Pacira BioSciences Inc. (PCRX) NASDAQ
$57.85 -0.45 (-0.77%)
Market Cap: $2.63B
As of 07/01/22 04:00 PM EDT. Market closed.
Pacira BioSciences Inc. (PCRX) NASDAQ
$57.85 -0.45 (-0.77%)
Market Cap: $2.63B
As of 07/01/22 04:00 PM EDT. Market closed.
Pacira BioSciences, Inc.is the industry leader in its commitment to non-opioid pain management and regenerative health solutions to improve patients' journeys along the neural pain pathway. The company's long-acting local analgesic, EXPAREL ® (bupivacaine liposome injectable suspension) was commercially launched in the United States in April 2012. EXPAREL utilizes DepoFoam®, a unique and ... read more
Pacira BioSciences, Inc.is the industry leader in its commitment to non-opioid pain management and regenerative health solutions to improve patients' journeys along the neural pain pathway. The company's long-acting local analgesic, EXPAREL ® (bupivacaine liposome injectable suspension) was commercially launched in the United States in April 2012. EXPAREL utilizes DepoFoam®, a unique and proprietary product delivery technology that encapsulates drugs without altering their molecular structure, and releases them over a desired period of time. In April 2019, Pacira acquired the iovera° system, a handheld cryoanalgesia device used to deliver precise, controlled doses of cold temperature only to targeted nerves. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO Compensation (Base)
$807,695
URL
Address
5 Sylvan Way Ste 300, New Jersey, Parsippany, 07054-3813.
PRICE CHART
From:
To:
NEWS
KEY STATS
Open
$57.70
Previous Close
$58.30
Days Range
$56.69 - $58.40
52 week range
$45.05 - $82.16
Volume
436,089
Avg. Volume (30 days)
523,157
Market Cap
$2.63B
Dividend Yield
0.00%
P/E
68.38
Shares Outstanding
45,436,752
Open
$57.70
Previous Close
$58.30
Days Range
$56.69 - $58.40
52 week range
$45.05 - $82.16
Volume
436,089
Avg. Volume (30 days)
523,157
Market Cap
$2.63B
Dividend Yield
0.00%
P/E
68.38
Shares Outstanding
45,436,752
Open in:
Open in:
INSIDER TRANSACTIONS FOR PACIRA BIOSCIENCES INC
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| LARANJEIRA CHARLES ANTHONY | Chief Technical Officer | Jun 14, 2022 | Option Exercise | $38.35 | 6,000 | 230,100 | 41,752 | Jun 16, 2022, 04:05 PM |
| STACK DAVID M | CEO and Chairman | Jun 08, 2022 | Sale | $59.85 | 13,828 | 827,658 | 149,040 | Jun 08, 2022, 07:51 PM |
| STACK DAVID M | CEO and Chairman | Jun 06, 2022 | Sale | $61.37 | 11,965 | 734,340 | 156,079 | Jun 08, 2022, 07:51 PM |
| WINSTON ROY | Chief Medical Officer | Jun 06, 2022 | Option Exercise | $34.38 | 6,250 | 214,844 | 50,607 | Jun 08, 2022, 07:48 PM |
| WINSTON ROY | Chief Medical Officer | Jun 06, 2022 | Sale | $61.39 | 17,546 | 1,077,135 | 48,072 | Jun 08, 2022, 07:48 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jun 06, 2022 | Sale | $61.37 | 3,969 | 243,593 | 18,299 | Jun 08, 2022, 07:46 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jun 07, 2022 | Sale | $59.51 | 4,649 | 276,662 | 13,650 | Jun 08, 2022, 07:46 PM |
| SLONIN JONATHAN | Chief Clinical Officer | Jun 06, 2022 | Sale | $61.37 | 362 | 22,217 | 28,197 | Jun 08, 2022, 07:45 PM |
| Riker Lauren Bullaro | Senior Vice President, Finance | Jun 06, 2022 | Sale | $61.37 | 1,150 | 70,580 | 14,002 | Jun 08, 2022, 07:44 PM |
| Reinhart Charles A. III | Chief Financial Officer | Jun 06, 2022 | Sale | $61.37 | 2,516 | 154,417 | 28,283 | Jun 08, 2022, 07:41 PM |
| REINHARDT MAX | President, Rest of World | Jun 07, 2022 | Sale | $62.00 | 2,433 | 150,846 | 24,400 | Jun 08, 2022, 07:40 PM |
| REINHARDT MAX | President, Rest of World | Jun 06, 2022 | Sale | $61.37 | 2,817 | 172,891 | 26,833 | Jun 08, 2022, 07:40 PM |
| LARANJEIRA CHARLES ANTHONY | Chief Technical Officer | Jun 08, 2022 | Sale | $59.82 | 4,937 | 295,316 | 28,268 | Jun 08, 2022, 07:39 PM |
| LARANJEIRA CHARLES ANTHONY | Chief Technical Officer | Jun 06, 2022 | Sale | $61.37 | 2,813 | 172,645 | 30,789 | Jun 08, 2022, 07:39 PM |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | Jun 07, 2022 | Sale | $60.11 | 2,570 | 154,473 | 13,830 | Jun 08, 2022, 07:34 PM |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | Jun 06, 2022 | Sale | $61.37 | 2,980 | 182,895 | 14,570 | Jun 08, 2022, 07:34 PM |
| McLoughlin Dennis | Chief Customer Officer | Jun 06, 2022 | Sale | $61.37 | 2,140 | 131,340 | 31,820 | Jun 08, 2022, 07:31 PM |
| GAUGLER DARYL | Chief Operating Officer | Jun 06, 2022 | Sale | $61.37 | 1,106 | 67,880 | 11,494 | Jun 08, 2022, 07:24 PM |
| SLONIN JONATHAN | Chief Clinical Officer | May 23, 2022 | Option Exercise | $52.37 | 2,000 | 104,740 | 28,559 | May 25, 2022, 04:16 PM |
| Froimson Mark | Director | May 09, 2022 | Sale | $59.37 | 1,000 | 59,370 | 4,908 | May 11, 2022, 04:13 PM |
| STACK DAVID M | CEO and Chairman | Apr 28, 2022 | Option Exercise | $10.81 | 22,500 | 243,225 | 168,044 | May 02, 2022, 06:34 PM |
| REINHARDT MAX | President, Rest of World | Apr 21, 2022 | Option Exercise | $42.54 | 12,500 | 531,750 | 39,474 | Apr 25, 2022, 04:12 PM |
| REINHARDT MAX | President, Rest of World | Apr 21, 2022 | Sale | $73.25 | 9,824 | 719,647 | 29,650 | Apr 25, 2022, 04:12 PM |
| REINHARDT MAX | President, Rest of World | Apr 18, 2022 | Option Exercise | $42.54 | 12,500 | 531,750 | 30,000 | Apr 20, 2022, 08:25 PM |
| REINHARDT MAX | President, Rest of World | Apr 20, 2022 | Option Exercise | $42.54 | 12,500 | 531,750 | 36,738 | Apr 20, 2022, 08:25 PM |
| REINHARDT MAX | President, Rest of World | Apr 19, 2022 | Option Exercise | $42.54 | 12,500 | 531,750 | 33,559 | Apr 20, 2022, 08:25 PM |
| REINHARDT MAX | President, Rest of World | Apr 20, 2022 | Sale | $73.99 | 9,764 | 722,438 | 26,974 | Apr 20, 2022, 08:25 PM |
| REINHARDT MAX | President, Rest of World | Apr 19, 2022 | Sale | $72.25 | 9,321 | 673,442 | 24,238 | Apr 20, 2022, 08:25 PM |
| REINHARDT MAX | President, Rest of World | Apr 18, 2022 | Sale | $73.55 | 8,941 | 657,611 | 21,059 | Apr 20, 2022, 08:25 PM |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | Apr 06, 2022 | Option Exercise | $40.77 | 22,500 | 917,407 | 40,050 | Apr 08, 2022, 04:16 PM |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | Apr 06, 2022 | Sale | $76.42 | 22,500 | 1,719,393 | 23,990 | Apr 08, 2022, 04:16 PM |
| STACK DAVID M | CEO and Chairman | Mar 31, 2022 | Option Exercise | $10.81 | 22,500 | 243,225 | 145,544 | Apr 05, 2022, 05:26 PM |
| Williams Kristen Marie | Chief Administrative Officer | Mar 21, 2022 | Option Exercise | $42.67 | 7,253 | 309,462 | 29,521 | Mar 23, 2022, 04:37 PM |
| Williams Kristen Marie | Chief Administrative Officer | Mar 21, 2022 | Sale | $72.67 | 7,253 | 527,075 | 22,268 | Mar 23, 2022, 04:37 PM |
| Riker Lauren Bullaro | Senior Vice President, Finance | Mar 10, 2022 | Option Exercise | $10.81 | 9,300 | 100,533 | 24,452 | Mar 14, 2022, 05:00 PM |
| Riker Lauren Bullaro | Senior Vice President, Finance | Mar 10, 2022 | Sale | $71.22 | 9,300 | 662,331 | 16,052 | Mar 14, 2022, 05:00 PM |
| PACE GARY W | Director | Mar 03, 2022 | Option Exercise | $10.81 | 7,000 | 75,670 | 136,530 | Mar 07, 2022, 08:07 PM |
| LONGENECKER JOHN P PHD | Director | Mar 03, 2022 | Option Exercise | $10.81 | 7,000 | 75,670 | 25,823 | Mar 07, 2022, 08:03 PM |
| LONGENECKER JOHN P PHD | Director | Mar 03, 2022 | Sale | $71.74 | 7,000 | 502,145 | 18,823 | Mar 07, 2022, 08:03 PM |
| PACE GARY W | Director | Mar 01, 2022 | Option Exercise | $11.02 | 1,359 | 14,976 | 130,889 | Mar 01, 2022, 06:03 PM |
| PACE GARY W | Director | Feb 28, 2022 | Option Exercise | $11.02 | 28,641 | 315,624 | 158,171 | Mar 01, 2022, 06:03 PM |
| PACE GARY W | Director | Mar 01, 2022 | Sale | $67.75 | 1,359 | 92,072 | 129,530 | Mar 01, 2022, 06:03 PM |
| PACE GARY W | Director | Feb 28, 2022 | Sale | $66.83 | 28,641 | 1,914,078 | 129,530 | Mar 01, 2022, 06:03 PM |
| Williams Kristen Marie | Chief Administrative Officer | Feb 25, 2022 | Option Exercise | $38.35 | 2,050 | 78,617 | 24,318 | Mar 01, 2022, 05:43 PM |
| Williams Kristen Marie | Chief Administrative Officer | Feb 16, 2022 | Option Exercise | $38.35 | 10 | 383 | 22,278 | Mar 01, 2022, 05:43 PM |
| Williams Kristen Marie | Chief Administrative Officer | Feb 16, 2022 | Sale | $65.00 | 10 | 650 | 22,268 | Mar 01, 2022, 05:43 PM |
| Williams Kristen Marie | Chief Administrative Officer | Feb 25, 2022 | Sale | $67.02 | 2,050 | 137,390 | 24,268 | Mar 01, 2022, 05:43 PM |
| Williams Kristen Marie | Chief Administrative Officer | Feb 04, 2022 | Option Exercise | $38.35 | 1,000 | 38,350 | 23,268 | Feb 08, 2022, 04:25 PM |
| Williams Kristen Marie | Chief Administrative Officer | Feb 04, 2022 | Sale | $65.18 | 1,000 | 65,180 | 22,268 | Feb 08, 2022, 04:25 PM |
| STACK DAVID M | CEO and Chairman | Jan 25, 2022 | Option Exercise | $10.81 | 13,670 | 147,773 | 123,044 | Jan 27, 2022, 04:27 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jan 21, 2022 | Option Exercise | $38.35 | 200 | 7,670 | 22,468 | Jan 25, 2022, 04:36 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jan 21, 2022 | Sale | $65.41 | 200 | 13,082 | 22,268 | Jan 25, 2022, 04:36 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jan 18, 2022 | Option Exercise | $45.30 | 23,440 | 1,061,943 | 45,708 | Jan 20, 2022, 07:24 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jan 19, 2022 | Option Exercise | $38.35 | 2,199 | 84,332 | 24,467 | Jan 20, 2022, 07:24 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jan 18, 2022 | Sale | $65.26 | 23,440 | 1,529,586 | 22,668 | Jan 20, 2022, 07:24 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jan 19, 2022 | Sale | $65.51 | 2,199 | 144,056 | 22,268 | Jan 20, 2022, 07:24 PM |
| Riker Lauren Bullaro | Senior Vice President, Finance | Jan 18, 2022 | Option Exercise | $10.81 | 2,500 | 27,025 | 17,652 | Jan 20, 2022, 07:22 PM |
| Riker Lauren Bullaro | Senior Vice President, Finance | Jan 18, 2022 | Sale | $64.97 | 2,500 | 162,430 | 15,152 | Jan 20, 2022, 07:22 PM |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | Jan 18, 2022 | Sale | $63.55 | 224 | 14,235 | 17,550 | Jan 20, 2022, 07:21 PM |
| STACK DAVID M | CEO and Chairman | Jan 11, 2022 | Option Exercise | $10.81 | 15,000 | 162,150 | 109,374 | Jan 13, 2022, 04:11 PM |
| LARANJEIRA CHARLES ANTHONY | Chief Technical Officer | Nov 22, 2021 | Option Exercise | $44.10 | 7,500 | 330,750 | 33,602 | Nov 24, 2021, 04:25 PM |
| STACK DAVID M | CEO and Chairman | Nov 16, 2021 | Option Exercise | $10.81 | 15,000 | 162,150 | 94,085 | Nov 18, 2021, 04:22 PM |
| WINSTON ROY | Chief Medical Officer | Nov 04, 2021 | Option Exercise | $48.15 | 10,000 | 481,500 | 46,456 | Nov 08, 2021, 04:22 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jul 28, 2021 | Option Exercise | $10.81 | 2,410 | 26,052 | 15,562 | Jul 30, 2021, 04:21 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jul 29, 2021 | Option Exercise | $10.81 | 90 | 973 | 13,242 | Jul 30, 2021, 04:21 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jul 28, 2021 | Sale | $60.85 | 2,410 | 146,648 | 13,152 | Jul 30, 2021, 04:21 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jul 29, 2021 | Sale | $60.81 | 90 | 5,473 | 13,152 | Jul 30, 2021, 04:21 PM |
| REINHARDT MAX | President, Rest of World | Jul 02, 2021 | Sale | $59.76 | 421 | 25,159 | 17,500 | Jul 06, 2021, 06:14 PM |
| REINHARDT MAX | President, Rest of World | Jun 04, 2021 | Sale | $61.04 | 1,222 | 74,587 | 12,778 | Jun 08, 2021, 04:16 PM |
| REINHARDT MAX | President, Rest of World | Jun 07, 2021 | Sale | $60.50 | 2,278 | 137,819 | 10,500 | Jun 08, 2021, 04:16 PM |
| McLoughlin Dennis | Chief Customer Officer | Jun 04, 2021 | Sale | $61.04 | 1,895 | 115,665 | 27,541 | Jun 08, 2021, 04:15 PM |
| HASTINGS PAUL J | Director | Jun 04, 2021 | Sale | $62.19 | 630 | 39,180 | 5,486 | Jun 08, 2021, 04:13 PM |
| STACK DAVID M | CEO and Chairman | May 12, 2021 | Option Exercise | $10.81 | 21,250 | 229,713 | 97,311 | May 13, 2021, 06:01 PM |
| STACK DAVID M | CEO and Chairman | May 11, 2021 | Option Exercise | $10.81 | 21,250 | 229,713 | 97,311 | May 13, 2021, 06:01 PM |
| STACK DAVID M | CEO and Chairman | May 12, 2021 | Sale | $61.95 | 21,250 | 1,316,471 | 94,341 | May 13, 2021, 06:01 PM |
| STACK DAVID M | CEO and Chairman | May 11, 2021 | Sale | $60.93 | 21,250 | 1,294,827 | 83,993 | May 13, 2021, 06:01 PM |
| Williams Kristen Marie | Chief Administrative Officer | Apr 13, 2021 | Option Exercise | $40.28 | 21,823 | 878,943 | 46,710 | Apr 15, 2021, 08:35 PM |
| Williams Kristen Marie | Chief Administrative Officer | Apr 13, 2021 | Sale | $66.95 | 21,823 | 1,461,069 | 31,917 | Apr 15, 2021, 08:35 PM |
| WINSTON ROY | Chief Clinical Officer | Mar 31, 2021 | Option Exercise | $34.38 | 13,750 | 472,656 | 48,535 | Apr 02, 2021, 06:33 PM |
| WINSTON ROY | Chief Clinical Officer | Mar 31, 2021 | Sale | $70.61 | 22,224 | 1,569,195 | 32,172 | Apr 02, 2021, 06:33 PM |
| Riker Lauren Bullaro | Vice President, Finance | Mar 17, 2021 | Option Exercise | $10.81 | 2,000 | 21,620 | 15,181 | Mar 17, 2021, 08:03 PM |
| Riker Lauren Bullaro | Vice President, Finance | Mar 15, 2021 | Option Exercise | $10.81 | 1,520 | 16,431 | 14,701 | Mar 17, 2021, 08:03 PM |
| Riker Lauren Bullaro | Vice President, Finance | Mar 15, 2021 | Sale | $73.28 | 1,520 | 111,386 | 13,181 | Mar 17, 2021, 08:03 PM |
| Riker Lauren Bullaro | Vice President, Finance | Mar 17, 2021 | Sale | $70.01 | 2,000 | 140,020 | 13,181 | Mar 17, 2021, 08:03 PM |
| Froimson Mark | Director | Mar 15, 2021 | Sale | $72.26 | 734 | 53,039 | 5,242 | Mar 17, 2021, 08:01 PM |
| Wicki Andreas | Director | Mar 12, 2021 | Sale | $73.10 | 58,754 | 4,294,917 | 461,925 | Mar 16, 2021, 09:12 PM |
| Wicki Andreas | Director | Mar 15, 2021 | Sale | $73.68 | 10,601 | 781,082 | 451,324 | Mar 16, 2021, 09:12 PM |
| Wicki Andreas | Director | Mar 11, 2021 | Sale | $72.70 | 60,574 | 4,403,730 | 520,679 | Mar 11, 2021, 09:37 PM |
| Wicki Andreas | Director | Mar 10, 2021 | Sale | $71.78 | 76,480 | 5,489,734 | 581,253 | Mar 11, 2021, 09:37 PM |
| Wicki Andreas | Director | Mar 09, 2021 | Sale | $70.90 | 35,137 | 2,491,213 | 657,733 | Mar 11, 2021, 09:37 PM |
| HASTINGS PAUL J | Director | Mar 05, 2021 | Option Exercise | $13.98 | 3,000 | 41,940 | 9,116 | Mar 09, 2021, 04:12 PM |
| HASTINGS PAUL J | Director | Mar 05, 2021 | Sale | $65.88 | 3,000 | 197,640 | 6,116 | Mar 09, 2021, 04:12 PM |
| LONGENECKER JOHN P PHD | Director | Mar 01, 2021 | Option Exercise | $13.98 | 5,000 | 69,900 | 22,757 | Mar 03, 2021, 04:25 PM |
| LONGENECKER JOHN P PHD | Director | Mar 01, 2021 | Sale | $72.26 | 5,000 | 361,300 | 17,757 | Mar 03, 2021, 04:25 PM |
| STACK DAVID M | CEO and Chairman | Feb 02, 2021 | Option Exercise | $10.81 | 21,250 | 229,713 | 97,311 | Feb 04, 2021, 07:58 PM |
| STACK DAVID M | CEO and Chairman | Feb 03, 2021 | Option Exercise | $10.81 | 21,250 | 229,713 | 97,311 | Feb 04, 2021, 07:58 PM |
| STACK DAVID M | CEO and Chairman | Feb 03, 2021 | Sale | $71.21 | 21,250 | 1,513,259 | 90,411 | Feb 04, 2021, 07:58 PM |
| STACK DAVID M | CEO and Chairman | Feb 02, 2021 | Sale | $69.41 | 21,250 | 1,474,874 | 94,411 | Feb 04, 2021, 07:58 PM |
| REINHARDT MAX | President | Jan 06, 2021 | Sale | $60.81 | 110 | 6,689 | 14,000 | Jan 08, 2021, 04:39 PM |
| Brege Laura | Director | Nov 16, 2020 | Option Exercise | $13.98 | 12,000 | 167,760 | 19,921 | Nov 17, 2020, 05:39 PM |
| Brege Laura | Director | Nov 16, 2020 | Sale | $65.95 | 12,000 | 791,400 | 7,921 | Nov 17, 2020, 05:39 PM |
| Riker Lauren Bullaro | Vice President, Finance | Nov 13, 2020 | Option Exercise | $10.81 | 3,000 | 32,430 | 16,181 | Nov 17, 2020, 05:37 PM |
| Riker Lauren Bullaro | Vice President, Finance | Nov 13, 2020 | Sale | $63.81 | 3,000 | 191,430 | 13,181 | Nov 17, 2020, 05:37 PM |
| WINSTON ROY | Chief Clinical Officer | Nov 13, 2020 | Sale | $62.00 | 5,000 | 310,000 | 34,785 | Nov 17, 2020, 05:30 PM |
| REINHARDT MAX | President | Nov 13, 2020 | Option Exercise | $42.54 | 25,000 | 1,063,500 | 39,000 | Nov 17, 2020, 05:28 PM |
| REINHARDT MAX | President | Nov 13, 2020 | Sale | $63.38 | 25,000 | 1,584,390 | 35,000 | Nov 17, 2020, 05:28 PM |
| STACK DAVID M | CEO and Chairman | Oct 15, 2020 | Option Exercise | $10.81 | 30,000 | 324,300 | 203,377 | Oct 16, 2020, 04:26 PM |
| STACK DAVID M | CEO and Chairman | Oct 14, 2020 | Option Exercise | $10.81 | 30,000 | 324,300 | 203,377 | Oct 16, 2020, 04:26 PM |
| STACK DAVID M | CEO and Chairman | Oct 16, 2020 | Option Exercise | $10.81 | 30,000 | 324,300 | 203,377 | Oct 16, 2020, 04:26 PM |
| STACK DAVID M | CEO and Chairman | Oct 15, 2020 | Sale | $55.00 | 30,000 | 1,650,000 | 173,377 | Oct 16, 2020, 04:26 PM |
| STACK DAVID M | CEO and Chairman | Oct 14, 2020 | Sale | $55.53 | 30,000 | 1,665,900 | 173,377 | Oct 16, 2020, 04:26 PM |
| STACK DAVID M | CEO and Chairman | Oct 16, 2020 | Sale | $55.56 | 30,000 | 1,666,800 | 173,377 | Oct 16, 2020, 04:26 PM |
| PACE GARY W | Director | Sep 25, 2020 | Option Exercise | $16.67 | 70,000 | 1,166,900 | 129,949 | Sep 29, 2020, 05:16 PM |
| REINHARDT MAX | President | Sep 17, 2020 | Option Exercise | $42.54 | 25,000 | 1,063,500 | 39,000 | Sep 21, 2020, 06:23 PM |
| REINHARDT MAX | President | Sep 17, 2020 | Sale | $59.81 | 25,420 | 1,520,318 | 16,888 | Sep 21, 2020, 06:23 PM |
| Williams Kristen Marie | Chief Administrative Officer | Sep 16, 2020 | Option Exercise | $39.19 | 27,853 | 1,091,560 | 52,740 | Sep 17, 2020, 07:13 PM |
| Williams Kristen Marie | Chief Administrative Officer | Sep 15, 2020 | Option Exercise | $39.19 | 27,853 | 1,091,560 | 52,740 | Sep 17, 2020, 07:13 PM |
| Williams Kristen Marie | Chief Administrative Officer | Sep 17, 2020 | Option Exercise | $39.19 | 27,871 | 1,092,268 | 52,758 | Sep 17, 2020, 07:13 PM |
| Williams Kristen Marie | Chief Administrative Officer | Sep 15, 2020 | Sale | $59.39 | 27,853 | 1,654,058 | 38,118 | Sep 17, 2020, 07:13 PM |
| Williams Kristen Marie | Chief Administrative Officer | Sep 17, 2020 | Sale | $59.82 | 27,871 | 1,667,290 | 28,087 | Sep 17, 2020, 07:13 PM |
| Williams Kristen Marie | Chief Administrative Officer | Sep 16, 2020 | Sale | $60.14 | 27,853 | 1,675,150 | 46,131 | Sep 17, 2020, 07:13 PM |
| Riker Lauren Bullaro | Vice President, Finance | Sep 16, 2020 | Option Exercise | $10.81 | 3,000 | 32,430 | 16,181 | Sep 17, 2020, 07:10 PM |
| Riker Lauren Bullaro | Vice President, Finance | Sep 16, 2020 | Sale | $60.34 | 3,000 | 181,020 | 13,181 | Sep 17, 2020, 07:10 PM |
| Wicki Andreas | Director | Sep 09, 2020 | Sale | $62.02 | 2,216 | 137,436 | 692,970 | Sep 11, 2020, 08:03 PM |
| STACK DAVID M | CEO and Chairman | Aug 17, 2020 | Sale | $61.91 | 15,000 | 928,619 | 176,594 | Aug 19, 2020, 05:44 PM |
| Wicki Andreas | Director | Aug 13, 2020 | Sale | $61.47 | 34,904 | 2,145,549 | 695,186 | Aug 13, 2020, 08:58 PM |
| Wicki Andreas | Director | Aug 12, 2020 | Sale | $60.82 | 113,500 | 6,903,070 | 730,090 | Aug 13, 2020, 08:58 PM |
| Wicki Andreas | Director | Aug 11, 2020 | Sale | $61.32 | 106,772 | 6,546,747 | 889,741 | Aug 13, 2020, 08:58 PM |
| Riker Lauren Bullaro | Vice President, Finance | Aug 11, 2020 | Option Exercise | $10.34 | 8,180 | 84,581 | 20,813 | Aug 13, 2020, 04:35 PM |
| Riker Lauren Bullaro | Vice President, Finance | Aug 11, 2020 | Sale | $60.50 | 8,180 | 494,890 | 13,181 | Aug 13, 2020, 04:35 PM |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | Aug 03, 2020 | Option Exercise | $44.10 | 2,500 | 110,250 | 22,750 | Aug 05, 2020, 05:16 PM |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | Aug 03, 2020 | Sale | $52.68 | 2,500 | 131,700 | 20,796 | Aug 05, 2020, 05:16 PM |
| STACK DAVID M | CEO and Chairman | Jul 15, 2020 | Sale | $56.88 | 12,000 | 682,560 | 188,377 | Jul 17, 2020, 05:44 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 29, 2020 | Option Exercise | $10.34 | 6,000 | 62,040 | 18,633 | Jul 01, 2020, 09:20 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 29, 2020 | Sale | $49.47 | 6,000 | 296,800 | 16,633 | Jul 01, 2020, 09:20 PM |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | Jun 29, 2020 | Option Exercise | $42.07 | 56,250 | 2,366,587 | 80,351 | Jul 01, 2020, 09:17 PM |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | Jun 29, 2020 | Sale | $50.27 | 60,101 | 3,021,314 | 28,887 | Jul 01, 2020, 09:17 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jun 05, 2020 | Sale | $48.61 | 5,904 | 286,993 | 10,887 | Jun 08, 2020, 09:10 PM |
| Williams Kristen Marie | Chief Administrative Officer | Jun 04, 2020 | Sale | $46.33 | 2,402 | 111,287 | 16,791 | Jun 08, 2020, 09:10 PM |
| STACK DAVID M | CEO and Chairman | Jun 04, 2020 | Sale | $46.33 | 14,314 | 663,182 | 184,020 | Jun 08, 2020, 09:09 PM |
| STACK DAVID M | CEO and Chairman | Jun 08, 2020 | Sale | $48.12 | 17,111 | 823,403 | 168,630 | Jun 08, 2020, 09:09 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 05, 2020 | Sale | $48.37 | 1,752 | 84,744 | 7,833 | Jun 08, 2020, 09:08 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 04, 2020 | Sale | $46.33 | 879 | 40,725 | 9,585 | Jun 08, 2020, 09:08 PM |
| Reinhart Charles A. III | Chief Financial Officer | Jun 04, 2020 | Sale | $46.33 | 1,489 | 68,987 | 14,847 | Jun 08, 2020, 09:07 PM |
| McLoughlin Dennis | Chief Commercial Officer | Jun 04, 2020 | Sale | $46.33 | 1,447 | 67,041 | 14,898 | Jun 08, 2020, 09:07 PM |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | Jun 04, 2020 | Sale | $46.33 | 863 | 39,984 | 10,101 | Jun 08, 2020, 09:06 PM |
| HASTINGS PAUL J | Director | Jun 04, 2020 | Sale | $47.46 | 2,025 | 96,106 | 4,856 | Jun 08, 2020, 09:05 PM |
| Brege Laura | Director | Jun 05, 2020 | Sale | $48.70 | 2,100 | 102,270 | 6,661 | Jun 08, 2020, 09:04 PM |
| Riker Lauren Bullaro | Vice President, Finance | May 19, 2020 | Option Exercise | $10.34 | 2,000 | 20,680 | 12,464 | May 21, 2020, 07:19 PM |
| Riker Lauren Bullaro | Vice President, Finance | May 21, 2020 | Option Exercise | $10.34 | 2,000 | 20,680 | 12,464 | May 21, 2020, 07:19 PM |
| Riker Lauren Bullaro | Vice President, Finance | May 19, 2020 | Sale | $42.81 | 2,000 | 85,620 | 10,464 | May 21, 2020, 07:19 PM |
| Riker Lauren Bullaro | Vice President, Finance | May 21, 2020 | Sale | $45.26 | 2,000 | 90,520 | 10,464 | May 21, 2020, 07:19 PM |
| PACE GARY W | Director | Mar 12, 2020 | Option Exercise | $4.46 | 21,736 | 96,845 | 58,689 | Mar 16, 2020, 05:54 PM |
| LONGENECKER JOHN P PHD | Director | Mar 12, 2020 | Option Exercise | $1.61 | 3,736 | 6,015 | 16,497 | Mar 16, 2020, 05:53 PM |
| WINSTON ROY | Chief Clinical Officer | Mar 11, 2020 | Buy | $36.50 | 2,500 | 91,250 | 25,237 | Mar 12, 2020, 07:18 PM |
| STACK DAVID M | CEO and Chairman | Feb 21, 2020 | Option Exercise | $3.38 | 35,856 | 121,189 | 198,334 | Feb 25, 2020, 04:55 PM |
| Riker Lauren Bullaro | Vice President, Finance | Feb 10, 2020 | Option Exercise | $10.81 | 3,000 | 32,430 | 13,464 | Feb 12, 2020, 04:41 PM |
| Riker Lauren Bullaro | Vice President, Finance | Feb 10, 2020 | Sale | $48.81 | 3,000 | 146,430 | 12,464 | Feb 12, 2020, 04:41 PM |
| Riker Lauren Bullaro | Vice President, Finance | Feb 06, 2020 | Option Exercise | $10.81 | 830 | 8,972 | 11,294 | Feb 10, 2020, 06:19 PM |
| Riker Lauren Bullaro | Vice President, Finance | Feb 07, 2020 | Option Exercise | $10.81 | 170 | 1,838 | 10,634 | Feb 10, 2020, 06:19 PM |
| Riker Lauren Bullaro | Vice President, Finance | Feb 07, 2020 | Sale | $46.81 | 170 | 7,958 | 10,464 | Feb 10, 2020, 06:19 PM |
| Riker Lauren Bullaro | Vice President, Finance | Feb 06, 2020 | Sale | $46.81 | 830 | 38,852 | 10,464 | Feb 10, 2020, 06:19 PM |
| STACK DAVID M | CEO and Chairman | Jan 15, 2020 | Option Exercise | $10.81 | 25,000 | 270,250 | 26,208 | Jan 17, 2020, 06:13 PM |
| STACK DAVID M | CEO and Chairman | Jan 15, 2020 | Sale | $42.68 | 25,000 | 1,066,968 | 3,183 | Jan 17, 2020, 06:13 PM |
| STACK DAVID M | CEO and Chairman | Dec 26, 2019 | Option Exercise | $3.55 | 20,000 | 71,000 | 162,299 | Dec 30, 2019, 04:05 PM |
| Riker Lauren Bullaro | Vice President, Finance | Dec 23, 2019 | Option Exercise | $10.81 | 1,000 | 10,810 | 11,464 | Dec 26, 2019, 04:08 PM |
| Riker Lauren Bullaro | Vice President, Finance | Dec 23, 2019 | Sale | $45.92 | 1,000 | 45,920 | 10,464 | Dec 26, 2019, 04:08 PM |
| McLoughlin Dennis | Chief Commercial Officer | Dec 16, 2019 | Sale | $45.79 | 3,671 | 168,108 | 16,116 | Dec 18, 2019, 06:54 PM |
| LONGENECKER JOHN P PHD | Director | Dec 02, 2019 | Option Exercise | $1.61 | 4,000 | 6,440 | 14,061 | Dec 04, 2019, 04:46 PM |
| LONGENECKER JOHN P PHD | Director | Dec 02, 2019 | Sale | $46.13 | 1,300 | 59,972 | 12,761 | Dec 04, 2019, 04:46 PM |
| Riker Lauren Bullaro | Vice President, Finance | Nov 20, 2019 | Option Exercise | $10.81 | 1,000 | 10,810 | 11,640 | Nov 22, 2019, 07:28 PM |
| Riker Lauren Bullaro | Vice President, Finance | Nov 20, 2019 | Sale | $44.14 | 1,176 | 51,909 | 10,464 | Nov 22, 2019, 07:28 PM |
| STACK DAVID M | CEO and Chairman | Nov 15, 2019 | Option Exercise | $10.81 | 25,000 | 270,250 | 26,208 | Nov 19, 2019, 04:16 PM |
| STACK DAVID M | CEO and Chairman | Nov 15, 2019 | Sale | $42.81 | 25,000 | 1,070,250 | 1,208 | Nov 19, 2019, 04:16 PM |
| STACK DAVID M | CEO and Chairman | Nov 15, 2019 | Sale | $42.81 | 45,000 | 1,926,450 | 142,299 | Nov 19, 2019, 04:16 PM |
| Riker Lauren Bullaro | Vice President, Finance | Nov 11, 2019 | Option Exercise | $10.36 | 5,000 | 51,785 | 15,640 | Nov 12, 2019, 05:12 PM |
| Riker Lauren Bullaro | Vice President, Finance | Nov 11, 2019 | Sale | $43.59 | 5,000 | 217,950 | 10,640 | Nov 12, 2019, 05:12 PM |
| Scranton Richard | Chief Scientific Officer | Nov 08, 2019 | Option Exercise | $14.37 | 19,448 | 279,393 | 35,509 | Nov 12, 2019, 05:10 PM |
| Scranton Richard | Chief Scientific Officer | Nov 08, 2019 | Sale | $45.00 | 19,448 | 875,160 | 16,061 | Nov 12, 2019, 05:10 PM |
| STACK DAVID M | CEO and Chairman | Oct 02, 2019 | Option Exercise | $3.89 | 17,000 | 66,170 | 187,299 | Oct 04, 2019, 04:31 PM |
| STACK DAVID M | CEO and Chairman | Sep 18, 2019 | Option Exercise | $3.41 | 14,000 | 47,760 | 170,299 | Sep 20, 2019, 05:13 PM |
| STACK DAVID M | CEO and Chairman | Aug 15, 2019 | Option Exercise | $10.81 | 12,849 | 138,898 | 169,148 | Aug 16, 2019, 04:19 PM |
| STACK DAVID M | CEO and Chairman | Aug 15, 2019 | Sale | $39.15 | 12,849 | 503,092 | 158,690 | Aug 16, 2019, 04:19 PM |
| Williams Kristen Marie | Chief Administrative Officer | Aug 14, 2019 | Sale | $39.49 | 6,252 | 246,891 | 19,193 | Aug 16, 2019, 04:15 PM |
| STACK DAVID M | CEO and Chairman | Jul 08, 2019 | Sale | $42.88 | 13,115 | 562,377 | 156,999 | Jul 10, 2019, 05:08 PM |
| STACK DAVID M | CEO and Chairman | Jun 11, 2019 | Option Exercise | $3.06 | 24,000 | 73,560 | 169,231 | Jun 13, 2019, 05:16 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 10, 2019 | Sale | $44.28 | 2,126 | 94,139 | 10,042 | Jun 12, 2019, 05:12 PM |
| WINSTON ROY | Chief Clinical Officer | Jun 04, 2019 | Sale | $42.91 | 722 | 30,981 | 16,539 | Jun 06, 2019, 05:08 PM |
| Williams Kristen Marie | CAO and General Counsel | Jun 04, 2019 | Sale | $42.91 | 2,529 | 108,519 | 19,845 | Jun 06, 2019, 05:06 PM |
| STACK DAVID M | CEO and Chairman | Jun 04, 2019 | Sale | $42.91 | 12,385 | 531,440 | 121,531 | Jun 06, 2019, 05:03 PM |
| Scranton Richard | Chief Scientific Officer | Jun 05, 2019 | Sale | $43.50 | 4,114 | 178,959 | 11,061 | Jun 06, 2019, 05:01 PM |
| Scranton Richard | Chief Scientific Officer | Jun 04, 2019 | Sale | $42.77 | 4,926 | 210,662 | 18,027 | Jun 06, 2019, 05:01 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 04, 2019 | Sale | $42.91 | 967 | 41,494 | 10,268 | Jun 06, 2019, 04:58 PM |
| Reinhart Charles A. III | Chief Financial Officer | Jun 04, 2019 | Sale | $42.91 | 1,106 | 47,458 | 11,936 | Jun 06, 2019, 04:55 PM |
| McLoughlin Dennis | Chief Commercial Officer | Jun 04, 2019 | Sale | $42.91 | 1,099 | 47,158 | 13,822 | Jun 06, 2019, 04:50 PM |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | Jun 04, 2019 | Sale | $42.91 | 430 | 18,451 | 5,367 | Jun 06, 2019, 04:44 PM |
| HASTINGS PAUL J | Director | Jun 04, 2019 | Sale | $42.66 | 782 | 33,360 | 2,747 | Jun 06, 2019, 04:39 PM |
| Scranton Richard | Chief Scientific Officer | Jun 03, 2019 | Option Exercise | $10.75 | 15,510 | 166,790 | 35,611 | Jun 05, 2019, 04:21 PM |
| Scranton Richard | Chief Scientific Officer | Jun 03, 2019 | Sale | $43.21 | 15,510 | 670,187 | 20,101 | Jun 05, 2019, 04:21 PM |
| Kronenfeld Mark A. | Director | Mar 06, 2019 | Buy | $38.97 | 1,700 | 66,244 | 10,277 | Mar 08, 2019, 04:17 PM |
| STACK DAVID M | CEO and Chairman | Dec 18, 2018 | Option Exercise | $3.55 | 12,000 | 42,600 | 133,683 | Dec 20, 2018, 04:30 PM |
| Wicki Andreas | Director | Dec 13, 2018 | Sale | $46.18 | 8,720 | 402,692 | 950,362 | Dec 14, 2018, 05:47 PM |
| Wicki Andreas | Director | Dec 12, 2018 | Sale | $47.84 | 5,807 | 277,803 | 959,082 | Dec 14, 2018, 05:47 PM |
| Wicki Andreas | Director | Nov 19, 2018 | Sale | $47.08 | 990 | 46,605 | 964,889 | Nov 21, 2018, 05:19 PM |
| PACE GARY W | Director | Nov 19, 2018 | Buy | $46.18 | 4,500 | 207,810 | 32,819 | Nov 21, 2018, 04:07 PM |
| Wicki Andreas | Director | Nov 16, 2018 | Sale | $46.83 | 25,600 | 1,198,775 | 969,379 | Nov 19, 2018, 07:17 PM |
| Wicki Andreas | Director | Nov 15, 2018 | Sale | $47.64 | 18,809 | 896,145 | 991,479 | Nov 19, 2018, 07:17 PM |
| Wicki Andreas | Director | Nov 15, 2018 | Sale | $47.63 | 26,089 | 1,242,666 | 1,010,288 | Nov 19, 2018, 07:17 PM |
| STACK DAVID M | CEO and Chairman | Nov 15, 2018 | Sale | $47.39 | 15,000 | 710,801 | 126,241 | Nov 19, 2018, 04:06 PM |
| Wicki Andreas | Director | Nov 12, 2018 | Sale | $49.83 | 5,478 | 272,980 | 1,036,377 | Nov 14, 2018, 08:09 PM |
| Wicki Andreas | Director | Nov 09, 2018 | Sale | $50.23 | 906 | 45,508 | 1,041,855 | Nov 13, 2018, 08:35 PM |
| Wicki Andreas | Director | Nov 08, 2018 | Sale | $51.13 | 57,339 | 2,931,583 | 1,042,761 | Nov 13, 2018, 08:35 PM |
| PACE GARY W | Director | Nov 07, 2018 | Buy | $51.29 | 4,000 | 205,160 | 28,319 | Nov 09, 2018, 04:30 PM |
| Riker Lauren Bullaro | Vice President, Finance | Nov 02, 2018 | Option Exercise | $10.34 | 1,000 | 10,340 | 11,474 | Nov 06, 2018, 04:25 PM |
| Riker Lauren Bullaro | Vice President, Finance | Nov 02, 2018 | Sale | $54.35 | 1,000 | 54,350 | 10,474 | Nov 06, 2018, 04:25 PM |
| STACK DAVID M | CEO and Chairman | Oct 11, 2018 | Option Exercise | $2.90 | 45,000 | 130,650 | 136,683 | Oct 15, 2018, 04:30 PM |
| Riker Lauren Bullaro | Vice President, Finance | Sep 24, 2018 | Option Exercise | $10.34 | 1,000 | 10,340 | 11,474 | Sep 26, 2018, 05:13 PM |
| Riker Lauren Bullaro | Vice President, Finance | Sep 24, 2018 | Sale | $50.70 | 1,000 | 50,700 | 10,474 | Sep 26, 2018, 05:13 PM |
| Kronenfeld Mark A. | Director | Aug 28, 2018 | Buy | $44.61 | 1,000 | 44,611 | 8,577 | Aug 30, 2018, 04:34 PM |
| Riker Lauren Bullaro | Vice President, Finance | Aug 22, 2018 | Sale | $44.48 | 1,667 | 74,148 | 10,474 | Aug 24, 2018, 04:59 PM |
| STACK DAVID M | CEO and Chairman | Aug 15, 2018 | Option Exercise | $10.58 | 14,091 | 149,079 | 124,745 | Aug 16, 2018, 05:14 PM |
| STACK DAVID M | CEO and Chairman | Aug 15, 2018 | Sale | $47.32 | 33,062 | 1,564,432 | 103,547 | Aug 16, 2018, 05:14 PM |
| Williams Kristen Marie | CAO and General Counsel | Aug 14, 2018 | Sale | $47.04 | 4,773 | 224,522 | 22,374 | Aug 16, 2018, 05:12 PM |
| STACK DAVID M | CEO and Chairman | Jun 07, 2018 | Sale | $36.87 | 9,791 | 360,984 | 84,640 | Jun 08, 2018, 05:03 PM |
| STACK DAVID M | CEO and Chairman | Jun 06, 2018 | Sale | $35.61 | 8,615 | 306,780 | 91,831 | Jun 08, 2018, 05:03 PM |
| Williams Kristen Marie | CAO and General Counsel | Jun 04, 2018 | Sale | $33.02 | 2,040 | 67,361 | 19,272 | Jun 06, 2018, 08:11 PM |
| Weiland Robert J. | Chief Commercial Officer | Jun 04, 2018 | Sale | $33.02 | 373 | 12,316 | 5,088 | Jun 06, 2018, 08:11 PM |
| Scranton Richard | Chief Scientific Officer | Jun 04, 2018 | Sale | $33.02 | 1,367 | 45,138 | 12,226 | Jun 06, 2018, 08:09 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 04, 2018 | Sale | $33.02 | 801 | 26,449 | 9,641 | Jun 06, 2018, 08:09 PM |
| Reinhart Charles A. III | Chief Financial Officer | Jun 04, 2018 | Sale | $33.02 | 708 | 23,378 | 8,042 | Jun 06, 2018, 08:08 PM |
| HASTINGS PAUL J | Director | Jun 04, 2018 | Sale | $33.90 | 771 | 26,137 | 2,747 | Jun 06, 2018, 08:07 PM |
| STACK DAVID M | CEO and Chairman | May 15, 2018 | Option Exercise | $7.62 | 25,000 | 190,450 | 125,446 | May 17, 2018, 07:17 PM |
| STACK DAVID M | CEO and Chairman | May 15, 2018 | Sale | $33.79 | 25,000 | 844,781 | 104,340 | May 17, 2018, 07:17 PM |
| STACK DAVID M | CEO and Chairman | Jan 10, 2018 | Option Exercise | $1.61 | 28,885 | 46,505 | 129,331 | Jan 12, 2018, 06:15 PM |
| STACK DAVID M | CEO and Chairman | Jan 10, 2018 | Sale | $40.19 | 28,885 | 1,160,975 | 105,959 | Jan 12, 2018, 06:15 PM |
| Riker Lauren Bullaro | Vice President, Finance | Dec 15, 2017 | Sale | $43.70 | 340 | 14,858 | 10,442 | Dec 18, 2017, 07:52 PM |
| Williams Kristen Marie | CAO and General Counsel | Nov 17, 2017 | Option Exercise | $25.37 | 7,857 | 199,332 | 29,169 | Nov 20, 2017, 06:44 PM |
| Williams Kristen Marie | CAO and General Counsel | Nov 16, 2017 | Option Exercise | $25.37 | 2,143 | 54,368 | 23,455 | Nov 20, 2017, 06:44 PM |
| Williams Kristen Marie | CAO and General Counsel | Nov 17, 2017 | Sale | $40.00 | 7,857 | 314,280 | 21,312 | Nov 20, 2017, 06:44 PM |
| Williams Kristen Marie | CAO and General Counsel | Nov 16, 2017 | Sale | $40.01 | 2,143 | 85,741 | 21,312 | Nov 20, 2017, 06:44 PM |
| Jones James B | SVP & Chief Medical Officer | Nov 20, 2017 | Sale | $41.11 | 850 | 34,942 | 16,823 | Nov 20, 2017, 06:43 PM |
| STACK DAVID M | CEO and Chairman | Nov 15, 2017 | Option Exercise | $1.61 | 28,885 | 46,505 | 159,164 | Nov 17, 2017, 05:15 PM |
| STACK DAVID M | CEO and Chairman | Nov 15, 2017 | Sale | $38.34 | 58,885 | 2,257,708 | 102,179 | Nov 17, 2017, 05:15 PM |
| Kronenfeld Mark A. | Director | Nov 10, 2017 | Buy | $41.60 | 1,000 | 41,603 | 6,795 | Nov 13, 2017, 08:03 PM |
| HASTINGS PAUL J | Director | Aug 22, 2017 | Sale | $36.15 | 1,044 | 37,741 | 3,518 | Aug 24, 2017, 08:30 PM |
| Williams Kristen Marie | CAO and General Counsel | Aug 15, 2017 | Sale | $36.75 | 3,461 | 127,192 | 21,312 | Aug 17, 2017, 06:56 PM |
| STACK DAVID M | CEO and Chairman | Aug 15, 2017 | Option Exercise | $1.61 | 28,885 | 46,505 | 159,164 | Aug 17, 2017, 06:55 PM |
| STACK DAVID M | CEO and Chairman | Aug 15, 2017 | Sale | $36.37 | 28,885 | 1,050,547 | 130,279 | Aug 17, 2017, 06:55 PM |
| Froimson Mark | Director | Aug 08, 2017 | Buy | $37.13 | 100 | 3,713 | 100 | Aug 16, 2017, 08:43 PM |
| STACK DAVID M | CEO and Chairman | Jul 24, 2017 | Option Exercise | $1.61 | 15,000 | 24,150 | 130,279 | Jul 26, 2017, 05:28 PM |
| STACK DAVID M | CEO and Chairman | Jun 23, 2017 | Option Exercise | $1.61 | 15,000 | 24,150 | 115,059 | Jun 27, 2017, 08:22 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 07, 2017 | Sale | $44.37 | 1,119 | 49,650 | 7,063 | Jun 09, 2017, 07:08 PM |
| Williams Kristen Marie | CAO and General Counsel | Jun 05, 2017 | Sale | $43.32 | 1,877 | 81,314 | 13,773 | Jun 07, 2017, 07:03 PM |
| STACK DAVID M | CEO and Chairman | Jun 05, 2017 | Sale | $43.32 | 4,311 | 186,757 | 59,559 | Jun 07, 2017, 07:02 PM |
| Scibetta James S | President | Jun 05, 2017 | Sale | $43.32 | 1,966 | 85,169 | 25,118 | Jun 07, 2017, 07:00 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 05, 2017 | Sale | $43.32 | 601 | 26,036 | 8,182 | Jun 07, 2017, 06:59 PM |
| Jones James B | SVP & Chief Medical Officer | Jun 05, 2017 | Sale | $43.32 | 767 | 33,227 | 9,813 | Jun 07, 2017, 06:58 PM |
| Braunstein Scott | SVP, Strategy & Corp. Dev. | Jun 05, 2017 | Sale | $43.32 | 768 | 33,271 | 9,982 | Jun 07, 2017, 06:57 PM |
| Williams Kristen Marie | CAO and General Counsel | May 15, 2017 | Option Exercise | $10.50 | 21,041 | 220,856 | 36,691 | May 17, 2017, 06:45 PM |
| Williams Kristen Marie | CAO and General Counsel | May 15, 2017 | Sale | $50.86 | 21,041 | 1,070,145 | 15,650 | May 17, 2017, 06:45 PM |
| Scibetta James S | President | May 15, 2017 | Option Exercise | $5.49 | 20,000 | 109,800 | 47,084 | May 17, 2017, 06:44 PM |
| Scibetta James S | President | May 15, 2017 | Sale | $51.20 | 20,000 | 1,024,000 | 27,084 | May 17, 2017, 06:44 PM |
| Scibetta James S | President | Jan 17, 2017 | Option Exercise | $5.03 | 20,000 | 100,593 | 47,084 | Jan 19, 2017, 06:50 PM |
| Scibetta James S | President | Jan 17, 2017 | Sale | $38.53 | 20,000 | 770,698 | 32,081 | Jan 19, 2017, 06:50 PM |
| STACK DAVID M | CEO and Chairman | Jan 17, 2017 | Option Exercise | $5.49 | 15,000 | 82,350 | 78,870 | Jan 19, 2017, 06:47 PM |
| STACK DAVID M | CEO and Chairman | Jan 17, 2017 | Sale | $38.41 | 15,000 | 576,122 | 65,170 | Jan 19, 2017, 06:47 PM |
| STACK DAVID M | CEO and Chairman | Nov 15, 2016 | Option Exercise | $5.49 | 15,000 | 82,350 | 78,637 | Nov 17, 2016, 05:41 PM |
| STACK DAVID M | CEO and Chairman | Nov 15, 2016 | Sale | $37.28 | 15,000 | 559,140 | 65,437 | Nov 17, 2016, 05:41 PM |
| Scibetta James S | President | Nov 15, 2016 | Option Exercise | $1.61 | 20,000 | 32,200 | 47,084 | Nov 17, 2016, 05:41 PM |
| Scibetta James S | President | Nov 15, 2016 | Sale | $36.50 | 20,000 | 730,000 | 27,084 | Nov 17, 2016, 05:41 PM |
| STACK DAVID M | CEO and Chairman | Oct 05, 2016 | Option Exercise | $1.61 | 30,000 | 48,300 | 63,637 | Oct 07, 2016, 05:47 PM |
| STACK DAVID M | CEO and Chairman | Aug 15, 2016 | Option Exercise | $5.49 | 15,000 | 82,350 | 48,637 | Aug 17, 2016, 07:46 PM |
| STACK DAVID M | CEO and Chairman | Aug 15, 2016 | Sale | $45.32 | 15,000 | 679,800 | 33,637 | Aug 17, 2016, 07:46 PM |
| Scibetta James S | President | Aug 15, 2016 | Option Exercise | $1.61 | 25,000 | 40,250 | 52,084 | Aug 17, 2016, 07:45 PM |
| Scibetta James S | President | Aug 15, 2016 | Sale | $45.21 | 25,000 | 1,130,250 | 27,084 | Aug 17, 2016, 07:45 PM |
| Williams Kristen Marie | CAO and General Counsel | Jun 06, 2016 | Sale | $47.20 | 600 | 28,319 | 6,900 | Jun 08, 2016, 07:06 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 07, 2016 | Sale | $47.90 | 617 | 29,555 | 5,845 | Jun 08, 2016, 07:05 PM |
| Riker Lauren Bullaro | Vice President, Finance | Jun 06, 2016 | Sale | $47.20 | 321 | 15,151 | 5,945 | Jun 08, 2016, 07:05 PM |
| Kronenfeld Mark A. | Director | Jun 06, 2016 | Sale | $46.95 | 900 | 42,255 | 2,950 | Jun 08, 2016, 07:04 PM |
| Brege Laura | Director | Jun 06, 2016 | Sale | $46.95 | 1,000 | 46,950 | 1,000 | Jun 08, 2016, 07:04 PM |
| HASTINGS PAUL J | Director | Jun 06, 2016 | Sale | $46.95 | 1,136 | 53,335 | 1,717 | Jun 08, 2016, 07:02 PM |
| STACK DAVID M | CEO and Chairman | Apr 15, 2016 | Option Exercise | $5.49 | 25,000 | 137,250 | 25,285 | Apr 19, 2016, 09:29 PM |
| STACK DAVID M | CEO and Chairman | Apr 15, 2016 | Sale | $64.14 | 25,000 | 1,603,378 | 6,635 | Apr 19, 2016, 09:29 PM |
| HASTINGS PAUL J | Director | Feb 17, 2016 | Option Exercise | $12.92 | 3,000 | 38,770 | 5,853 | Feb 22, 2016, 07:38 PM |
| HASTINGS PAUL J | Director | Feb 17, 2016 | Sale | $60.00 | 3,000 | 180,000 | 2,853 | Feb 22, 2016, 07:38 PM |
| Braunstein Scott | SVP, Strategy & Corp. Dev. | Jan 29, 2016 | Buy | $58.92 | 2,000 | 117,840 | 2,000 | Feb 01, 2016, 07:27 PM |
| Jones James B | SVP & Chief Medical Officer | Jan 27, 2016 | Buy | $62.50 | 500 | 31,250 | 1,500 | Jan 29, 2016, 06:45 PM |
| LONGENECKER JOHN P PHD | Director | Jan 12, 2016 | Buy | $66.55 | 300 | 19,965 | 2,300 | Jan 14, 2016, 07:37 PM |
| Jones James B | SVP & Chief Medical Officer | Jan 12, 2016 | Buy | $66.00 | 1,000 | 66,000 | 1,000 | Jan 14, 2016, 07:36 PM |
| HASTINGS PAUL J | Director | Nov 20, 2015 | Option Exercise | $10.81 | 3,000 | 32,430 | 5,853 | Nov 24, 2015, 06:32 PM |
| HASTINGS PAUL J | Director | Nov 20, 2015 | Sale | $60.00 | 3,000 | 180,000 | 2,853 | Nov 24, 2015, 06:32 PM |
| STACK DAVID M | President, CEO and Chairman | Oct 15, 2015 | Option Exercise | $1.61 | 15,000 | 24,150 | 15,176 | Oct 19, 2015, 06:20 PM |
| STACK DAVID M | President, CEO and Chairman | Oct 15, 2015 | Sale | $37.57 | 15,000 | 563,561 | 8,575 | Oct 19, 2015, 06:20 PM |
| Scibetta James S | SVP, Chief Financial Officer | Sep 11, 2015 | Buy | $61.37 | 5,000 | 306,850 | 10,504 | Sep 14, 2015, 05:59 PM |
| HASTINGS PAUL J | Director | Aug 17, 2015 | Option Exercise | $10.81 | 3,000 | 32,430 | 5,853 | Aug 19, 2015, 08:26 PM |
| HASTINGS PAUL J | Director | Aug 17, 2015 | Sale | $60.02 | 3,000 | 180,060 | 2,853 | Aug 19, 2015, 08:26 PM |
| STACK DAVID M | President, CEO and Chairman | Jul 15, 2015 | Option Exercise | $1.61 | 15,000 | 24,150 | 15,176 | Jul 17, 2015, 07:09 PM |
| STACK DAVID M | President, CEO and Chairman | Jul 15, 2015 | Sale | $67.78 | 15,000 | 1,016,700 | 176 | Jul 17, 2015, 07:09 PM |
| STACK DAVID M | President, CEO and Chairman | Apr 15, 2015 | Option Exercise | $1.61 | 25,000 | 40,250 | 25,059 | Apr 17, 2015, 06:35 PM |
| STACK DAVID M | President, CEO and Chairman | Apr 15, 2015 | Sale | $90.50 | 25,000 | 2,262,475 | 59 | Apr 17, 2015, 06:35 PM |
| HASTINGS PAUL J | Director | Apr 10, 2015 | Option Exercise | $13.98 | 2,500 | 34,950 | 3,353 | Apr 14, 2015, 06:50 PM |
| HASTINGS PAUL J | Director | Apr 10, 2015 | Sale | $88.00 | 2,500 | 220,000 | 853 | Apr 14, 2015, 06:50 PM |
| Markvicka Taunia | SVP, Chief Commercial Officer | Mar 17, 2015 | Option Exercise | $5.49 | 8,349 | 45,836 | 8,579 | Mar 19, 2015, 06:59 PM |
| Riker Lauren Bullaro | Executive Director, Finance | Mar 16, 2015 | Option Exercise | $10.34 | 5,000 | 51,700 | 7,230 | Mar 18, 2015, 08:02 PM |
| Riker Lauren Bullaro | Executive Director, Finance | Mar 16, 2015 | Sale | $95.34 | 5,000 | 476,700 | 2,230 | Mar 18, 2015, 08:02 PM |
| PACE GARY W | Director | Mar 13, 2015 | Buy | $93.83 | 1,000 | 93,830 | 18,692 | Mar 17, 2015, 08:06 PM |
| LONGENECKER JOHN P PHD | Director | Mar 12, 2015 | Option Exercise | $29.90 | 3,000 | 89,700 | 3,000 | Mar 16, 2015, 08:08 PM |
| LONGENECKER JOHN P PHD | Director | Mar 12, 2015 | Sale | $95.28 | 3,000 | 285,840 | 0 | Mar 16, 2015, 08:08 PM |
| Scibetta James S | SVP, Chief Financial Officer | Feb 06, 2015 | Option Exercise | $1.61 | 15,000 | 24,150 | 20,230 | Feb 09, 2015, 09:13 PM |
| Scibetta James S | SVP, Chief Financial Officer | Feb 06, 2015 | Sale | $111.22 | 15,000 | 1,668,374 | 15,937 | Feb 09, 2015, 09:13 PM |
| STACK DAVID M | President, CEO and Chairman | Jan 15, 2015 | Option Exercise | $1.61 | 15,000 | 24,150 | 16,267 | Jan 20, 2015, 09:12 PM |
| STACK DAVID M | President, CEO and Chairman | Jan 15, 2015 | Sale | $97.52 | 15,000 | 1,462,829 | 5,367 | Jan 20, 2015, 09:12 PM |
| HASTINGS PAUL J | Director | Jan 12, 2015 | Option Exercise | $13.98 | 2,500 | 34,950 | 3,353 | Jan 14, 2015, 04:12 PM |
| HASTINGS PAUL J | Director | Jan 12, 2015 | Sale | $94.06 | 2,500 | 235,150 | 853 | Jan 14, 2015, 04:12 PM |
| LONGENECKER JOHN P PHD | Director | Dec 29, 2014 | Option Exercise | $29.90 | 1,000 | 29,900 | 1,000 | Dec 30, 2014, 07:21 PM |
| LONGENECKER JOHN P PHD | Director | Dec 29, 2014 | Sale | $93.32 | 1,000 | 93,320 | 0 | Dec 30, 2014, 07:21 PM |
| WINGER DENNIS L | Director | Dec 05, 2014 | Buy | $94.54 | 2,645 | 250,058 | 2,645 | Dec 08, 2014, 07:29 PM |
| Scibetta James S | SVP, Chief Financial Officer | Nov 07, 2014 | Option Exercise | $1.61 | 15,000 | 24,150 | 20,000 | Nov 12, 2014, 07:57 PM |
| Scibetta James S | SVP, Chief Financial Officer | Nov 07, 2014 | Sale | $87.18 | 15,000 | 1,307,642 | 17,700 | Nov 12, 2014, 07:57 PM |
| Markvicka Taunia | SVP, Chief Commercial Officer | Nov 07, 2014 | Buy | $86.62 | 230 | 19,923 | 230 | Nov 12, 2014, 07:56 PM |
| Kronenfeld Mark A. | Director | Nov 03, 2014 | Buy | $90.48 | 850 | 76,908 | 1,850 | Nov 04, 2014, 07:42 PM |
| STACK DAVID M | President, CEO and Chairman | Oct 15, 2014 | Option Exercise | $1.61 | 15,000 | 24,150 | 16,208 | Oct 17, 2014, 06:37 PM |
| STACK DAVID M | President, CEO and Chairman | Oct 15, 2014 | Sale | $99.49 | 15,000 | 1,492,418 | 15,908 | Oct 17, 2014, 06:37 PM |
| HASTINGS PAUL J | Director | Oct 10, 2014 | Option Exercise | $13.98 | 2,500 | 34,950 | 3,353 | Oct 14, 2014, 08:24 PM |
| HASTINGS PAUL J | Director | Oct 10, 2014 | Sale | $94.87 | 2,500 | 237,175 | 853 | Oct 14, 2014, 08:24 PM |
| LONGENECKER JOHN P PHD | Director | Sep 29, 2014 | Option Exercise | $29.90 | 1,000 | 29,900 | 1,000 | Sep 30, 2014, 08:03 PM |
| LONGENECKER JOHN P PHD | Director | Sep 29, 2014 | Sale | $96.40 | 1,000 | 96,400 | 0 | Sep 30, 2014, 08:03 PM |
| Wicki Andreas | Director | Aug 29, 2014 | Sale | $108.15 | 10,481 | 1,133,562 | 1,100,100 | Sep 02, 2014, 08:41 PM |
| Wicki Andreas | Director | Aug 28, 2014 | Sale | $108.06 | 11,013 | 1,190,098 | 1,110,581 | Sep 02, 2014, 08:41 PM |
| Wicki Andreas | Director | Aug 26, 2014 | Sale | $108.11 | 24,207 | 2,617,019 | 1,123,200 | Aug 27, 2014, 08:44 PM |
| Wicki Andreas | Director | Aug 25, 2014 | Sale | $108.07 | 30,000 | 3,241,980 | 1,147,407 | Aug 27, 2014, 08:44 PM |
| Wicki Andreas | Director | Aug 27, 2014 | Sale | $108.05 | 1,606 | 173,535 | 1,121,594 | Aug 27, 2014, 08:44 PM |
| Wicki Andreas | Director | Aug 11, 2014 | Sale | $101.82 | 37,786 | 3,847,484 | 1,177,407 | Aug 12, 2014, 03:04 PM |
| Wicki Andreas | Director | Aug 11, 2014 | Sale | $101.20 | 30,114 | 3,047,416 | 1,215,193 | Aug 12, 2014, 03:04 PM |
| Wicki Andreas | Director | Aug 08, 2014 | Sale | $101.00 | 82,100 | 8,292,100 | 1,245,307 | Aug 12, 2014, 03:04 PM |
| Scibetta James S | SVP, Chief Financial Officer | Aug 08, 2014 | Option Exercise | $1.61 | 15,000 | 24,150 | 20,000 | Aug 11, 2014, 07:33 PM |
| Scibetta James S | SVP, Chief Financial Officer | Aug 08, 2014 | Sale | $99.63 | 15,000 | 1,494,400 | 15,000 | Aug 11, 2014, 07:33 PM |
| PATOU GARY | Chief Medical Officer | Aug 07, 2014 | Option Exercise | $10.16 | 20,000 | 203,258 | 20,000 | Aug 08, 2014, 04:31 PM |
| PATOU GARY | Chief Medical Officer | Aug 07, 2014 | Sale | $100.26 | 20,000 | 2,005,200 | 0 | Aug 08, 2014, 04:31 PM |
| STACK DAVID M | President, CEO and Chairman | Jul 15, 2014 | Option Exercise | $1.61 | 15,000 | 24,150 | 16,208 | Jul 16, 2014, 06:31 PM |
| STACK DAVID M | President, CEO and Chairman | Jul 15, 2014 | Sale | $86.75 | 15,000 | 1,301,232 | 8,808 | Jul 16, 2014, 06:31 PM |
| PATOU GARY | Chief Medical Officer | Jul 14, 2014 | Option Exercise | $6.47 | 30,000 | 194,007 | 30,000 | Jul 15, 2014, 02:10 PM |
| PATOU GARY | Chief Medical Officer | Jul 14, 2014 | Sale | $86.96 | 29,700 | 2,582,639 | 2,407 | Jul 15, 2014, 02:10 PM |
| HASTINGS PAUL J | Director | Jul 10, 2014 | Option Exercise | $13.98 | 2,500 | 34,950 | 3,353 | Jul 11, 2014, 08:26 PM |
| HASTINGS PAUL J | Director | Jul 10, 2014 | Sale | $84.41 | 2,500 | 211,017 | 2,753 | Jul 11, 2014, 08:26 PM |
| LONGENECKER JOHN P PHD | Director | Jun 30, 2014 | Option Exercise | $29.90 | 1,000 | 29,900 | 1,000 | Jul 02, 2014, 06:26 PM |
| LONGENECKER JOHN P PHD | Director | Jun 30, 2014 | Sale | $91.60 | 1,000 | 91,600 | 0 | Jul 02, 2014, 06:26 PM |
| Wicki Andreas | Director | Jun 09, 2014 | Sale | $85.43 | 68,000 | 5,809,185 | 1,370,349 | Jun 11, 2014, 06:01 PM |
| Wicki Andreas | Director | Jun 04, 2014 | Sale | $82.40 | 4,500 | 370,809 | 1,458,807 | Jun 06, 2014, 07:23 PM |
| Wicki Andreas | Director | Jun 06, 2014 | Sale | $82.71 | 40,200 | 3,324,753 | 1,395,407 | Jun 06, 2014, 07:23 PM |
| Wicki Andreas | Director | Jun 05, 2014 | Sale | $82.53 | 23,200 | 1,914,668 | 1,435,607 | Jun 06, 2014, 07:23 PM |
| Wicki Andreas | Director | Jun 03, 2014 | Sale | $80.72 | 57,400 | 4,633,208 | 1,463,307 | Jun 03, 2014, 08:48 PM |
| Wicki Andreas | Director | Jun 02, 2014 | Sale | $80.52 | 10,600 | 853,498 | 1,520,707 | Jun 03, 2014, 08:48 PM |
| Wicki Andreas | Director | May 27, 2014 | Sale | $77.93 | 64,400 | 5,018,750 | 1,531,307 | May 28, 2014, 09:31 PM |
| Wicki Andreas | Director | May 21, 2014 | Sale | $77.80 | 3,600 | 280,086 | 1,595,707 | May 22, 2014, 09:30 PM |
| PATOU GARY | Chief Medical Officer | May 09, 2014 | Option Exercise | $2.94 | 20,000 | 58,724 | 20,000 | May 13, 2014, 06:46 PM |
| PATOU GARY | Chief Medical Officer | May 12, 2014 | Option Exercise | $5.49 | 10,000 | 54,900 | 10,000 | May 13, 2014, 06:46 PM |
| PATOU GARY | Chief Medical Officer | May 12, 2014 | Sale | $75.00 | 10,000 | 750,000 | 0 | May 13, 2014, 06:46 PM |
| PATOU GARY | Chief Medical Officer | May 09, 2014 | Sale | $74.08 | 20,000 | 1,481,600 | 0 | May 13, 2014, 06:46 PM |
| Wicki Andreas | Director | May 08, 2014 | Sale | $75.76 | 23,220 | 1,759,215 | 1,599,307 | May 12, 2014, 07:55 PM |
| STACK DAVID M | President, CEO and Chairman | May 09, 2014 | Option Exercise | $1.61 | 25,000 | 40,250 | 26,208 | May 09, 2014, 08:30 PM |
| STACK DAVID M | President, CEO and Chairman | May 09, 2014 | Sale | $73.94 | 25,000 | 1,848,395 | 18,808 | May 09, 2014, 08:30 PM |
| Brege Laura | Director | May 09, 2014 | Option Exercise | $11.76 | 10,000 | 117,610 | 10,000 | May 09, 2014, 08:29 PM |
| Brege Laura | Director | May 09, 2014 | Sale | $73.84 | 10,000 | 738,450 | 2,500 | May 09, 2014, 08:29 PM |
| Scibetta James S | SVP, Chief Financial Officer | May 08, 2014 | Option Exercise | $1.61 | 15,000 | 24,150 | 20,000 | May 09, 2014, 08:27 PM |
| Scibetta James S | SVP, Chief Financial Officer | May 08, 2014 | Sale | $75.05 | 15,000 | 1,125,681 | 16,700 | May 09, 2014, 08:27 PM |
| Wicki Andreas | Director | May 07, 2014 | Sale | $75.64 | 600 | 45,386 | 1,622,527 | May 07, 2014, 08:40 PM |
| Wicki Andreas | Director | May 06, 2014 | Sale | $75.78 | 44,180 | 3,348,062 | 1,623,127 | May 07, 2014, 08:40 PM |
| LONGENECKER JOHN P PHD | Director | Mar 28, 2014 | Option Exercise | $29.90 | 1,000 | 29,900 | 1,000 | Mar 31, 2014, 08:08 PM |
| LONGENECKER JOHN P PHD | Director | Mar 28, 2014 | Sale | $64.63 | 1,000 | 64,630 | 0 | Mar 31, 2014, 08:08 PM |
| Wicki Andreas | Director | Mar 06, 2014 | Sale | $80.11 | 2,200 | 176,244 | 1,667,307 | Mar 06, 2014, 09:09 PM |
| Wicki Andreas | Director | Mar 05, 2014 | Sale | $80.16 | 22,687 | 1,818,651 | 1,669,507 | Mar 06, 2014, 09:09 PM |
| STACK DAVID M | President and CEO | Dec 30, 2013 | Option Exercise | $1.61 | 15,000 | 24,150 | 17,987 | Jan 02, 2014, 04:39 PM |
| STACK DAVID M | President and CEO | Dec 30, 2013 | Sale | $55.84 | 15,000 | 837,559 | 2,987 | Jan 02, 2014, 04:39 PM |
| LONGENECKER JOHN P PHD | Director | Dec 30, 2013 | Option Exercise | $1.61 | 2,500 | 4,025 | 2,500 | Jan 02, 2014, 04:39 PM |
| LONGENECKER JOHN P PHD | Director | Dec 30, 2013 | Sale | $55.55 | 2,500 | 138,875 | 0 | Jan 02, 2014, 04:39 PM |
| Scibetta James S | Chief Financial Officer | Dec 30, 2013 | Option Exercise | $1.61 | 10,000 | 16,100 | 15,000 | Jan 02, 2014, 04:38 PM |
| Scibetta James S | Chief Financial Officer | Dec 30, 2013 | Sale | $55.55 | 10,000 | 555,500 | 5,000 | Jan 02, 2014, 04:38 PM |
| Markvicka Taunia | Vice President, Commercial | Nov 06, 2013 | Option Exercise | $10.81 | 50,000 | 540,500 | 50,000 | Nov 08, 2013, 07:17 PM |
| Markvicka Taunia | Vice President, Commercial | Nov 06, 2013 | Sale | $51.14 | 50,000 | 2,556,980 | 21,606 | Nov 08, 2013, 07:17 PM |
| PATOU GARY | Chief Medical Officer | Oct 01, 2013 | Option Exercise | $1.61 | 20,000 | 32,200 | 20,000 | Oct 04, 2013, 04:57 PM |
| PATOU GARY | Chief Medical Officer | Oct 01, 2013 | Sale | $48.92 | 20,000 | 978,400 | 0 | Oct 04, 2013, 04:57 PM |
| Scibetta James S | Chief Financial Officer | Sep 30, 2013 | Option Exercise | $1.61 | 10,000 | 16,100 | 15,000 | Oct 02, 2013, 07:10 PM |
| Scibetta James S | Chief Financial Officer | Sep 30, 2013 | Sale | $46.74 | 10,000 | 467,400 | 5,000 | Oct 02, 2013, 07:10 PM |
| LONGENECKER JOHN P PHD | Director | Sep 30, 2013 | Option Exercise | $1.61 | 2,500 | 4,025 | 2,500 | Oct 02, 2013, 07:09 PM |
| LONGENECKER JOHN P PHD | Director | Sep 30, 2013 | Sale | $46.74 | 2,500 | 116,850 | 0 | Oct 02, 2013, 07:09 PM |
| STACK DAVID M | President and CEO | Sep 30, 2013 | Option Exercise | $1.61 | 15,000 | 24,150 | 17,573 | Oct 02, 2013, 07:09 PM |
| STACK DAVID M | President and CEO | Sep 30, 2013 | Sale | $47.05 | 15,000 | 705,741 | 3,667 | Oct 02, 2013, 07:09 PM |
| Markvicka Taunia | Vice President, Commercial | Sep 25, 2013 | Option Exercise | $5.49 | 10,000 | 54,900 | 10,000 | Sep 27, 2013, 06:11 PM |
| Markvicka Taunia | Vice President, Commercial | Sep 25, 2013 | Sale | $47.00 | 10,000 | 470,000 | 0 | Sep 27, 2013, 06:11 PM |
| Kronenfeld Mark A. | Director | Sep 11, 2013 | Buy | $37.01 | 1,000 | 37,010 | 1,000 | Sep 13, 2013, 07:26 PM |
| Wicki Andreas | Director | Sep 11, 2013 | Sale | $37.25 | 2,686 | 100,054 | 1,665,450 | Sep 12, 2013, 09:41 PM |
| Wicki Andreas | Director | Sep 11, 2013 | Sale | $37.25 | 15,097 | 562,363 | 1,692,194 | Sep 12, 2013, 09:41 PM |
| Wicki Andreas | Director | Sep 11, 2013 | Option Exercise | $8.38 | 79,033 | 662,390 | 1,707,291 | Sep 12, 2013, 09:41 PM |
| Markvicka Taunia | Vice President, Commercial | Aug 14, 2013 | Option Exercise | $1.61 | 14,700 | 23,667 | 14,700 | Aug 16, 2013, 04:29 PM |
| Markvicka Taunia | Vice President, Commercial | Aug 14, 2013 | Sale | $37.00 | 14,700 | 543,900 | 0 | Aug 16, 2013, 04:29 PM |
| Wicki Andreas | Director | Jul 22, 2013 | Sale | $35.28 | 19,938 | 703,508 | 1,630,944 | Jul 23, 2013, 07:50 PM |
| Wicki Andreas | Director | Jul 19, 2013 | Sale | $34.98 | 56,020 | 1,959,524 | 1,650,882 | Jul 23, 2013, 07:50 PM |
| Wicki Andreas | Director | Jul 18, 2013 | Sale | $34.80 | 4,042 | 140,662 | 1,706,902 | Jul 19, 2013, 05:55 PM |
| Wicki Andreas | Director | Jul 17, 2013 | Sale | $33.20 | 21,518 | 714,398 | 1,710,944 | Jul 19, 2013, 05:55 PM |
| Wicki Andreas | Director | Jul 16, 2013 | Sale | $33.20 | 350 | 11,620 | 1,732,462 | Jul 17, 2013, 08:23 PM |
| Wicki Andreas | Director | Jul 15, 2013 | Sale | $33.28 | 48,132 | 1,601,833 | 1,732,812 | Jul 17, 2013, 08:23 PM |
| Wicki Andreas | Director | Jul 11, 2013 | Sale | $31.48 | 80,000 | 2,518,416 | 1,780,944 | Jul 15, 2013, 05:50 PM |
| Markvicka Taunia | Vice President, Commercial | Jul 12, 2013 | Option Exercise | $1.61 | 29,754 | 47,904 | 29,754 | Jul 15, 2013, 10:53 AM |
| Markvicka Taunia | Vice President, Commercial | Jul 12, 2013 | Sale | $32.00 | 29,754 | 952,128 | 0 | Jul 15, 2013, 10:53 AM |
| Wicki Andreas | Director | Jul 05, 2013 | Sale | $30.80 | 44,021 | 1,355,961 | 1,860,944 | Jul 09, 2013, 08:02 PM |
| Wicki Andreas | Director | Jul 03, 2013 | Sale | $30.67 | 50,000 | 1,533,300 | 1,904,965 | Jul 03, 2013, 06:31 PM |
| Wicki Andreas | Director | Jul 02, 2013 | Sale | $29.85 | 60,597 | 1,808,820 | 1,954,965 | Jul 03, 2013, 06:31 PM |
| Wicki Andreas | Director | Jul 01, 2013 | Sale | $29.85 | 3,851 | 114,952 | 2,015,562 | Jul 03, 2013, 06:31 PM |
| LONGENECKER JOHN P PHD | Director | Jun 28, 2013 | Option Exercise | $1.61 | 2,000 | 3,220 | 2,000 | Jul 02, 2013, 05:56 PM |
| LONGENECKER JOHN P PHD | Director | Jun 28, 2013 | Sale | $28.09 | 2,000 | 56,178 | 0 | Jul 02, 2013, 05:56 PM |
| Scibetta James S | Chief Financial Officer | Jun 28, 2013 | Option Exercise | $1.61 | 10,000 | 16,100 | 15,000 | Jul 02, 2013, 05:56 PM |
| Scibetta James S | Chief Financial Officer | Jun 28, 2013 | Sale | $28.05 | 10,000 | 280,460 | 5,000 | Jul 02, 2013, 05:56 PM |
| STACK DAVID M | President and CEO | Jun 28, 2013 | Option Exercise | $1.61 | 15,000 | 24,150 | 17,573 | Jul 02, 2013, 05:56 PM |
| STACK DAVID M | President and CEO | Jun 28, 2013 | Sale | $28.73 | 15,000 | 430,967 | 2,573 | Jul 02, 2013, 05:56 PM |
| PATOU GARY | Chief Medical Officer | Jul 02, 2013 | Option Exercise | $1.61 | 10,000 | 16,100 | 10,000 | Jul 02, 2013, 04:47 PM |
| PATOU GARY | Chief Medical Officer | Jul 01, 2013 | Option Exercise | $1.61 | 30,000 | 48,300 | 30,000 | Jul 02, 2013, 04:47 PM |
| PATOU GARY | Chief Medical Officer | Jul 01, 2013 | Sale | $29.25 | 30,000 | 877,500 | 0 | Jul 02, 2013, 04:47 PM |
| PATOU GARY | Chief Medical Officer | Jul 02, 2013 | Sale | $30.00 | 10,000 | 300,000 | 0 | Jul 02, 2013, 04:47 PM |
| MIDDLETON FRED A | Director | Jun 24, 2013 | Sale | $28.70 | 5,900 | 169,330 | 0 | Jun 25, 2013, 09:03 PM |
| MIDDLETON FRED A | Director | Jun 21, 2013 | Sale | $29.17 | 70,000 | 2,041,713 | 8,728 | Jun 25, 2013, 09:03 PM |
| Wicki Andreas | Director | Jun 19, 2013 | Sale | $29.90 | 35,407 | 1,058,726 | 2,019,413 | Jun 21, 2013, 07:48 PM |
| MIDDLETON FRED A | Director | Jun 20, 2013 | Sale | $28.93 | 66,100 | 1,912,273 | 30,798 | Jun 20, 2013, 09:29 PM |
| MIDDLETON FRED A | Director | Jun 19, 2013 | Sale | $29.76 | 48,400 | 1,440,384 | 96,898 | Jun 20, 2013, 09:29 PM |
| MIDDLETON FRED A | Director | Jun 18, 2013 | Sale | $29.48 | 29,600 | 872,608 | 145,298 | Jun 20, 2013, 09:29 PM |
| Wicki Andreas | Director | Jun 17, 2013 | Sale | $29.86 | 50,145 | 1,497,224 | 2,054,820 | Jun 19, 2013, 05:59 PM |
| Pratt John | General Manager, San Diego | Jun 13, 2013 | Option Exercise | $10.62 | 20,107 | 213,457 | 18,232 | Jun 14, 2013, 06:29 PM |
| Pratt John | General Manager, San Diego | Jun 12, 2013 | Option Exercise | $10.81 | 925 | 9,999 | 925 | Jun 14, 2013, 06:29 PM |
| Pratt John | General Manager, San Diego | Jun 13, 2013 | Sale | $30.00 | 20,107 | 603,210 | 0 | Jun 14, 2013, 06:29 PM |
| Pratt John | General Manager, San Diego | Jun 12, 2013 | Sale | $30.00 | 925 | 27,750 | 0 | Jun 14, 2013, 06:29 PM |
| Wicki Andreas | Director | Jun 12, 2013 | Sale | $30.00 | 4,409 | 132,270 | 2,104,965 | Jun 14, 2013, 06:26 PM |
| EVNIN LUKE | Director | Jun 12, 2013 | Sale | $30.00 | 2,435 | 73,050 | 20,311 | Jun 13, 2013, 03:52 PM |
| EVNIN LUKE | Director | Jun 13, 2013 | Sale | $30.07 | 20,311 | 610,843 | 0 | Jun 13, 2013, 03:52 PM |
| Wicki Andreas | Director | Jun 11, 2013 | Sale | $30.00 | 9,000 | 270,000 | 2,109,374 | Jun 12, 2013, 08:30 PM |
| Wicki Andreas | Director | Jun 10, 2013 | Sale | $30.00 | 2,500 | 75,000 | 2,118,374 | Jun 12, 2013, 08:30 PM |
| Pratt John | General Manager, San Diego | Jun 10, 2013 | Option Exercise | $10.81 | 5,398 | 58,352 | 5,398 | Jun 12, 2013, 07:30 PM |
| Pratt John | General Manager, San Diego | Jun 11, 2013 | Option Exercise | $10.81 | 12,945 | 139,935 | 12,945 | Jun 12, 2013, 07:30 PM |
| Pratt John | General Manager, San Diego | Jun 10, 2013 | Sale | $30.00 | 5,398 | 161,940 | 0 | Jun 12, 2013, 07:30 PM |
| Pratt John | General Manager, San Diego | Jun 11, 2013 | Sale | $30.00 | 12,945 | 388,350 | 0 | Jun 12, 2013, 07:30 PM |
| Wicki Andreas | Director | Jun 05, 2013 | Sale | $30.00 | 2,500 | 75,000 | 2,120,874 | Jun 06, 2013, 08:00 PM |
| Wicki Andreas | Director | Jun 04, 2013 | Sale | $30.31 | 13,000 | 394,030 | 2,123,374 | Jun 06, 2013, 08:00 PM |
| Wicki Andreas | Director | Jun 03, 2013 | Sale | $30.00 | 1,900 | 57,000 | 2,136,374 | Jun 05, 2013, 08:40 PM |
| EVNIN LUKE | Director | Jun 03, 2013 | Sale | $30.00 | 82,072 | 2,462,160 | 824,255 | Jun 04, 2013, 12:41 PM |
| EVNIN LUKE | Director | May 31, 2013 | Sale | $30.00 | 9,935 | 298,050 | 906,327 | Jun 03, 2013, 04:04 PM |
| EVNIN LUKE | Director | May 30, 2013 | Sale | $30.00 | 44,582 | 1,337,460 | 916,262 | Jun 03, 2013, 04:04 PM |
| Wicki Andreas | Director | May 31, 2013 | Sale | $30.00 | 3,033 | 90,990 | 2,138,274 | May 31, 2013, 08:27 PM |
| Wicki Andreas | Director | May 30, 2013 | Sale | $30.00 | 2,500 | 75,000 | 2,141,307 | May 31, 2013, 08:27 PM |
| EVNIN LUKE | Director | May 28, 2013 | Sale | $30.95 | 195,117 | 6,039,523 | 1,061,535 | May 30, 2013, 02:47 PM |
| EVNIN LUKE | Director | May 29, 2013 | Sale | $30.00 | 20,411 | 612,330 | 960,844 | May 30, 2013, 02:47 PM |
| Wicki Andreas | Director | May 22, 2013 | Sale | $30.00 | 18,471 | 554,130 | 2,143,807 | May 24, 2013, 06:42 PM |
| EVNIN LUKE | Director | May 22, 2013 | Sale | $30.00 | 7,340 | 220,200 | 1,176,372 | May 23, 2013, 05:48 PM |
| Wicki Andreas | Director | May 20, 2013 | Sale | $30.00 | 14,374 | 431,220 | 2,162,278 | May 22, 2013, 07:41 PM |
| EVNIN LUKE | Director | May 20, 2013 | Sale | $30.00 | 13,550 | 406,500 | 1,183,712 | May 21, 2013, 01:44 PM |
| HASTINGS PAUL J | Director | May 15, 2013 | Buy | $29.30 | 853 | 24,993 | 853 | May 17, 2013, 06:02 PM |
| EVNIN LUKE | Director | Apr 12, 2013 | Sale | $29.30 | 3,416 | 100,089 | 1,314,255 | May 08, 2013, 12:55 PM |
| EVNIN LUKE | Director | Apr 12, 2013 | Option Exercise | $2.69 | 37,192 | 100,046 | 1,317,671 | May 08, 2013, 12:55 PM |
| EVNIN LUKE | Director | Apr 24, 2013 | Sale | $30.04 | 6,303 | 189,342 | 1,163,486 | Apr 29, 2013, 04:50 PM |
| EVNIN LUKE | Director | Apr 23, 2013 | Sale | $30.00 | 108,115 | 3,243,450 | 1,169,789 | Apr 29, 2013, 04:50 PM |
| Wicki Andreas | Director | Apr 24, 2013 | Sale | $30.04 | 401 | 12,045 | 2,176,652 | Apr 25, 2013, 07:52 PM |
| Wicki Andreas | Director | Apr 23, 2013 | Sale | $30.00 | 15,646 | 469,380 | 2,177,053 | Apr 25, 2013, 07:52 PM |
| EVNIN LUKE | Director | Apr 15, 2013 | Sale | $30.00 | 2,575 | 77,250 | 1,277,904 | Apr 18, 2013, 05:10 PM |
| EVNIN LUKE | Director | Apr 12, 2013 | Sale | $30.00 | 10,000 | 300,000 | 1,280,479 | Apr 18, 2013, 05:10 PM |
| Wicki Andreas | Director | Apr 15, 2013 | Sale | $30.00 | 6,400 | 192,020 | 2,192,699 | Apr 17, 2013, 06:30 PM |
| PATOU GARY | Chief Medical Officer | Apr 12, 2013 | Option Exercise | $1.61 | 10,000 | 16,100 | 10,000 | Apr 16, 2013, 02:49 PM |
| PATOU GARY | Chief Medical Officer | Apr 12, 2013 | Sale | $30.00 | 10,000 | 300,000 | 0 | Apr 16, 2013, 02:49 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Mar 11, 2013 | Sale | $27.86 | 348,951 | 9,721,775 | 559,453 | Apr 15, 2013, 08:10 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Mar 07, 2013 | Sale | $25.92 | 25,560 | 662,515 | 1,361,762 | Apr 15, 2013, 08:10 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Mar 07, 2013 | Option Exercise | $8.38 | 79,031 | 662,373 | 1,372,169 | Apr 15, 2013, 08:10 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Jan 24, 2013 | Sale | $18.93 | 500,000 | 9,465,000 | 882,562 | Apr 15, 2013, 08:09 PM |
| Wicki Andreas | Director | Apr 12, 2013 | Sale | $30.00 | 34,294 | 1,028,820 | 2,199,099 | Apr 15, 2013, 07:01 PM |
| Wicki Andreas | Director | Apr 11, 2013 | Sale | $30.00 | 600 | 18,000 | 2,233,393 | Apr 15, 2013, 07:01 PM |
| PATOU GARY | Chief Medical Officer | Apr 01, 2013 | Option Exercise | $1.61 | 30,000 | 48,300 | 30,000 | Apr 03, 2013, 12:53 PM |
| PATOU GARY | Chief Medical Officer | Apr 01, 2013 | Sale | $28.15 | 30,000 | 844,591 | 11,300 | Apr 03, 2013, 12:53 PM |
| LONGENECKER JOHN P PHD | Director | Mar 28, 2013 | Option Exercise | $1.61 | 2,000 | 3,220 | 2,000 | Apr 01, 2013, 06:24 PM |
| LONGENECKER JOHN P PHD | Director | Mar 28, 2013 | Sale | $28.49 | 2,000 | 56,980 | 0 | Apr 01, 2013, 06:24 PM |
| STACK DAVID M | President and CEO | Mar 28, 2013 | Option Exercise | $1.61 | 15,000 | 24,150 | 17,573 | Apr 01, 2013, 06:24 PM |
| STACK DAVID M | President and CEO | Mar 28, 2013 | Sale | $28.66 | 15,000 | 429,900 | 2,573 | Apr 01, 2013, 06:24 PM |
| Scibetta James S | Chief Financial Officer | Mar 28, 2013 | Option Exercise | $1.61 | 10,000 | 16,100 | 15,000 | Apr 01, 2013, 06:23 PM |
| Scibetta James S | Chief Financial Officer | Mar 28, 2013 | Sale | $28.49 | 10,000 | 284,900 | 5,000 | Apr 01, 2013, 06:23 PM |
| HBM Healthcare Investments (Cayman) Ltd. | 10% Owner | Mar 22, 2013 | Sale | $27.52 | 113,928 | 3,135,595 | 2,399,534 | Mar 25, 2013, 08:10 PM |
| HBM Healthcare Investments (Cayman) Ltd. | 10% Owner | Mar 21, 2013 | Sale | $27.50 | 11,431 | 314,353 | 2,513,462 | Mar 25, 2013, 08:10 PM |
| HBM Healthcare Investments (Cayman) Ltd. | 10% Owner | Mar 25, 2013 | Sale | $28.28 | 165,541 | 4,680,738 | 2,233,993 | Mar 25, 2013, 08:10 PM |
| Wicki Andreas | Director | Mar 25, 2013 | Sale | $28.28 | 165,541 | 4,680,738 | 2,233,993 | Mar 25, 2013, 07:59 PM |
| Wicki Andreas | Director | Mar 22, 2013 | Sale | $27.52 | 113,928 | 3,135,595 | 2,399,534 | Mar 25, 2013, 07:59 PM |
| Wicki Andreas | Director | Mar 21, 2013 | Sale | $27.50 | 11,431 | 314,353 | 2,513,462 | Mar 25, 2013, 07:59 PM |
| Wicki Andreas | Director | Mar 19, 2013 | Sale | $27.86 | 9,100 | 253,501 | 2,524,893 | Mar 21, 2013, 09:54 PM |
| Wicki Andreas | Director | Mar 18, 2013 | Sale | $28.19 | 400,000 | 11,277,480 | 2,533,993 | Mar 21, 2013, 09:54 PM |
| Wicki Andreas | Director | Mar 11, 2013 | Sale | $27.86 | 500,000 | 13,930,000 | 2,933,993 | Mar 21, 2013, 09:54 PM |
| HBM BIOVENTURES CAYMAN LTD | 10% Owner | Mar 19, 2013 | Sale | $27.86 | 9,100 | 253,501 | 2,524,893 | Mar 21, 2013, 09:52 PM |
| HBM BIOVENTURES CAYMAN LTD | 10% Owner | Mar 18, 2013 | Sale | $28.19 | 400,000 | 11,277,480 | 2,533,993 | Mar 21, 2013, 09:52 PM |
| HBM BIOVENTURES CAYMAN LTD | 10% Owner | Mar 11, 2013 | Sale | $27.86 | 500,000 | 13,930,000 | 2,933,993 | Mar 21, 2013, 09:52 PM |
| Sanderling Venture Partners VI LP | Director | Mar 19, 2013 | Sale | $27.27 | 84,589 | 2,306,831 | 462,422 | Mar 20, 2013, 09:32 PM |
| Sanderling Venture Partners VI LP | Director | Mar 18, 2013 | Sale | $28.69 | 165,411 | 4,745,234 | 530,497 | Mar 20, 2013, 09:32 PM |
| EVNIN LUKE | Director | Mar 18, 2013 | Sale | $28.44 | 500,000 | 14,220,000 | 2,290,479 | Mar 19, 2013, 03:25 PM |
| Riker Lauren Bullaro | Executive Director, Accounting | Mar 14, 2013 | Option Exercise | $10.34 | 10,000 | 103,400 | 12,000 | Mar 18, 2013, 05:24 PM |
| Riker Lauren Bullaro | Executive Director, Accounting | Mar 14, 2013 | Sale | $30.00 | 10,000 | 300,000 | 2,000 | Mar 18, 2013, 05:24 PM |
| Pratt John | General Manager, San Diego | Mar 12, 2013 | Option Exercise | $8.73 | 9,375 | 81,844 | 9,375 | Mar 14, 2013, 05:03 PM |
| Pratt John | General Manager, San Diego | Mar 12, 2013 | Sale | $28.46 | 9,375 | 266,812 | 0 | Mar 14, 2013, 05:03 PM |
| KAILIAN VAUGHN M | Former 10% Owner | Mar 11, 2013 | Sale | $27.86 | 500,000 | 13,930,000 | 2,790,479 | Mar 13, 2013, 12:32 PM |
| MPM BioVentures IV QP LP | Former 10% Owner | Mar 11, 2013 | Sale | $27.86 | 500,000 | 13,930,000 | 2,790,479 | Mar 13, 2013, 12:31 PM |
| EVNIN LUKE | Director | Mar 11, 2013 | Sale | $27.86 | 500,000 | 13,930,000 | 2,790,479 | Mar 13, 2013, 12:29 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Mar 07, 2013 | Sale | $25.92 | 25,560 | 662,515 | 1,361,762 | Mar 11, 2013, 06:59 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Mar 11, 2013 | Sale | $27.86 | 348,951 | 9,721,775 | 559,453 | Mar 11, 2013, 06:59 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Mar 07, 2013 | Option Exercise | $8.38 | 79,031 | 662,373 | 1,372,169 | Mar 11, 2013, 06:59 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Jan 24, 2013 | Sale | $18.93 | 500,000 | 9,465,000 | 882,562 | Jan 25, 2013, 05:04 PM |
| PACE GARY W | Director | Apr 17, 2012 | Buy | $9.75 | 10,000 | 97,500 | 17,692 | Apr 17, 2012, 05:24 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Mar 09, 2012 | Sale | $11.25 | 37,000 | 416,087 | 2,509,400 | Mar 13, 2012, 06:43 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Mar 12, 2012 | Sale | $11.03 | 63,100 | 696,107 | 2,446,700 | Mar 13, 2012, 06:43 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 29, 2012 | Sale | $10.86 | 3,000 | 32,584 | 2,546,100 | Feb 29, 2012, 09:52 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 28, 2012 | Sale | $11.12 | 10,100 | 112,316 | 2,549,200 | Feb 29, 2012, 09:52 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 27, 2012 | Sale | $11.05 | 29,000 | 320,369 | 2,559,500 | Feb 29, 2012, 09:52 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 03, 2012 | Sale | $10.79 | 50,000 | 539,520 | 2,588,700 | Feb 03, 2012, 09:30 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 02, 2012 | Sale | $10.85 | 23,300 | 252,917 | 2,638,400 | Feb 03, 2012, 09:30 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 01, 2012 | Sale | $11.01 | 70,000 | 770,406 | 2,662,200 | Feb 03, 2012, 09:30 PM |
| MIDDLETON FRED A | Director | Nov 21, 2011 | Buy | $6.50 | 10,000 | 65,000 | 10,000 | Nov 23, 2011, 06:09 PM |
| PACE GARY W | Director | Nov 21, 2011 | Buy | $6.50 | 7,692 | 49,998 | 7,692 | Nov 23, 2011, 06:09 PM |
| HBM BIOVENTURES CAYMAN LTD | 10% Owner | Nov 21, 2011 | Buy | $6.50 | 307,692 | 1,999,998 | 3,445,289 | Nov 22, 2011, 06:48 PM |
| Wicki Andreas | Director | Nov 21, 2011 | Buy | $6.50 | 307,692 | 1,999,998 | 3,445,289 | Nov 22, 2011, 06:46 PM |
| MPM BioVentures IV QP LP | 10% Owner | Nov 21, 2011 | Buy | $6.50 | 461,538 | 2,999,997 | 3,290,479 | Nov 22, 2011, 02:04 PM |
| KAILIAN VAUGHN M | 10% Owner | Nov 21, 2011 | Buy | $6.50 | 461,538 | 2,999,997 | 3,290,479 | Nov 22, 2011, 02:00 PM |
| EVNIN LUKE | Director | Nov 21, 2011 | Buy | $6.50 | 461,538 | 2,999,997 | 3,290,479 | Nov 22, 2011, 01:58 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Oct 31, 2011 | Sale | $10.53 | 97,441 | 1,025,635 | 2,732,387 | Nov 02, 2011, 08:04 PM |
| MPM BioVentures IV QP LP | 10% Owner | Feb 08, 2011 | Buy | $7.00 | 535,714 | 3,749,998 | 2,828,941 | Feb 17, 2011, 02:58 PM |
| EVNIN LUKE | Director | Feb 08, 2011 | Buy | $7.00 | 535,714 | 3,749,998 | 2,828,941 | Feb 17, 2011, 02:57 PM |
| KAILIAN VAUGHN M | 10% Owner | Feb 08, 2011 | Buy | $7.00 | 535,714 | 3,749,998 | 2,828,941 | Feb 17, 2011, 02:55 PM |
| Scibetta James S | Chief Financial Officer | Feb 15, 2011 | Buy | $7.04 | 5,000 | 35,200 | 5,000 | Feb 16, 2011, 06:53 PM |
| STACK DAVID M | President and CEO | Feb 10, 2011 | Buy | $6.60 | 5,000 | 33,000 | 23,600 | Feb 11, 2011, 03:29 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Feb 08, 2011 | Buy | $7.00 | 221,478 | 1,550,346 | 184,131 | Feb 10, 2011, 09:55 PM |
| Sanderling Venture Partners VI LP | 10% Owner | Feb 08, 2011 | Buy | $7.00 | 46,379 | 324,653 | 46,379 | Feb 10, 2011, 09:55 PM |
| Wicki Andreas | Director | Feb 08, 2011 | Option Exercise | $13.44 | 1,021,223 | 13,725,237 | 2,601,883 | Feb 10, 2011, 08:36 PM |
| Wicki Andreas | Director | Feb 08, 2011 | Buy | $7.00 | 535,714 | 3,749,998 | 3,137,597 | Feb 10, 2011, 08:36 PM |
| HBM BIOVENTURES CAYMAN LTD | 10% Owner | Feb 08, 2011 | Option Exercise | $13.44 | 1,021,223 | 13,725,237 | 2,601,883 | Feb 10, 2011, 08:35 PM |
| HBM BIOVENTURES CAYMAN LTD | 10% Owner | Feb 08, 2011 | Buy | $7.00 | 535,714 | 3,749,998 | 3,137,597 | Feb 10, 2011, 08:35 PM |
| MIDDLETON FRED A | Director | Feb 08, 2011 | Buy | $7.00 | 267,857 | 1,874,999 | 184,131 | Feb 10, 2011, 08:06 PM |
| GORDON CARL L | Director | Feb 08, 2011 | Option Exercise | $13.44 | 712,567 | 9,576,900 | 2,293,227 | Feb 10, 2011, 06:47 PM |
| GORDON CARL L | Director | Feb 08, 2011 | Buy | $7.00 | 535,714 | 3,749,998 | 2,828,941 | Feb 10, 2011, 06:47 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 08, 2011 | Option Exercise | $13.44 | 6,722 | 90,344 | 2,293,227 | Feb 10, 2011, 06:47 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 08, 2011 | Option Exercise | $13.44 | 705,845 | 9,486,557 | 2,286,505 | Feb 10, 2011, 06:47 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 08, 2011 | Buy | $7.00 | 5,053 | 35,371 | 2,828,941 | Feb 10, 2011, 06:47 PM |
| ORBIMED ADVISORS LLC | 10% Owner | Feb 08, 2011 | Buy | $7.00 | 530,661 | 3,714,627 | 2,826,414 | Feb 10, 2011, 06:47 PM |
| MPM BioVentures IV QP LP | 10% Owner | Feb 08, 2012 | Buy | $7.00 | 535,714 | 3,749,998 | 2,828,941 | Feb 10, 2011, 04:27 PM |
| EVNIN LUKE | Director | Feb 08, 2012 | Buy | $7.00 | 535,714 | 3,749,998 | 2,828,941 | Feb 10, 2011, 04:21 PM |
| KAILIAN VAUGHN M | 10% Owner | Feb 08, 2012 | Buy | $7.00 | 535,714 | 3,749,998 | 2,828,941 | Feb 10, 2011, 04:18 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| LARANJEIRA CHARLES ANTHONY | Chief Technical Officer | 06/14/2022 | 230,100 |
| STACK DAVID M | CEO and Chairman | 06/08/2022 | 827,658 |
| STACK DAVID M | CEO and Chairman | 06/06/2022 | 734,340 |
| WINSTON ROY | Chief Medical Officer | 06/06/2022 | 214,844 |
| WINSTON ROY | Chief Medical Officer | 06/06/2022 | 1,077,135 |
| Williams Kristen Marie | Chief Administrative Officer | 06/06/2022 | 243,593 |
| Williams Kristen Marie | Chief Administrative Officer | 06/07/2022 | 276,662 |
| SLONIN JONATHAN | Chief Clinical Officer | 06/06/2022 | 22,217 |
| Riker Lauren Bullaro | Senior Vice President, Finance | 06/06/2022 | 70,580 |
| Reinhart Charles A. III | Chief Financial Officer | 06/06/2022 | 154,417 |
| REINHARDT MAX | President, Rest of World | 06/07/2022 | 150,846 |
| REINHARDT MAX | President, Rest of World | 06/06/2022 | 172,891 |
| LARANJEIRA CHARLES ANTHONY | Chief Technical Officer | 06/08/2022 | 295,316 |
| LARANJEIRA CHARLES ANTHONY | Chief Technical Officer | 06/06/2022 | 172,645 |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | 06/07/2022 | 154,473 |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | 06/06/2022 | 182,895 |
| McLoughlin Dennis | Chief Customer Officer | 06/06/2022 | 131,340 |
| GAUGLER DARYL | Chief Operating Officer | 06/06/2022 | 67,880 |
| SLONIN JONATHAN | Chief Clinical Officer | 05/23/2022 | 104,740 |
| Froimson Mark | Director | 05/09/2022 | 59,370 |
| STACK DAVID M | CEO and Chairman | 04/28/2022 | 243,225 |
| REINHARDT MAX | President, Rest of World | 04/21/2022 | 531,750 |
| REINHARDT MAX | President, Rest of World | 04/21/2022 | 719,647 |
| REINHARDT MAX | President, Rest of World | 04/18/2022 | 531,750 |
| REINHARDT MAX | President, Rest of World | 04/20/2022 | 531,750 |
| REINHARDT MAX | President, Rest of World | 04/19/2022 | 531,750 |
| REINHARDT MAX | President, Rest of World | 04/20/2022 | 722,438 |
| REINHARDT MAX | President, Rest of World | 04/19/2022 | 673,442 |
| REINHARDT MAX | President, Rest of World | 04/18/2022 | 657,611 |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | 04/06/2022 | 917,407 |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | 04/06/2022 | 1,719,393 |
| STACK DAVID M | CEO and Chairman | 03/31/2022 | 243,225 |
| Williams Kristen Marie | Chief Administrative Officer | 03/21/2022 | 309,462 |
| Williams Kristen Marie | Chief Administrative Officer | 03/21/2022 | 527,075 |
| Riker Lauren Bullaro | Senior Vice President, Finance | 03/10/2022 | 100,533 |
| Riker Lauren Bullaro | Senior Vice President, Finance | 03/10/2022 | 662,331 |
| PACE GARY W | Director | 03/03/2022 | 75,670 |
| LONGENECKER JOHN P PHD | Director | 03/03/2022 | 75,670 |
| LONGENECKER JOHN P PHD | Director | 03/03/2022 | 502,145 |
| PACE GARY W | Director | 03/01/2022 | 14,976 |
| PACE GARY W | Director | 02/28/2022 | 315,624 |
| PACE GARY W | Director | 03/01/2022 | 92,072 |
| PACE GARY W | Director | 02/28/2022 | 1,914,078 |
| Williams Kristen Marie | Chief Administrative Officer | 02/25/2022 | 78,617 |
| Williams Kristen Marie | Chief Administrative Officer | 02/16/2022 | 383 |
| Williams Kristen Marie | Chief Administrative Officer | 02/16/2022 | 650 |
| Williams Kristen Marie | Chief Administrative Officer | 02/25/2022 | 137,390 |
| Williams Kristen Marie | Chief Administrative Officer | 02/04/2022 | 38,350 |
| Williams Kristen Marie | Chief Administrative Officer | 02/04/2022 | 65,180 |
| STACK DAVID M | CEO and Chairman | 01/25/2022 | 147,773 |
| Williams Kristen Marie | Chief Administrative Officer | 01/21/2022 | 7,670 |
| Williams Kristen Marie | Chief Administrative Officer | 01/21/2022 | 13,082 |
| Williams Kristen Marie | Chief Administrative Officer | 01/18/2022 | 1,061,943 |
| Williams Kristen Marie | Chief Administrative Officer | 01/19/2022 | 84,332 |
| Williams Kristen Marie | Chief Administrative Officer | 01/18/2022 | 1,529,586 |
| Williams Kristen Marie | Chief Administrative Officer | 01/19/2022 | 144,056 |
| Riker Lauren Bullaro | Senior Vice President, Finance | 01/18/2022 | 27,025 |
| Riker Lauren Bullaro | Senior Vice President, Finance | 01/18/2022 | 162,430 |
| MOLLOY ANTHONY | Chief Lgl & Compliance Officer | 01/18/2022 | 14,235 |
| STACK DAVID M | CEO and Chairman | 01/11/2022 | 162,150 |
| LARANJEIRA CHARLES ANTHONY | Chief Technical Officer | 11/22/2021 | 330,750 |
| STACK DAVID M | CEO and Chairman | 11/16/2021 | 162,150 |
| WINSTON ROY | Chief Medical Officer | 11/04/2021 | 481,500 |
| Riker Lauren Bullaro | Vice President, Finance | 07/28/2021 | 26,052 |
| Riker Lauren Bullaro | Vice President, Finance | 07/29/2021 | 973 |
| Riker Lauren Bullaro | Vice President, Finance | 07/28/2021 | 146,648 |
| Riker Lauren Bullaro | Vice President, Finance | 07/29/2021 | 5,473 |
| REINHARDT MAX | President, Rest of World | 07/02/2021 | 25,159 |
| REINHARDT MAX | President, Rest of World | 06/04/2021 | 74,587 |
| REINHARDT MAX | President, Rest of World | 06/07/2021 | 137,819 |
| McLoughlin Dennis | Chief Customer Officer | 06/04/2021 | 115,665 |
| HASTINGS PAUL J | Director | 06/04/2021 | 39,180 |
| STACK DAVID M | CEO and Chairman | 05/12/2021 | 229,713 |
| STACK DAVID M | CEO and Chairman | 05/11/2021 | 229,713 |
| STACK DAVID M | CEO and Chairman | 05/12/2021 | 1,316,471 |
| STACK DAVID M | CEO and Chairman | 05/11/2021 | 1,294,827 |
| Williams Kristen Marie | Chief Administrative Officer | 04/13/2021 | 878,943 |
| Williams Kristen Marie | Chief Administrative Officer | 04/13/2021 | 1,461,069 |
| WINSTON ROY | Chief Clinical Officer | 03/31/2021 | 472,656 |
| WINSTON ROY | Chief Clinical Officer | 03/31/2021 | 1,569,195 |
| Riker Lauren Bullaro | Vice President, Finance | 03/17/2021 | 21,620 |
| Riker Lauren Bullaro | Vice President, Finance | 03/15/2021 | 16,431 |
| Riker Lauren Bullaro | Vice President, Finance | 03/15/2021 | 111,386 |
| Riker Lauren Bullaro | Vice President, Finance | 03/17/2021 | 140,020 |
| Froimson Mark | Director | 03/15/2021 | 53,039 |
| Wicki Andreas | Director | 03/12/2021 | 4,294,917 |
| Wicki Andreas | Director | 03/15/2021 | 781,082 |
| Wicki Andreas | Director | 03/11/2021 | 4,403,730 |
| Wicki Andreas | Director | 03/10/2021 | 5,489,734 |
| Wicki Andreas | Director | 03/09/2021 | 2,491,213 |
| HASTINGS PAUL J | Director | 03/05/2021 | 41,940 |
| HASTINGS PAUL J | Director | 03/05/2021 | 197,640 |
| LONGENECKER JOHN P PHD | Director | 03/01/2021 | 69,900 |
| LONGENECKER JOHN P PHD | Director | 03/01/2021 | 361,300 |
| STACK DAVID M | CEO and Chairman | 02/02/2021 | 229,713 |
| STACK DAVID M | CEO and Chairman | 02/03/2021 | 229,713 |
| STACK DAVID M | CEO and Chairman | 02/03/2021 | 1,513,259 |
| STACK DAVID M | CEO and Chairman | 02/02/2021 | 1,474,874 |
| REINHARDT MAX | President | 01/06/2021 | 6,689 |
| Brege Laura | Director | 11/16/2020 | 167,760 |
| Brege Laura | Director | 11/16/2020 | 791,400 |
| Riker Lauren Bullaro | Vice President, Finance | 11/13/2020 | 32,430 |
| Riker Lauren Bullaro | Vice President, Finance | 11/13/2020 | 191,430 |
| WINSTON ROY | Chief Clinical Officer | 11/13/2020 | 310,000 |
| REINHARDT MAX | President | 11/13/2020 | 1,063,500 |
| REINHARDT MAX | President | 11/13/2020 | 1,584,390 |
| STACK DAVID M | CEO and Chairman | 10/15/2020 | 324,300 |
| STACK DAVID M | CEO and Chairman | 10/14/2020 | 324,300 |
| STACK DAVID M | CEO and Chairman | 10/16/2020 | 324,300 |
| STACK DAVID M | CEO and Chairman | 10/15/2020 | 1,650,000 |
| STACK DAVID M | CEO and Chairman | 10/14/2020 | 1,665,900 |
| STACK DAVID M | CEO and Chairman | 10/16/2020 | 1,666,800 |
| PACE GARY W | Director | 09/25/2020 | 1,166,900 |
| REINHARDT MAX | President | 09/17/2020 | 1,063,500 |
| REINHARDT MAX | President | 09/17/2020 | 1,520,318 |
| Williams Kristen Marie | Chief Administrative Officer | 09/16/2020 | 1,091,560 |
| Williams Kristen Marie | Chief Administrative Officer | 09/15/2020 | 1,091,560 |
| Williams Kristen Marie | Chief Administrative Officer | 09/17/2020 | 1,092,268 |
| Williams Kristen Marie | Chief Administrative Officer | 09/15/2020 | 1,654,058 |
| Williams Kristen Marie | Chief Administrative Officer | 09/17/2020 | 1,667,290 |
| Williams Kristen Marie | Chief Administrative Officer | 09/16/2020 | 1,675,150 |
| Riker Lauren Bullaro | Vice President, Finance | 09/16/2020 | 32,430 |
| Riker Lauren Bullaro | Vice President, Finance | 09/16/2020 | 181,020 |
| Wicki Andreas | Director | 09/09/2020 | 137,436 |
| STACK DAVID M | CEO and Chairman | 08/17/2020 | 928,619 |
| Wicki Andreas | Director | 08/13/2020 | 2,145,549 |
| Wicki Andreas | Director | 08/12/2020 | 6,903,070 |
| Wicki Andreas | Director | 08/11/2020 | 6,546,747 |
| Riker Lauren Bullaro | Vice President, Finance | 08/11/2020 | 84,581 |
| Riker Lauren Bullaro | Vice President, Finance | 08/11/2020 | 494,890 |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | 08/03/2020 | 110,250 |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | 08/03/2020 | 131,700 |
| STACK DAVID M | CEO and Chairman | 07/15/2020 | 682,560 |
| Riker Lauren Bullaro | Vice President, Finance | 06/29/2020 | 62,040 |
| Riker Lauren Bullaro | Vice President, Finance | 06/29/2020 | 296,800 |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | 06/29/2020 | 2,366,587 |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | 06/29/2020 | 3,021,314 |
| Williams Kristen Marie | Chief Administrative Officer | 06/05/2020 | 286,993 |
| Williams Kristen Marie | Chief Administrative Officer | 06/04/2020 | 111,287 |
| STACK DAVID M | CEO and Chairman | 06/04/2020 | 663,182 |
| STACK DAVID M | CEO and Chairman | 06/08/2020 | 823,403 |
| Riker Lauren Bullaro | Vice President, Finance | 06/05/2020 | 84,744 |
| Riker Lauren Bullaro | Vice President, Finance | 06/04/2020 | 40,725 |
| Reinhart Charles A. III | Chief Financial Officer | 06/04/2020 | 68,987 |
| McLoughlin Dennis | Chief Commercial Officer | 06/04/2020 | 67,041 |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | 06/04/2020 | 39,984 |
| HASTINGS PAUL J | Director | 06/04/2020 | 96,106 |
| Brege Laura | Director | 06/05/2020 | 102,270 |
| Riker Lauren Bullaro | Vice President, Finance | 05/19/2020 | 20,680 |
| Riker Lauren Bullaro | Vice President, Finance | 05/21/2020 | 20,680 |
| Riker Lauren Bullaro | Vice President, Finance | 05/19/2020 | 85,620 |
| Riker Lauren Bullaro | Vice President, Finance | 05/21/2020 | 90,520 |
| PACE GARY W | Director | 03/12/2020 | 96,845 |
| LONGENECKER JOHN P PHD | Director | 03/12/2020 | 6,015 |
| WINSTON ROY | Chief Clinical Officer | 03/11/2020 | 91,250 |
| STACK DAVID M | CEO and Chairman | 02/21/2020 | 121,189 |
| Riker Lauren Bullaro | Vice President, Finance | 02/10/2020 | 32,430 |
| Riker Lauren Bullaro | Vice President, Finance | 02/10/2020 | 146,430 |
| Riker Lauren Bullaro | Vice President, Finance | 02/06/2020 | 8,972 |
| Riker Lauren Bullaro | Vice President, Finance | 02/07/2020 | 1,838 |
| Riker Lauren Bullaro | Vice President, Finance | 02/07/2020 | 7,958 |
| Riker Lauren Bullaro | Vice President, Finance | 02/06/2020 | 38,852 |
| STACK DAVID M | CEO and Chairman | 01/15/2020 | 270,250 |
| STACK DAVID M | CEO and Chairman | 01/15/2020 | 1,066,968 |
| STACK DAVID M | CEO and Chairman | 12/26/2019 | 71,000 |
| Riker Lauren Bullaro | Vice President, Finance | 12/23/2019 | 10,810 |
| Riker Lauren Bullaro | Vice President, Finance | 12/23/2019 | 45,920 |
| McLoughlin Dennis | Chief Commercial Officer | 12/16/2019 | 168,108 |
| LONGENECKER JOHN P PHD | Director | 12/02/2019 | 6,440 |
| LONGENECKER JOHN P PHD | Director | 12/02/2019 | 59,972 |
| Riker Lauren Bullaro | Vice President, Finance | 11/20/2019 | 10,810 |
| Riker Lauren Bullaro | Vice President, Finance | 11/20/2019 | 51,909 |
| STACK DAVID M | CEO and Chairman | 11/15/2019 | 270,250 |
| STACK DAVID M | CEO and Chairman | 11/15/2019 | 1,070,250 |
| STACK DAVID M | CEO and Chairman | 11/15/2019 | 1,926,450 |
| Riker Lauren Bullaro | Vice President, Finance | 11/11/2019 | 51,785 |
| Riker Lauren Bullaro | Vice President, Finance | 11/11/2019 | 217,950 |
| Scranton Richard | Chief Scientific Officer | 11/08/2019 | 279,393 |
| Scranton Richard | Chief Scientific Officer | 11/08/2019 | 875,160 |
| STACK DAVID M | CEO and Chairman | 10/02/2019 | 66,170 |
| STACK DAVID M | CEO and Chairman | 09/18/2019 | 47,760 |
| STACK DAVID M | CEO and Chairman | 08/15/2019 | 138,898 |
| STACK DAVID M | CEO and Chairman | 08/15/2019 | 503,092 |
| Williams Kristen Marie | Chief Administrative Officer | 08/14/2019 | 246,891 |
| STACK DAVID M | CEO and Chairman | 07/08/2019 | 562,377 |
| STACK DAVID M | CEO and Chairman | 06/11/2019 | 73,560 |
| Riker Lauren Bullaro | Vice President, Finance | 06/10/2019 | 94,139 |
| WINSTON ROY | Chief Clinical Officer | 06/04/2019 | 30,981 |
| Williams Kristen Marie | CAO and General Counsel | 06/04/2019 | 108,519 |
| STACK DAVID M | CEO and Chairman | 06/04/2019 | 531,440 |
| Scranton Richard | Chief Scientific Officer | 06/05/2019 | 178,959 |
| Scranton Richard | Chief Scientific Officer | 06/04/2019 | 210,662 |
| Riker Lauren Bullaro | Vice President, Finance | 06/04/2019 | 41,494 |
| Reinhart Charles A. III | Chief Financial Officer | 06/04/2019 | 47,458 |
| McLoughlin Dennis | Chief Commercial Officer | 06/04/2019 | 47,158 |
| LARANJEIRA CHARLES ANTHONY | SVP, Technical Operations | 06/04/2019 | 18,451 |
| HASTINGS PAUL J | Director | 06/04/2019 | 33,360 |
| Scranton Richard | Chief Scientific Officer | 06/03/2019 | 166,790 |
| Scranton Richard | Chief Scientific Officer | 06/03/2019 | 670,187 |
| Kronenfeld Mark A. | Director | 03/06/2019 | 66,244 |
| STACK DAVID M | CEO and Chairman | 12/18/2018 | 42,600 |
| Wicki Andreas | Director | 12/13/2018 | 402,692 |
| Wicki Andreas | Director | 12/12/2018 | 277,803 |
| Wicki Andreas | Director | 11/19/2018 | 46,605 |
| PACE GARY W | Director | 11/19/2018 | 207,810 |
| Wicki Andreas | Director | 11/16/2018 | 1,198,775 |
| Wicki Andreas | Director | 11/15/2018 | 896,145 |
| Wicki Andreas | Director | 11/15/2018 | 1,242,666 |
| STACK DAVID M | CEO and Chairman | 11/15/2018 | 710,801 |
| Wicki Andreas | Director | 11/12/2018 | 272,980 |
| Wicki Andreas | Director | 11/09/2018 | 45,508 |
| Wicki Andreas | Director | 11/08/2018 | 2,931,583 |
| PACE GARY W | Director | 11/07/2018 | 205,160 |
| Riker Lauren Bullaro | Vice President, Finance | 11/02/2018 | 10,340 |
| Riker Lauren Bullaro | Vice President, Finance | 11/02/2018 | 54,350 |
| STACK DAVID M | CEO and Chairman | 10/11/2018 | 130,650 |
| Riker Lauren Bullaro | Vice President, Finance | 09/24/2018 | 10,340 |
| Riker Lauren Bullaro | Vice President, Finance | 09/24/2018 | 50,700 |
| Kronenfeld Mark A. | Director | 08/28/2018 | 44,611 |
| Riker Lauren Bullaro | Vice President, Finance | 08/22/2018 | 74,148 |
| STACK DAVID M | CEO and Chairman | 08/15/2018 | 149,079 |
| STACK DAVID M | CEO and Chairman | 08/15/2018 | 1,564,432 |
| Williams Kristen Marie | CAO and General Counsel | 08/14/2018 | 224,522 |
| STACK DAVID M | CEO and Chairman | 06/07/2018 | 360,984 |
| STACK DAVID M | CEO and Chairman | 06/06/2018 | 306,780 |
| Williams Kristen Marie | CAO and General Counsel | 06/04/2018 | 67,361 |
| Weiland Robert J. | Chief Commercial Officer | 06/04/2018 | 12,316 |
| Scranton Richard | Chief Scientific Officer | 06/04/2018 | 45,138 |
| Riker Lauren Bullaro | Vice President, Finance | 06/04/2018 | 26,449 |
| Reinhart Charles A. III | Chief Financial Officer | 06/04/2018 | 23,378 |
| HASTINGS PAUL J | Director | 06/04/2018 | 26,137 |
| STACK DAVID M | CEO and Chairman | 05/15/2018 | 190,450 |
| STACK DAVID M | CEO and Chairman | 05/15/2018 | 844,781 |
| STACK DAVID M | CEO and Chairman | 01/10/2018 | 46,505 |
| STACK DAVID M | CEO and Chairman | 01/10/2018 | 1,160,975 |
| Riker Lauren Bullaro | Vice President, Finance | 12/15/2017 | 14,858 |
| Williams Kristen Marie | CAO and General Counsel | 11/17/2017 | 199,332 |
| Williams Kristen Marie | CAO and General Counsel | 11/16/2017 | 54,368 |
| Williams Kristen Marie | CAO and General Counsel | 11/17/2017 | 314,280 |
| Williams Kristen Marie | CAO and General Counsel | 11/16/2017 | 85,741 |
| Jones James B | SVP & Chief Medical Officer | 11/20/2017 | 34,942 |
| STACK DAVID M | CEO and Chairman | 11/15/2017 | 46,505 |
| STACK DAVID M | CEO and Chairman | 11/15/2017 | 2,257,708 |
| Kronenfeld Mark A. | Director | 11/10/2017 | 41,603 |
| HASTINGS PAUL J | Director | 08/22/2017 | 37,741 |
| Williams Kristen Marie | CAO and General Counsel | 08/15/2017 | 127,192 |
| STACK DAVID M | CEO and Chairman | 08/15/2017 | 46,505 |
| STACK DAVID M | CEO and Chairman | 08/15/2017 | 1,050,547 |
| Froimson Mark | Director | 08/08/2017 | 3,713 |
| STACK DAVID M | CEO and Chairman | 07/24/2017 | 24,150 |
| STACK DAVID M | CEO and Chairman | 06/23/2017 | 24,150 |
| Riker Lauren Bullaro | Vice President, Finance | 06/07/2017 | 49,650 |
| Williams Kristen Marie | CAO and General Counsel | 06/05/2017 | 81,314 |
| STACK DAVID M | CEO and Chairman | 06/05/2017 | 186,757 |
| Scibetta James S | President | 06/05/2017 | 85,169 |
| Riker Lauren Bullaro | Vice President, Finance | 06/05/2017 | 26,036 |
| Jones James B | SVP & Chief Medical Officer | 06/05/2017 | 33,227 |
| Braunstein Scott | SVP, Strategy & Corp. Dev. | 06/05/2017 | 33,271 |
| Williams Kristen Marie | CAO and General Counsel | 05/15/2017 | 220,856 |
| Williams Kristen Marie | CAO and General Counsel | 05/15/2017 | 1,070,145 |
| Scibetta James S | President | 05/15/2017 | 109,800 |
| Scibetta James S | President | 05/15/2017 | 1,024,000 |
| Scibetta James S | President | 01/17/2017 | 100,593 |
| Scibetta James S | President | 01/17/2017 | 770,6 |