Biomarin Pharmaceutical Inc.. (BMRN) NASDAQ
$96.94 1.87 (1.97%)
Market Cap: $17.63B
As of 08/15/22 03:59 PM EDT. Market closed.
Biomarin Pharmaceutical Inc.. (BMRN) NASDAQ
$96.94 1.87 (1.97%)
Market Cap: $17.63B
As of 08/15/22 03:59 PM EDT. Market closed.
BioMarin is a global biotechnology company that develops and commercializes innovative therapies for serious and life-threatening rare and ultra-rare genetic diseases. The Company's portfolio consists of six commercialized products and multiple clinical and pre-clinical product ... read more
BioMarin is a global biotechnology company that develops and commercializes innovative therapies for serious and life-threatening rare and ultra-rare genetic diseases. The Company's portfolio consists of six commercialized products and multiple clinical and pre-clinical product candidates. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
Jean-Jacques Bienaime
Full Time Employees
3,059
CEO Compensation (Base)
$1.15M
CEO Compensation (Total)
$15.63M
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
Jean-Jacques Bienaime
Full Time Employees
3,059
CEO Compensation (Base)
$1.15M
CEO Compensation (Total)
$15.63M
URL
Address
105 Digital Dr, California, Novato, 94949-8703.
PRICE CHART
From:
To:
NEWS
KEY STATS
Open
$95.32
Previous Close
$95.07
Days Range
$94.14 - $95.43
52 week range
$70.73 - $97.76
Volume
1,169,531
Avg. Volume (30 days)
1,093,639
Market Cap
$17.63B
Dividend Yield
0.00%
P/E
326.11
Shares Outstanding
185,473,867
Open
$95.32
Previous Close
$95.07
Days Range
$94.14 - $95.43
52 week range
$70.73 - $97.76
Volume
1,169,531
Avg. Volume (30 days)
1,093,639
Market Cap
$17.63B
Dividend Yield
0.00%
P/E
326.11
Shares Outstanding
185,473,867
Open in:
Open in:
INSIDER TRANSACTIONS FOR BIOMARIN PHARMACEUTICAL INC.
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Aug 11, 2022 | Sale | $95.62 | 3,000 | 286,860 | 44,088 | Aug 12, 2022, 07:07 PM |
| Davis George Eric | EVP, Chief Legal Officer | Aug 09, 2022 | Option Exercise | $67.81 | 47,526 | 3,222,738 | 102,777 | Aug 11, 2022, 09:01 PM |
| Davis George Eric | EVP, Chief Legal Officer | Aug 09, 2022 | Sale | $95.96 | 51,216 | 4,914,664 | 55,251 | Aug 11, 2022, 09:01 PM |
| Guyer Charles Greg | EVP, Chief Technical Officer | Aug 08, 2022 | Sale | $96.56 | 6,205 | 599,155 | 42,168 | Aug 10, 2022, 07:52 PM |
| Mueller Brian | EVP, Chief Financial Officer | Aug 05, 2022 | Option Exercise | $67.81 | 3,500 | 237,335 | 34,226 | Aug 09, 2022, 07:27 PM |
| Mueller Brian | EVP, Chief Financial Officer | Aug 05, 2022 | Sale | $94.50 | 3,500 | 330,750 | 30,726 | Aug 09, 2022, 07:27 PM |
| Mueller Brian | EVP, Chief Financial Officer | Jul 08, 2022 | Sale | $89.50 | 7,337 | 656,662 | 30,726 | Jul 12, 2022, 02:25 PM |
| Davis George Eric | EVP, Chief Legal Officer | Jul 08, 2022 | Sale | $90.00 | 7,398 | 665,820 | 58,941 | Jul 11, 2022, 07:46 PM |
| Mueller Brian | EVP, Chief Financial Officer | Jun 29, 2022 | Option Exercise | $83.92 | 576 | 48,338 | 38,063 | Jul 01, 2022, 03:25 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jun 03, 2022 | Option Exercise | $77.49 | 7,021 | 544,057 | 47,088 | Jun 07, 2022, 02:46 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 29, 2022 | Option Exercise | $62.41 | 340 | 21,218 | 55,417 | May 31, 2022, 09:29 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 26, 2022 | Sale | $78.94 | 1,308 | 103,254 | 54,109 | May 31, 2022, 09:29 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 29, 2022 | Option Exercise | $62.41 | 341 | 21,281 | 335,324 | May 09, 2022, 09:29 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2022 | Option Exercise | $37.46 | 10,000 | 374,600 | 345,324 | May 09, 2022, 09:29 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 06, 2022 | Option Exercise | $37.46 | 20,000 | 749,200 | 355,324 | May 09, 2022, 09:29 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2022 | Sale | $84.14 | 10,000 | 841,400 | 335,324 | May 09, 2022, 09:29 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 06, 2022 | Sale | $81.00 | 20,000 | 1,620,000 | 335,324 | May 09, 2022, 09:29 PM |
| Guyer Charles Greg | EVP, Chief Technical Officer | Apr 29, 2022 | Option Exercise | $62.41 | 243 | 15,165 | 52,299 | May 06, 2022, 08:19 PM |
| Guyer Charles Greg | EVP, Chief Technical Officer | May 04, 2022 | Option Exercise | $84.65 | 3,926 | 332,336 | 48,373 | May 06, 2022, 08:19 PM |
| Mueller Brian | EVP, Chief Financial Officer | Apr 29, 2022 | Option Exercise | $62.41 | 340 | 21,218 | 38,639 | May 06, 2022, 07:45 PM |
| Mueller Brian | EVP, Chief Financial Officer | May 04, 2022 | Option Exercise | $37.46 | 11,800 | 442,028 | 48,401 | May 06, 2022, 07:45 PM |
| Mueller Brian | EVP, Chief Financial Officer | May 04, 2022 | Sale | $84.50 | 11,800 | 997,100 | 38,639 | May 06, 2022, 07:45 PM |
| MEIER RICHARD A | Director | May 02, 2022 | Option Exercise | $37.46 | 8,500 | 318,410 | 107,892 | May 04, 2022, 12:21 PM |
| MEIER RICHARD A | Director | May 02, 2022 | Sale | $82.09 | 3,878 | 318,345 | 104,032 | May 04, 2022, 12:21 PM |
| Davis George Eric | EVP, Chief Legal Officer | Apr 29, 2022 | Option Exercise | $62.41 | 341 | 21,281 | 66,339 | May 04, 2022, 12:01 PM |
| Davis George Eric | EVP, Chief Legal Officer | May 02, 2022 | Option Exercise | $37.46 | 15,347 | 574,899 | 81,686 | May 04, 2022, 12:01 PM |
| Davis George Eric | EVP, Chief Legal Officer | May 02, 2022 | Sale | $80.38 | 15,347 | 1,233,592 | 66,339 | May 04, 2022, 12:01 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 28, 2022 | Option Exercise | $37.46 | 20,000 | 749,200 | 354,983 | May 02, 2022, 09:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 29, 2022 | Option Exercise | $37.46 | 5,000 | 187,300 | 339,983 | May 02, 2022, 09:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 29, 2022 | Sale | $81.95 | 5,000 | 409,750 | 334,983 | May 02, 2022, 09:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 28, 2022 | Sale | $83.79 | 20,000 | 1,675,800 | 334,983 | May 02, 2022, 09:27 PM |
| Davis George Eric | EVP, Chief Legal Officer | Apr 25, 2022 | Option Exercise | $37.46 | 2,669 | 99,981 | 65,998 | Apr 27, 2022, 08:40 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 18, 2022 | Option Exercise | $37.46 | 20,000 | 749,200 | 354,983 | Apr 20, 2022, 08:20 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 18, 2022 | Sale | $81.91 | 20,000 | 1,638,200 | 334,983 | Apr 20, 2022, 08:20 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 14, 2022 | Option Exercise | $37.46 | 10,000 | 374,600 | 344,983 | Apr 18, 2022, 09:46 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 14, 2022 | Sale | $83.66 | 10,000 | 836,600 | 334,983 | Apr 18, 2022, 09:46 PM |
| LAWLIS V BRYAN | Director | Apr 14, 2022 | Option Exercise | $37.46 | 4,250 | 159,205 | 28,220 | Apr 18, 2022, 08:22 PM |
| LAWLIS V BRYAN | Director | Apr 14, 2022 | Sale | $83.66 | 4,250 | 355,555 | 23,970 | Apr 18, 2022, 08:22 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 13, 2022 | Sale | $82.47 | 1,180 | 97,315 | 55,077 | Apr 14, 2022, 07:54 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 30, 2022 | Sale | $79.56 | 1,381 | 109,872 | 56,257 | Mar 31, 2022, 09:28 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 29, 2022 | Sale | $79.43 | 1,618 | 128,518 | 57,638 | Mar 31, 2022, 09:28 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 23, 2022 | Sale | $81.78 | 6,129 | 501,230 | 59,256 | Mar 24, 2022, 08:49 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 22, 2022 | Sale | $81.00 | 2,073 | 167,913 | 65,385 | Mar 24, 2022, 08:49 PM |
| Davis George Eric | EVP, General Counsel | Mar 21, 2022 | Sale | $81.29 | 6,129 | 498,226 | 63,329 | Mar 23, 2022, 09:16 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 16, 2022 | Option Exercise | $80.72 | 2,259 | 182,346 | 143,753 | Mar 17, 2022, 09:47 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 15, 2022 | Option Exercise | $78.27 | 12,101 | 947,145 | 146,012 | Mar 17, 2022, 09:47 PM |
| Mueller Brian | EVP, Chief Financial Officer | Mar 16, 2022 | Option Exercise | $80.72 | 582 | 46,979 | 38,299 | Mar 17, 2022, 09:38 PM |
| Mueller Brian | EVP, Chief Financial Officer | Mar 15, 2022 | Option Exercise | $78.27 | 1,868 | 146,208 | 38,881 | Mar 17, 2022, 09:38 PM |
| Guyer Charles Greg | EVP, Chief Technical Officer | Mar 15, 2022 | Option Exercise | $78.27 | 920 | 72,008 | 52,056 | Mar 17, 2022, 09:30 PM |
| Davis George Eric | EVP, General Counsel | Mar 16, 2022 | Option Exercise | $80.72 | 1,252 | 101,061 | 69,458 | Mar 17, 2022, 09:24 PM |
| Davis George Eric | EVP, General Counsel | Mar 15, 2022 | Option Exercise | $78.27 | 8,290 | 648,858 | 70,710 | Mar 17, 2022, 09:24 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2022 | Option Exercise | $78.27 | 38,306 | 2,998,210 | 340,543 | Mar 17, 2022, 09:18 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 16, 2022 | Option Exercise | $80.72 | 5,560 | 448,803 | 334,983 | Mar 17, 2022, 09:18 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 16, 2022 | Option Exercise | $80.72 | 1,287 | 103,887 | 67,458 | Mar 17, 2022, 09:11 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 15, 2022 | Option Exercise | $78.27 | 8,418 | 658,877 | 68,745 | Mar 17, 2022, 09:11 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 10, 2022 | Option Exercise | $37.46 | 15,000 | 561,900 | 353,569 | Mar 14, 2022, 08:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 11, 2022 | Option Exercise | $37.46 | 15,000 | 561,900 | 353,569 | Mar 14, 2022, 08:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 10, 2022 | Sale | $77.57 | 15,000 | 1,163,550 | 338,569 | Mar 14, 2022, 08:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 11, 2022 | Sale | $77.81 | 15,000 | 1,167,150 | 338,569 | Mar 14, 2022, 08:44 PM |
| Slamon Dennis | Director | Feb 28, 2022 | Sale | $78.33 | 6,396 | 501,013 | 22,220 | Mar 02, 2022, 04:57 PM |
| HERON ELAINE J | Director | Feb 25, 2022 | Option Exercise | $37.46 | 8,500 | 318,410 | 80,588 | Feb 28, 2022, 09:52 PM |
| Mueller Brian | EVP, Chief Financial Officer | Feb 03, 2022 | Option Exercise | $87.77 | 1,072 | 94,089 | 29,709 | Feb 07, 2022, 08:48 PM |
| LAWLIS V BRYAN | Director | Jan 14, 2022 | Option Exercise | $37.46 | 4,250 | 159,205 | 28,220 | Jan 19, 2022, 06:34 PM |
| LAWLIS V BRYAN | Director | Jan 14, 2022 | Sale | $87.61 | 4,250 | 372,343 | 23,970 | Jan 19, 2022, 06:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 21, 2021 | Option Exercise | $89.22 | 100 | 8,922 | 303,789 | Jan 14, 2022, 08:45 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 13, 2022 | Option Exercise | $37.46 | 5,000 | 187,300 | 308,789 | Jan 14, 2022, 08:45 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 12, 2022 | Option Exercise | $37.46 | 5,000 | 187,300 | 308,789 | Jan 14, 2022, 08:45 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 13, 2022 | Sale | $87.86 | 5,000 | 439,300 | 303,789 | Jan 14, 2022, 08:45 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 12, 2022 | Sale | $89.00 | 5,000 | 445,000 | 303,789 | Jan 14, 2022, 08:45 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 16, 2021 | Option Exercise | $37.46 | 6,000 | 224,760 | 309,689 | Dec 17, 2021, 07:03 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 15, 2021 | Option Exercise | $37.46 | 6,000 | 224,760 | 309,689 | Dec 17, 2021, 07:03 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 16, 2021 | Sale | $84.68 | 6,000 | 508,080 | 303,689 | Dec 17, 2021, 07:03 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 15, 2021 | Sale | $82.71 | 6,000 | 496,260 | 303,689 | Dec 17, 2021, 07:03 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 09, 2021 | Option Exercise | $78.77 | 50 | 3,938 | 305,889 | Dec 02, 2021, 09:42 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 01, 2021 | Sale | $87.22 | 1,500 | 130,832 | 304,389 | Dec 02, 2021, 09:42 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 30, 2021 | Option Exercise | $62.41 | 342 | 21,343 | 58,592 | Oct 28, 2021, 07:48 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Oct 26, 2021 | Sale | $73.60 | 2,739 | 201,590 | 55,853 | Oct 28, 2021, 07:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 20, 2021 | Option Exercise | $37.46 | 1,000 | 37,460 | 305,839 | Oct 22, 2021, 04:36 PM |
| Davis George Eric | EVP, General Counsel | Aug 02, 2021 | Sale | $76.69 | 5,518 | 423,175 | 58,590 | Aug 04, 2021, 04:59 PM |
| Acosta Andrea | GVP, Chief Accounting Officer | Apr 30, 2021 | Option Exercise | $62.41 | 271 | 16,912 | 18,407 | Jul 19, 2021, 08:55 PM |
| Acosta Andrea | GVP, Chief Accounting Officer | Jul 16, 2021 | Option Exercise | $78.84 | 285 | 22,469 | 18,122 | Jul 19, 2021, 08:55 PM |
| Mueller Brian | EVP, Chief Financial Officer | Jun 29, 2021 | Option Exercise | $83.46 | 576 | 48,073 | 30,781 | Jun 30, 2021, 08:18 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 21, 2021 | Option Exercise | $37.46 | 1,000 | 37,460 | 304,839 | Jun 23, 2021, 05:04 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 10, 2021 | Option Exercise | $26.49 | 8,513 | 225,509 | 312,352 | May 12, 2021, 07:21 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 10, 2021 | Sale | $77.29 | 8,513 | 657,970 | 303,839 | May 12, 2021, 07:21 PM |
| Mueller Brian | EVP, Chief Financial Officer | Apr 30, 2021 | Option Exercise | $62.41 | 341 | 21,281 | 31,357 | May 11, 2021, 07:42 PM |
| Mueller Brian | EVP, Chief Financial Officer | May 07, 2021 | Option Exercise | $28.23 | 6,709 | 189,395 | 38,066 | May 11, 2021, 07:42 PM |
| Mueller Brian | EVP, Chief Financial Officer | May 07, 2021 | Sale | $79.50 | 6,709 | 533,366 | 31,357 | May 11, 2021, 07:42 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 30, 2021 | Option Exercise | $62.41 | 341 | 21,281 | 303,839 | May 10, 2021, 09:07 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 07, 2021 | Option Exercise | $26.49 | 25,000 | 662,250 | 328,839 | May 10, 2021, 09:07 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 06, 2021 | Option Exercise | $26.49 | 25,000 | 662,250 | 328,839 | May 10, 2021, 09:07 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 06, 2021 | Sale | $78.29 | 25,000 | 1,957,199 | 314,014 | May 10, 2021, 09:07 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 07, 2021 | Sale | $78.12 | 25,000 | 1,953,121 | 313,283 | May 10, 2021, 09:07 PM |
| MEIER RICHARD A | Director | May 06, 2021 | Option Exercise | $26.49 | 15,000 | 397,350 | 99,340 | May 07, 2021, 07:48 PM |
| MEIER RICHARD A | Director | May 06, 2021 | Sale | $78.38 | 5,068 | 397,245 | 94,272 | May 07, 2021, 07:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 23, 2021 | Option Exercise | $26.49 | 10,000 | 264,900 | 312,498 | Apr 26, 2021, 08:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 22, 2021 | Option Exercise | $26.49 | 10,000 | 264,900 | 312,498 | Apr 26, 2021, 08:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 23, 2021 | Sale | $79.34 | 10,000 | 793,400 | 302,498 | Apr 26, 2021, 08:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 22, 2021 | Sale | $78.91 | 10,000 | 789,100 | 302,498 | Apr 26, 2021, 08:44 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 08, 2021 | Sale | $78.81 | 1,537 | 121,131 | 58,250 | Apr 09, 2021, 05:57 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 30, 2021 | Sale | $74.79 | 1,652 | 123,553 | 59,787 | Apr 01, 2021, 02:17 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 24, 2021 | Sale | $76.30 | 1,181 | 90,110 | 61,439 | Mar 26, 2021, 05:45 PM |
| Mueller Brian | EVP, Chief Financial Officer | Mar 22, 2021 | Option Exercise | $78.52 | 516 | 40,516 | 36,708 | Mar 23, 2021, 09:22 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 22, 2021 | Option Exercise | $78.52 | 2,454 | 192,688 | 106,142 | Mar 23, 2021, 09:12 PM |
| Davis George Eric | EVP, General Counsel | Mar 22, 2021 | Option Exercise | $78.52 | 1,391 | 109,221 | 68,440 | Mar 23, 2021, 09:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 22, 2021 | Option Exercise | $78.52 | 5,519 | 433,352 | 302,498 | Mar 23, 2021, 08:50 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 22, 2021 | Option Exercise | $78.52 | 1,513 | 118,801 | 62,620 | Mar 23, 2021, 08:40 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 18, 2021 | Sale | $77.99 | 1,308 | 102,011 | 64,133 | Mar 19, 2021, 09:01 PM |
| Mueller Brian | EVP, Chief Financial Officer | Mar 16, 2021 | Option Exercise | $77.21 | 582 | 44,936 | 37,224 | Mar 17, 2021, 09:39 PM |
| Mueller Brian | EVP, Chief Financial Officer | Mar 15, 2021 | Option Exercise | $78.39 | 994 | 77,920 | 37,806 | Mar 17, 2021, 09:39 PM |
| Davis George Eric | EVP, General Counsel | Mar 16, 2021 | Option Exercise | $77.21 | 1,252 | 96,667 | 69,831 | Mar 17, 2021, 09:35 PM |
| Davis George Eric | EVP, General Counsel | Mar 15, 2021 | Option Exercise | $78.39 | 5,014 | 393,047 | 71,083 | Mar 17, 2021, 09:35 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 16, 2021 | Option Exercise | $77.21 | 2,259 | 174,417 | 108,596 | Mar 17, 2021, 09:31 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 15, 2021 | Option Exercise | $78.39 | 7,460 | 584,789 | 110,855 | Mar 17, 2021, 09:31 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 16, 2021 | Option Exercise | $77.21 | 1,287 | 99,369 | 65,441 | Mar 17, 2021, 09:27 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 15, 2021 | Option Exercise | $78.39 | 5,273 | 413,350 | 66,728 | Mar 17, 2021, 09:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 16, 2021 | Option Exercise | $77.21 | 5,559 | 429,210 | 308,017 | Mar 17, 2021, 09:24 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2021 | Option Exercise | $78.39 | 23,426 | 1,836,364 | 313,576 | Mar 17, 2021, 09:24 PM |
| Acosta Andrea | GVP, Chief Accounting Officer | Mar 16, 2021 | Option Exercise | $77.21 | 379 | 29,263 | 18,136 | Mar 17, 2021, 09:21 PM |
| Acosta Andrea | GVP, Chief Accounting Officer | Mar 15, 2021 | Option Exercise | $78.39 | 553 | 43,350 | 18,515 | Mar 17, 2021, 09:21 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 04, 2021 | Option Exercise | $77.94 | 100 | 7,794 | 295,652 | Mar 15, 2021, 08:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 12, 2021 | Option Exercise | $26.49 | 7,000 | 185,430 | 302,652 | Mar 15, 2021, 08:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 11, 2021 | Option Exercise | $26.49 | 7,000 | 185,430 | 302,652 | Mar 15, 2021, 08:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 11, 2021 | Sale | $77.68 | 7,000 | 543,760 | 295,652 | Mar 15, 2021, 08:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 12, 2021 | Sale | $77.10 | 7,000 | 539,700 | 295,652 | Mar 15, 2021, 08:26 PM |
| GREY MICHAEL G | Director | Mar 05, 2021 | Option Exercise | $26.49 | 5,000 | 132,450 | 47,840 | Mar 09, 2021, 05:59 PM |
| GREY MICHAEL G | Director | Mar 05, 2021 | Sale | $76.28 | 5,000 | 381,400 | 42,840 | Mar 09, 2021, 05:59 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 19, 2021 | Option Exercise | $26.49 | 7,000 | 185,430 | 302,552 | Feb 22, 2021, 08:38 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 19, 2021 | Sale | $83.58 | 7,000 | 585,060 | 295,552 | Feb 22, 2021, 08:38 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 18, 2021 | Option Exercise | $26.49 | 7,000 | 185,430 | 302,552 | Feb 19, 2021, 09:22 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 18, 2021 | Sale | $85.08 | 7,000 | 595,560 | 295,552 | Feb 19, 2021, 09:22 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 17, 2021 | Option Exercise | $26.49 | 8,000 | 211,920 | 303,552 | Feb 18, 2021, 09:45 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 17, 2021 | Sale | $84.54 | 8,000 | 676,320 | 295,552 | Feb 18, 2021, 09:45 PM |
| LAWLIS V BRYAN | Director | Feb 16, 2021 | Option Exercise | $26.49 | 7,500 | 198,675 | 26,350 | Feb 18, 2021, 06:43 PM |
| LAWLIS V BRYAN | Director | Feb 16, 2021 | Sale | $87.41 | 7,500 | 655,575 | 18,850 | Feb 18, 2021, 06:43 PM |
| Mueller Brian | EVP, Chief Financial Officer | Feb 03, 2021 | Option Exercise | $82.82 | 1,071 | 88,700 | 28,673 | Feb 04, 2021, 07:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 29, 2021 | Option Exercise | $26.49 | 8,334 | 220,768 | 303,886 | Feb 01, 2021, 07:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 28, 2021 | Option Exercise | $26.49 | 8,333 | 220,741 | 303,885 | Feb 01, 2021, 07:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 28, 2021 | Sale | $82.91 | 8,333 | 690,889 | 295,552 | Feb 01, 2021, 07:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 29, 2021 | Sale | $82.67 | 8,334 | 688,972 | 295,552 | Feb 01, 2021, 07:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 27, 2021 | Option Exercise | $26.49 | 8,333 | 220,741 | 303,885 | Jan 28, 2021, 07:35 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 27, 2021 | Sale | $85.49 | 8,333 | 712,388 | 295,552 | Jan 28, 2021, 07:35 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 29, 2020 | Sale | $88.18 | 1,500 | 132,270 | 295,552 | Dec 30, 2020, 08:02 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 28, 2020 | Sale | $88.77 | 1,500 | 133,155 | 297,052 | Dec 30, 2020, 08:02 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Oct 14, 2020 | Sale | $79.91 | 2,121 | 169,489 | 61,281 | Oct 15, 2020, 07:17 PM |
| HERON ELAINE J | Director | Oct 07, 2020 | Option Exercise | $26.49 | 15,000 | 397,350 | 66,968 | Oct 08, 2020, 08:35 PM |
| PYOTT DAVID E I | Director | Aug 31, 2020 | Buy | $78.26 | 12,800 | 1,001,715 | 30,740 | Sep 01, 2020, 09:44 PM |
| GREY MICHAEL G | Director | Aug 03, 2020 | Option Exercise | $26.49 | 2,500 | 66,225 | 45,340 | Aug 05, 2020, 06:56 PM |
| GREY MICHAEL G | Director | Aug 03, 2020 | Sale | $120.35 | 2,500 | 300,875 | 42,840 | Aug 05, 2020, 06:56 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jul 20, 2020 | Option Exercise | $65.97 | 126,389 | 8,337,655 | 229,384 | Jul 22, 2020, 05:32 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jul 20, 2020 | Sale | $130.00 | 126,389 | 16,430,570 | 102,995 | Jul 22, 2020, 05:32 PM |
| Acosta Andrea | GVP, Chief Accouning Officer | Jul 17, 2020 | Option Exercise | $128.21 | 285 | 36,540 | 14,674 | Jul 21, 2020, 09:22 PM |
| FUCHS HENRY J | President, Worldwide R&D | Apr 30, 2020 | Option Exercise | $62.59 | 339 | 21,217 | 102,995 | Jul 15, 2020, 09:32 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jul 13, 2020 | Option Exercise | $65.97 | 23,011 | 1,518,094 | 126,006 | Jul 15, 2020, 09:32 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jul 13, 2020 | Sale | $130.00 | 23,011 | 2,991,430 | 102,995 | Jul 15, 2020, 09:32 PM |
| Mueller Brian | EVP, Chief Financial Officer | Apr 30, 2020 | Option Exercise | $62.59 | 323 | 20,215 | 25,104 | Jun 30, 2020, 09:48 PM |
| Dere Willard H | Director | Jun 26, 2020 | Sale | $123.61 | 4,430 | 547,592 | 13,290 | Jun 30, 2020, 02:11 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 30, 2020 | Option Exercise | $62.59 | 338 | 21,154 | 63,402 | Jun 23, 2020, 07:24 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jun 19, 2020 | Option Exercise | $63.10 | 15,000 | 946,500 | 78,402 | Jun 23, 2020, 07:24 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jun 19, 2020 | Sale | $124.00 | 15,000 | 1,860,000 | 63,402 | Jun 23, 2020, 07:24 PM |
| LAWLIS V BRYAN | Director | Jun 05, 2020 | Sale | $107.46 | 4,430 | 476,048 | 18,850 | Jun 09, 2020, 06:04 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 08, 2020 | Option Exercise | $21.51 | 20,000 | 430,200 | 318,552 | May 12, 2020, 01:51 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 08, 2020 | Sale | $91.72 | 20,000 | 1,834,400 | 298,552 | May 12, 2020, 01:51 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 30, 2020 | Option Exercise | $62.59 | 339 | 21,217 | 298,552 | May 05, 2020, 07:22 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 04, 2020 | Option Exercise | $21.51 | 5,000 | 107,550 | 303,552 | May 05, 2020, 07:22 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 01, 2020 | Option Exercise | $21.51 | 4,000 | 86,040 | 302,552 | May 05, 2020, 07:22 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 01, 2020 | Sale | $89.38 | 4,000 | 357,520 | 298,552 | May 05, 2020, 07:22 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 04, 2020 | Sale | $88.00 | 5,000 | 440,000 | 298,552 | May 05, 2020, 07:22 PM |
| Davis George Eric | EVP, General Counsel | Apr 30, 2020 | Option Exercise | $62.59 | 339 | 21,217 | 78,181 | May 04, 2020, 09:45 PM |
| Davis George Eric | EVP, General Counsel | May 01, 2020 | Sale | $89.38 | 12,504 | 1,117,607 | 65,677 | May 04, 2020, 09:45 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 28, 2020 | Option Exercise | $21.51 | 20,000 | 430,200 | 318,213 | Apr 29, 2020, 07:40 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 27, 2020 | Option Exercise | $21.51 | 20,000 | 430,200 | 318,213 | Apr 29, 2020, 07:40 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 28, 2020 | Sale | $97.58 | 20,000 | 1,951,600 | 298,213 | Apr 29, 2020, 07:40 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 27, 2020 | Sale | $97.73 | 20,000 | 1,954,600 | 298,213 | Apr 29, 2020, 07:40 PM |
| FUCHS HENRY J | President, Worldwide R&D | Apr 24, 2020 | Sale | $95.88 | 20,000 | 1,917,617 | 109,014 | Apr 28, 2020, 02:37 PM |
| FUCHS HENRY J | President, Worldwide R&D | Apr 20, 2020 | Sale | $90.00 | 17,213 | 1,549,170 | 122,656 | Apr 22, 2020, 05:15 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 09, 2020 | Option Exercise | $21.51 | 10,000 | 215,100 | 308,213 | Apr 13, 2020, 06:24 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 09, 2020 | Sale | $79.06 | 10,000 | 790,600 | 298,213 | Apr 13, 2020, 06:24 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 08, 2020 | Sale | $79.98 | 2,407 | 192,512 | 63,064 | Apr 09, 2020, 07:58 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 07, 2020 | Option Exercise | $26.49 | 1,000 | 26,490 | 298,213 | Apr 08, 2020, 08:54 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 01, 2020 | Sale | $82.00 | 1,537 | 126,034 | 65,471 | Apr 02, 2020, 08:39 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 25, 2020 | Sale | $78.47 | 1,618 | 126,964 | 67,008 | Mar 26, 2020, 08:34 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 24, 2020 | Sale | $74.36 | 2,041 | 151,769 | 68,626 | Mar 26, 2020, 08:34 PM |
| Mueller Brian | SVP, Acting CFO | Mar 20, 2020 | Option Exercise | $73.05 | 414 | 30,243 | 24,781 | Mar 24, 2020, 09:07 PM |
| BAFFI ROBERT | President, Global Mfg/Tech Ops | Mar 20, 2020 | Option Exercise | $73.05 | 3,501 | 255,748 | 117,138 | Mar 24, 2020, 08:57 PM |
| Davis George Eric | EVP, General Counsel | Mar 20, 2020 | Option Exercise | $73.05 | 3,309 | 241,722 | 77,842 | Mar 24, 2020, 08:53 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 20, 2020 | Option Exercise | $73.05 | 5,836 | 426,320 | 139,869 | Mar 24, 2020, 08:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 20, 2020 | Option Exercise | $73.05 | 13,128 | 959,000 | 297,213 | Mar 24, 2020, 08:42 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 20, 2020 | Option Exercise | $73.05 | 3,599 | 262,907 | 70,667 | Mar 24, 2020, 08:37 PM |
| LAWLIS V BRYAN | Director | Mar 17, 2020 | Option Exercise | $21.51 | 3,750 | 80,663 | 22,730 | Mar 18, 2020, 08:46 PM |
| LAWLIS V BRYAN | Director | Mar 16, 2020 | Sale | $76.52 | 4,610 | 352,757 | 18,980 | Mar 18, 2020, 08:46 PM |
| LAWLIS V BRYAN | Director | Mar 17, 2020 | Sale | $75.39 | 3,750 | 282,712 | 18,980 | Mar 18, 2020, 08:46 PM |
| Mueller Brian | SVP, Acting CFO | Mar 13, 2020 | Option Exercise | $84.50 | 1,303 | 110,104 | 18,465 | Mar 17, 2020, 09:22 PM |
| Davis George Eric | EVP, General Counsel | Mar 13, 2020 | Option Exercise | $84.50 | 7,244 | 612,118 | 71,051 | Mar 17, 2020, 09:19 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 13, 2020 | Option Exercise | $84.50 | 10,496 | 886,912 | 127,485 | Mar 17, 2020, 09:15 PM |
| BAFFI ROBERT | President, Global Mfg/Tech Ops | Mar 13, 2020 | Option Exercise | $84.50 | 7,600 | 642,200 | 109,979 | Mar 17, 2020, 09:11 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 13, 2020 | Option Exercise | $84.50 | 30,952 | 2,615,444 | 265,491 | Mar 17, 2020, 09:08 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 13, 2020 | Option Exercise | $84.50 | 7,644 | 645,918 | 63,886 | Mar 17, 2020, 09:05 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 03, 2020 | Option Exercise | $94.39 | 30 | 2,832 | 296,443 | Mar 11, 2020, 09:01 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 09, 2020 | Option Exercise | $21.51 | 10,000 | 215,100 | 306,443 | Mar 11, 2020, 09:01 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 09, 2020 | Sale | $89.52 | 10,000 | 895,200 | 296,443 | Mar 11, 2020, 09:01 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 03, 2020 | Option Exercise | $21.51 | 10,000 | 215,100 | 338,530 | Feb 05, 2020, 08:38 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 03, 2020 | Sale | $83.50 | 10,000 | 835,000 | 328,530 | Feb 05, 2020, 08:38 PM |
| Mueller Brian | SVP, Acting CFO | Oct 31, 2019 | Option Exercise | $62.23 | 9 | 560 | 13,968 | Feb 04, 2020, 08:19 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 30, 2020 | Option Exercise | $21.51 | 1,000 | 21,510 | 328,530 | Feb 03, 2020, 07:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 14, 2020 | Option Exercise | $21.51 | 8,000 | 172,080 | 335,530 | Jan 16, 2020, 08:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 14, 2020 | Sale | $87.95 | 8,000 | 703,600 | 327,530 | Jan 16, 2020, 08:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 08, 2020 | Option Exercise | $21.51 | 4,000 | 86,040 | 331,530 | Jan 09, 2020, 04:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 07, 2020 | Option Exercise | $21.51 | 3,000 | 64,530 | 330,530 | Jan 09, 2020, 04:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 08, 2020 | Sale | $84.92 | 4,000 | 339,680 | 327,530 | Jan 09, 2020, 04:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 07, 2020 | Sale | $84.46 | 3,000 | 253,380 | 327,530 | Jan 09, 2020, 04:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 27, 2019 | Option Exercise | $21.51 | 5,000 | 107,550 | 332,530 | Dec 30, 2019, 07:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 26, 2019 | Option Exercise | $21.51 | 3,000 | 64,530 | 330,530 | Dec 30, 2019, 07:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 26, 2019 | Sale | $86.43 | 3,000 | 259,290 | 327,530 | Dec 30, 2019, 07:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 27, 2019 | Sale | $86.16 | 5,000 | 430,800 | 327,530 | Dec 30, 2019, 07:27 PM |
| LAWLIS V BRYAN | Director | Dec 17, 2019 | Option Exercise | $21.51 | 3,750 | 80,663 | 27,340 | Dec 19, 2019, 08:09 PM |
| LAWLIS V BRYAN | Director | Dec 17, 2019 | Sale | $83.36 | 3,750 | 312,600 | 23,590 | Dec 19, 2019, 08:09 PM |
| Davis George Eric | EVP, General Counsel | Nov 26, 2019 | Sale | $79.66 | 3,190 | 254,115 | 68,709 | Nov 27, 2019, 06:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 11, 2019 | Option Exercise | $75.38 | 10 | 754 | 327,080 | Nov 26, 2019, 01:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 22, 2019 | Option Exercise | $21.51 | 10,000 | 215,100 | 337,080 | Nov 26, 2019, 01:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 22, 2019 | Sale | $77.60 | 10,000 | 776,000 | 327,080 | Nov 26, 2019, 01:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 25, 2019 | Option Exercise | $21.51 | 5,000 | 107,550 | 332,520 | Oct 29, 2019, 07:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 25, 2019 | Sale | $69.55 | 5,000 | 347,750 | 327,520 | Oct 29, 2019, 07:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 27, 2019 | Option Exercise | $21.51 | 1,000 | 21,510 | 327,520 | Sep 30, 2019, 08:16 PM |
| LAWLIS V BRYAN | Director | Sep 17, 2019 | Option Exercise | $21.51 | 3,750 | 80,663 | 27,340 | Sep 18, 2019, 06:47 PM |
| LAWLIS V BRYAN | Director | Sep 17, 2019 | Sale | $74.47 | 3,750 | 279,263 | 23,590 | Sep 18, 2019, 06:47 PM |
| HERON ELAINE J | Director | Aug 07, 2019 | Option Exercise | $63.10 | 1,553 | 97,994 | 47,668 | Aug 08, 2019, 07:34 PM |
| LAWLIS V BRYAN | Director | Jun 17, 2019 | Option Exercise | $21.51 | 3,750 | 80,663 | 27,340 | Jun 19, 2019, 12:27 PM |
| LAWLIS V BRYAN | Director | Jun 17, 2019 | Sale | $81.08 | 3,750 | 304,050 | 23,590 | Jun 19, 2019, 12:27 PM |
| BAFFI ROBERT | President, Global Mfg/Tech Ops | Apr 30, 2019 | Option Exercise | $68.78 | 309 | 21,254 | 107,727 | Jun 10, 2019, 07:03 PM |
| Davis George Eric | EVP, General Counsel | Apr 30, 2019 | Option Exercise | $68.78 | 309 | 21,254 | 72,199 | Jun 07, 2019, 07:14 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 30, 2019 | Option Exercise | $68.78 | 309 | 21,254 | 61,994 | Jun 07, 2019, 07:08 PM |
| FUCHS HENRY J | President, Worldwide R&D | Apr 30, 2019 | Option Exercise | $68.78 | 309 | 21,254 | 124,845 | Jun 07, 2019, 06:52 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Apr 30, 2019 | Option Exercise | $68.78 | 176 | 12,106 | 47,686 | Jun 07, 2019, 06:51 PM |
| Mueller Brian | SVP, Finance and CAO | Apr 30, 2019 | Option Exercise | $68.78 | 299 | 20,566 | 13,959 | Jun 07, 2019, 06:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 10, 2019 | Option Exercise | $14.39 | 10,000 | 143,900 | 336,520 | May 14, 2019, 07:15 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 10, 2019 | Sale | $82.52 | 10,000 | 825,193 | 326,520 | May 14, 2019, 07:15 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 09, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 330,520 | May 13, 2019, 07:08 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 09, 2019 | Sale | $81.97 | 4,000 | 327,888 | 326,520 | May 13, 2019, 07:08 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 30, 2019 | Option Exercise | $68.78 | 309 | 21,254 | 326,520 | May 09, 2019, 08:32 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 08, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 330,520 | May 09, 2019, 08:32 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 08, 2019 | Sale | $82.16 | 4,000 | 328,625 | 326,520 | May 09, 2019, 08:32 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 26, 2019 | Option Exercise | $14.39 | 3,000 | 43,170 | 329,211 | Apr 30, 2019, 08:09 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 26, 2019 | Sale | $82.88 | 3,000 | 248,640 | 327,211 | Apr 30, 2019, 08:09 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 16, 2019 | Option Exercise | $21.51 | 1,000 | 21,510 | 326,211 | Apr 18, 2019, 07:25 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 12, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 329,211 | Apr 15, 2019, 08:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 11, 2019 | Option Exercise | $14.39 | 1,000 | 14,390 | 325,211 | Apr 15, 2019, 08:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 12, 2019 | Sale | $89.12 | 4,000 | 356,480 | 325,211 | Apr 15, 2019, 08:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 08, 2019 | Option Exercise | $14.39 | 3,000 | 43,170 | 327,211 | Apr 09, 2019, 06:23 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 08, 2019 | Sale | $91.87 | 3,000 | 275,598 | 325,011 | Apr 09, 2019, 06:23 PM |
| Mueller Brian | SVP, Corporate Controller | Apr 05, 2019 | Sale | $94.00 | 2,953 | 277,582 | 13,660 | Apr 09, 2019, 06:12 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 05, 2019 | Option Exercise | $14.39 | 3,000 | 43,170 | 327,211 | Apr 09, 2019, 06:10 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 05, 2019 | Sale | $93.37 | 3,000 | 280,114 | 324,211 | Apr 09, 2019, 06:10 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Apr 01, 2019 | Sale | $89.00 | 13,473 | 1,199,097 | 47,510 | Apr 03, 2019, 01:17 PM |
| LAWLIS V BRYAN | Director | Mar 27, 2019 | Option Exercise | $14.39 | 2,150 | 30,939 | 21,310 | Mar 29, 2019, 06:30 PM |
| LAWLIS V BRYAN | Director | Mar 27, 2019 | Sale | $89.76 | 2,150 | 192,984 | 19,160 | Mar 29, 2019, 06:30 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 27, 2019 | Sale | $90.00 | 100 | 9,000 | 60,983 | Mar 29, 2019, 06:19 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 27, 2019 | Option Exercise | $14.39 | 1,000 | 14,390 | 324,211 | Mar 29, 2019, 06:07 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 26, 2019 | Sale | $89.18 | 3,656 | 326,025 | 47,475 | Mar 27, 2019, 05:59 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 22, 2019 | Option Exercise | $88.05 | 3,598 | 316,804 | 51,131 | Mar 26, 2019, 08:51 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 22, 2019 | Option Exercise | $88.05 | 3,501 | 308,263 | 93,258 | Mar 26, 2019, 08:44 PM |
| Mueller Brian | SVP, Corporate Controller | Mar 22, 2019 | Option Exercise | $88.05 | 415 | 36,541 | 16,613 | Mar 26, 2019, 08:37 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 22, 2019 | Option Exercise | $88.05 | 3,598 | 316,804 | 61,083 | Mar 26, 2019, 08:30 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 22, 2019 | Option Exercise | $88.05 | 5,836 | 513,860 | 130,468 | Mar 26, 2019, 08:20 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 25, 2019 | Sale | $87.86 | 5,932 | 521,186 | 124,536 | Mar 26, 2019, 08:20 PM |
| Davis George Eric | EVP, General Counsel | Mar 22, 2019 | Option Exercise | $88.05 | 3,309 | 291,357 | 75,253 | Mar 26, 2019, 08:01 PM |
| Davis George Eric | EVP, General Counsel | Mar 25, 2019 | Sale | $87.86 | 3,363 | 295,473 | 71,890 | Mar 26, 2019, 08:01 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 22, 2019 | Option Exercise | $88.05 | 13,127 | 1,155,832 | 323,211 | Mar 26, 2019, 07:51 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 25, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 327,211 | Mar 26, 2019, 07:51 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 25, 2019 | Sale | $87.86 | 4,000 | 351,440 | 323,211 | Mar 26, 2019, 07:51 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 21, 2019 | Sale | $89.98 | 4,519 | 406,634 | 56,659 | Mar 25, 2019, 05:18 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 19, 2019 | Option Exercise | $14.39 | 1,000 | 14,390 | 336,338 | Mar 21, 2019, 05:01 PM |
| Davis George Eric | EVP, General Counsel | Mar 19, 2019 | Sale | $93.92 | 7,907 | 742,625 | 78,562 | Mar 21, 2019, 05:00 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 19, 2019 | Sale | $93.07 | 3,728 | 346,965 | 59,248 | Mar 21, 2019, 05:00 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 15, 2019 | Option Exercise | $94.53 | 7,227 | 683,168 | 55,311 | Mar 19, 2019, 08:43 PM |
| Mueller Brian | SVP, Corporate Controller | Mar 15, 2019 | Option Exercise | $94.53 | 1,149 | 108,615 | 11,248 | Mar 19, 2019, 08:26 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 15, 2019 | Option Exercise | $94.53 | 9,443 | 892,647 | 133,061 | Mar 19, 2019, 08:15 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 18, 2019 | Sale | $94.09 | 9,597 | 902,982 | 136,304 | Mar 19, 2019, 08:15 PM |
| Davis George Eric | EVP, General Counsel | Mar 15, 2019 | Option Exercise | $94.53 | 6,648 | 628,435 | 77,099 | Mar 19, 2019, 07:39 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2019 | Option Exercise | $94.53 | 28,143 | 2,660,358 | 300,558 | Mar 19, 2019, 07:21 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 339,338 | Mar 19, 2019, 07:21 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2019 | Sale | $94.40 | 4,000 | 377,600 | 335,338 | Mar 19, 2019, 07:21 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 15, 2019 | Option Exercise | $94.53 | 7,083 | 669,556 | 87,129 | Mar 19, 2019, 06:55 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 15, 2019 | Option Exercise | $94.53 | 7,169 | 677,686 | 53,606 | Mar 19, 2019, 06:41 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 13, 2019 | Option Exercise | $14.39 | 3,000 | 43,170 | 331,701 | Mar 14, 2019, 02:35 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 13, 2019 | Sale | $93.42 | 3,000 | 280,253 | 328,701 | Mar 14, 2019, 02:35 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 12, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 332,701 | Mar 13, 2019, 08:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 11, 2019 | Option Exercise | $14.39 | 5,000 | 71,950 | 333,701 | Mar 13, 2019, 08:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 12, 2019 | Sale | $91.44 | 4,000 | 365,770 | 328,701 | Mar 13, 2019, 08:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 11, 2019 | Sale | $88.96 | 5,000 | 444,780 | 328,701 | Mar 13, 2019, 08:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 07, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 332,701 | Mar 08, 2019, 08:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 07, 2019 | Sale | $90.78 | 4,000 | 363,120 | 328,701 | Mar 08, 2019, 08:34 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 04, 2019 | Sale | $95.00 | 2,196 | 208,620 | 142,504 | Mar 06, 2019, 05:45 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 01, 2019 | Option Exercise | $94.76 | 912 | 86,421 | 62,538 | Mar 05, 2019, 08:08 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 01, 2019 | Option Exercise | $94.76 | 1,154 | 109,353 | 144,700 | Mar 05, 2019, 07:58 PM |
| Davis George Eric | EVP, General Counsel | Mar 01, 2019 | Option Exercise | $94.76 | 840 | 79,598 | 83,747 | Mar 05, 2019, 07:47 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 01, 2019 | Option Exercise | $94.76 | 917 | 86,895 | 60,775 | Mar 05, 2019, 07:37 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 01, 2019 | Option Exercise | $94.76 | 917 | 86,895 | 94,212 | Mar 05, 2019, 07:28 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 01, 2019 | Option Exercise | $94.76 | 4,909 | 465,177 | 328,701 | Mar 05, 2019, 07:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 27, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 292,290 | Feb 28, 2019, 08:24 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 27, 2019 | Sale | $91.78 | 4,000 | 367,120 | 288,290 | Feb 28, 2019, 08:24 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 21, 2019 | Option Exercise | $14.39 | 3,000 | 43,170 | 291,290 | Feb 22, 2019, 06:24 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 21, 2019 | Sale | $90.12 | 3,000 | 270,360 | 288,290 | Feb 22, 2019, 06:24 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 14, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 292,290 | Feb 15, 2019, 07:06 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 14, 2019 | Sale | $95.20 | 4,000 | 380,800 | 288,290 | Feb 15, 2019, 07:06 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 05, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 292,290 | Feb 07, 2019, 07:21 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 05, 2019 | Sale | $98.63 | 4,000 | 394,520 | 288,290 | Feb 07, 2019, 07:21 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 22, 2019 | Option Exercise | $14.39 | 3,000 | 43,170 | 291,290 | Jan 24, 2019, 07:07 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 22, 2019 | Sale | $96.82 | 3,000 | 290,460 | 288,290 | Jan 24, 2019, 07:07 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 14, 2019 | Option Exercise | $14.39 | 4,000 | 57,560 | 292,290 | Jan 15, 2019, 07:43 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 14, 2019 | Sale | $93.79 | 4,000 | 375,160 | 288,290 | Jan 15, 2019, 07:43 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 10, 2019 | Option Exercise | $14.39 | 3,000 | 43,170 | 291,290 | Jan 11, 2019, 03:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 10, 2019 | Sale | $90.55 | 3,000 | 271,650 | 288,290 | Jan 11, 2019, 03:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 08, 2019 | Option Exercise | $14.39 | 6,000 | 86,340 | 294,290 | Jan 10, 2019, 06:50 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 08, 2019 | Sale | $91.59 | 6,000 | 549,523 | 293,290 | Jan 10, 2019, 06:50 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 07, 2019 | Option Exercise | $14.39 | 3,000 | 43,170 | 291,290 | Jan 09, 2019, 02:55 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 07, 2019 | Sale | $87.58 | 3,000 | 262,740 | 288,290 | Jan 09, 2019, 02:55 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 28, 2018 | Option Exercise | $14.39 | 3,000 | 43,170 | 291,290 | Jan 02, 2019, 05:24 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 28, 2018 | Sale | $84.04 | 3,000 | 252,120 | 288,290 | Jan 02, 2019, 05:24 PM |
| LAWLIS V BRYAN | Director | Dec 27, 2018 | Option Exercise | $14.39 | 2,150 | 30,939 | 21,310 | Dec 28, 2018, 06:23 PM |
| LAWLIS V BRYAN | Director | Dec 27, 2018 | Sale | $82.53 | 2,150 | 177,439 | 19,160 | Dec 28, 2018, 06:23 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 26, 2018 | Option Exercise | $14.39 | 4,000 | 57,560 | 292,290 | Dec 27, 2018, 05:35 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 26, 2018 | Sale | $80.50 | 4,000 | 322,000 | 288,290 | Dec 27, 2018, 05:35 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Oct 31, 2018 | Option Exercise | $68.78 | 175 | 12,037 | 51,245 | Dec 20, 2018, 06:06 PM |
| Mueller Brian | SVP, Corporate Controller | Oct 31, 2018 | Option Exercise | $68.78 | 22 | 1,513 | 12,397 | Dec 20, 2018, 05:50 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 14, 2018 | Option Exercise | $17.86 | 2,000 | 35,720 | 290,290 | Dec 18, 2018, 07:58 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 14, 2018 | Sale | $92.64 | 2,000 | 185,280 | 288,290 | Dec 18, 2018, 07:58 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 12, 2018 | Option Exercise | $17.86 | 2,000 | 35,720 | 290,290 | Dec 14, 2018, 02:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 12, 2018 | Sale | $93.12 | 2,000 | 186,240 | 288,290 | Dec 14, 2018, 02:44 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Nov 14, 2018 | Option Exercise | $63.10 | 9,000 | 567,900 | 58,135 | Nov 16, 2018, 07:14 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Nov 14, 2018 | Sale | $92.15 | 9,000 | 829,359 | 52,934 | Nov 16, 2018, 07:14 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 02, 2018 | Option Exercise | $17.86 | 1,500 | 26,790 | 289,790 | Nov 05, 2018, 05:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 02, 2018 | Sale | $97.88 | 1,500 | 146,820 | 288,290 | Nov 05, 2018, 05:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 01, 2018 | Option Exercise | $14.39 | 4,000 | 57,560 | 292,290 | Nov 02, 2018, 05:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 01, 2018 | Sale | $92.55 | 4,000 | 370,200 | 288,290 | Nov 02, 2018, 05:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 30, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 288,290 | Nov 01, 2018, 07:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 24, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 287,290 | Oct 26, 2018, 06:08 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Oct 03, 2018 | Sale | $98.98 | 1,000 | 98,985 | 49,135 | Oct 05, 2018, 06:01 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 03, 2018 | Option Exercise | $17.86 | 1,500 | 26,790 | 287,790 | Oct 05, 2018, 05:42 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 03, 2018 | Sale | $99.36 | 1,500 | 149,040 | 286,290 | Oct 05, 2018, 05:42 PM |
| LAWLIS V BRYAN | Director | Sep 27, 2018 | Option Exercise | $14.39 | 2,150 | 30,939 | 21,310 | Sep 28, 2018, 07:02 PM |
| LAWLIS V BRYAN | Director | Sep 27, 2018 | Sale | $97.93 | 2,150 | 210,550 | 19,160 | Sep 28, 2018, 07:02 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 25, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 286,290 | Sep 27, 2018, 01:58 PM |
| Davis George Eric | EVP, General Counsel | Sep 14, 2018 | Sale | $99.45 | 2,216 | 220,386 | 73,550 | Sep 18, 2018, 04:42 PM |
| MEIER RICHARD A | Director | Sep 13, 2018 | Option Exercise | $21.51 | 15,000 | 322,650 | 84,610 | Sep 17, 2018, 07:22 PM |
| MEIER RICHARD A | Director | Sep 13, 2018 | Sale | $99.24 | 3,000 | 297,722 | 81,810 | Sep 17, 2018, 07:22 PM |
| Davis George Eric | EVP, General Counsel | Sep 13, 2018 | Sale | $99.57 | 12,000 | 1,194,840 | 74,950 | Sep 17, 2018, 06:57 PM |
| HERON ELAINE J | Director | Sep 05, 2018 | Sale | $96.93 | 1,000 | 96,935 | 41,685 | Sep 07, 2018, 02:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 04, 2018 | Option Exercise | $17.86 | 1,500 | 26,790 | 286,790 | Sep 06, 2018, 05:41 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 04, 2018 | Sale | $98.16 | 1,500 | 147,240 | 285,290 | Sep 06, 2018, 05:41 PM |
| LEWIS ALAN | Director | Aug 28, 2018 | Option Exercise | $14.39 | 7,500 | 107,925 | 28,660 | Aug 30, 2018, 01:55 PM |
| LEWIS ALAN | Director | Aug 28, 2018 | Sale | $99.11 | 7,500 | 743,327 | 21,360 | Aug 30, 2018, 01:55 PM |
| MEIER RICHARD A | Director | Aug 27, 2018 | Option Exercise | $14.39 | 15,000 | 215,850 | 71,610 | Aug 29, 2018, 03:51 PM |
| MEIER RICHARD A | Director | Aug 27, 2018 | Sale | $100.12 | 2,000 | 200,236 | 69,610 | Aug 29, 2018, 03:51 PM |
| FUCHS HENRY J | President, Worldwide R&D | Aug 27, 2018 | Sale | $100.00 | 12,500 | 1,250,000 | 130,167 | Aug 28, 2018, 05:54 PM |
| FUCHS HENRY J | President, Worldwide R&D | Aug 24, 2018 | Sale | $99.00 | 12,500 | 1,237,500 | 142,667 | Aug 28, 2018, 05:54 PM |
| LEWIS ALAN | Director | Aug 21, 2018 | Sale | $100.09 | 4,200 | 420,365 | 21,160 | Aug 22, 2018, 07:06 PM |
| BAFFI ROBERT | EVP, Technical Operations | Aug 07, 2018 | Sale | $105.00 | 5,173 | 543,165 | 71,882 | Aug 09, 2018, 04:58 PM |
| Mueller Brian | SVP, Corporate Controller | Aug 07, 2018 | Option Exercise | $28.23 | 2,500 | 70,575 | 14,875 | Aug 09, 2018, 04:27 PM |
| Mueller Brian | SVP, Corporate Controller | Aug 07, 2018 | Sale | $104.50 | 2,500 | 261,250 | 12,375 | Aug 09, 2018, 04:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jul 23, 2018 | Option Exercise | $17.86 | 1,500 | 26,790 | 286,790 | Jul 25, 2018, 07:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jul 23, 2018 | Sale | $101.69 | 1,500 | 152,535 | 285,290 | Jul 25, 2018, 07:47 PM |
| LAWLIS V BRYAN | Director | Jun 27, 2018 | Option Exercise | $14.39 | 2,150 | 30,939 | 21,310 | Jun 29, 2018, 05:59 PM |
| LAWLIS V BRYAN | Director | Jun 27, 2018 | Sale | $93.52 | 2,150 | 201,068 | 19,160 | Jun 29, 2018, 05:59 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Jun 22, 2018 | Sale | $99.00 | 10,000 | 990,005 | 51,542 | Jun 26, 2018, 08:31 PM |
| BAFFI ROBERT | EVP, Technical Operations | Jun 22, 2018 | Option Exercise | $14.39 | 6,949 | 99,996 | 90,225 | Jun 26, 2018, 08:23 PM |
| BAFFI ROBERT | EVP, Technical Operations | Jun 22, 2018 | Sale | $99.00 | 6,949 | 687,954 | 83,604 | Jun 26, 2018, 08:23 PM |
| Mueller Brian | SVP, Corporate Controller | Jun 22, 2018 | Option Exercise | $28.23 | 2,491 | 70,321 | 14,866 | Jun 26, 2018, 08:15 PM |
| Mueller Brian | SVP, Corporate Controller | Jun 22, 2018 | Sale | $99.50 | 3,145 | 312,928 | 12,375 | Jun 26, 2018, 08:15 PM |
| Mueller Brian | SVP, Corporate Controller | Jun 15, 2018 | Sale | $94.50 | 2,021 | 190,985 | 13,029 | Jun 18, 2018, 08:30 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jun 14, 2018 | Option Exercise | $34.43 | 31,000 | 1,067,379 | 175,848 | Jun 18, 2018, 08:11 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jun 14, 2018 | Sale | $90.00 | 31,000 | 2,790,085 | 155,167 | Jun 18, 2018, 08:11 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 13, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 285,290 | Jun 14, 2018, 07:53 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jun 11, 2018 | Sale | $90.31 | 1,436 | 129,685 | 50,135 | Jun 13, 2018, 06:49 PM |
| FUCHS HENRY J | President, Worldwide R&D | Apr 30, 2018 | Option Exercise | $68.78 | 309 | 21,254 | 157,101 | Jun 06, 2018, 08:26 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jun 04, 2018 | Option Exercise | $92.07 | 1,934 | 178,063 | 155,167 | Jun 06, 2018, 08:26 PM |
| Davis George Eric | EVP, General Counsel | Apr 30, 2018 | Option Exercise | $68.78 | 309 | 21,254 | 88,364 | Jun 06, 2018, 08:21 PM |
| Davis George Eric | EVP, General Counsel | Jun 04, 2018 | Option Exercise | $92.07 | 1,414 | 130,187 | 86,950 | Jun 06, 2018, 08:21 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Apr 30, 2018 | Option Exercise | $68.78 | 167 | 11,487 | 62,781 | Jun 06, 2018, 08:15 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Jun 04, 2018 | Option Exercise | $92.07 | 1,711 | 157,532 | 61,070 | Jun 06, 2018, 08:15 PM |
| Mueller Brian | SVP, Corporate Controller | Jun 04, 2018 | Option Exercise | $92.07 | 346 | 31,856 | 15,050 | Jun 06, 2018, 08:09 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jun 04, 2018 | Option Exercise | $92.07 | 1,414 | 130,187 | 51,571 | Jun 06, 2018, 08:05 PM |
| BAFFI ROBERT | EVP, Technical Operations | Apr 30, 2018 | Option Exercise | $68.78 | 309 | 21,254 | 84,838 | Jun 06, 2018, 08:01 PM |
| BAFFI ROBERT | EVP, Technical Operations | Jun 04, 2018 | Option Exercise | $92.07 | 1,562 | 143,813 | 83,276 | Jun 06, 2018, 08:01 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 04, 2018 | Option Exercise | $92.07 | 6,310 | 580,962 | 284,290 | Jun 06, 2018, 07:49 PM |
| MEIER RICHARD A | Director | May 17, 2018 | Option Exercise | $38.59 | 15,000 | 578,850 | 51,310 | May 18, 2018, 06:33 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 17, 2018 | Option Exercise | $38.59 | 18,750 | 723,563 | 309,350 | May 18, 2018, 06:15 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 17, 2018 | Sale | $88.66 | 18,750 | 1,662,356 | 290,600 | May 18, 2018, 06:15 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 16, 2018 | Option Exercise | $38.59 | 18,750 | 723,563 | 309,350 | May 17, 2018, 08:03 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 16, 2018 | Sale | $89.13 | 18,750 | 1,671,131 | 290,600 | May 17, 2018, 08:03 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 14, 2018 | Option Exercise | $38.59 | 18,750 | 723,563 | 309,350 | May 16, 2018, 06:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 15, 2018 | Option Exercise | $38.59 | 18,750 | 723,563 | 309,350 | May 16, 2018, 06:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 15, 2018 | Sale | $88.29 | 18,750 | 1,655,434 | 290,600 | May 16, 2018, 06:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 14, 2018 | Sale | $89.22 | 18,750 | 1,672,851 | 290,600 | May 16, 2018, 06:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 30, 2018 | Option Exercise | $68.78 | 309 | 21,254 | 290,600 | May 14, 2018, 09:28 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 11, 2018 | Option Exercise | $38.59 | 18,750 | 723,563 | 309,350 | May 14, 2018, 09:28 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 10, 2018 | Option Exercise | $38.59 | 18,750 | 723,563 | 309,350 | May 14, 2018, 09:28 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 11, 2018 | Sale | $88.42 | 18,750 | 1,657,856 | 290,600 | May 14, 2018, 09:28 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 10, 2018 | Sale | $89.59 | 18,750 | 1,679,794 | 290,600 | May 14, 2018, 09:28 PM |
| Mueller Brian | SVP, Corporate Controller | Apr 30, 2018 | Option Exercise | $68.78 | 287 | 19,740 | 17,846 | May 14, 2018, 08:43 PM |
| Mueller Brian | SVP, Corporate Controller | May 10, 2018 | Sale | $89.50 | 2,450 | 219,275 | 15,396 | May 14, 2018, 08:43 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 30, 2018 | Option Exercise | $68.78 | 309 | 21,254 | 53,223 | May 09, 2018, 06:41 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 07, 2018 | Sale | $85.96 | 309 | 26,562 | 52,914 | May 09, 2018, 06:41 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 22, 2018 | Option Exercise | $81.36 | 3,598 | 292,733 | 73,587 | Apr 27, 2018, 07:32 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 22, 2018 | Option Exercise | $81.36 | 5,835 | 474,736 | 156,653 | Apr 27, 2018, 07:23 PM |
| Davis George Eric | EVP, General Counsel | Mar 22, 2018 | Option Exercise | $81.36 | 3,308 | 269,139 | 91,326 | Apr 27, 2018, 07:11 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 22, 2018 | Option Exercise | $81.36 | 3,500 | 284,760 | 84,445 | Apr 27, 2018, 06:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 22, 2018 | Option Exercise | $81.36 | 13,127 | 1,068,013 | 283,979 | Apr 27, 2018, 06:31 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 22, 2018 | Option Exercise | $81.36 | 3,598 | 292,733 | 56,555 | Apr 27, 2018, 06:08 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Apr 23, 2018 | Sale | $82.15 | 11,059 | 908,497 | 62,543 | Apr 25, 2018, 08:37 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 24, 2018 | Option Exercise | $38.59 | 10,000 | 385,900 | 300,031 | Apr 25, 2018, 08:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 23, 2018 | Option Exercise | $38.59 | 10,000 | 385,900 | 300,031 | Apr 25, 2018, 08:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 24, 2018 | Sale | $82.29 | 10,000 | 822,887 | 290,031 | Apr 25, 2018, 08:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 23, 2018 | Sale | $82.58 | 10,000 | 825,811 | 290,031 | Apr 25, 2018, 08:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 20, 2018 | Option Exercise | $38.59 | 10,000 | 385,900 | 300,031 | Apr 24, 2018, 07:50 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 20, 2018 | Sale | $83.65 | 10,000 | 836,458 | 290,031 | Apr 24, 2018, 07:50 PM |
| LAWLIS V BRYAN | Director | Apr 17, 2018 | Option Exercise | $38.59 | 3,750 | 144,713 | 18,610 | Apr 19, 2018, 07:19 PM |
| LAWLIS V BRYAN | Director | Apr 17, 2018 | Sale | $85.00 | 3,750 | 318,750 | 14,860 | Apr 19, 2018, 07:19 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 05, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 290,031 | Apr 09, 2018, 03:51 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 02, 2018 | Sale | $80.12 | 2,119 | 169,774 | 52,914 | Apr 03, 2018, 09:00 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 02, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 289,031 | Apr 03, 2018, 08:56 PM |
| FUCHS HENRY J | President, Worldwide R&D | Apr 02, 2018 | Option Exercise | $33.79 | 10,000 | 337,850 | 163,326 | Apr 03, 2018, 08:51 PM |
| FUCHS HENRY J | President, Worldwide R&D | Apr 02, 2018 | Sale | $80.12 | 10,000 | 801,200 | 156,676 | Apr 03, 2018, 08:51 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 29, 2018 | Sale | $79.69 | 1,537 | 122,484 | 55,033 | Mar 30, 2018, 08:03 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 28, 2018 | Option Exercise | $16.13 | 2,000 | 32,250 | 288,031 | Mar 30, 2018, 07:58 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 27, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 286,031 | Mar 28, 2018, 06:36 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 26, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 285,031 | Mar 28, 2018, 06:36 PM |
| Davis George Eric | EVP, General Counsel | Mar 23, 2018 | Sale | $81.35 | 3,350 | 272,522 | 87,989 | Mar 27, 2018, 06:17 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 22, 2018 | Option Exercise | $81.36 | 3,583 | 291,513 | 73,602 | Mar 26, 2018, 08:08 PM |
| Mueller Brian | SVP, Corporate Controller | Mar 22, 2018 | Option Exercise | $81.36 | 414 | 33,683 | 17,559 | Mar 26, 2018, 08:02 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 22, 2018 | Option Exercise | $81.36 | 5,812 | 472,864 | 156,676 | Mar 26, 2018, 07:57 PM |
| Davis George Eric | EVP, General Counsel | Mar 22, 2018 | Option Exercise | $81.36 | 3,295 | 268,081 | 91,339 | Mar 26, 2018, 07:50 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 22, 2018 | Option Exercise | $81.36 | 3,486 | 283,621 | 84,459 | Mar 26, 2018, 07:45 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 22, 2018 | Option Exercise | $81.36 | 3,583 | 291,513 | 56,570 | Mar 26, 2018, 07:36 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 22, 2018 | Option Exercise | $81.36 | 13,075 | 1,063,782 | 284,031 | Mar 26, 2018, 07:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 22, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 297,106 | Mar 26, 2018, 07:27 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 21, 2018 | Sale | $83.90 | 4,368 | 366,475 | 60,153 | Mar 23, 2018, 04:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 16, 2018 | Option Exercise | $38.59 | 15,000 | 578,850 | 311,106 | Mar 20, 2018, 07:46 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 16, 2018 | Sale | $83.26 | 15,000 | 1,248,853 | 296,106 | Mar 20, 2018, 07:46 PM |
| Davis George Eric | EVP, General Counsel | Mar 16, 2018 | Sale | $83.88 | 3,818 | 320,254 | 94,634 | Mar 20, 2018, 07:36 PM |
| Mueller Brian | SVP, Corporate Controller | Mar 15, 2018 | Option Exercise | $83.57 | 309 | 25,823 | 12,609 | Mar 20, 2018, 02:33 PM |
| Mueller Brian | SVP, Corporate Controller | Mar 16, 2018 | Option Exercise | $84.10 | 346 | 29,099 | 12,263 | Mar 20, 2018, 02:33 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2018 | Option Exercise | $83.57 | 14,908 | 1,245,862 | 249,766 | Mar 20, 2018, 02:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2018 | Option Exercise | $38.59 | 15,000 | 578,850 | 279,674 | Mar 20, 2018, 02:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2018 | Sale | $84.73 | 15,000 | 1,270,900 | 264,674 | Mar 20, 2018, 02:16 PM |
| Davis George Eric | EVP, General Counsel | Mar 15, 2018 | Option Exercise | $83.57 | 3,757 | 313,972 | 86,332 | Mar 19, 2018, 09:51 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 15, 2018 | Option Exercise | $83.57 | 4,861 | 406,234 | 146,448 | Mar 19, 2018, 09:50 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 15, 2018 | Option Exercise | $83.57 | 3,644 | 304,529 | 75,825 | Mar 19, 2018, 09:48 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 15, 2018 | Option Exercise | $83.57 | 3,651 | 305,114 | 51,681 | Mar 19, 2018, 09:46 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 15, 2018 | Option Exercise | $83.57 | 3,815 | 318,820 | 64,705 | Mar 19, 2018, 09:45 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 09, 2018 | Sale | $82.39 | 2,972 | 244,863 | 55,332 | Mar 13, 2018, 08:31 PM |
| Davis George Eric | EVP, General Counsel | Mar 05, 2018 | Sale | $79.04 | 2,105 | 166,379 | 90,089 | Mar 07, 2018, 06:06 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 02, 2018 | Option Exercise | $79.86 | 8,542 | 682,164 | 264,674 | Mar 06, 2018, 08:55 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 02, 2018 | Option Exercise | $14.39 | 1,000 | 14,390 | 273,216 | Mar 06, 2018, 08:55 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 02, 2018 | Option Exercise | $79.86 | 1,609 | 128,495 | 68,520 | Mar 06, 2018, 08:48 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 02, 2018 | Option Exercise | $79.86 | 2,576 | 205,719 | 151,309 | Mar 06, 2018, 08:44 PM |
| Davis George Eric | EVP, General Counsel | Mar 02, 2018 | Option Exercise | $79.86 | 2,071 | 165,390 | 92,194 | Mar 06, 2018, 08:39 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 02, 2018 | Option Exercise | $79.86 | 1,615 | 128,974 | 79,469 | Mar 06, 2018, 08:33 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 02, 2018 | Option Exercise | $79.86 | 1,614 | 128,894 | 58,304 | Mar 06, 2018, 08:29 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 15, 2018 | Option Exercise | $38.59 | 10,000 | 385,900 | 236,494 | Feb 20, 2018, 08:40 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 15, 2018 | Sale | $84.63 | 10,000 | 846,285 | 226,494 | Feb 20, 2018, 08:40 PM |
| Davis George Eric | EVP, General Counsel | Feb 01, 2018 | Option Exercise | $38.59 | 30,000 | 1,157,700 | 112,942 | Feb 05, 2018, 08:13 PM |
| Davis George Eric | EVP, General Counsel | Feb 01, 2018 | Sale | $90.66 | 30,000 | 2,719,665 | 82,942 | Feb 05, 2018, 08:13 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 05, 2018 | Option Exercise | $38.59 | 10,000 | 385,900 | 235,894 | Jan 09, 2018, 08:36 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 05, 2018 | Sale | $90.32 | 10,000 | 903,203 | 225,894 | Jan 09, 2018, 08:36 PM |
| LAWLIS V BRYAN | Director | Jan 02, 2018 | Option Exercise | $38.59 | 3,750 | 144,713 | 18,610 | Jan 04, 2018, 08:16 PM |
| LAWLIS V BRYAN | Director | Jan 02, 2018 | Sale | $88.84 | 3,750 | 333,150 | 14,860 | Jan 04, 2018, 08:16 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jan 02, 2018 | Option Exercise | $33.80 | 15,000 | 507,050 | 148,976 | Jan 04, 2018, 07:26 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jan 02, 2018 | Sale | $89.23 | 15,000 | 1,338,400 | 133,976 | Jan 04, 2018, 07:26 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 29, 2017 | Option Exercise | $38.59 | 10,000 | 385,900 | 235,894 | Jan 02, 2018, 05:29 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 28, 2017 | Option Exercise | $38.59 | 10,000 | 385,900 | 235,894 | Jan 02, 2018, 05:29 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 29, 2017 | Sale | $89.61 | 10,000 | 896,125 | 225,894 | Jan 02, 2018, 05:29 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 28, 2017 | Sale | $89.89 | 10,000 | 898,912 | 225,894 | Jan 02, 2018, 05:29 PM |
| HERON ELAINE J | Director | Dec 14, 2017 | Sale | $88.89 | 800 | 71,116 | 38,385 | Dec 18, 2017, 08:56 PM |
| Davis George Eric | EVP, General Counsel | Nov 30, 2017 | Sale | $85.64 | 1,200 | 102,767 | 82,942 | Dec 04, 2017, 08:26 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | May 27, 2015 | Option Exercise | $67.81 | 34,078 | 2,310,829 | 109,663 | Oct 13, 2017, 08:43 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | May 27, 2015 | Sale | $130.00 | 34,078 | 4,430,140 | 75,585 | Oct 13, 2017, 08:43 PM |
| BAFFI ROBERT | EVP, Technical Operations | Sep 28, 2017 | Sale | $92.50 | 15,500 | 1,433,676 | 129,083 | Oct 02, 2017, 09:07 PM |
| BAFFI ROBERT | EVP, Technical Operations | Sep 28, 2017 | Sale | $92.06 | 2,915 | 268,355 | 28,761 | Oct 02, 2017, 09:07 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Sep 22, 2017 | Option Exercise | $37.46 | 3,521 | 131,897 | 50,110 | Sep 26, 2017, 07:19 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Sep 22, 2017 | Sale | $95.00 | 3,521 | 334,495 | 47,944 | Sep 26, 2017, 07:19 PM |
| LAWLIS V BRYAN | Director | Sep 15, 2017 | Option Exercise | $38.59 | 3,750 | 144,713 | 19,660 | Sep 19, 2017, 03:27 PM |
| LAWLIS V BRYAN | Director | Sep 15, 2017 | Sale | $91.26 | 3,750 | 342,225 | 15,910 | Sep 19, 2017, 03:27 PM |
| FUCHS HENRY J | President, Worldwide R&D | Sep 15, 2017 | Option Exercise | $33.80 | 15,000 | 507,050 | 151,422 | Sep 19, 2017, 03:17 PM |
| FUCHS HENRY J | President, Worldwide R&D | Sep 15, 2017 | Sale | $90.50 | 15,000 | 1,357,500 | 136,422 | Sep 19, 2017, 03:17 PM |
| Davis George Eric | EVP, General Counsel | Jun 23, 2017 | Option Exercise | $38.59 | 9,844 | 379,880 | 93,425 | Jun 27, 2017, 08:46 PM |
| Davis George Eric | EVP, General Counsel | Jun 23, 2017 | Sale | $96.60 | 9,844 | 950,930 | 83,581 | Jun 27, 2017, 08:46 PM |
| Mueller Brian | SVP, Corporate Controller | Jun 22, 2017 | Option Exercise | $21.51 | 2,671 | 57,453 | 15,556 | Jun 23, 2017, 05:39 PM |
| Mueller Brian | SVP, Corporate Controller | Jun 22, 2017 | Sale | $100.00 | 2,671 | 267,100 | 12,885 | Jun 23, 2017, 05:39 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jun 19, 2017 | Option Exercise | $37.46 | 603 | 22,588 | 137,025 | Jun 20, 2017, 06:33 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jun 16, 2017 | Option Exercise | $33.65 | 14,397 | 484,462 | 150,819 | Jun 20, 2017, 06:33 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jun 19, 2017 | Sale | $90.00 | 603 | 54,270 | 136,422 | Jun 20, 2017, 06:33 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jun 16, 2017 | Sale | $90.00 | 14,397 | 1,295,730 | 145,819 | Jun 20, 2017, 06:33 PM |
| LAWLIS V BRYAN | Director | Jun 16, 2017 | Option Exercise | $38.59 | 3,750 | 144,713 | 19,660 | Jun 20, 2017, 06:31 PM |
| LAWLIS V BRYAN | Director | Jun 16, 2017 | Sale | $90.00 | 3,750 | 337,500 | 15,910 | Jun 20, 2017, 06:31 PM |
| Davis George Eric | EVP, General Counsel | Jun 09, 2017 | Option Exercise | $23.54 | 9,239 | 217,530 | 83,581 | Jun 13, 2017, 08:56 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jun 07, 2017 | Sale | $89.61 | 1,004 | 89,968 | 47,944 | Jun 09, 2017, 06:31 PM |
| Davis George Eric | EVP, General Counsel | Jun 05, 2017 | Sale | $91.04 | 9,471 | 862,230 | 74,342 | Jun 07, 2017, 08:26 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Jun 02, 2017 | Option Exercise | $90.72 | 1,801 | 163,387 | 23,303 | Jun 06, 2017, 09:07 PM |
| Mueller Brian | SVP, Corporate Controller | Jun 02, 2017 | Option Exercise | $90.72 | 376 | 34,111 | 12,885 | Jun 06, 2017, 09:02 PM |
| FUCHS HENRY J | President, Worldwide R&D | Jun 02, 2017 | Option Exercise | $90.72 | 2,036 | 184,706 | 136,422 | Jun 06, 2017, 08:57 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jun 02, 2017 | Option Exercise | $90.72 | 1,488 | 134,991 | 48,948 | Jun 06, 2017, 08:50 PM |
| BAFFI ROBERT | EVP, Technical Operations | Jun 02, 2017 | Option Exercise | $90.72 | 1,644 | 149,144 | 144,583 | Jun 06, 2017, 08:45 PM |
| Davis George Eric | EVP, General Counsel | Jun 02, 2017 | Option Exercise | $90.72 | 1,488 | 134,991 | 83,813 | Jun 06, 2017, 08:39 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 02, 2017 | Option Exercise | $90.72 | 6,640 | 602,381 | 226,924 | Jun 06, 2017, 08:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 02, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 238,564 | Jun 06, 2017, 08:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 05, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 231,924 | Jun 06, 2017, 08:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 02, 2017 | Sale | $89.70 | 5,000 | 448,500 | 233,564 | Jun 06, 2017, 08:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 05, 2017 | Sale | $90.56 | 5,000 | 452,800 | 226,924 | Jun 06, 2017, 08:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 01, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 238,564 | Jun 05, 2017, 07:05 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 01, 2017 | Sale | $87.53 | 5,000 | 437,650 | 233,564 | Jun 05, 2017, 07:05 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 31, 2017 | Option Exercise | $17.33 | 7,423 | 128,641 | 240,987 | Jun 02, 2017, 05:52 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 31, 2017 | Sale | $88.29 | 7,423 | 655,377 | 233,564 | Jun 02, 2017, 05:52 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 24, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 238,564 | May 26, 2017, 05:02 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 24, 2017 | Sale | $88.38 | 5,000 | 441,900 | 233,564 | May 26, 2017, 05:02 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 17, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 238,564 | May 19, 2017, 10:33 AM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 17, 2017 | Sale | $91.73 | 5,000 | 458,650 | 233,564 | May 19, 2017, 10:33 AM |
| Davis George Eric | EVP, General Counsel | May 15, 2017 | Option Exercise | $91.50 | 1,096 | 100,284 | 84,155 | May 17, 2017, 06:55 PM |
| Davis George Eric | EVP, General Counsel | May 16, 2017 | Option Exercise | $14.39 | 1,146 | 16,491 | 85,301 | May 17, 2017, 06:55 PM |
| Mueller Brian | SVP, Corporate Controller | May 15, 2017 | Option Exercise | $91.50 | 207 | 18,941 | 13,261 | May 17, 2017, 06:53 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 15, 2017 | Option Exercise | $91.50 | 4,932 | 451,278 | 233,564 | May 17, 2017, 06:51 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Apr 28, 2017 | Option Exercise | $70.30 | 155 | 10,897 | 26,826 | May 17, 2017, 06:50 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | May 15, 2017 | Option Exercise | $91.50 | 1,722 | 157,563 | 25,104 | May 17, 2017, 06:50 PM |
| FUCHS HENRY J | President, Worldwide R&D | Apr 28, 2017 | Option Exercise | $70.30 | 302 | 21,232 | 140,494 | May 17, 2017, 06:48 PM |
| FUCHS HENRY J | President, Worldwide R&D | May 15, 2017 | Option Exercise | $91.50 | 2,036 | 186,294 | 138,458 | May 17, 2017, 06:48 PM |
| BAFFI ROBERT | EVP, Technical Operations | Apr 28, 2017 | Option Exercise | $70.30 | 302 | 21,232 | 147,793 | May 17, 2017, 06:46 PM |
| BAFFI ROBERT | EVP, Technical Operations | May 15, 2017 | Option Exercise | $91.50 | 1,566 | 143,289 | 146,227 | May 17, 2017, 06:46 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 15, 2017 | Option Exercise | $91.50 | 1,096 | 100,284 | 50,436 | May 17, 2017, 06:42 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 12, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 243,496 | May 16, 2017, 06:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 12, 2017 | Sale | $89.23 | 5,000 | 446,150 | 238,496 | May 16, 2017, 06:47 PM |
| Mueller Brian | SVP, Corporate Controller | Apr 28, 2017 | Option Exercise | $70.30 | 270 | 18,982 | 18,350 | May 10, 2017, 03:23 PM |
| Mueller Brian | SVP, Corporate Controller | May 08, 2017 | Option Exercise | $21.51 | 2,600 | 55,926 | 16,068 | May 10, 2017, 03:23 PM |
| Mueller Brian | SVP, Corporate Controller | May 08, 2017 | Sale | $91.86 | 7,482 | 687,334 | 13,468 | May 10, 2017, 03:23 PM |
| MEIER RICHARD A | Director | May 05, 2017 | Option Exercise | $17.33 | 7,500 | 129,975 | 34,260 | May 09, 2017, 01:24 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 05, 2017 | Option Exercise | $36.31 | 4,486 | 162,879 | 55,030 | May 09, 2017, 01:23 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 05, 2017 | Sale | $99.00 | 4,486 | 444,114 | 51,532 | May 09, 2017, 01:23 PM |
| Davis George Eric | EVP, General Counsel | Apr 28, 2017 | Option Exercise | $70.30 | 302 | 21,232 | 85,251 | May 09, 2017, 01:21 PM |
| Davis George Eric | EVP, General Counsel | May 05, 2017 | Option Exercise | $38.59 | 2,500 | 96,475 | 87,751 | May 09, 2017, 01:21 PM |
| Davis George Eric | EVP, General Counsel | May 05, 2017 | Sale | $100.34 | 2,500 | 250,853 | 85,251 | May 09, 2017, 01:21 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 28, 2017 | Option Exercise | $70.30 | 302 | 21,232 | 238,496 | May 09, 2017, 01:19 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 08, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 243,496 | May 09, 2017, 01:19 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 243,496 | May 09, 2017, 01:19 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 08, 2017 | Sale | $93.17 | 5,000 | 465,850 | 238,496 | May 09, 2017, 01:19 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2017 | Sale | $99.00 | 5,000 | 495,000 | 238,496 | May 09, 2017, 01:19 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 28, 2017 | Option Exercise | $70.30 | 302 | 21,232 | 51,834 | May 04, 2017, 08:54 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 02, 2017 | Sale | $96.74 | 302 | 29,215 | 51,532 | May 04, 2017, 08:54 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 27, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 243,194 | May 01, 2017, 05:39 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 27, 2017 | Sale | $95.72 | 5,000 | 478,600 | 238,194 | May 01, 2017, 05:39 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 25, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 243,194 | Apr 27, 2017, 06:49 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 25, 2017 | Sale | $94.00 | 5,000 | 470,000 | 238,194 | Apr 27, 2017, 06:49 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 04, 2017 | Option Exercise | $14.39 | 3,000 | 43,170 | 238,194 | Apr 06, 2017, 05:28 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 29, 2017 | Sale | $89.15 | 3,890 | 346,794 | 51,532 | Mar 31, 2017, 05:34 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 15, 2017 | Option Exercise | $92.50 | 3,288 | 304,140 | 43,222 | Mar 17, 2017, 06:36 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 15, 2017 | Option Exercise | $92.50 | 5,116 | 473,230 | 120,402 | Mar 17, 2017, 06:35 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 15, 2017 | Option Exercise | $92.50 | 3,289 | 304,233 | 135,621 | Mar 17, 2017, 06:34 PM |
| Mueller Brian | SVP, Corporate Controller | Mar 16, 2017 | Option Exercise | $90.96 | 376 | 34,201 | 13,290 | Mar 17, 2017, 06:32 PM |
| Mueller Brian | SVP, Corporate Controller | Mar 15, 2017 | Option Exercise | $92.50 | 336 | 31,080 | 13,666 | Mar 17, 2017, 06:32 PM |
| Davis George Eric | EVP, General Counsel | Mar 15, 2017 | Option Exercise | $92.50 | 2,995 | 277,038 | 75,967 | Mar 17, 2017, 06:31 PM |
| Davis George Eric | EVP, General Counsel | Mar 16, 2017 | Sale | $91.96 | 2,238 | 205,806 | 73,729 | Mar 17, 2017, 06:31 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 15, 2017 | Option Exercise | $92.50 | 4,301 | 397,843 | 16,460 | Mar 17, 2017, 06:30 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 16, 2017 | Sale | $91.96 | 1,989 | 182,908 | 14,471 | Mar 17, 2017, 06:30 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2017 | Option Exercise | $92.50 | 15,690 | 1,451,325 | 190,674 | Mar 17, 2017, 06:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 211,364 | Mar 17, 2017, 06:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 16, 2017 | Option Exercise | $71.33 | 5,000 | 356,650 | 195,674 | Mar 17, 2017, 06:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 16, 2017 | Sale | $91.96 | 5,000 | 459,800 | 190,674 | Mar 17, 2017, 06:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 15, 2017 | Sale | $91.42 | 5,000 | 457,100 | 206,364 | Mar 17, 2017, 06:27 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 13, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 211,364 | Mar 15, 2017, 07:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 13, 2017 | Sale | $92.68 | 5,000 | 463,400 | 206,364 | Mar 15, 2017, 07:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 09, 2017 | Option Exercise | $17.33 | 6,000 | 103,980 | 212,364 | Mar 13, 2017, 07:59 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 10, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 211,364 | Mar 13, 2017, 07:59 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 10, 2017 | Sale | $91.09 | 5,000 | 455,450 | 206,364 | Mar 13, 2017, 07:59 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 09, 2017 | Sale | $90.18 | 6,000 | 541,080 | 206,364 | Mar 13, 2017, 07:59 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 07, 2017 | Sale | $90.56 | 5,000 | 452,800 | 46,510 | Mar 08, 2017, 07:31 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 06, 2017 | Sale | $93.32 | 2,303 | 214,916 | 20,761 | Mar 08, 2017, 07:28 PM |
| Davis George Eric | EVP, General Counsel | Mar 06, 2017 | Sale | $93.32 | 1,498 | 139,793 | 78,962 | Mar 08, 2017, 07:24 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Mar 03, 2017 | Option Exercise | $93.95 | 1,749 | 164,319 | 51,510 | Mar 07, 2017, 06:44 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 03, 2017 | Option Exercise | $93.95 | 1,749 | 164,319 | 138,910 | Mar 07, 2017, 06:42 PM |
| Davis George Eric | EVP, General Counsel | Mar 03, 2017 | Option Exercise | $93.95 | 1,596 | 149,944 | 80,460 | Mar 07, 2017, 06:40 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 03, 2017 | Option Exercise | $93.95 | 2,283 | 214,488 | 23,064 | Mar 07, 2017, 06:38 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 03, 2017 | Option Exercise | $93.95 | 8,989 | 844,517 | 206,364 | Mar 07, 2017, 06:37 PM |
| FUCHS HENRY J | President, Worldwide R&D | Mar 03, 2017 | Option Exercise | $93.95 | 2,924 | 274,710 | 125,518 | Mar 07, 2017, 06:34 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Feb 28, 2017 | Option Exercise | $63.10 | 30,000 | 1,893,000 | 60,347 | Mar 02, 2017, 06:20 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 01, 2017 | Sale | $94.50 | 5,000 | 472,500 | 25,347 | Mar 02, 2017, 06:20 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Feb 28, 2017 | Sale | $94.00 | 30,000 | 2,820,000 | 30,347 | Mar 02, 2017, 06:20 PM |
| LAWLIS V BRYAN | Director | Mar 01, 2017 | Option Exercise | $17.33 | 7,500 | 129,975 | 21,360 | Mar 02, 2017, 06:14 PM |
| LAWLIS V BRYAN | Director | Mar 01, 2017 | Sale | $95.00 | 7,500 | 712,500 | 13,860 | Mar 02, 2017, 06:14 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Feb 24, 2017 | Option Exercise | $95.61 | 11,917 | 1,139,396 | 53,259 | Feb 28, 2017, 04:39 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 26, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 175,682 | Jan 27, 2017, 05:46 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 25, 2017 | Option Exercise | $17.33 | 5,000 | 86,650 | 175,682 | Jan 27, 2017, 05:46 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 26, 2017 | Sale | $84.00 | 5,000 | 420,000 | 170,682 | Jan 27, 2017, 05:46 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 25, 2017 | Sale | $84.44 | 5,000 | 422,200 | 170,682 | Jan 27, 2017, 05:46 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 11, 2017 | Option Exercise | $17.33 | 4,000 | 69,320 | 174,682 | Jan 12, 2017, 06:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 10, 2017 | Option Exercise | $17.33 | 4,000 | 69,320 | 174,682 | Jan 12, 2017, 06:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 10, 2017 | Sale | $91.31 | 4,000 | 365,240 | 170,682 | Jan 12, 2017, 06:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 11, 2017 | Sale | $89.84 | 4,000 | 359,360 | 170,682 | Jan 12, 2017, 06:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 06, 2017 | Option Exercise | $17.33 | 4,000 | 69,320 | 174,682 | Jan 10, 2017, 04:53 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 09, 2017 | Option Exercise | $17.33 | 4,000 | 69,320 | 174,682 | Jan 10, 2017, 04:53 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 06, 2017 | Sale | $87.19 | 4,000 | 348,760 | 170,682 | Jan 10, 2017, 04:53 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jan 09, 2017 | Sale | $89.79 | 4,000 | 359,160 | 170,682 | Jan 10, 2017, 04:53 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Jan 09, 2017 | Sale | $90.00 | 5,000 | 450,000 | 18,100 | Jan 10, 2017, 04:50 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 29, 2016 | Option Exercise | $17.33 | 4,000 | 69,320 | 174,682 | Jan 03, 2017, 05:46 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 30, 2016 | Option Exercise | $17.33 | 4,000 | 69,320 | 174,682 | Jan 03, 2017, 05:46 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 30, 2016 | Sale | $83.35 | 4,000 | 333,400 | 170,682 | Jan 03, 2017, 05:46 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Dec 29, 2016 | Sale | $83.84 | 4,000 | 335,360 | 170,682 | Jan 03, 2017, 05:46 PM |
| FUCHS HENRY J | President, Worldwide R&D | Nov 25, 2016 | Option Exercise | $26.49 | 15,000 | 397,350 | 128,878 | Nov 29, 2016, 08:34 PM |
| FUCHS HENRY J | President, Worldwide R&D | Nov 25, 2016 | Sale | $87.40 | 15,000 | 1,310,988 | 113,878 | Nov 29, 2016, 08:34 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 21, 2016 | Option Exercise | $26.49 | 69,744 | 1,847,519 | 240,426 | Nov 23, 2016, 04:42 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 22, 2016 | Option Exercise | $26.49 | 69,743 | 1,847,492 | 240,425 | Nov 23, 2016, 04:42 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 21, 2016 | Sale | $87.56 | 69,744 | 6,106,478 | 170,682 | Nov 23, 2016, 04:42 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 22, 2016 | Sale | $85.69 | 69,743 | 5,976,515 | 170,682 | Nov 23, 2016, 04:42 PM |
| Davis George Eric | EVP, General Counsel | Nov 18, 2016 | Option Exercise | $38.59 | 5,000 | 192,950 | 75,798 | Nov 22, 2016, 07:13 PM |
| Davis George Eric | EVP, General Counsel | Nov 18, 2016 | Sale | $90.42 | 5,000 | 452,100 | 70,798 | Nov 22, 2016, 07:13 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 16, 2016 | Option Exercise | $17.54 | 41,670 | 730,892 | 365,038 | Nov 18, 2016, 05:37 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 16, 2016 | Sale | $90.97 | 41,670 | 3,790,795 | 323,368 | Nov 18, 2016, 05:37 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Oct 31, 2016 | Option Exercise | $68.44 | 156 | 10,677 | 43,100 | Nov 14, 2016, 02:02 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Nov 09, 2016 | Sale | $90.61 | 20,000 | 1,812,206 | 23,100 | Nov 14, 2016, 02:02 PM |
| LAWLIS V BRYAN | Director | Nov 09, 2016 | Option Exercise | $17.33 | 7,500 | 129,975 | 21,360 | Nov 14, 2016, 01:59 PM |
| LAWLIS V BRYAN | Director | Nov 09, 2016 | Sale | $95.00 | 7,500 | 712,500 | 13,860 | Nov 14, 2016, 01:59 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 08, 2016 | Option Exercise | $21.51 | 70,000 | 1,505,700 | 393,368 | Nov 09, 2016, 08:23 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 07, 2016 | Option Exercise | $21.51 | 70,000 | 1,505,700 | 393,368 | Nov 09, 2016, 08:23 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 07, 2016 | Sale | $82.52 | 70,000 | 5,776,435 | 323,368 | Nov 09, 2016, 08:23 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 08, 2016 | Sale | $82.83 | 70,000 | 5,797,806 | 323,368 | Nov 09, 2016, 08:23 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 27, 2016 | Option Exercise | $14.39 | 60,000 | 863,400 | 383,368 | Oct 31, 2016, 07:33 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 28, 2016 | Option Exercise | $14.39 | 60,000 | 863,400 | 383,368 | Oct 31, 2016, 07:33 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 27, 2016 | Sale | $81.34 | 60,000 | 4,880,448 | 323,368 | Oct 31, 2016, 07:33 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 28, 2016 | Sale | $81.27 | 60,000 | 4,875,990 | 323,368 | Oct 31, 2016, 07:33 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 17, 2016 | Option Exercise | $17.54 | 41,666 | 730,822 | 365,034 | Oct 19, 2016, 04:41 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 17, 2016 | Sale | $84.39 | 41,666 | 3,516,227 | 323,368 | Oct 19, 2016, 04:41 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 14, 2016 | Option Exercise | $17.86 | 11,000 | 196,460 | 334,368 | Oct 17, 2016, 07:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 13, 2016 | Option Exercise | $38.59 | 53,125 | 2,050,094 | 376,493 | Oct 17, 2016, 07:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 13, 2016 | Sale | $86.98 | 53,125 | 4,620,563 | 323,368 | Oct 17, 2016, 07:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 14, 2016 | Sale | $86.89 | 11,000 | 955,814 | 323,368 | Oct 17, 2016, 07:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 30, 2016 | Option Exercise | $38.59 | 53,125 | 2,050,094 | 431,709 | Oct 04, 2016, 03:59 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 30, 2016 | Sale | $92.02 | 53,125 | 4,888,780 | 378,584 | Oct 04, 2016, 03:59 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 29, 2016 | Option Exercise | $38.59 | 53,125 | 2,050,094 | 431,709 | Oct 03, 2016, 06:37 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 29, 2016 | Sale | $93.65 | 53,125 | 4,974,901 | 378,584 | Oct 03, 2016, 06:37 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Sep 27, 2016 | Sale | $95.61 | 18,467 | 1,765,648 | 41,342 | Sep 29, 2016, 07:21 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 15, 2016 | Option Exercise | $17.33 | 42,577 | 737,859 | 421,161 | Sep 19, 2016, 06:41 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 16, 2016 | Option Exercise | $29.34 | 94,791 | 2,780,915 | 431,709 | Sep 19, 2016, 06:41 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 16, 2016 | Sale | $95.56 | 94,791 | 9,058,601 | 378,584 | Sep 19, 2016, 06:41 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 15, 2016 | Sale | $94.85 | 42,577 | 4,038,360 | 378,584 | Sep 19, 2016, 06:41 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | Aug 26, 2016 | Option Exercise | $26.49 | 15,000 | 397,350 | 128,878 | Aug 30, 2016, 09:07 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | Aug 26, 2016 | Sale | $95.06 | 15,000 | 1,425,924 | 113,878 | Aug 30, 2016, 09:07 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Aug 16, 2016 | Option Exercise | $17.54 | 41,666 | 730,822 | 420,250 | Aug 17, 2016, 04:37 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Aug 16, 2016 | Sale | $91.49 | 41,666 | 3,811,868 | 378,584 | Aug 17, 2016, 04:37 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Aug 01, 2016 | Sale | $99.33 | 4,000 | 397,320 | 42,944 | Aug 03, 2016, 10:19 AM |
| Davis George Eric | EVP, General Counsel | Aug 01, 2016 | Sale | $100.00 | 2,167 | 216,700 | 71,158 | Aug 03, 2016, 10:13 AM |
| Mueller Brian | VP, Corporate Controller | Aug 01, 2016 | Sale | $100.00 | 287 | 28,700 | 14,260 | Aug 03, 2016, 10:12 AM |
| LAWLIS V BRYAN | Director | Jul 27, 2016 | Option Exercise | $17.33 | 1,100 | 19,063 | 14,960 | Jul 28, 2016, 07:02 PM |
| LAWLIS V BRYAN | Director | Jul 27, 2016 | Sale | $95.39 | 1,100 | 104,927 | 13,860 | Jul 28, 2016, 07:02 PM |
| LAWLIS V BRYAN | Director | Jul 22, 2016 | Option Exercise | $17.33 | 6,400 | 110,912 | 20,260 | Jul 26, 2016, 06:57 PM |
| LAWLIS V BRYAN | Director | Jul 22, 2016 | Sale | $95.01 | 6,400 | 608,064 | 13,860 | Jul 26, 2016, 06:57 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jul 18, 2016 | Option Exercise | $17.54 | 41,666 | 730,822 | 420,250 | Jul 20, 2016, 07:51 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jul 18, 2016 | Sale | $92.72 | 41,666 | 3,863,272 | 378,584 | Jul 20, 2016, 07:51 PM |
| Davis George Eric | EVP, General Counsel | Jul 14, 2016 | Option Exercise | $38.59 | 2,656 | 102,495 | 73,325 | Jul 18, 2016, 06:02 PM |
| Davis George Eric | EVP, General Counsel | Jul 07, 2016 | Sale | $90.00 | 2,167 | 195,030 | 70,669 | Jul 11, 2016, 04:45 PM |
| LAWLIS V BRYAN | Director | Jun 20, 2016 | Sale | $82.77 | 550 | 45,523 | 13,860 | Jun 21, 2016, 04:58 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 16, 2016 | Option Exercise | $17.54 | 41,666 | 730,822 | 420,250 | Jun 20, 2016, 08:23 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 16, 2016 | Sale | $80.55 | 41,666 | 3,356,196 | 378,584 | Jun 20, 2016, 08:23 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Jun 06, 2016 | Sale | $89.14 | 1,649 | 146,992 | 46,944 | Jun 08, 2016, 08:39 PM |
| BAFFI ROBERT | EVP, Technical Operations | Jun 03, 2016 | Option Exercise | $90.00 | 1,644 | 147,960 | 128,742 | Jun 07, 2016, 11:10 AM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Jun 03, 2016 | Option Exercise | $90.00 | 1,488 | 133,920 | 59,809 | Jun 07, 2016, 11:07 AM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 03, 2016 | Option Exercise | $90.00 | 6,640 | 597,600 | 378,584 | Jun 07, 2016, 11:06 AM |
| FUCHS HENRY J | EVP, Chief Medical Officer | Jun 03, 2016 | Option Exercise | $90.00 | 2,036 | 183,240 | 113,878 | Jun 07, 2016, 11:04 AM |
| Davis George Eric | EVP, General Counsel | Jun 03, 2016 | Option Exercise | $90.00 | 1,488 | 133,920 | 72,956 | Jun 07, 2016, 11:02 AM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Jun 03, 2016 | Option Exercise | $90.00 | 1,801 | 162,090 | 48,593 | Jun 07, 2016, 11:00 AM |
| Mueller Brian | VP, Corporate Controller | Jun 03, 2016 | Option Exercise | $90.00 | 376 | 33,840 | 14,547 | Jun 07, 2016, 10:58 AM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | May 31, 2016 | Option Exercise | $39.06 | 16,896 | 659,958 | 71,235 | Jun 02, 2016, 06:21 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | May 31, 2016 | Sale | $89.88 | 20,841 | 1,873,126 | 54,339 | Jun 02, 2016, 06:21 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | May 27, 2016 | Option Exercise | $89.09 | 4,305 | 383,532 | 54,339 | May 31, 2016, 06:56 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | May 26, 2016 | Option Exercise | $26.49 | 15,000 | 397,350 | 130,914 | May 31, 2016, 06:52 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | May 26, 2016 | Sale | $87.81 | 15,000 | 1,317,100 | 120,914 | May 31, 2016, 06:52 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | May 23, 2016 | Sale | $87.07 | 3,769 | 328,184 | 58,644 | May 25, 2016, 02:57 PM |
| BAFFI ROBERT | EVP, Technical Operations | May 18, 2016 | Sale | $87.05 | 5,000 | 435,248 | 130,386 | May 19, 2016, 03:53 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Apr 29, 2016 | Option Exercise | $51.26 | 202 | 10,355 | 64,135 | May 17, 2016, 03:12 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | May 13, 2016 | Option Exercise | $82.71 | 1,722 | 142,427 | 62,413 | May 17, 2016, 03:12 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 13, 2016 | Option Exercise | $82.71 | 4,932 | 407,926 | 385,224 | May 17, 2016, 03:11 PM |
| Davis George Eric | EVP, General Counsel | May 13, 2016 | Option Exercise | $82.71 | 1,096 | 90,650 | 74,444 | May 17, 2016, 03:09 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | May 13, 2016 | Option Exercise | $82.71 | 2,036 | 168,398 | 115,914 | May 17, 2016, 03:08 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 13, 2016 | Option Exercise | $82.71 | 1,096 | 90,650 | 61,297 | May 17, 2016, 03:05 PM |
| BAFFI ROBERT | EVP, Technical Operations | May 13, 2016 | Option Exercise | $82.71 | 1,566 | 129,524 | 135,386 | May 17, 2016, 03:03 PM |
| Mueller Brian | VP, Corporate Controller | May 13, 2016 | Option Exercise | $82.71 | 207 | 17,121 | 14,923 | May 17, 2016, 03:01 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 06, 2016 | Option Exercise | $80.80 | 679 | 54,863 | 62,393 | May 12, 2016, 05:08 PM |
| Mueller Brian | VP, Corporate Controller | Apr 29, 2016 | Option Exercise | $51.26 | 327 | 16,763 | 15,574 | May 10, 2016, 07:18 PM |
| Mueller Brian | VP, Corporate Controller | May 06, 2016 | Option Exercise | $80.80 | 444 | 35,875 | 15,130 | May 10, 2016, 07:18 PM |
| BAFFI ROBERT | EVP, Technical Operations | Apr 29, 2016 | Option Exercise | $51.26 | 414 | 21,223 | 139,040 | May 10, 2016, 07:14 PM |
| BAFFI ROBERT | EVP, Technical Operations | May 06, 2016 | Option Exercise | $80.80 | 2,088 | 168,710 | 136,952 | May 10, 2016, 07:14 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | Apr 29, 2016 | Option Exercise | $51.26 | 415 | 21,275 | 121,081 | May 10, 2016, 07:08 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | May 06, 2016 | Option Exercise | $80.80 | 3,131 | 252,985 | 117,950 | May 10, 2016, 07:08 PM |
| Davis George Eric | EVP, General Counsel | Apr 29, 2016 | Option Exercise | $51.26 | 414 | 21,223 | 91,894 | May 10, 2016, 07:06 PM |
| Davis George Eric | EVP, General Counsel | May 06, 2016 | Option Exercise | $80.80 | 1,696 | 137,037 | 90,198 | May 10, 2016, 07:06 PM |
| Davis George Eric | EVP, General Counsel | May 10, 2016 | Sale | $86.32 | 4,658 | 402,079 | 75,540 | May 10, 2016, 07:06 PM |
| Davis George Eric | EVP, General Counsel | May 09, 2016 | Sale | $84.55 | 10,000 | 845,532 | 80,198 | May 10, 2016, 07:06 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 06, 2016 | Option Exercise | $80.80 | 5,479 | 442,703 | 390,156 | May 09, 2016, 08:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2016 | Option Exercise | $12.99 | 10,000 | 129,900 | 10,000 | May 09, 2016, 08:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2016 | Option Exercise | $12.99 | 20,000 | 259,800 | 20,000 | May 09, 2016, 08:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2016 | Option Exercise | $12.99 | 10,000 | 129,900 | 10,000 | May 09, 2016, 08:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2016 | Option Exercise | $12.99 | 10,000 | 129,900 | 10,000 | May 09, 2016, 08:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2016 | Option Exercise | $46.57 | 20,000 | 931,389 | 10,000 | May 09, 2016, 08:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2016 | Sale | $80.15 | 10,000 | 801,489 | 0 | May 09, 2016, 08:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2016 | Sale | $80.15 | 20,000 | 1,602,978 | 0 | May 09, 2016, 08:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2016 | Sale | $80.15 | 10,000 | 801,489 | 0 | May 09, 2016, 08:47 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 05, 2016 | Sale | $80.15 | 10,000 | 801,489 | 0 | May 09, 2016, 08:47 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | Apr 29, 2016 | Option Exercise | $51.26 | 415 | 21,275 | 63,487 | May 04, 2016, 04:16 PM |
| Ajer Jeffrey Robert | EVP, Chief Commercial Officer | May 03, 2016 | Sale | $86.03 | 415 | 35,701 | 63,072 | May 04, 2016, 04:16 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 29, 2016 | Option Exercise | $51.26 | 414 | 21,223 | 395,635 | May 04, 2016, 10:11 AM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 02, 2016 | Option Exercise | $12.99 | 36,500 | 474,135 | 432,135 | May 04, 2016, 10:11 AM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | May 02, 2016 | Sale | $85.01 | 36,500 | 3,102,931 | 395,635 | May 04, 2016, 10:11 AM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 05, 2016 | Option Exercise | $14.39 | 1,500 | 21,585 | 393,721 | Apr 07, 2016, 08:49 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Apr 06, 2016 | Option Exercise | $14.39 | 1,500 | 21,585 | 395,221 | Apr 07, 2016, 08:49 PM |
| Mueller Brian | VP, Corporate Controller | Mar 16, 2016 | Option Exercise | $80.34 | 376 | 30,208 | 15,247 | Mar 17, 2016, 05:20 PM |
| Davis George Eric | EVP, General Counsel | Mar 14, 2016 | Sale | $86.21 | 1,996 | 172,079 | 76,190 | Mar 16, 2016, 12:39 PM |
| BAFFI ROBERT | EVP, Technical Operations | Mar 03, 2016 | Option Exercise | $89.57 | 2,395 | 214,520 | 71,639 | Mar 07, 2016, 08:48 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 03, 2016 | Option Exercise | $89.57 | 8,989 | 805,145 | 331,511 | Mar 07, 2016, 08:47 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 03, 2016 | Option Exercise | $89.57 | 2,395 | 214,520 | 47,293 | Mar 07, 2016, 08:46 PM |
| Ajer Jeffrey Robert | SVP, Chief Commercial Officer | Mar 03, 2016 | Option Exercise | $89.57 | 2,395 | 214,520 | 48,137 | Mar 07, 2016, 08:45 PM |
| Ajer Jeffrey Robert | SVP, Chief Commercial Officer | Mar 04, 2016 | Sale | $88.42 | 1,255 | 110,970 | 46,882 | Mar 07, 2016, 08:45 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | Mar 03, 2016 | Option Exercise | $89.57 | 3,043 | 272,562 | 100,876 | Mar 07, 2016, 08:44 PM |
| Davis George Eric | EVP, General Counsel | Mar 03, 2016 | Option Exercise | $89.57 | 2,180 | 195,263 | 78,186 | Mar 07, 2016, 08:43 PM |
| BAFFI ROBERT | EVP, Technical Operations | Feb 29, 2016 | Option Exercise | $81.87 | 47,273 | 3,870,241 | 122,436 | Mar 02, 2016, 08:39 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Feb 29, 2016 | Option Exercise | $81.87 | 192,982 | 15,799,437 | 350,500 | Mar 02, 2016, 08:38 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Mar 01, 2016 | Sale | $84.28 | 10,000 | 842,769 | 345,479 | Mar 02, 2016, 08:38 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Feb 29, 2016 | Option Exercise | $81.87 | 46,766 | 3,828,733 | 54,311 | Mar 02, 2016, 08:37 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Mar 02, 2016 | Sale | $86.12 | 4,623 | 398,120 | 49,688 | Mar 02, 2016, 08:37 PM |
| Davis George Eric | EVP, General Counsel | Feb 29, 2016 | Option Exercise | $81.87 | 17,656 | 1,445,497 | 80,366 | Mar 02, 2016, 08:35 PM |
| Ajer Jeffrey Robert | SVP, Chief Commercial Officer | Feb 29, 2016 | Option Exercise | $81.87 | 17,656 | 1,445,497 | 50,532 | Mar 02, 2016, 08:33 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | Feb 29, 2016 | Option Exercise | $81.87 | 56,464 | 4,622,708 | 103,919 | Mar 02, 2016, 08:31 PM |
| GREY MICHAEL G | Director | Feb 22, 2016 | Option Exercise | $38.59 | 7,500 | 289,425 | 33,750 | Feb 23, 2016, 04:41 PM |
| GREY MICHAEL G | Director | Feb 22, 2016 | Sale | $80.00 | 7,500 | 600,000 | 26,250 | Feb 23, 2016, 04:41 PM |
| Davis George Eric | SVP, General Counsel | Dec 16, 2015 | Sale | $100.00 | 1,362 | 136,200 | 66,156 | Dec 17, 2015, 02:18 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Nov 30, 2015 | Sale | $94.74 | 1,000 | 94,744 | 25,758 | Dec 02, 2015, 06:58 PM |
| LAWLIS V BRYAN | Director | Nov 16, 2015 | Option Exercise | $17.33 | 7,500 | 129,975 | 19,350 | Nov 18, 2015, 05:10 PM |
| LAWLIS V BRYAN | Director | Nov 16, 2015 | Sale | $106.90 | 8,550 | 914,000 | 11,850 | Nov 18, 2015, 05:10 PM |
| GREY MICHAEL G | Director | Nov 16, 2015 | Option Exercise | $38.59 | 7,500 | 289,425 | 33,750 | Nov 18, 2015, 04:49 PM |
| GREY MICHAEL G | Director | Nov 16, 2015 | Sale | $104.27 | 7,500 | 782,055 | 26,250 | Nov 18, 2015, 04:49 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Nov 16, 2015 | Option Exercise | $39.06 | 20,000 | 781,200 | 48,229 | Nov 18, 2015, 04:03 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Nov 16, 2015 | Sale | $104.30 | 20,000 | 2,085,920 | 28,229 | Nov 18, 2015, 04:03 PM |
| Ajer Jeffrey Robert | SVP, Chief Commercial Of | Oct 30, 2015 | Option Exercise | $57.26 | 26 | 1,489 | 35,631 | Nov 06, 2015, 05:44 PM |
| Ajer Jeffrey Robert | SVP, Chief Commercial Of | Nov 02, 2015 | Sale | $117.56 | 26 | 3,057 | 35,605 | Nov 06, 2015, 05:44 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Oct 15, 2015 | Sale | $108.24 | 1,000 | 108,241 | 26,758 | Oct 19, 2015, 01:39 PM |
| HERON ELAINE J | Director | Sep 08, 2015 | Option Exercise | $21.51 | 15,000 | 322,650 | 35,625 | Sep 25, 2015, 12:42 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Sep 14, 2015 | Sale | $131.43 | 1,000 | 131,432 | 27,758 | Sep 16, 2015, 08:09 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Aug 12, 2015 | Sale | $134.72 | 1,500 | 202,083 | 28,758 | Aug 13, 2015, 10:40 AM |
| Ajer Jeffrey Robert | SVP, Chief Commercial Of | Jul 20, 2015 | Option Exercise | $63.10 | 3,000 | 189,300 | 38,605 | Jul 22, 2015, 03:21 PM |
| Ajer Jeffrey Robert | SVP, Chief Commercial Of | Jul 20, 2015 | Sale | $150.00 | 3,000 | 450,000 | 35,605 | Jul 22, 2015, 03:21 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jul 07, 2015 | Sale | $139.07 | 1,500 | 208,599 | 30,258 | Jul 09, 2015, 05:06 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Jun 04, 2015 | Option Exercise | $120.46 | 1,801 | 216,948 | 29,878 | Jun 08, 2015, 06:09 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | Jun 05, 2015 | Sale | $122.30 | 1,649 | 201,669 | 28,229 | Jun 08, 2015, 06:09 PM |
| Mueller Brian | VP, Corporate Controller | Jun 04, 2015 | Option Exercise | $120.46 | 522 | 62,880 | 11,926 | Jun 08, 2015, 06:08 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | Jun 04, 2015 | Option Exercise | $120.46 | 2,036 | 245,257 | 74,710 | Jun 08, 2015, 06:06 PM |
| FUCHS HENRY J | EVP, Chief Medical Officer | Jun 05, 2015 | Sale | $122.32 | 1,864 | 228,001 | 72,846 | Jun 08, 2015, 06:06 PM |
| Davis George Eric | SVP, General Counsel | Jun 04, 2015 | Option Exercise | $120.46 | 1,488 | 179,244 | 67,738 | Jun 08, 2015, 06:04 PM |
| BIENAIME JEAN JACQUES | Chief Executive Officer | Jun 04, 2015 | Option Exercise | $120.46 | 6,640 | 799,854 | 229,254 | Jun 08, 2015, 06:01 PM |
| BAFFI ROBERT | EVP, Technical Operations | Jun 04, 2015 | Option Exercise | $120.46 | 1,644 | 198,036 | 101,056 | Jun 08, 2015, 05:48 PM |
| Ajer Jeffrey Robert | SVP, Chief Commercial Of | Jun 04, 2015 | Option Exercise | $120.46 | 1,488 | 179,244 | 36,967 | Jun 08, 2015, 05:43 PM |
| Ajer Jeffrey Robert | SVP, Chief Commercial Of | Jun 04, 2015 | Sale | $122.35 | 1,362 | 166,646 | 35,605 | Jun 08, 2015, 05:43 PM |
| SPIEGELMAN DANIEL K | EVP, Chief Financial Officer | May 29, 2015 | Option Exercise | $125.57 | 4,305 | 540,579 | 37,202 | Jun 03, 2015, 08:27 PM |