ChemoCentryx Inc. (CCXI) NASDAQ
$51.99 - (-)
Market Cap: -
As of 10/19/22 12:00 AM EDT. Market closed.
ChemoCentryx Inc. (CCXI)
NASDAQ
$51.99
- (-)
Market Cap: -
As of 10/19/22 12:00 AM EDT. Market closed.
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ChemoCentryx is a biopharmaceutical company developing new medications for inflammatory and autoimmune diseases and cancer. ChemoCentryx targets the chemokine and chemoattractant systems to discover, develop and commercialize orally-administered therapies. ChemoCentryx's lead drug candidate, avacopan (CCX168), successfully completed a pivotal Phase III trial in ANCA-associated vasculitis and a ... read more
COMPANY PROFILE
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
Thomas Schall
Full Time Employees
133
CEO Compensation (Base)
$616,890
CEO Compensation (Total)
$3.86M
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
Thomas Schall
Full Time Employees
133
CEO Compensation (Base)
$616,890
CEO Compensation (Total)
$3.86M
Address
850 Maude Ave, California, Mountain View, 94043-4022.
PRICE CHART FOR CHEMOCENTRYX INC
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
-
Previous Close
$51.99
Days Range
$51.98 - $52
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
71,355,872
Open
-
Previous Close
$51.99
Days Range
$51.98 - $52
52 week range
- - -
Volume
0
Avg. Volume (30 days)
0
Market Cap
-
Dividend Yield
-
P/E
-
Shares Outstanding
71,355,872
FINANCIAL STATEMENTS FOR CHEMOCENTRYX INC
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INSIDER TRANSACTIONS FOR CHEMOCENTRYX INC
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| KANAYA SUSAN M | EVP, CFO and Sec. | Aug 16, 2022 | Option Exercise | $10.86 | 19,898 | 216,092 | 111,215 | Aug 18, 2022, 04:48 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Aug 16, 2022 | Sale | $50.95 | 19,898 | 1,013,793 | 91,317 | Aug 18, 2022, 04:48 PM |
| Schall Thomas J. | President and CEO | Aug 04, 2022 | Option Exercise | $14.28 | 130,000 | 1,856,400 | 2,523,352 | Aug 08, 2022, 07:41 PM |
| Schall Thomas J. | President and CEO | Aug 04, 2022 | Sale | $50.24 | 130,000 | 6,531,733 | 2,393,352 | Aug 08, 2022, 07:41 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Aug 04, 2022 | Option Exercise | $6.50 | 46,298 | 300,805 | 137,615 | Aug 08, 2022, 07:33 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Aug 04, 2022 | Sale | $50.17 | 46,298 | 2,322,715 | 91,317 | Aug 08, 2022, 07:33 PM |
| Tyree James L | Director | Aug 04, 2022 | Sale | $50.22 | 10,000 | 502,200 | 9,138 | Aug 08, 2022, 07:27 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Aug 04, 2022 | Sale | $50.22 | 7,564 | 379,864 | 87,658 | Aug 08, 2022, 07:21 PM |
| Tyree James L | Director | Jun 09, 2022 | Sale | $25.66 | 3,863 | 99,129 | 19,197 | Jun 13, 2022, 06:28 PM |
| Parker Geoffrey M. | Director | May 02, 2022 | Option Exercise | $14.42 | 12,500 | 180,250 | 124,413 | May 03, 2022, 10:29 AM |
| FECZKO JOSEPH M | Director | Jan 21, 2022 | Option Exercise | $15.41 | 37,500 | 577,750 | 148,127 | Jan 25, 2022, 08:03 PM |
| Schall Thomas J. | President and CEO | Jan 01, 2022 | Option Exercise | $36.41 | 45,698 | 1,663,864 | 2,393,352 | Jan 04, 2022, 09:42 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 01, 2022 | Option Exercise | $36.41 | 16,847 | 613,399 | 132,717 | Jan 04, 2022, 09:38 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 01, 2022 | Option Exercise | $36.41 | 11,538 | 420,099 | 95,222 | Jan 04, 2022, 09:35 PM |
| Tyree James L | Director | Dec 17, 2021 | Option Exercise | $13.22 | 37,500 | 495,750 | 52,775 | Dec 21, 2021, 06:33 PM |
| Tyree James L | Director | Dec 17, 2021 | Sale | $35.02 | 37,500 | 1,313,165 | 49,975 | Dec 21, 2021, 06:33 PM |
| Schall Thomas J. | President and CEO | Dec 01, 2021 | Option Exercise | $10.88 | 45,936 | 499,994 | 2,354,816 | Dec 03, 2021, 07:39 PM |
| Vifor (International) Ltd | 10% Owner | Oct 12, 2021 | Sale | $39.43 | 4,000,000 | 157,720,001 | 5,194,085 | Oct 13, 2021, 07:05 PM |
| Tyree James L | Director | May 21, 2021 | Sale | $9.76 | 2,454 | 23,956 | 15,275 | May 24, 2021, 08:19 PM |
| Parker Geoffrey M. | Director | Mar 05, 2021 | Sale | $56.38 | 30,000 | 1,691,468 | 26,020 | Mar 08, 2021, 08:28 PM |
| Parker Geoffrey M. | Director | Mar 04, 2021 | Sale | $60.20 | 1,910 | 114,980 | 42,690 | Mar 08, 2021, 08:28 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 01, 2021 | Option Exercise | $10.24 | 33,092 | 338,972 | 118,918 | Mar 03, 2021, 08:39 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 01, 2021 | Sale | $68.43 | 33,092 | 2,264,443 | 111,865 | Mar 03, 2021, 08:39 PM |
| Edwards Thomas A. | Director | Mar 02, 2021 | Sale | $70.06 | 1,100 | 77,063 | 120,457 | Mar 03, 2021, 08:33 PM |
| Kwan Pui San | Principal Acctg Officer | Mar 01, 2021 | Option Exercise | $10.46 | 3,347 | 35,012 | 6,579 | Mar 01, 2021, 08:54 PM |
| Kwan Pui San | Principal Acctg Officer | Mar 01, 2021 | Sale | $68.52 | 3,347 | 229,335 | 5,049 | Mar 01, 2021, 08:54 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 09, 2021 | Option Exercise | $11.02 | 700 | 7,714 | 86,526 | Feb 11, 2021, 08:02 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 09, 2021 | Sale | $69.66 | 700 | 48,765 | 85,826 | Feb 11, 2021, 08:02 PM |
| Edwards Thomas A. | Director | Feb 09, 2021 | Sale | $70.04 | 400 | 28,014 | 120,957 | Feb 11, 2021, 07:52 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 08, 2021 | Option Exercise | $11.02 | 7,420 | 81,768 | 93,246 | Feb 08, 2021, 08:31 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 05, 2021 | Option Exercise | $11.02 | 805 | 8,871 | 86,631 | Feb 08, 2021, 08:31 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 04, 2021 | Option Exercise | $11.02 | 1,400 | 15,428 | 87,226 | Feb 08, 2021, 08:31 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 08, 2021 | Sale | $67.30 | 7,420 | 499,351 | 86,026 | Feb 08, 2021, 08:31 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 05, 2021 | Sale | $67.07 | 805 | 53,994 | 85,826 | Feb 08, 2021, 08:31 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 04, 2021 | Sale | $67.14 | 1,400 | 93,995 | 85,826 | Feb 08, 2021, 08:31 PM |
| Kwan Pui San | Principal Acctg Officer | Feb 04, 2021 | Option Exercise | $10.46 | 3,347 | 35,012 | 6,579 | Feb 08, 2021, 08:25 PM |
| Kwan Pui San | Principal Acctg Officer | Feb 04, 2021 | Sale | $65.00 | 3,347 | 217,555 | 3,232 | Feb 08, 2021, 08:25 PM |
| Edwards Thomas A. | Director | Feb 02, 2021 | Sale | $60.94 | 20,000 | 1,218,844 | 129,340 | Feb 04, 2021, 07:58 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 25, 2021 | Option Exercise | $11.02 | 1,375 | 15,153 | 87,201 | Jan 27, 2021, 08:22 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 25, 2021 | Sale | $67.03 | 1,375 | 92,172 | 85,826 | Jan 27, 2021, 08:22 PM |
| Kwan Pui San | Principal Acctg Officer | Jan 25, 2021 | Option Exercise | $9.70 | 4,184 | 40,564 | 7,416 | Jan 27, 2021, 07:25 PM |
| Kwan Pui San | Principal Acctg Officer | Jan 25, 2021 | Sale | $65.00 | 4,184 | 271,960 | 3,232 | Jan 27, 2021, 07:25 PM |
| Schall Thomas J. | President and CEO | Jan 01, 2021 | Option Exercise | $61.92 | 47,576 | 2,945,906 | 2,308,880 | Jan 07, 2021, 08:40 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 01, 2021 | Option Exercise | $61.92 | 16,498 | 1,021,556 | 118,765 | Jan 07, 2021, 08:32 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 01, 2021 | Option Exercise | $61.92 | 11,521 | 713,380 | 85,826 | Jan 07, 2021, 08:26 PM |
| Edwards Thomas A. | Director | Dec 28, 2020 | Sale | $61.50 | 10,782 | 663,093 | 141,357 | Dec 29, 2020, 06:58 PM |
| Edwards Thomas A. | Director | Dec 24, 2020 | Sale | $61.18 | 14,218 | 869,904 | 152,139 | Dec 29, 2020, 06:58 PM |
| Schall Thomas J. | President and CEO | Dec 14, 2020 | Option Exercise | $14.31 | 11,153 | 159,599 | 2,279,710 | Dec 16, 2020, 07:51 PM |
| Schall Thomas J. | President and CEO | Dec 15, 2020 | Option Exercise | $14.31 | 17,619 | 252,128 | 2,286,176 | Dec 16, 2020, 07:51 PM |
| Schall Thomas J. | President and CEO | Dec 14, 2020 | Sale | $65.03 | 11,153 | 725,246 | 2,268,557 | Dec 16, 2020, 07:51 PM |
| Schall Thomas J. | President and CEO | Dec 15, 2020 | Sale | $65.01 | 17,619 | 1,145,450 | 2,268,557 | Dec 16, 2020, 07:51 PM |
| Kwan Pui San | Principal Acctg Officer | Dec 15, 2020 | Option Exercise | $10.07 | 42,593 | 428,943 | 45,825 | Dec 16, 2020, 07:46 PM |
| Kwan Pui San | Principal Acctg Officer | Dec 14, 2020 | Option Exercise | $7.05 | 8,957 | 63,158 | 12,189 | Dec 16, 2020, 07:46 PM |
| Kwan Pui San | Principal Acctg Officer | Dec 15, 2020 | Sale | $65.06 | 42,593 | 2,771,237 | 3,232 | Dec 16, 2020, 07:46 PM |
| Kwan Pui San | Principal Acctg Officer | Dec 14, 2020 | Sale | $65.02 | 8,957 | 582,398 | 3,232 | Dec 16, 2020, 07:46 PM |
| Vifor (International) Ltd | 10% Owner | Jul 31, 2020 | Sale | $52.39 | 40,402 | 2,116,824 | 9,273,736 | Aug 03, 2020, 07:10 PM |
| Vifor (International) Ltd | 10% Owner | Jul 30, 2020 | Sale | $54.60 | 48,081 | 2,625,330 | 9,330,670 | Aug 03, 2020, 07:10 PM |
| Vifor (International) Ltd | 10% Owner | Aug 03, 2020 | Sale | $53.93 | 49,258 | 2,656,655 | 9,242,558 | Aug 03, 2020, 07:10 PM |
| Vifor (International) Ltd | 10% Owner | Jul 29, 2020 | Sale | $52.58 | 88,012 | 4,627,479 | 9,410,510 | Jul 29, 2020, 07:55 PM |
| Vifor (International) Ltd | 10% Owner | Jul 28, 2020 | Sale | $53.51 | 40,160 | 2,149,117 | 9,426,628 | Jul 29, 2020, 07:55 PM |
| Vifor (International) Ltd | 10% Owner | Jul 27, 2020 | Sale | $53.32 | 34,236 | 1,825,476 | 9,470,788 | Jul 29, 2020, 07:55 PM |
| Vifor (International) Ltd | 10% Owner | Jul 23, 2020 | Sale | $54.15 | 34,555 | 1,871,297 | 9,532,691 | Jul 24, 2020, 07:53 PM |
| Vifor (International) Ltd | 10% Owner | Jul 22, 2020 | Sale | $55.58 | 72,469 | 4,027,868 | 9,578,280 | Jul 24, 2020, 07:53 PM |
| Vifor (International) Ltd | 10% Owner | Jul 24, 2020 | Sale | $52.54 | 26,050 | 1,368,737 | 9,504,595 | Jul 24, 2020, 07:53 PM |
| Vifor (International) Ltd | 10% Owner | Jul 21, 2020 | Sale | $55.50 | 87,529 | 4,857,632 | 9,633,571 | Jul 21, 2020, 06:32 PM |
| Vifor (International) Ltd | 10% Owner | Jul 20, 2020 | Sale | $56.03 | 54,598 | 3,059,053 | 9,752,433 | Jul 21, 2020, 06:32 PM |
| Vifor (International) Ltd | 10% Owner | Jul 17, 2020 | Sale | $55.86 | 47,890 | 2,675,105 | 9,791,748 | Jul 21, 2020, 06:32 PM |
| Vifor (International) Ltd | 10% Owner | Jul 15, 2020 | Sale | $59.22 | 86,298 | 5,110,971 | 9,954,810 | Jul 16, 2020, 08:00 PM |
| Vifor (International) Ltd | 10% Owner | Jul 14, 2020 | Sale | $58.08 | 100,000 | 5,808,318 | 10,064,096 | Jul 16, 2020, 08:00 PM |
| Vifor (International) Ltd | 10% Owner | Jul 16, 2020 | Sale | $56.96 | 73,500 | 4,186,741 | 9,863,485 | Jul 16, 2020, 08:00 PM |
| Vifor (International) Ltd | 10% Owner | Jul 13, 2020 | Sale | $58.15 | 100,000 | 5,815,027 | 10,135,831 | Jul 13, 2020, 07:18 PM |
| Vifor (International) Ltd | 10% Owner | Jul 10, 2020 | Sale | $59.92 | 45,844 | 2,747,172 | 10,213,744 | Jul 13, 2020, 07:18 PM |
| Vifor (International) Ltd | 10% Owner | Jul 09, 2020 | Sale | $59.91 | 100,000 | 5,990,521 | 10,269,012 | Jul 13, 2020, 07:18 PM |
| Vifor (International) Ltd | 10% Owner | Jul 06, 2020 | Sale | $58.44 | 86,690 | 5,066,120 | 10,541,219 | Jul 08, 2020, 08:39 PM |
| Vifor (International) Ltd | 10% Owner | Jul 08, 2020 | Sale | $59.95 | 100,000 | 5,994,745 | 10,404,940 | Jul 08, 2020, 08:39 PM |
| Vifor (International) Ltd | 10% Owner | Jul 07, 2020 | Sale | $59.21 | 79,387 | 4,700,838 | 10,499,904 | Jul 08, 2020, 08:39 PM |
| Vifor (International) Ltd | 10% Owner | Jul 02, 2020 | Sale | $57.47 | 87,781 | 5,044,434 | 10,661,449 | Jul 07, 2020, 06:57 PM |
| Schall Thomas J. | President and CEO | Jun 15, 2020 | Option Exercise | $14.31 | 2,000 | 28,620 | 2,270,557 | Jun 16, 2020, 08:20 PM |
| Schall Thomas J. | President and CEO | Jun 12, 2020 | Option Exercise | $14.31 | 88,753 | 1,270,055 | 2,357,310 | Jun 16, 2020, 08:20 PM |
| Schall Thomas J. | President and CEO | Jun 15, 2020 | Sale | $65.04 | 2,000 | 130,090 | 2,268,557 | Jun 16, 2020, 08:20 PM |
| Schall Thomas J. | President and CEO | Jun 12, 2020 | Sale | $65.08 | 88,753 | 5,775,877 | 2,268,557 | Jun 16, 2020, 08:20 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 12, 2020 | Option Exercise | $9.32 | 50,000 | 466,100 | 141,317 | Jun 16, 2020, 08:08 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 12, 2020 | Sale | $64.58 | 50,000 | 3,229,035 | 91,317 | Jun 16, 2020, 08:08 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 12, 2020 | Option Exercise | $10.86 | 33,541 | 364,255 | 109,788 | Jun 16, 2020, 08:02 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 12, 2020 | Sale | $65.10 | 33,541 | 2,183,519 | 76,247 | Jun 16, 2020, 08:02 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 03, 2020 | Option Exercise | $5.31 | 10,750 | 57,059 | 104,930 | Jun 05, 2020, 07:11 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 22, 2020 | Option Exercise | $6.62 | 40,867 | 270,540 | 117,114 | May 26, 2020, 09:04 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 21, 2020 | Option Exercise | $6.62 | 2,800 | 18,536 | 79,047 | May 26, 2020, 09:04 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 26, 2020 | Option Exercise | $6.62 | 19,612 | 129,831 | 95,859 | May 26, 2020, 09:04 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 22, 2020 | Sale | $60.06 | 40,867 | 2,454,525 | 76,247 | May 26, 2020, 09:04 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 21, 2020 | Sale | $59.99 | 2,800 | 167,986 | 76,247 | May 26, 2020, 09:04 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 26, 2020 | Sale | $60.34 | 19,612 | 1,183,423 | 76,247 | May 26, 2020, 09:04 PM |
| Schall Thomas J. | President and CEO | May 11, 2020 | Option Exercise | $14.31 | 70,608 | 1,010,401 | 2,339,165 | May 12, 2020, 07:50 PM |
| Schall Thomas J. | President and CEO | May 08, 2020 | Option Exercise | $14.31 | 4,201 | 60,116 | 2,272,758 | May 12, 2020, 07:50 PM |
| Schall Thomas J. | President and CEO | May 12, 2020 | Option Exercise | $14.31 | 35,865 | 513,228 | 2,304,422 | May 12, 2020, 07:50 PM |
| Schall Thomas J. | President and CEO | May 08, 2020 | Sale | $55.01 | 4,201 | 231,115 | 2,268,557 | May 12, 2020, 07:50 PM |
| Schall Thomas J. | President and CEO | May 12, 2020 | Sale | $57.75 | 35,865 | 2,071,100 | 2,268,557 | May 12, 2020, 07:50 PM |
| Schall Thomas J. | President and CEO | May 11, 2020 | Sale | $55.51 | 70,608 | 3,919,731 | 2,284,586 | May 12, 2020, 07:50 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 08, 2020 | Option Exercise | $3.57 | 4,312 | 15,394 | 80,559 | May 12, 2020, 07:45 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 11, 2020 | Option Exercise | $3.57 | 34,222 | 122,173 | 110,469 | May 12, 2020, 07:45 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 11, 2020 | Sale | $55.11 | 34,222 | 1,886,135 | 76,247 | May 12, 2020, 07:45 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 08, 2020 | Sale | $50.01 | 4,312 | 215,639 | 76,247 | May 12, 2020, 07:45 PM |
| Schall Thomas J. | President and CEO | May 05, 2020 | Option Exercise | $14.31 | 8,851 | 126,658 | 2,277,408 | May 07, 2020, 08:11 PM |
| Schall Thomas J. | President and CEO | May 05, 2020 | Sale | $55.01 | 8,851 | 486,851 | 2,268,557 | May 07, 2020, 08:11 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 05, 2020 | Option Exercise | $3.57 | 8,860 | 31,630 | 85,107 | May 07, 2020, 07:59 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 05, 2020 | Sale | $55.01 | 8,860 | 487,345 | 76,247 | May 07, 2020, 07:59 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 04, 2020 | Option Exercise | $8.19 | 54,877 | 449,443 | 146,194 | May 06, 2020, 08:19 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 05, 2020 | Option Exercise | $8.19 | 20,123 | 164,807 | 111,440 | May 06, 2020, 08:19 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 04, 2020 | Sale | $54.57 | 54,877 | 2,994,819 | 91,317 | May 06, 2020, 08:19 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 05, 2020 | Sale | $54.73 | 20,123 | 1,101,237 | 91,317 | May 06, 2020, 08:19 PM |
| Parker Geoffrey M. | Director | Mar 23, 2020 | Sale | $36.70 | 30,000 | 1,101,049 | 76,401 | Mar 25, 2020, 06:42 PM |
| Schall Thomas J. | President and CEO | Mar 04, 2020 | Option Exercise | $14.31 | 40,844 | 584,478 | 2,309,401 | Mar 05, 2020, 07:03 PM |
| Schall Thomas J. | President and CEO | Mar 04, 2020 | Sale | $50.35 | 40,844 | 2,056,691 | 2,268,557 | Mar 05, 2020, 07:03 PM |
| Schall Thomas J. | President and CEO | Feb 20, 2020 | Option Exercise | $14.31 | 15,341 | 219,530 | 2,283,898 | Feb 21, 2020, 07:24 PM |
| Schall Thomas J. | President and CEO | Feb 19, 2020 | Option Exercise | $14.31 | 63,340 | 906,395 | 2,331,897 | Feb 21, 2020, 07:24 PM |
| Schall Thomas J. | President and CEO | Feb 19, 2020 | Sale | $50.50 | 63,340 | 3,198,514 | 2,276,280 | Feb 21, 2020, 07:24 PM |
| Schall Thomas J. | President and CEO | Feb 20, 2020 | Sale | $50.21 | 15,341 | 770,296 | 2,268,586 | Feb 21, 2020, 07:24 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 19, 2020 | Option Exercise | $10.86 | 24,200 | 262,812 | 118,380 | Feb 21, 2020, 07:15 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 19, 2020 | Sale | $50.13 | 24,200 | 1,213,221 | 97,380 | Feb 21, 2020, 07:15 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 19, 2020 | Option Exercise | $8.19 | 42,631 | 349,148 | 118,878 | Feb 21, 2020, 07:05 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 19, 2020 | Sale | $50.36 | 42,631 | 2,146,698 | 77,410 | Feb 21, 2020, 07:05 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 13, 2020 | Option Exercise | $9.76 | 45,300 | 442,029 | 139,480 | Feb 13, 2020, 08:00 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 12, 2020 | Option Exercise | $9.69 | 2,500 | 24,213 | 96,680 | Feb 13, 2020, 08:00 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 11, 2020 | Option Exercise | $10.68 | 3,000 | 32,046 | 97,180 | Feb 13, 2020, 08:00 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 13, 2020 | Sale | $49.61 | 45,300 | 2,247,147 | 94,180 | Feb 13, 2020, 08:00 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 12, 2020 | Sale | $49.51 | 2,500 | 123,776 | 94,180 | Feb 13, 2020, 08:00 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 11, 2020 | Sale | $49.50 | 3,000 | 148,510 | 94,180 | Feb 13, 2020, 08:00 PM |
| Kwan Pui San | Principal Acctg Officer | Feb 11, 2020 | Sale | $49.15 | 18,941 | 930,888 | 493 | Feb 13, 2020, 07:50 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 06, 2020 | Option Exercise | $8.19 | 36,850 | 301,801 | 113,097 | Feb 10, 2020, 07:53 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 06, 2020 | Sale | $47.31 | 36,850 | 1,743,340 | 76,247 | Feb 10, 2020, 07:53 PM |
| Schall Thomas J. | President and CEO | Feb 04, 2020 | Option Exercise | $14.31 | 119,525 | 1,710,403 | 2,388,082 | Feb 06, 2020, 06:51 PM |
| Schall Thomas J. | President and CEO | Feb 04, 2020 | Sale | $45.18 | 119,525 | 5,400,701 | 2,268,557 | Feb 06, 2020, 06:51 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 04, 2020 | Option Exercise | $14.31 | 99,617 | 1,425,519 | 193,797 | Feb 05, 2020, 08:32 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 03, 2020 | Option Exercise | $14.31 | 3,837 | 54,907 | 98,017 | Feb 05, 2020, 08:32 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 03, 2020 | Sale | $44.91 | 3,837 | 172,317 | 94,180 | Feb 05, 2020, 08:32 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 04, 2020 | Sale | $45.10 | 99,617 | 4,492,229 | 94,180 | Feb 05, 2020, 08:32 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 05, 2020 | Option Exercise | $8.19 | 13,150 | 107,698 | 89,397 | Feb 05, 2020, 08:02 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 03, 2020 | Option Exercise | $8.19 | 48,471 | 396,977 | 124,718 | Feb 05, 2020, 08:02 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 05, 2020 | Sale | $47.03 | 13,150 | 618,451 | 76,427 | Feb 05, 2020, 08:02 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 03, 2020 | Sale | $44.47 | 48,471 | 2,155,525 | 76,247 | Feb 05, 2020, 08:02 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 21, 2020 | Option Exercise | $8.19 | 1,259 | 10,311 | 77,506 | Jan 23, 2020, 07:31 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 21, 2020 | Sale | $44.00 | 1,259 | 55,392 | 76,247 | Jan 23, 2020, 07:31 PM |
| Schall Thomas J. | President and CEO | Jan 17, 2020 | Option Exercise | $10.27 | 105,735 | 1,085,898 | 2,374,292 | Jan 17, 2020, 07:55 PM |
| Schall Thomas J. | President and CEO | Jan 16, 2020 | Option Exercise | $10.27 | 30,317 | 311,356 | 2,298,874 | Jan 17, 2020, 07:55 PM |
| Schall Thomas J. | President and CEO | Jan 17, 2020 | Sale | $41.60 | 105,735 | 4,398,272 | 2,290,736 | Jan 17, 2020, 07:55 PM |
| Schall Thomas J. | President and CEO | Jan 16, 2020 | Sale | $41.01 | 30,317 | 1,243,170 | 2,268,557 | Jan 17, 2020, 07:55 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 17, 2020 | Option Exercise | $14.28 | 15,737 | 224,724 | 109,917 | Jan 17, 2020, 07:49 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 16, 2020 | Option Exercise | $14.28 | 47,261 | 674,887 | 141,441 | Jan 17, 2020, 07:49 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 17, 2020 | Sale | $41.03 | 15,737 | 645,730 | 94,180 | Jan 17, 2020, 07:49 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 16, 2020 | Sale | $40.99 | 47,261 | 1,937,101 | 94,180 | Jan 17, 2020, 07:49 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 16, 2020 | Option Exercise | $7.10 | 50,000 | 355,000 | 126,247 | Jan 17, 2020, 07:42 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 16, 2020 | Sale | $40.07 | 50,000 | 2,003,480 | 76,247 | Jan 17, 2020, 07:42 PM |
| Kwan Pui San | Principal Acctg Officer | Jan 16, 2020 | Option Exercise | $8.31 | 89,179 | 740,881 | 108,613 | Jan 17, 2020, 07:36 PM |
| Kwan Pui San | Principal Acctg Officer | Jan 16, 2020 | Sale | $39.91 | 89,179 | 3,559,216 | 52,312 | Jan 17, 2020, 07:36 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 14, 2020 | Option Exercise | $7.10 | 30,145 | 214,029 | 106,392 | Jan 15, 2020, 06:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 13, 2020 | Option Exercise | $7.10 | 86,311 | 612,808 | 162,558 | Jan 15, 2020, 06:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 14, 2020 | Sale | $37.78 | 30,145 | 1,138,908 | 76,247 | Jan 15, 2020, 06:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 13, 2020 | Sale | $37.09 | 86,311 | 3,201,540 | 119,002 | Jan 15, 2020, 06:29 PM |
| Tyree James L | Director | Jan 13, 2020 | Sale | $37.06 | 30,000 | 1,111,686 | 20,060 | Jan 15, 2020, 06:23 PM |
| Kwan Pui San | Principal Acctg Officer | Jan 10, 2020 | Option Exercise | $3.57 | 1,000 | 3,570 | 20,434 | Jan 14, 2020, 07:02 PM |
| Kwan Pui San | Principal Acctg Officer | Jan 10, 2020 | Sale | $39.02 | 1,000 | 39,016 | 19,434 | Jan 14, 2020, 07:02 PM |
| Kwan Pui San | Principal Acctg Officer | Jan 06, 2020 | Option Exercise | $7.69 | 122,912 | 945,642 | 142,346 | Jan 08, 2020, 07:35 PM |
| Kwan Pui San | Principal Acctg Officer | Jan 06, 2020 | Sale | $34.57 | 122,912 | 4,249,007 | 69,390 | Jan 08, 2020, 07:35 PM |
| Schall Thomas J. | President and CEO | Jan 01, 2020 | Option Exercise | $39.55 | 46,965 | 1,857,466 | 2,268,557 | Jan 03, 2020, 05:37 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 01, 2020 | Option Exercise | $39.55 | 18,173 | 718,742 | 94,180 | Jan 03, 2020, 05:27 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 01, 2020 | Option Exercise | $39.55 | 12,786 | 505,686 | 76,247 | Jan 03, 2020, 05:17 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Dec 27, 2019 | Option Exercise | $9.74 | 79,019 | 769,486 | 79,019 | Dec 30, 2019, 07:14 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Dec 20, 2019 | Option Exercise | $6.11 | 30,259 | 184,835 | 65,700 | Dec 23, 2019, 07:34 PM |
| Parker Geoffrey M. | Director | Dec 02, 2019 | Option Exercise | $6.00 | 31,990 | 191,940 | 104,189 | Dec 04, 2019, 06:10 PM |
| Schall Thomas J. | President and CEO | Nov 26, 2019 | Option Exercise | $6.30 | 279,166 | 1,758,746 | 2,508,021 | Nov 27, 2019, 07:34 PM |
| Schall Thomas J. | President and CEO | Nov 26, 2019 | Sale | $31.55 | 279,166 | 8,808,112 | 2,486,380 | Nov 27, 2019, 07:34 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Nov 26, 2019 | Option Exercise | $6.89 | 311,625 | 2,146,410 | 402,942 | Nov 27, 2019, 07:18 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Nov 26, 2019 | Sale | $31.51 | 311,625 | 9,818,230 | 380,781 | Nov 27, 2019, 07:18 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 26, 2019 | Option Exercise | $11.36 | 330,524 | 3,753,261 | 365,965 | Nov 27, 2019, 07:11 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 26, 2019 | Sale | $32.03 | 330,524 | 10,585,167 | 344,131 | Nov 27, 2019, 07:11 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Oct 20, 2019 | Option Exercise | $7.74 | 17,907 | 138,600 | 91,317 | Oct 22, 2019, 06:29 PM |
| Parker Geoffrey M. | Director | May 30, 2019 | Option Exercise | $6.00 | 18,010 | 108,060 | 85,014 | Jun 03, 2019, 06:17 PM |
| Parker Geoffrey M. | Director | May 30, 2019 | Sale | $12.00 | 12,815 | 153,806 | 72,199 | Jun 03, 2019, 06:17 PM |
| SINGH RAJINDER | SVP, Research | Apr 15, 2019 | Option Exercise | $2.10 | 33,000 | 69,300 | 43,614 | Apr 17, 2019, 06:46 PM |
| SINGH RAJINDER | SVP, Research | Apr 15, 2019 | Sale | $12.96 | 33,000 | 427,706 | 10,614 | Apr 17, 2019, 06:46 PM |
| Schall Thomas J. | President and CEO | Mar 29, 2019 | Option Exercise | $6.00 | 5,755 | 34,530 | 2,234,610 | Apr 02, 2019, 07:49 PM |
| Schall Thomas J. | President and CEO | Apr 02, 2019 | Option Exercise | $6.00 | 74,986 | 449,916 | 2,303,841 | Apr 02, 2019, 07:49 PM |
| Schall Thomas J. | President and CEO | Apr 01, 2019 | Option Exercise | $6.00 | 79,259 | 475,554 | 2,308,114 | Apr 02, 2019, 07:49 PM |
| Schall Thomas J. | President and CEO | Apr 02, 2019 | Sale | $13.85 | 74,986 | 1,038,909 | 2,228,855 | Apr 02, 2019, 07:49 PM |
| Schall Thomas J. | President and CEO | Apr 01, 2019 | Sale | $13.58 | 79,259 | 1,076,084 | 2,228,855 | Apr 02, 2019, 07:49 PM |
| Schall Thomas J. | President and CEO | Mar 29, 2019 | Sale | $14.00 | 5,755 | 80,570 | 2,228,855 | Apr 02, 2019, 07:49 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Mar 27, 2019 | Option Exercise | $3.57 | 35,000 | 124,950 | 110,890 | Mar 29, 2019, 08:08 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Mar 27, 2019 | Sale | $13.05 | 35,000 | 456,827 | 75,890 | Mar 29, 2019, 08:08 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Feb 25, 2019 | Option Exercise | $3.57 | 3,037 | 10,842 | 75,890 | Feb 27, 2019, 07:14 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 22, 2019 | Option Exercise | $3.57 | 37,893 | 135,278 | 110,746 | Jan 24, 2019, 06:50 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 22, 2019 | Sale | $12.08 | 37,893 | 457,747 | 72,853 | Jan 24, 2019, 06:50 PM |
| Schall Thomas J. | President and CEO | Jan 10, 2019 | Option Exercise | $6.00 | 36,762 | 220,572 | 2,265,617 | Jan 14, 2019, 07:44 PM |
| Schall Thomas J. | President and CEO | Jan 10, 2019 | Sale | $12.16 | 36,762 | 447,092 | 2,228,855 | Jan 14, 2019, 07:44 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 10, 2019 | Option Exercise | $6.00 | 6,172 | 37,032 | 41,613 | Jan 14, 2019, 07:36 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 10, 2019 | Sale | $12.00 | 6,172 | 74,079 | 35,441 | Jan 14, 2019, 07:36 PM |
| Schall Thomas J. | President and CEO | Jan 07, 2019 | Option Exercise | $6.00 | 7,275 | 43,650 | 2,236,130 | Jan 09, 2019, 08:06 PM |
| Schall Thomas J. | President and CEO | Jan 09, 2019 | Option Exercise | $6.00 | 12,895 | 77,370 | 2,241,750 | Jan 09, 2019, 08:06 PM |
| Schall Thomas J. | President and CEO | Jan 09, 2019 | Sale | $12.00 | 12,895 | 154,771 | 2,228,855 | Jan 09, 2019, 08:06 PM |
| Schall Thomas J. | President and CEO | Jan 07, 2019 | Sale | $12.04 | 7,275 | 87,599 | 2,228,855 | Jan 09, 2019, 08:06 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 09, 2019 | Option Exercise | $6.00 | 8,134 | 48,804 | 43,575 | Jan 09, 2019, 07:56 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 07, 2019 | Option Exercise | $6.00 | 5,069 | 30,414 | 40,510 | Jan 09, 2019, 07:56 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 09, 2019 | Sale | $12.00 | 8,134 | 97,628 | 35,441 | Jan 09, 2019, 07:56 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 07, 2019 | Sale | $12.07 | 5,069 | 61,162 | 35,441 | Jan 09, 2019, 07:56 PM |
| Schall Thomas J. | President and CEO | Jan 01, 2019 | Option Exercise | $10.91 | 52,806 | 576,113 | 2,228,855 | Jan 03, 2019, 09:13 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 01, 2019 | Option Exercise | $10.91 | 24,008 | 261,927 | 72,853 | Jan 03, 2019, 09:00 PM |
| SINGH RAJINDER | SVP, Research | Jan 01, 2019 | Option Exercise | $10.91 | 8,716 | 95,092 | 10,614 | Jan 03, 2019, 08:49 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 01, 2019 | Option Exercise | $10.91 | 13,385 | 146,030 | 35,441 | Jan 03, 2019, 08:42 PM |
| Schall Thomas J. | President and CEO | Nov 07, 2018 | Option Exercise | $6.00 | 7,211 | 43,266 | 2,192,205 | Nov 09, 2018, 06:39 PM |
| Schall Thomas J. | President and CEO | Nov 07, 2018 | Sale | $12.00 | 7,211 | 86,554 | 2,184,994 | Nov 09, 2018, 06:39 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Oct 26, 2018 | Option Exercise | $6.00 | 30,237 | 181,422 | 54,063 | Oct 30, 2018, 06:47 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Oct 26, 2018 | Sale | $11.01 | 30,237 | 332,779 | 23,826 | Oct 30, 2018, 06:47 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Oct 20, 2018 | Option Exercise | $11.41 | 17,940 | 204,695 | 53,528 | Oct 23, 2018, 06:18 PM |
| GLAXOSMITHKLINE PLC | Former 10% holder | Oct 16, 2018 | Sale | $11.69 | 7,343,492 | 85,845,418 | 0 | Oct 18, 2018, 05:03 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 29, 2018 | Option Exercise | $3.57 | 100 | 357 | 38,235 | Jul 03, 2018, 06:51 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 29, 2018 | Sale | $14.10 | 100 | 1,410 | 38,135 | Jul 03, 2018, 06:51 PM |
| Schall Thomas J. | President and CEO | Jun 28, 2018 | Option Exercise | $6.00 | 10,757 | 64,542 | 2,195,751 | Jul 02, 2018, 08:20 PM |
| Schall Thomas J. | President and CEO | Jun 29, 2018 | Option Exercise | $6.00 | 100 | 600 | 2,185,094 | Jul 02, 2018, 08:20 PM |
| Schall Thomas J. | President and CEO | Jun 28, 2018 | Sale | $14.00 | 10,757 | 150,618 | 2,184,994 | Jul 02, 2018, 08:20 PM |
| Schall Thomas J. | President and CEO | Jun 29, 2018 | Sale | $14.10 | 100 | 1,410 | 2,184,994 | Jul 02, 2018, 08:20 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 27, 2018 | Option Exercise | $6.00 | 800 | 4,800 | 24,626 | Jun 29, 2018, 07:36 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 29, 2018 | Option Exercise | $6.00 | 100 | 600 | 23,926 | Jun 29, 2018, 07:36 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 28, 2018 | Option Exercise | $6.00 | 24,279 | 145,674 | 48,105 | Jun 29, 2018, 07:36 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 29, 2018 | Sale | $14.10 | 100 | 1,410 | 23,826 | Jun 29, 2018, 07:36 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 28, 2018 | Sale | $13.67 | 24,279 | 331,991 | 23,826 | Jun 29, 2018, 07:36 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 27, 2018 | Sale | $13.50 | 800 | 10,800 | 23,826 | Jun 29, 2018, 07:36 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 28, 2018 | Option Exercise | $5.66 | 49,507 | 280,015 | 80,635 | Jun 28, 2018, 07:10 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 27, 2018 | Option Exercise | $6.00 | 49,150 | 294,900 | 87,285 | Jun 28, 2018, 07:10 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 26, 2018 | Option Exercise | $6.00 | 850 | 5,100 | 38,985 | Jun 28, 2018, 07:10 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 28, 2018 | Sale | $13.79 | 49,507 | 682,496 | 38,135 | Jun 28, 2018, 07:10 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 27, 2018 | Sale | $13.25 | 49,150 | 651,238 | 38,135 | Jun 28, 2018, 07:10 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jun 26, 2018 | Sale | $13.25 | 850 | 11,263 | 38,135 | Jun 28, 2018, 07:10 PM |
| Schall Thomas J. | President and CEO | May 23, 2018 | Option Exercise | $6.00 | 27,928 | 167,568 | 2,212,922 | May 23, 2018, 09:53 PM |
| Schall Thomas J. | President and CEO | May 22, 2018 | Option Exercise | $6.00 | 30,932 | 185,592 | 2,215,926 | May 23, 2018, 09:53 PM |
| Schall Thomas J. | President and CEO | May 21, 2018 | Option Exercise | $6.00 | 33,938 | 203,628 | 2,218,932 | May 23, 2018, 09:53 PM |
| Schall Thomas J. | President and CEO | May 23, 2018 | Sale | $13.01 | 27,928 | 363,293 | 2,184,994 | May 23, 2018, 09:53 PM |
| Schall Thomas J. | President and CEO | May 22, 2018 | Sale | $13.00 | 30,932 | 402,150 | 2,184,994 | May 23, 2018, 09:53 PM |
| Schall Thomas J. | President and CEO | May 21, 2018 | Sale | $12.55 | 33,938 | 426,022 | 2,202,792 | May 23, 2018, 09:53 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 21, 2018 | Option Exercise | $6.00 | 2,709 | 16,254 | 26,535 | May 23, 2018, 09:52 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 21, 2018 | Sale | $13.00 | 2,709 | 35,217 | 23,826 | May 23, 2018, 09:52 PM |
| Schall Thomas J. | President and CEO | May 15, 2018 | Option Exercise | $6.00 | 100,000 | 600,000 | 2,284,994 | May 17, 2018, 07:38 PM |
| Schall Thomas J. | President and CEO | May 17, 2018 | Option Exercise | $6.00 | 17,798 | 106,788 | 2,202,792 | May 17, 2018, 07:38 PM |
| Schall Thomas J. | President and CEO | May 16, 2018 | Option Exercise | $6.00 | 82,202 | 493,212 | 2,267,196 | May 17, 2018, 07:38 PM |
| Schall Thomas J. | President and CEO | May 17, 2018 | Sale | $12.14 | 17,798 | 216,137 | 2,184,994 | May 17, 2018, 07:38 PM |
| Schall Thomas J. | President and CEO | May 16, 2018 | Sale | $12.26 | 82,202 | 1,007,665 | 2,184,994 | May 17, 2018, 07:38 PM |
| Schall Thomas J. | President and CEO | May 15, 2018 | Sale | $11.32 | 100,000 | 1,132,060 | 2,184,994 | May 17, 2018, 07:38 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 16, 2018 | Option Exercise | $6.00 | 50,000 | 300,000 | 57,160 | May 17, 2018, 07:34 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 16, 2018 | Sale | $11.81 | 50,000 | 590,637 | 23,826 | May 17, 2018, 07:34 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 15, 2018 | Option Exercise | $6.00 | 8,306 | 49,836 | 46,441 | May 17, 2018, 07:29 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 15, 2018 | Sale | $11.14 | 8,306 | 92,526 | 38,135 | May 17, 2018, 07:29 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 08, 2018 | Option Exercise | $6.00 | 65,328 | 391,968 | 103,463 | May 10, 2018, 07:05 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 08, 2018 | Sale | $11.53 | 65,328 | 752,925 | 38,135 | May 10, 2018, 07:05 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 02, 2018 | Option Exercise | $6.00 | 1,366 | 8,196 | 39,501 | May 04, 2018, 05:36 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | May 02, 2018 | Sale | $11.50 | 1,366 | 15,709 | 38,135 | May 04, 2018, 05:36 PM |
| Schall Thomas J. | President and CEO | May 01, 2018 | Option Exercise | $6.00 | 17,127 | 102,762 | 2,202,121 | May 03, 2018, 08:38 PM |
| Schall Thomas J. | President and CEO | May 02, 2018 | Option Exercise | $6.00 | 32,873 | 197,238 | 2,217,867 | May 03, 2018, 08:38 PM |
| Schall Thomas J. | President and CEO | May 02, 2018 | Sale | $11.03 | 32,873 | 362,451 | 2,184,994 | May 03, 2018, 08:38 PM |
| Schall Thomas J. | President and CEO | May 01, 2018 | Sale | $11.00 | 17,127 | 188,407 | 2,184,994 | May 03, 2018, 08:38 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 02, 2018 | Option Exercise | $6.00 | 38,089 | 228,534 | 61,915 | May 03, 2018, 08:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 01, 2018 | Option Exercise | $6.00 | 11,911 | 71,466 | 35,737 | May 03, 2018, 08:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 02, 2018 | Sale | $11.02 | 38,089 | 419,886 | 23,826 | May 03, 2018, 08:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 01, 2018 | Sale | $11.00 | 11,911 | 131,027 | 23,826 | May 03, 2018, 08:29 PM |
| Schall Thomas J. | President and CEO | Jan 01, 2018 | Option Exercise | $5.95 | 36,717 | 218,466 | 2,184,994 | Jan 03, 2018, 07:47 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 01, 2018 | Option Exercise | $5.95 | 19,049 | 113,342 | 38,135 | Jan 03, 2018, 07:38 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 01, 2018 | Option Exercise | $5.95 | 10,898 | 64,843 | 23,826 | Jan 03, 2018, 07:31 PM |
| SINGH RAJINDER | SVP, Research | Jan 01, 2018 | Option Exercise | $5.95 | 5,670 | 33,736 | 4,330 | Jan 03, 2018, 07:24 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Oct 20, 2017 | Option Exercise | $7.03 | 18,759 | 131,876 | 23,851 | Oct 24, 2017, 05:21 PM |
| LUCAS ROGER C | Director | Aug 01, 2017 | Sale | $10.07 | 2,250 | 22,667 | 93,846 | Aug 03, 2017, 06:11 PM |
| Bekker Petrus | Chief Medical Officer | Jul 12, 2017 | Option Exercise | $6.73 | 30,000 | 201,874 | 69,839 | Jul 13, 2017, 07:46 PM |
| Bekker Petrus | Chief Medical Officer | Jul 11, 2017 | Option Exercise | $6.78 | 30,000 | 203,326 | 83,715 | Jul 13, 2017, 07:46 PM |
| Bekker Petrus | Chief Medical Officer | Jul 13, 2017 | Option Exercise | $7.93 | 16,013 | 126,909 | 71,964 | Jul 13, 2017, 07:46 PM |
| Bekker Petrus | Chief Medical Officer | Jul 12, 2017 | Sale | $9.98 | 30,000 | 299,280 | 59,839 | Jul 13, 2017, 07:46 PM |
| Bekker Petrus | Chief Medical Officer | Jul 11, 2017 | Sale | $9.78 | 30,000 | 293,326 | 59,839 | Jul 13, 2017, 07:46 PM |
| Bekker Petrus | Chief Medical Officer | Jul 13, 2017 | Sale | $10.21 | 16,013 | 163,464 | 59,839 | Jul 13, 2017, 07:46 PM |
| Bekker Petrus | Chief Medical Officer | Jul 07, 2017 | Option Exercise | $6.30 | 19,587 | 123,398 | 79,426 | Jul 10, 2017, 07:59 PM |
| Bekker Petrus | Chief Medical Officer | Jul 10, 2017 | Option Exercise | $6.30 | 290 | 1,827 | 60,129 | Jul 10, 2017, 07:59 PM |
| Bekker Petrus | Chief Medical Officer | Jul 10, 2017 | Sale | $9.30 | 290 | 2,697 | 59,839 | Jul 10, 2017, 07:59 PM |
| Bekker Petrus | Chief Medical Officer | Jul 07, 2017 | Sale | $9.30 | 19,587 | 182,159 | 59,839 | Jul 10, 2017, 07:59 PM |
| Bekker Petrus | Chief Medical Officer | Jun 28, 2017 | Option Exercise | $7.10 | 30,000 | 213,000 | 89,839 | Jun 30, 2017, 07:32 PM |
| Bekker Petrus | Chief Medical Officer | Jun 30, 2017 | Option Exercise | $6.62 | 30,000 | 198,593 | 77,848 | Jun 30, 2017, 07:32 PM |
| Bekker Petrus | Chief Medical Officer | Jun 29, 2017 | Option Exercise | $7.10 | 5,509 | 39,114 | 65,348 | Jun 30, 2017, 07:32 PM |
| Bekker Petrus | Chief Medical Officer | Jun 30, 2017 | Sale | $9.23 | 30,000 | 276,870 | 59,839 | Jun 30, 2017, 07:32 PM |
| Bekker Petrus | Chief Medical Officer | Jun 29, 2017 | Sale | $9.11 | 5,509 | 50,167 | 59,839 | Jun 30, 2017, 07:32 PM |
| Bekker Petrus | Chief Medical Officer | Jun 28, 2017 | Sale | $9.12 | 30,000 | 273,669 | 59,839 | Jun 30, 2017, 07:32 PM |
| LUCAS ROGER C | Director | May 01, 2017 | Sale | $7.31 | 4,000 | 29,228 | 62,822 | May 03, 2017, 07:06 PM |
| LUCAS ROGER C | Director | Feb 01, 2017 | Sale | $7.32 | 4,000 | 29,290 | 66,822 | Feb 03, 2017, 05:42 PM |
| Bekker Petrus | Chief Medical Officer | Jan 01, 2017 | Option Exercise | $7.40 | 7,088 | 52,451 | 59,839 | Jan 04, 2017, 08:14 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 01, 2017 | Option Exercise | $7.40 | 4,442 | 32,871 | 16,391 | Jan 04, 2017, 08:07 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 03, 2017 | Option Exercise | $4.30 | 26,821 | 115,330 | 43,212 | Jan 04, 2017, 08:07 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 03, 2017 | Sale | $7.51 | 26,821 | 201,305 | 16,391 | Jan 04, 2017, 08:07 PM |
| KANAYA SUSAN M | EVP, CFO and Sec. | Jan 01, 2017 | Option Exercise | $7.40 | 10,723 | 79,350 | 9,277 | Jan 04, 2017, 06:20 PM |
| Schall Thomas J. | President and CEO | Jan 01, 2017 | Option Exercise | $7.40 | 17,955 | 132,867 | 2,155,045 | Jan 04, 2017, 06:13 PM |
| Bekker Petrus | Chief Medical Officer | Dec 16, 2016 | Option Exercise | $6.21 | 8,712 | 54,112 | 60,262 | Dec 20, 2016, 05:32 PM |
| Bekker Petrus | Chief Medical Officer | Dec 16, 2016 | Sale | $8.74 | 8,712 | 76,120 | 53,594 | Dec 20, 2016, 05:32 PM |
| Bekker Petrus | Chief Medical Officer | Dec 05, 2016 | Option Exercise | $6.00 | 30,000 | 180,000 | 83,594 | Dec 07, 2016, 07:15 PM |
| Bekker Petrus | Chief Medical Officer | Dec 05, 2016 | Sale | $8.50 | 30,000 | 255,000 | 53,594 | Dec 07, 2016, 07:15 PM |
| Bekker Petrus | Chief Medical Officer | Nov 22, 2016 | Option Exercise | $6.30 | 1,250 | 7,875 | 54,844 | Nov 23, 2016, 06:33 PM |
| Bekker Petrus | Chief Medical Officer | Nov 22, 2016 | Sale | $8.30 | 1,250 | 10,375 | 53,594 | Nov 23, 2016, 06:33 PM |
| Bekker Petrus | Chief Medical Officer | Nov 09, 2016 | Option Exercise | $6.00 | 634 | 3,804 | 54,228 | Nov 14, 2016, 04:57 PM |
| Bekker Petrus | Chief Medical Officer | Nov 11, 2016 | Option Exercise | $6.00 | 2,698 | 16,188 | 56,292 | Nov 14, 2016, 04:57 PM |
| Bekker Petrus | Chief Medical Officer | Nov 10, 2016 | Option Exercise | $6.00 | 30,000 | 180,000 | 83,594 | Nov 14, 2016, 04:57 PM |
| Bekker Petrus | Chief Medical Officer | Nov 11, 2016 | Sale | $8.00 | 2,698 | 21,584 | 53,594 | Nov 14, 2016, 04:57 PM |
| Bekker Petrus | Chief Medical Officer | Nov 10, 2016 | Sale | $8.00 | 30,000 | 240,000 | 53,594 | Nov 14, 2016, 04:57 PM |
| Bekker Petrus | Chief Medical Officer | Nov 09, 2016 | Sale | $8.00 | 634 | 5,072 | 53,594 | Nov 14, 2016, 04:57 PM |
| LUCAS ROGER C | Director | Nov 01, 2016 | Sale | $6.10 | 4,000 | 24,411 | 70,822 | Nov 03, 2016, 05:47 PM |
| LUCAS ROGER C | Director | Sep 01, 2016 | Sale | $5.07 | 4,000 | 20,262 | 74,822 | Sep 02, 2016, 05:47 PM |
| Tyree James L | Director | May 23, 2016 | Sale | $4.39 | 5,544 | 24,337 | 20,575 | May 24, 2016, 07:06 PM |
| Edwards Thomas A. | Director | May 17, 2016 | Buy | $4.05 | 50,000 | 202,500 | 91,977 | May 18, 2016, 03:54 PM |
| Edwards Thomas A. | Director | May 16, 2016 | Buy | $4.05 | 25,000 | 101,213 | 41,977 | May 16, 2016, 09:47 PM |
| Parker Geoffrey M. | Director | May 13, 2016 | Buy | $4.03 | 40,000 | 161,388 | 99,600 | May 13, 2016, 04:03 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 22, 2016 | Option Exercise | $2.00 | 15,127 | 30,254 | 15,127 | Jan 22, 2016, 07:23 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 21, 2016 | Option Exercise | $2.00 | 10,637 | 21,274 | 10,637 | Jan 22, 2016, 07:23 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 22, 2016 | Sale | $4.06 | 15,127 | 61,429 | 0 | Jan 22, 2016, 07:23 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 21, 2016 | Sale | $4.02 | 10,637 | 42,726 | 0 | Jan 22, 2016, 07:23 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 19, 2016 | Option Exercise | $2.00 | 6,134 | 12,268 | 6,134 | Jan 20, 2016, 08:12 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 15, 2016 | Option Exercise | $2.00 | 300 | 600 | 300 | Jan 20, 2016, 08:12 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 20, 2016 | Option Exercise | $2.00 | 14,971 | 29,942 | 14,971 | Jan 20, 2016, 08:12 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 19, 2016 | Sale | $4.05 | 6,134 | 24,826 | 0 | Jan 20, 2016, 08:12 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 15, 2016 | Sale | $4.00 | 300 | 1,200 | 0 | Jan 20, 2016, 08:12 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 20, 2016 | Sale | $4.10 | 14,971 | 61,341 | 0 | Jan 20, 2016, 08:12 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 08, 2016 | Option Exercise | $2.00 | 10,224 | 20,448 | 10,224 | Jan 12, 2016, 08:21 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 08, 2016 | Sale | $5.12 | 10,224 | 52,347 | 0 | Jan 12, 2016, 08:21 PM |
| Parker Geoffrey M. | Director | Jan 11, 2016 | Buy | $4.63 | 20,000 | 92,512 | 59,600 | Jan 11, 2016, 07:26 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 06, 2016 | Option Exercise | $2.00 | 2,776 | 5,552 | 2,776 | Jan 06, 2016, 06:29 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 05, 2016 | Option Exercise | $2.00 | 34,341 | 68,682 | 34,341 | Jan 06, 2016, 06:29 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 04, 2016 | Option Exercise | $2.00 | 10,490 | 20,980 | 10,490 | Jan 06, 2016, 06:29 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 06, 2016 | Sale | $6.55 | 2,776 | 18,195 | 0 | Jan 06, 2016, 06:29 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 05, 2016 | Sale | $6.90 | 34,341 | 236,874 | 0 | Jan 06, 2016, 06:29 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jan 04, 2016 | Sale | $7.38 | 10,490 | 77,379 | 0 | Jan 06, 2016, 06:29 PM |
| Parker Geoffrey M. | Director | Dec 11, 2015 | Buy | $7.30 | 4,621 | 33,724 | 39,600 | Dec 14, 2015, 11:52 AM |
| Parker Geoffrey M. | Director | Dec 10, 2015 | Buy | $7.23 | 15,379 | 111,202 | 34,979 | Dec 14, 2015, 11:52 AM |
| BVF PARTNERS L P/IL | See Explanation of Responses | Nov 03, 2015 | Sale | $6.98 | 73,000 | 509,343 | 2,671,577 | Nov 05, 2015, 05:34 PM |
| BVF PARTNERS L P/IL | See Explanation of Responses | Nov 04, 2015 | Sale | $7.00 | 287,000 | 2,009,057 | 2,384,577 | Nov 05, 2015, 05:34 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 02, 2015 | Sale | $6.97 | 50,000 | 348,515 | 2,744,577 | Nov 02, 2015, 05:49 PM |
| BVF PARTNERS L P/IL | 10% Owner | Jun 10, 2015 | Sale | $9.01 | 31,000 | 279,229 | 2,794,577 | Jun 11, 2015, 08:06 PM |
| BVF PARTNERS L P/IL | 10% Owner | Jun 09, 2015 | Sale | $9.00 | 924,700 | 8,322,393 | 2,825,577 | Jun 11, 2015, 08:06 PM |
| Parker Geoffrey M. | Director | May 27, 2015 | Sale | $7.51 | 13,513 | 101,515 | 13,514 | May 29, 2015, 05:46 PM |
| KLEIN IRA | Director | May 22, 2015 | Sale | $7.44 | 10,811 | 80,484 | 16,216 | May 26, 2015, 05:41 PM |
| Tyree James L | Director | May 22, 2015 | Sale | $7.45 | 12,703 | 94,593 | 14,324 | May 26, 2015, 05:31 PM |
| Schall Thomas J. | President and CEO | Apr 01, 2015 | Option Exercise | $0.60 | 6,527 | 3,916 | 2,155,194 | Apr 01, 2015, 06:26 PM |
| Schall Thomas J. | President and CEO | Mar 31, 2015 | Option Exercise | $0.60 | 16,540 | 9,924 | 2,165,207 | Apr 01, 2015, 06:26 PM |
| Schall Thomas J. | President and CEO | Mar 30, 2015 | Option Exercise | $0.60 | 1,200 | 720 | 2,149,867 | Apr 01, 2015, 06:26 PM |
| Schall Thomas J. | President and CEO | Apr 01, 2015 | Sale | $7.36 | 6,527 | 48,047 | 2,148,667 | Apr 01, 2015, 06:26 PM |
| Schall Thomas J. | President and CEO | Mar 31, 2015 | Sale | $7.55 | 16,540 | 124,920 | 2,148,667 | Apr 01, 2015, 06:26 PM |
| Schall Thomas J. | President and CEO | Mar 30, 2015 | Sale | $7.51 | 1,200 | 9,009 | 2,148,667 | Apr 01, 2015, 06:26 PM |
| Schall Thomas J. | President and CEO | Mar 25, 2015 | Option Exercise | $0.60 | 900 | 540 | 2,149,567 | Mar 27, 2015, 08:20 PM |
| Schall Thomas J. | President and CEO | Mar 25, 2015 | Sale | $7.57 | 900 | 6,812 | 2,148,667 | Mar 27, 2015, 08:20 PM |
| Schall Thomas J. | President and CEO | Mar 20, 2015 | Option Exercise | $0.60 | 14,315 | 8,589 | 2,162,982 | Mar 24, 2015, 07:30 PM |
| Schall Thomas J. | President and CEO | Mar 24, 2015 | Option Exercise | $0.60 | 16,765 | 10,059 | 2,165,432 | Mar 24, 2015, 07:30 PM |
| Schall Thomas J. | President and CEO | Mar 23, 2015 | Option Exercise | $0.60 | 19,291 | 11,575 | 2,167,958 | Mar 24, 2015, 07:30 PM |
| Schall Thomas J. | President and CEO | Mar 20, 2015 | Sale | $8.00 | 14,315 | 114,458 | 2,148,667 | Mar 24, 2015, 07:30 PM |
| Schall Thomas J. | President and CEO | Mar 24, 2015 | Sale | $7.80 | 16,765 | 130,839 | 2,148,667 | Mar 24, 2015, 07:30 PM |
| Schall Thomas J. | President and CEO | Mar 23, 2015 | Sale | $7.77 | 19,291 | 149,858 | 2,148,667 | Mar 24, 2015, 07:30 PM |
| Schall Thomas J. | President and CEO | Mar 19, 2015 | Option Exercise | $0.60 | 8,467 | 5,080 | 2,157,134 | Mar 20, 2015, 04:22 PM |
| Schall Thomas J. | President and CEO | Mar 18, 2015 | Option Exercise | $0.60 | 9,679 | 5,807 | 2,158,346 | Mar 20, 2015, 04:22 PM |
| Schall Thomas J. | President and CEO | Mar 19, 2015 | Sale | $8.24 | 8,467 | 69,794 | 2,148,667 | Mar 20, 2015, 04:22 PM |
| Schall Thomas J. | President and CEO | Mar 18, 2015 | Sale | $8.42 | 9,679 | 81,516 | 2,148,667 | Mar 20, 2015, 04:22 PM |
| Schall Thomas J. | President and CEO | Mar 17, 2015 | Option Exercise | $0.60 | 8,590 | 5,154 | 2,157,257 | Mar 18, 2015, 04:50 PM |
| Schall Thomas J. | President and CEO | Mar 16, 2015 | Option Exercise | $0.60 | 22,726 | 13,636 | 2,171,393 | Mar 18, 2015, 04:50 PM |
| Schall Thomas J. | President and CEO | Mar 16, 2015 | Sale | $8.54 | 22,726 | 194,128 | 2,148,667 | Mar 18, 2015, 04:50 PM |
| Schall Thomas J. | President and CEO | Mar 17, 2015 | Sale | $8.58 | 8,590 | 73,692 | 2,148,667 | Mar 18, 2015, 04:50 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 06, 2015 | Option Exercise | $0.60 | 17,721 | 10,633 | 30,221 | Mar 09, 2015, 07:13 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 05, 2015 | Option Exercise | $0.60 | 8,645 | 5,187 | 21,145 | Mar 09, 2015, 07:13 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 09, 2015 | Option Exercise | $0.60 | 7,759 | 4,655 | 20,259 | Mar 09, 2015, 07:13 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 05, 2015 | Sale | $7.99 | 8,645 | 69,069 | 12,500 | Mar 09, 2015, 07:13 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 09, 2015 | Sale | $7.74 | 7,759 | 60,079 | 12,500 | Mar 09, 2015, 07:13 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 06, 2015 | Sale | $7.76 | 17,721 | 137,476 | 12,500 | Mar 09, 2015, 07:13 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 03, 2015 | Option Exercise | $0.60 | 5,943 | 3,566 | 18,443 | Mar 04, 2015, 08:19 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 02, 2015 | Option Exercise | $0.60 | 14,390 | 8,634 | 26,890 | Mar 04, 2015, 08:19 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 04, 2015 | Option Exercise | $0.60 | 20,542 | 12,325 | 22,043 | Mar 04, 2015, 08:19 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 02, 2015 | Sale | $8.13 | 14,390 | 116,975 | 12,500 | Mar 04, 2015, 08:19 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 04, 2015 | Sale | $7.92 | 20,542 | 162,686 | 12,500 | Mar 04, 2015, 08:19 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 03, 2015 | Sale | $7.81 | 5,943 | 46,430 | 12,500 | Mar 04, 2015, 08:19 PM |
| Duliege Anne-Marie | EVP, Chief of Strategic Dev. | Nov 18, 2014 | Sale | $4.71 | 4,970 | 23,432 | 0 | Nov 20, 2014, 07:54 PM |
| Schall Thomas J. | President and CEO | May 01, 2014 | Option Exercise | $0.60 | 27,726 | 16,636 | 2,176,393 | May 02, 2014, 05:41 PM |
| Schall Thomas J. | President and CEO | May 01, 2014 | Sale | $5.59 | 27,726 | 154,875 | 2,148,667 | May 02, 2014, 05:41 PM |
| Schall Thomas J. | President and CEO | Apr 29, 2014 | Option Exercise | $0.60 | 14,041 | 8,425 | 2,162,708 | Apr 30, 2014, 07:03 PM |
| Schall Thomas J. | President and CEO | Apr 28, 2014 | Option Exercise | $0.60 | 18,233 | 10,940 | 2,166,900 | Apr 30, 2014, 07:03 PM |
| Schall Thomas J. | President and CEO | Apr 28, 2014 | Sale | $5.33 | 18,233 | 97,127 | 2,148,667 | Apr 30, 2014, 07:03 PM |
| Schall Thomas J. | President and CEO | Apr 29, 2014 | Sale | $5.46 | 14,041 | 76,595 | 2,148,667 | Apr 30, 2014, 07:03 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Apr 22, 2014 | Option Exercise | $0.60 | 14,712 | 8,827 | 27,212 | Apr 24, 2014, 07:45 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Apr 22, 2014 | Sale | $5.72 | 14,712 | 84,195 | 12,500 | Apr 24, 2014, 07:45 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 05, 2013 | Sale | $13.92 | 6,250 | 87,009 | 12,500 | Apr 24, 2014, 07:45 PM |
| Schall Thomas J. | President and CEO | Mar 17, 2014 | Option Exercise | $0.60 | 20,000 | 12,000 | 2,168,707 | Mar 19, 2014, 06:14 PM |
| Schall Thomas J. | President and CEO | Mar 17, 2014 | Sale | $7.25 | 20,000 | 145,000 | 2,148,707 | Mar 19, 2014, 06:14 PM |
| Schall Thomas J. | President and CEO | Feb 18, 2014 | Option Exercise | $0.60 | 20,000 | 12,000 | 2,168,707 | Feb 20, 2014, 06:36 PM |
| Schall Thomas J. | President and CEO | Feb 18, 2014 | Sale | $7.05 | 20,000 | 140,932 | 2,148,707 | Feb 20, 2014, 06:36 PM |
| Parker Geoffrey M. | Director | Dec 06, 2013 | Buy | $5.15 | 15,000 | 77,265 | 15,000 | Dec 09, 2013, 03:32 PM |
| Parker Geoffrey M. | Director | Dec 06, 2013 | Buy | $5.15 | 5,000 | 25,757 | 9,600 | Dec 09, 2013, 03:32 PM |
| BVF PARTNERS L P/IL | 10% Owner | Dec 05, 2013 | Buy | $5.03 | 124,300 | 624,806 | 2,162,381 | Dec 05, 2013, 05:27 PM |
| BVF PARTNERS L P/IL | 10% Owner | Dec 03, 2013 | Buy | $4.98 | 65,500 | 326,347 | 2,079,532 | Dec 05, 2013, 05:27 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 04, 2013 | Buy | $4.90 | 5,500 | 26,944 | 1,111,233 | Nov 06, 2013, 05:40 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 06, 2013 | Buy | $4.69 | 20,356 | 95,409 | 2,030,207 | Nov 06, 2013, 05:40 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 05, 2013 | Buy | $4.97 | 110,210 | 547,446 | 2,018,222 | Nov 06, 2013, 05:40 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 31, 2013 | Buy | $4.97 | 124,582 | 618,587 | 1,937,290 | Nov 01, 2013, 04:54 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 30, 2013 | Buy | $5.04 | 141,083 | 711,016 | 1,857,292 | Nov 01, 2013, 04:54 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 01, 2013 | Buy | $4.92 | 70,560 | 347,205 | 1,982,696 | Nov 01, 2013, 04:54 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 09, 2013 | Buy | $5.26 | 82,835 | 435,538 | 1,766,548 | Oct 10, 2013, 05:07 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 08, 2013 | Buy | $5.35 | 1,206,519 | 6,451,372 | 1,713,277 | Oct 10, 2013, 05:07 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 03, 2013 | Buy | $5.49 | 109,425 | 601,203 | 938,839 | Oct 07, 2013, 05:01 PM |
| FECZKO JOSEPH M | Director | Sep 13, 2013 | Buy | $6.03 | 10,000 | 60,257 | 10,000 | Sep 16, 2013, 08:19 PM |
| BVF PARTNERS L P/IL | 10% Owner | Sep 13, 2013 | Buy | $6.09 | 9,677 | 58,924 | 868,013 | Sep 13, 2013, 05:30 PM |
| BVF PARTNERS L P/IL | 10% Owner | Sep 11, 2013 | Buy | $5.94 | 315,958 | 1,877,201 | 861,706 | Sep 13, 2013, 05:30 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Aug 13, 2013 | Option Exercise | $1.81 | 5,459 | 9,873 | 22,426 | Aug 14, 2013, 06:13 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Aug 13, 2013 | Sale | $12.90 | 5,459 | 70,427 | 18,750 | Aug 14, 2013, 06:13 PM |
| Bekker Petrus | SVP of Medical & Clinical | Aug 07, 2013 | Option Exercise | $6.00 | 5,000 | 30,000 | 58,594 | Aug 09, 2013, 06:51 PM |
| Bekker Petrus | SVP of Medical & Clinical | Aug 07, 2013 | Sale | $13.26 | 5,000 | 66,283 | 53,594 | Aug 09, 2013, 06:51 PM |
| LUCAS ROGER C | Director | Aug 05, 2013 | Sale | $13.42 | 5,000 | 67,083 | 40,000 | Aug 05, 2013, 06:15 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Aug 01, 2013 | Sale | $13.82 | 6,250 | 86,378 | 18,750 | Aug 05, 2013, 06:14 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jul 17, 2013 | Option Exercise | $1.81 | 5,459 | 9,873 | 28,676 | Jul 19, 2013, 05:27 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jul 17, 2013 | Sale | $14.52 | 5,459 | 79,239 | 25,000 | Jul 19, 2013, 05:27 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jul 17, 2013 | Option Exercise | $6.00 | 10,000 | 60,000 | 58,594 | Jul 19, 2013, 05:24 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jul 17, 2013 | Sale | $14.54 | 10,000 | 145,394 | 53,594 | Jul 19, 2013, 05:24 PM |
| Schall Thomas J. | President and CEO | Jul 16, 2013 | Sale | $14.54 | 2,585 | 37,595 | 2,148,687 | Jul 17, 2013, 06:12 PM |
| Schall Thomas J. | President and CEO | Jul 15, 2013 | Sale | $14.37 | 19,504 | 280,360 | 2,151,272 | Jul 17, 2013, 06:12 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jul 02, 2013 | Sale | $13.88 | 6,250 | 86,758 | 25,000 | Jul 03, 2013, 06:24 PM |
| Schall Thomas J. | President and CEO | Jul 01, 2013 | Sale | $14.50 | 311 | 4,510 | 2,170,776 | Jul 03, 2013, 06:23 PM |
| LUCAS ROGER C | Director | Jul 03, 2013 | Sale | $13.43 | 5,000 | 67,157 | 45,000 | Jul 03, 2013, 06:22 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jun 28, 2013 | Option Exercise | $2.00 | 36,942 | 73,884 | 36,942 | Jul 02, 2013, 05:36 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Jun 28, 2013 | Sale | $14.31 | 36,942 | 528,658 | 0 | Jul 02, 2013, 05:36 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jun 26, 2013 | Option Exercise | $6.00 | 117 | 702 | 53,711 | Jun 27, 2013, 07:28 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jun 25, 2013 | Option Exercise | $6.00 | 1,867 | 11,202 | 55,461 | Jun 27, 2013, 07:28 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jun 27, 2013 | Option Exercise | $6.00 | 3,016 | 18,096 | 56,610 | Jun 27, 2013, 07:28 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jun 26, 2013 | Sale | $14.00 | 117 | 1,638 | 53,594 | Jun 27, 2013, 07:28 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jun 25, 2013 | Sale | $14.00 | 1,867 | 26,138 | 53,594 | Jun 27, 2013, 07:28 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jun 27, 2013 | Sale | $14.00 | 3,016 | 42,224 | 53,594 | Jun 27, 2013, 07:28 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 21, 2013 | Sale | $13.00 | 6,250 | 81,250 | 31,250 | Jun 25, 2013, 09:10 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 18, 2013 | Option Exercise | $4.30 | 1,783 | 7,667 | 39,283 | Jun 20, 2013, 07:40 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jun 18, 2013 | Sale | $12.47 | 1,783 | 22,228 | 37,500 | Jun 20, 2013, 07:40 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jun 17, 2013 | Option Exercise | $6.00 | 5,000 | 30,000 | 58,594 | Jun 19, 2013, 07:12 PM |
| Bekker Petrus | SVP of Medical & Clinical | Jun 17, 2013 | Sale | $12.00 | 5,000 | 60,001 | 53,594 | Jun 19, 2013, 07:12 PM |
| LUCAS ROGER C | Director | Jun 03, 2013 | Sale | $13.32 | 5,000 | 66,594 | 51,502 | Jun 05, 2013, 04:53 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | May 29, 2013 | Option Exercise | $2.00 | 2,117 | 4,234 | 2,117 | May 31, 2013, 06:02 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | May 30, 2013 | Option Exercise | $2.00 | 10,653 | 21,306 | 10,653 | May 31, 2013, 06:02 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | May 30, 2013 | Sale | $14.28 | 10,653 | 152,140 | 0 | May 31, 2013, 06:02 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | May 29, 2013 | Sale | $14.27 | 2,117 | 30,211 | 0 | May 31, 2013, 06:02 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 28, 2013 | Option Exercise | $0.60 | 3,676 | 2,206 | 41,176 | May 29, 2013, 07:47 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 28, 2013 | Sale | $14.10 | 3,676 | 51,832 | 37,500 | May 29, 2013, 07:47 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 23, 2013 | Option Exercise | $6.00 | 4,718 | 28,308 | 58,312 | May 28, 2013, 05:39 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 24, 2013 | Option Exercise | $6.00 | 82 | 492 | 53,676 | May 28, 2013, 05:39 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 24, 2013 | Sale | $14.00 | 82 | 1,148 | 53,594 | May 28, 2013, 05:39 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 23, 2013 | Sale | $14.00 | 4,718 | 66,054 | 53,594 | May 28, 2013, 05:39 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 20, 2013 | Option Exercise | $6.00 | 200 | 1,200 | 53,794 | May 22, 2013, 07:14 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 20, 2013 | Sale | $14.00 | 200 | 2,800 | 53,594 | May 22, 2013, 07:14 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 17, 2013 | Option Exercise | $6.00 | 5,000 | 30,000 | 58,594 | May 17, 2013, 08:00 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 15, 2013 | Option Exercise | $6.00 | 10,000 | 60,000 | 63,594 | May 17, 2013, 08:00 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 17, 2013 | Sale | $13.59 | 5,000 | 67,973 | 53,594 | May 17, 2013, 08:00 PM |
| Bekker Petrus | SVP of Medical & Clinical | May 15, 2013 | Sale | $14.16 | 10,000 | 141,598 | 53,594 | May 17, 2013, 08:00 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 15, 2013 | Option Exercise | $2.00 | 9,418 | 18,845 | 49,602 | May 17, 2013, 07:57 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | May 15, 2013 | Sale | $14.08 | 15,668 | 220,637 | 43,750 | May 17, 2013, 07:57 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | May 15, 2013 | Option Exercise | $2.00 | 799 | 1,598 | 799 | May 17, 2013, 07:56 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | May 15, 2013 | Sale | $14.38 | 799 | 11,486 | 0 | May 17, 2013, 07:56 PM |
| LUCAS ROGER C | Director | May 15, 2013 | Sale | $14.11 | 5,000 | 70,569 | 55,000 | May 17, 2013, 07:54 PM |
| Schall Thomas J. | President and CEO | May 15, 2013 | Sale | $14.04 | 7,600 | 106,728 | 2,171,087 | May 17, 2013, 07:52 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Apr 11, 2013 | Option Exercise | $0.60 | 1,500 | 900 | 45,250 | Apr 12, 2013, 07:45 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Apr 11, 2013 | Sale | $14.10 | 1,500 | 21,150 | 43,750 | Apr 12, 2013, 07:45 PM |
| Bekker Petrus | SVP of Medical & Clinical | Apr 11, 2013 | Option Exercise | $6.00 | 3,979 | 23,874 | 57,573 | Apr 12, 2013, 07:44 PM |
| Bekker Petrus | SVP of Medical & Clinical | Apr 11, 2013 | Sale | $14.03 | 3,979 | 55,829 | 53,594 | Apr 12, 2013, 07:44 PM |
| Schall Thomas J. | President and CEO | Apr 11, 2013 | Sale | $14.02 | 2,312 | 32,409 | 2,178,687 | Apr 12, 2013, 07:43 PM |
| Schall Thomas J. | President and CEO | Apr 10, 2013 | Sale | $14.00 | 217 | 3,038 | 2,180,999 | Apr 12, 2013, 07:43 PM |
| LUCAS ROGER C | Director | Apr 03, 2013 | Sale | $13.49 | 5,000 | 67,468 | 60,000 | Apr 05, 2013, 07:48 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Apr 03, 2013 | Sale | $13.47 | 6,250 | 84,175 | 43,750 | Apr 05, 2013, 07:45 PM |
| Bekker Petrus | SVP of Medical & Clinical | Apr 02, 2013 | Option Exercise | $6.00 | 64 | 384 | 53,658 | Apr 02, 2013, 08:03 PM |
| Bekker Petrus | SVP of Medical & Clinical | Apr 01, 2013 | Option Exercise | $6.00 | 957 | 5,742 | 54,551 | Apr 02, 2013, 08:03 PM |
| Bekker Petrus | SVP of Medical & Clinical | Apr 02, 2013 | Sale | $14.00 | 64 | 896 | 53,594 | Apr 02, 2013, 08:03 PM |
| Bekker Petrus | SVP of Medical & Clinical | Apr 01, 2013 | Sale | $14.00 | 957 | 13,398 | 53,594 | Apr 02, 2013, 08:03 PM |
| Schall Thomas J. | President and CEO | Apr 02, 2013 | Sale | $14.00 | 200 | 2,800 | 2,181,216 | Apr 02, 2013, 08:02 PM |
| Schall Thomas J. | President and CEO | Apr 01, 2013 | Sale | $14.00 | 556 | 7,784 | 2,181,416 | Apr 02, 2013, 08:02 PM |
| Schall Thomas J. | President and CEO | Mar 18, 2013 | Sale | $13.75 | 75 | 1,031 | 2,181,972 | Mar 19, 2013, 07:31 PM |
| Schall Thomas J. | President and CEO | Mar 15, 2013 | Sale | $14.10 | 16,726 | 235,792 | 2,191,473 | Mar 19, 2013, 07:31 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Mar 15, 2013 | Option Exercise | $2.00 | 1,989 | 3,978 | 1,989 | Mar 19, 2013, 07:30 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Mar 15, 2013 | Sale | $14.27 | 1,989 | 28,383 | 0 | Mar 19, 2013, 07:30 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 15, 2013 | Option Exercise | $0.60 | 3,276 | 1,966 | 53,276 | Mar 19, 2013, 07:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 19, 2013 | Option Exercise | $4.30 | 1,783 | 7,667 | 51,783 | Mar 19, 2013, 07:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 15, 2013 | Sale | $14.21 | 3,276 | 46,568 | 50,000 | Mar 19, 2013, 07:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 19, 2013 | Sale | $13.51 | 1,783 | 24,080 | 50,000 | Mar 19, 2013, 07:29 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 18, 2013 | Option Exercise | $3.30 | 5,000 | 16,500 | 58,594 | Mar 19, 2013, 07:28 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 15, 2013 | Option Exercise | $6.00 | 8,889 | 53,334 | 55,697 | Mar 19, 2013, 07:28 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 18, 2013 | Sale | $13.61 | 5,000 | 68,056 | 53,594 | Mar 19, 2013, 07:28 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 15, 2013 | Sale | $14.06 | 8,889 | 124,953 | 53,594 | Mar 19, 2013, 07:28 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 14, 2013 | Option Exercise | $6.00 | 900 | 5,400 | 54,494 | Mar 14, 2013, 08:32 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 13, 2013 | Option Exercise | $6.00 | 3,212 | 19,272 | 56,806 | Mar 14, 2013, 08:32 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 12, 2013 | Option Exercise | $6.00 | 4,276 | 25,656 | 57,870 | Mar 14, 2013, 08:32 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 14, 2013 | Sale | $14.00 | 900 | 12,600 | 53,594 | Mar 14, 2013, 08:32 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 13, 2013 | Sale | $14.00 | 3,212 | 44,968 | 53,594 | Mar 14, 2013, 08:32 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 12, 2013 | Sale | $14.00 | 4,276 | 59,864 | 53,594 | Mar 14, 2013, 08:32 PM |
| Schall Thomas J. | President and CEO | Mar 13, 2013 | Sale | $14.00 | 1,980 | 27,720 | 2,199,195 | Mar 14, 2013, 07:29 PM |
| Schall Thomas J. | President and CEO | Mar 12, 2013 | Sale | $14.00 | 2,503 | 35,042 | 2,201,175 | Mar 14, 2013, 07:29 PM |
| Schall Thomas J. | President and CEO | Mar 14, 2013 | Sale | $14.00 | 422 | 5,908 | 2,198,773 | Mar 14, 2013, 07:29 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 11, 2013 | Option Exercise | $0.60 | 400 | 240 | 50,400 | Mar 13, 2013, 06:57 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Mar 11, 2013 | Sale | $14.15 | 400 | 5,662 | 50,000 | Mar 13, 2013, 06:57 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 08, 2013 | Option Exercise | $6.00 | 4,748 | 28,488 | 58,342 | Mar 11, 2013, 07:06 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 07, 2013 | Option Exercise | $0.60 | 18,498 | 11,099 | 72,092 | Mar 11, 2013, 07:06 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 11, 2013 | Option Exercise | $6.00 | 7,975 | 47,850 | 56,194 | Mar 11, 2013, 07:06 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 08, 2013 | Sale | $14.00 | 4,748 | 66,472 | 53,594 | Mar 11, 2013, 07:06 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 07, 2013 | Sale | $13.83 | 18,498 | 255,761 | 53,594 | Mar 11, 2013, 07:06 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 11, 2013 | Sale | $14.01 | 7,975 | 111,694 | 53,594 | Mar 11, 2013, 07:06 PM |
| Schall Thomas J. | President and CEO | Mar 11, 2013 | Sale | $14.00 | 3,873 | 54,235 | 2,205,978 | Mar 11, 2013, 07:04 PM |
| Schall Thomas J. | President and CEO | Mar 08, 2013 | Sale | $14.00 | 3,075 | 43,050 | 2,207,551 | Mar 11, 2013, 07:04 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Mar 07, 2013 | Sale | $13.95 | 700 | 9,765 | 32,095 | Mar 11, 2013, 06:10 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Mar 08, 2013 | Sale | $13.98 | 2,095 | 29,284 | 30,000 | Mar 11, 2013, 06:10 PM |
| Schall Thomas J. | President and CEO | Mar 06, 2013 | Sale | $14.00 | 1,154 | 16,156 | 2,210,626 | Mar 06, 2013, 07:46 PM |
| Schall Thomas J. | President and CEO | Mar 05, 2013 | Sale | $14.05 | 1,323 | 18,593 | 2,212,703 | Mar 06, 2013, 07:46 PM |
| Schall Thomas J. | President and CEO | Mar 04, 2013 | Sale | $14.00 | 3,064 | 42,896 | 2,213,103 | Mar 06, 2013, 07:46 PM |
| LUCAS ROGER C | Director | Mar 04, 2013 | Sale | $13.87 | 5,000 | 69,327 | 65,000 | Mar 06, 2013, 07:43 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Mar 05, 2013 | Sale | $13.97 | 2,950 | 41,209 | 37,042 | Mar 06, 2013, 07:41 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Mar 04, 2013 | Sale | $13.96 | 5,008 | 69,935 | 39,992 | Mar 06, 2013, 07:41 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Mar 06, 2013 | Sale | $13.97 | 4,247 | 59,329 | 32,795 | Mar 06, 2013, 07:41 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 04, 2013 | Option Exercise | $0.60 | 4,560 | 2,736 | 58,154 | Mar 06, 2013, 07:37 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 06, 2013 | Option Exercise | $0.60 | 5,200 | 3,120 | 58,794 | Mar 06, 2013, 07:37 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 05, 2013 | Option Exercise | $0.60 | 1,742 | 1,045 | 53,994 | Mar 06, 2013, 07:37 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 04, 2013 | Sale | $14.00 | 4,560 | 63,840 | 53,594 | Mar 06, 2013, 07:37 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 06, 2013 | Sale | $13.93 | 5,200 | 72,458 | 53,594 | Mar 06, 2013, 07:37 PM |
| Bekker Petrus | SVP of Medical & Clinical | Mar 05, 2013 | Sale | $14.03 | 1,742 | 24,447 | 53,594 | Mar 06, 2013, 07:37 PM |
| Schall Thomas J. | President and CEO | Mar 01, 2013 | Sale | $13.78 | 5,982 | 82,421 | 2,216,167 | Mar 01, 2013, 07:49 PM |
| Schall Thomas J. | President and CEO | Feb 28, 2013 | Sale | $13.50 | 9,018 | 121,743 | 2,222,149 | Mar 01, 2013, 07:49 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 28, 2013 | Option Exercise | $4.30 | 5,099 | 21,926 | 50,000 | Mar 01, 2013, 07:48 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 27, 2013 | Option Exercise | $4.30 | 7,500 | 32,250 | 49,901 | Mar 01, 2013, 07:48 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 28, 2013 | Sale | $13.12 | 5,099 | 66,920 | 45,000 | Mar 01, 2013, 07:48 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 27, 2013 | Sale | $12.56 | 7,500 | 94,179 | 45,000 | Mar 01, 2013, 07:48 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 28, 2013 | Sale | $13.22 | 25,000 | 330,509 | 68,750 | Mar 01, 2013, 07:47 PM |
| Bekker Petrus | SVP of Medical & Clinical | Feb 22, 2013 | Option Exercise | $0.60 | 15,000 | 9,000 | 58,594 | Feb 26, 2013, 06:45 PM |
| Bekker Petrus | SVP of Medical & Clinical | Feb 22, 2013 | Sale | $12.07 | 15,000 | 181,102 | 53,594 | Feb 26, 2013, 06:45 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Feb 22, 2013 | Option Exercise | $2.00 | 666 | 1,332 | 441 | Feb 26, 2013, 06:43 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Feb 22, 2013 | Sale | $11.91 | 666 | 7,934 | 0 | Feb 26, 2013, 06:43 PM |
| Schall Thomas J. | President and CEO | Feb 22, 2013 | Sale | $12.06 | 7,500 | 90,474 | 2,231,167 | Feb 26, 2013, 06:40 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 25, 2013 | Option Exercise | $4.30 | 7,500 | 32,250 | 52,401 | Feb 26, 2013, 06:38 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 22, 2013 | Option Exercise | $4.30 | 7,500 | 32,250 | 52,401 | Feb 26, 2013, 06:38 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 26, 2013 | Option Exercise | $4.30 | 7,500 | 32,250 | 50,000 | Feb 26, 2013, 06:38 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 22, 2013 | Sale | $12.05 | 7,500 | 90,383 | 45,000 | Feb 26, 2013, 06:38 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 26, 2013 | Sale | $12.37 | 7,500 | 92,756 | 45,000 | Feb 26, 2013, 06:38 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 25, 2013 | Sale | $12.28 | 7,500 | 92,067 | 45,000 | Feb 26, 2013, 06:38 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Feb 20, 2013 | Option Exercise | $2.00 | 6,122 | 12,244 | 3,201 | Feb 21, 2013, 07:34 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Feb 19, 2013 | Option Exercise | $2.00 | 7,725 | 15,450 | 3,929 | Feb 21, 2013, 07:34 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Feb 21, 2013 | Option Exercise | $2.00 | 5,487 | 10,974 | 2,778 | Feb 21, 2013, 07:34 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Feb 20, 2013 | Sale | $11.92 | 6,122 | 72,988 | 0 | Feb 21, 2013, 07:34 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Feb 19, 2013 | Sale | $11.92 | 7,725 | 92,075 | 0 | Feb 21, 2013, 07:34 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Feb 21, 2013 | Sale | $11.89 | 5,487 | 65,248 | 0 | Feb 21, 2013, 07:34 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 20, 2013 | Option Exercise | $4.30 | 5,601 | 24,084 | 50,601 | Feb 21, 2013, 07:32 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 19, 2013 | Option Exercise | $4.30 | 7,500 | 32,250 | 59,800 | Feb 21, 2013, 07:32 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 21, 2013 | Option Exercise | $4.30 | 1,100 | 4,730 | 46,100 | Feb 21, 2013, 07:32 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 20, 2013 | Sale | $11.90 | 5,601 | 66,633 | 45,000 | Feb 21, 2013, 07:32 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 19, 2013 | Sale | $11.91 | 15,500 | 184,535 | 53,000 | Feb 21, 2013, 07:32 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 21, 2013 | Sale | $11.89 | 1,100 | 13,079 | 45,000 | Feb 21, 2013, 07:32 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 15, 2013 | Option Exercise | $4.30 | 1,945 | 8,364 | 54,245 | Feb 19, 2013, 08:02 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 15, 2013 | Sale | $11.74 | 1,945 | 22,825 | 53,000 | Feb 19, 2013, 08:02 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 13, 2013 | Option Exercise | $1.81 | 5,459 | 9,873 | 78,676 | Feb 14, 2013, 07:51 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Feb 13, 2013 | Sale | $11.45 | 5,459 | 62,496 | 75,000 | Feb 14, 2013, 07:51 PM |
| LUCAS ROGER C | Director | Feb 07, 2013 | Sale | $11.27 | 1,143 | 12,884 | 70,000 | Feb 08, 2013, 06:58 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 07, 2013 | Option Exercise | $4.30 | 1,555 | 6,687 | 54,555 | Feb 08, 2013, 06:57 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 07, 2013 | Sale | $11.65 | 1,555 | 18,116 | 53,000 | Feb 08, 2013, 06:57 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 04, 2013 | Option Exercise | $4.30 | 3,875 | 16,663 | 56,100 | Feb 06, 2013, 07:29 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 04, 2013 | Sale | $11.69 | 3,875 | 45,294 | 53,000 | Feb 06, 2013, 07:29 PM |
| LUCAS ROGER C | Director | Feb 06, 2013 | Sale | $11.29 | 757 | 8,548 | 71,143 | Feb 06, 2013, 07:28 PM |
| LUCAS ROGER C | Director | Feb 05, 2013 | Sale | $11.34 | 800 | 9,069 | 71,900 | Feb 06, 2013, 07:28 PM |
| LUCAS ROGER C | Director | Feb 04, 2013 | Sale | $11.66 | 2,300 | 26,809 | 72,700 | Feb 06, 2013, 07:28 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 31, 2013 | Option Exercise | $4.30 | 3,280 | 14,104 | 54,680 | Feb 01, 2013, 07:41 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 01, 2013 | Option Exercise | $4.30 | 6,725 | 28,918 | 58,125 | Feb 01, 2013, 07:41 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Feb 01, 2013 | Sale | $11.61 | 6,725 | 78,106 | 53,000 | Feb 01, 2013, 07:41 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 31, 2013 | Sale | $11.51 | 3,280 | 37,752 | 53,000 | Feb 01, 2013, 07:41 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 29, 2013 | Option Exercise | $4.30 | 4,892 | 21,036 | 57,892 | Jan 29, 2013, 07:24 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 28, 2013 | Option Exercise | $4.30 | 2,710 | 11,653 | 54,782 | Jan 29, 2013, 07:24 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 25, 2013 | Option Exercise | $4.30 | 96 | 413 | 53,096 | Jan 29, 2013, 07:24 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 29, 2013 | Sale | $11.45 | 4,892 | 56,013 | 53,000 | Jan 29, 2013, 07:24 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 28, 2013 | Sale | $11.38 | 2,710 | 30,851 | 53,000 | Jan 29, 2013, 07:24 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 25, 2013 | Sale | $11.35 | 96 | 1,090 | 53,000 | Jan 29, 2013, 07:24 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 24, 2013 | Option Exercise | $4.30 | 1,200 | 5,160 | 54,200 | Jan 24, 2013, 07:21 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 22, 2013 | Option Exercise | $4.30 | 100 | 430 | 53,100 | Jan 24, 2013, 07:21 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 24, 2013 | Sale | $11.35 | 1,200 | 13,622 | 53,000 | Jan 24, 2013, 07:21 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 22, 2013 | Sale | $11.35 | 100 | 1,135 | 53,000 | Jan 24, 2013, 07:21 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 18, 2013 | Option Exercise | $0.60 | 2,759 | 1,655 | 77,759 | Jan 22, 2013, 06:07 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 18, 2013 | Sale | $11.16 | 2,759 | 30,799 | 75,000 | Jan 22, 2013, 06:07 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 17, 2013 | Option Exercise | $1.69 | 1,300 | 2,197 | 75,917 | Jan 17, 2013, 07:59 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 16, 2013 | Option Exercise | $4.30 | 600 | 2,580 | 75,600 | Jan 17, 2013, 07:59 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 15, 2013 | Option Exercise | $4.30 | 800 | 3,440 | 75,800 | Jan 17, 2013, 07:59 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 17, 2013 | Sale | $11.15 | 1,300 | 14,501 | 75,000 | Jan 17, 2013, 07:59 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 16, 2013 | Sale | $11.18 | 600 | 6,705 | 75,000 | Jan 17, 2013, 07:59 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Jan 15, 2013 | Sale | $11.15 | 800 | 8,920 | 75,000 | Jan 17, 2013, 07:59 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 12, 2013 | Option Exercise | $4.30 | 3,305 | 14,212 | 56,305 | Jan 15, 2013, 08:27 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 12, 2013 | Sale | $11.35 | 3,305 | 37,512 | 53,000 | Jan 15, 2013, 08:27 PM |
| LUCAS ROGER C | Director | Jan 08, 2013 | Sale | $11.00 | 2,099 | 23,098 | 75,000 | Jan 09, 2013, 08:24 PM |
| LUCAS ROGER C | Director | Jan 07, 2013 | Sale | $11.16 | 1,800 | 20,094 | 77,099 | Jan 09, 2013, 08:24 PM |
| LUCAS ROGER C | Director | Jan 04, 2013 | Sale | $11.08 | 700 | 7,759 | 78,899 | Jan 04, 2013, 07:04 PM |
| LUCAS ROGER C | Director | Jan 03, 2013 | Sale | $11.10 | 401 | 4,453 | 79,599 | Jan 04, 2013, 07:04 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 04, 2013 | Option Exercise | $4.30 | 96 | 413 | 53,096 | Jan 04, 2013, 06:59 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 03, 2013 | Option Exercise | $4.30 | 100 | 430 | 53,100 | Jan 04, 2013, 06:59 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 02, 2013 | Option Exercise | $4.30 | 5,821 | 25,030 | 58,000 | Jan 04, 2013, 06:59 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 03, 2013 | Sale | $11.35 | 100 | 1,135 | 53,000 | Jan 04, 2013, 06:59 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 02, 2013 | Sale | $11.26 | 5,821 | 65,568 | 53,000 | Jan 04, 2013, 06:59 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Jan 04, 2013 | Sale | $11.35 | 96 | 1,090 | 53,000 | Jan 04, 2013, 06:59 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Dec 18, 2012 | Option Exercise | $1.96 | 4,843 | 9,503 | 78,060 | Dec 20, 2012, 08:03 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Dec 18, 2012 | Sale | $10.94 | 4,843 | 52,984 | 75,000 | Dec 20, 2012, 08:03 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Dec 18, 2012 | Option Exercise | $4.30 | 7,500 | 32,250 | 58,000 | Dec 19, 2012, 07:11 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Dec 17, 2012 | Option Exercise | $4.30 | 7,500 | 32,250 | 58,000 | Dec 19, 2012, 07:11 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Dec 18, 2012 | Sale | $11.12 | 7,500 | 83,375 | 53,000 | Dec 19, 2012, 07:11 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Dec 17, 2012 | Sale | $10.98 | 7,500 | 82,375 | 53,000 | Dec 19, 2012, 07:11 PM |
| LUCAS ROGER C | Director | Dec 04, 2012 | Sale | $11.97 | 4,800 | 57,443 | 80,000 | Dec 04, 2012, 08:27 PM |
| LUCAS ROGER C | Director | Dec 03, 2012 | Sale | $11.72 | 200 | 2,344 | 84,800 | Dec 04, 2012, 08:27 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Dec 04, 2012 | Option Exercise | $2.00 | 4,693 | 9,386 | 4,693 | Dec 04, 2012, 08:25 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Dec 03, 2012 | Option Exercise | $2.00 | 404 | 808 | 404 | Dec 04, 2012, 08:25 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Nov 30, 2012 | Option Exercise | $2.00 | 830 | 1,660 | 830 | Dec 04, 2012, 08:25 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Dec 04, 2012 | Sale | $11.98 | 4,693 | 56,217 | 0 | Dec 04, 2012, 08:25 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Dec 03, 2012 | Sale | $11.93 | 404 | 4,818 | 0 | Dec 04, 2012, 08:25 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Nov 30, 2012 | Sale | $11.94 | 830 | 9,910 | 0 | Dec 04, 2012, 08:25 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Nov 29, 2012 | Option Exercise | $2.00 | 3,839 | 7,678 | 3,839 | Nov 30, 2012, 07:36 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Nov 28, 2012 | Option Exercise | $2.00 | 234 | 468 | 234 | Nov 30, 2012, 07:36 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Nov 29, 2012 | Sale | $11.89 | 3,839 | 45,663 | 0 | Nov 30, 2012, 07:36 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Nov 28, 2012 | Sale | $11.90 | 234 | 2,784 | 0 | Nov 30, 2012, 07:36 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 26, 2012 | Option Exercise | $0.60 | 201 | 121 | 75,201 | Nov 28, 2012, 06:18 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 26, 2012 | Sale | $12.10 | 201 | 2,432 | 75,000 | Nov 28, 2012, 06:18 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 23, 2012 | Option Exercise | $2.42 | 795 | 1,920 | 75,405 | Nov 26, 2012, 12:48 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 21, 2012 | Option Exercise | $4.30 | 1,393 | 5,990 | 76,393 | Nov 26, 2012, 12:48 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 21, 2012 | Sale | $11.90 | 1,393 | 16,578 | 75,000 | Nov 26, 2012, 12:48 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 23, 2012 | Sale | $12.02 | 795 | 9,558 | 75,000 | Nov 26, 2012, 12:48 PM |
| Schall Thomas J. | President and CEO | Nov 20, 2012 | Sale | $12.01 | 999 | 11,997 | 2,238,667 | Nov 21, 2012, 03:33 PM |
| Schall Thomas J. | President and CEO | Nov 19, 2012 | Sale | $12.02 | 1,101 | 13,232 | 2,239,666 | Nov 21, 2012, 03:33 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 20, 2012 | Option Exercise | $0.60 | 3 | 2 | 75,003 | Nov 21, 2012, 03:31 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 19, 2012 | Option Exercise | $0.60 | 7 | 4 | 75,007 | Nov 21, 2012, 03:31 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 19, 2012 | Sale | $12.10 | 7 | 85 | 75,000 | Nov 21, 2012, 03:31 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 20, 2012 | Sale | $12.10 | 3 | 36 | 75,000 | Nov 21, 2012, 03:31 PM |
| Bekker Petrus | SVP of Medical & Clinical | Nov 20, 2012 | Option Exercise | $0.60 | 3,439 | 2,063 | 57,033 | Nov 20, 2012, 06:09 PM |
| Bekker Petrus | SVP of Medical & Clinical | Nov 19, 2012 | Option Exercise | $0.60 | 1,561 | 937 | 55,155 | Nov 20, 2012, 06:09 PM |
| Bekker Petrus | SVP of Medical & Clinical | Nov 16, 2012 | Sale | $11.90 | 10,000 | 119,000 | 53,594 | Nov 20, 2012, 06:09 PM |
| Bekker Petrus | SVP of Medical & Clinical | Nov 20, 2012 | Sale | $12.01 | 3,439 | 41,313 | 53,594 | Nov 20, 2012, 06:09 PM |
| Bekker Petrus | SVP of Medical & Clinical | Nov 19, 2012 | Sale | $12.01 | 1,561 | 18,749 | 53,594 | Nov 20, 2012, 06:09 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 06, 2012 | Buy | $12.00 | 40,000 | 479,828 | 3,750,277 | Nov 19, 2012, 05:22 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Nov 14, 2012 | Sale | $12.95 | 2,000 | 25,900 | 53,000 | Nov 16, 2012, 07:29 PM |
| Schall Thomas J. | President and CEO | Nov 16, 2012 | Sale | $12.00 | 2,000 | 24,000 | 2,240,767 | Nov 16, 2012, 07:24 PM |
| Schall Thomas J. | President and CEO | Nov 15, 2012 | Sale | $12.18 | 3,400 | 41,423 | 2,242,767 | Nov 16, 2012, 07:24 PM |
| Schall Thomas J. | President and CEO | Nov 14, 2012 | Sale | $12.75 | 15,000 | 191,250 | 2,246,167 | Nov 16, 2012, 07:24 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Nov 06, 2012 | Sale | $12.01 | 5,833 | 70,030 | 55,000 | Nov 08, 2012, 07:41 PM |
| Bekker Petrus | SVP of Medical & Clinical | Nov 06, 2012 | Option Exercise | $0.60 | 9,300 | 5,580 | 71,800 | Nov 08, 2012, 07:40 PM |
| Bekker Petrus | SVP of Medical & Clinical | Nov 06, 2012 | Sale | $12.01 | 9,300 | 111,697 | 67,500 | Nov 08, 2012, 07:40 PM |
| Schall Thomas J. | President and CEO | Nov 06, 2012 | Sale | $12.01 | 22,500 | 270,161 | 2,294,167 | Nov 08, 2012, 07:39 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 06, 2012 | Option Exercise | $0.60 | 3,676 | 2,206 | 78,676 | Nov 08, 2012, 07:38 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Nov 06, 2012 | Sale | $12.10 | 3,676 | 44,480 | 75,000 | Nov 08, 2012, 07:38 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Nov 06, 2012 | Option Exercise | $2.00 | 16,029 | 32,058 | 16,029 | Nov 08, 2012, 07:38 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Nov 06, 2012 | Sale | $11.91 | 16,029 | 190,909 | 10,000 | Nov 08, 2012, 07:38 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 06, 2012 | Buy | $12.00 | 40,000 | 479,828 | 3,750,277 | Nov 08, 2012, 06:13 PM |
| LUCAS ROGER C | Director | Nov 06, 2012 | Sale | $11.83 | 2,500 | 29,572 | 85,000 | Nov 07, 2012, 05:32 PM |
| LUCAS ROGER C | Director | Nov 05, 2012 | Sale | $11.34 | 2,500 | 28,357 | 87,500 | Nov 07, 2012, 05:32 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Oct 19, 2012 | Option Exercise | $0.60 | 2,900 | 1,740 | 77,900 | Oct 22, 2012, 06:34 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Oct 18, 2012 | Option Exercise | $2.31 | 7,702 | 17,815 | 82,702 | Oct 22, 2012, 06:34 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Oct 22, 2012 | Option Exercise | $0.60 | 316 | 190 | 75,316 | Oct 22, 2012, 06:34 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Oct 19, 2012 | Sale | $11.00 | 2,900 | 31,914 | 75,000 | Oct 22, 2012, 06:34 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Oct 18, 2012 | Sale | $10.83 | 7,702 | 83,410 | 75,000 | Oct 22, 2012, 06:34 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Oct 22, 2012 | Sale | $10.70 | 316 | 3,380 | 75,000 | Oct 22, 2012, 06:34 PM |
| LUCAS ROGER C | Director | Oct 04, 2012 | Sale | $11.47 | 1,893 | 21,711 | 90,000 | Oct 09, 2012, 04:42 PM |
| LUCAS ROGER C | Director | Oct 03, 2012 | Sale | $11.38 | 3,107 | 35,372 | 91,893 | Oct 03, 2012, 07:19 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Oct 01, 2012 | Option Exercise | $2.00 | 3,971 | 7,942 | 3,971 | Oct 03, 2012, 07:10 PM |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | Oct 01, 2012 | Sale | $11.89 | 3,971 | 47,216 | 0 | Oct 03, 2012, 07:10 PM |
| Schall Thomas J. | President and CEO | Oct 01, 2012 | Sale | $11.53 | 15,000 | 172,955 | 2,301,667 | Oct 03, 2012, 07:08 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Sep 27, 2012 | Sale | $11.95 | 300 | 3,586 | 62,933 | Oct 01, 2012, 06:52 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Oct 01, 2012 | Sale | $11.98 | 2,100 | 25,157 | 60,833 | Oct 01, 2012, 06:52 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Sep 25, 2012 | Option Exercise | $1.81 | 5,459 | 9,873 | 80,459 | Sep 27, 2012, 03:00 PM |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | Sep 25, 2012 | Sale | $11.86 | 5,459 | 64,725 | 75,000 | Sep 27, 2012, 03:00 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Sep 25, 2012 | Sale | $11.96 | 7,401 | 88,480 | 63,233 | Sep 27, 2012, 02:58 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Sep 24, 2012 | Sale | $11.96 | 2,705 | 32,358 | 70,634 | Sep 24, 2012, 07:49 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Sep 21, 2012 | Sale | $12.01 | 200 | 2,402 | 73,339 | Sep 24, 2012, 07:49 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Sep 20, 2012 | Sale | $12.01 | 661 | 7,937 | 73,539 | Sep 24, 2012, 07:49 PM |
| Bekker Petrus | SVP of Medical & Clinical | Sep 20, 2012 | Option Exercise | $0.60 | 200 | 120 | 62,700 | Sep 24, 2012, 06:50 PM |
| Bekker Petrus | SVP of Medical & Clinical | Sep 24, 2012 | Option Exercise | $0.60 | 100 | 60 | 62,600 | Sep 24, 2012, 06:50 PM |
| Bekker Petrus | SVP of Medical & Clinical | Sep 24, 2012 | Sale | $12.01 | 100 | 1,201 | 62,500 | Sep 24, 2012, 06:50 PM |
| Bekker Petrus | SVP of Medical & Clinical | Sep 20, 2012 | Sale | $12.02 | 200 | 2,404 | 62,500 | Sep 24, 2012, 06:50 PM |
| Jaen Juan C. | SVP, Drug Discovery & CSO | Sep 17, 2012 | Sale | $12.05 | 800 | 9,638 | 74,200 | Sep 19, 2012, 07:23 PM |
| Bekker Petrus | SVP of Medical & Clinical | Sep 17, 2012 | Option Exercise | $0.60 | 400 | 240 | 62,900 | Sep 19, 2012, 07:22 PM |
| Bekker Petrus | SVP of Medical & Clinical | Sep 17, 2012 | Sale | $12.12 | 400 | 4,849 | 62,500 | Sep 19, 2012, 07:22 PM |
| LUCAS ROGER C | Director | Sep 18, 2012 | Sale | $11.71 | 1,200 | 14,054 | 95,000 | Sep 19, 2012, 02:59 PM |
| LUCAS ROGER C | Director | Sep 17, 2012 | Sale | $11.92 | 3,800 | 45,286 | 96,200 | Sep 19, 2012, 02:59 PM |
| TECHNE CORP /MN/ | 10% Owner | Feb 13, 2012 | Buy | $10.00 | 500,000 | 5,000,000 | 6,235,056 | Feb 14, 2012, 02:26 PM |
| Parker Geoffrey M. | Director | Feb 10, 2012 | Buy | $10.97 | 4,600 | 50,462 | 4,600 | Feb 13, 2012, 09:31 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| KANAYA SUSAN M | EVP, CFO and Sec. | 08/16/2022 | 216,092 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 08/16/2022 | 1,013,793 |
| Schall Thomas J. | President and CEO | 08/04/2022 | 1,856,400 |
| Schall Thomas J. | President and CEO | 08/04/2022 | 6,531,733 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 08/04/2022 | 300,805 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 08/04/2022 | 2,322,715 |
| Tyree James L | Director | 08/04/2022 | 502,200 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 08/04/2022 | 379,864 |
| Tyree James L | Director | 06/09/2022 | 99,129 |
| Parker Geoffrey M. | Director | 05/02/2022 | 180,250 |
| FECZKO JOSEPH M | Director | 01/21/2022 | 577,750 |
| Schall Thomas J. | President and CEO | 01/01/2022 | 1,663,864 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/01/2022 | 613,399 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/01/2022 | 420,099 |
| Tyree James L | Director | 12/17/2021 | 495,750 |
| Tyree James L | Director | 12/17/2021 | 1,313,165 |
| Schall Thomas J. | President and CEO | 12/01/2021 | 499,994 |
| Vifor (International) Ltd | 10% Owner | 10/12/2021 | 157,720,001 |
| Tyree James L | Director | 05/21/2021 | 23,956 |
| Parker Geoffrey M. | Director | 03/05/2021 | 1,691,468 |
| Parker Geoffrey M. | Director | 03/04/2021 | 114,980 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/01/2021 | 338,972 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/01/2021 | 2,264,443 |
| Edwards Thomas A. | Director | 03/02/2021 | 77,063 |
| Kwan Pui San | Principal Acctg Officer | 03/01/2021 | 35,012 |
| Kwan Pui San | Principal Acctg Officer | 03/01/2021 | 229,335 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/09/2021 | 7,714 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/09/2021 | 48,765 |
| Edwards Thomas A. | Director | 02/09/2021 | 28,014 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/08/2021 | 81,768 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/05/2021 | 8,871 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/04/2021 | 15,428 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/08/2021 | 499,351 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/05/2021 | 53,994 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/04/2021 | 93,995 |
| Kwan Pui San | Principal Acctg Officer | 02/04/2021 | 35,012 |
| Kwan Pui San | Principal Acctg Officer | 02/04/2021 | 217,555 |
| Edwards Thomas A. | Director | 02/02/2021 | 1,218,844 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/25/2021 | 15,153 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/25/2021 | 92,172 |
| Kwan Pui San | Principal Acctg Officer | 01/25/2021 | 40,564 |
| Kwan Pui San | Principal Acctg Officer | 01/25/2021 | 271,960 |
| Schall Thomas J. | President and CEO | 01/01/2021 | 2,945,906 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/01/2021 | 1,021,556 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/01/2021 | 713,380 |
| Edwards Thomas A. | Director | 12/28/2020 | 663,093 |
| Edwards Thomas A. | Director | 12/24/2020 | 869,904 |
| Schall Thomas J. | President and CEO | 12/14/2020 | 159,599 |
| Schall Thomas J. | President and CEO | 12/15/2020 | 252,128 |
| Schall Thomas J. | President and CEO | 12/14/2020 | 725,246 |
| Schall Thomas J. | President and CEO | 12/15/2020 | 1,145,450 |
| Kwan Pui San | Principal Acctg Officer | 12/15/2020 | 428,943 |
| Kwan Pui San | Principal Acctg Officer | 12/14/2020 | 63,158 |
| Kwan Pui San | Principal Acctg Officer | 12/15/2020 | 2,771,237 |
| Kwan Pui San | Principal Acctg Officer | 12/14/2020 | 582,398 |
| Vifor (International) Ltd | 10% Owner | 07/31/2020 | 2,116,824 |
| Vifor (International) Ltd | 10% Owner | 07/30/2020 | 2,625,330 |
| Vifor (International) Ltd | 10% Owner | 08/03/2020 | 2,656,655 |
| Vifor (International) Ltd | 10% Owner | 07/29/2020 | 4,627,479 |
| Vifor (International) Ltd | 10% Owner | 07/28/2020 | 2,149,117 |
| Vifor (International) Ltd | 10% Owner | 07/27/2020 | 1,825,476 |
| Vifor (International) Ltd | 10% Owner | 07/23/2020 | 1,871,297 |
| Vifor (International) Ltd | 10% Owner | 07/22/2020 | 4,027,868 |
| Vifor (International) Ltd | 10% Owner | 07/24/2020 | 1,368,737 |
| Vifor (International) Ltd | 10% Owner | 07/21/2020 | 4,857,632 |
| Vifor (International) Ltd | 10% Owner | 07/20/2020 | 3,059,053 |
| Vifor (International) Ltd | 10% Owner | 07/17/2020 | 2,675,105 |
| Vifor (International) Ltd | 10% Owner | 07/15/2020 | 5,110,971 |
| Vifor (International) Ltd | 10% Owner | 07/14/2020 | 5,808,318 |
| Vifor (International) Ltd | 10% Owner | 07/16/2020 | 4,186,741 |
| Vifor (International) Ltd | 10% Owner | 07/13/2020 | 5,815,027 |
| Vifor (International) Ltd | 10% Owner | 07/10/2020 | 2,747,172 |
| Vifor (International) Ltd | 10% Owner | 07/09/2020 | 5,990,521 |
| Vifor (International) Ltd | 10% Owner | 07/06/2020 | 5,066,120 |
| Vifor (International) Ltd | 10% Owner | 07/08/2020 | 5,994,745 |
| Vifor (International) Ltd | 10% Owner | 07/07/2020 | 4,700,838 |
| Vifor (International) Ltd | 10% Owner | 07/02/2020 | 5,044,434 |
| Schall Thomas J. | President and CEO | 06/15/2020 | 28,620 |
| Schall Thomas J. | President and CEO | 06/12/2020 | 1,270,055 |
| Schall Thomas J. | President and CEO | 06/15/2020 | 130,090 |
| Schall Thomas J. | President and CEO | 06/12/2020 | 5,775,877 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/12/2020 | 466,100 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/12/2020 | 3,229,035 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/12/2020 | 364,255 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/12/2020 | 2,183,519 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/03/2020 | 57,059 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/22/2020 | 270,540 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/21/2020 | 18,536 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/26/2020 | 129,831 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/22/2020 | 2,454,525 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/21/2020 | 167,986 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/26/2020 | 1,183,423 |
| Schall Thomas J. | President and CEO | 05/11/2020 | 1,010,401 |
| Schall Thomas J. | President and CEO | 05/08/2020 | 60,116 |
| Schall Thomas J. | President and CEO | 05/12/2020 | 513,228 |
| Schall Thomas J. | President and CEO | 05/08/2020 | 231,115 |
| Schall Thomas J. | President and CEO | 05/12/2020 | 2,071,100 |
| Schall Thomas J. | President and CEO | 05/11/2020 | 3,919,731 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/08/2020 | 15,394 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/11/2020 | 122,173 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/11/2020 | 1,886,135 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/08/2020 | 215,639 |
| Schall Thomas J. | President and CEO | 05/05/2020 | 126,658 |
| Schall Thomas J. | President and CEO | 05/05/2020 | 486,851 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/05/2020 | 31,630 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/05/2020 | 487,345 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/04/2020 | 449,443 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/05/2020 | 164,807 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/04/2020 | 2,994,819 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/05/2020 | 1,101,237 |
| Parker Geoffrey M. | Director | 03/23/2020 | 1,101,049 |
| Schall Thomas J. | President and CEO | 03/04/2020 | 584,478 |
| Schall Thomas J. | President and CEO | 03/04/2020 | 2,056,691 |
| Schall Thomas J. | President and CEO | 02/20/2020 | 219,530 |
| Schall Thomas J. | President and CEO | 02/19/2020 | 906,395 |
| Schall Thomas J. | President and CEO | 02/19/2020 | 3,198,514 |
| Schall Thomas J. | President and CEO | 02/20/2020 | 770,296 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/19/2020 | 262,812 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/19/2020 | 1,213,221 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/19/2020 | 349,148 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/19/2020 | 2,146,698 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/13/2020 | 442,029 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/12/2020 | 24,213 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/11/2020 | 32,046 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/13/2020 | 2,247,147 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/12/2020 | 123,776 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/11/2020 | 148,510 |
| Kwan Pui San | Principal Acctg Officer | 02/11/2020 | 930,888 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/06/2020 | 301,801 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/06/2020 | 1,743,340 |
| Schall Thomas J. | President and CEO | 02/04/2020 | 1,710,403 |
| Schall Thomas J. | President and CEO | 02/04/2020 | 5,400,701 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/04/2020 | 1,425,519 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/03/2020 | 54,907 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/03/2020 | 172,317 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/04/2020 | 4,492,229 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/05/2020 | 107,698 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/03/2020 | 396,977 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/05/2020 | 618,451 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/03/2020 | 2,155,525 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/21/2020 | 10,311 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/21/2020 | 55,392 |
| Schall Thomas J. | President and CEO | 01/17/2020 | 1,085,898 |
| Schall Thomas J. | President and CEO | 01/16/2020 | 311,356 |
| Schall Thomas J. | President and CEO | 01/17/2020 | 4,398,272 |
| Schall Thomas J. | President and CEO | 01/16/2020 | 1,243,170 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/17/2020 | 224,724 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/16/2020 | 674,887 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/17/2020 | 645,730 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/16/2020 | 1,937,101 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/16/2020 | 355,000 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/16/2020 | 2,003,480 |
| Kwan Pui San | Principal Acctg Officer | 01/16/2020 | 740,881 |
| Kwan Pui San | Principal Acctg Officer | 01/16/2020 | 3,559,216 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/14/2020 | 214,029 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/13/2020 | 612,808 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/14/2020 | 1,138,908 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/13/2020 | 3,201,540 |
| Tyree James L | Director | 01/13/2020 | 1,111,686 |
| Kwan Pui San | Principal Acctg Officer | 01/10/2020 | 3,570 |
| Kwan Pui San | Principal Acctg Officer | 01/10/2020 | 39,016 |
| Kwan Pui San | Principal Acctg Officer | 01/06/2020 | 945,642 |
| Kwan Pui San | Principal Acctg Officer | 01/06/2020 | 4,249,007 |
| Schall Thomas J. | President and CEO | 01/01/2020 | 1,857,466 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/01/2020 | 718,742 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/01/2020 | 505,686 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 12/27/2019 | 769,486 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 12/20/2019 | 184,835 |
| Parker Geoffrey M. | Director | 12/02/2019 | 191,940 |
| Schall Thomas J. | President and CEO | 11/26/2019 | 1,758,746 |
| Schall Thomas J. | President and CEO | 11/26/2019 | 8,808,112 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 11/26/2019 | 2,146,410 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 11/26/2019 | 9,818,230 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/26/2019 | 3,753,261 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/26/2019 | 10,585,167 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 10/20/2019 | 138,600 |
| Parker Geoffrey M. | Director | 05/30/2019 | 108,060 |
| Parker Geoffrey M. | Director | 05/30/2019 | 153,806 |
| SINGH RAJINDER | SVP, Research | 04/15/2019 | 69,300 |
| SINGH RAJINDER | SVP, Research | 04/15/2019 | 427,706 |
| Schall Thomas J. | President and CEO | 03/29/2019 | 34,530 |
| Schall Thomas J. | President and CEO | 04/02/2019 | 449,916 |
| Schall Thomas J. | President and CEO | 04/01/2019 | 475,554 |
| Schall Thomas J. | President and CEO | 04/02/2019 | 1,038,909 |
| Schall Thomas J. | President and CEO | 04/01/2019 | 1,076,084 |
| Schall Thomas J. | President and CEO | 03/29/2019 | 80,570 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 03/27/2019 | 124,950 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 03/27/2019 | 456,827 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 02/25/2019 | 10,842 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/22/2019 | 135,278 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/22/2019 | 457,747 |
| Schall Thomas J. | President and CEO | 01/10/2019 | 220,572 |
| Schall Thomas J. | President and CEO | 01/10/2019 | 447,092 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/10/2019 | 37,032 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/10/2019 | 74,079 |
| Schall Thomas J. | President and CEO | 01/07/2019 | 43,650 |
| Schall Thomas J. | President and CEO | 01/09/2019 | 77,370 |
| Schall Thomas J. | President and CEO | 01/09/2019 | 154,771 |
| Schall Thomas J. | President and CEO | 01/07/2019 | 87,599 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/09/2019 | 48,804 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/07/2019 | 30,414 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/09/2019 | 97,628 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/07/2019 | 61,162 |
| Schall Thomas J. | President and CEO | 01/01/2019 | 576,113 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/01/2019 | 261,927 |
| SINGH RAJINDER | SVP, Research | 01/01/2019 | 95,092 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/01/2019 | 146,030 |
| Schall Thomas J. | President and CEO | 11/07/2018 | 43,266 |
| Schall Thomas J. | President and CEO | 11/07/2018 | 86,554 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 10/26/2018 | 181,422 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 10/26/2018 | 332,779 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 10/20/2018 | 204,695 |
| GLAXOSMITHKLINE PLC | Former 10% holder | 10/16/2018 | 85,845,418 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/29/2018 | 357 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/29/2018 | 1,410 |
| Schall Thomas J. | President and CEO | 06/28/2018 | 64,542 |
| Schall Thomas J. | President and CEO | 06/29/2018 | 600 |
| Schall Thomas J. | President and CEO | 06/28/2018 | 150,618 |
| Schall Thomas J. | President and CEO | 06/29/2018 | 1,410 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/27/2018 | 4,800 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/29/2018 | 600 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/28/2018 | 145,674 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/29/2018 | 1,410 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/28/2018 | 331,991 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/27/2018 | 10,800 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/28/2018 | 280,015 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/27/2018 | 294,900 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/26/2018 | 5,100 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/28/2018 | 682,496 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/27/2018 | 651,238 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 06/26/2018 | 11,263 |
| Schall Thomas J. | President and CEO | 05/23/2018 | 167,568 |
| Schall Thomas J. | President and CEO | 05/22/2018 | 185,592 |
| Schall Thomas J. | President and CEO | 05/21/2018 | 203,628 |
| Schall Thomas J. | President and CEO | 05/23/2018 | 363,293 |
| Schall Thomas J. | President and CEO | 05/22/2018 | 402,150 |
| Schall Thomas J. | President and CEO | 05/21/2018 | 426,022 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/21/2018 | 16,254 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/21/2018 | 35,217 |
| Schall Thomas J. | President and CEO | 05/15/2018 | 600,000 |
| Schall Thomas J. | President and CEO | 05/17/2018 | 106,788 |
| Schall Thomas J. | President and CEO | 05/16/2018 | 493,212 |
| Schall Thomas J. | President and CEO | 05/17/2018 | 216,137 |
| Schall Thomas J. | President and CEO | 05/16/2018 | 1,007,665 |
| Schall Thomas J. | President and CEO | 05/15/2018 | 1,132,060 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/16/2018 | 300,000 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/16/2018 | 590,637 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/15/2018 | 49,836 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/15/2018 | 92,526 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/08/2018 | 391,968 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/08/2018 | 752,925 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/02/2018 | 8,196 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 05/02/2018 | 15,709 |
| Schall Thomas J. | President and CEO | 05/01/2018 | 102,762 |
| Schall Thomas J. | President and CEO | 05/02/2018 | 197,238 |
| Schall Thomas J. | President and CEO | 05/02/2018 | 362,451 |
| Schall Thomas J. | President and CEO | 05/01/2018 | 188,407 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/02/2018 | 228,534 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/01/2018 | 71,466 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/02/2018 | 419,886 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/01/2018 | 131,027 |
| Schall Thomas J. | President and CEO | 01/01/2018 | 218,466 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/01/2018 | 113,342 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/01/2018 | 64,843 |
| SINGH RAJINDER | SVP, Research | 01/01/2018 | 33,736 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 10/20/2017 | 131,876 |
| LUCAS ROGER C | Director | 08/01/2017 | 22,667 |
| Bekker Petrus | Chief Medical Officer | 07/12/2017 | 201,874 |
| Bekker Petrus | Chief Medical Officer | 07/11/2017 | 203,326 |
| Bekker Petrus | Chief Medical Officer | 07/13/2017 | 126,909 |
| Bekker Petrus | Chief Medical Officer | 07/12/2017 | 299,280 |
| Bekker Petrus | Chief Medical Officer | 07/11/2017 | 293,326 |
| Bekker Petrus | Chief Medical Officer | 07/13/2017 | 163,464 |
| Bekker Petrus | Chief Medical Officer | 07/07/2017 | 123,398 |
| Bekker Petrus | Chief Medical Officer | 07/10/2017 | 1,827 |
| Bekker Petrus | Chief Medical Officer | 07/10/2017 | 2,697 |
| Bekker Petrus | Chief Medical Officer | 07/07/2017 | 182,159 |
| Bekker Petrus | Chief Medical Officer | 06/28/2017 | 213,000 |
| Bekker Petrus | Chief Medical Officer | 06/30/2017 | 198,593 |
| Bekker Petrus | Chief Medical Officer | 06/29/2017 | 39,114 |
| Bekker Petrus | Chief Medical Officer | 06/30/2017 | 276,870 |
| Bekker Petrus | Chief Medical Officer | 06/29/2017 | 50,167 |
| Bekker Petrus | Chief Medical Officer | 06/28/2017 | 273,669 |
| LUCAS ROGER C | Director | 05/01/2017 | 29,228 |
| LUCAS ROGER C | Director | 02/01/2017 | 29,290 |
| Bekker Petrus | Chief Medical Officer | 01/01/2017 | 52,451 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/01/2017 | 32,871 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/03/2017 | 115,330 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/03/2017 | 201,305 |
| KANAYA SUSAN M | EVP, CFO and Sec. | 01/01/2017 | 79,350 |
| Schall Thomas J. | President and CEO | 01/01/2017 | 132,867 |
| Bekker Petrus | Chief Medical Officer | 12/16/2016 | 54,112 |
| Bekker Petrus | Chief Medical Officer | 12/16/2016 | 76,120 |
| Bekker Petrus | Chief Medical Officer | 12/05/2016 | 180,000 |
| Bekker Petrus | Chief Medical Officer | 12/05/2016 | 255,000 |
| Bekker Petrus | Chief Medical Officer | 11/22/2016 | 7,875 |
| Bekker Petrus | Chief Medical Officer | 11/22/2016 | 10,375 |
| Bekker Petrus | Chief Medical Officer | 11/09/2016 | 3,804 |
| Bekker Petrus | Chief Medical Officer | 11/11/2016 | 16,188 |
| Bekker Petrus | Chief Medical Officer | 11/10/2016 | 180,000 |
| Bekker Petrus | Chief Medical Officer | 11/11/2016 | 21,584 |
| Bekker Petrus | Chief Medical Officer | 11/10/2016 | 240,000 |
| Bekker Petrus | Chief Medical Officer | 11/09/2016 | 5,072 |
| LUCAS ROGER C | Director | 11/01/2016 | 24,411 |
| LUCAS ROGER C | Director | 09/01/2016 | 20,262 |
| Tyree James L | Director | 05/23/2016 | 24,337 |
| Edwards Thomas A. | Director | 05/17/2016 | 202,500 |
| Edwards Thomas A. | Director | 05/16/2016 | 101,213 |
| Parker Geoffrey M. | Director | 05/13/2016 | 161,388 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/22/2016 | 30,254 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/21/2016 | 21,274 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/22/2016 | 61,429 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/21/2016 | 42,726 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/19/2016 | 12,268 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/15/2016 | 600 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/20/2016 | 29,942 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/19/2016 | 24,826 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/15/2016 | 1,200 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/20/2016 | 61,341 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/08/2016 | 20,448 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/08/2016 | 52,347 |
| Parker Geoffrey M. | Director | 01/11/2016 | 92,512 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/06/2016 | 5,552 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/05/2016 | 68,682 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/04/2016 | 20,980 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/06/2016 | 18,195 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/05/2016 | 236,874 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 01/04/2016 | 77,379 |
| Parker Geoffrey M. | Director | 12/11/2015 | 33,724 |
| Parker Geoffrey M. | Director | 12/10/2015 | 111,202 |
| BVF PARTNERS L P/IL | See Explanation of Responses | 11/03/2015 | 509,343 |
| BVF PARTNERS L P/IL | See Explanation of Responses | 11/04/2015 | 2,009,057 |
| BVF PARTNERS L P/IL | 10% Owner | 11/02/2015 | 348,515 |
| BVF PARTNERS L P/IL | 10% Owner | 06/10/2015 | 279,229 |
| BVF PARTNERS L P/IL | 10% Owner | 06/09/2015 | 8,322,393 |
| Parker Geoffrey M. | Director | 05/27/2015 | 101,515 |
| KLEIN IRA | Director | 05/22/2015 | 80,484 |
| Tyree James L | Director | 05/22/2015 | 94,593 |
| Schall Thomas J. | President and CEO | 04/01/2015 | 3,916 |
| Schall Thomas J. | President and CEO | 03/31/2015 | 9,924 |
| Schall Thomas J. | President and CEO | 03/30/2015 | 720 |
| Schall Thomas J. | President and CEO | 04/01/2015 | 48,047 |
| Schall Thomas J. | President and CEO | 03/31/2015 | 124,920 |
| Schall Thomas J. | President and CEO | 03/30/2015 | 9,009 |
| Schall Thomas J. | President and CEO | 03/25/2015 | 540 |
| Schall Thomas J. | President and CEO | 03/25/2015 | 6,812 |
| Schall Thomas J. | President and CEO | 03/20/2015 | 8,589 |
| Schall Thomas J. | President and CEO | 03/24/2015 | 10,059 |
| Schall Thomas J. | President and CEO | 03/23/2015 | 11,575 |
| Schall Thomas J. | President and CEO | 03/20/2015 | 114,458 |
| Schall Thomas J. | President and CEO | 03/24/2015 | 130,839 |
| Schall Thomas J. | President and CEO | 03/23/2015 | 149,858 |
| Schall Thomas J. | President and CEO | 03/19/2015 | 5,080 |
| Schall Thomas J. | President and CEO | 03/18/2015 | 5,807 |
| Schall Thomas J. | President and CEO | 03/19/2015 | 69,794 |
| Schall Thomas J. | President and CEO | 03/18/2015 | 81,516 |
| Schall Thomas J. | President and CEO | 03/17/2015 | 5,154 |
| Schall Thomas J. | President and CEO | 03/16/2015 | 13,636 |
| Schall Thomas J. | President and CEO | 03/16/2015 | 194,128 |
| Schall Thomas J. | President and CEO | 03/17/2015 | 73,692 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/06/2015 | 10,633 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/05/2015 | 5,187 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/09/2015 | 4,655 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/05/2015 | 69,069 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/09/2015 | 60,079 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/06/2015 | 137,476 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/03/2015 | 3,566 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/02/2015 | 8,634 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/04/2015 | 12,325 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/02/2015 | 116,975 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/04/2015 | 162,686 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/03/2015 | 46,430 |
| Duliege Anne-Marie | EVP, Chief of Strategic Dev. | 11/18/2014 | 23,432 |
| Schall Thomas J. | President and CEO | 05/01/2014 | 16,636 |
| Schall Thomas J. | President and CEO | 05/01/2014 | 154,875 |
| Schall Thomas J. | President and CEO | 04/29/2014 | 8,425 |
| Schall Thomas J. | President and CEO | 04/28/2014 | 10,940 |
| Schall Thomas J. | President and CEO | 04/28/2014 | 97,127 |
| Schall Thomas J. | President and CEO | 04/29/2014 | 76,595 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 04/22/2014 | 8,827 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 04/22/2014 | 84,195 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/05/2013 | 87,009 |
| Schall Thomas J. | President and CEO | 03/17/2014 | 12,000 |
| Schall Thomas J. | President and CEO | 03/17/2014 | 145,000 |
| Schall Thomas J. | President and CEO | 02/18/2014 | 12,000 |
| Schall Thomas J. | President and CEO | 02/18/2014 | 140,932 |
| Parker Geoffrey M. | Director | 12/06/2013 | 77,265 |
| Parker Geoffrey M. | Director | 12/06/2013 | 25,757 |
| BVF PARTNERS L P/IL | 10% Owner | 12/05/2013 | 624,806 |
| BVF PARTNERS L P/IL | 10% Owner | 12/03/2013 | 326,347 |
| BVF PARTNERS L P/IL | 10% Owner | 11/04/2013 | 26,944 |
| BVF PARTNERS L P/IL | 10% Owner | 11/06/2013 | 95,409 |
| BVF PARTNERS L P/IL | 10% Owner | 11/05/2013 | 547,446 |
| BVF PARTNERS L P/IL | 10% Owner | 10/31/2013 | 618,587 |
| BVF PARTNERS L P/IL | 10% Owner | 10/30/2013 | 711,016 |
| BVF PARTNERS L P/IL | 10% Owner | 11/01/2013 | 347,205 |
| BVF PARTNERS L P/IL | 10% Owner | 10/09/2013 | 435,538 |
| BVF PARTNERS L P/IL | 10% Owner | 10/08/2013 | 6,451,372 |
| BVF PARTNERS L P/IL | 10% Owner | 10/03/2013 | 601,203 |
| FECZKO JOSEPH M | Director | 09/13/2013 | 60,257 |
| BVF PARTNERS L P/IL | 10% Owner | 09/13/2013 | 58,924 |
| BVF PARTNERS L P/IL | 10% Owner | 09/11/2013 | 1,877,201 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 08/13/2013 | 9,873 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 08/13/2013 | 70,427 |
| Bekker Petrus | SVP of Medical & Clinical | 08/07/2013 | 30,000 |
| Bekker Petrus | SVP of Medical & Clinical | 08/07/2013 | 66,283 |
| LUCAS ROGER C | Director | 08/05/2013 | 67,083 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 08/01/2013 | 86,378 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 07/17/2013 | 9,873 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 07/17/2013 | 79,239 |
| Bekker Petrus | SVP of Medical & Clinical | 07/17/2013 | 60,000 |
| Bekker Petrus | SVP of Medical & Clinical | 07/17/2013 | 145,394 |
| Schall Thomas J. | President and CEO | 07/16/2013 | 37,595 |
| Schall Thomas J. | President and CEO | 07/15/2013 | 280,360 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 07/02/2013 | 86,758 |
| Schall Thomas J. | President and CEO | 07/01/2013 | 4,510 |
| LUCAS ROGER C | Director | 07/03/2013 | 67,157 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 06/28/2013 | 73,884 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 06/28/2013 | 528,658 |
| Bekker Petrus | SVP of Medical & Clinical | 06/26/2013 | 702 |
| Bekker Petrus | SVP of Medical & Clinical | 06/25/2013 | 11,202 |
| Bekker Petrus | SVP of Medical & Clinical | 06/27/2013 | 18,096 |
| Bekker Petrus | SVP of Medical & Clinical | 06/26/2013 | 1,638 |
| Bekker Petrus | SVP of Medical & Clinical | 06/25/2013 | 26,138 |
| Bekker Petrus | SVP of Medical & Clinical | 06/27/2013 | 42,224 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/21/2013 | 81,250 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/18/2013 | 7,667 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 06/18/2013 | 22,228 |
| Bekker Petrus | SVP of Medical & Clinical | 06/17/2013 | 30,000 |
| Bekker Petrus | SVP of Medical & Clinical | 06/17/2013 | 60,001 |
| LUCAS ROGER C | Director | 06/03/2013 | 66,594 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 05/29/2013 | 4,234 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 05/30/2013 | 21,306 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 05/30/2013 | 152,140 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 05/29/2013 | 30,211 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/28/2013 | 2,206 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/28/2013 | 51,832 |
| Bekker Petrus | SVP of Medical & Clinical | 05/23/2013 | 28,308 |
| Bekker Petrus | SVP of Medical & Clinical | 05/24/2013 | 492 |
| Bekker Petrus | SVP of Medical & Clinical | 05/24/2013 | 1,148 |
| Bekker Petrus | SVP of Medical & Clinical | 05/23/2013 | 66,054 |
| Bekker Petrus | SVP of Medical & Clinical | 05/20/2013 | 1,200 |
| Bekker Petrus | SVP of Medical & Clinical | 05/20/2013 | 2,800 |
| Bekker Petrus | SVP of Medical & Clinical | 05/17/2013 | 30,000 |
| Bekker Petrus | SVP of Medical & Clinical | 05/15/2013 | 60,000 |
| Bekker Petrus | SVP of Medical & Clinical | 05/17/2013 | 67,973 |
| Bekker Petrus | SVP of Medical & Clinical | 05/15/2013 | 141,598 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/15/2013 | 18,845 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 05/15/2013 | 220,637 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 05/15/2013 | 1,598 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 05/15/2013 | 11,486 |
| LUCAS ROGER C | Director | 05/15/2013 | 70,569 |
| Schall Thomas J. | President and CEO | 05/15/2013 | 106,728 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 04/11/2013 | 900 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 04/11/2013 | 21,150 |
| Bekker Petrus | SVP of Medical & Clinical | 04/11/2013 | 23,874 |
| Bekker Petrus | SVP of Medical & Clinical | 04/11/2013 | 55,829 |
| Schall Thomas J. | President and CEO | 04/11/2013 | 32,409 |
| Schall Thomas J. | President and CEO | 04/10/2013 | 3,038 |
| LUCAS ROGER C | Director | 04/03/2013 | 67,468 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 04/03/2013 | 84,175 |
| Bekker Petrus | SVP of Medical & Clinical | 04/02/2013 | 384 |
| Bekker Petrus | SVP of Medical & Clinical | 04/01/2013 | 5,742 |
| Bekker Petrus | SVP of Medical & Clinical | 04/02/2013 | 896 |
| Bekker Petrus | SVP of Medical & Clinical | 04/01/2013 | 13,398 |
| Schall Thomas J. | President and CEO | 04/02/2013 | 2,800 |
| Schall Thomas J. | President and CEO | 04/01/2013 | 7,784 |
| Schall Thomas J. | President and CEO | 03/18/2013 | 1,031 |
| Schall Thomas J. | President and CEO | 03/15/2013 | 235,792 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 03/15/2013 | 3,978 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 03/15/2013 | 28,383 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/15/2013 | 1,966 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/19/2013 | 7,667 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/15/2013 | 46,568 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/19/2013 | 24,080 |
| Bekker Petrus | SVP of Medical & Clinical | 03/18/2013 | 16,500 |
| Bekker Petrus | SVP of Medical & Clinical | 03/15/2013 | 53,334 |
| Bekker Petrus | SVP of Medical & Clinical | 03/18/2013 | 68,056 |
| Bekker Petrus | SVP of Medical & Clinical | 03/15/2013 | 124,953 |
| Bekker Petrus | SVP of Medical & Clinical | 03/14/2013 | 5,400 |
| Bekker Petrus | SVP of Medical & Clinical | 03/13/2013 | 19,272 |
| Bekker Petrus | SVP of Medical & Clinical | 03/12/2013 | 25,656 |
| Bekker Petrus | SVP of Medical & Clinical | 03/14/2013 | 12,600 |
| Bekker Petrus | SVP of Medical & Clinical | 03/13/2013 | 44,968 |
| Bekker Petrus | SVP of Medical & Clinical | 03/12/2013 | 59,864 |
| Schall Thomas J. | President and CEO | 03/13/2013 | 27,720 |
| Schall Thomas J. | President and CEO | 03/12/2013 | 35,042 |
| Schall Thomas J. | President and CEO | 03/14/2013 | 5,908 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/11/2013 | 240 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 03/11/2013 | 5,662 |
| Bekker Petrus | SVP of Medical & Clinical | 03/08/2013 | 28,488 |
| Bekker Petrus | SVP of Medical & Clinical | 03/07/2013 | 11,099 |
| Bekker Petrus | SVP of Medical & Clinical | 03/11/2013 | 47,850 |
| Bekker Petrus | SVP of Medical & Clinical | 03/08/2013 | 66,472 |
| Bekker Petrus | SVP of Medical & Clinical | 03/07/2013 | 255,761 |
| Bekker Petrus | SVP of Medical & Clinical | 03/11/2013 | 111,694 |
| Schall Thomas J. | President and CEO | 03/11/2013 | 54,235 |
| Schall Thomas J. | President and CEO | 03/08/2013 | 43,050 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 03/07/2013 | 9,765 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 03/08/2013 | 29,284 |
| Schall Thomas J. | President and CEO | 03/06/2013 | 16,156 |
| Schall Thomas J. | President and CEO | 03/05/2013 | 18,593 |
| Schall Thomas J. | President and CEO | 03/04/2013 | 42,896 |
| LUCAS ROGER C | Director | 03/04/2013 | 69,327 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 03/05/2013 | 41,209 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 03/04/2013 | 69,935 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 03/06/2013 | 59,329 |
| Bekker Petrus | SVP of Medical & Clinical | 03/04/2013 | 2,736 |
| Bekker Petrus | SVP of Medical & Clinical | 03/06/2013 | 3,120 |
| Bekker Petrus | SVP of Medical & Clinical | 03/05/2013 | 1,045 |
| Bekker Petrus | SVP of Medical & Clinical | 03/04/2013 | 63,840 |
| Bekker Petrus | SVP of Medical & Clinical | 03/06/2013 | 72,458 |
| Bekker Petrus | SVP of Medical & Clinical | 03/05/2013 | 24,447 |
| Schall Thomas J. | President and CEO | 03/01/2013 | 82,421 |
| Schall Thomas J. | President and CEO | 02/28/2013 | 121,743 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/28/2013 | 21,926 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/27/2013 | 32,250 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/28/2013 | 66,920 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/27/2013 | 94,179 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/28/2013 | 330,509 |
| Bekker Petrus | SVP of Medical & Clinical | 02/22/2013 | 9,000 |
| Bekker Petrus | SVP of Medical & Clinical | 02/22/2013 | 181,102 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 02/22/2013 | 1,332 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 02/22/2013 | 7,934 |
| Schall Thomas J. | President and CEO | 02/22/2013 | 90,474 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/25/2013 | 32,250 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/22/2013 | 32,250 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/26/2013 | 32,250 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/22/2013 | 90,383 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/26/2013 | 92,756 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/25/2013 | 92,067 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 02/20/2013 | 12,244 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 02/19/2013 | 15,450 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 02/21/2013 | 10,974 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 02/20/2013 | 72,988 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 02/19/2013 | 92,075 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 02/21/2013 | 65,248 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/20/2013 | 24,084 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/19/2013 | 32,250 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/21/2013 | 4,730 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/20/2013 | 66,633 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/19/2013 | 184,535 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/21/2013 | 13,079 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/15/2013 | 8,364 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/15/2013 | 22,825 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/13/2013 | 9,873 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 02/13/2013 | 62,496 |
| LUCAS ROGER C | Director | 02/07/2013 | 12,884 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/07/2013 | 6,687 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/07/2013 | 18,116 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/04/2013 | 16,663 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/04/2013 | 45,294 |
| LUCAS ROGER C | Director | 02/06/2013 | 8,548 |
| LUCAS ROGER C | Director | 02/05/2013 | 9,069 |
| LUCAS ROGER C | Director | 02/04/2013 | 26,809 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/31/2013 | 14,104 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/01/2013 | 28,918 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 02/01/2013 | 78,106 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/31/2013 | 37,752 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/29/2013 | 21,036 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/28/2013 | 11,653 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/25/2013 | 413 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/29/2013 | 56,013 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/28/2013 | 30,851 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/25/2013 | 1,090 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/24/2013 | 5,160 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/22/2013 | 430 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/24/2013 | 13,622 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/22/2013 | 1,135 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/18/2013 | 1,655 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/18/2013 | 30,799 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/17/2013 | 2,197 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/16/2013 | 2,580 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/15/2013 | 3,440 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/17/2013 | 14,501 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/16/2013 | 6,705 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 01/15/2013 | 8,920 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/12/2013 | 14,212 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/12/2013 | 37,512 |
| LUCAS ROGER C | Director | 01/08/2013 | 23,098 |
| LUCAS ROGER C | Director | 01/07/2013 | 20,094 |
| LUCAS ROGER C | Director | 01/04/2013 | 7,759 |
| LUCAS ROGER C | Director | 01/03/2013 | 4,453 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/04/2013 | 413 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/03/2013 | 430 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/02/2013 | 25,030 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/03/2013 | 1,135 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/02/2013 | 65,568 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 01/04/2013 | 1,090 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 12/18/2012 | 9,503 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 12/18/2012 | 52,984 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 12/18/2012 | 32,250 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 12/17/2012 | 32,250 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 12/18/2012 | 83,375 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 12/17/2012 | 82,375 |
| LUCAS ROGER C | Director | 12/04/2012 | 57,443 |
| LUCAS ROGER C | Director | 12/03/2012 | 2,344 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 12/04/2012 | 9,386 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 12/03/2012 | 808 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 11/30/2012 | 1,660 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 12/04/2012 | 56,217 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 12/03/2012 | 4,818 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 11/30/2012 | 9,910 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 11/29/2012 | 7,678 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 11/28/2012 | 468 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 11/29/2012 | 45,663 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 11/28/2012 | 2,784 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/26/2012 | 121 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/26/2012 | 2,432 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/23/2012 | 1,920 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/21/2012 | 5,990 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/21/2012 | 16,578 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/23/2012 | 9,558 |
| Schall Thomas J. | President and CEO | 11/20/2012 | 11,997 |
| Schall Thomas J. | President and CEO | 11/19/2012 | 13,232 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/20/2012 | 2 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/19/2012 | 4 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/19/2012 | 85 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/20/2012 | 36 |
| Bekker Petrus | SVP of Medical & Clinical | 11/20/2012 | 2,063 |
| Bekker Petrus | SVP of Medical & Clinical | 11/19/2012 | 937 |
| Bekker Petrus | SVP of Medical & Clinical | 11/16/2012 | 119,000 |
| Bekker Petrus | SVP of Medical & Clinical | 11/20/2012 | 41,313 |
| Bekker Petrus | SVP of Medical & Clinical | 11/19/2012 | 18,749 |
| BVF PARTNERS L P/IL | 10% Owner | 11/06/2012 | 479,828 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 11/14/2012 | 25,900 |
| Schall Thomas J. | President and CEO | 11/16/2012 | 24,000 |
| Schall Thomas J. | President and CEO | 11/15/2012 | 41,423 |
| Schall Thomas J. | President and CEO | 11/14/2012 | 191,250 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 11/06/2012 | 70,030 |
| Bekker Petrus | SVP of Medical & Clinical | 11/06/2012 | 5,580 |
| Bekker Petrus | SVP of Medical & Clinical | 11/06/2012 | 111,697 |
| Schall Thomas J. | President and CEO | 11/06/2012 | 270,161 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/06/2012 | 2,206 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 11/06/2012 | 44,480 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 11/06/2012 | 32,058 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 11/06/2012 | 190,909 |
| BVF PARTNERS L P/IL | 10% Owner | 11/06/2012 | 479,828 |
| LUCAS ROGER C | Director | 11/06/2012 | 29,572 |
| LUCAS ROGER C | Director | 11/05/2012 | 28,357 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 10/19/2012 | 1,740 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 10/18/2012 | 17,815 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 10/22/2012 | 190 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 10/19/2012 | 31,914 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 10/18/2012 | 83,410 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 10/22/2012 | 3,380 |
| LUCAS ROGER C | Director | 10/04/2012 | 21,711 |
| LUCAS ROGER C | Director | 10/03/2012 | 35,372 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 10/01/2012 | 7,942 |
| KANAYA SUSAN M | SVP, Finance, CFO and Sec. | 10/01/2012 | 47,216 |
| Schall Thomas J. | President and CEO | 10/01/2012 | 172,955 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 09/27/2012 | 3,586 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 10/01/2012 | 25,157 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 09/25/2012 | 9,873 |
| Cappel Markus J. | Chief Bus. Officer & Treasurer | 09/25/2012 | 64,725 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 09/25/2012 | 88,480 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 09/24/2012 | 32,358 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 09/21/2012 | 2,402 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 09/20/2012 | 7,937 |
| Bekker Petrus | SVP of Medical & Clinical | 09/20/2012 | 120 |
| Bekker Petrus | SVP of Medical & Clinical | 09/24/2012 | 60 |
| Bekker Petrus | SVP of Medical & Clinical | 09/24/2012 | 1,201 |
| Bekker Petrus | SVP of Medical & Clinical | 09/20/2012 | 2,404 |
| Jaen Juan C. | SVP, Drug Discovery & CSO | 09/17/2012 | 9,638 |
| Bekker Petrus | SVP of Medical & Clinical | 09/17/2012 | 240 |
| Bekker Petrus | SVP of Medical & Clinical | 09/17/2012 | 4,849 |
| LUCAS ROGER C | Director | 09/18/2012 | 14,054 |
| LUCAS ROGER C | Director | 09/17/2012 | 45,286 |
| TECHNE CORP /MN/ | 10% Owner | 02/13/2012 | 5,000,000 |
| Parker Geoffrey M. | Director | 02/10/2012 | 50,462 |
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