. (FMI)
$137 - (-)
Market Cap: -
As of 12/31/18 12:00 AM EST. Market closed.
. (FMI)
$137
- (-)
Market Cap: -
As of 12/31/18 12:00 AM EST. Market closed.
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COMPANY PROFILE
Sector
Industry
CEO Compensation (Base)
$486,539
CEO Compensation (Total)
$6.18M
URL
Address
.
Sector
Industry
CEO Compensation (Base)
$486,539
CEO Compensation (Total)
$6.18M
URL
Address
.
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INSIDEARBITRAGE ARTICLES
KEY STATS
Open
-
Previous Close
$137
Days Range
- - -
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
0
Open
-
Previous Close
$137
Days Range
- - -
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
0
FINANCIAL STATEMENTS FOR
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| ROCHE HOLDINGS INC | Director | Jul 31, 2018 | Buy | $137.00 | 16,221,027 | 2,222,280,699 | 36,825,315 | Aug 02, 2018, 07:08 PM |
| Yeshwant Krishna | Director | Jul 31, 2018 | Option Exercise | $137.00 | 5,786 | 792,682 | 0 | Aug 02, 2018, 04:10 PM |
| Ryan Jason | Chief Financial Officer | Jul 31, 2018 | Option Exercise | $137.00 | 42,215 | 5,783,455 | 0 | Aug 02, 2018, 04:09 PM |
| Ryan Jason | Chief Financial Officer | Jul 31, 2018 | Option Exercise | $137.00 | 6,955 | 952,835 | 42,215 | Aug 02, 2018, 04:09 PM |
| Pellini Michael J | Director | Jul 31, 2018 | Option Exercise | $137.00 | 103,711 | 14,208,407 | 0 | Aug 02, 2018, 04:09 PM |
| Nallicheri Melanie | Chief Business Officer | Jul 31, 2018 | Option Exercise | $137.00 | 46,937 | 6,430,369 | 0 | Aug 02, 2018, 04:08 PM |
| Nallicheri Melanie | Chief Business Officer | Jul 31, 2018 | Option Exercise | $137.00 | 19,074 | 2,613,138 | 46,937 | Aug 02, 2018, 04:08 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 31, 2018 | Option Exercise | $137.00 | 36,186 | 4,957,482 | 0 | Aug 02, 2018, 04:07 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 31, 2018 | Option Exercise | $137.00 | 30,993 | 4,246,041 | 36,186 | Aug 02, 2018, 04:07 PM |
| JONES EVAN/ FA | Director | Jul 31, 2018 | Option Exercise | $137.00 | 9,300 | 1,274,100 | 0 | Aug 02, 2018, 04:07 PM |
| JONES EVAN/ FA | Director | Jul 31, 2018 | Option Exercise | $137.00 | 17,652 | 2,418,324 | 0 | Aug 02, 2018, 04:07 PM |
| Hesslein Robert W. | SVP and General Counsel | Jul 31, 2018 | Option Exercise | $137.00 | 28,709 | 3,933,133 | 0 | Aug 02, 2018, 04:06 PM |
| Hesslein Robert W. | SVP and General Counsel | Jul 31, 2018 | Option Exercise | $137.00 | 76,494 | 10,479,678 | 28,709 | Aug 02, 2018, 04:06 PM |
| Fiedler Konstantin | Chief Operating Officer | Jul 31, 2018 | Option Exercise | $137.00 | 23,582 | 3,230,734 | 0 | Aug 02, 2018, 04:05 PM |
| Fiedler Konstantin | Chief Operating Officer | Jul 31, 2018 | Option Exercise | $137.00 | 3,253 | 445,661 | 23,582 | Aug 02, 2018, 04:05 PM |
| DOUGHERTY MICHAEL R | Director | Jul 31, 2018 | Option Exercise | $137.00 | 12,669 | 1,735,653 | 0 | Aug 02, 2018, 04:05 PM |
| DOUGHERTY MICHAEL R | Director | Jul 31, 2018 | Option Exercise | $137.00 | 12,120 | 1,660,440 | 12,669 | Aug 02, 2018, 04:05 PM |
| Doherty Michael J | Head of Product Development | Jul 31, 2018 | Option Exercise | $137.00 | 65,332 | 8,950,484 | 0 | Aug 02, 2018, 04:04 PM |
| Doherty Michael J | Head of Product Development | Jul 31, 2018 | Option Exercise | $137.00 | 15,955 | 2,185,835 | 65,332 | Aug 02, 2018, 04:04 PM |
| Cox Troy | President and CEO | Jul 31, 2018 | Option Exercise | $137.00 | 206,847 | 28,338,039 | 0 | Aug 02, 2018, 04:04 PM |
| Cox Troy | President and CEO | Jul 31, 2018 | Option Exercise | $137.00 | 35,221 | 4,825,277 | 206,847 | Aug 02, 2018, 04:04 PM |
| Civik Thomas | Chief Commercial Officer | Jul 31, 2018 | Option Exercise | $137.00 | 33,421 | 4,578,677 | 0 | Aug 02, 2018, 04:03 PM |
| Borisy Alexis | Director | Jul 31, 2018 | Option Exercise | $137.00 | 73,173 | 10,024,701 | 0 | Aug 02, 2018, 04:03 PM |
| Ryan Jason | Chief Financial Officer | Jul 02, 2018 | Sale | $136.66 | 3,403 | 465,054 | 49,170 | Jul 05, 2018, 04:10 PM |
| Nallicheri Melanie | Chief Business Officer | Jul 02, 2018 | Sale | $136.66 | 2,008 | 274,413 | 66,011 | Jul 05, 2018, 04:09 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 02, 2018 | Sale | $136.66 | 2,909 | 397,544 | 67,179 | Jul 05, 2018, 04:09 PM |
| Hesslein Robert W. | SVP and General Counsel | Jul 02, 2018 | Sale | $136.66 | 2,520 | 344,383 | 105,203 | Jul 05, 2018, 04:08 PM |
| Fiedler Konstantin | Chief Operating Officer | Jul 02, 2018 | Sale | $136.66 | 994 | 135,840 | 26,835 | Jul 05, 2018, 04:08 PM |
| Doherty Michael J | Head of Product Development | Jul 02, 2018 | Sale | $136.66 | 2,675 | 365,566 | 81,287 | Jul 05, 2018, 04:07 PM |
| Cox Troy | Chief Executive Officer | Jul 02, 2018 | Sale | $136.66 | 1,402 | 191,597 | 242,068 | Jul 05, 2018, 04:06 PM |
| Pellini Michael J | Director | Jun 15, 2018 | Sale | $105.45 | 3,500 | 369,075 | 103,711 | Jun 19, 2018, 04:03 PM |
| Miller Vincent A. | Chief Medical Officer | May 21, 2018 | Option Exercise | $29.94 | 1,570 | 47,006 | 71,658 | May 23, 2018, 04:06 PM |
| Miller Vincent A. | Chief Medical Officer | May 21, 2018 | Sale | $85.00 | 1,570 | 133,450 | 70,088 | May 23, 2018, 04:06 PM |
| Cox Troy | Chief Executive Officer | May 16, 2018 | Sale | $77.10 | 2,157 | 166,305 | 243,470 | May 17, 2018, 04:13 PM |
| Pellini Michael J | Director | May 15, 2018 | Sale | $76.05 | 3,500 | 266,175 | 107,211 | May 17, 2018, 04:12 PM |
| Cox Troy | Chief Executive Officer | May 07, 2018 | Sale | $70.01 | 7,063 | 494,481 | 245,627 | May 09, 2018, 04:04 PM |
| Ryan Jason | Chief Financial Officer | Apr 16, 2018 | Sale | $74.30 | 3,449 | 256,261 | 52,573 | Apr 18, 2018, 04:08 PM |
| Pellini Michael J | Director | Apr 16, 2018 | Sale | $74.65 | 3,500 | 261,275 | 110,711 | Apr 18, 2018, 04:08 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 16, 2018 | Sale | $74.02 | 3,283 | 243,008 | 70,088 | Apr 18, 2018, 04:07 PM |
| Ryan Jason | Chief Financial Officer | Apr 03, 2018 | Sale | $72.40 | 1 | 72 | 56,022 | Apr 05, 2018, 04:15 PM |
| Doherty Michael J | Head of Product Development | Apr 03, 2018 | Sale | $72.40 | 2 | 145 | 83,962 | Apr 05, 2018, 04:15 PM |
| Pellini Michael J | Director | Apr 03, 2018 | Sale | $70.28 | 13,659 | 959,955 | 114,211 | Apr 05, 2018, 04:14 PM |
| Ryan Jason | Chief Financial Officer | Apr 01, 2018 | Option Exercise | $78.75 | 12,932 | 1,018,395 | 62,162 | Apr 03, 2018, 04:13 PM |
| Ryan Jason | Chief Financial Officer | Apr 02, 2018 | Sale | $76.23 | 6,139 | 467,959 | 59,053 | Apr 03, 2018, 04:13 PM |
| Nallicheri Melanie | Chief Business Officer | Apr 01, 2018 | Option Exercise | $78.75 | 11,495 | 905,231 | 69,272 | Apr 03, 2018, 04:13 PM |
| Nallicheri Melanie | Chief Business Officer | Apr 02, 2018 | Sale | $74.88 | 1,253 | 93,825 | 68,019 | Apr 03, 2018, 04:13 PM |
| Miller Vincent A. | Chief Medical Officer | Mar 09, 2018 | Option Exercise | $29.94 | 6,811 | 203,921 | 80,133 | Apr 03, 2018, 04:12 PM |
| Miller Vincent A. | Chief Medical Officer | Mar 09, 2018 | Sale | $85.00 | 16,811 | 1,428,935 | 73,322 | Apr 03, 2018, 04:12 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 01, 2018 | Option Exercise | $78.75 | 12,932 | 1,018,395 | 76,254 | Apr 03, 2018, 04:11 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 02, 2018 | Sale | $74.88 | 2,883 | 215,871 | 75,900 | Apr 03, 2018, 04:11 PM |
| Fiedler Konstantin | Chief Operating Officer | Apr 01, 2018 | Option Exercise | $78.75 | 17,344 | 1,365,840 | 28,187 | Apr 03, 2018, 04:10 PM |
| Fiedler Konstantin | Chief Operating Officer | Apr 02, 2018 | Sale | $74.88 | 358 | 26,807 | 27,829 | Apr 03, 2018, 04:10 PM |
| Doherty Michael J | Head of Product Development | Apr 01, 2018 | Option Exercise | $78.75 | 8,621 | 678,904 | 92,154 | Apr 03, 2018, 04:09 PM |
| Doherty Michael J | Head of Product Development | Apr 02, 2018 | Sale | $74.87 | 8,190 | 613,185 | 83,964 | Apr 03, 2018, 04:09 PM |
| Cox Troy | Chief Executive Officer | Apr 01, 2018 | Option Exercise | $78.75 | 37,357 | 2,941,864 | 252,690 | Apr 03, 2018, 04:09 PM |
| Hesslein Robert W. | SVP and General Counsel | Apr 01, 2018 | Option Exercise | $78.75 | 8,621 | 678,904 | 106,964 | Apr 03, 2018, 12:00 AM |
| Hesslein Robert W. | SVP and General Counsel | Apr 02, 2018 | Option Exercise | $7.12 | 2,344 | 16,689 | 109,308 | Apr 03, 2018, 12:00 AM |
| Hesslein Robert W. | SVP and General Counsel | Apr 02, 2018 | Sale | $74.88 | 1,585 | 118,685 | 107,723 | Apr 03, 2018, 12:00 AM |
| Pellini Michael J | Director | Mar 15, 2018 | Sale | $78.29 | 3,500 | 274,015 | 127,870 | Mar 19, 2018, 04:18 PM |
| Ryan Jason | Chief Financial Officer | Mar 15, 2018 | Option Exercise | $29.63 | 15,000 | 444,450 | 57,083 | Mar 19, 2018, 04:17 PM |
| Ryan Jason | Chief Financial Officer | Mar 15, 2018 | Sale | $78.26 | 15,000 | 1,173,900 | 49,230 | Mar 19, 2018, 04:17 PM |
| Miller Vincent A. | Chief Medical Officer | Feb 20, 2018 | Option Exercise | $29.94 | 6,811 | 203,921 | 80,133 | Mar 12, 2018, 04:15 PM |
| Miller Vincent A. | Chief Medical Officer | Feb 20, 2018 | Sale | $85.00 | 16,811 | 1,428,935 | 73,322 | Mar 12, 2018, 04:15 PM |
| Miller Vincent A. | Chief Medical Officer | Feb 20, 2018 | Option Exercise | $6.47 | 12,008 | 77,703 | 102,697 | Feb 22, 2018, 04:03 PM |
| Miller Vincent A. | Chief Medical Officer | Feb 20, 2018 | Sale | $76.87 | 32,008 | 2,460,455 | 93,322 | Feb 22, 2018, 04:03 PM |
| Ryan Jason | Chief Financial Officer | Feb 15, 2018 | Option Exercise | $29.63 | 15,000 | 444,450 | 64,230 | Feb 20, 2018, 04:05 PM |
| Ryan Jason | Chief Financial Officer | Feb 15, 2018 | Sale | $67.53 | 15,000 | 1,012,950 | 49,230 | Feb 20, 2018, 04:05 PM |
| Pellini Michael J | Director | Feb 15, 2018 | Sale | $67.69 | 17,324 | 1,172,662 | 131,370 | Feb 20, 2018, 04:04 PM |
| Cox Troy | Chief Executive Officer | Feb 15, 2018 | Sale | $67.22 | 9,012 | 605,787 | 215,333 | Feb 20, 2018, 04:04 PM |
| Kafka Steven J. | President & COO | Feb 13, 2018 | Sale | $61.55 | 29,791 | 1,833,636 | 31,570 | Feb 15, 2018, 04:06 PM |
| Kafka Steven J. | President & COO | Feb 07, 2018 | Sale | $70.13 | 23,064 | 1,617,478 | 61,361 | Feb 09, 2018, 04:04 PM |
| Cox Troy | Chief Executive Officer | Feb 07, 2018 | Sale | $70.13 | 26,713 | 1,873,383 | 224,345 | Feb 09, 2018, 04:03 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 29, 2018 | Option Exercise | $4.16 | 4,400 | 18,304 | 97,722 | Jan 31, 2018, 04:03 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 29, 2018 | Sale | $75.00 | 4,400 | 330,000 | 93,322 | Jan 31, 2018, 04:03 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 22, 2018 | Option Exercise | $0.84 | 17,187 | 14,437 | 110,509 | Jan 24, 2018, 04:19 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 22, 2018 | Sale | $70.27 | 17,187 | 1,207,730 | 93,322 | Jan 24, 2018, 04:19 PM |
| Ryan Jason | Chief Financial Officer | Jan 16, 2018 | Option Exercise | $29.63 | 20,000 | 592,600 | 69,230 | Jan 18, 2018, 04:05 PM |
| Ryan Jason | Chief Financial Officer | Jan 16, 2018 | Sale | $64.38 | 21,035 | 1,354,233 | 49,230 | Jan 18, 2018, 04:05 PM |
| Pellini Michael J | Director | Jan 17, 2018 | Sale | $65.52 | 10,150 | 665,028 | 148,694 | Jan 18, 2018, 04:04 PM |
| Pellini Michael J | Director | Jan 16, 2018 | Sale | $64.19 | 27,138 | 1,741,988 | 158,844 | Jan 18, 2018, 04:04 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 17, 2018 | Option Exercise | $0.84 | 5,534 | 4,649 | 98,856 | Jan 18, 2018, 04:04 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 16, 2018 | Option Exercise | $0.84 | 5,408 | 4,543 | 98,730 | Jan 18, 2018, 04:04 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 16, 2018 | Sale | $65.26 | 9,221 | 601,762 | 93,322 | Jan 18, 2018, 04:04 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 17, 2018 | Sale | $65.39 | 5,534 | 361,868 | 93,322 | Jan 18, 2018, 04:04 PM |
| Kafka Steven J. | President & COO | Jan 16, 2018 | Sale | $65.71 | 4,148 | 272,565 | 84,425 | Jan 18, 2018, 04:03 PM |
| Hesslein Robert W. | SVP and General Counsel | Jan 16, 2018 | Sale | $64.30 | 18,021 | 1,158,750 | 98,343 | Jan 18, 2018, 04:03 PM |
| Nallicheri Melanie | Chief Business Officer | Jan 02, 2018 | Sale | $64.00 | 1,494 | 95,616 | 57,777 | Jan 03, 2018, 05:19 PM |
| Miller Vincent A. | Chief Medical Officer | Dec 07, 2017 | Option Exercise | $62.25 | 500 | 31,125 | 99,484 | Jan 03, 2018, 05:18 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 02, 2018 | Sale | $64.00 | 2,349 | 150,336 | 99,092 | Jan 03, 2018, 05:18 PM |
| Kafka Steven J. | President & COO | Jan 03, 2018 | Sale | $64.00 | 2,257 | 144,448 | 88,573 | Jan 03, 2018, 05:18 PM |
| Kafka Steven J. | President & COO | Jan 02, 2018 | Sale | $64.00 | 157 | 10,048 | 90,830 | Jan 03, 2018, 05:18 PM |
| Hesslein Robert W. | SVP and General Counsel | Jan 02, 2018 | Sale | $64.00 | 1,864 | 119,296 | 116,836 | Jan 03, 2018, 05:18 PM |
| Civik Thomas | Chief Commercial Officer | Jan 01, 2018 | Option Exercise | $68.20 | 33,421 | 2,279,312 | 33,421 | Jan 03, 2018, 04:07 PM |
| Ryan Jason | Chief Financial Officer | Jan 02, 2018 | Sale | $64.00 | 2,336 | 149,504 | 51,209 | Jan 03, 2018, 12:00 AM |
| Pellini Michael J | Director | Dec 07, 2017 | Option Exercise | $62.25 | 2,500 | 155,625 | 234,728 | Dec 15, 2017, 04:03 PM |
| Pellini Michael J | Director | Dec 13, 2017 | Sale | $61.71 | 48,746 | 3,008,116 | 185,982 | Dec 15, 2017, 04:03 PM |
| JONES EVAN/ FA | Director | Dec 13, 2017 | Sale | $62.05 | 1,400 | 86,870 | 17,652 | Dec 15, 2017, 04:02 PM |
| Kafka Steven J. | President & COO | Dec 07, 2017 | Option Exercise | $5.34 | 88,361 | 471,644 | 141,883 | Dec 11, 2017, 04:03 PM |
| Kafka Steven J. | President & COO | Dec 07, 2017 | Sale | $61.66 | 88,361 | 5,448,339 | 90,987 | Dec 11, 2017, 04:03 PM |
| Ryan Jason | Chief Financial Officer | Dec 05, 2017 | Option Exercise | $6.14 | 21,726 | 133,302 | 71,289 | Dec 07, 2017, 04:05 PM |
| Ryan Jason | Chief Financial Officer | Dec 05, 2017 | Sale | $61.26 | 21,726 | 1,330,935 | 52,601 | Dec 07, 2017, 04:05 PM |
| Pellini Michael J | Director | Dec 06, 2017 | Sale | $58.11 | 20,947 | 1,217,230 | 237,228 | Dec 07, 2017, 04:04 PM |
| Pellini Michael J | Director | Dec 05, 2017 | Sale | $61.47 | 9,053 | 556,488 | 258,175 | Dec 07, 2017, 04:04 PM |
| Miller Vincent A. | Chief Medical Officer | Dec 05, 2017 | Sale | $61.17 | 20,000 | 1,223,400 | 99,984 | Dec 07, 2017, 04:04 PM |
| Kafka Steven J. | President & COO | Dec 06, 2017 | Option Exercise | $4.16 | 5,774 | 24,020 | 96,761 | Dec 07, 2017, 04:03 PM |
| Kafka Steven J. | President & COO | Dec 06, 2017 | Sale | $58.57 | 5,774 | 338,183 | 90,987 | Dec 07, 2017, 04:03 PM |
| JONES EVAN/ FA | Director | Dec 06, 2017 | Sale | $57.88 | 600 | 34,728 | 19,052 | Dec 07, 2017, 04:03 PM |
| JONES EVAN/ FA | Director | Dec 05, 2017 | Sale | $60.94 | 5,900 | 359,546 | 19,652 | Dec 07, 2017, 04:03 PM |
| Ryan Jason | Chief Financial Officer | Nov 02, 2017 | Sale | $50.00 | 9,731 | 486,550 | 52,601 | Nov 06, 2017, 04:02 PM |
| Kafka Steven J. | President & COO | Oct 13, 2017 | Sale | $44.62 | 3,361 | 149,968 | 90,987 | Oct 16, 2017, 04:10 PM |
| Ryan Jason | Chief Financial Officer | Oct 12, 2017 | Sale | $45.05 | 1,152 | 51,898 | 62,332 | Oct 16, 2017, 04:10 PM |
| Ryan Jason | Chief Financial Officer | Oct 02, 2017 | Sale | $38.80 | 3,154 | 122,375 | 64,809 | Oct 04, 2017, 04:05 PM |
| Pellini Michael J | Director | Oct 02, 2017 | Sale | $38.80 | 4,349 | 168,741 | 267,228 | Oct 04, 2017, 04:04 PM |
| Nallicheri Melanie | Chief Business Officer | Oct 02, 2017 | Sale | $38.80 | 5,440 | 211,072 | 59,271 | Oct 04, 2017, 04:04 PM |
| Miller Vincent A. | Chief Medical Officer | Oct 02, 2017 | Sale | $38.80 | 2,944 | 114,227 | 122,603 | Oct 04, 2017, 04:03 PM |
| Kafka Steven J. | President & COO | Oct 02, 2017 | Sale | $38.80 | 3,201 | 124,199 | 97,396 | Oct 04, 2017, 04:02 PM |
| Hesslein Robert W. | SVP and General Counsel | Oct 02, 2017 | Sale | $38.80 | 2,165 | 84,002 | 118,891 | Oct 04, 2017, 04:02 PM |
| Yeshwant Krishna | Director | Aug 08, 2017 | Sale | $40.01 | 4,800 | 192,048 | 5,786 | Aug 10, 2017, 04:07 PM |
| Pellini Michael J | Director | Aug 09, 2017 | Option Exercise | $39.15 | 3,500 | 137,025 | 271,577 | Aug 10, 2017, 04:06 PM |
| Pellini Michael J | Director | Aug 09, 2017 | Sale | $39.52 | 30,000 | 1,185,600 | 275,077 | Aug 10, 2017, 04:06 PM |
| Daly David | Chief Commercial Officer | Aug 09, 2017 | Option Exercise | $22.24 | 46,872 | 1,042,433 | 163,133 | Aug 10, 2017, 04:06 PM |
| Daly David | Chief Commercial Officer | Aug 09, 2017 | Sale | $39.50 | 46,872 | 1,851,444 | 116,261 | Aug 10, 2017, 04:06 PM |
| Yeshwant Krishna | Director | Aug 04, 2017 | Option Exercise | $37.75 | 8,585 | 324,084 | 10,586 | Aug 08, 2017, 04:04 PM |
| Yeshwant Krishna | Director | Aug 04, 2017 | Option Exercise | $24.21 | 13,385 | 324,051 | 19,171 | Aug 08, 2017, 04:04 PM |
| Yeshwant Krishna | Director | Aug 04, 2017 | Sale | $36.85 | 18,072 | 665,953 | 5,786 | Aug 08, 2017, 04:04 PM |
| Ryan Jason | Chief Financial Officer | Jul 13, 2017 | Sale | $39.77 | 5,084 | 202,191 | 66,638 | Jul 17, 2017, 04:02 PM |
| Kafka Steven J. | President & COO | Jul 14, 2017 | Sale | $39.15 | 11,781 | 461,226 | 97,549 | Jul 17, 2017, 04:01 PM |
| Ryan Jason | Chief Financial Officer | Jul 06, 2017 | Sale | $38.84 | 6,683 | 259,568 | 74,836 | Jul 07, 2017, 04:04 PM |
| Pellini Michael J | Director | Jul 06, 2017 | Sale | $38.84 | 15,856 | 615,847 | 309,373 | Jul 07, 2017, 04:03 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 06, 2017 | Sale | $38.84 | 5,408 | 210,047 | 128,076 | Jul 07, 2017, 04:03 PM |
| Kafka Steven J. | President & COO | Jul 06, 2017 | Sale | $38.84 | 7,398 | 287,338 | 116,624 | Jul 07, 2017, 04:02 PM |
| Kafka Steven J. | President & COO | Jul 05, 2017 | Sale | $38.98 | 12,310 | 479,844 | 116,728 | Jul 07, 2017, 04:02 PM |
| Hesslein Robert W. | SVP and General Counsel | Jul 06, 2017 | Sale | $38.84 | 5,070 | 196,919 | 122,091 | Jul 07, 2017, 04:02 PM |
| Daly David | Chief Commercial Officer | Jul 06, 2017 | Sale | $38.84 | 6,316 | 245,313 | 119,748 | Jul 07, 2017, 04:01 PM |
| Yeshwant Krishna | Director | Jun 20, 2017 | Option Exercise | $40.05 | 5,786 | 231,729 | 23,858 | Jun 22, 2017, 04:06 PM |
| JONES EVAN/ FA | Director | Jun 20, 2017 | Option Exercise | $40.05 | 5,786 | 231,729 | 25,552 | Jun 22, 2017, 04:06 PM |
| DOUGHERTY MICHAEL R | Director | Jun 20, 2017 | Option Exercise | $40.05 | 5,786 | 231,729 | 24,789 | Jun 22, 2017, 04:05 PM |
| Borisy Alexis | Director | Jun 20, 2017 | Option Exercise | $40.05 | 5,786 | 231,729 | 73,173 | Jun 22, 2017, 04:04 PM |
| Hesslein Robert W. | SVP and General Counsel | Jun 08, 2017 | Option Exercise | $5.15 | 7,033 | 36,196 | 125,463 | Jun 12, 2017, 04:21 PM |
| Ryan Jason | Chief Financial Officer | Jun 02, 2017 | Sale | $40.00 | 5,573 | 222,920 | 78,405 | Jun 06, 2017, 04:33 PM |
| Daly David | Chief Commercial Officer | Jun 01, 2017 | Sale | $38.30 | 555 | 21,256 | 122,577 | Jun 05, 2017, 04:01 PM |
| Hesslein Robert W. | SVP and General Counsel | May 12, 2017 | Sale | $33.87 | 1,009 | 34,175 | 118,430 | May 16, 2017, 04:06 PM |
| Ryan Jason | Chief Financial Officer | May 01, 2017 | Option Exercise | $35.80 | 32,734 | 1,171,877 | 83,978 | May 03, 2017, 04:02 PM |
| Miller Vincent A. | Chief Medical Officer | May 01, 2017 | Option Exercise | $35.80 | 24,550 | 878,890 | 128,336 | May 03, 2017, 04:02 PM |
| Hesslein Robert W. | SVP and General Counsel | May 01, 2017 | Option Exercise | $35.80 | 16,367 | 585,939 | 119,439 | May 03, 2017, 04:01 PM |
| Daly David | Chief Commercial Officer | May 01, 2017 | Option Exercise | $35.80 | 24,550 | 878,890 | 123,132 | May 03, 2017, 04:01 PM |
| Ryan Jason | Chief Financial Officer | Apr 18, 2017 | Sale | $34.55 | 503 | 17,379 | 51,244 | Apr 20, 2017, 04:06 PM |
| Kafka Steven J. | President & COO | Apr 18, 2017 | Sale | $34.55 | 4,405 | 152,193 | 129,038 | Apr 20, 2017, 04:06 PM |
| Ryan Jason | Chief Financial Officer | Apr 03, 2017 | Sale | $31.96 | 1,233 | 39,407 | 51,747 | Apr 05, 2017, 04:07 PM |
| Pellini Michael J | Director | Apr 03, 2017 | Sale | $31.96 | 1,700 | 54,332 | 320,933 | Apr 05, 2017, 04:06 PM |
| Miller Vincent A. | Chief Medical Officer | Mar 13, 2017 | Option Exercise | $32.70 | 1,000 | 32,700 | 105,139 | Apr 05, 2017, 04:06 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 03, 2017 | Sale | $31.96 | 1,353 | 43,242 | 104,882 | Apr 05, 2017, 04:06 PM |
| Kafka Steven J. | President & COO | Apr 03, 2017 | Sale | $31.96 | 2,157 | 68,938 | 135,497 | Apr 05, 2017, 04:05 PM |
| Hesslein Robert W. | SVP and General Counsel | Apr 03, 2017 | Sale | $31.96 | 1,233 | 39,407 | 103,072 | Apr 05, 2017, 04:05 PM |
| Daly David | Chief Commercial Officer | Apr 03, 2017 | Sale | $31.96 | 2,070 | 66,157 | 98,582 | Apr 05, 2017, 04:04 PM |
| Ryan Jason | Chief Financial Officer | Mar 16, 2017 | Option Exercise | $3.30 | 12,500 | 41,210 | 65,480 | Mar 20, 2017, 04:03 PM |
| Ryan Jason | Chief Financial Officer | Mar 16, 2017 | Sale | $31.68 | 12,500 | 396,000 | 52,980 | Mar 20, 2017, 04:03 PM |
| Hesslein Robert W. | SVP and General Counsel | Mar 16, 2017 | Sale | $31.67 | 6,231 | 197,336 | 104,305 | Mar 20, 2017, 04:02 PM |
| Pellini Michael J | Director | Mar 08, 2017 | Option Exercise | $7.12 | 9,489 | 67,562 | 332,122 | Mar 09, 2017, 04:10 PM |
| Pellini Michael J | Director | Mar 07, 2017 | Option Exercise | $7.12 | 30,511 | 217,238 | 353,144 | Mar 09, 2017, 04:10 PM |
| Pellini Michael J | Director | Mar 08, 2017 | Sale | $34.28 | 9,489 | 325,283 | 322,633 | Mar 09, 2017, 04:10 PM |
| Pellini Michael J | Director | Mar 07, 2017 | Sale | $34.31 | 30,511 | 1,046,832 | 322,633 | Mar 09, 2017, 04:10 PM |
| Kafka Steven J. | President & COO | Feb 06, 2017 | Option Exercise | $18.92 | 52,855 | 1,000,017 | 146,015 | Feb 08, 2017, 04:10 PM |
| Kafka Steven J. | President & COO | Feb 08, 2017 | Sale | $23.24 | 10,415 | 242,045 | 135,600 | Feb 08, 2017, 04:10 PM |
| Cox Troy | Chief Executive Officer | Feb 06, 2017 | Option Exercise | $18.92 | 251,058 | 4,750,017 | 251,058 | Feb 08, 2017, 04:09 PM |
| Ryan Jason | Chief Financial Officer | Jan 13, 2017 | Sale | $19.00 | 1,777 | 33,763 | 52,980 | Jan 18, 2017, 04:16 PM |
| Ryan Jason | Chief Financial Officer | Jan 04, 2017 | Sale | $18.49 | 1,426 | 26,367 | 54,757 | Jan 05, 2017, 04:10 PM |
| Ryan Jason | Chief Financial Officer | Jan 03, 2017 | Sale | $17.41 | 3,239 | 56,391 | 56,183 | Jan 05, 2017, 04:10 PM |
| Pellini Michael J | Chief Executive Officer | Jan 04, 2017 | Sale | $18.49 | 3,491 | 64,549 | 322,633 | Jan 05, 2017, 04:09 PM |
| Pellini Michael J | Chief Executive Officer | Jan 03, 2017 | Sale | $17.41 | 11,146 | 194,052 | 326,124 | Jan 05, 2017, 04:09 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 03, 2017 | Sale | $17.41 | 3,506 | 61,039 | 107,665 | Jan 05, 2017, 04:08 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 04, 2017 | Sale | $18.49 | 1,267 | 23,427 | 106,139 | Jan 05, 2017, 04:08 PM |
| Kafka Steven J. | President & COO | Jan 04, 2017 | Sale | $18.49 | 2,376 | 43,932 | 93,160 | Jan 05, 2017, 04:07 PM |
| Kafka Steven J. | President & COO | Jan 03, 2017 | Sale | $17.41 | 6,014 | 104,704 | 95,686 | Jan 05, 2017, 04:07 PM |
| Hesslein Robert W. | SVP and General Counsel | Jan 04, 2017 | Sale | $18.49 | 1,426 | 26,367 | 110,536 | Jan 05, 2017, 04:07 PM |
| Hesslein Robert W. | SVP and General Counsel | Jan 03, 2017 | Sale | $17.41 | 3,256 | 56,687 | 111,962 | Jan 05, 2017, 04:07 PM |
| Daly David | Chief Commercial Officer | Dec 01, 2016 | Sale | $19.95 | 564 | 11,252 | 106,290 | Dec 05, 2016, 04:02 PM |
| Kafka Steven J. | President & COO | Nov 22, 2016 | Option Exercise | $4.16 | 4,814 | 20,026 | 106,239 | Nov 22, 2016, 06:18 PM |
| Kafka Steven J. | President & COO | Nov 18, 2016 | Option Exercise | $4.16 | 1,459 | 6,069 | 103,009 | Nov 22, 2016, 06:18 PM |
| Kafka Steven J. | President & COO | Nov 22, 2016 | Sale | $23.00 | 4,814 | 110,722 | 101,550 | Nov 22, 2016, 06:18 PM |
| Kafka Steven J. | President & COO | Nov 18, 2016 | Sale | $23.06 | 1,459 | 33,645 | 101,550 | Nov 22, 2016, 06:18 PM |
| Kafka Steven J. | President & COO | Nov 16, 2016 | Option Exercise | $4.16 | 1,000 | 4,160 | 102,550 | Nov 18, 2016, 04:05 PM |
| Kafka Steven J. | President & COO | Nov 16, 2016 | Sale | $23.00 | 1,000 | 23,000 | 101,550 | Nov 18, 2016, 04:05 PM |
| DOUGHERTY MICHAEL R | Director | Oct 26, 2016 | Option Exercise | $23.55 | 19,003 | 447,521 | 19,003 | Oct 28, 2016, 04:10 PM |
| Ryan Jason | Chief Financial Officer | Oct 20, 2016 | Sale | $22.45 | 506 | 11,360 | 59,422 | Oct 24, 2016, 04:03 PM |
| Kafka Steven J. | President & COO | Oct 20, 2016 | Sale | $23.00 | 4,427 | 101,821 | 101,550 | Oct 24, 2016, 04:01 PM |
| Ryan Jason | Chief Financial Officer | Oct 04, 2016 | Sale | $23.65 | 1,220 | 28,853 | 59,928 | Oct 05, 2016, 04:09 PM |
| Pellini Michael J | Chief Executive Officer | Oct 04, 2016 | Sale | $23.65 | 2,629 | 62,176 | 337,270 | Oct 05, 2016, 04:08 PM |
| Miller Vincent A. | Chief Medical Officer | Sep 13, 2016 | Option Exercise | $21.74 | 1,400 | 30,436 | 112,254 | Oct 05, 2016, 04:07 PM |
| Miller Vincent A. | Chief Medical Officer | Oct 04, 2016 | Sale | $23.65 | 1,084 | 25,637 | 110,912 | Oct 05, 2016, 04:07 PM |
| Miller Vincent A. | Chief Medical Officer | Oct 03, 2016 | Sale | $23.04 | 258 | 5,944 | 111,996 | Oct 05, 2016, 04:07 PM |
| Kafka Steven J. | President & COO | Oct 04, 2016 | Sale | $23.65 | 2,032 | 48,057 | 105,977 | Oct 05, 2016, 04:06 PM |
| Kafka Steven J. | President & COO | Oct 03, 2016 | Sale | $23.04 | 103 | 2,373 | 108,009 | Oct 05, 2016, 04:06 PM |
| Hesslein Robert W. | SVP and General Counsel | Oct 04, 2016 | Sale | $23.65 | 1,220 | 28,853 | 115,218 | Oct 05, 2016, 04:05 PM |
| Daly David | Chief Commercial Officer | Oct 04, 2016 | Sale | $23.65 | 2,045 | 48,364 | 106,854 | Oct 05, 2016, 04:04 PM |
| Kafka Steven J. | President & COO | Sep 20, 2016 | Option Exercise | $4.16 | 7,850 | 32,656 | 113,618 | Sep 22, 2016, 04:36 PM |
| Kafka Steven J. | President & COO | Sep 20, 2016 | Sale | $23.70 | 9,469 | 224,415 | 108,112 | Sep 22, 2016, 04:36 PM |
| Daly David | Chief Commercial Officer | Sep 01, 2016 | Sale | $20.48 | 551 | 11,284 | 108,899 | Sep 06, 2016, 04:23 PM |
| Ryan Jason | Chief Financial Officer | Aug 19, 2016 | Option Exercise | $7.12 | 5,000 | 35,600 | 66,148 | Aug 23, 2016, 04:03 PM |
| Ryan Jason | Chief Financial Officer | Aug 19, 2016 | Sale | $23.92 | 13,863 | 331,614 | 61,148 | Aug 23, 2016, 04:03 PM |
| Hesslein Robert W. | SVP and General Counsel | Aug 09, 2016 | Option Exercise | $5.15 | 9,377 | 48,255 | 116,438 | Aug 11, 2016, 04:06 PM |
| Kafka Steven J. | President & COO | Aug 05, 2016 | Option Exercise | $4.16 | 10,000 | 41,600 | 119,731 | Aug 09, 2016, 04:20 PM |
| Kafka Steven J. | President & COO | Aug 05, 2016 | Sale | $24.16 | 10,000 | 241,600 | 109,731 | Aug 09, 2016, 04:20 PM |
| Ryan Jason | Chief Financial Officer | Jul 01, 2016 | Sale | $17.39 | 3,417 | 59,422 | 71,281 | Jul 06, 2016, 04:07 PM |
| Ryan Jason | Chief Financial Officer | Jul 05, 2016 | Sale | $18.26 | 1,270 | 23,190 | 70,011 | Jul 06, 2016, 04:07 PM |
| Pellini Michael J | Chief Executive Officer | Jul 05, 2016 | Sale | $18.27 | 2,739 | 50,042 | 339,899 | Jul 06, 2016, 04:06 PM |
| Pellini Michael J | Chief Executive Officer | Jul 01, 2016 | Sale | $17.39 | 7,421 | 129,051 | 342,638 | Jul 06, 2016, 04:06 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 05, 2016 | Sale | $18.26 | 1,129 | 20,616 | 113,654 | Jul 06, 2016, 04:05 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 01, 2016 | Sale | $17.40 | 3,699 | 64,360 | 118,209 | Jul 06, 2016, 04:05 PM |
| Kafka Steven J. | President & COO | Jul 01, 2016 | Sale | $17.39 | 4,378 | 76,135 | 116,117 | Jul 06, 2016, 04:05 PM |
| Kafka Steven J. | President & COO | Jul 05, 2016 | Sale | $18.26 | 2,117 | 38,656 | 109,731 | Jul 06, 2016, 04:05 PM |
| Hesslein Robert W. | SVP and General Counsel | Jul 05, 2016 | Sale | $18.26 | 1,270 | 23,190 | 107,061 | Jul 06, 2016, 04:04 PM |
| Hesslein Robert W. | SVP and General Counsel | Jul 01, 2016 | Sale | $17.39 | 3,435 | 59,735 | 108,331 | Jul 06, 2016, 04:04 PM |
| Daly David | Chief Commercial Officer | Jul 05, 2016 | Sale | $18.26 | 2,130 | 38,894 | 109,450 | Jul 06, 2016, 04:03 PM |
| Daly David | Chief Commercial Officer | Jul 01, 2016 | Sale | $17.39 | 2,878 | 50,048 | 111,580 | Jul 06, 2016, 04:03 PM |
| Yeshwant Krishna | Director | Jun 16, 2016 | Option Exercise | $19.93 | 12,075 | 240,655 | 18,072 | Jun 20, 2016, 04:40 PM |
| Schenkein David P | Director | Jun 16, 2016 | Option Exercise | $19.93 | 12,075 | 240,655 | 23,326 | Jun 20, 2016, 04:08 PM |
| JONES EVAN/ FA | Director | Jun 16, 2016 | Option Exercise | $19.93 | 12,075 | 240,655 | 19,766 | Jun 20, 2016, 04:07 PM |
| Borisy Alexis | Director | Jun 16, 2016 | Option Exercise | $19.93 | 12,075 | 240,655 | 67,387 | Jun 20, 2016, 04:06 PM |
| Daly David | Chief Commercial Officer | Jun 03, 2016 | Sale | $21.66 | 472 | 10,224 | 114,458 | Jun 07, 2016, 04:06 PM |
| Ryan Jason | Chief Financial Officer | Apr 01, 2016 | Option Exercise | $18.25 | 45,000 | 821,250 | 74,698 | Apr 06, 2016, 04:13 PM |
| Pellini Michael J | Chief Executive Officer | Apr 01, 2016 | Option Exercise | $18.25 | 90,000 | 1,642,500 | 350,059 | Apr 06, 2016, 04:13 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 01, 2016 | Option Exercise | $18.25 | 40,000 | 730,000 | 118,482 | Apr 06, 2016, 04:09 PM |
| Kafka Steven J. | President & COO | Apr 01, 2016 | Option Exercise | $18.25 | 75,000 | 1,368,750 | 116,226 | Apr 06, 2016, 04:04 PM |
| Hesslein Robert W. | SVP and General Counsel | Apr 01, 2016 | Option Exercise | $18.25 | 45,000 | 821,250 | 111,766 | Apr 06, 2016, 04:03 PM |
| Daly David | Chief Commercial Officer | Apr 01, 2016 | Option Exercise | $18.25 | 70,000 | 1,277,500 | 114,930 | Apr 06, 2016, 04:02 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 01, 2016 | Sale | $18.08 | 356 | 6,436 | 78,482 | Apr 05, 2016, 04:16 PM |
| Kafka Steven J. | President & COO | Apr 01, 2016 | Sale | $18.08 | 124 | 2,242 | 41,226 | Apr 05, 2016, 04:15 PM |
| Daly David | Chief Commercial Officer | Mar 01, 2016 | Sale | $15.14 | 701 | 10,613 | 44,930 | Mar 03, 2016, 04:10 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 04, 2016 | Sale | $19.88 | 328 | 6,521 | 78,838 | Jan 06, 2016, 04:07 PM |
| Kafka Steven J. | President & COO | Jan 04, 2016 | Sale | $19.88 | 112 | 2,227 | 41,350 | Jan 06, 2016, 04:07 PM |
| Pellini Michael J | Chief Executive Officer | Dec 15, 2015 | Option Exercise | $17.46 | 86,034 | 1,502,154 | 260,059 | Dec 23, 2015, 04:33 PM |
| Daly David | Chief Commercial Officer | Dec 01, 2015 | Sale | $16.78 | 2,559 | 42,946 | 45,631 | Dec 03, 2015, 04:05 PM |
| Pellini Michael J | Chief Executive Officer | Nov 13, 2015 | Buy | $16.43 | 9,100 | 149,555 | 174,025 | Nov 17, 2015, 04:09 PM |
| Miller Vincent A. | Chief Medical Officer | Oct 01, 2015 | Sale | $18.28 | 313 | 5,722 | 79,166 | Oct 05, 2015, 04:36 PM |
| Kafka Steven J. | President & COO | Oct 01, 2015 | Sale | $18.28 | 107 | 1,956 | 41,462 | Oct 05, 2015, 04:36 PM |
| Ryan Jason | Chief Financial Officer | Jul 15, 2015 | Option Exercise | $32.74 | 29,698 | 972,313 | 29,698 | Jul 17, 2015, 04:10 PM |
| Pellini Michael J | Chief Executive Officer | Jul 15, 2015 | Option Exercise | $32.74 | 59,365 | 1,943,610 | 164,925 | Jul 17, 2015, 04:09 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 15, 2015 | Option Exercise | $32.74 | 29,772 | 974,735 | 79,479 | Jul 17, 2015, 04:09 PM |
| Kafka Steven J. | President & COO | Jul 15, 2015 | Option Exercise | $32.74 | 37,103 | 1,214,752 | 41,569 | Jul 17, 2015, 04:08 PM |
| Hesslein Robert W. | SVP and General Counsel | Jul 15, 2015 | Option Exercise | $32.74 | 29,854 | 977,420 | 66,766 | Jul 17, 2015, 04:08 PM |
| Daly David | Chief Commercial Officer | Jul 15, 2015 | Option Exercise | $32.74 | 23,190 | 759,241 | 48,190 | Jul 17, 2015, 04:07 PM |
| Hesslein Robert W. | SVP and General Counsel | Jul 08, 2015 | Option Exercise | $5.15 | 4,687 | 24,124 | 36,912 | Jul 10, 2015, 04:03 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 01, 2015 | Sale | $33.90 | 312 | 10,577 | 49,707 | Jul 06, 2015, 04:07 PM |
| Kafka Steven J. | President & COO | Jul 01, 2015 | Sale | $33.90 | 107 | 3,627 | 4,466 | Jul 06, 2015, 04:06 PM |
| Yeshwant Krishna | Director | Jun 18, 2015 | Option Exercise | $32.23 | 5,997 | 193,283 | 5,997 | Jun 22, 2015, 04:03 PM |
| Schenkein David P | Director | Jun 18, 2015 | Option Exercise | $32.23 | 5,997 | 193,283 | 11,251 | Jun 22, 2015, 04:02 PM |
| JONES EVAN/ FA | Director | Jun 18, 2015 | Option Exercise | $32.23 | 5,997 | 193,283 | 7,691 | Jun 22, 2015, 04:02 PM |
| Borisy Alexis | Director | Jun 18, 2015 | Option Exercise | $32.23 | 5,997 | 193,283 | 55,312 | Jun 22, 2015, 04:01 PM |
| Google Ventures 2011 GP, L.L.C. | 10% Owner | Jun 15, 2015 | Sale | $32.33 | 114,481 | 3,701,171 | 0 | Jun 15, 2015, 08:10 PM |
| Google Ventures 2011 GP, L.L.C. | 10% Owner | Jun 12, 2015 | Sale | $33.72 | 53,645 | 1,808,909 | 114,481 | Jun 15, 2015, 08:10 PM |
| Google Ventures 2011 GP, L.L.C. | 10% Owner | Jun 11, 2015 | Sale | $35.14 | 15,734 | 552,893 | 168,126 | Jun 15, 2015, 08:10 PM |
| Yeshwant Krishna | Director | Jun 15, 2015 | Sale | $32.33 | 114,481 | 3,701,171 | 0 | Jun 15, 2015, 08:09 PM |
| Yeshwant Krishna | Director | Jun 12, 2015 | Sale | $33.72 | 53,645 | 1,808,909 | 114,481 | Jun 15, 2015, 08:09 PM |
| Yeshwant Krishna | Director | Jun 11, 2015 | Sale | $35.14 | 15,734 | 552,893 | 168,126 | Jun 15, 2015, 08:09 PM |
| Yeshwant Krishna | Director | May 14, 2015 | Sale | $38.57 | 8,600 | 331,702 | 183,860 | May 18, 2015, 08:59 PM |
| Google Ventures 2011 GP, L.L.C. | 10% Owner | May 14, 2015 | Sale | $38.57 | 8,600 | 331,702 | 183,860 | May 18, 2015, 08:59 PM |
| Pellini Michael J | Chief Executive Officer | May 12, 2015 | Sale | $40.24 | 17,500 | 704,231 | 105,560 | May 14, 2015, 04:37 PM |
| Yeshwant Krishna | Director | Apr 07, 2015 | Option Exercise | $50.00 | 952,192 | 47,609,600 | 192,460 | Apr 16, 2015, 07:19 PM |
| Borisy Alexis | Director | Apr 07, 2015 | Sale | $50.00 | 241,768 | 12,088,400 | 48,867 | Apr 16, 2015, 11:16 AM |
| THIRD ROCK VENTURES LP | 10% Owner | Apr 07, 2015 | Sale | $50.00 | 4,098,778 | 204,938,900 | 828,456 | Apr 16, 2015, 11:15 AM |
| Schenkein David P | Director | Apr 07, 2015 | Option Exercise | $50.00 | 25,996 | 1,299,800 | 5,254 | Apr 14, 2015, 06:26 PM |
| Schenkein David P | Director | Apr 07, 2015 | Option Exercise | $50.00 | 25,996 | 1,299,800 | 5,254 | Apr 14, 2015, 06:26 PM |
| Schenkein David P | Director | Apr 07, 2015 | Option Exercise | $50.00 | 25,996 | 1,299,800 | 5,254 | Apr 14, 2015, 06:26 PM |
| Pellini Michael J | Chief Executive Officer | Apr 07, 2015 | Option Exercise | $50.00 | 394,700 | 19,735,000 | 123,060 | Apr 14, 2015, 06:25 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 07, 2015 | Option Exercise | $50.00 | 64,440 | 3,222,000 | 50,019 | Apr 14, 2015, 06:19 PM |
| BYERS BROOK H | Director | Apr 07, 2015 | Option Exercise | $50.00 | 816 | 40,800 | 165 | Apr 14, 2015, 06:18 PM |
| BYERS BROOK H | Director | Apr 07, 2015 | Option Exercise | $50.00 | 12,421 | 621,050 | 2,510 | Apr 14, 2015, 06:18 PM |
| BYERS BROOK H | Director | Apr 07, 2015 | Option Exercise | $50.00 | 2,348,194 | 117,409,700 | 437,602 | Apr 14, 2015, 06:18 PM |
| BYERS BROOK H | Director | Apr 07, 2015 | Option Exercise | $50.00 | 816 | 40,800 | 165 | Apr 14, 2015, 06:18 PM |
| Kleiner Perkins Caufield & Byers XIV, LLC | 10% Owner | Apr 07, 2015 | Option Exercise | $50.00 | 2,348,194 | 117,409,700 | 437,602 | Apr 14, 2015, 06:17 PM |
| JONES EVAN/ FA | Director | Apr 07, 2015 | Option Exercise | $50.00 | 46,009 | 2,300,450 | 9,300 | Apr 14, 2015, 06:16 PM |
| JONES EVAN/ FA | Director | Apr 07, 2015 | Option Exercise | $50.00 | 8,382 | 419,100 | 1,694 | Apr 14, 2015, 06:16 PM |
| Hesslein Robert W. | SVP and General Counsel | Apr 07, 2015 | Option Exercise | $50.00 | 35,900 | 1,795,000 | 32,225 | Apr 14, 2015, 06:15 PM |
| Yeshwant Krishna | Director | Apr 07, 2015 | Option Exercise | $50.00 | 923,735 | 46,186,750 | 220,917 | Apr 09, 2015, 06:39 PM |
| Schenkein David P | Director | Apr 07, 2015 | Option Exercise | $50.00 | 25,218 | 1,260,900 | 6,032 | Apr 09, 2015, 05:35 PM |
| Schenkein David P | Director | Apr 07, 2015 | Option Exercise | $50.00 | 25,218 | 1,260,900 | 6,032 | Apr 09, 2015, 05:35 PM |
| Schenkein David P | Director | Apr 07, 2015 | Option Exercise | $50.00 | 25,218 | 1,260,900 | 6,032 | Apr 09, 2015, 05:35 PM |
| Kleiner Perkins Caufield & Byers XIV, LLC | 10% Owner | Apr 07, 2015 | Option Exercise | $50.00 | 2,278,012 | 113,900,600 | 502,309 | Apr 09, 2015, 05:00 PM |
| BYERS BROOK H | Director | Apr 07, 2015 | Option Exercise | $50.00 | 791 | 39,550 | 190 | Apr 09, 2015, 05:00 PM |
| BYERS BROOK H | Director | Apr 07, 2015 | Option Exercise | $50.00 | 12,049 | 602,450 | 2,882 | Apr 09, 2015, 05:00 PM |
| BYERS BROOK H | Director | Apr 07, 2015 | Option Exercise | $50.00 | 2,278,012 | 113,900,600 | 502,309 | Apr 09, 2015, 05:00 PM |
| BYERS BROOK H | Director | Apr 07, 2015 | Option Exercise | $50.00 | 791 | 39,550 | 190 | Apr 09, 2015, 05:00 PM |
| JONES EVAN/ FA | Director | Apr 07, 2015 | Option Exercise | $50.00 | 44,634 | 2,231,700 | 10,675 | Apr 09, 2015, 04:58 PM |
| JONES EVAN/ FA | Director | Apr 07, 2015 | Option Exercise | $50.00 | 8,131 | 406,550 | 1,945 | Apr 09, 2015, 04:58 PM |
| Hesslein Robert W. | SVP and General Counsel | Apr 07, 2015 | Option Exercise | $50.00 | 35,020 | 1,751,000 | 33,105 | Apr 09, 2015, 04:57 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 07, 2015 | Option Exercise | $50.00 | 62,514 | 3,125,700 | 51,945 | Apr 09, 2015, 04:55 PM |
| Pellini Michael J | Chief Executive Officer | Apr 07, 2015 | Option Exercise | $50.00 | 382,903 | 19,145,150 | 134,857 | Apr 09, 2015, 04:54 PM |
| Borisy Alexis | Director | Apr 07, 2015 | Sale | $50.00 | 234,542 | 11,727,100 | 56,093 | Apr 09, 2015, 04:43 PM |
| THIRD ROCK VENTURES LP | 10% Owner | Apr 07, 2015 | Sale | $50.00 | 3,976,278 | 198,813,900 | 950,956 | Apr 09, 2015, 04:41 PM |
| ROCHE HOLDINGS INC | Director | Apr 07, 2015 | Option Exercise | $50.00 | 5,000,000 | 250,000,000 | 5,000,000 | Apr 09, 2015, 08:54 AM |
| ROCHE HOLDINGS INC | Director | Apr 07, 2015 | Buy | $50.00 | 15,604,288 | 780,214,400 | 20,604,288 | Apr 09, 2015, 08:54 AM |
| Miller Vincent A. | Chief Medical Officer | Apr 01, 2015 | Sale | $47.92 | 356 | 17,060 | 114,459 | Apr 03, 2015, 04:13 PM |
| Kafka Steven J. | President & COO | Apr 01, 2015 | Sale | $47.92 | 107 | 5,127 | 4,573 | Apr 03, 2015, 04:12 PM |
| Pellini Michael J | Chief Executive Officer | Mar 30, 2015 | Sale | $48.48 | 17,500 | 848,323 | 517,760 | Apr 01, 2015, 04:17 PM |
| JONES EVAN/ FA | Director | Mar 16, 2015 | Option Exercise | $5.28 | 10,076 | 53,247 | 10,076 | Mar 17, 2015, 04:08 PM |
| Hesslein Robert W. | SVP and General Counsel | Mar 05, 2015 | Sale | $47.24 | 4,635 | 218,957 | 68,125 | Mar 10, 2015, 04:05 PM |
| Pellini Michael J | President & CEO | Mar 04, 2015 | Option Exercise | $0.84 | 118,516 | 99,553 | 538,516 | Mar 06, 2015, 04:05 PM |
| Pellini Michael J | President & CEO | Mar 05, 2015 | Option Exercise | $2.60 | 150,044 | 390,488 | 622,021 | Mar 06, 2015, 04:05 PM |
| Pellini Michael J | President & CEO | Mar 04, 2015 | Sale | $47.41 | 66,539 | 3,154,394 | 471,977 | Mar 06, 2015, 04:05 PM |
| Pellini Michael J | President & CEO | Mar 05, 2015 | Sale | $47.10 | 86,761 | 4,086,807 | 535,260 | Mar 06, 2015, 04:05 PM |
| Miller Vincent A. | Chief Medical Officer | Mar 03, 2015 | Option Exercise | $4.07 | 32,811 | 133,663 | 116,120 | Mar 05, 2015, 04:11 PM |
| Miller Vincent A. | Chief Medical Officer | Mar 03, 2015 | Sale | $47.81 | 17,058 | 815,616 | 99,062 | Mar 05, 2015, 04:11 PM |
| Kafka Steven J. | Chief Operating Officer | Mar 03, 2015 | Option Exercise | $4.99 | 33,124 | 165,454 | 25,336 | Mar 05, 2015, 04:05 PM |
| Kafka Steven J. | Chief Operating Officer | Mar 03, 2015 | Sale | $47.65 | 33,124 | 1,578,397 | 4,680 | Mar 05, 2015, 04:05 PM |
| Hesslein Robert W. | SVP and General Counsel | Mar 02, 2015 | Option Exercise | $4.82 | 14,059 | 67,735 | 74,184 | Mar 04, 2015, 04:08 PM |
| Hesslein Robert W. | SVP and General Counsel | Mar 02, 2015 | Sale | $48.35 | 1,424 | 68,850 | 72,760 | Mar 04, 2015, 04:08 PM |
| Ryan Jason | Senior Vice President, Finance | Feb 27, 2015 | Option Exercise | $3.38 | 25,000 | 84,430 | 25,000 | Mar 03, 2015, 04:26 PM |
| Ryan Jason | Senior Vice President, Finance | Feb 27, 2015 | Sale | $47.61 | 25,000 | 1,190,265 | 0 | Mar 03, 2015, 04:26 PM |
| Pellini Michael J | President & CEO | Feb 11, 2015 | Sale | $48.56 | 17,500 | 849,852 | 420,000 | Feb 13, 2015, 04:16 PM |
| Ryan Jason | Senior Vice President, Finance | Jun 05, 2014 | Option Exercise | $0.08 | 4,773 | 382 | 4,773 | Feb 05, 2015, 06:45 PM |
| Ryan Jason | Senior Vice President, Finance | Jun 05, 2014 | Sale | $24.20 | 4,773 | 115,498 | 0 | Feb 05, 2015, 06:45 PM |
| Kafka Steven J. | Chief Operating Officer | Jan 15, 2015 | Option Exercise | $6.13 | 15,000 | 92,000 | 14,680 | Jan 20, 2015, 04:15 PM |
| Kafka Steven J. | Chief Operating Officer | Jan 15, 2015 | Sale | $48.38 | 15,000 | 725,673 | 4,680 | Jan 20, 2015, 04:15 PM |
| Pellini Michael J | President & CEO | Jan 12, 2015 | Sale | $51.07 | 22,500 | 1,149,147 | 437,500 | Jan 14, 2015, 04:09 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 12, 2015 | Sale | $53.03 | 2,000 | 106,055 | 99,062 | Jan 14, 2015, 04:09 PM |
| Kafka Steven J. | Chief Operating Officer | Jan 12, 2015 | Option Exercise | $7.12 | 8,000 | 56,960 | 12,680 | Jan 14, 2015, 04:08 PM |
| Kafka Steven J. | Chief Operating Officer | Jan 12, 2015 | Sale | $51.83 | 8,000 | 414,623 | 4,680 | Jan 14, 2015, 04:08 PM |
| Hesslein Robert W. | SVP and General Counsel | Jan 12, 2015 | Sale | $52.11 | 7,000 | 364,781 | 60,125 | Jan 14, 2015, 04:08 PM |
| Hesslein Robert W. | SVP and General Counsel | Jan 08, 2015 | Sale | $23.03 | 4,000 | 92,132 | 67,125 | Jan 12, 2015, 04:02 PM |
| Miller Vincent A. | Chief Medical Officer | Jan 02, 2015 | Sale | $22.25 | 314 | 6,987 | 101,062 | Jan 06, 2015, 04:08 PM |
| Kafka Steven J. | Chief Operating Officer | Jan 02, 2015 | Sale | $22.25 | 107 | 2,381 | 4,680 | Jan 06, 2015, 04:07 PM |
| Pellini Michael J | President & CEO | Dec 29, 2014 | Sale | $23.91 | 12,500 | 298,919 | 460,000 | Dec 31, 2014, 08:27 AM |
| Ryan Jason | Senior Vice President, Finance | Dec 15, 2014 | Option Exercise | $0.08 | 2,361 | 189 | 2,361 | Dec 17, 2014, 04:09 PM |
| Ryan Jason | Senior Vice President, Finance | Dec 15, 2014 | Sale | $21.55 | 2,361 | 50,880 | 0 | Dec 17, 2014, 04:09 PM |
| Daly David | Chief Commercial Officer | Dec 05, 2014 | Option Exercise | $22.24 | 25,000 | 556,000 | 25,000 | Dec 09, 2014, 07:57 AM |
| Ryan Jason | Senior Vice President, Finance | Nov 17, 2014 | Option Exercise | $0.08 | 3,541 | 283 | 3,541 | Nov 19, 2014, 04:05 PM |
| Ryan Jason | Senior Vice President, Finance | Nov 17, 2014 | Sale | $24.90 | 3,541 | 88,185 | 0 | Nov 19, 2014, 04:05 PM |
| Pellini Michael J | President & CEO | Nov 14, 2014 | Sale | $24.84 | 3,000 | 74,519 | 472,500 | Nov 17, 2014, 04:19 PM |
| Pellini Michael J | President & CEO | Nov 13, 2014 | Sale | $24.93 | 9,500 | 236,850 | 475,500 | Nov 17, 2014, 04:19 PM |
| Kafka Steven J. | Chief Operating Officer | Oct 27, 2014 | Option Exercise | $4.16 | 10,000 | 41,600 | 14,787 | Oct 29, 2014, 04:09 PM |
| Kafka Steven J. | Chief Operating Officer | Oct 27, 2014 | Sale | $25.31 | 10,000 | 253,127 | 4,787 | Oct 29, 2014, 04:09 PM |
| Ryan Jason | Senior Vice President, Finance | Oct 27, 2014 | Option Exercise | $0.08 | 2,360 | 189 | 2,360 | Oct 29, 2014, 04:08 PM |
| Ryan Jason | Senior Vice President, Finance | Oct 27, 2014 | Sale | $25.00 | 2,360 | 59,000 | 0 | Oct 29, 2014, 04:08 PM |
| Pellini Michael J | President & CEO | Oct 17, 2014 | Sale | $23.00 | 12,500 | 287,500 | 485,000 | Oct 21, 2014, 04:09 PM |
| Hesslein Robert W. | SVP and General Counsel | Oct 17, 2014 | Sale | $23.18 | 4,000 | 92,733 | 74,125 | Oct 21, 2014, 04:08 PM |
| Ryan Jason | Senior Vice President, Finance | Oct 15, 2014 | Option Exercise | $0.08 | 2,361 | 189 | 2,361 | Oct 17, 2014, 04:07 PM |
| Ryan Jason | Senior Vice President, Finance | Oct 15, 2014 | Sale | $20.09 | 2,361 | 47,432 | 0 | Oct 17, 2014, 04:07 PM |
| Miller Vincent A. | Chief Medical Officer | Oct 01, 2014 | Sale | $18.75 | 314 | 5,888 | 101,376 | Oct 03, 2014, 04:09 PM |
| KRENITSKY KEVIN | Chief Commercial Officer & SVP | Oct 01, 2014 | Sale | $18.75 | 70 | 1,313 | 140,611 | Oct 03, 2014, 04:09 PM |
| Kafka Steven J. | Chief Operating Officer | Oct 01, 2014 | Sale | $18.75 | 107 | 2,006 | 4,787 | Oct 03, 2014, 04:08 PM |
| Ryan Jason | Senior Vice President, Finance | Sep 15, 2014 | Option Exercise | $0.08 | 2,361 | 189 | 2,361 | Sep 16, 2014, 07:03 PM |
| Ryan Jason | Senior Vice President, Finance | Sep 15, 2014 | Sale | $21.92 | 2,361 | 51,750 | 0 | Sep 16, 2014, 07:03 PM |
| Ryan Jason | Senior Vice President, Finance | Aug 15, 2014 | Option Exercise | $0.08 | 3,541 | 283 | 3,541 | Aug 19, 2014, 04:04 PM |
| Ryan Jason | Senior Vice President, Finance | Aug 15, 2014 | Sale | $25.13 | 3,541 | 88,982 | 0 | Aug 19, 2014, 04:04 PM |
| Pellini Michael J | President & CEO | Aug 18, 2014 | Sale | $25.10 | 8,000 | 200,798 | 497,500 | Aug 19, 2014, 04:03 PM |
| Pellini Michael J | President & CEO | Aug 15, 2014 | Sale | $25.61 | 4,500 | 115,266 | 505,500 | Aug 19, 2014, 04:03 PM |
| Kafka Steven J. | Chief Operating Officer | Jul 22, 2014 | Option Exercise | $4.16 | 10,000 | 41,600 | 10,206 | Jul 24, 2014, 06:39 AM |
| Kafka Steven J. | Chief Operating Officer | Jul 22, 2014 | Sale | $27.14 | 10,000 | 271,445 | 206 | Jul 24, 2014, 06:39 AM |
| Ryan Jason | Senior Vice President, Finance | Jul 15, 2014 | Option Exercise | $0.08 | 3,541 | 283 | 3,541 | Jul 17, 2014, 04:06 PM |
| Ryan Jason | Senior Vice President, Finance | Jul 15, 2014 | Sale | $27.22 | 3,541 | 96,387 | 0 | Jul 17, 2014, 04:06 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 15, 2014 | Sale | $27.25 | 15,000 | 408,746 | 102,285 | Jul 17, 2014, 04:06 PM |
| Hesslein Robert W. | SVP and General Counsel | Jul 08, 2014 | Sale | $27.22 | 4,000 | 108,895 | 75,125 | Jul 09, 2014, 04:04 PM |
| Pellini Michael J | President & CEO | Jul 02, 2014 | Sale | $28.00 | 2,500 | 70,000 | 510,000 | Jul 02, 2014, 04:07 PM |
| Pellini Michael J | President & CEO | Jul 01, 2014 | Sale | $27.30 | 12,500 | 341,244 | 512,500 | Jul 02, 2014, 04:07 PM |
| Miller Vincent A. | Chief Medical Officer | Jul 01, 2014 | Sale | $27.20 | 310 | 8,432 | 116,690 | Jul 02, 2014, 04:07 PM |
| KRENITSKY KEVIN | Chief Commercial Officer & SVP | Jul 01, 2014 | Sale | $27.20 | 69 | 1,877 | 140,681 | Jul 02, 2014, 04:06 PM |
| Kafka Steven J. | Chief Operating Officer | Jul 01, 2014 | Sale | $27.20 | 106 | 2,883 | 206 | Jul 02, 2014, 04:06 PM |
| Ryan Jason | Senior Vice President, Finance | Jun 26, 2014 | Option Exercise | $0.08 | 1,180 | 94 | 1,180 | Jun 30, 2014, 04:06 PM |
| Ryan Jason | Senior Vice President, Finance | Jun 26, 2014 | Sale | $25.00 | 1,180 | 29,500 | 0 | Jun 30, 2014, 04:06 PM |
| Kafka Steven J. | Chief Operating Officer | Jun 26, 2014 | Option Exercise | $4.16 | 5,000 | 20,800 | 5,000 | Jun 30, 2014, 04:06 PM |
| Kafka Steven J. | Chief Operating Officer | Jun 26, 2014 | Sale | $25.19 | 5,000 | 125,936 | 0 | Jun 30, 2014, 04:06 PM |
| Kafka Steven J. | Chief Operating Officer | Jun 19, 2014 | Option Exercise | $4.16 | 5,000 | 20,800 | 5,000 | Jun 23, 2014, 04:07 PM |
| Kafka Steven J. | Chief Operating Officer | Jun 19, 2014 | Sale | $24.46 | 5,000 | 122,304 | 0 | Jun 23, 2014, 04:07 PM |
| Ryan Jason | Senior Vice President, Finance | Jun 16, 2014 | Option Exercise | $0.08 | 2,361 | 189 | 2,361 | Jun 18, 2014, 04:14 PM |
| Ryan Jason | Senior Vice President, Finance | Jun 16, 2014 | Sale | $22.61 | 2,361 | 53,391 | 0 | Jun 18, 2014, 04:14 PM |
| Yeshwant Krishna | Director | Jun 13, 2014 | Sale | $22.40 | 1,300,000 | 29,120,000 | 1,144,653 | Jun 17, 2014, 05:20 PM |
| Ryan Jason | Senior Vice President, Finance | Jun 09, 2014 | Option Exercise | $0.08 | 1,180 | 94 | 1,180 | Jun 12, 2014, 06:13 AM |
| Ryan Jason | Senior Vice President, Finance | Jun 09, 2014 | Sale | $25.00 | 1,180 | 29,500 | 0 | Jun 12, 2014, 06:13 AM |
| Pellini Michael J | President & CEO | Jun 04, 2014 | Sale | $23.53 | 25,000 | 588,155 | 525,000 | Jun 06, 2014, 05:46 PM |
| Kafka Steven J. | Chief Operating Officer | Jun 05, 2014 | Option Exercise | $4.16 | 4,500 | 18,720 | 4,500 | Jun 06, 2014, 05:44 PM |
| Kafka Steven J. | Chief Operating Officer | Jun 05, 2014 | Sale | $24.19 | 4,500 | 108,838 | 0 | Jun 06, 2014, 05:44 PM |
| Ryan Jason | Senior Vice President, Finance | Jun 05, 2014 | Option Exercise | $0.08 | 10,000 | 800 | 5,000 | Jun 06, 2014, 05:42 PM |
| Ryan Jason | Senior Vice President, Finance | Jun 05, 2014 | Sale | $24.06 | 10,000 | 240,594 | 0 | Jun 06, 2014, 05:42 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 09, 2014 | Option Exercise | $29.94 | 12,500 | 374,250 | 150,000 | May 27, 2014, 09:34 AM |
| KRENITSKY KEVIN | Chief Commercial Officer & SVP | Apr 09, 2014 | Option Exercise | $29.94 | 3,250 | 97,305 | 140,750 | May 27, 2014, 09:32 AM |
| Kafka Steven J. | Chief Operating Officer | Apr 09, 2014 | Option Exercise | $29.94 | 5,000 | 149,700 | 5,000 | May 27, 2014, 09:29 AM |
| Ryan Jason | Senior Vice President, Finance | May 15, 2014 | Option Exercise | $0.08 | 2,361 | 189 | 2,361 | May 19, 2014, 05:58 PM |
| Ryan Jason | Senior Vice President, Finance | May 15, 2014 | Sale | $20.95 | 2,361 | 49,452 | 0 | May 19, 2014, 05:58 PM |
| Miller Vincent A. | Chief Medical Officer | May 06, 2014 | Sale | $30.00 | 2,800 | 84,000 | 117,000 | May 07, 2014, 04:42 PM |
| Miller Vincent A. | Chief Medical Officer | May 05, 2014 | Sale | $30.00 | 200 | 6,000 | 119,800 | May 07, 2014, 04:42 PM |
| Ryan Jason | Senior Vice President, Finance | Apr 16, 2014 | Option Exercise | $0.08 | 3,541 | 283 | 3,541 | Apr 18, 2014, 05:47 PM |
| Ryan Jason | Senior Vice President, Finance | Apr 16, 2014 | Sale | $26.36 | 3,541 | 93,335 | 0 | Apr 18, 2014, 05:47 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 16, 2014 | Sale | $26.86 | 30,000 | 805,728 | 120,000 | Apr 18, 2014, 05:42 PM |
| Miller Vincent A. | Chief Medical Officer | Apr 09, 2014 | Option Exercise | $29.94 | 12,500 | 374,250 | 150,000 | Apr 11, 2014, 05:45 PM |
| KRENITSKY KEVIN | Chief Commercial Officer & SVP | Apr 09, 2014 | Option Exercise | $29.94 | 3,250 | 97,305 | 140,750 | Apr 11, 2014, 05:31 PM |
| Kafka Steven J. | Chief Operating Officer | Apr 09, 2014 | Option Exercise | $29.94 | 5,000 | 149,700 | 5,000 | Apr 11, 2014, 05:28 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| ROCHE HOLDINGS INC | Director | 07/31/2018 | 2,222,280,699 |
| Yeshwant Krishna | Director | 07/31/2018 | 792,682 |
| Ryan Jason | Chief Financial Officer | 07/31/2018 | 5,783,455 |
| Ryan Jason | Chief Financial Officer | 07/31/2018 | 952,835 |
| Pellini Michael J | Director | 07/31/2018 | 14,208,407 |
| Nallicheri Melanie | Chief Business Officer | 07/31/2018 | 6,430,369 |
| Nallicheri Melanie | Chief Business Officer | 07/31/2018 | 2,613,138 |
| Miller Vincent A. | Chief Medical Officer | 07/31/2018 | 4,957,482 |
| Miller Vincent A. | Chief Medical Officer | 07/31/2018 | 4,246,041 |
| JONES EVAN/ FA | Director | 07/31/2018 | 1,274,100 |
| JONES EVAN/ FA | Director | 07/31/2018 | 2,418,324 |
| Hesslein Robert W. | SVP and General Counsel | 07/31/2018 | 3,933,133 |
| Hesslein Robert W. | SVP and General Counsel | 07/31/2018 | 10,479,678 |
| Fiedler Konstantin | Chief Operating Officer | 07/31/2018 | 3,230,734 |
| Fiedler Konstantin | Chief Operating Officer | 07/31/2018 | 445,661 |
| DOUGHERTY MICHAEL R | Director | 07/31/2018 | 1,735,653 |
| DOUGHERTY MICHAEL R | Director | 07/31/2018 | 1,660,440 |
| Doherty Michael J | Head of Product Development | 07/31/2018 | 8,950,484 |
| Doherty Michael J | Head of Product Development | 07/31/2018 | 2,185,835 |
| Cox Troy | President and CEO | 07/31/2018 | 28,338,039 |
| Cox Troy | President and CEO | 07/31/2018 | 4,825,277 |
| Civik Thomas | Chief Commercial Officer | 07/31/2018 | 4,578,677 |
| Borisy Alexis | Director | 07/31/2018 | 10,024,701 |
| Ryan Jason | Chief Financial Officer | 07/02/2018 | 465,054 |
| Nallicheri Melanie | Chief Business Officer | 07/02/2018 | 274,413 |
| Miller Vincent A. | Chief Medical Officer | 07/02/2018 | 397,544 |
| Hesslein Robert W. | SVP and General Counsel | 07/02/2018 | 344,383 |
| Fiedler Konstantin | Chief Operating Officer | 07/02/2018 | 135,840 |
| Doherty Michael J | Head of Product Development | 07/02/2018 | 365,566 |
| Cox Troy | Chief Executive Officer | 07/02/2018 | 191,597 |
| Pellini Michael J | Director | 06/15/2018 | 369,075 |
| Miller Vincent A. | Chief Medical Officer | 05/21/2018 | 47,006 |
| Miller Vincent A. | Chief Medical Officer | 05/21/2018 | 133,450 |
| Cox Troy | Chief Executive Officer | 05/16/2018 | 166,305 |
| Pellini Michael J | Director | 05/15/2018 | 266,175 |
| Cox Troy | Chief Executive Officer | 05/07/2018 | 494,481 |
| Ryan Jason | Chief Financial Officer | 04/16/2018 | 256,261 |
| Pellini Michael J | Director | 04/16/2018 | 261,275 |
| Miller Vincent A. | Chief Medical Officer | 04/16/2018 | 243,008 |
| Ryan Jason | Chief Financial Officer | 04/03/2018 | 72 |
| Doherty Michael J | Head of Product Development | 04/03/2018 | 145 |
| Pellini Michael J | Director | 04/03/2018 | 959,955 |
| Ryan Jason | Chief Financial Officer | 04/01/2018 | 1,018,395 |
| Ryan Jason | Chief Financial Officer | 04/02/2018 | 467,959 |
| Nallicheri Melanie | Chief Business Officer | 04/01/2018 | 905,231 |
| Nallicheri Melanie | Chief Business Officer | 04/02/2018 | 93,825 |
| Miller Vincent A. | Chief Medical Officer | 03/09/2018 | 203,921 |
| Miller Vincent A. | Chief Medical Officer | 03/09/2018 | 1,428,935 |
| Miller Vincent A. | Chief Medical Officer | 04/01/2018 | 1,018,395 |
| Miller Vincent A. | Chief Medical Officer | 04/02/2018 | 215,871 |
| Fiedler Konstantin | Chief Operating Officer | 04/01/2018 | 1,365,840 |
| Fiedler Konstantin | Chief Operating Officer | 04/02/2018 | 26,807 |
| Doherty Michael J | Head of Product Development | 04/01/2018 | 678,904 |
| Doherty Michael J | Head of Product Development | 04/02/2018 | 613,185 |
| Cox Troy | Chief Executive Officer | 04/01/2018 | 2,941,864 |
| Hesslein Robert W. | SVP and General Counsel | 04/01/2018 | 678,904 |
| Hesslein Robert W. | SVP and General Counsel | 04/02/2018 | 16,689 |
| Hesslein Robert W. | SVP and General Counsel | 04/02/2018 | 118,685 |
| Pellini Michael J | Director | 03/15/2018 | 274,015 |
| Ryan Jason | Chief Financial Officer | 03/15/2018 | 444,450 |
| Ryan Jason | Chief Financial Officer | 03/15/2018 | 1,173,900 |
| Miller Vincent A. | Chief Medical Officer | 02/20/2018 | 203,921 |
| Miller Vincent A. | Chief Medical Officer | 02/20/2018 | 1,428,935 |
| Miller Vincent A. | Chief Medical Officer | 02/20/2018 | 77,703 |
| Miller Vincent A. | Chief Medical Officer | 02/20/2018 | 2,460,455 |
| Ryan Jason | Chief Financial Officer | 02/15/2018 | 444,450 |
| Ryan Jason | Chief Financial Officer | 02/15/2018 | 1,012,950 |
| Pellini Michael J | Director | 02/15/2018 | 1,172,662 |
| Cox Troy | Chief Executive Officer | 02/15/2018 | 605,787 |
| Kafka Steven J. | President & COO | 02/13/2018 | 1,833,636 |
| Kafka Steven J. | President & COO | 02/07/2018 | 1,617,478 |
| Cox Troy | Chief Executive Officer | 02/07/2018 | 1,873,383 |
| Miller Vincent A. | Chief Medical Officer | 01/29/2018 | 18,304 |
| Miller Vincent A. | Chief Medical Officer | 01/29/2018 | 330,000 |
| Miller Vincent A. | Chief Medical Officer | 01/22/2018 | 14,437 |
| Miller Vincent A. | Chief Medical Officer | 01/22/2018 | 1,207,730 |
| Ryan Jason | Chief Financial Officer | 01/16/2018 | 592,600 |
| Ryan Jason | Chief Financial Officer | 01/16/2018 | 1,354,233 |
| Pellini Michael J | Director | 01/17/2018 | 665,028 |
| Pellini Michael J | Director | 01/16/2018 | 1,741,988 |
| Miller Vincent A. | Chief Medical Officer | 01/17/2018 | 4,649 |
| Miller Vincent A. | Chief Medical Officer | 01/16/2018 | 4,543 |
| Miller Vincent A. | Chief Medical Officer | 01/16/2018 | 601,762 |
| Miller Vincent A. | Chief Medical Officer | 01/17/2018 | 361,868 |
| Kafka Steven J. | President & COO | 01/16/2018 | 272,565 |
| Hesslein Robert W. | SVP and General Counsel | 01/16/2018 | 1,158,750 |
| Nallicheri Melanie | Chief Business Officer | 01/02/2018 | 95,616 |
| Miller Vincent A. | Chief Medical Officer | 12/07/2017 | 31,125 |
| Miller Vincent A. | Chief Medical Officer | 01/02/2018 | 150,336 |
| Kafka Steven J. | President & COO | 01/03/2018 | 144,448 |
| Kafka Steven J. | President & COO | 01/02/2018 | 10,048 |
| Hesslein Robert W. | SVP and General Counsel | 01/02/2018 | 119,296 |
| Civik Thomas | Chief Commercial Officer | 01/01/2018 | 2,279,312 |
| Ryan Jason | Chief Financial Officer | 01/02/2018 | 149,504 |
| Pellini Michael J | Director | 12/07/2017 | 155,625 |
| Pellini Michael J | Director | 12/13/2017 | 3,008,116 |
| JONES EVAN/ FA | Director | 12/13/2017 | 86,870 |
| Kafka Steven J. | President & COO | 12/07/2017 | 471,644 |
| Kafka Steven J. | President & COO | 12/07/2017 | 5,448,339 |
| Ryan Jason | Chief Financial Officer | 12/05/2017 | 133,302 |
| Ryan Jason | Chief Financial Officer | 12/05/2017 | 1,330,935 |
| Pellini Michael J | Director | 12/06/2017 | 1,217,230 |
| Pellini Michael J | Director | 12/05/2017 | 556,488 |
| Miller Vincent A. | Chief Medical Officer | 12/05/2017 | 1,223,400 |
| Kafka Steven J. | President & COO | 12/06/2017 | 24,020 |
| Kafka Steven J. | President & COO | 12/06/2017 | 338,183 |
| JONES EVAN/ FA | Director | 12/06/2017 | 34,728 |
| JONES EVAN/ FA | Director | 12/05/2017 | 359,546 |
| Ryan Jason | Chief Financial Officer | 11/02/2017 | 486,550 |
| Kafka Steven J. | President & COO | 10/13/2017 | 149,968 |
| Ryan Jason | Chief Financial Officer | 10/12/2017 | 51,898 |
| Ryan Jason | Chief Financial Officer | 10/02/2017 | 122,375 |
| Pellini Michael J | Director | 10/02/2017 | 168,741 |
| Nallicheri Melanie | Chief Business Officer | 10/02/2017 | 211,072 |
| Miller Vincent A. | Chief Medical Officer | 10/02/2017 | 114,227 |
| Kafka Steven J. | President & COO | 10/02/2017 | 124,199 |
| Hesslein Robert W. | SVP and General Counsel | 10/02/2017 | 84,002 |
| Yeshwant Krishna | Director | 08/08/2017 | 192,048 |
| Pellini Michael J | Director | 08/09/2017 | 137,025 |
| Pellini Michael J | Director | 08/09/2017 | 1,185,600 |
| Daly David | Chief Commercial Officer | 08/09/2017 | 1,042,433 |
| Daly David | Chief Commercial Officer | 08/09/2017 | 1,851,444 |
| Yeshwant Krishna | Director | 08/04/2017 | 324,084 |
| Yeshwant Krishna | Director | 08/04/2017 | 324,051 |
| Yeshwant Krishna | Director | 08/04/2017 | 665,953 |
| Ryan Jason | Chief Financial Officer | 07/13/2017 | 202,191 |
| Kafka Steven J. | President & COO | 07/14/2017 | 461,226 |
| Ryan Jason | Chief Financial Officer | 07/06/2017 | 259,568 |
| Pellini Michael J | Director | 07/06/2017 | 615,847 |
| Miller Vincent A. | Chief Medical Officer | 07/06/2017 | 210,047 |
| Kafka Steven J. | President & COO | 07/06/2017 | 287,338 |
| Kafka Steven J. | President & COO | 07/05/2017 | 479,844 |
| Hesslein Robert W. | SVP and General Counsel | 07/06/2017 | 196,919 |
| Daly David | Chief Commercial Officer | 07/06/2017 | 245,313 |
| Yeshwant Krishna | Director | 06/20/2017 | 231,729 |
| JONES EVAN/ FA | Director | 06/20/2017 | 231,729 |
| DOUGHERTY MICHAEL R | Director | 06/20/2017 | 231,729 |
| Borisy Alexis | Director | 06/20/2017 | 231,729 |
| Hesslein Robert W. | SVP and General Counsel | 06/08/2017 | 36,196 |
| Ryan Jason | Chief Financial Officer | 06/02/2017 | 222,920 |
| Daly David | Chief Commercial Officer | 06/01/2017 | 21,256 |
| Hesslein Robert W. | SVP and General Counsel | 05/12/2017 | 34,175 |
| Ryan Jason | Chief Financial Officer | 05/01/2017 | 1,171,877 |
| Miller Vincent A. | Chief Medical Officer | 05/01/2017 | 878,890 |
| Hesslein Robert W. | SVP and General Counsel | 05/01/2017 | 585,939 |
| Daly David | Chief Commercial Officer | 05/01/2017 | 878,890 |
| Ryan Jason | Chief Financial Officer | 04/18/2017 | 17,379 |
| Kafka Steven J. | President & COO | 04/18/2017 | 152,193 |
| Ryan Jason | Chief Financial Officer | 04/03/2017 | 39,407 |
| Pellini Michael J | Director | 04/03/2017 | 54,332 |
| Miller Vincent A. | Chief Medical Officer | 03/13/2017 | 32,700 |
| Miller Vincent A. | Chief Medical Officer | 04/03/2017 | 43,242 |
| Kafka Steven J. | President & COO | 04/03/2017 | 68,938 |
| Hesslein Robert W. | SVP and General Counsel | 04/03/2017 | 39,407 |
| Daly David | Chief Commercial Officer | 04/03/2017 | 66,157 |
| Ryan Jason | Chief Financial Officer | 03/16/2017 | 41,210 |
| Ryan Jason | Chief Financial Officer | 03/16/2017 | 396,000 |
| Hesslein Robert W. | SVP and General Counsel | 03/16/2017 | 197,336 |
| Pellini Michael J | Director | 03/08/2017 | 67,562 |
| Pellini Michael J | Director | 03/07/2017 | 217,238 |
| Pellini Michael J | Director | 03/08/2017 | 325,283 |
| Pellini Michael J | Director | 03/07/2017 | 1,046,832 |
| Kafka Steven J. | President & COO | 02/06/2017 | 1,000,017 |
| Kafka Steven J. | President & COO | 02/08/2017 | 242,045 |
| Cox Troy | Chief Executive Officer | 02/06/2017 | 4,750,017 |
| Ryan Jason | Chief Financial Officer | 01/13/2017 | 33,763 |
| Ryan Jason | Chief Financial Officer | 01/04/2017 | 26,367 |
| Ryan Jason | Chief Financial Officer | 01/03/2017 | 56,391 |
| Pellini Michael J | Chief Executive Officer | 01/04/2017 | 64,549 |
| Pellini Michael J | Chief Executive Officer | 01/03/2017 | 194,052 |
| Miller Vincent A. | Chief Medical Officer | 01/03/2017 | 61,039 |
| Miller Vincent A. | Chief Medical Officer | 01/04/2017 | 23,427 |
| Kafka Steven J. | President & COO | 01/04/2017 | 43,932 |
| Kafka Steven J. | President & COO | 01/03/2017 | 104,704 |
| Hesslein Robert W. | SVP and General Counsel | 01/04/2017 | 26,367 |
| Hesslein Robert W. | SVP and General Counsel | 01/03/2017 | 56,687 |
| Daly David | Chief Commercial Officer | 12/01/2016 | 11,252 |
| Kafka Steven J. | President & COO | 11/22/2016 | 20,026 |
| Kafka Steven J. | President & COO | 11/18/2016 | 6,069 |
| Kafka Steven J. | President & COO | 11/22/2016 | 110,722 |
| Kafka Steven J. | President & COO | 11/18/2016 | 33,645 |
| Kafka Steven J. | President & COO | 11/16/2016 | 4,160 |
| Kafka Steven J. | President & COO | 11/16/2016 | 23,000 |
| DOUGHERTY MICHAEL R | Director | 10/26/2016 | 447,521 |
| Ryan Jason | Chief Financial Officer | 10/20/2016 | 11,360 |
| Kafka Steven J. | President & COO | 10/20/2016 | 101,821 |
| Ryan Jason | Chief Financial Officer | 10/04/2016 | 28,853 |
| Pellini Michael J | Chief Executive Officer | 10/04/2016 | 62,176 |
| Miller Vincent A. | Chief Medical Officer | 09/13/2016 | 30,436 |
| Miller Vincent A. | Chief Medical Officer | 10/04/2016 | 25,637 |
| Miller Vincent A. | Chief Medical Officer | 10/03/2016 | 5,944 |
| Kafka Steven J. | President & COO | 10/04/2016 | 48,057 |
| Kafka Steven J. | President & COO | 10/03/2016 | 2,373 |
| Hesslein Robert W. | SVP and General Counsel | 10/04/2016 | 28,853 |
| Daly David | Chief Commercial Officer | 10/04/2016 | 48,364 |
| Kafka Steven J. | President & COO | 09/20/2016 | 32,656 |
| Kafka Steven J. | President & COO | 09/20/2016 | 224,415 |
| Daly David | Chief Commercial Officer | 09/01/2016 | 11,284 |
| Ryan Jason | Chief Financial Officer | 08/19/2016 | 35,600 |
| Ryan Jason | Chief Financial Officer | 08/19/2016 | 331,614 |
| Hesslein Robert W. | SVP and General Counsel | 08/09/2016 | 48,255 |
| Kafka Steven J. | President & COO | 08/05/2016 | 41,600 |
| Kafka Steven J. | President & COO | 08/05/2016 | 241,600 |
| Ryan Jason | Chief Financial Officer | 07/01/2016 | 59,422 |
| Ryan Jason | Chief Financial Officer | 07/05/2016 | 23,190 |
| Pellini Michael J | Chief Executive Officer | 07/05/2016 | 50,042 |
| Pellini Michael J | Chief Executive Officer | 07/01/2016 | 129,051 |
| Miller Vincent A. | Chief Medical Officer | 07/05/2016 | 20,616 |
| Miller Vincent A. | Chief Medical Officer | 07/01/2016 | 64,360 |
| Kafka Steven J. | President & COO | 07/01/2016 | 76,135 |
| Kafka Steven J. | President & COO | 07/05/2016 | 38,656 |
| Hesslein Robert W. | SVP and General Counsel | 07/05/2016 | 23,190 |
| Hesslein Robert W. | SVP and General Counsel | 07/01/2016 | 59,735 |
| Daly David | Chief Commercial Officer | 07/05/2016 | 38,894 |
| Daly David | Chief Commercial Officer | 07/01/2016 | 50,048 |
| Yeshwant Krishna | Director | 06/16/2016 | 240,655 |
| Schenkein David P | Director | 06/16/2016 | 240,655 |
| JONES EVAN/ FA | Director | 06/16/2016 | 240,655 |
| Borisy Alexis | Director | 06/16/2016 | 240,655 |
| Daly David | Chief Commercial Officer | 06/03/2016 | 10,224 |
| Ryan Jason | Chief Financial Officer | 04/01/2016 | 821,250 |
| Pellini Michael J | Chief Executive Officer | 04/01/2016 | 1,642,500 |
| Miller Vincent A. | Chief Medical Officer | 04/01/2016 | 730,000 |
| Kafka Steven J. | President & COO | 04/01/2016 | 1,368,750 |
| Hesslein Robert W. | SVP and General Counsel | 04/01/2016 | 821,250 |
| Daly David | Chief Commercial Officer | 04/01/2016 | 1,277,500 |
| Miller Vincent A. | Chief Medical Officer | 04/01/2016 | 6,436 |
| Kafka Steven J. | President & COO | 04/01/2016 | 2,242 |
| Daly David | Chief Commercial Officer | 03/01/2016 | 10,613 |
| Miller Vincent A. | Chief Medical Officer | 01/04/2016 | 6,521 |
| Kafka Steven J. | President & COO | 01/04/2016 | 2,227 |
| Pellini Michael J | Chief Executive Officer | 12/15/2015 | 1,502,154 |
| Daly David | Chief Commercial Officer | 12/01/2015 | 42,946 |
| Pellini Michael J | Chief Executive Officer | 11/13/2015 | 149,555 |
| Miller Vincent A. | Chief Medical Officer | 10/01/2015 | 5,722 |
| Kafka Steven J. | President & COO | 10/01/2015 | 1,956 |
| Ryan Jason | Chief Financial Officer | 07/15/2015 | 972,313 |
| Pellini Michael J | Chief Executive Officer | 07/15/2015 | 1,943,610 |
| Miller Vincent A. | Chief Medical Officer | 07/15/2015 | 974,735 |
| Kafka Steven J. | President & COO | 07/15/2015 | 1,214,752 |
| Hesslein Robert W. | SVP and General Counsel | 07/15/2015 | 977,420 |
| Daly David | Chief Commercial Officer | 07/15/2015 | 759,241 |
| Hesslein Robert W. | SVP and General Counsel | 07/08/2015 | 24,124 |
| Miller Vincent A. | Chief Medical Officer | 07/01/2015 | 10,577 |
| Kafka Steven J. | President & COO | 07/01/2015 | 3,627 |
| Yeshwant Krishna | Director | 06/18/2015 | 193,283 |
| Schenkein David P | Director | 06/18/2015 | 193,283 |
| JONES EVAN/ FA | Director | 06/18/2015 | 193,283 |
| Borisy Alexis | Director | 06/18/2015 | 193,283 |
| Google Ventures 2011 GP, L.L.C. | 10% Owner | 06/15/2015 | 3,701,171 |
| Google Ventures 2011 GP, L.L.C. | 10% Owner | 06/12/2015 | 1,808,909 |
| Google Ventures 2011 GP, L.L.C. | 10% Owner | 06/11/2015 | 552,893 |
| Yeshwant Krishna | Director | 06/15/2015 | 3,701,171 |
| Yeshwant Krishna | Director | 06/12/2015 | 1,808,909 |
| Yeshwant Krishna | Director | 06/11/2015 | 552,893 |
| Yeshwant Krishna | Director | 05/14/2015 | 331,702 |
| Google Ventures 2011 GP, L.L.C. | 10% Owner | 05/14/2015 | 331,702 |
| Pellini Michael J | Chief Executive Officer | 05/12/2015 | 704,231 |
| Yeshwant Krishna | Director | 04/07/2015 | 47,609,600 |
| Borisy Alexis | Director | 04/07/2015 | 12,088,400 |
| THIRD ROCK VENTURES LP | 10% Owner | 04/07/2015 | 204,938,900 |
| Schenkein David P | Director | 04/07/2015 | 1,299,800 |
| Schenkein David P | Director | 04/07/2015 | 1,299,800 |
| Schenkein David P | Director | 04/07/2015 | 1,299,800 |
| Pellini Michael J | Chief Executive Officer | 04/07/2015 | 19,735,000 |
| Miller Vincent A. | Chief Medical Officer | 04/07/2015 | 3,222,000 |
| BYERS BROOK H | Director | 04/07/2015 | 40,800 |
| BYERS BROOK H | Director | 04/07/2015 | 621,050 |
| BYERS BROOK H | Director | 04/07/2015 | 117,409,700 |
| BYERS BROOK H | Director | 04/07/2015 | 40,800 |
| Kleiner Perkins Caufield & Byers XIV, LLC | 10% Owner | 04/07/2015 | 117,409,700 |
| JONES EVAN/ FA | Director | 04/07/2015 | 2,300,450 |
| JONES EVAN/ FA | Director | 04/07/2015 | 419,100 |
| Hesslein Robert W. | SVP and General Counsel | 04/07/2015 | 1,795,000 |
| Yeshwant Krishna | Director | 04/07/2015 | 46,186,750 |
| Schenkein David P | Director | 04/07/2015 | 1,260,900 |
| Schenkein David P | Director | 04/07/2015 | 1,260,900 |
| Schenkein David P | Director | 04/07/2015 | 1,260,900 |
| Kleiner Perkins Caufield & Byers XIV, LLC | 10% Owner | 04/07/2015 | 113,900,600 |
| BYERS BROOK H | Director | 04/07/2015 | 39,550 |
| BYERS BROOK H | Director | 04/07/2015 | 602,450 |
| BYERS BROOK H | Director | 04/07/2015 | 113,900,600 |
| BYERS BROOK H | Director | 04/07/2015 | 39,550 |
| JONES EVAN/ FA | Director | 04/07/2015 | 2,231,700 |
| JONES EVAN/ FA | Director | 04/07/2015 | 406,550 |
| Hesslein Robert W. | SVP and General Counsel | 04/07/2015 | 1,751,000 |
| Miller Vincent A. | Chief Medical Officer | 04/07/2015 | 3,125,700 |
| Pellini Michael J | Chief Executive Officer | 04/07/2015 | 19,145,150 |
| Borisy Alexis | Director | 04/07/2015 | 11,727,100 |
| THIRD ROCK VENTURES LP | 10% Owner | 04/07/2015 | 198,813,900 |
| ROCHE HOLDINGS INC | Director | 04/07/2015 | 250,000,000 |
| ROCHE HOLDINGS INC | Director | 04/07/2015 | 780,214,400 |
| Miller Vincent A. | Chief Medical Officer | 04/01/2015 | 17,060 |
| Kafka Steven J. | President & COO | 04/01/2015 | 5,127 |
| Pellini Michael J | Chief Executive Officer | 03/30/2015 | 848,323 |
| JONES EVAN/ FA | Director | 03/16/2015 | 53,247 |
| Hesslein Robert W. | SVP and General Counsel | 03/05/2015 | 218,957 |
| Pellini Michael J | President & CEO | 03/04/2015 | 99,553 |
| Pellini Michael J | President & CEO | 03/05/2015 | 390,488 |
| Pellini Michael J | President & CEO | 03/04/2015 | 3,154,394 |
| Pellini Michael J | President & CEO | 03/05/2015 | 4,086,807 |
| Miller Vincent A. | Chief Medical Officer | 03/03/2015 | 133,663 |
| Miller Vincent A. | Chief Medical Officer | 03/03/2015 | 815,616 |
| Kafka Steven J. | Chief Operating Officer | 03/03/2015 | 165,454 |
| Kafka Steven J. | Chief Operating Officer | 03/03/2015 | 1,578,397 |
| Hesslein Robert W. | SVP and General Counsel | 03/02/2015 | 67,735 |
| Hesslein Robert W. | SVP and General Counsel | 03/02/2015 | 68,850 |
| Ryan Jason | Senior Vice President, Finance | 02/27/2015 | 84,430 |
| Ryan Jason | Senior Vice President, Finance | 02/27/2015 | 1,190,265 |
| Pellini Michael J | President & CEO | 02/11/2015 | 849,852 |
| Ryan Jason | Senior Vice President, Finance | 06/05/2014 | 382 |
| Ryan Jason | Senior Vice President, Finance | 06/05/2014 | 115,498 |
| Kafka Steven J. | Chief Operating Officer | 01/15/2015 | 92,000 |
| Kafka Steven J. | Chief Operating Officer | 01/15/2015 | 725,673 |
| Pellini Michael J | President & CEO | 01/12/2015 | 1,149,147 |
| Miller Vincent A. | Chief Medical Officer | 01/12/2015 | 106,055 |
| Kafka Steven J. | Chief Operating Officer | 01/12/2015 | 56,960 |
| Kafka Steven J. | Chief Operating Officer | 01/12/2015 | 414,623 |
| Hesslein Robert W. | SVP and General Counsel | 01/12/2015 | 364,781 |
| Hesslein Robert W. | SVP and General Counsel | 01/08/2015 | 92,132 |
| Miller Vincent A. | Chief Medical Officer | 01/02/2015 | 6,987 |
| Kafka Steven J. | Chief Operating Officer | 01/02/2015 | 2,381 |
| Pellini Michael J | President & CEO | 12/29/2014 | 298,919 |
| Ryan Jason | Senior Vice President, Finance | 12/15/2014 | 189 |
| Ryan Jason | Senior Vice President, Finance | 12/15/2014 | 50,880 |
| Daly David | Chief Commercial Officer | 12/05/2014 | 556,000 |
| Ryan Jason | Senior Vice President, Finance | 11/17/2014 | 283 |
| Ryan Jason | Senior Vice President, Finance | 11/17/2014 | 88,185 |
| Pellini Michael J | President & CEO | 11/14/2014 | 74,519 |
| Pellini Michael J | President & CEO | 11/13/2014 | 236,850 |
| Kafka Steven J. | Chief Operating Officer | 10/27/2014 | 41,600 |
| Kafka Steven J. | Chief Operating Officer | 10/27/2014 | 253,127 |
| Ryan Jason | Senior Vice President, Finance | 10/27/2014 | 189 |
| Ryan Jason | Senior Vice President, Finance | 10/27/2014 | 59,000 |
| Pellini Michael J | President & CEO | 10/17/2014 | 287,500 |
| Hesslein Robert W. | SVP and General Counsel | 10/17/2014 | 92,733 |
| Ryan Jason | Senior Vice President, Finance | 10/15/2014 | 189 |
| Ryan Jason | Senior Vice President, Finance | 10/15/2014 | 47,432 |
| Miller Vincent A. | Chief Medical Officer | 10/01/2014 | 5,888 |
| KRENITSKY KEVIN | Chief Commercial Officer & SVP | 10/01/2014 | 1,313 |
| Kafka Steven J. | Chief Operating Officer | 10/01/2014 | 2,006 |
| Ryan Jason | Senior Vice President, Finance | 09/15/2014 | 189 |
| Ryan Jason | Senior Vice President, Finance | 09/15/2014 | 51,750 |
| Ryan Jason | Senior Vice President, Finance | 08/15/2014 | 283 |
| Ryan Jason | Senior Vice President, Finance | 08/15/2014 | 88,982 |
| Pellini Michael J | President & CEO | 08/18/2014 | 200,798 |
| Pellini Michael J | President & CEO | 08/15/2014 | 115,266 |
| Kafka Steven J. | Chief Operating Officer | 07/22/2014 | 41,600 |
| Kafka Steven J. | Chief Operating Officer | 07/22/2014 | 271,445 |
| Ryan Jason | Senior Vice President, Finance | 07/15/2014 | 283 |
| Ryan Jason | Senior Vice President, Finance | 07/15/2014 | 96,387 |
| Miller Vincent A. | Chief Medical Officer | 07/15/2014 | 408,746 |
| Hesslein Robert W. | SVP and General Counsel | 07/08/2014 | 108,895 |
| Pellini Michael J | President & CEO | 07/02/2014 | 70,000 |
| Pellini Michael J | President & CEO | 07/01/2014 | 341,244 |
| Miller Vincent A. | Chief Medical Officer | 07/01/2014 | 8,432 |
| KRENITSKY KEVIN | Chief Commercial Officer & SVP | 07/01/2014 | 1,877 |
| Kafka Steven J. | Chief Operating Officer | 07/01/2014 | 2,883 |
| Ryan Jason | Senior Vice President, Finance | 06/26/2014 | 94 |
| Ryan Jason | Senior Vice President, Finance | 06/26/2014 | 29,500 |
| Kafka Steven J. | Chief Operating Officer | 06/26/2014 | 20,800 |
| Kafka Steven J. | Chief Operating Officer | 06/26/2014 | 125,936 |
| Kafka Steven J. | Chief Operating Officer | 06/19/2014 | 20,800 |
| Kafka Steven J. | Chief Operating Officer | 06/19/2014 | 122,304 |
| Ryan Jason | Senior Vice President, Finance | 06/16/2014 | 189 |
| Ryan Jason | Senior Vice President, Finance | 06/16/2014 | 53,391 |
| Yeshwant Krishna | Director | 06/13/2014 | 29,120,000 |
| Ryan Jason | Senior Vice President, Finance | 06/09/2014 | 94 |
| Ryan Jason | Senior Vice President, Finance | 06/09/2014 | 29,500 |
| Pellini Michael J | President & CEO | 06/04/2014 | 588,155 |
| Kafka Steven J. | Chief Operating Officer | 06/05/2014 | 18,720 |
| Kafka Steven J. | Chief Operating Officer | 06/05/2014 | 108,838 |
| Ryan Jason | Senior Vice President, Finance | 06/05/2014 | 800 |
| Ryan Jason | Senior Vice President, Finance | 06/05/2014 | 240,594 |
| Miller Vincent A. | Chief Medical Officer | 04/09/2014 | 374,250 |
| KRENITSKY KEVIN | Chief Commercial Officer & SVP | 04/09/2014 | 97,305 |
| Kafka Steven J. | Chief Operating Officer | 04/09/2014 | 149,700 |
| Ryan Jason | Senior Vice President, Finance | 05/15/2014 | 189 |
| Ryan Jason | Senior Vice President, Finance | 05/15/2014 | 49,452 |
| Miller Vincent A. | Chief Medical Officer | 05/06/2014 | 84,000 |
| Miller Vincent A. | Chief Medical Officer | 05/05/2014 | 6,000 |
| Ryan Jason | Senior Vice President, Finance | 04/16/2014 | 283 |
| Ryan Jason | Senior Vice President, Finance | 04/16/2014 | 93,335 |
| Miller Vincent A. | Chief Medical Officer | 04/16/2014 | 805,728 |
| Miller Vincent A. | Chief Medical Officer | 04/09/2014 | 374,250 |
| KRENITSKY KEVIN | Chief Commercial Officer & SVP | 04/09/2014 | 97,305 |
| Kafka Steven J. | Chief Operating Officer | 04/09/2014 | 149,700 |
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