21,341 |
| Reinisch Richard | Individual Investor | 08/01/2012 | 26,590 |
| Gillespie Deirdre | President & CEO | 05/09/2011 | 595 |
| Gillespie Deirdre | President & CEO | 05/17/2011 | 1,587 |
| SLOAN GAIL A | Chief Financial Officer | 06/30/2010 | 547 |
| SLOAN GAIL A | Chief Financial Officer | 04/20/2011 | 100 |
| Gillespie Deirdre | President & CEO | 04/19/2011 | 3,063 |
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