Sangamo Therapeutics Inc. (SGMO) NASDAQ
$0.51 0.03 (5.44%)
Market Cap: $91.51M
As of 04/19/24 04:00 PM EDT. Market closed.
Sangamo Therapeutics Inc. (SGMO)
NASDAQ
$0.51
0.03 (5.44%)
Market Cap: $91.51M
As of 04/19/24 04:00 PM EDT. Market closed.
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for sangamo therapeutics, science is a means to develop new medicines with the potential to transform the lives of patients living with serious genetic diseases. our scientists are leaders in the discovery, research and development of technologies enabling gene-based therapeutic development. currently we are conducting clinical trials, including the first ever in vivo human genome editing ... read more
for sangamo therapeutics, science is a means to develop new medicines with the potential to transform the lives of patients living with serious genetic diseases. our scientists are leaders in the discovery, research and development of technologies enabling gene-based therapeutic development. currently we are conducting clinical trials, including the first ever in vivo human genome editing studies. to learn more about sangamo, visit the our website at www.sangamo.com. read less
COMPANY PROFILE
Sector
Professional, Scientific, and Technical Services
Industry
Research and Development in Biotechnology (except Nanobiotechnology)
CEO
Alexander Macrae
Full Time Employees
520
Sector
Professional, Scientific, and Technical Services
Industry
Research and Development in Biotechnology (except Nanobiotechnology)
CEO
Alexander Macrae
Full Time Employees
520
CEO Compensation (Base)
$636,480
URL
Address
7000 Marina Blvd, California, Brisbane, 94005.
PRICE CHART FOR SANGAMO THERAPEUTICS INC
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
$0.48
Previous Close
$0.49
Days Range
$0.47 - $0.53
52 week range
$0.29 - $1.78
Volume
1,050,146
Avg. Volume (30 days)
1,974,805
Market Cap
$91.51M
Dividend Yield
-
P/E
(0.35)
Shares Outstanding
178,906,350
Open
$0.48
Previous Close
$0.49
Days Range
$0.47 - $0.53
52 week range
$0.29 - $1.78
Volume
1,050,146
Avg. Volume (30 days)
1,974,805
Market Cap
$91.51M
Dividend Yield
-
P/E
(0.35)
Shares Outstanding
178,906,350
FINANCIAL STATEMENTS FOR SANGAMO THERAPEUTICS INC
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INSIDER TRANSACTIONS FOR SANGAMO THERAPEUTICS INC
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Pooler Amy | VP, HEAD OF RESEARCH | Feb 25, 2024 | Option Exercise | $1.13 | 2,459 | 2,779 | 196,314 | Feb 27, 2024, 05:14 PM |
| Pooler Amy | VP, HEAD OF RESEARCH | Feb 24, 2024 | Option Exercise | $1.13 | 2,209 | 2,496 | 198,773 | Feb 27, 2024, 05:14 PM |
| Willoughby Scott B. | SVP, GEN. COUNSEL & SECRETARY | Feb 25, 2024 | Option Exercise | $1.13 | 3,453 | 3,902 | 836,430 | Feb 27, 2024, 05:13 PM |
| Willoughby Scott B. | SVP, GEN. COUNSEL & SECRETARY | Feb 24, 2024 | Option Exercise | $1.13 | 4,379 | 4,948 | 839,883 | Feb 27, 2024, 05:13 PM |
| Dubois-Stringfellow Nathalie | SVP-CHIEF DEVELOPMENT OFFICER | Feb 25, 2024 | Option Exercise | $1.13 | 5,010 | 5,661 | 846,188 | Feb 27, 2024, 05:13 PM |
| Dubois-Stringfellow Nathalie | SVP-CHIEF DEVELOPMENT OFFICER | Feb 24, 2024 | Option Exercise | $1.13 | 5,474 | 6,186 | 851,198 | Feb 27, 2024, 05:13 PM |
| Duraibabu Prathyusha | SVP, CHIEF FINANCIAL OFFICER | Feb 25, 2024 | Option Exercise | $1.13 | 3,453 | 3,902 | 834,578 | Feb 27, 2024, 05:12 PM |
| Duraibabu Prathyusha | SVP, CHIEF FINANCIAL OFFICER | Feb 24, 2024 | Option Exercise | $1.13 | 5,474 | 6,186 | 838,031 | Feb 27, 2024, 05:12 PM |
| Macrae Sandy | PRESIDENT, CEO AND DIRECTOR | Feb 25, 2024 | Option Exercise | $1.13 | 24,157 | 27,297 | 2,552,204 | Feb 27, 2024, 05:11 PM |
| Macrae Sandy | PRESIDENT, CEO AND DIRECTOR | Feb 24, 2024 | Option Exercise | $1.13 | 16,115 | 18,210 | 2,576,361 | Feb 27, 2024, 05:11 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Nov 25, 2023 | Option Exercise | $0.38 | 1,329 | 508 | 126,762 | Nov 28, 2023, 04:20 PM |
| McClung David Mark | EVP, Chief Operating Officer | Nov 25, 2023 | Option Exercise | $0.38 | 1,925 | 736 | 212,471 | Nov 28, 2023, 04:19 PM |
| Macrae Sandy | President, CEO and Director | Nov 25, 2023 | Option Exercise | $0.38 | 10,411 | 3,978 | 592,476 | Nov 28, 2023, 04:19 PM |
| Fontenot Jason D. | SVP, Chief Scientific Officer | Nov 25, 2023 | Option Exercise | $0.38 | 1,030 | 394 | 136,270 | Nov 28, 2023, 04:18 PM |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | Nov 25, 2023 | Option Exercise | $0.38 | 1,329 | 508 | 131,005 | Nov 28, 2023, 04:17 PM |
| Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | Nov 25, 2023 | Option Exercise | $0.38 | 1,462 | 559 | 139,172 | Nov 28, 2023, 04:16 PM |
| Pooler Amy | VP, Head of Research | Nov 25, 2023 | Option Exercise | $0.38 | 490 | 187 | 50,982 | Nov 28, 2023, 04:15 PM |
| BIOGEN INC. | 10% Owner | Sep 26, 2023 | Sale | $0.50 | 6,000,000 | 3,000,000 | 17,652,466 | Sep 28, 2023, 05:30 PM |
| Fontenot Jason D. | SVP, Chief Scientific Officer | Aug 25, 2023 | Option Exercise | $0.77 | 1,029 | 792 | 137,300 | Aug 29, 2023, 04:15 PM |
| McClung David Mark | EVP, Chief Operating Officer | Aug 25, 2023 | Option Exercise | $0.77 | 1,925 | 1,482 | 214,396 | Aug 29, 2023, 04:15 PM |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | Aug 25, 2023 | Option Exercise | $0.77 | 1,329 | 1,023 | 132,334 | Aug 29, 2023, 04:14 PM |
| Macrae Sandy | President, CEO and Director | Aug 25, 2023 | Option Exercise | $0.77 | 10,411 | 8,016 | 602,887 | Aug 29, 2023, 04:13 PM |
| Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | Aug 25, 2023 | Option Exercise | $0.77 | 1,462 | 1,126 | 140,634 | Aug 29, 2023, 04:13 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Aug 25, 2023 | Option Exercise | $0.77 | 1,329 | 1,023 | 128,091 | Aug 29, 2023, 04:12 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Aug 13, 2023 | Option Exercise | $1.08 | 864 | 933 | 129,420 | Aug 15, 2023, 04:55 PM |
| McClung David Mark | EVP, Chief Operating Officer | Jun 25, 2023 | Option Exercise | $1.19 | 11,528 | 13,718 | 211,321 | Jun 26, 2023, 04:31 PM |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | Jun 11, 2023 | Option Exercise | $1.19 | 864 | 1,028 | 133,663 | Jun 13, 2023, 04:55 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | May 25, 2023 | Option Exercise | $1.33 | 1,328 | 1,766 | 125,284 | May 30, 2023, 04:45 PM |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | May 25, 2023 | Option Exercise | $1.33 | 1,750 | 2,328 | 171,467 | May 30, 2023, 04:44 PM |
| McClung David Mark | EVP, Chief Operating Officer | May 25, 2023 | Option Exercise | $1.33 | 1,925 | 2,560 | 222,849 | May 30, 2023, 04:43 PM |
| Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | May 25, 2023 | Option Exercise | $1.33 | 1,462 | 1,944 | 137,096 | May 30, 2023, 04:43 PM |
| Fontenot Jason D. | SVP, Chief Scientific Officer | May 25, 2023 | Option Exercise | $1.33 | 1,029 | 1,369 | 138,329 | May 30, 2023, 04:42 PM |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | May 25, 2023 | Option Exercise | $1.33 | 1,328 | 1,766 | 132,052 | May 30, 2023, 04:41 PM |
| Macrae Sandy | President, CEO and Director | May 25, 2023 | Option Exercise | $1.33 | 10,411 | 13,847 | 613,298 | May 30, 2023, 04:40 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Apr 24, 2023 | Option Exercise | $1.65 | 3,977 | 6,562 | 126,612 | Apr 26, 2023, 05:22 PM |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | Mar 25, 2023 | Option Exercise | $1.66 | 345 | 573 | 133,380 | Mar 28, 2023, 05:04 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Feb 25, 2023 | Option Exercise | $2.66 | 5,128 | 13,640 | 130,589 | Mar 06, 2023, 05:10 PM |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | Feb 25, 2023 | Option Exercise | $2.66 | 15,618 | 41,544 | 173,217 | Mar 06, 2023, 05:09 PM |
| McClung David Mark | EVP, Chief Operating Officer | Feb 25, 2023 | Option Exercise | $2.66 | 9,745 | 25,922 | 224,774 | Mar 06, 2023, 05:09 PM |
| Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | Feb 25, 2023 | Option Exercise | $2.66 | 9,834 | 26,158 | 138,558 | Mar 06, 2023, 05:08 PM |
| Fontenot Jason D. | SVP, Chief Scientific Officer | Feb 25, 2023 | Option Exercise | $2.66 | 6,559 | 17,447 | 139,358 | Mar 06, 2023, 05:07 PM |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | Feb 25, 2023 | Option Exercise | $2.66 | 7,030 | 18,700 | 133,725 | Mar 06, 2023, 05:07 PM |
| Macrae Sandy | President, CEO and Director | Feb 25, 2023 | Option Exercise | $2.66 | 54,767 | 145,680 | 623,709 | Mar 06, 2023, 05:06 PM |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | Jun 11, 2022 | Option Exercise | $3.76 | 864 | 3,249 | 86,595 | Feb 06, 2023, 06:28 PM |
| BIOGEN INC. | 10% Owner | Aug 30, 2022 | Sale | $5.27 | 100,000 | 526,520 | 23,652,466 | Aug 31, 2022, 07:03 PM |
| BIOGEN INC. | 10% Owner | Aug 29, 2022 | Sale | $5.33 | 400,000 | 2,130,720 | 23,752,466 | Aug 31, 2022, 07:03 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Aug 13, 2022 | Option Exercise | $6.33 | 864 | 5,469 | 92,966 | Aug 16, 2022, 05:58 PM |
| McClung David Mark | EVP, Chief Operating Officer | Jun 25, 2022 | Option Exercise | $4.31 | 11,525 | 49,673 | 175,816 | Jun 28, 2022, 05:25 PM |
| Duraibabu Prathyusha | Vice President, Finance | Jun 11, 2022 | Option Exercise | $3.76 | 842 | 3,166 | 86,617 | Jun 14, 2022, 04:37 PM |
| Markels John | Director | Jun 03, 2022 | Buy | $3.69 | 6,784 | 25,029 | 32,484 | Jun 06, 2022, 04:41 PM |
| PARKER H STEWART | Director | Jun 01, 2022 | Buy | $3.60 | 5,000 | 17,996 | 48,700 | Jun 03, 2022, 04:18 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Apr 29, 2022 | Option Exercise | $4.15 | 140 | 581 | 90,709 | May 03, 2022, 05:09 PM |
| Fontenot Jason D. | SVP, Chief Scientific Officer | Apr 25, 2022 | Option Exercise | $4.83 | 826 | 3,990 | 103,167 | Apr 27, 2022, 05:09 PM |
| Duraibabu Prathyusha | Vice President, Finance | Apr 25, 2022 | Option Exercise | $4.83 | 662 | 3,197 | 86,772 | Apr 27, 2022, 05:08 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Apr 24, 2022 | Option Exercise | $4.70 | 3,976 | 18,687 | 90,849 | Apr 26, 2022, 05:37 PM |
| Duraibabu Prathyusha | Vice President, Finance | Mar 25, 2022 | Option Exercise | $5.75 | 345 | 1,984 | 87,434 | Mar 29, 2022, 04:41 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Feb 25, 2022 | Option Exercise | $5.90 | 1,566 | 9,239 | 53,825 | Mar 01, 2022, 05:21 PM |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | Feb 25, 2022 | Option Exercise | $5.90 | 12,388 | 73,089 | 88,429 | Mar 01, 2022, 05:19 PM |
| Fontenot Jason D. | SVP, Chief Scientific Officer | Feb 25, 2022 | Option Exercise | $5.90 | 6,248 | 36,863 | 58,893 | Mar 01, 2022, 05:18 PM |
| Duraibabu Prathyusha | Vice President, Finance | Feb 25, 2022 | Option Exercise | $5.90 | 3,474 | 20,497 | 46,779 | Mar 01, 2022, 05:18 PM |
| McClung David Mark | EVP, Chief Operating Officer | Feb 25, 2022 | Option Exercise | $5.90 | 4,610 | 27,199 | 125,584 | Mar 01, 2022, 05:17 PM |
| Macrae Sandy | President, CEO and Director | Feb 25, 2022 | Option Exercise | $5.90 | 49,890 | 294,351 | 297,176 | Mar 01, 2022, 05:16 PM |
| Schott Robert J. | SVP, Head of Development | Feb 12, 2022 | Option Exercise | $5.76 | 5,463 | 31,467 | 34,537 | Feb 24, 2022, 05:32 PM |
| BIOGEN INC. | 10% Owner | Dec 28, 2021 | Sale | $8.51 | 2,764 | 23,522 | 24,152,466 | Dec 30, 2021, 05:12 PM |
| BIOGEN INC. | 10% Owner | Dec 27, 2021 | Sale | $8.56 | 600 | 5,136 | 24,155,230 | Dec 28, 2021, 08:11 AM |
| BIOGEN INC. | 10% Owner | Dec 23, 2021 | Sale | $8.55 | 81,187 | 694,530 | 24,155,830 | Dec 28, 2021, 08:11 AM |
| BIOGEN INC. | 10% Owner | Dec 09, 2021 | Sale | $8.56 | 23,660 | 202,541 | 24,237,017 | Dec 10, 2021, 04:08 PM |
| BIOGEN INC. | 10% Owner | Dec 08, 2021 | Sale | $8.64 | 75,814 | 654,828 | 24,260,677 | Dec 09, 2021, 04:08 PM |
| BIOGEN INC. | 10% Owner | Dec 07, 2021 | Sale | $8.52 | 52,178 | 444,437 | 24,336,491 | Dec 09, 2021, 04:08 PM |
| BIOGEN INC. | 10% Owner | Dec 02, 2021 | Sale | $8.51 | 1,874 | 15,943 | 24,388,669 | Dec 03, 2021, 04:09 PM |
| BIOGEN INC. | 10% Owner | Dec 01, 2021 | Sale | $8.52 | 730 | 6,223 | 24,390,543 | Dec 03, 2021, 04:09 PM |
| BIOGEN INC. | 10% Owner | Nov 26, 2021 | Sale | $8.60 | 28,884 | 248,434 | 24,391,273 | Nov 30, 2021, 04:20 PM |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | Oct 29, 2021 | Option Exercise | $8.12 | 140 | 1,137 | 54,455 | Nov 03, 2021, 03:30 PM |
| McClung David Mark | EVP, Chief Business Officer | Jun 25, 2021 | Option Exercise | $12.02 | 11,525 | 138,531 | 129,294 | Jun 29, 2021, 07:55 PM |
| Fontenot Jason D. | SVP, Chief Scientific Officer | Apr 25, 2021 | Option Exercise | $11.71 | 811 | 9,497 | 62,496 | Apr 27, 2021, 08:49 PM |
| Duraibabu Prathyusha | VP, PFO and PAO | Apr 25, 2021 | Option Exercise | $11.71 | 662 | 7,752 | 40,128 | Apr 27, 2021, 08:49 PM |
| Duraibabu Prathyusha | VP, PFO and PAO | Mar 25, 2021 | Option Exercise | $12.27 | 345 | 4,233 | 40,790 | Mar 29, 2021, 07:11 PM |
| LOEB GARY | EVP, General Counsel & Sec. | Mar 23, 2021 | Option Exercise | $11.02 | 11,981 | 132,031 | 100,762 | Mar 25, 2021, 07:19 PM |
| LOEB GARY | EVP, General Counsel & Sec. | Mar 23, 2021 | Sale | $13.13 | 17,524 | 230,042 | 88,781 | Mar 25, 2021, 07:19 PM |
| Duraibabu Prathyusha | VP Principal Acct. Officer | Feb 25, 2021 | Option Exercise | $11.19 | 1,863 | 20,847 | 27,385 | Mar 01, 2021, 09:12 PM |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | Feb 25, 2021 | Option Exercise | $11.19 | 7,779 | 87,047 | 58,199 | Mar 01, 2021, 09:11 PM |
| LOEB GARY | EVP, General Counsel & Sec. | Feb 25, 2021 | Option Exercise | $11.19 | 5,762 | 64,477 | 44,781 | Mar 01, 2021, 09:09 PM |
| Macrae Sandy | President and CEO | Feb 25, 2021 | Option Exercise | $11.19 | 35,311 | 395,130 | 208,691 | Mar 01, 2021, 09:08 PM |
| Macrae Sandy | President and CEO | Jan 24, 2021 | Option Exercise | $14.95 | 3,977 | 59,456 | 244,002 | Jan 26, 2021, 08:24 PM |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | Dec 31, 2020 | Sale | $16.74 | 2,464 | 41,247 | 65,978 | Jan 06, 2021, 04:27 PM |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | Dec 24, 2020 | Sale | $18.13 | 3,331 | 60,391 | 68,442 | Dec 30, 2020, 07:51 PM |
| Ramasastry Saira | Director | Dec 17, 2020 | Option Exercise | $5.99 | 10,000 | 59,900 | 25,000 | Dec 18, 2020, 07:18 PM |
| Ramasastry Saira | Director | Dec 17, 2020 | Sale | $13.27 | 10,000 | 132,747 | 15,000 | Dec 18, 2020, 07:18 PM |
| Lee Sung | EVP, Chief Financial Officer | Nov 25, 2020 | Option Exercise | $9.77 | 5,042 | 49,260 | 88,708 | Nov 30, 2020, 07:46 PM |
| Boissel Stephane | EVP, Corp. Strategy | Jun 04, 2020 | Option Exercise | $11.23 | 14,907 | 167,406 | 70,116 | Jun 05, 2020, 09:29 PM |
| Duraibabu Prathyusha | VP Principal Acct. Officer | Apr 25, 2020 | Option Exercise | $8.32 | 647 | 5,383 | 26,603 | Apr 28, 2020, 06:59 PM |
| DILLY STEPHEN GEORGE | Director | Mar 19, 2020 | Option Exercise | $5.42 | 35,000 | 189,700 | 40,000 | Mar 20, 2020, 05:00 PM |
| DILLY STEPHEN GEORGE | Director | Mar 19, 2020 | Sale | $6.00 | 35,000 | 210,000 | 5,000 | Mar 20, 2020, 05:00 PM |
| PARKER H STEWART | Director | Mar 18, 2020 | Buy | $5.20 | 3,000 | 15,585 | 13,000 | Mar 19, 2020, 07:55 PM |
| Zakrzewski Joseph S | Director | Mar 17, 2020 | Buy | $4.99 | 5,000 | 24,950 | 30,000 | Mar 19, 2020, 05:00 PM |
| DILLY STEPHEN GEORGE | Director | Mar 16, 2020 | Option Exercise | $5.42 | 15,000 | 81,300 | 20,000 | Mar 18, 2020, 09:09 PM |
| DILLY STEPHEN GEORGE | Director | Mar 16, 2020 | Sale | $6.02 | 15,000 | 90,261 | 5,000 | Mar 18, 2020, 09:09 PM |
| Zakrzewski Joseph S | Director | Mar 13, 2020 | Buy | $5.67 | 5,000 | 28,350 | 25,000 | Mar 13, 2020, 05:41 PM |
| Zakrzewski Joseph S | Director | Mar 12, 2020 | Buy | $6.31 | 15,000 | 94,650 | 20,000 | Mar 13, 2020, 05:41 PM |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | Feb 25, 2020 | Option Exercise | $6.80 | 1,703 | 11,580 | 14,128 | Feb 26, 2020, 07:33 PM |
| Boissel Stephane | EVP, Corp. Strategy | Feb 25, 2020 | Option Exercise | $6.80 | 2,384 | 16,211 | 15,116 | Feb 26, 2020, 07:31 PM |
| Macrae Sandy | President and CEO | Feb 25, 2020 | Option Exercise | $6.80 | 7,264 | 49,395 | 79,229 | Feb 26, 2020, 07:29 PM |
| Macrae Sandy | President and CEO | Jan 24, 2020 | Option Exercise | $7.50 | 4,283 | 32,123 | 86,493 | Jan 28, 2020, 07:11 PM |
| Boissel Stephane | EVP, Corp. Strat. & Int. CFO | Aug 12, 2019 | Option Exercise | $11.23 | 11,137 | 125,069 | 17,500 | Aug 14, 2019, 05:10 PM |
| Yi Kathy | EVP & Chief Financial Officer | May 15, 2019 | Option Exercise | $4.55 | 5,000 | 22,750 | 30,512 | May 17, 2019, 05:41 PM |
| Yi Kathy | EVP & Chief Financial Officer | May 15, 2019 | Sale | $10.00 | 5,000 | 50,000 | 25,512 | May 17, 2019, 05:41 PM |
| Yi Kathy | EVP & Chief Financial Officer | Apr 15, 2019 | Option Exercise | $4.55 | 5,000 | 22,750 | 30,512 | Apr 16, 2019, 07:27 PM |
| Yi Kathy | EVP & Chief Financial Officer | Apr 15, 2019 | Sale | $12.11 | 5,000 | 60,550 | 25,512 | Apr 16, 2019, 07:27 PM |
| Yi Kathy | EVP & Chief Financial Officer | Mar 15, 2019 | Option Exercise | $4.55 | 5,000 | 22,750 | 30,512 | Mar 18, 2019, 07:35 PM |
| Yi Kathy | EVP & Chief Financial Officer | Mar 15, 2019 | Sale | $10.00 | 5,000 | 50,000 | 25,512 | Mar 18, 2019, 07:35 PM |
| Yi Kathy | EVP & Chief Financial Officer | Mar 01, 2019 | Option Exercise | $4.55 | 5,000 | 22,750 | 30,512 | Mar 05, 2019, 08:21 PM |
| Yi Kathy | EVP & Chief Financial Officer | Mar 01, 2019 | Sale | $10.00 | 5,000 | 50,000 | 25,512 | Mar 05, 2019, 08:21 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Jan 24, 2019 | Option Exercise | $11.10 | 834 | 9,257 | 11,291 | Jan 28, 2019, 05:46 PM |
| Yi Kathy | SVP & Chief Financial Officer | Jan 24, 2019 | Option Exercise | $11.10 | 988 | 10,967 | 6,262 | Jan 28, 2019, 05:45 PM |
| Macrae Sandy | President and CEO | Jan 24, 2018 | Option Exercise | $11.10 | 3,974 | 44,111 | 27,526 | Jan 28, 2019, 05:45 PM |
| Yi Kathy | SVP & Chief Financial Officer | Jan 15, 2019 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Jan 16, 2019, 04:08 PM |
| Yi Kathy | SVP & Chief Financial Officer | Jan 15, 2019 | Sale | $11.04 | 5,000 | 55,200 | 7,250 | Jan 16, 2019, 04:08 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Jan 07, 2019 | Option Exercise | $3.20 | 5,000 | 16,000 | 17,125 | Jan 08, 2019, 05:38 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Jan 07, 2019 | Sale | $12.33 | 5,000 | 61,631 | 12,125 | Jan 08, 2019, 05:38 PM |
| Yi Kathy | SVP & Chief Financial Officer | Dec 17, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Dec 18, 2018, 05:35 PM |
| Yi Kathy | SVP & Chief Financial Officer | Dec 17, 2018 | Sale | $11.44 | 5,000 | 57,200 | 7,250 | Dec 18, 2018, 05:35 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Dec 06, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 17,125 | Dec 07, 2018, 07:46 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Dec 06, 2018 | Sale | $11.49 | 5,000 | 57,433 | 12,125 | Dec 07, 2018, 07:46 PM |
| Yi Kathy | SVP & Chief Financial Officer | Nov 15, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Nov 16, 2018, 05:16 PM |
| Yi Kathy | SVP & Chief Financial Officer | Nov 15, 2018 | Sale | $10.00 | 5,000 | 50,000 | 7,250 | Nov 16, 2018, 05:16 PM |
| PARKER H STEWART | Director | Nov 14, 2018 | Buy | $9.00 | 2,000 | 18,002 | 7,500 | Nov 15, 2018, 07:08 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Nov 06, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 17,125 | Nov 07, 2018, 05:41 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Nov 06, 2018 | Sale | $13.73 | 5,000 | 68,650 | 12,125 | Nov 07, 2018, 05:41 PM |
| Yi Kathy | SVP & Chief Financial Officer | Oct 15, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Oct 16, 2018, 07:25 PM |
| Yi Kathy | SVP & Chief Financial Officer | Oct 15, 2018 | Sale | $13.97 | 5,000 | 69,850 | 7,250 | Oct 16, 2018, 07:25 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Oct 08, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 15,125 | Oct 09, 2018, 05:40 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Oct 08, 2018 | Sale | $14.55 | 5,000 | 72,773 | 10,125 | Oct 09, 2018, 05:40 PM |
| Yi Kathy | SVP & Chief Financial Officer | Sep 17, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Sep 18, 2018, 05:06 PM |
| Yi Kathy | SVP & Chief Financial Officer | Sep 17, 2018 | Sale | $14.66 | 5,000 | 73,285 | 7,250 | Sep 18, 2018, 05:06 PM |
| JEFFS ROGER | Director | Sep 07, 2018 | Buy | $13.56 | 7,408 | 100,487 | 9,908 | Sep 07, 2018, 07:18 PM |
| PARKER H STEWART | Director | Sep 07, 2018 | Buy | $13.52 | 2,000 | 27,040 | 5,500 | Sep 07, 2018, 05:45 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Sep 06, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 15,125 | Sep 07, 2018, 04:39 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Sep 06, 2018 | Sale | $14.17 | 5,000 | 70,845 | 10,125 | Sep 07, 2018, 04:39 PM |
| Yi Kathy | SVP & Chief Financial Officer | Aug 16, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Aug 17, 2018, 04:17 PM |
| Yi Kathy | SVP & Chief Financial Officer | Aug 16, 2018 | Sale | $15.39 | 5,000 | 76,951 | 7,250 | Aug 17, 2018, 04:17 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Aug 06, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 15,125 | Aug 07, 2018, 07:28 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Aug 06, 2018 | Sale | $13.45 | 5,000 | 67,250 | 10,125 | Aug 07, 2018, 07:28 PM |
| Yi Kathy | SVP & Chief Financial Officer | Jul 16, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Jul 17, 2018, 04:16 PM |
| Yi Kathy | SVP & Chief Financial Officer | Jul 16, 2018 | Sale | $14.77 | 5,000 | 73,860 | 7,250 | Jul 17, 2018, 04:16 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Jul 06, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 15,125 | Jul 09, 2018, 06:58 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Jul 06, 2018 | Sale | $15.80 | 5,000 | 78,975 | 10,125 | Jul 09, 2018, 06:58 PM |
| Yi Kathy | SVP & Chief Financial Officer | Jun 15, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Jun 15, 2018, 07:43 PM |
| Yi Kathy | SVP & Chief Financial Officer | Jun 15, 2018 | Sale | $15.67 | 5,000 | 78,365 | 7,250 | Jun 15, 2018, 07:43 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Jun 06, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 15,125 | Jun 07, 2018, 04:06 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Jun 06, 2018 | Sale | $16.67 | 5,000 | 83,350 | 10,125 | Jun 07, 2018, 04:06 PM |
| Yi Kathy | SVP & Chief Financial Officer | May 15, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | May 16, 2018, 06:38 PM |
| Yi Kathy | SVP & Chief Financial Officer | May 15, 2018 | Sale | $15.38 | 5,000 | 76,920 | 7,250 | May 16, 2018, 06:38 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | May 07, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 15,125 | May 09, 2018, 05:38 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | May 07, 2018 | Sale | $16.36 | 5,000 | 81,814 | 10,125 | May 09, 2018, 05:38 PM |
| Yi Kathy | SVP & Chief Financial Officer | Apr 16, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Apr 18, 2018, 04:04 PM |
| Yi Kathy | SVP & Chief Financial Officer | Apr 16, 2018 | Sale | $19.83 | 5,000 | 99,144 | 7,250 | Apr 18, 2018, 04:04 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Apr 13, 2018 | Option Exercise | $14.07 | 8,163 | 114,853 | 22,788 | Apr 17, 2018, 04:16 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Apr 13, 2018 | Sale | $20.00 | 8,163 | 163,260 | 14,625 | Apr 17, 2018, 04:16 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Apr 06, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 13,125 | Apr 09, 2018, 06:43 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Apr 06, 2018 | Sale | $17.41 | 5,000 | 87,065 | 8,125 | Apr 09, 2018, 06:43 PM |
| Mento Steven J | Director | Apr 02, 2018 | Option Exercise | $7.77 | 10,000 | 77,700 | 19,047 | Apr 04, 2018, 04:10 PM |
| Mento Steven J | Director | Apr 02, 2018 | Sale | $18.40 | 7,215 | 132,758 | 11,932 | Apr 04, 2018, 04:10 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Apr 02, 2018 | Option Exercise | $5.35 | 2,278 | 12,199 | 16,903 | Apr 04, 2018, 04:09 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Apr 02, 2018 | Sale | $18.30 | 2,278 | 41,684 | 14,625 | Apr 04, 2018, 04:09 PM |
| Yi Kathy | SVP & Chief Financial Officer | Mar 15, 2018 | Option Exercise | $4.55 | 5,000 | 22,750 | 12,250 | Mar 16, 2018, 07:41 PM |
| Yi Kathy | SVP & Chief Financial Officer | Mar 15, 2018 | Sale | $25.56 | 5,000 | 127,812 | 7,250 | Mar 16, 2018, 07:41 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Mar 06, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 13,125 | Mar 07, 2018, 08:43 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Mar 06, 2018 | Sale | $24.78 | 5,000 | 123,877 | 8,125 | Mar 07, 2018, 08:43 PM |
| Mento Steven J | Director | Mar 01, 2018 | Option Exercise | $5.49 | 15,000 | 82,350 | 18,480 | Mar 05, 2018, 06:50 PM |
| Mento Steven J | Director | Mar 01, 2018 | Sale | $23.27 | 9,433 | 219,546 | 9,047 | Mar 05, 2018, 06:50 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Mar 01, 2018 | Option Exercise | $9.86 | 15,000 | 147,905 | 29,625 | Mar 05, 2018, 06:39 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Mar 01, 2018 | Sale | $23.06 | 15,000 | 345,861 | 14,625 | Mar 05, 2018, 06:39 PM |
| Ramasastry Saira | Director | Feb 26, 2018 | Option Exercise | $5.03 | 9,450 | 47,534 | 9,450 | Feb 27, 2018, 06:41 PM |
| Ramasastry Saira | Director | Feb 26, 2018 | Sale | $24.88 | 9,450 | 235,080 | 0 | Feb 27, 2018, 06:41 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Feb 06, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 13,125 | Feb 07, 2018, 05:17 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Feb 06, 2018 | Sale | $18.49 | 5,000 | 92,436 | 8,125 | Feb 07, 2018, 05:17 PM |
| Mento Steven J | Director | Feb 01, 2018 | Option Exercise | $8.92 | 15,000 | 133,750 | 15,000 | Feb 05, 2018, 08:05 PM |
| Mento Steven J | Director | Feb 01, 2018 | Sale | $20.59 | 11,520 | 237,159 | 3,480 | Feb 05, 2018, 08:05 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Feb 01, 2018 | Option Exercise | $3.50 | 15,000 | 52,500 | 29,625 | Feb 05, 2018, 08:04 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Feb 01, 2018 | Sale | $20.59 | 15,000 | 308,854 | 14,625 | Feb 05, 2018, 08:04 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Jan 08, 2018 | Option Exercise | $3.20 | 5,000 | 16,000 | 7,000 | Jan 10, 2018, 05:51 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Jan 08, 2018 | Sale | $17.11 | 5,000 | 85,545 | 2,000 | Jan 10, 2018, 05:51 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Jan 02, 2018 | Option Exercise | $9.30 | 991 | 9,212 | 13,224 | Jan 04, 2018, 07:34 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Jan 03, 2018 | Option Exercise | $12.12 | 8,026 | 97,275 | 14,276 | Jan 04, 2018, 07:34 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Jan 02, 2018 | Sale | $16.35 | 6,974 | 114,025 | 6,250 | Jan 04, 2018, 07:34 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Jan 03, 2018 | Sale | $18.05 | 8,026 | 144,869 | 6,250 | Jan 04, 2018, 07:34 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Dec 11, 2017 | Option Exercise | $15.85 | 1,252 | 19,844 | 12,233 | Dec 12, 2017, 06:08 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Dec 08, 2017 | Option Exercise | $16.90 | 2,348 | 39,681 | 13,485 | Dec 12, 2017, 06:08 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Dec 06, 2017 | Option Exercise | $3.20 | 5,000 | 16,000 | 5,000 | Dec 08, 2017, 06:53 PM |
| Conner Edward R. | Sr. VP & Chief Medical Officer | Dec 06, 2017 | Sale | $16.24 | 5,000 | 81,200 | 0 | Dec 08, 2017, 06:53 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Dec 04, 2017 | Option Exercise | $12.12 | 11,803 | 143,052 | 27,636 | Dec 06, 2017, 07:17 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Dec 04, 2017 | Sale | $18.00 | 11,803 | 212,454 | 15,833 | Dec 06, 2017, 07:17 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Dec 01, 2017 | Option Exercise | $9.22 | 1,197 | 11,039 | 19,030 | Dec 04, 2017, 08:06 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Nov 30, 2017 | Option Exercise | $9.41 | 13,433 | 126,405 | 31,266 | Dec 04, 2017, 08:06 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Dec 01, 2017 | Sale | $16.70 | 3,197 | 53,390 | 15,833 | Dec 04, 2017, 08:06 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Nov 30, 2017 | Sale | $16.00 | 13,433 | 214,928 | 17,833 | Dec 04, 2017, 08:06 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Dec 01, 2017 | Option Exercise | $9.22 | 1,197 | 11,039 | 19,030 | Dec 04, 2017, 07:39 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Nov 30, 2017 | Option Exercise | $9.41 | 13,433 | 126,405 | 31,266 | Dec 04, 2017, 07:39 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Dec 01, 2017 | Sale | $16.70 | 3,197 | 53,390 | 15,833 | Dec 04, 2017, 07:39 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Nov 30, 2017 | Sale | $16.00 | 13,433 | 214,928 | 17,833 | Dec 04, 2017, 07:39 PM |
| Ramasastry Saira | Director | Nov 17, 2017 | Option Exercise | $5.03 | 5,000 | 25,150 | 5,000 | Nov 21, 2017, 05:01 PM |
| Ramasastry Saira | Director | Nov 17, 2017 | Sale | $14.67 | 5,000 | 73,339 | 0 | Nov 21, 2017, 05:01 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Oct 02, 2017 | Option Exercise | $7.66 | 15,000 | 114,905 | 21,663 | Oct 04, 2017, 04:22 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Oct 02, 2017 | Sale | $15.25 | 15,000 | 228,754 | 15,833 | Oct 04, 2017, 04:22 PM |
| RINGO WILLIAM R | Director | Sep 20, 2017 | Option Exercise | $6.05 | 31,000 | 187,550 | 31,800 | Sep 22, 2017, 04:04 PM |
| RINGO WILLIAM R | Director | Sep 20, 2017 | Sale | $14.37 | 31,000 | 445,597 | 800 | Sep 22, 2017, 04:04 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Sep 01, 2017 | Option Exercise | $5.41 | 10,316 | 55,810 | 26,149 | Sep 01, 2017, 06:19 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Sep 01, 2017 | Sale | $15.00 | 15,000 | 225,000 | 15,833 | Sep 01, 2017, 06:19 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Aug 14, 2017 | Option Exercise | $5.12 | 5,000 | 25,600 | 25,517 | Aug 15, 2017, 05:31 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Aug 11, 2017 | Option Exercise | $3.32 | 6,474 | 21,511 | 26,991 | Aug 15, 2017, 05:31 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Aug 11, 2017 | Sale | $10.00 | 6,474 | 64,740 | 20,517 | Aug 15, 2017, 05:31 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Aug 14, 2017 | Sale | $11.00 | 5,000 | 55,000 | 20,517 | Aug 15, 2017, 05:31 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Jul 14, 2017 | Option Exercise | $3.99 | 172 | 686 | 35,517 | Jul 14, 2017, 08:06 PM |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | Jul 14, 2017 | Sale | $10.00 | 15,000 | 150,000 | 35,345 | Jul 14, 2017, 08:06 PM |
| Herberts Curt A. III | Senior VP & CBO | Jun 01, 2017 | Sale | $6.80 | 2,000 | 13,600 | 35,345 | Jun 02, 2017, 08:26 PM |
| Herberts Curt A. III | Senior VP & CBO | May 11, 2017 | Sale | $6.50 | 639 | 4,154 | 39,345 | May 15, 2017, 07:42 PM |
| Herberts Curt A. III | Senior VP & CBO | May 12, 2017 | Sale | $8.50 | 2,000 | 17,000 | 37,345 | May 15, 2017, 07:42 PM |
| Herberts Curt A. III | Senior VP & CBO | Dec 12, 2016 | Option Exercise | $3.05 | 4,852 | 14,799 | 33,300 | Dec 14, 2016, 08:11 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 12, 2015 | Option Exercise | $3.05 | 13,778 | 42,023 | 206,829 | Dec 14, 2016, 08:03 PM |
| LANPHIER EDWARD O II | Director | Jun 13, 2016 | Option Exercise | $6.23 | 84,642 | 527,320 | 223,938 | Jun 15, 2016, 08:22 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 12, 2015 | Option Exercise | $8.68 | 4,000 | 34,720 | 107,328 | Dec 15, 2015, 05:12 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 11, 2015 | Option Exercise | $8.68 | 4,348 | 37,741 | 111,328 | Dec 15, 2015, 05:12 PM |
| LANPHIER EDWARD O II | President & CEO | Dec 12, 2015 | Option Exercise | $8.68 | 13,045 | 113,231 | 293,906 | Dec 15, 2015, 05:11 PM |
| LANPHIER EDWARD O II | President & CEO | Dec 11, 2015 | Option Exercise | $8.68 | 21,741 | 188,712 | 306,951 | Dec 15, 2015, 05:11 PM |
| NICHOL GEOFFREY | Executive Vice President, R&D | Dec 12, 2015 | Option Exercise | $8.68 | 4,384 | 38,053 | 159,676 | Dec 15, 2015, 05:11 PM |
| NICHOL GEOFFREY | Executive Vice President, R&D | Dec 11, 2015 | Option Exercise | $8.68 | 4,697 | 40,770 | 164,060 | Dec 15, 2015, 05:11 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 12, 2015 | Option Exercise | $8.68 | 6,087 | 52,835 | 215,703 | Dec 15, 2015, 05:09 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 11, 2015 | Option Exercise | $8.68 | 6,522 | 56,611 | 221,790 | Dec 15, 2015, 05:09 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 07, 2015 | Option Exercise | $9.69 | 6,087 | 58,983 | 115,676 | Dec 09, 2015, 04:53 PM |
| LANPHIER EDWARD O II | President & CEO | Dec 07, 2015 | Option Exercise | $9.69 | 31,308 | 303,375 | 328,692 | Dec 09, 2015, 04:51 PM |
| NICHOL GEOFFREY | Executive Vice President, R&D | Dec 07, 2015 | Option Exercise | $9.69 | 6,889 | 66,754 | 168,757 | Dec 09, 2015, 04:50 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 07, 2015 | Option Exercise | $9.69 | 7,060 | 68,411 | 228,312 | Dec 09, 2015, 04:47 PM |
| LANPHIER EDWARD O II | President & CEO | Jul 15, 2015 | Option Exercise | $6.82 | 25,000 | 170,500 | 260,000 | Jul 17, 2015, 04:49 PM |
| LANPHIER EDWARD O II | President & CEO | Jul 15, 2015 | Sale | $10.43 | 25,000 | 260,770 | 235,000 | Jul 17, 2015, 04:49 PM |
| Wolff Henry Ward | Exec VP & CFO | Jul 13, 2015 | Option Exercise | $3.45 | 3,898 | 13,448 | 203,770 | Jul 14, 2015, 04:46 PM |
| Wolff Henry Ward | Exec VP & CFO | Jul 10, 2015 | Option Exercise | $3.45 | 6,102 | 21,052 | 205,974 | Jul 14, 2015, 04:46 PM |
| Wolff Henry Ward | Exec VP & CFO | Jul 13, 2015 | Sale | $10.00 | 5,898 | 58,980 | 199,872 | Jul 14, 2015, 04:46 PM |
| Wolff Henry Ward | Exec VP & CFO | Jul 10, 2015 | Sale | $10.00 | 6,102 | 61,020 | 199,872 | Jul 14, 2015, 04:46 PM |
| LANPHIER EDWARD O II | President & CEO | Jun 15, 2015 | Option Exercise | $6.82 | 25,000 | 170,500 | 260,000 | Jun 17, 2015, 04:47 PM |
| LANPHIER EDWARD O II | President & CEO | Jun 15, 2015 | Sale | $11.08 | 25,000 | 277,078 | 235,000 | Jun 17, 2015, 04:47 PM |
| Wolff Henry Ward | Exec VP & CFO | Jun 10, 2015 | Option Exercise | $3.45 | 10,000 | 34,500 | 211,872 | Jun 12, 2015, 04:50 PM |
| Wolff Henry Ward | Exec VP & CFO | Jun 10, 2015 | Sale | $12.21 | 12,000 | 146,558 | 201,872 | Jun 12, 2015, 04:50 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jun 05, 2015 | Option Exercise | $3.45 | 15,000 | 51,750 | 111,763 | Jun 09, 2015, 05:26 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jun 05, 2015 | Sale | $12.29 | 15,000 | 184,394 | 96,763 | Jun 09, 2015, 05:26 PM |
| RINGO WILLIAM R | Director | Jun 03, 2015 | Option Exercise | $6.05 | 2,200 | 13,310 | 3,000 | Jun 03, 2015, 09:07 PM |
| RINGO WILLIAM R | Director | Jun 03, 2015 | Sale | $12.44 | 2,200 | 27,364 | 800 | Jun 03, 2015, 09:07 PM |
| Gregory Philip D | SVP of Research & CSO | Jun 01, 2015 | Option Exercise | $5.13 | 15,000 | 77,000 | 131,410 | Jun 03, 2015, 09:06 PM |
| Gregory Philip D | SVP of Research & CSO | Jun 01, 2015 | Sale | $12.39 | 15,000 | 185,816 | 116,410 | Jun 03, 2015, 09:06 PM |
| LANPHIER EDWARD O II | President & CEO | May 15, 2015 | Option Exercise | $6.82 | 25,000 | 170,500 | 260,000 | May 19, 2015, 05:26 PM |
| LANPHIER EDWARD O II | President & CEO | May 15, 2015 | Sale | $11.51 | 25,000 | 287,862 | 235,000 | May 19, 2015, 05:26 PM |
| Wolff Henry Ward | Exec VP & CFO | May 11, 2015 | Option Exercise | $3.45 | 10,000 | 34,500 | 213,872 | May 13, 2015, 04:40 PM |
| Wolff Henry Ward | Exec VP & CFO | May 11, 2015 | Sale | $13.25 | 12,000 | 158,949 | 203,872 | May 13, 2015, 04:40 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | May 05, 2015 | Option Exercise | $3.45 | 15,000 | 51,750 | 110,376 | May 05, 2015, 07:26 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | May 05, 2015 | Sale | $12.29 | 15,000 | 184,297 | 95,376 | May 05, 2015, 07:26 PM |
| RINGO WILLIAM R | Director | May 04, 2015 | Option Exercise | $6.19 | 3,000 | 18,582 | 3,800 | May 05, 2015, 07:23 PM |
| RINGO WILLIAM R | Director | May 04, 2015 | Sale | $12.98 | 3,000 | 38,927 | 800 | May 05, 2015, 07:23 PM |
| Gregory Philip D | SVP of Research & CSO | May 01, 2015 | Option Exercise | $5.13 | 15,000 | 77,000 | 131,410 | May 05, 2015, 07:05 PM |
| Gregory Philip D | SVP of Research & CSO | May 01, 2015 | Sale | $12.62 | 15,000 | 189,370 | 116,410 | May 05, 2015, 07:05 PM |
| LANPHIER EDWARD O II | President & CEO | Apr 15, 2015 | Option Exercise | $6.82 | 25,000 | 170,500 | 260,000 | Apr 17, 2015, 07:03 PM |
| LANPHIER EDWARD O II | President & CEO | Apr 15, 2015 | Sale | $15.33 | 25,000 | 383,260 | 235,000 | Apr 17, 2015, 07:03 PM |
| Wolff Henry Ward | Exec VP & CFO | Apr 10, 2015 | Option Exercise | $3.45 | 10,000 | 34,500 | 214,849 | Apr 14, 2015, 07:03 PM |
| Wolff Henry Ward | Exec VP & CFO | Apr 10, 2015 | Sale | $15.31 | 12,000 | 183,771 | 204,849 | Apr 14, 2015, 07:03 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Apr 06, 2015 | Option Exercise | $3.45 | 15,000 | 51,750 | 110,376 | Apr 08, 2015, 07:06 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Apr 06, 2015 | Sale | $14.94 | 15,000 | 224,172 | 95,376 | Apr 08, 2015, 07:06 PM |
| RINGO WILLIAM R | Director | Apr 06, 2015 | Option Exercise | $6.41 | 2,200 | 14,102 | 3,000 | Apr 08, 2015, 07:05 PM |
| RINGO WILLIAM R | Director | Apr 06, 2015 | Sale | $14.95 | 2,200 | 32,881 | 800 | Apr 08, 2015, 07:05 PM |
| Gregory Philip D | SVP of Research & CSO | Apr 01, 2015 | Option Exercise | $5.13 | 15,000 | 77,000 | 131,410 | Apr 03, 2015, 07:53 PM |
| Gregory Philip D | SVP of Research & CSO | Apr 01, 2015 | Sale | $15.15 | 15,000 | 227,192 | 116,410 | Apr 03, 2015, 07:53 PM |
| Wolff Henry Ward | Exec VP & CFO | Mar 19, 2015 | Option Exercise | $14.27 | 10,000 | 142,700 | 214,849 | Mar 20, 2015, 07:28 PM |
| Wolff Henry Ward | Exec VP & CFO | Mar 19, 2015 | Sale | $18.00 | 10,000 | 180,000 | 204,849 | Mar 20, 2015, 07:28 PM |
| LANPHIER EDWARD O II | President & CEO | Mar 16, 2015 | Option Exercise | $6.82 | 25,000 | 170,500 | 260,000 | Mar 18, 2015, 08:02 PM |
| LANPHIER EDWARD O II | President & CEO | Mar 16, 2015 | Sale | $17.29 | 25,000 | 432,305 | 235,000 | Mar 18, 2015, 08:02 PM |
| Wolff Henry Ward | Exec VP & CFO | Mar 10, 2015 | Option Exercise | $3.45 | 10,000 | 34,500 | 216,849 | Mar 12, 2015, 08:09 PM |
| Wolff Henry Ward | Exec VP & CFO | Mar 10, 2015 | Sale | $16.68 | 12,000 | 200,201 | 206,849 | Mar 12, 2015, 08:09 PM |
| Wolff Henry Ward | Exec VP & CFO | Mar 04, 2015 | Option Exercise | $14.27 | 10,000 | 142,700 | 216,849 | Mar 06, 2015, 07:04 PM |
| Wolff Henry Ward | Exec VP & CFO | Mar 04, 2015 | Sale | $18.00 | 10,000 | 180,000 | 206,849 | Mar 06, 2015, 07:04 PM |
| Mento Steven J | Director | Mar 05, 2015 | Option Exercise | $4.54 | 10,000 | 45,400 | 18,771 | Mar 06, 2015, 06:51 PM |
| Mento Steven J | Director | Mar 05, 2015 | Sale | $18.30 | 6,501 | 118,939 | 12,270 | Mar 06, 2015, 06:51 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Mar 05, 2015 | Option Exercise | $3.45 | 15,000 | 51,750 | 110,376 | Mar 06, 2015, 06:49 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Mar 05, 2015 | Sale | $18.29 | 15,000 | 274,282 | 95,376 | Mar 06, 2015, 06:49 PM |
| RINGO WILLIAM R | Director | Mar 03, 2015 | Option Exercise | $6.41 | 2,200 | 14,102 | 3,000 | Mar 04, 2015, 08:06 PM |
| RINGO WILLIAM R | Director | Mar 03, 2015 | Sale | $17.21 | 2,200 | 37,862 | 800 | Mar 04, 2015, 08:06 PM |
| Gregory Philip D | SVP of Research & CSO | Mar 02, 2015 | Option Exercise | $7.34 | 15,000 | 110,120 | 131,410 | Mar 04, 2015, 08:04 PM |
| Gregory Philip D | SVP of Research & CSO | Mar 02, 2015 | Sale | $17.26 | 15,000 | 258,938 | 116,410 | Mar 04, 2015, 08:04 PM |
| LANPHIER EDWARD O II | President & CEO | Feb 17, 2015 | Option Exercise | $6.82 | 25,000 | 170,500 | 260,000 | Feb 19, 2015, 08:05 PM |
| LANPHIER EDWARD O II | President & CEO | Feb 17, 2015 | Sale | $15.69 | 25,000 | 392,150 | 235,000 | Feb 19, 2015, 08:05 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 17, 2014 | Buy | $12.26 | 37,215 | 456,211 | 2,199,753 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Aug 01, 2014 | Sale | $12.82 | 27,770 | 356,100 | 1,829,426 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 01, 2014 | Sale | $16.01 | 82,700 | 1,323,999 | 2,212,158 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 30, 2014 | Sale | $12.42 | 109,590 | 1,361,606 | 1,946,194 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jun 16, 2014 | Sale | $16.55 | 250,500 | 4,146,531 | 2,493,900 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 29, 2014 | Sale | $12.41 | 1,407 | 17,464 | 1,966,786 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jun 09, 2014 | Sale | $15.50 | 83,500 | 1,294,159 | 2,518,283 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 28, 2014 | Sale | $12.11 | 60,081 | 727,474 | 2,003,464 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jun 06, 2014 | Sale | $14.29 | 135,101 | 1,930,949 | 2,704,487 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 25, 2014 | Sale | $12.31 | 47,429 | 583,951 | 2,028,274 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jun 05, 2014 | Sale | $14.13 | 115,102 | 1,626,669 | 2,763,188 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 24, 2014 | Sale | $12.28 | 124,050 | 1,523,235 | 2,075,703 | Feb 18, 2015, 09:54 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 07, 2014 | Buy | $12.09 | 35,736 | 431,870 | 4,857,972 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 27, 2014 | Sale | $13.55 | 263,437 | 3,570,473 | 4,426,386 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jun 05, 2014 | Sale | $13.06 | 970,361 | 12,669,888 | 2,881,303 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 23, 2014 | Sale | $13.27 | 51,597 | 684,713 | 4,580,960 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jun 04, 2014 | Sale | $13.10 | 70,640 | 925,227 | 3,849,783 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 22, 2014 | Sale | $13.56 | 56,396 | 764,537 | 4,673,375 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jun 03, 2014 | Sale | $12.86 | 76,833 | 988,072 | 3,870,442 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 13, 2014 | Sale | $13.12 | 56,060 | 735,305 | 4,688,953 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 30, 2014 | Sale | $13.40 | 65,884 | 883,147 | 3,971,508 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 12, 2014 | Sale | $13.03 | 29,659 | 386,330 | 4,755,283 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 29, 2014 | Sale | $13.53 | 155,675 | 2,106,559 | 4,159,444 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 08, 2014 | Sale | $12.40 | 83,300 | 1,032,587 | 4,837,147 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 28, 2014 | Sale | $13.43 | 148,689 | 1,996,952 | 4,193,136 | Feb 18, 2015, 09:53 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 08, 2014 | Buy | $15.49 | 121,876 | 1,888,274 | 4,596,900 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | May 07, 2014 | Buy | $11.73 | 47,564 | 557,989 | 4,822,236 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 07, 2014 | Buy | $15.42 | 33,667 | 519,310 | 4,475,024 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 15, 2014 | Buy | $13.16 | 21,829 | 287,206 | 4,742,407 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 30, 2014 | Buy | $13.45 | 124,500 | 1,674,679 | 4,774,672 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 04, 2014 | Buy | $15.38 | 179,031 | 2,753,712 | 4,441,357 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 11, 2014 | Buy | $14.48 | 116,992 | 1,694,299 | 4,723,633 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 28, 2014 | Buy | $13.29 | 74,844 | 995,014 | 4,650,172 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 03, 2014 | Buy | $16.61 | 195,126 | 3,241,999 | 4,262,326 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 25, 2014 | Buy | $13.63 | 166,000 | 2,262,779 | 4,575,328 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 10, 2014 | Buy | $14.91 | 83,000 | 1,237,339 | 4,610,044 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 17, 2014 | Buy | $14.02 | 41,500 | 581,959 | 4,762,078 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 16, 2014 | Sale | $14.09 | 21,829 | 307,658 | 4,720,578 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 14, 2014 | Sale | $14.78 | 3,055 | 45,165 | 4,720,578 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 10, 2014 | Sale | $15.67 | 3,403 | 53,326 | 4,606,641 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 22, 2014 | Sale | $14.86 | 352,750 | 5,243,538 | 4,722,487 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 09, 2014 | Sale | $16.27 | 69,856 | 1,136,424 | 4,527,044 | Feb 18, 2015, 09:52 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 13, 2014 | Buy | $22.76 | 71,319 | 1,623,356 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 26, 2014 | Buy | $18.14 | 210,013 | 3,808,711 | 3,977,013 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 25, 2014 | Buy | $19.42 | 84,000 | 1,631,041 | 3,767,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 10, 2014 | Buy | $22.30 | 12,522 | 279,180 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 21, 2014 | Buy | $21.22 | 101,808 | 2,159,989 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 07, 2014 | Buy | $22.25 | 258,377 | 5,748,552 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 28, 2014 | Buy | $17.10 | 84,000 | 1,436,056 | 4,317,200 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 17, 2014 | Buy | $23.02 | 52,161 | 1,200,835 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 27, 2014 | Buy | $17.65 | 256,187 | 4,522,356 | 4,233,200 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 12, 2014 | Sale | $23.40 | 123,480 | 2,889,432 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 19, 2014 | Sale | $24.28 | 17,808 | 432,432 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Apr 01, 2014 | Sale | $18.01 | 250,000 | 4,502,381 | 4,268,700 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 06, 2014 | Sale | $24.10 | 61,483 | 1,481,538 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 18, 2014 | Sale | $23.74 | 84,000 | 1,994,573 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 05, 2014 | Buy | $18.23 | 42,000 | 765,828 | 3,725,002 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 28, 2014 | Buy | $18.10 | 42,000 | 760,145 | 3,767,000 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 12, 2014 | Buy | $18.04 | 42,000 | 757,621 | 3,767,002 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 26, 2014 | Buy | $19.57 | 74,194 | 1,452,243 | 3,757,196 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 11, 2014 | Buy | $19.65 | 42,000 | 825,275 | 3,725,002 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 06, 2014 | Buy | $22.50 | 84,001 | 1,890,245 | 3,683,000 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 06, 2014 | Sale | $18.42 | 7,312 | 134,683 | 3,717,690 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 18, 2014 | Sale | $18.11 | 11,172 | 202,278 | 3,725,041 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 03, 2014 | Sale | $18.21 | 84,000 | 1,529,902 | 3,699,800 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 14, 2014 | Sale | $18.61 | 15,380 | 286,166 | 3,736,213 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 13, 2014 | Sale | $18.46 | 15,409 | 284,438 | 3,751,593 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 27, 2014 | Sale | $19.37 | 32,196 | 623,499 | 3,742,243 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 20, 2014 | Sale | $18.40 | 35,319 | 649,869 | 3,718,282 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Mar 06, 2014 | Sale | $23.28 | 293,417 | 6,831,412 | 3,683,000 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 07, 2014 | Sale | $18.52 | 34,688 | 642,432 | 3,683,002 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Feb 19, 2014 | Sale | $18.51 | 6,720 | 124,420 | 3,718,321 | Feb 18, 2015, 09:49 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner. | Dec 13, 2013 | Buy | $12.09 | 5,040 | 60,921 | 4,043,002 | Feb 18, 2015, 06:38 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner. | Dec 12, 2013 | Buy | $12.09 | 9,600 | 116,071 | 4,037,962 | Feb 18, 2015, 06:38 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner. | Jan 09, 2014 | Sale | $18.35 | 72,440 | 1,329,365 | 4,015,519 | Feb 18, 2015, 06:38 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 17, 2013 | Buy | $9.79 | 19,200 | 187,895 | 3,645,703 | Feb 18, 2015, 06:37 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 22, 2013 | Sale | $9.57 | 111,363 | 1,065,610 | 3,526,662 | Feb 18, 2015, 06:37 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 19, 2013 | Sale | $9.84 | 209,894 | 2,065,714 | 3,603,463 | Feb 18, 2015, 06:37 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 18, 2013 | Sale | $10.02 | 74,035 | 741,498 | 3,626,503 | Feb 18, 2015, 06:37 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 17, 2013 | Sale | $10.22 | 48,270 | 493,401 | 3,626,503 | Feb 18, 2015, 06:37 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 25, 2013 | Sale | $9.71 | 368,870 | 3,582,848 | 3,483,017 | Feb 18, 2015, 06:37 PM |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | Jul 23, 2013 | Sale | $9.37 | 5,012 | 46,938 | 3,487,088 | Feb 18, 2015, 06:37 PM |
| Ramasastry Saira | Director | Feb 12, 2015 | Option Exercise | $5.03 | 10,000 | 50,300 | 10,000 | Feb 13, 2015, 07:45 PM |
| Ramasastry Saira | Director | Feb 12, 2015 | Sale | $15.00 | 10,000 | 150,000 | 0 | Feb 13, 2015, 07:45 PM |
| Wolff Henry Ward | Exec VP & CFO | Feb 10, 2015 | Option Exercise | $3.45 | 10,000 | 34,500 | 218,849 | Feb 12, 2015, 08:14 PM |
| Wolff Henry Ward | Exec VP & CFO | Feb 10, 2015 | Sale | $12.65 | 12,000 | 151,750 | 208,849 | Feb 12, 2015, 08:14 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Feb 05, 2015 | Option Exercise | $6.10 | 15,000 | 91,509 | 110,376 | Feb 06, 2015, 07:50 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Feb 05, 2015 | Sale | $12.93 | 15,000 | 193,950 | 95,376 | Feb 06, 2015, 07:50 PM |
| RINGO WILLIAM R | Director | Feb 03, 2015 | Option Exercise | $6.41 | 2,200 | 14,102 | 3,000 | Feb 05, 2015, 08:19 PM |
| RINGO WILLIAM R | Director | Feb 03, 2015 | Sale | $12.70 | 2,200 | 27,940 | 800 | Feb 05, 2015, 08:19 PM |
| Gregory Philip D | SVP of Research & CSO | Feb 02, 2015 | Option Exercise | $5.13 | 15,000 | 77,000 | 131,410 | Feb 04, 2015, 07:31 PM |
| Gregory Philip D | SVP of Research & CSO | Feb 02, 2015 | Sale | $12.86 | 15,000 | 192,829 | 116,410 | Feb 04, 2015, 07:31 PM |
| LANPHIER EDWARD O II | President & CEO | Jan 16, 2015 | Option Exercise | $6.82 | 10,000 | 68,200 | 245,000 | Jan 16, 2015, 08:20 PM |
| LANPHIER EDWARD O II | President & CEO | Jan 15, 2015 | Option Exercise | $6.82 | 15,000 | 102,300 | 250,000 | Jan 16, 2015, 08:20 PM |
| LANPHIER EDWARD O II | President & CEO | Jan 16, 2015 | Sale | $14.29 | 10,000 | 142,853 | 235,000 | Jan 16, 2015, 08:20 PM |
| LANPHIER EDWARD O II | President & CEO | Jan 15, 2015 | Sale | $14.18 | 15,000 | 212,769 | 236,600 | Jan 16, 2015, 08:20 PM |
| Wolff Henry Ward | Exec VP & CFO | Jan 12, 2015 | Option Exercise | $3.45 | 10,000 | 34,500 | 220,849 | Jan 14, 2015, 07:02 PM |
| Wolff Henry Ward | Exec VP & CFO | Jan 12, 2015 | Sale | $15.87 | 12,000 | 190,450 | 210,849 | Jan 14, 2015, 07:02 PM |
| RINGO WILLIAM R | Director | Jan 05, 2015 | Option Exercise | $6.41 | 2,200 | 14,102 | 3,000 | Jan 06, 2015, 07:27 PM |
| RINGO WILLIAM R | Director | Jan 05, 2015 | Sale | $15.20 | 2,200 | 33,430 | 800 | Jan 06, 2015, 07:27 PM |
| LARSON JOHN WILLIAM | Director | Jan 05, 2015 | Option Exercise | $6.86 | 15,000 | 102,850 | 229,660 | Jan 06, 2015, 07:26 PM |
| LARSON JOHN WILLIAM | Director | Jan 05, 2015 | Sale | $15.10 | 15,000 | 226,550 | 214,660 | Jan 06, 2015, 07:26 PM |
| Gregory Philip D | SVP, Research & CSO | Jan 02, 2015 | Option Exercise | $7.34 | 15,000 | 110,120 | 131,410 | Jan 06, 2015, 07:25 PM |
| Gregory Philip D | SVP, Research & CSO | Jan 02, 2015 | Sale | $15.78 | 15,000 | 236,664 | 116,410 | Jan 06, 2015, 07:25 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jan 05, 2015 | Option Exercise | $6.82 | 15,000 | 102,300 | 110,376 | Jan 06, 2015, 07:24 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jan 05, 2015 | Sale | $15.19 | 15,000 | 227,854 | 95,976 | Jan 06, 2015, 07:24 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 15, 2014 | Option Exercise | $14.74 | 40,004 | 589,587 | 210,849 | Dec 17, 2014, 08:00 PM |
| NICHOL GEOFFREY | Executive Vice President, R&D | Dec 15, 2014 | Option Exercise | $14.74 | 41,743 | 615,217 | 138,146 | Dec 15, 2014, 09:51 PM |
| LANPHIER EDWARD O II | President & CEO | Dec 15, 2014 | Option Exercise | $14.74 | 96,533 | 1,422,723 | 323,467 | Dec 15, 2014, 09:49 PM |
| LANPHIER EDWARD O II | President & CEO | Dec 15, 2014 | Option Exercise | $4.11 | 25,000 | 102,750 | 348,467 | Dec 15, 2014, 09:49 PM |
| LANPHIER EDWARD O II | President & CEO | Dec 15, 2014 | Sale | $15.40 | 25,000 | 384,912 | 339,467 | Dec 15, 2014, 09:49 PM |
| LARSON JOHN WILLIAM | Director | Dec 15, 2014 | Option Exercise | $5.95 | 15,000 | 89,250 | 229,660 | Dec 15, 2014, 09:23 PM |
| LARSON JOHN WILLIAM | Director | Dec 15, 2014 | Sale | $16.28 | 10,000 | 162,829 | 214,660 | Dec 15, 2014, 09:23 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 15, 2014 | Option Exercise | $14.74 | 27,480 | 405,006 | 95,376 | Dec 15, 2014, 09:23 PM |
| Gregory Philip D | Vice President, Research & CSO | Dec 15, 2014 | Option Exercise | $14.74 | 30,437 | 448,587 | 116,410 | Dec 15, 2014, 09:22 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 15, 2014 | Option Exercise | $14.74 | 40,004 | 589,587 | 210,849 | Dec 15, 2014, 09:20 PM |
| Mento Steven J | Director | Dec 11, 2014 | Option Exercise | $4.10 | 10,000 | 41,000 | 35,069 | Dec 15, 2014, 08:00 PM |
| Mento Steven J | Director | Dec 11, 2014 | Sale | $15.00 | 6,354 | 95,310 | 28,715 | Dec 15, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 05, 2014 | Option Exercise | $6.82 | 15,000 | 102,300 | 112,856 | Dec 09, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 05, 2014 | Sale | $11.21 | 15,000 | 168,197 | 97,856 | Dec 09, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Dec 09, 2014 | Option Exercise | $4.54 | 10,000 | 45,400 | 224,660 | Dec 09, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Dec 09, 2014 | Sale | $12.00 | 10,000 | 120,000 | 214,660 | Dec 09, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Dec 01, 2014 | Option Exercise | $5.13 | 15,000 | 77,000 | 124,347 | Dec 03, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Dec 01, 2014 | Sale | $11.68 | 15,000 | 175,191 | 109,347 | Dec 03, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Nov 17, 2014 | Option Exercise | $4.11 | 25,000 | 102,750 | 320,000 | Nov 19, 2014, 08:01 PM |
| LANPHIER EDWARD O II | President & CEO | Nov 17, 2014 | Sale | $11.23 | 25,000 | 280,842 | 295,000 | Nov 19, 2014, 08:01 PM |
| Wolff Henry Ward | Exec VP & CFO | Nov 10, 2014 | Sale | $11.37 | 2,000 | 22,748 | 213,353 | Nov 13, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Nov 12, 2014 | Option Exercise | $4.10 | 10,000 | 41,000 | 224,660 | Nov 13, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Nov 12, 2014 | Sale | $12.00 | 10,000 | 120,007 | 214,660 | Nov 13, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Nov 05, 2014 | Option Exercise | $5.59 | 15,000 | 83,877 | 112,856 | Nov 07, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Nov 05, 2014 | Sale | $11.35 | 15,000 | 170,258 | 97,856 | Nov 07, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Nov 03, 2014 | Option Exercise | $5.28 | 15,000 | 79,240 | 124,347 | Nov 05, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Nov 03, 2014 | Sale | $11.91 | 15,000 | 178,704 | 109,347 | Nov 05, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Oct 28, 2014 | Option Exercise | $7.28 | 10,000 | 72,800 | 224,660 | Oct 30, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Oct 28, 2014 | Sale | $12.02 | 10,000 | 120,153 | 214,660 | Oct 30, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Oct 15, 2014 | Option Exercise | $4.11 | 25,000 | 102,750 | 320,000 | Oct 17, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Oct 15, 2014 | Sale | $10.49 | 25,000 | 262,365 | 295,000 | Oct 17, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Oct 10, 2014 | Sale | $10.10 | 2,000 | 20,200 | 214,347 | Oct 14, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Oct 06, 2014 | Option Exercise | $4.11 | 15,000 | 61,650 | 111,579 | Oct 08, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Oct 06, 2014 | Sale | $10.72 | 15,000 | 160,865 | 96,579 | Oct 08, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Oct 01, 2014 | Option Exercise | $5.66 | 15,000 | 84,840 | 124,347 | Oct 03, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Oct 01, 2014 | Sale | $10.80 | 15,000 | 162,028 | 109,347 | Oct 03, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Sep 15, 2014 | Option Exercise | $4.11 | 25,000 | 102,750 | 320,000 | Sep 17, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Sep 15, 2014 | Sale | $12.14 | 25,000 | 303,382 | 295,000 | Sep 17, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Sep 10, 2014 | Sale | $12.31 | 2,000 | 24,620 | 216,347 | Sep 12, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Sep 05, 2014 | Option Exercise | $4.11 | 15,000 | 61,650 | 111,579 | Sep 05, 2014, 09:45 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Sep 05, 2014 | Sale | $12.20 | 15,000 | 183,072 | 96,579 | Sep 05, 2014, 09:45 PM |
| LARSON JOHN WILLIAM | Director | Sep 04, 2014 | Option Exercise | $7.73 | 10,000 | 77,300 | 228,160 | Sep 05, 2014, 05:00 PM |
| LARSON JOHN WILLIAM | Director | Sep 04, 2014 | Sale | $12.81 | 10,000 | 128,082 | 218,160 | Sep 05, 2014, 05:00 PM |
| Gregory Philip D | SVP of Research & CSO | Sep 02, 2014 | Option Exercise | $5.66 | 15,000 | 84,840 | 124,347 | Sep 04, 2014, 05:00 PM |
| Gregory Philip D | SVP of Research & CSO | Sep 02, 2014 | Sale | $13.45 | 15,000 | 201,798 | 109,347 | Sep 04, 2014, 05:00 PM |
| LANPHIER EDWARD O II | President & CEO | Aug 15, 2014 | Option Exercise | $4.11 | 25,000 | 102,750 | 320,000 | Aug 15, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Aug 15, 2014 | Sale | $13.95 | 25,000 | 348,797 | 295,000 | Aug 15, 2014, 08:00 PM |
| Ramasastry Saira | Director | Aug 08, 2014 | Option Exercise | $5.03 | 10,000 | 50,300 | 10,000 | Aug 12, 2014, 08:00 PM |
| Ramasastry Saira | Director | Aug 08, 2014 | Sale | $14.00 | 10,000 | 140,000 | 0 | Aug 12, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Aug 11, 2014 | Option Exercise | $7.28 | 8,000 | 58,240 | 228,347 | Aug 12, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Aug 11, 2014 | Sale | $14.17 | 10,000 | 141,677 | 220,347 | Aug 12, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Aug 05, 2014 | Option Exercise | $4.11 | 13,202 | 54,260 | 111,579 | Aug 05, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Aug 05, 2014 | Sale | $12.99 | 15,000 | 194,846 | 98,377 | Aug 05, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Aug 04, 2014 | Option Exercise | $4.00 | 10,000 | 40,000 | 228,160 | Aug 05, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Aug 04, 2014 | Sale | $12.56 | 10,000 | 125,578 | 218,160 | Aug 05, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Aug 01, 2014 | Option Exercise | $5.66 | 15,000 | 84,840 | 124,347 | Aug 05, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Aug 01, 2014 | Sale | $12.54 | 15,000 | 188,149 | 109,347 | Aug 05, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Jul 18, 2014 | Option Exercise | $4.11 | 25,000 | 102,750 | 320,000 | Jul 18, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Jul 18, 2014 | Sale | $12.16 | 25,000 | 303,940 | 295,000 | Jul 18, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Jul 10, 2014 | Option Exercise | $7.66 | 13,000 | 99,590 | 235,347 | Jul 11, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Jul 10, 2014 | Sale | $13.26 | 15,000 | 198,902 | 222,347 | Jul 11, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Jul 01, 2014 | Option Exercise | $5.66 | 15,000 | 84,840 | 124,347 | Jul 03, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Jul 01, 2014 | Sale | $15.66 | 15,000 | 234,865 | 109,347 | Jul 03, 2014, 08:00 PM |
| Ramasastry Saira | Director | Jun 23, 2014 | Option Exercise | $5.03 | 5,550 | 27,917 | 5,550 | Jun 25, 2014, 08:00 PM |
| Ramasastry Saira | Director | Jun 23, 2014 | Sale | $15.53 | 5,550 | 86,217 | 0 | Jun 25, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Jun 16, 2014 | Sale | $16.41 | 25,000 | 410,138 | 1,516,054 | Jun 18, 2014, 08:00 PM |
| Mento Steven J | Director | Jun 09, 2014 | Option Exercise | $7.28 | 5,834 | 42,472 | 29,397 | Jun 11, 2014, 08:00 PM |
| Mento Steven J | Director | Jun 09, 2014 | Sale | $15.00 | 4,328 | 64,920 | 25,069 | Jun 11, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Jun 10, 2014 | Option Exercise | $7.73 | 13,000 | 100,490 | 237,347 | Jun 11, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Jun 10, 2014 | Sale | $15.62 | 15,000 | 234,328 | 224,347 | Jun 11, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Jun 02, 2014 | Option Exercise | $5.66 | 15,000 | 84,840 | 124,347 | Jun 04, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | Jun 02, 2014 | Sale | $12.85 | 15,000 | 192,723 | 109,347 | Jun 04, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | May 27, 2014 | Option Exercise | $3.68 | 15,000 | 55,230 | 111,377 | May 29, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | May 27, 2014 | Sale | $13.57 | 15,000 | 203,531 | 98,377 | May 29, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | May 15, 2014 | Sale | $13.14 | 25,000 | 328,542 | 1,541,054 | May 16, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | May 12, 2014 | Option Exercise | $7.73 | 13,000 | 100,490 | 239,347 | May 14, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | May 12, 2014 | Sale | $12.85 | 15,000 | 192,756 | 226,347 | May 14, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | May 01, 2014 | Option Exercise | $5.66 | 15,000 | 84,840 | 124,347 | May 02, 2014, 08:00 PM |
| Gregory Philip D | SVP of Research & CSO | May 01, 2014 | Sale | $13.68 | 15,000 | 205,179 | 109,347 | May 02, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Apr 28, 2014 | Option Exercise | $3.68 | 15,000 | 55,230 | 110,015 | Apr 30, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Apr 28, 2014 | Sale | $13.64 | 15,000 | 204,532 | 97,015 | Apr 30, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Apr 28, 2014 | Option Exercise | $5.66 | 10,000 | 56,600 | 228,160 | Apr 30, 2014, 08:00 PM |
| LARSON JOHN WILLIAM | Director | Apr 28, 2014 | Sale | $13.48 | 10,000 | 134,786 | 218,160 | Apr 30, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Apr 15, 2014 | Sale | $14.20 | 25,000 | 355,012 | 1,566,054 | Apr 17, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Apr 10, 2014 | Option Exercise | $7.73 | 13,000 | 100,490 | 240,347 | Apr 11, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Apr 10, 2014 | Sale | $15.72 | 15,000 | 235,798 | 227,347 | Apr 11, 2014, 08:00 PM |
| Gregory Philip D | Sr. VP Res. & CSO | Apr 01, 2014 | Option Exercise | $7.57 | 15,000 | 113,480 | 124,347 | Apr 03, 2014, 08:01 PM |
| Gregory Philip D | Sr. VP Res. & CSO | Apr 01, 2014 | Sale | $17.80 | 15,000 | 267,000 | 109,347 | Apr 03, 2014, 08:01 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Mar 26, 2014 | Option Exercise | $3.68 | 15,000 | 55,230 | 110,015 | Mar 28, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Mar 26, 2014 | Sale | $18.65 | 15,000 | 279,695 | 97,215 | Mar 28, 2014, 08:00 PM |
| Gregory Philip D | See Remarks | Mar 21, 2014 | Option Exercise | $7.64 | 15,000 | 114,662 | 124,347 | Mar 25, 2014, 08:00 PM |
| Gregory Philip D | See Remarks | Mar 21, 2014 | Sale | $22.38 | 15,000 | 335,763 | 109,347 | Mar 25, 2014, 08:00 PM |
| Ramasastry Saira | Director | Mar 17, 2014 | Option Exercise | $5.03 | 10,000 | 50,300 | 10,000 | Mar 17, 2014, 08:02 PM |
| Ramasastry Saira | Director | Mar 17, 2014 | Sale | $23.26 | 10,000 | 232,608 | 0 | Mar 17, 2014, 08:02 PM |
| Mento Steven J | Director | Mar 14, 2014 | Option Exercise | $3.87 | 9,722 | 37,624 | 29,666 | Mar 17, 2014, 08:00 PM |
| Mento Steven J | Director | Mar 14, 2014 | Sale | $22.77 | 6,103 | 138,955 | 23,563 | Mar 17, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Mar 17, 2014 | Option Exercise | $5.19 | 50,000 | 259,500 | 345,000 | Mar 17, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Mar 17, 2014 | Sale | $23.22 | 50,000 | 1,160,930 | 295,000 | Mar 17, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Mar 10, 2014 | Option Exercise | $3.45 | 10,000 | 34,500 | 237,347 | Mar 12, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Mar 10, 2014 | Sale | $22.31 | 10,000 | 223,071 | 227,347 | Mar 12, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Feb 26, 2014 | Option Exercise | $3.68 | 15,000 | 55,230 | 110,015 | Feb 28, 2014, 08:01 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Feb 26, 2014 | Sale | $19.72 | 15,000 | 295,752 | 97,015 | Feb 28, 2014, 08:01 PM |
| LANPHIER EDWARD O II | President & CEO | Feb 18, 2014 | Option Exercise | $5.19 | 50,000 | 259,500 | 345,000 | Feb 19, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Feb 18, 2014 | Sale | $18.09 | 50,000 | 904,350 | 295,000 | Feb 19, 2014, 08:00 PM |
| RINGO WILLIAM R | Director | Feb 14, 2014 | Option Exercise | $5.64 | 25,000 | 141,050 | 25,800 | Feb 19, 2014, 08:00 PM |
| RINGO WILLIAM R | Director | Feb 14, 2014 | Sale | $18.06 | 25,000 | 451,575 | 800 | Feb 19, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Feb 10, 2014 | Option Exercise | $3.45 | 10,000 | 34,500 | 237,347 | Feb 12, 2014, 08:02 PM |
| Wolff Henry Ward | Exec VP & CFO | Feb 10, 2014 | Sale | $19.26 | 10,000 | 192,638 | 227,347 | Feb 12, 2014, 08:02 PM |
| Gregory Philip D | Vice President, Research & CSO | Feb 03, 2014 | Option Exercise | $3.76 | 15,000 | 56,370 | 124,347 | Feb 05, 2014, 08:00 PM |
| Gregory Philip D | Vice President, Research & CSO | Feb 03, 2014 | Sale | $18.83 | 15,000 | 282,516 | 109,347 | Feb 05, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jan 27, 2014 | Option Exercise | $3.68 | 15,000 | 55,230 | 110,015 | Jan 29, 2014, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jan 27, 2014 | Sale | $18.58 | 15,000 | 278,729 | 97,015 | Jan 29, 2014, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Jan 15, 2014 | Option Exercise | $6.39 | 50,000 | 319,500 | 345,000 | Jan 17, 2014, 08:01 PM |
| LANPHIER EDWARD O II | President & CEO | Jan 15, 2014 | Sale | $18.51 | 50,000 | 925,675 | 295,000 | Jan 17, 2014, 08:01 PM |
| Cleveland Paul B | Director | Jan 15, 2014 | Option Exercise | $5.03 | 8,333 | 41,915 | 8,333 | Jan 17, 2014, 08:00 PM |
| Cleveland Paul B | Director | Jan 15, 2014 | Sale | $18.68 | 8,333 | 155,694 | 0 | Jan 17, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Jan 10, 2014 | Option Exercise | $3.45 | 10,000 | 34,500 | 237,347 | Jan 14, 2014, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Jan 10, 2014 | Sale | $18.69 | 10,000 | 186,893 | 227,347 | Jan 14, 2014, 08:00 PM |
| Gregory Philip D | Vice President, Research & CSO | Jan 02, 2014 | Option Exercise | $3.76 | 15,000 | 56,370 | 124,347 | Jan 03, 2014, 08:38 PM |
| Gregory Philip D | Vice President, Research & CSO | Jan 02, 2014 | Sale | $13.56 | 15,000 | 203,340 | 109,347 | Jan 03, 2014, 08:38 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 26, 2013 | Option Exercise | $3.68 | 15,000 | 55,230 | 110,015 | Dec 30, 2013, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 26, 2013 | Sale | $14.37 | 15,000 | 215,477 | 97,015 | Dec 30, 2013, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Dec 18, 2013 | Option Exercise | $6.39 | 50,000 | 319,500 | 345,000 | Dec 20, 2013, 08:02 PM |
| LANPHIER EDWARD O II | President & CEO | Dec 18, 2013 | Sale | $12.47 | 50,000 | 623,705 | 295,000 | Dec 20, 2013, 08:02 PM |
| Gregory Philip D | Vice President, Research & CSO | Dec 12, 2013 | Option Exercise | $12.12 | 15,653 | 189,714 | 109,347 | Dec 13, 2013, 08:55 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 12, 2013 | Option Exercise | $12.12 | 14,783 | 179,170 | 97,015 | Dec 13, 2013, 08:03 PM |
| LANPHIER EDWARD O II | President & CEO | Dec 12, 2013 | Option Exercise | $12.12 | 57,398 | 695,664 | 347,602 | Dec 13, 2013, 07:59 PM |
| NICHOL GEOFFREY | Executive Vice President, R&D | Dec 12, 2013 | Option Exercise | $12.12 | 22,611 | 274,045 | 142,389 | Dec 13, 2013, 07:58 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 12, 2013 | Option Exercise | $12.12 | 20,872 | 252,969 | 227,347 | Dec 13, 2013, 07:58 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 10, 2013 | Option Exercise | $3.45 | 10,000 | 34,500 | 223,219 | Dec 12, 2013, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 10, 2013 | Sale | $11.97 | 10,000 | 119,670 | 213,219 | Dec 12, 2013, 08:00 PM |
| Gregory Philip D | Vice President, Research & CSO | Dec 02, 2013 | Option Exercise | $3.76 | 15,000 | 56,370 | 105,000 | Dec 04, 2013, 08:01 PM |
| Gregory Philip D | Vice President, Research & CSO | Dec 02, 2013 | Sale | $11.66 | 15,000 | 174,835 | 90,000 | Dec 04, 2013, 08:01 PM |
| Cleveland Paul B | Director | Dec 02, 2013 | Option Exercise | $6.41 | 10,000 | 64,100 | 10,000 | Dec 04, 2013, 08:00 PM |
| Cleveland Paul B | Director | Dec 02, 2013 | Sale | $11.64 | 10,000 | 116,393 | 0 | Dec 04, 2013, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Nov 26, 2013 | Option Exercise | $3.90 | 15,000 | 58,570 | 100,798 | Nov 29, 2013, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Nov 26, 2013 | Sale | $11.83 | 15,000 | 177,378 | 88,798 | Nov 29, 2013, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Nov 13, 2013 | Option Exercise | $3.45 | 10,000 | 34,500 | 223,219 | Nov 15, 2013, 08:01 PM |
| Wolff Henry Ward | Exec VP & CFO | Nov 13, 2013 | Sale | $10.00 | 10,000 | 100,000 | 213,219 | Nov 15, 2013, 08:01 PM |
| LANPHIER EDWARD O II | President & CEO | Nov 15, 2013 | Sale | $10.11 | 25,000 | 252,723 | 1,542,452 | Nov 15, 2013, 08:00 PM |
| Gregory Philip D | Vice President, Research & CSO | Nov 01, 2013 | Option Exercise | $3.45 | 8,000 | 27,600 | 98,000 | Nov 05, 2013, 08:02 PM |
| Gregory Philip D | Vice President, Research & CSO | Nov 05, 2013 | Option Exercise | $4.11 | 7,000 | 28,770 | 97,000 | Nov 05, 2013, 08:02 PM |
| Gregory Philip D | Vice President, Research & CSO | Nov 05, 2013 | Sale | $10.00 | 7,000 | 70,000 | 90,000 | Nov 05, 2013, 08:02 PM |
| Gregory Philip D | Vice President, Research & CSO | Nov 01, 2013 | Sale | $9.26 | 8,000 | 74,065 | 90,000 | Nov 05, 2013, 08:02 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Oct 28, 2013 | Option Exercise | $3.90 | 15,000 | 58,570 | 98,798 | Oct 30, 2013, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Oct 28, 2013 | Sale | $10.39 | 15,000 | 155,779 | 86,798 | Oct 30, 2013, 08:00 PM |
| Cleveland Paul B | Director | Oct 21, 2013 | Option Exercise | $4.54 | 10,000 | 45,400 | 10,000 | Oct 23, 2013, 09:01 PM |
| Cleveland Paul B | Director | Oct 21, 2013 | Sale | $10.93 | 10,000 | 109,336 | 0 | Oct 23, 2013, 09:01 PM |
| LANPHIER EDWARD O II | President & CEO | Oct 15, 2013 | Sale | $11.32 | 25,000 | 283,083 | 1,580,952 | Oct 17, 2013, 08:01 PM |
| Wolff Henry Ward | Exec VP & CFO | Oct 10, 2013 | Option Exercise | $3.45 | 10,000 | 34,500 | 219,219 | Oct 15, 2013, 08:02 PM |
| Wolff Henry Ward | Exec VP & CFO | Oct 10, 2013 | Sale | $11.28 | 10,000 | 112,763 | 209,219 | Oct 15, 2013, 08:02 PM |
| Gregory Philip D | Vice President, Research & CSO | Oct 01, 2013 | Option Exercise | $4.26 | 15,000 | 63,930 | 105,000 | Oct 04, 2013, 06:00 AM |
| Gregory Philip D | Vice President, Research & CSO | Oct 01, 2013 | Sale | $10.54 | 15,000 | 158,081 | 90,000 | Oct 04, 2013, 06:00 AM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Sep 26, 2013 | Option Exercise | $3.90 | 15,000 | 58,570 | 96,798 | Sep 30, 2013, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Sep 26, 2013 | Sale | $10.57 | 15,000 | 158,574 | 84,798 | Sep 30, 2013, 08:00 PM |
| LANPHIER EDWARD O II | President & CEO | Sep 16, 2013 | Sale | $11.29 | 25,000 | 282,127 | 1,605,952 | Sep 18, 2013, 09:45 PM |
| Wolff Henry Ward | Exec VP & CFO | Sep 10, 2013 | Option Exercise | $3.45 | 10,000 | 34,500 | 219,219 | Sep 12, 2013, 08:01 PM |
| Wolff Henry Ward | Exec VP & CFO | Sep 10, 2013 | Sale | $10.86 | 10,000 | 108,593 | 209,219 | Sep 12, 2013, 08:01 PM |
| Gregory Philip D | Vice President, Research & CSO | Sep 03, 2013 | Option Exercise | $4.26 | 15,000 | 63,930 | 105,000 | Sep 05, 2013, 08:02 PM |
| Gregory Philip D | Vice President, Research & CSO | Sep 03, 2013 | Sale | $10.33 | 15,000 | 154,981 | 90,000 | Sep 05, 2013, 08:02 PM |
| Cleveland Paul B | Director | Sep 03, 2013 | Option Exercise | $2.04 | 7,278 | 14,847 | 7,278 | Sep 05, 2013, 08:00 PM |
| Cleveland Paul B | Director | Sep 03, 2013 | Sale | $10.30 | 7,278 | 74,978 | 0 | Sep 05, 2013, 08:00 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Aug 26, 2013 | Option Exercise | $3.84 | 13,000 | 49,930 | 97,798 | Aug 28, 2013, 08:01 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Aug 26, 2013 | Sale | $10.04 | 15,000 | 150,606 | 86,798 | Aug 28, 2013, 08:01 PM |
| LANPHIER EDWARD O II | President & CEO | Aug 15, 2013 | Sale | $10.12 | 25,000 | 252,880 | 1,630,952 | Aug 16, 2013, 08:00 PM |
| Wolff Henry Ward | Exec VP & CFO | Aug 13, 2013 | Option Exercise | $3.45 | 10,000 | 34,500 | 219,219 | Aug 15, 2013, 08:01 PM |
| Wolff Henry Ward | Exec VP & CFO | Aug 13, 2013 | Sale | $10.00 | 10,000 | 100,000 | 209,219 | Aug 15, 2013, 08:01 PM |
| Gregory Philip D | Vice President, Research & CSO | Aug 01, 2013 | Option Exercise | $4.26 | 15,000 | 63,930 | 105,000 | Aug 05, 2013, 04:20 PM |
| Gregory Philip D | Vice President, Research & CSO | Aug 01, 2013 | Sale | $9.89 | 15,000 | 148,321 | 90,000 | Aug 05, 2013, 04:20 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jul 26, 2013 | Option Exercise | $3.84 | 13,000 | 49,930 | 99,798 | Jul 30, 2013, 04:20 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jul 26, 2013 | Sale | $10.09 | 15,000 | 151,308 | 88,798 | Jul 30, 2013, 04:20 PM |
| Gregory Philip D | Vice President, Research & CSO | Jul 29, 2013 | Option Exercise | $4.21 | 15,000 | 63,120 | 98,000 | Jul 30, 2013, 04:20 PM |
| Gregory Philip D | Vice President, Research & CSO | Jul 29, 2013 | Sale | $10.04 | 15,000 | 150,556 | 90,000 | Jul 30, 2013, 04:20 PM |
| LANPHIER EDWARD O II | President & CEO | Jul 17, 2013 | Sale | $10.00 | 25,000 | 250,003 | 1,655,952 | Jul 19, 2013, 06:13 PM |
| Wolff Henry Ward | Exec VP & CFO | Jul 17, 2013 | Option Exercise | $3.45 | 10,000 | 34,500 | 219,219 | Jul 19, 2013, 06:07 PM |
| Wolff Henry Ward | Exec VP & CFO | Jul 17, 2013 | Sale | $10.00 | 10,000 | 100,000 | 209,219 | Jul 19, 2013, 06:07 PM |
| Cleveland Paul B | Director | Jul 15, 2013 | Option Exercise | $2.04 | 8,000 | 16,320 | 8,000 | Jul 17, 2013, 04:30 PM |
| Cleveland Paul B | Director | Jul 15, 2013 | Sale | $9.59 | 8,000 | 76,718 | 0 | Jul 17, 2013, 04:30 PM |
| Gregory Philip D | Vice President, Research & CSO | Jun 03, 2013 | Option Exercise | $3.45 | 3,000 | 10,350 | 93,000 | Jun 05, 2013, 04:30 PM |
| Gregory Philip D | Vice President, Research & CSO | Jun 03, 2013 | Sale | $7.88 | 3,000 | 23,640 | 90,000 | Jun 05, 2013, 04:30 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | May 28, 2013 | Option Exercise | $3.61 | 15,000 | 54,150 | 103,798 | May 30, 2013, 04:31 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | May 28, 2013 | Sale | $8.32 | 15,000 | 124,818 | 88,798 | May 30, 2013, 04:31 PM |
| LARSON JOHN WILLIAM | Director | May 07, 2013 | Option Exercise | $2.45 | 10,000 | 24,500 | 218,160 | May 09, 2013, 04:50 PM |
| Gregory Philip D | Vice President, Research & CSO | May 01, 2013 | Option Exercise | $3.45 | 6,000 | 20,700 | 96,000 | May 03, 2013, 05:36 PM |
| Gregory Philip D | Vice President, Research & CSO | May 01, 2013 | Sale | $10.09 | 6,000 | 60,557 | 90,000 | May 03, 2013, 05:36 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Apr 26, 2013 | Option Exercise | $3.61 | 15,000 | 54,150 | 103,798 | Apr 29, 2013, 06:16 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Apr 26, 2013 | Sale | $10.72 | 15,000 | 160,746 | 88,798 | Apr 29, 2013, 06:16 PM |
| LANPHIER EDWARD O II | President & CEO | Apr 16, 2013 | Sale | $10.00 | 190 | 1,900 | 1,692,952 | Apr 19, 2013, 06:00 AM |
| LANPHIER EDWARD O II | President & CEO | Apr 15, 2013 | Sale | $10.00 | 5,000 | 50,000 | 1,693,142 | Apr 19, 2013, 06:00 AM |
| Wolff Henry Ward | Exec VP & CFO | Apr 10, 2013 | Option Exercise | $3.45 | 10,000 | 34,500 | 219,219 | Apr 12, 2013, 04:30 PM |
| Wolff Henry Ward | Exec VP & CFO | Apr 10, 2013 | Sale | $10.00 | 10,000 | 100,000 | 209,219 | Apr 12, 2013, 04:30 PM |
| Gregory Philip D | Vice President, Research & CSO | Apr 01, 2013 | Option Exercise | $3.45 | 6,000 | 20,700 | 96,000 | Apr 03, 2013, 06:06 PM |
| Gregory Philip D | Vice President, Research & CSO | Apr 01, 2013 | Sale | $9.54 | 6,000 | 57,240 | 90,000 | Apr 03, 2013, 06:06 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Mar 26, 2013 | Option Exercise | $3.61 | 15,000 | 54,150 | 103,798 | Mar 28, 2013, 05:44 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Mar 26, 2013 | Sale | $9.18 | 15,000 | 137,724 | 88,798 | Mar 28, 2013, 05:44 PM |
| Gregory Philip D | Vice President, Research & CSO | Mar 01, 2013 | Option Exercise | $4.92 | 6,000 | 29,520 | 96,000 | Mar 01, 2013, 06:36 PM |
| Gregory Philip D | Vice President, Research & CSO | Mar 01, 2013 | Sale | $10.00 | 6,000 | 60,005 | 90,000 | Mar 01, 2013, 06:36 PM |
| Wolff Henry Ward | Exec VP & CFO | Feb 28, 2013 | Option Exercise | $3.45 | 10,000 | 34,500 | 219,219 | Mar 01, 2013, 06:34 PM |
| Wolff Henry Ward | Exec VP & CFO | Feb 28, 2013 | Sale | $10.00 | 10,000 | 100,000 | 209,219 | Mar 01, 2013, 06:34 PM |
| LANPHIER EDWARD O II | President & CEO | Feb 28, 2013 | Sale | $10.00 | 25,000 | 250,000 | 1,698,142 | Mar 01, 2013, 06:32 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Feb 26, 2013 | Option Exercise | $3.61 | 15,000 | 54,150 | 103,798 | Feb 28, 2013, 06:15 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Feb 26, 2013 | Sale | $8.64 | 15,000 | 129,600 | 88,798 | Feb 28, 2013, 06:15 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jan 28, 2013 | Option Exercise | $3.61 | 15,000 | 54,150 | 103,798 | Feb 28, 2013, 06:11 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jan 28, 2013 | Sale | $9.68 | 15,000 | 145,158 | 88,798 | Feb 28, 2013, 06:11 PM |
| Gregory Philip D | Vice President, Research & CSO | Feb 01, 2013 | Option Exercise | $4.92 | 6,000 | 29,520 | 96,000 | Feb 05, 2013, 04:15 PM |
| Gregory Philip D | Vice President, Research & CSO | Feb 01, 2013 | Sale | $9.53 | 6,000 | 57,195 | 90,000 | Feb 05, 2013, 04:15 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jan 28, 2012 | Option Exercise | $3.61 | 15,000 | 54,150 | 103,798 | Jan 30, 2013, 04:17 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jan 28, 2012 | Sale | $9.68 | 15,000 | 145,158 | 88,798 | Jan 30, 2013, 04:17 PM |
| Wolff Henry Ward | Exec VP & CFO | Jan 23, 2013 | Option Exercise | $3.45 | 8,000 | 27,600 | 219,219 | Jan 28, 2013, 06:01 AM |
| Wolff Henry Ward | Exec VP & CFO | Jan 23, 2013 | Sale | $10.00 | 10,000 | 100,000 | 209,219 | Jan 28, 2013, 06:01 AM |
| LANPHIER EDWARD O II | President & CEO | Jan 23, 2013 | Sale | $10.00 | 8,300 | 83,008 | 1,723,442 | Jan 28, 2013, 06:01 AM |
| LANPHIER EDWARD O II | President & CEO | Jan 24, 2013 | Sale | $10.00 | 300 | 3,000 | 1,723,142 | Jan 28, 2013, 06:01 AM |
| Gregory Philip D | Vice President, Research & CSO | Jan 02, 2013 | Option Exercise | $4.92 | 6,000 | 29,520 | 96,000 | Jan 04, 2013, 06:14 PM |
| Gregory Philip D | Vice President, Research & CSO | Jan 02, 2013 | Sale | $6.05 | 6,000 | 36,300 | 90,000 | Jan 04, 2013, 06:14 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 26, 2012 | Option Exercise | $3.61 | 15,000 | 54,150 | 103,798 | Dec 28, 2012, 04:06 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Dec 26, 2012 | Sale | $5.92 | 17,000 | 100,718 | 88,798 | Dec 28, 2012, 04:06 PM |
| Gregory Philip D | Vice President, Research & CSO | Dec 10, 2012 | Sale | $5.46 | 24,000 | 131,040 | 102,000 | Dec 10, 2012, 08:40 PM |
| LARSON JOHN WILLIAM | Director | Dec 03, 2012 | Sale | $5.64 | 15,000 | 84,634 | 222,160 | Dec 05, 2012, 06:06 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Nov 27, 2012 | Option Exercise | $3.61 | 15,000 | 54,150 | 70,798 | Nov 28, 2012, 07:35 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Nov 26, 2012 | Sale | $5.33 | 4,736 | 25,232 | 55,798 | Nov 28, 2012, 07:35 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Nov 27, 2012 | Sale | $5.60 | 15,000 | 84,000 | 55,798 | Nov 28, 2012, 07:35 PM |
| LARSON JOHN WILLIAM | Director | Nov 01, 2012 | Sale | $5.52 | 15,000 | 82,764 | 223,160 | Nov 05, 2012, 06:15 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Oct 26, 2012 | Option Exercise | $3.61 | 15,000 | 54,150 | 78,534 | Oct 29, 2012, 09:53 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Oct 26, 2012 | Sale | $5.70 | 20,000 | 113,935 | 63,534 | Oct 29, 2012, 09:53 PM |
| Gregory Philip D | VP, Therapeutic Dev. & CMO | Oct 17, 2012 | Option Exercise | $4.92 | 6,000 | 29,520 | 56,000 | Oct 17, 2012, 09:05 PM |
| Gregory Philip D | VP, Therapeutic Dev. & CMO | Oct 17, 2012 | Sale | $6.00 | 6,000 | 36,000 | 50,000 | Oct 17, 2012, 09:05 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Oct 15, 2012 | Sale | $5.66 | 5,000 | 28,283 | 67,534 | Oct 17, 2012, 05:58 PM |
| LARSON JOHN WILLIAM | Director | Oct 01, 2012 | Sale | $6.20 | 15,000 | 93,035 | 252,860 | Oct 03, 2012, 05:51 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Sep 05, 2012 | Option Exercise | $3.61 | 15,000 | 54,150 | 83,534 | Sep 06, 2012, 05:51 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Sep 05, 2012 | Sale | $5.60 | 15,000 | 84,000 | 68,534 | Sep 06, 2012, 05:51 PM |
| LARSON JOHN WILLIAM | Director | Sep 04, 2012 | Sale | $5.30 | 15,000 | 79,494 | 268,060 | Sep 06, 2012, 05:46 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Aug 27, 2012 | Sale | $5.18 | 5,000 | 25,903 | 72,364 | Aug 29, 2012, 07:07 PM |
| LARSON JOHN WILLIAM | Director | Aug 01, 2012 | Sale | $5.25 | 15,000 | 78,825 | 282,460 | Aug 03, 2012, 05:27 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jul 27, 2012 | Option Exercise | $3.61 | 15,000 | 54,150 | 88,534 | Jul 30, 2012, 04:58 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jul 27, 2012 | Sale | $5.60 | 15,000 | 84,000 | 73,534 | Jul 30, 2012, 04:58 PM |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | Jul 26, 2012 | Sale | $5.06 | 5,000 | 25,320 | 77,534 | Jul 30, 2012, 04:58 PM |
| LARSON JOHN WILLIAM | Director | Jul 02, 2012 | Sale | $5.24 | 15,000 | 78,556 | 296,619 | Jul 03, 2012, 04:02 PM |
| LARSON JOHN WILLIAM | Director | Jun 15, 2012 | Sale | $5.00 | 15,000 | 75,000 | 298,160 | Jun 19, 2012, 05:18 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 30, 2011 | Option Exercise | $2.84 | 2,234 | 6,345 | 162,219 | Jan 04, 2012, 06:08 PM |
| Wolff Henry Ward | Exec VP & CFO | Sep 30, 2011 | Option Exercise | $4.35 | 2,234 | 9,718 | 87,453 | Oct 04, 2011, 04:48 PM |
| Gregory Philip D | CSO & Vice President, Research | Sep 09, 2011 | Option Exercise | $3.45 | 2,500 | 8,625 | 2,500 | Sep 14, 2011, 07:18 PM |
| Gregory Philip D | CSO & Vice President, Research | Sep 09, 2011 | Option Exercise | $3.00 | 2,500 | 7,500 | 2,500 | Sep 13, 2011, 08:48 PM |
| Gregory Philip D | CSO & Vice President, Research | Sep 09, 2011 | Sale | $6.00 | 2,500 | 15,000 | 0 | Sep 13, 2011, 08:48 PM |
| Ichikawa David G | Senior VP, Bus. Dev. | Jul 07, 2011 | Option Exercise | $5.19 | 4,000 | 20,760 | 4,000 | Jul 11, 2011, 08:04 PM |
| Ichikawa David G | Senior VP, Bus. Dev. | Jul 07, 2011 | Sale | $6.47 | 4,000 | 25,880 | 0 | Jul 11, 2011, 08:04 PM |
| Wolff Henry Ward | Exec VP & CFO | Jun 30, 2011 | Option Exercise | $5.89 | 2,234 | 13,158 | 89,687 | Jul 05, 2011, 05:17 PM |
| Gregory Philip D | CSO & Vice President, Research | Jul 01, 2011 | Option Exercise | $3.45 | 15,000 | 51,750 | 15,000 | Jul 05, 2011, 05:15 PM |
| Gregory Philip D | CSO & Vice President, Research | Jul 01, 2011 | Sale | $6.00 | 15,000 | 90,000 | 0 | Jul 05, 2011, 05:15 PM |
| Ichikawa David G | Senior VP, Bus. Dev. | Jun 06, 2011 | Option Exercise | $5.19 | 4,000 | 20,760 | 4,000 | Jun 08, 2011, 06:05 PM |
| Ichikawa David G | Senior VP, Bus. Dev. | Jun 06, 2011 | Sale | $6.52 | 4,000 | 26,080 | 0 | Jun 08, 2011, 06:05 PM |
| Gregory Philip D | CSO & Vice President, Research | Jun 01, 2011 | Option Exercise | $3.45 | 15,000 | 51,750 | 15,000 | Jun 03, 2011, 05:32 PM |
| Gregory Philip D | CSO & Vice President, Research | Jun 01, 2011 | Sale | $6.80 | 15,000 | 102,012 | 14,894 | Jun 03, 2011, 05:32 PM |
| Ichikawa David G | Senior VP, Bus. Dev. | May 05, 2011 | Option Exercise | $5.19 | 4,000 | 20,760 | 4,000 | May 09, 2011, 05:20 PM |
| Ichikawa David G | Senior VP, Bus. Dev. | May 05, 2011 | Sale | $6.74 | 4,000 | 26,960 | 0 | May 09, 2011, 05:20 PM |
| Gregory Philip D | CSO & Vice President, Research | May 02, 2011 | Option Exercise | $3.45 | 15,000 | 51,750 | 15,000 | May 04, 2011, 05:57 PM |
| Gregory Philip D | CSO & Vice President, Research | May 02, 2011 | Sale | $7.33 | 15,000 | 109,930 | 13,500 | May 04, 2011, 05:57 PM |
| Gregory Philip D | CSO & Vice President, Research | Apr 25, 2011 | Option Exercise | $3.32 | 15,000 | 49,856 | 19,433 | Apr 27, 2011, 07:10 PM |
| Gregory Philip D | CSO & Vice President, Research | Apr 25, 2011 | Sale | $7.54 | 19,433 | 146,508 | 17,785 | Apr 27, 2011, 07:10 PM |
| Ichikawa David G | Senior VP, Bus. Dev. | Apr 21, 2011 | Option Exercise | $5.19 | 8,000 | 41,520 | 8,000 | Apr 25, 2011, 05:32 PM |
| Ichikawa David G | Senior VP, Bus. Dev. | Apr 21, 2011 | Sale | $7.70 | 8,000 | 61,625 | 7,900 | Apr 25, 2011, 05:32 PM |
| Wolff Henry Ward | Exec VP & CFO | Mar 31, 2011 | Option Exercise | $8.33 | 2,235 | 18,618 | 89,921 | Apr 04, 2011, 05:34 PM |
| Cleveland Paul B | Director | Feb 28, 2011 | Option Exercise | $2.04 | 1,388 | 2,832 | 1,388 | Mar 02, 2011, 06:46 PM |
| Cleveland Paul B | Director | Feb 28, 2011 | Sale | $9.00 | 1,388 | 12,492 | 0 | Mar 02, 2011, 06:46 PM |
| Gregory Philip D | CSO & Vice President, Research | Mar 01, 2011 | Sale | $8.29 | 2,500 | 20,715 | 6,893 | Mar 02, 2011, 06:45 PM |
| Gregory Philip D | CSO & Vice President, Research | Feb 28, 2011 | Sale | $9.00 | 2,500 | 22,500 | 6,933 | Mar 02, 2011, 06:45 PM |
| Gregory Philip D | CSO & Vice President, Research | Feb 01, 2011 | Sale | $7.97 | 2,500 | 19,925 | 11,633 | Feb 03, 2011, 05:14 PM |
| Gregory Philip D | CSO & Vice President, Research | Jan 03, 2011 | Sale | $6.80 | 2,500 | 17,000 | 11,933 | Jan 05, 2011, 04:42 PM |
| Wolff Henry Ward | Exec VP & CFO | Dec 31, 2010 | Option Exercise | $6.64 | 2,234 | 14,834 | 92,156 | Jan 04, 2011, 04:36 PM |
| Cleveland Paul B | Director | Dec 22, 2010 | Option Exercise | $2.68 | 32,037 | 85,955 | 32,037 | Dec 23, 2010, 07:52 PM |
| Cleveland Paul B | Director | Dec 22, 2010 | Sale | $7.00 | 32,037 | 224,259 | 10,000 | Dec 23, 2010, 07:52 PM |
| Cleveland Paul B | Director | Dec 20, 2010 | Option Exercise | $2.04 | 11,297 | 23,046 | 11,297 | Dec 22, 2010, 05:27 PM |
| Cleveland Paul B | Director | Dec 20, 2010 | Sale | $7.00 | 11,297 | 79,079 | 0 | Dec 22, 2010, 05:27 PM |
| Gregory Philip D | CSO & Vice President, Research | Dec 08, 2010 | Sale | $6.00 | 2,500 | 15,000 | 12,433 | Dec 10, 2010, 05:04 PM |
| Wolff Henry Ward | Exec VP & CFO | Sep 30, 2010 | Option Exercise | $3.43 | 2,239 | 7,680 | 92,390 | Oct 04, 2010, 04:15 PM |
| LANPHIER EDWARD O II | President & CEO | Aug 30, 2010 | Buy | $3.01 | 10,000 | 30,050 | 1,661,242 | Aug 30, 2010, 06:09 PM |
| Wolff Henry Ward | Exec VP & CFO | Aug 30, 2010 | Buy | $3.00 | 9,000 | 27,000 | 94,629 | Aug 30, 2010, 06:09 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Pooler Amy | VP, HEAD OF RESEARCH | 02/25/2024 | 2,779 |
| Pooler Amy | VP, HEAD OF RESEARCH | 02/24/2024 | 2,496 |
| Willoughby Scott B. | SVP, GEN. COUNSEL & SECRETARY | 02/25/2024 | 3,902 |
| Willoughby Scott B. | SVP, GEN. COUNSEL & SECRETARY | 02/24/2024 | 4,948 |
| Dubois-Stringfellow Nathalie | SVP-CHIEF DEVELOPMENT OFFICER | 02/25/2024 | 5,661 |
| Dubois-Stringfellow Nathalie | SVP-CHIEF DEVELOPMENT OFFICER | 02/24/2024 | 6,186 |
| Duraibabu Prathyusha | SVP, CHIEF FINANCIAL OFFICER | 02/25/2024 | 3,902 |
| Duraibabu Prathyusha | SVP, CHIEF FINANCIAL OFFICER | 02/24/2024 | 6,186 |
| Macrae Sandy | PRESIDENT, CEO AND DIRECTOR | 02/25/2024 | 27,297 |
| Macrae Sandy | PRESIDENT, CEO AND DIRECTOR | 02/24/2024 | 18,210 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 11/25/2023 | 508 |
| McClung David Mark | EVP, Chief Operating Officer | 11/25/2023 | 736 |
| Macrae Sandy | President, CEO and Director | 11/25/2023 | 3,978 |
| Fontenot Jason D. | SVP, Chief Scientific Officer | 11/25/2023 | 394 |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | 11/25/2023 | 508 |
| Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | 11/25/2023 | 559 |
| Pooler Amy | VP, Head of Research | 11/25/2023 | 187 |
| BIOGEN INC. | 10% Owner | 09/26/2023 | 3,000,000 |
| Fontenot Jason D. | SVP, Chief Scientific Officer | 08/25/2023 | 792 |
| McClung David Mark | EVP, Chief Operating Officer | 08/25/2023 | 1,482 |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | 08/25/2023 | 1,023 |
| Macrae Sandy | President, CEO and Director | 08/25/2023 | 8,016 |
| Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | 08/25/2023 | 1,126 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 08/25/2023 | 1,023 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 08/13/2023 | 933 |
| McClung David Mark | EVP, Chief Operating Officer | 06/25/2023 | 13,718 |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | 06/11/2023 | 1,028 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 05/25/2023 | 1,766 |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | 05/25/2023 | 2,328 |
| McClung David Mark | EVP, Chief Operating Officer | 05/25/2023 | 2,560 |
| Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | 05/25/2023 | 1,944 |
| Fontenot Jason D. | SVP, Chief Scientific Officer | 05/25/2023 | 1,369 |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | 05/25/2023 | 1,766 |
| Macrae Sandy | President, CEO and Director | 05/25/2023 | 13,847 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 04/24/2023 | 6,562 |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | 03/25/2023 | 573 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 02/25/2023 | 13,640 |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | 02/25/2023 | 41,544 |
| McClung David Mark | EVP, Chief Operating Officer | 02/25/2023 | 25,922 |
| Dubois-Stringfellow Nathalie | SVP-Chief Development Officer | 02/25/2023 | 26,158 |
| Fontenot Jason D. | SVP, Chief Scientific Officer | 02/25/2023 | 17,447 |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | 02/25/2023 | 18,700 |
| Macrae Sandy | President, CEO and Director | 02/25/2023 | 145,680 |
| Duraibabu Prathyusha | SVP, Chief Financial Officer | 06/11/2022 | 3,249 |
| BIOGEN INC. | 10% Owner | 08/30/2022 | 526,520 |
| BIOGEN INC. | 10% Owner | 08/29/2022 | 2,130,720 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 08/13/2022 | 5,469 |
| McClung David Mark | EVP, Chief Operating Officer | 06/25/2022 | 49,673 |
| Duraibabu Prathyusha | Vice President, Finance | 06/11/2022 | 3,166 |
| Markels John | Director | 06/03/2022 | 25,029 |
| PARKER H STEWART | Director | 06/01/2022 | 17,996 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 04/29/2022 | 581 |
| Fontenot Jason D. | SVP, Chief Scientific Officer | 04/25/2022 | 3,990 |
| Duraibabu Prathyusha | Vice President, Finance | 04/25/2022 | 3,197 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 04/24/2022 | 18,687 |
| Duraibabu Prathyusha | Vice President, Finance | 03/25/2022 | 1,984 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 02/25/2022 | 9,239 |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | 02/25/2022 | 73,089 |
| Fontenot Jason D. | SVP, Chief Scientific Officer | 02/25/2022 | 36,863 |
| Duraibabu Prathyusha | Vice President, Finance | 02/25/2022 | 20,497 |
| McClung David Mark | EVP, Chief Operating Officer | 02/25/2022 | 27,199 |
| Macrae Sandy | President, CEO and Director | 02/25/2022 | 294,351 |
| Schott Robert J. | SVP, Head of Development | 02/12/2022 | 31,467 |
| BIOGEN INC. | 10% Owner | 12/28/2021 | 23,522 |
| BIOGEN INC. | 10% Owner | 12/27/2021 | 5,136 |
| BIOGEN INC. | 10% Owner | 12/23/2021 | 694,530 |
| BIOGEN INC. | 10% Owner | 12/09/2021 | 202,541 |
| BIOGEN INC. | 10% Owner | 12/08/2021 | 654,828 |
| BIOGEN INC. | 10% Owner | 12/07/2021 | 444,437 |
| BIOGEN INC. | 10% Owner | 12/02/2021 | 15,943 |
| BIOGEN INC. | 10% Owner | 12/01/2021 | 6,223 |
| BIOGEN INC. | 10% Owner | 11/26/2021 | 248,434 |
| Willoughby Scott B. | SVP, Gen. Counsel & Secretary | 10/29/2021 | 1,137 |
| McClung David Mark | EVP, Chief Business Officer | 06/25/2021 | 138,531 |
| Fontenot Jason D. | SVP, Chief Scientific Officer | 04/25/2021 | 9,497 |
| Duraibabu Prathyusha | VP, PFO and PAO | 04/25/2021 | 7,752 |
| Duraibabu Prathyusha | VP, PFO and PAO | 03/25/2021 | 4,233 |
| LOEB GARY | EVP, General Counsel & Sec. | 03/23/2021 | 132,031 |
| LOEB GARY | EVP, General Counsel & Sec. | 03/23/2021 | 230,042 |
| Duraibabu Prathyusha | VP Principal Acct. Officer | 02/25/2021 | 20,847 |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | 02/25/2021 | 87,047 |
| LOEB GARY | EVP, General Counsel & Sec. | 02/25/2021 | 64,477 |
| Macrae Sandy | President and CEO | 02/25/2021 | 395,130 |
| Macrae Sandy | President and CEO | 01/24/2021 | 59,456 |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | 12/31/2020 | 41,247 |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | 12/24/2020 | 60,391 |
| Ramasastry Saira | Director | 12/17/2020 | 59,900 |
| Ramasastry Saira | Director | 12/17/2020 | 132,747 |
| Lee Sung | EVP, Chief Financial Officer | 11/25/2020 | 49,260 |
| Boissel Stephane | EVP, Corp. Strategy | 06/04/2020 | 167,406 |
| Duraibabu Prathyusha | VP Principal Acct. Officer | 04/25/2020 | 5,383 |
| DILLY STEPHEN GEORGE | Director | 03/19/2020 | 189,700 |
| DILLY STEPHEN GEORGE | Director | 03/19/2020 | 210,000 |
| PARKER H STEWART | Director | 03/18/2020 | 15,585 |
| Zakrzewski Joseph S | Director | 03/17/2020 | 24,950 |
| DILLY STEPHEN GEORGE | Director | 03/16/2020 | 81,300 |
| DILLY STEPHEN GEORGE | Director | 03/16/2020 | 90,261 |
| Zakrzewski Joseph S | Director | 03/13/2020 | 28,350 |
| Zakrzewski Joseph S | Director | 03/12/2020 | 94,650 |
| Ramelmeier Rolf Andrew | EVP, Technical Operations | 02/25/2020 | 11,580 |
| Boissel Stephane | EVP, Corp. Strategy | 02/25/2020 | 16,211 |
| Macrae Sandy | President and CEO | 02/25/2020 | 49,395 |
| Macrae Sandy | President and CEO | 01/24/2020 | 32,123 |
| Boissel Stephane | EVP, Corp. Strat. & Int. CFO | 08/12/2019 | 125,069 |
| Yi Kathy | EVP & Chief Financial Officer | 05/15/2019 | 22,750 |
| Yi Kathy | EVP & Chief Financial Officer | 05/15/2019 | 50,000 |
| Yi Kathy | EVP & Chief Financial Officer | 04/15/2019 | 22,750 |
| Yi Kathy | EVP & Chief Financial Officer | 04/15/2019 | 60,550 |
| Yi Kathy | EVP & Chief Financial Officer | 03/15/2019 | 22,750 |
| Yi Kathy | EVP & Chief Financial Officer | 03/15/2019 | 50,000 |
| Yi Kathy | EVP & Chief Financial Officer | 03/01/2019 | 22,750 |
| Yi Kathy | EVP & Chief Financial Officer | 03/01/2019 | 50,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 01/24/2019 | 9,257 |
| Yi Kathy | SVP & Chief Financial Officer | 01/24/2019 | 10,967 |
| Macrae Sandy | President and CEO | 01/24/2018 | 44,111 |
| Yi Kathy | SVP & Chief Financial Officer | 01/15/2019 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 01/15/2019 | 55,200 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 01/07/2019 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 01/07/2019 | 61,631 |
| Yi Kathy | SVP & Chief Financial Officer | 12/17/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 12/17/2018 | 57,200 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 12/06/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 12/06/2018 | 57,433 |
| Yi Kathy | SVP & Chief Financial Officer | 11/15/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 11/15/2018 | 50,000 |
| PARKER H STEWART | Director | 11/14/2018 | 18,002 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 11/06/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 11/06/2018 | 68,650 |
| Yi Kathy | SVP & Chief Financial Officer | 10/15/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 10/15/2018 | 69,850 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 10/08/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 10/08/2018 | 72,773 |
| Yi Kathy | SVP & Chief Financial Officer | 09/17/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 09/17/2018 | 73,285 |
| JEFFS ROGER | Director | 09/07/2018 | 100,487 |
| PARKER H STEWART | Director | 09/07/2018 | 27,040 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 09/06/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 09/06/2018 | 70,845 |
| Yi Kathy | SVP & Chief Financial Officer | 08/16/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 08/16/2018 | 76,951 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 08/06/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 08/06/2018 | 67,250 |
| Yi Kathy | SVP & Chief Financial Officer | 07/16/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 07/16/2018 | 73,860 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 07/06/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 07/06/2018 | 78,975 |
| Yi Kathy | SVP & Chief Financial Officer | 06/15/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 06/15/2018 | 78,365 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 06/06/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 06/06/2018 | 83,350 |
| Yi Kathy | SVP & Chief Financial Officer | 05/15/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 05/15/2018 | 76,920 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 05/07/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 05/07/2018 | 81,814 |
| Yi Kathy | SVP & Chief Financial Officer | 04/16/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 04/16/2018 | 99,144 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 04/13/2018 | 114,853 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 04/13/2018 | 163,260 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 04/06/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 04/06/2018 | 87,065 |
| Mento Steven J | Director | 04/02/2018 | 77,700 |
| Mento Steven J | Director | 04/02/2018 | 132,758 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 04/02/2018 | 12,199 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 04/02/2018 | 41,684 |
| Yi Kathy | SVP & Chief Financial Officer | 03/15/2018 | 22,750 |
| Yi Kathy | SVP & Chief Financial Officer | 03/15/2018 | 127,812 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 03/06/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 03/06/2018 | 123,877 |
| Mento Steven J | Director | 03/01/2018 | 82,350 |
| Mento Steven J | Director | 03/01/2018 | 219,546 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 03/01/2018 | 147,905 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 03/01/2018 | 345,861 |
| Ramasastry Saira | Director | 02/26/2018 | 47,534 |
| Ramasastry Saira | Director | 02/26/2018 | 235,080 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 02/06/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 02/06/2018 | 92,436 |
| Mento Steven J | Director | 02/01/2018 | 133,750 |
| Mento Steven J | Director | 02/01/2018 | 237,159 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 02/01/2018 | 52,500 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 02/01/2018 | 308,854 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 01/08/2018 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 01/08/2018 | 85,545 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 01/02/2018 | 9,212 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 01/03/2018 | 97,275 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 01/02/2018 | 114,025 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 01/03/2018 | 144,869 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 12/11/2017 | 19,844 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 12/08/2017 | 39,681 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 12/06/2017 | 16,000 |
| Conner Edward R. | Sr. VP & Chief Medical Officer | 12/06/2017 | 81,200 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 12/04/2017 | 143,052 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 12/04/2017 | 212,454 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 12/01/2017 | 11,039 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 11/30/2017 | 126,405 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 12/01/2017 | 53,390 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 11/30/2017 | 214,928 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 12/01/2017 | 11,039 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 11/30/2017 | 126,405 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 12/01/2017 | 53,390 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 11/30/2017 | 214,928 |
| Ramasastry Saira | Director | 11/17/2017 | 25,150 |
| Ramasastry Saira | Director | 11/17/2017 | 73,339 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 10/02/2017 | 114,905 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 10/02/2017 | 228,754 |
| RINGO WILLIAM R | Director | 09/20/2017 | 187,550 |
| RINGO WILLIAM R | Director | 09/20/2017 | 445,597 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 09/01/2017 | 55,810 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 09/01/2017 | 225,000 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 08/14/2017 | 25,600 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 08/11/2017 | 21,511 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 08/11/2017 | 64,740 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 08/14/2017 | 55,000 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 07/14/2017 | 686 |
| Herberts Curt A. III | Sr.VP & Chief Business Officer | 07/14/2017 | 150,000 |
| Herberts Curt A. III | Senior VP & CBO | 06/01/2017 | 13,600 |
| Herberts Curt A. III | Senior VP & CBO | 05/11/2017 | 4,154 |
| Herberts Curt A. III | Senior VP & CBO | 05/12/2017 | 17,000 |
| Herberts Curt A. III | Senior VP & CBO | 12/12/2016 | 14,799 |
| Wolff Henry Ward | Exec VP & CFO | 12/12/2015 | 42,023 |
| LANPHIER EDWARD O II | Director | 06/13/2016 | 527,320 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/12/2015 | 34,720 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/11/2015 | 37,741 |
| LANPHIER EDWARD O II | President & CEO | 12/12/2015 | 113,231 |
| LANPHIER EDWARD O II | President & CEO | 12/11/2015 | 188,712 |
| NICHOL GEOFFREY | Executive Vice President, R&D | 12/12/2015 | 38,053 |
| NICHOL GEOFFREY | Executive Vice President, R&D | 12/11/2015 | 40,770 |
| Wolff Henry Ward | Exec VP & CFO | 12/12/2015 | 52,835 |
| Wolff Henry Ward | Exec VP & CFO | 12/11/2015 | 56,611 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/07/2015 | 58,983 |
| LANPHIER EDWARD O II | President & CEO | 12/07/2015 | 303,375 |
| NICHOL GEOFFREY | Executive Vice President, R&D | 12/07/2015 | 66,754 |
| Wolff Henry Ward | Exec VP & CFO | 12/07/2015 | 68,411 |
| LANPHIER EDWARD O II | President & CEO | 07/15/2015 | 170,500 |
| LANPHIER EDWARD O II | President & CEO | 07/15/2015 | 260,770 |
| Wolff Henry Ward | Exec VP & CFO | 07/13/2015 | 13,448 |
| Wolff Henry Ward | Exec VP & CFO | 07/10/2015 | 21,052 |
| Wolff Henry Ward | Exec VP & CFO | 07/13/2015 | 58,980 |
| Wolff Henry Ward | Exec VP & CFO | 07/10/2015 | 61,020 |
| LANPHIER EDWARD O II | President & CEO | 06/15/2015 | 170,500 |
| LANPHIER EDWARD O II | President & CEO | 06/15/2015 | 277,078 |
| Wolff Henry Ward | Exec VP & CFO | 06/10/2015 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 06/10/2015 | 146,558 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 06/05/2015 | 51,750 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 06/05/2015 | 184,394 |
| RINGO WILLIAM R | Director | 06/03/2015 | 13,310 |
| RINGO WILLIAM R | Director | 06/03/2015 | 27,364 |
| Gregory Philip D | SVP of Research & CSO | 06/01/2015 | 77,000 |
| Gregory Philip D | SVP of Research & CSO | 06/01/2015 | 185,816 |
| LANPHIER EDWARD O II | President & CEO | 05/15/2015 | 170,500 |
| LANPHIER EDWARD O II | President & CEO | 05/15/2015 | 287,862 |
| Wolff Henry Ward | Exec VP & CFO | 05/11/2015 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 05/11/2015 | 158,949 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 05/05/2015 | 51,750 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 05/05/2015 | 184,297 |
| RINGO WILLIAM R | Director | 05/04/2015 | 18,582 |
| RINGO WILLIAM R | Director | 05/04/2015 | 38,927 |
| Gregory Philip D | SVP of Research & CSO | 05/01/2015 | 77,000 |
| Gregory Philip D | SVP of Research & CSO | 05/01/2015 | 189,370 |
| LANPHIER EDWARD O II | President & CEO | 04/15/2015 | 170,500 |
| LANPHIER EDWARD O II | President & CEO | 04/15/2015 | 383,260 |
| Wolff Henry Ward | Exec VP & CFO | 04/10/2015 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 04/10/2015 | 183,771 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 04/06/2015 | 51,750 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 04/06/2015 | 224,172 |
| RINGO WILLIAM R | Director | 04/06/2015 | 14,102 |
| RINGO WILLIAM R | Director | 04/06/2015 | 32,881 |
| Gregory Philip D | SVP of Research & CSO | 04/01/2015 | 77,000 |
| Gregory Philip D | SVP of Research & CSO | 04/01/2015 | 227,192 |
| Wolff Henry Ward | Exec VP & CFO | 03/19/2015 | 142,700 |
| Wolff Henry Ward | Exec VP & CFO | 03/19/2015 | 180,000 |
| LANPHIER EDWARD O II | President & CEO | 03/16/2015 | 170,500 |
| LANPHIER EDWARD O II | President & CEO | 03/16/2015 | 432,305 |
| Wolff Henry Ward | Exec VP & CFO | 03/10/2015 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 03/10/2015 | 200,201 |
| Wolff Henry Ward | Exec VP & CFO | 03/04/2015 | 142,700 |
| Wolff Henry Ward | Exec VP & CFO | 03/04/2015 | 180,000 |
| Mento Steven J | Director | 03/05/2015 | 45,400 |
| Mento Steven J | Director | 03/05/2015 | 118,939 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 03/05/2015 | 51,750 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 03/05/2015 | 274,282 |
| RINGO WILLIAM R | Director | 03/03/2015 | 14,102 |
| RINGO WILLIAM R | Director | 03/03/2015 | 37,862 |
| Gregory Philip D | SVP of Research & CSO | 03/02/2015 | 110,120 |
| Gregory Philip D | SVP of Research & CSO | 03/02/2015 | 258,938 |
| LANPHIER EDWARD O II | President & CEO | 02/17/2015 | 170,500 |
| LANPHIER EDWARD O II | President & CEO | 02/17/2015 | 392,150 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/17/2014 | 456,211 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 08/01/2014 | 356,100 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/01/2014 | 1,323,999 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/30/2014 | 1,361,606 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 06/16/2014 | 4,146,531 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/29/2014 | 17,464 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 06/09/2014 | 1,294,159 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/28/2014 | 727,474 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 06/06/2014 | 1,930,949 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/25/2014 | 583,951 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 06/05/2014 | 1,626,669 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/24/2014 | 1,523,235 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/07/2014 | 431,870 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/27/2014 | 3,570,473 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 06/05/2014 | 12,669,888 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/23/2014 | 684,713 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 06/04/2014 | 925,227 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/22/2014 | 764,537 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 06/03/2014 | 988,072 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/13/2014 | 735,305 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/30/2014 | 883,147 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/12/2014 | 386,330 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/29/2014 | 2,106,559 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/08/2014 | 1,032,587 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/28/2014 | 1,996,952 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/08/2014 | 1,888,274 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 05/07/2014 | 557,989 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/07/2014 | 519,310 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/15/2014 | 287,206 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/30/2014 | 1,674,679 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/04/2014 | 2,753,712 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/11/2014 | 1,694,299 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/28/2014 | 995,014 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/03/2014 | 3,241,999 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/25/2014 | 2,262,779 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/10/2014 | 1,237,339 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/17/2014 | 581,959 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/16/2014 | 307,658 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/14/2014 | 45,165 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/10/2014 | 53,326 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/22/2014 | 5,243,538 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/09/2014 | 1,136,424 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/13/2014 | 1,623,356 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/26/2014 | 3,808,711 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/25/2014 | 1,631,041 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/10/2014 | 279,180 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/21/2014 | 2,159,989 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/07/2014 | 5,748,552 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/28/2014 | 1,436,056 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/17/2014 | 1,200,835 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/27/2014 | 4,522,356 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/12/2014 | 2,889,432 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/19/2014 | 432,432 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 04/01/2014 | 4,502,381 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/06/2014 | 1,481,538 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/18/2014 | 1,994,573 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/05/2014 | 765,828 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/28/2014 | 760,145 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/12/2014 | 757,621 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/26/2014 | 1,452,243 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/11/2014 | 825,275 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/06/2014 | 1,890,245 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/06/2014 | 134,683 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/18/2014 | 202,278 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/03/2014 | 1,529,902 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/14/2014 | 286,166 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/13/2014 | 284,438 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/27/2014 | 623,499 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/20/2014 | 649,869 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 03/06/2014 | 6,831,412 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/07/2014 | 642,432 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 02/19/2014 | 124,420 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner. | 12/13/2013 | 60,921 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner. | 12/12/2013 | 116,071 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner. | 01/09/2014 | 1,329,365 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/17/2013 | 187,895 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/22/2013 | 1,065,610 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/19/2013 | 2,065,714 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/18/2013 | 741,498 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/17/2013 | 493,401 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/25/2013 | 3,582,848 |
| RA CAPITAL MANAGEMENT, LLC | Former 10% Owner | 07/23/2013 | 46,938 |
| Ramasastry Saira | Director | 02/12/2015 | 50,300 |
| Ramasastry Saira | Director | 02/12/2015 | 150,000 |
| Wolff Henry Ward | Exec VP & CFO | 02/10/2015 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 02/10/2015 | 151,750 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 02/05/2015 | 91,509 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 02/05/2015 | 193,950 |
| RINGO WILLIAM R | Director | 02/03/2015 | 14,102 |
| RINGO WILLIAM R | Director | 02/03/2015 | 27,940 |
| Gregory Philip D | SVP of Research & CSO | 02/02/2015 | 77,000 |
| Gregory Philip D | SVP of Research & CSO | 02/02/2015 | 192,829 |
| LANPHIER EDWARD O II | President & CEO | 01/16/2015 | 68,200 |
| LANPHIER EDWARD O II | President & CEO | 01/15/2015 | 102,300 |
| LANPHIER EDWARD O II | President & CEO | 01/16/2015 | 142,853 |
| LANPHIER EDWARD O II | President & CEO | 01/15/2015 | 212,769 |
| Wolff Henry Ward | Exec VP & CFO | 01/12/2015 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 01/12/2015 | 190,450 |
| RINGO WILLIAM R | Director | 01/05/2015 | 14,102 |
| RINGO WILLIAM R | Director | 01/05/2015 | 33,430 |
| LARSON JOHN WILLIAM | Director | 01/05/2015 | 102,850 |
| LARSON JOHN WILLIAM | Director | 01/05/2015 | 226,550 |
| Gregory Philip D | SVP, Research & CSO | 01/02/2015 | 110,120 |
| Gregory Philip D | SVP, Research & CSO | 01/02/2015 | 236,664 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 01/05/2015 | 102,300 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 01/05/2015 | 227,854 |
| Wolff Henry Ward | Exec VP & CFO | 12/15/2014 | 589,587 |
| NICHOL GEOFFREY | Executive Vice President, R&D | 12/15/2014 | 615,217 |
| LANPHIER EDWARD O II | President & CEO | 12/15/2014 | 1,422,723 |
| LANPHIER EDWARD O II | President & CEO | 12/15/2014 | 102,750 |
| LANPHIER EDWARD O II | President & CEO | 12/15/2014 | 384,912 |
| LARSON JOHN WILLIAM | Director | 12/15/2014 | 89,250 |
| LARSON JOHN WILLIAM | Director | 12/15/2014 | 162,829 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/15/2014 | 405,006 |
| Gregory Philip D | Vice President, Research & CSO | 12/15/2014 | 448,587 |
| Wolff Henry Ward | Exec VP & CFO | 12/15/2014 | 589,587 |
| Mento Steven J | Director | 12/11/2014 | 41,000 |
| Mento Steven J | Director | 12/11/2014 | 95,310 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/05/2014 | 102,300 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/05/2014 | 168,197 |
| LARSON JOHN WILLIAM | Director | 12/09/2014 | 45,400 |
| LARSON JOHN WILLIAM | Director | 12/09/2014 | 120,000 |
| Gregory Philip D | SVP of Research & CSO | 12/01/2014 | 77,000 |
| Gregory Philip D | SVP of Research & CSO | 12/01/2014 | 175,191 |
| LANPHIER EDWARD O II | President & CEO | 11/17/2014 | 102,750 |
| LANPHIER EDWARD O II | President & CEO | 11/17/2014 | 280,842 |
| Wolff Henry Ward | Exec VP & CFO | 11/10/2014 | 22,748 |
| LARSON JOHN WILLIAM | Director | 11/12/2014 | 41,000 |
| LARSON JOHN WILLIAM | Director | 11/12/2014 | 120,007 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 11/05/2014 | 83,877 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 11/05/2014 | 170,258 |
| Gregory Philip D | SVP of Research & CSO | 11/03/2014 | 79,240 |
| Gregory Philip D | SVP of Research & CSO | 11/03/2014 | 178,704 |
| LARSON JOHN WILLIAM | Director | 10/28/2014 | 72,800 |
| LARSON JOHN WILLIAM | Director | 10/28/2014 | 120,153 |
| LANPHIER EDWARD O II | President & CEO | 10/15/2014 | 102,750 |
| LANPHIER EDWARD O II | President & CEO | 10/15/2014 | 262,365 |
| Wolff Henry Ward | Exec VP & CFO | 10/10/2014 | 20,200 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 10/06/2014 | 61,650 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 10/06/2014 | 160,865 |
| Gregory Philip D | SVP of Research & CSO | 10/01/2014 | 84,840 |
| Gregory Philip D | SVP of Research & CSO | 10/01/2014 | 162,028 |
| LANPHIER EDWARD O II | President & CEO | 09/15/2014 | 102,750 |
| LANPHIER EDWARD O II | President & CEO | 09/15/2014 | 303,382 |
| Wolff Henry Ward | Exec VP & CFO | 09/10/2014 | 24,620 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 09/05/2014 | 61,650 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 09/05/2014 | 183,072 |
| LARSON JOHN WILLIAM | Director | 09/04/2014 | 77,300 |
| LARSON JOHN WILLIAM | Director | 09/04/2014 | 128,082 |
| Gregory Philip D | SVP of Research & CSO | 09/02/2014 | 84,840 |
| Gregory Philip D | SVP of Research & CSO | 09/02/2014 | 201,798 |
| LANPHIER EDWARD O II | President & CEO | 08/15/2014 | 102,750 |
| LANPHIER EDWARD O II | President & CEO | 08/15/2014 | 348,797 |
| Ramasastry Saira | Director | 08/08/2014 | 50,300 |
| Ramasastry Saira | Director | 08/08/2014 | 140,000 |
| Wolff Henry Ward | Exec VP & CFO | 08/11/2014 | 58,240 |
| Wolff Henry Ward | Exec VP & CFO | 08/11/2014 | 141,677 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 08/05/2014 | 54,260 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 08/05/2014 | 194,846 |
| LARSON JOHN WILLIAM | Director | 08/04/2014 | 40,000 |
| LARSON JOHN WILLIAM | Director | 08/04/2014 | 125,578 |
| Gregory Philip D | SVP of Research & CSO | 08/01/2014 | 84,840 |
| Gregory Philip D | SVP of Research & CSO | 08/01/2014 | 188,149 |
| LANPHIER EDWARD O II | President & CEO | 07/18/2014 | 102,750 |
| LANPHIER EDWARD O II | President & CEO | 07/18/2014 | 303,940 |
| Wolff Henry Ward | Exec VP & CFO | 07/10/2014 | 99,590 |
| Wolff Henry Ward | Exec VP & CFO | 07/10/2014 | 198,902 |
| Gregory Philip D | SVP of Research & CSO | 07/01/2014 | 84,840 |
| Gregory Philip D | SVP of Research & CSO | 07/01/2014 | 234,865 |
| Ramasastry Saira | Director | 06/23/2014 | 27,917 |
| Ramasastry Saira | Director | 06/23/2014 | 86,217 |
| LANPHIER EDWARD O II | President & CEO | 06/16/2014 | 410,138 |
| Mento Steven J | Director | 06/09/2014 | 42,472 |
| Mento Steven J | Director | 06/09/2014 | 64,920 |
| Wolff Henry Ward | Exec VP & CFO | 06/10/2014 | 100,490 |
| Wolff Henry Ward | Exec VP & CFO | 06/10/2014 | 234,328 |
| Gregory Philip D | SVP of Research & CSO | 06/02/2014 | 84,840 |
| Gregory Philip D | SVP of Research & CSO | 06/02/2014 | 192,723 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 05/27/2014 | 55,230 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 05/27/2014 | 203,531 |
| LANPHIER EDWARD O II | President & CEO | 05/15/2014 | 328,542 |
| Wolff Henry Ward | Exec VP & CFO | 05/12/2014 | 100,490 |
| Wolff Henry Ward | Exec VP & CFO | 05/12/2014 | 192,756 |
| Gregory Philip D | SVP of Research & CSO | 05/01/2014 | 84,840 |
| Gregory Philip D | SVP of Research & CSO | 05/01/2014 | 205,179 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 04/28/2014 | 55,230 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 04/28/2014 | 204,532 |
| LARSON JOHN WILLIAM | Director | 04/28/2014 | 56,600 |
| LARSON JOHN WILLIAM | Director | 04/28/2014 | 134,786 |
| LANPHIER EDWARD O II | President & CEO | 04/15/2014 | 355,012 |
| Wolff Henry Ward | Exec VP & CFO | 04/10/2014 | 100,490 |
| Wolff Henry Ward | Exec VP & CFO | 04/10/2014 | 235,798 |
| Gregory Philip D | Sr. VP Res. & CSO | 04/01/2014 | 113,480 |
| Gregory Philip D | Sr. VP Res. & CSO | 04/01/2014 | 267,000 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 03/26/2014 | 55,230 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 03/26/2014 | 279,695 |
| Gregory Philip D | See Remarks | 03/21/2014 | 114,662 |
| Gregory Philip D | See Remarks | 03/21/2014 | 335,763 |
| Ramasastry Saira | Director | 03/17/2014 | 50,300 |
| Ramasastry Saira | Director | 03/17/2014 | 232,608 |
| Mento Steven J | Director | 03/14/2014 | 37,624 |
| Mento Steven J | Director | 03/14/2014 | 138,955 |
| LANPHIER EDWARD O II | President & CEO | 03/17/2014 | 259,500 |
| LANPHIER EDWARD O II | President & CEO | 03/17/2014 | 1,160,930 |
| Wolff Henry Ward | Exec VP & CFO | 03/10/2014 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 03/10/2014 | 223,071 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 02/26/2014 | 55,230 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 02/26/2014 | 295,752 |
| LANPHIER EDWARD O II | President & CEO | 02/18/2014 | 259,500 |
| LANPHIER EDWARD O II | President & CEO | 02/18/2014 | 904,350 |
| RINGO WILLIAM R | Director | 02/14/2014 | 141,050 |
| RINGO WILLIAM R | Director | 02/14/2014 | 451,575 |
| Wolff Henry Ward | Exec VP & CFO | 02/10/2014 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 02/10/2014 | 192,638 |
| Gregory Philip D | Vice President, Research & CSO | 02/03/2014 | 56,370 |
| Gregory Philip D | Vice President, Research & CSO | 02/03/2014 | 282,516 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 01/27/2014 | 55,230 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 01/27/2014 | 278,729 |
| LANPHIER EDWARD O II | President & CEO | 01/15/2014 | 319,500 |
| LANPHIER EDWARD O II | President & CEO | 01/15/2014 | 925,675 |
| Cleveland Paul B | Director | 01/15/2014 | 41,915 |
| Cleveland Paul B | Director | 01/15/2014 | 155,694 |
| Wolff Henry Ward | Exec VP & CFO | 01/10/2014 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 01/10/2014 | 186,893 |
| Gregory Philip D | Vice President, Research & CSO | 01/02/2014 | 56,370 |
| Gregory Philip D | Vice President, Research & CSO | 01/02/2014 | 203,340 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/26/2013 | 55,230 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/26/2013 | 215,477 |
| LANPHIER EDWARD O II | President & CEO | 12/18/2013 | 319,500 |
| LANPHIER EDWARD O II | President & CEO | 12/18/2013 | 623,705 |
| Gregory Philip D | Vice President, Research & CSO | 12/12/2013 | 189,714 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/12/2013 | 179,170 |
| LANPHIER EDWARD O II | President & CEO | 12/12/2013 | 695,664 |
| NICHOL GEOFFREY | Executive Vice President, R&D | 12/12/2013 | 274,045 |
| Wolff Henry Ward | Exec VP & CFO | 12/12/2013 | 252,969 |
| Wolff Henry Ward | Exec VP & CFO | 12/10/2013 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 12/10/2013 | 119,670 |
| Gregory Philip D | Vice President, Research & CSO | 12/02/2013 | 56,370 |
| Gregory Philip D | Vice President, Research & CSO | 12/02/2013 | 174,835 |
| Cleveland Paul B | Director | 12/02/2013 | 64,100 |
| Cleveland Paul B | Director | 12/02/2013 | 116,393 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 11/26/2013 | 58,570 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 11/26/2013 | 177,378 |
| Wolff Henry Ward | Exec VP & CFO | 11/13/2013 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 11/13/2013 | 100,000 |
| LANPHIER EDWARD O II | President & CEO | 11/15/2013 | 252,723 |
| Gregory Philip D | Vice President, Research & CSO | 11/01/2013 | 27,600 |
| Gregory Philip D | Vice President, Research & CSO | 11/05/2013 | 28,770 |
| Gregory Philip D | Vice President, Research & CSO | 11/05/2013 | 70,000 |
| Gregory Philip D | Vice President, Research & CSO | 11/01/2013 | 74,065 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 10/28/2013 | 58,570 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 10/28/2013 | 155,779 |
| Cleveland Paul B | Director | 10/21/2013 | 45,400 |
| Cleveland Paul B | Director | 10/21/2013 | 109,336 |
| LANPHIER EDWARD O II | President & CEO | 10/15/2013 | 283,083 |
| Wolff Henry Ward | Exec VP & CFO | 10/10/2013 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 10/10/2013 | 112,763 |
| Gregory Philip D | Vice President, Research & CSO | 10/01/2013 | 63,930 |
| Gregory Philip D | Vice President, Research & CSO | 10/01/2013 | 158,081 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 09/26/2013 | 58,570 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 09/26/2013 | 158,574 |
| LANPHIER EDWARD O II | President & CEO | 09/16/2013 | 282,127 |
| Wolff Henry Ward | Exec VP & CFO | 09/10/2013 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 09/10/2013 | 108,593 |
| Gregory Philip D | Vice President, Research & CSO | 09/03/2013 | 63,930 |
| Gregory Philip D | Vice President, Research & CSO | 09/03/2013 | 154,981 |
| Cleveland Paul B | Director | 09/03/2013 | 14,847 |
| Cleveland Paul B | Director | 09/03/2013 | 74,978 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 08/26/2013 | 49,930 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 08/26/2013 | 150,606 |
| LANPHIER EDWARD O II | President & CEO | 08/15/2013 | 252,880 |
| Wolff Henry Ward | Exec VP & CFO | 08/13/2013 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 08/13/2013 | 100,000 |
| Gregory Philip D | Vice President, Research & CSO | 08/01/2013 | 63,930 |
| Gregory Philip D | Vice President, Research & CSO | 08/01/2013 | 148,321 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 07/26/2013 | 49,930 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 07/26/2013 | 151,308 |
| Gregory Philip D | Vice President, Research & CSO | 07/29/2013 | 63,120 |
| Gregory Philip D | Vice President, Research & CSO | 07/29/2013 | 150,556 |
| LANPHIER EDWARD O II | President & CEO | 07/17/2013 | 250,003 |
| Wolff Henry Ward | Exec VP & CFO | 07/17/2013 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 07/17/2013 | 100,000 |
| Cleveland Paul B | Director | 07/15/2013 | 16,320 |
| Cleveland Paul B | Director | 07/15/2013 | 76,718 |
| Gregory Philip D | Vice President, Research & CSO | 06/03/2013 | 10,350 |
| Gregory Philip D | Vice President, Research & CSO | 06/03/2013 | 23,640 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 05/28/2013 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 05/28/2013 | 124,818 |
| LARSON JOHN WILLIAM | Director | 05/07/2013 | 24,500 |
| Gregory Philip D | Vice President, Research & CSO | 05/01/2013 | 20,700 |
| Gregory Philip D | Vice President, Research & CSO | 05/01/2013 | 60,557 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 04/26/2013 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 04/26/2013 | 160,746 |
| LANPHIER EDWARD O II | President & CEO | 04/16/2013 | 1,900 |
| LANPHIER EDWARD O II | President & CEO | 04/15/2013 | 50,000 |
| Wolff Henry Ward | Exec VP & CFO | 04/10/2013 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 04/10/2013 | 100,000 |
| Gregory Philip D | Vice President, Research & CSO | 04/01/2013 | 20,700 |
| Gregory Philip D | Vice President, Research & CSO | 04/01/2013 | 57,240 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 03/26/2013 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 03/26/2013 | 137,724 |
| Gregory Philip D | Vice President, Research & CSO | 03/01/2013 | 29,520 |
| Gregory Philip D | Vice President, Research & CSO | 03/01/2013 | 60,005 |
| Wolff Henry Ward | Exec VP & CFO | 02/28/2013 | 34,500 |
| Wolff Henry Ward | Exec VP & CFO | 02/28/2013 | 100,000 |
| LANPHIER EDWARD O II | President & CEO | 02/28/2013 | 250,000 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 02/26/2013 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 02/26/2013 | 129,600 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 01/28/2013 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 01/28/2013 | 145,158 |
| Gregory Philip D | Vice President, Research & CSO | 02/01/2013 | 29,520 |
| Gregory Philip D | Vice President, Research & CSO | 02/01/2013 | 57,195 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 01/28/2012 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 01/28/2012 | 145,158 |
| Wolff Henry Ward | Exec VP & CFO | 01/23/2013 | 27,600 |
| Wolff Henry Ward | Exec VP & CFO | 01/23/2013 | 100,000 |
| LANPHIER EDWARD O II | President & CEO | 01/23/2013 | 83,008 |
| LANPHIER EDWARD O II | President & CEO | 01/24/2013 | 3,000 |
| Gregory Philip D | Vice President, Research & CSO | 01/02/2013 | 29,520 |
| Gregory Philip D | Vice President, Research & CSO | 01/02/2013 | 36,300 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/26/2012 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 12/26/2012 | 100,718 |
| Gregory Philip D | Vice President, Research & CSO | 12/10/2012 | 131,040 |
| LARSON JOHN WILLIAM | Director | 12/03/2012 | 84,634 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 11/27/2012 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 11/26/2012 | 25,232 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 11/27/2012 | 84,000 |
| LARSON JOHN WILLIAM | Director | 11/01/2012 | 82,764 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 10/26/2012 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 10/26/2012 | 113,935 |
| Gregory Philip D | VP, Therapeutic Dev. & CMO | 10/17/2012 | 29,520 |
| Gregory Philip D | VP, Therapeutic Dev. & CMO | 10/17/2012 | 36,000 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 10/15/2012 | 28,283 |
| LARSON JOHN WILLIAM | Director | 10/01/2012 | 93,035 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 09/05/2012 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 09/05/2012 | 84,000 |
| LARSON JOHN WILLIAM | Director | 09/04/2012 | 79,494 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 08/27/2012 | 25,903 |
| LARSON JOHN WILLIAM | Director | 08/01/2012 | 78,825 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 07/27/2012 | 54,150 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 07/27/2012 | 84,000 |
| ANDO DALE G | VP, Therapeutic Dev. & CMO | 07/26/2012 | 25,320 |
| LARSON JOHN WILLIAM | Director | 07/02/2012 | 78,556 |
| LARSON JOHN WILLIAM | Director | 06/15/2012 | 75,000 |
| Wolff Henry Ward | Exec VP & CFO | 12/30/2011 | 6,345 |
| Wolff Henry Ward | Exec VP & CFO | 09/30/2011 | 9,718 |
| Gregory Philip D | CSO & Vice President, Research | 09/09/2011 | 8,625 |
| Gregory Philip D | CSO & Vice President, Research | 09/09/2011 | 7,500 |
| Gregory Philip D | CSO & Vice President, Research | 09/09/2011 | 15,000 |
| Ichikawa David G | Senior VP, Bus. Dev. | 07/07/2011 | 20,760 |
| Ichikawa David G | Senior VP, Bus. Dev. | 07/07/2011 | 25,880 |
| Wolff Henry Ward | Exec VP & CFO | 06/30/2011 | 13,158 |
| Gregory Philip D | CSO & Vice President, Research | 07/01/2011 | 51,750 |
| Gregory Philip D | CSO & Vice President, Research | 07/01/2011 | 90,000 |
| Ichikawa David G | Senior VP, Bus. Dev. | 06/06/2011 | 20,760 |
| Ichikawa David G | Senior VP, Bus. Dev. | 06/06/2011 | 26,080 |
| Gregory Philip D | CSO & Vice President, Research | 06/01/2011 | 51,750 |
| Gregory Philip D | CSO & Vice President, Research | 06/01/2011 | 102,012 |
| Ichikawa David G | Senior VP, Bus. Dev. | 05/05/2011 | 20,760 |
| Ichikawa David G | Senior VP, Bus. Dev. | 05/05/2011 | 26,960 |
| Gregory Philip D | CSO & Vice President, Research | 05/02/2011 | 51,750 |
| Gregory Philip D | CSO & Vice President, Research | 05/02/2011 | 109,930 |
| Gregory Philip D | CSO & Vice President, Research | 04/25/2011 | 49,856 |
| Gregory Philip D | CSO & Vice President, Research | 04/25/2011 | 146,508 |
| Ichikawa David G | Senior VP, Bus. Dev. | 04/21/2011 | 41,520 |
| Ichikawa David G | Senior VP, Bus. Dev. | 04/21/2011 | 61,625 |
| Wolff Henry Ward | Exec VP & CFO | 03/31/2011 | 18,618 |
| Cleveland Paul B | Director | 02/28/2011 | 2,832 |
| Cleveland Paul B | Director | 02/28/2011 | 12,492 |
| Gregory Philip D | CSO & Vice President, Research | 03/01/2011 | 20,715 |
| Gregory Philip D | CSO & Vice President, Research | 02/28/2011 | 22,500 |
| Gregory Philip D | CSO & Vice President, Research | 02/01/2011 | 19,925 |
| Gregory Philip D | CSO & Vice President, Research | 01/03/2011 | 17,000 |
| Wolff Henry Ward | Exec VP & CFO | 12/31/2010 | 14,834 |
| Cleveland Paul B | Director | 12/22/2010 | 85,955 |
| Cleveland Paul B | Director | 12/22/2010 | 224,259 |
| Cleveland Paul B | Director | 12/20/2010 | 23,046 |
| Cleveland Paul B | Director | 12/20/2010 | 79,079 |
| Gregory Philip D | CSO & Vice President, Research | 12/08/2010 | 15,000 |
| Wolff Henry Ward | Exec VP & CFO | 09/30/2010 | 7,680 |
| LANPHIER EDWARD O II | President & CEO | 08/30/2010 | 30,050 |
| Wolff Henry Ward | Exec VP & CFO | 08/30/2010 | 27,000 |
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FUNDS WITH A POSITION IN SANGAMO THERAPEUTICS INC
| Fund | # Shares Owned | % of Portfolio | % Change | Investing Style |
|---|---|---|---|---|
| BLACKROCK INC. | 14,095,865 | 0.0002% | -10.77% | Other |
| D. E. SHAW & CO., INC. | 4,683,973 | 0.00222% | 86.72% | Other |
| GEODE CAPITAL MANAGEMENT, LLC | 3,206,310 | 0.00018% | 6.95% | Other |
| RENAISSANCE TECHNOLOGIES LLC | 3,145,878 | 0.00265% | 32.98% | Other |
| TUDOR INVESTMENT CORP ET AL | 363,490 | 0.00159% | No change | Event Driven, Other |
CHANGE IN SHARES OUTSTANDING FOR SANGAMO THERAPEUTICS INC
STOCK BUYBACKS FOR SANGAMO THERAPEUTICS INC
Period of Report
Previous Period
% Change in Shares
10-K/10-Q Filings
Quarter
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Period of Report: 12/31/2023
10-K/10-Q Filings: View
Previous Period
% Change in Shares
Quarter
09/30/2023
0.27%
1Q
06/30/2023
1.91%
2Q
03/31/2023
5.01%
3Q
12/31/2022
7.78%
4Q
09/30/2022
12.41%
5Q
06/30/2022
19.91%
6Q
03/31/2022
21.50%
7Q
12/31/2021
21.88%
8Q
09/30/2021
22.18%
9Q
06/30/2021
23.38%
10Q
03/31/2021
24.13%
11Q
12/31/2020
25.50%
12Q
09/30/2020
25.90%
13Q
06/30/2020
27.83%
14Q
03/31/2020
53.07%
15Q
12/31/2019
53.22%
16Q
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BUYBACK ANNOUNCEMENT(S) FOR SANGAMO THERAPEUTICS INC
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