. (AUXL)
$36.47 - (-)
Market Cap: -
As of 03/13/15 12:00 AM EDT. Market closed.
. (AUXL)
$36.47
- (-)
Market Cap: -
As of 03/13/15 12:00 AM EDT. Market closed.
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52 week range
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INSIDER TRANSACTIONS FOR
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| WILLS ALAN | EVP, Corporate Development | Jan 29, 2015 | Option Exercise | $36.53 | 30,743 | 1,123,042 | 0 | Jan 30, 2015, 09:40 AM |
| Tursi James Patrick | Chief Medical Officer | Jan 29, 2015 | Option Exercise | $36.53 | 29,236 | 1,067,991 | 0 | Jan 30, 2015, 09:39 AM |
| Saik Andrew | CFO | Jan 29, 2015 | Option Exercise | $36.53 | 10,000 | 365,300 | 0 | Jan 30, 2015, 09:38 AM |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | Jan 29, 2015 | Option Exercise | $36.53 | 38,721 | 1,414,478 | 0 | Jan 30, 2015, 09:37 AM |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | Jan 29, 2015 | Option Exercise | $36.53 | 13,767 | 502,908 | 0 | Jan 30, 2015, 09:36 AM |
| Glickman Mark A | EVP - Sales and Marketing | Jan 29, 2015 | Option Exercise | $36.53 | 27,911 | 1,019,589 | 0 | Jan 30, 2015, 09:35 AM |
| Armstrong Jennifer Lou | Senior Vice President, HR | Jan 29, 2015 | Option Exercise | $36.53 | 14,874 | 543,347 | 0 | Jan 30, 2015, 09:34 AM |
| ADAMS ADRIAN | CEO and President | Jan 29, 2015 | Option Exercise | $36.53 | 120,134 | 4,388,495 | 0 | Jan 30, 2015, 09:33 AM |
| MCKEE WILLIAM | Director | Jan 29, 2015 | Option Exercise | $36.53 | 10,000 | 365,300 | 0 | Jan 30, 2015, 09:32 AM |
| Lurker Nancy | Director | Jan 29, 2015 | Option Exercise | $36.53 | 10,000 | 365,300 | 0 | Jan 30, 2015, 09:31 AM |
| FRIEDMAN PAUL A | Director | Jan 29, 2015 | Option Exercise | $36.53 | 5,000 | 182,650 | 0 | Jan 30, 2015, 09:30 AM |
| FETZER OLIVER | Director | Jan 29, 2015 | Option Exercise | $36.53 | 10,000 | 365,300 | 0 | Jan 30, 2015, 09:29 AM |
| CLASSON ROLF A | Director | Jan 29, 2015 | Option Exercise | $36.53 | 10,000 | 365,300 | 0 | Jan 30, 2015, 09:29 AM |
| Brandt Peter C. | Director | Jan 29, 2015 | Option Exercise | $36.53 | 5,000 | 182,650 | 0 | Jan 30, 2015, 09:28 AM |
| CLASSON ROLF A | Director | Dec 31, 2014 | Option Exercise | $34.38 | 260 | 8,940 | 10,260 | Jan 05, 2015, 04:38 PM |
| MCKEE WILLIAM | Director | Dec 05, 2014 | Option Exercise | $30.61 | 15,000 | 459,150 | 28,000 | Dec 08, 2014, 04:19 PM |
| MCKEE WILLIAM | Director | Dec 05, 2014 | Sale | $34.00 | 18,000 | 612,000 | 10,000 | Dec 08, 2014, 04:19 PM |
| Lurker Nancy | Director | Dec 05, 2014 | Option Exercise | $19.67 | 25,000 | 491,650 | 42,430 | Dec 08, 2014, 04:18 PM |
| Lurker Nancy | Director | Dec 05, 2014 | Sale | $34.00 | 32,430 | 1,102,620 | 17,430 | Dec 08, 2014, 04:18 PM |
| ADAMS ADRIAN | CEO and President | Dec 05, 2014 | Option Exercise | $17.40 | 40,000 | 696,000 | 257,778 | Dec 08, 2014, 04:16 PM |
| ADAMS ADRIAN | CEO and President | Dec 05, 2014 | Sale | $33.97 | 40,000 | 1,358,704 | 217,778 | Dec 08, 2014, 04:16 PM |
| FRIEDMAN PAUL A | Director | Dec 04, 2014 | Option Exercise | $18.43 | 20,000 | 368,550 | 40,050 | Dec 08, 2014, 04:14 PM |
| FRIEDMAN PAUL A | Director | Dec 05, 2014 | Sale | $33.85 | 9,689 | 327,953 | 10,361 | Dec 08, 2014, 04:14 PM |
| FRIEDMAN PAUL A | Director | Dec 04, 2014 | Sale | $33.67 | 20,000 | 673,452 | 20,050 | Dec 08, 2014, 04:14 PM |
| FETZER OLIVER | Director | Dec 03, 2014 | Option Exercise | $23.95 | 50,000 | 1,197,350 | 69,197 | Dec 04, 2014, 04:05 PM |
| FETZER OLIVER | Director | Dec 02, 2014 | Option Exercise | $11.87 | 50,000 | 593,300 | 69,197 | Dec 04, 2014, 04:05 PM |
| FETZER OLIVER | Director | Dec 03, 2014 | Sale | $34.00 | 50,000 | 1,700,000 | 19,197 | Dec 04, 2014, 04:05 PM |
| FETZER OLIVER | Director | Dec 02, 2014 | Sale | $34.03 | 50,000 | 1,701,635 | 19,197 | Dec 04, 2014, 04:05 PM |
| CLASSON ROLF A | Director | Dec 02, 2014 | Option Exercise | $16.08 | 260,000 | 4,180,950 | 289,135 | Dec 04, 2014, 04:03 PM |
| CLASSON ROLF A | Director | Dec 02, 2014 | Sale | $33.81 | 279,135 | 9,436,534 | 29,135 | Dec 04, 2014, 04:03 PM |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | Nov 25, 2014 | Option Exercise | $17.78 | 23,750 | 422,225 | 41,569 | Nov 26, 2014, 10:55 AM |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | Nov 25, 2014 | Sale | $34.04 | 27,802 | 946,274 | 37,517 | Nov 26, 2014, 10:55 AM |
| Tursi James Patrick | Chief Medical Officer | Nov 25, 2014 | Option Exercise | $19.12 | 10,562 | 201,931 | 45,617 | Nov 26, 2014, 10:54 AM |
| Tursi James Patrick | Chief Medical Officer | Nov 25, 2014 | Sale | $34.12 | 13,713 | 467,929 | 35,055 | Nov 26, 2014, 10:54 AM |
| WILLS ALAN | EVP, Corporate Development | Nov 20, 2014 | Option Exercise | $23.32 | 142,875 | 3,331,297 | 187,335 | Nov 24, 2014, 04:59 PM |
| WILLS ALAN | EVP, Corporate Development | Nov 20, 2014 | Sale | $33.18 | 156,592 | 5,195,293 | 44,460 | Nov 24, 2014, 04:59 PM |
| Tursi James Patrick | Chief Medical Officer | Nov 21, 2014 | Option Exercise | $22.04 | 5,000 | 110,200 | 109,703 | Nov 24, 2014, 04:57 PM |
| Tursi James Patrick | Chief Medical Officer | Nov 20, 2014 | Option Exercise | $16.44 | 66,000 | 1,084,785 | 104,703 | Nov 24, 2014, 04:57 PM |
| Tursi James Patrick | Chief Medical Officer | Nov 20, 2014 | Sale | $33.15 | 66,000 | 2,188,124 | 103,503 | Nov 24, 2014, 04:57 PM |
| Tursi James Patrick | Chief Medical Officer | Nov 21, 2014 | Sale | $33.47 | 8,648 | 289,443 | 40,055 | Nov 24, 2014, 04:57 PM |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | Nov 21, 2014 | Option Exercise | $19.95 | 134,375 | 2,680,312 | 178,404 | Nov 24, 2014, 04:56 PM |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | Nov 21, 2014 | Sale | $33.43 | 139,683 | 4,669,929 | 173,096 | Nov 24, 2014, 04:56 PM |
| Glickman Mark A | EVP - Sales and Marketing | Nov 20, 2014 | Option Exercise | $20.55 | 40,750 | 837,250 | 75,863 | Nov 24, 2014, 04:54 PM |
| Glickman Mark A | EVP - Sales and Marketing | Nov 20, 2014 | Sale | $33.17 | 47,952 | 1,590,335 | 68,661 | Nov 24, 2014, 04:54 PM |
| Armstrong Jennifer Lou | Senior Vice President, HR | Nov 21, 2014 | Option Exercise | $24.62 | 69,412 | 1,708,942 | 90,677 | Nov 24, 2014, 04:52 PM |
| Armstrong Jennifer Lou | Senior Vice President, HR | Nov 21, 2014 | Sale | $33.50 | 75,803 | 2,539,106 | 84,286 | Nov 24, 2014, 04:52 PM |
| WILLS ALAN | EVP, Corporate Development | Oct 25, 2014 | Option Exercise | $31.34 | 836 | 26,200 | 44,460 | Oct 27, 2014, 04:32 PM |
| CLASSON ROLF A | Director | Sep 30, 2014 | Option Exercise | $29.85 | 313 | 9,343 | 29,135 | Oct 01, 2014, 04:36 PM |
| CLASSON ROLF A | Director | Jun 30, 2014 | Option Exercise | $20.06 | 597 | 11,976 | 28,822 | Jul 01, 2014, 04:41 PM |
| WILLS ALAN | EVP, Corporate Development | Jun 21, 2014 | Option Exercise | $21.18 | 168 | 3,558 | 45,296 | Jun 23, 2014, 04:34 PM |
| Fickenscher James E | Chief Financial Officer | Jun 21, 2014 | Option Exercise | $21.18 | 80 | 1,694 | 68,603 | Jun 23, 2014, 04:33 PM |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | May 07, 2014 | Option Exercise | $20.82 | 305 | 6,350 | 17,819 | May 08, 2014, 02:03 PM |
| CLASSON ROLF A | Director | Mar 31, 2014 | Option Exercise | $27.18 | 288 | 7,828 | 23,225 | Apr 01, 2014, 04:15 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Mar 14, 2014 | Option Exercise | $11.85 | 30,625 | 362,925 | 53,360 | Mar 17, 2014, 04:44 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Mar 14, 2014 | Option Exercise | $17.59 | 883 | 15,532 | 7,205 | Mar 17, 2014, 04:44 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Mar 14, 2014 | Sale | $29.50 | 30,625 | 903,438 | 22,735 | Mar 17, 2014, 04:44 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Mar 14, 2014 | Sale | $29.55 | 1,407 | 41,577 | 6,322 | Mar 17, 2014, 04:44 PM |
| CLASSON ROLF A | Director | Mar 05, 2014 | Option Exercise | $7.50 | 10,000 | 75,000 | 32,937 | Mar 06, 2014, 04:42 PM |
| CLASSON ROLF A | Director | Mar 05, 2014 | Sale | $31.85 | 10,000 | 318,477 | 22,937 | Mar 06, 2014, 04:42 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Mar 01, 2014 | Option Exercise | $30.75 | 175 | 5,381 | 6,322 | Mar 04, 2014, 05:33 PM |
| WILLS ALAN | EVP, Corporate Development | Feb 18, 2014 | Option Exercise | $28.30 | 704 | 19,923 | 30,964 | Feb 20, 2014, 05:40 PM |
| Tursi James Patrick | Chief Medical Officer | Feb 18, 2014 | Option Exercise | $28.30 | 704 | 19,923 | 23,705 | Feb 20, 2014, 05:39 PM |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | Feb 18, 2014 | Option Exercise | $28.30 | 623 | 17,631 | 27,729 | Feb 20, 2014, 05:37 PM |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | Feb 18, 2014 | Option Exercise | $28.30 | 535 | 15,140 | 12,624 | Feb 20, 2014, 05:36 PM |
| Glickman Mark A | EVP - Sales and Marketing | Feb 18, 2014 | Option Exercise | $28.30 | 704 | 19,923 | 22,613 | Feb 20, 2014, 05:35 PM |
| Fickenscher James E | Chief Financial Officer | Feb 18, 2014 | Option Exercise | $28.30 | 668 | 18,904 | 48,683 | Feb 20, 2014, 05:34 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Feb 18, 2014 | Option Exercise | $28.30 | 495 | 14,008 | 17,235 | Feb 20, 2014, 05:33 PM |
| Tursi James Patrick | Chief Medical Officer | Feb 17, 2014 | Option Exercise | $26.80 | 108 | 2,894 | 18,034 | Feb 19, 2014, 04:29 PM |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | Feb 07, 2014 | Option Exercise | $23.68 | 716 | 16,955 | 8,284 | Feb 11, 2014, 09:42 PM |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | Feb 07, 2014 | Option Exercise | $23.68 | 911 | 21,572 | 21,977 | Feb 11, 2014, 09:40 PM |
| Tursi James Patrick | Chief Medical Officer | Feb 07, 2014 | Option Exercise | $23.68 | 2,043 | 48,378 | 18,142 | Feb 11, 2014, 09:39 PM |
| WILLS ALAN | EVP, Corporate Development | Feb 07, 2014 | Option Exercise | $23.68 | 2,269 | 53,730 | 25,293 | Feb 11, 2014, 09:38 PM |
| Glickman Mark A | EVP - Sales and Marketing | Feb 07, 2014 | Option Exercise | $23.68 | 1,986 | 47,028 | 16,942 | Feb 11, 2014, 09:36 PM |
| Fickenscher James E | Chief Financial Officer | Feb 07, 2014 | Option Exercise | $23.68 | 2,156 | 51,054 | 42,976 | Feb 11, 2014, 09:35 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Feb 07, 2014 | Option Exercise | $23.68 | 1,069 | 25,314 | 12,855 | Feb 11, 2014, 09:33 PM |
| Glickman Mark A | EVP - Sales and Marketing | Feb 03, 2014 | Option Exercise | $24.70 | 388 | 9,584 | 18,928 | Feb 04, 2014, 04:38 PM |
| FRIEDMAN PAUL A | Director | Dec 31, 2013 | Option Exercise | $20.73 | 361 | 7,484 | 12,600 | Jan 02, 2014, 04:20 PM |
| CLASSON ROLF A | Director | Dec 31, 2013 | Option Exercise | $20.73 | 361 | 7,484 | 22,937 | Jan 02, 2014, 04:19 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Dec 13, 2013 | Option Exercise | $13.16 | 4,300 | 56,588 | 8,666 | Dec 16, 2013, 05:07 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Dec 13, 2013 | Sale | $20.50 | 4,602 | 94,341 | 4,366 | Dec 16, 2013, 05:07 PM |
| Fickenscher James E | Chief Financial Officer | Dec 11, 2013 | Option Exercise | $4.78 | 71,067 | 339,700 | 116,199 | Dec 12, 2013, 04:05 PM |
| Fickenscher James E | Chief Financial Officer | Dec 11, 2013 | Sale | $20.37 | 71,067 | 1,447,450 | 45,132 | Dec 12, 2013, 04:05 PM |
| WILLS ALAN | EVP, Corporate Development | Oct 25, 2013 | Option Exercise | $17.27 | 813 | 14,041 | 27,562 | Oct 29, 2013, 04:44 PM |
| FRIEDMAN PAUL A | Director | Sep 30, 2013 | Option Exercise | $18.20 | 411 | 7,480 | 12,239 | Oct 01, 2013, 04:22 PM |
| CLASSON ROLF A | Director | Sep 30, 2013 | Option Exercise | $18.20 | 411 | 7,480 | 22,576 | Oct 01, 2013, 04:21 PM |
| FETZER OLIVER | Director | Aug 15, 2013 | Sale | $18.75 | 1,900 | 35,633 | 15,928 | Aug 15, 2013, 04:42 PM |
| FRIEDMAN PAUL A | Director | Jun 28, 2013 | Option Exercise | $16.63 | 450 | 7,483 | 11,828 | Jul 02, 2013, 02:07 PM |
| CLASSON ROLF A | Director | Jun 28, 2013 | Option Exercise | $16.63 | 450 | 7,483 | 22,165 | Jul 02, 2013, 02:06 PM |
| WILLS ALAN | EVP, Corporate Development | Jun 21, 2013 | Option Exercise | $17.15 | 187 | 3,207 | 28,375 | Jun 25, 2013, 04:03 PM |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | Jun 21, 2013 | Option Exercise | $17.15 | 102 | 1,749 | 22,888 | Jun 25, 2013, 04:02 PM |
| Fickenscher James E | Chief Financial Officer | Jun 21, 2013 | Option Exercise | $17.15 | 80 | 1,372 | 45,132 | Jun 25, 2013, 04:00 PM |
| MCKEE WILLIAM | Director | May 20, 2013 | Sale | $15.10 | 2,000 | 30,209 | 8,000 | May 22, 2013, 04:50 PM |
| FRIEDMAN PAUL A | Director | Mar 28, 2013 | Option Exercise | $17.29 | 433 | 7,487 | 6,378 | Apr 02, 2013, 11:59 AM |
| CLASSON ROLF A | Director | Mar 28, 2013 | Option Exercise | $17.29 | 541 | 9,354 | 16,715 | Apr 02, 2013, 11:58 AM |
| WILLS ALAN | EVP, Corporate Development | Feb 07, 2013 | Option Exercise | $18.30 | 426 | 7,796 | 28,562 | Feb 11, 2013, 05:34 PM |
| Tursi James Patrick | Chief Medical Officer | Feb 07, 2013 | Option Exercise | $18.30 | 426 | 7,796 | 19,008 | Feb 11, 2013, 05:32 PM |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | Feb 07, 2013 | Option Exercise | $18.30 | 910 | 16,653 | 22,990 | Feb 11, 2013, 05:30 PM |
| Glickman Mark A | EVP - Sales and Marketing | Feb 07, 2013 | Option Exercise | $18.30 | 426 | 7,796 | 19,316 | Feb 11, 2013, 05:28 PM |
| Fickenscher James E | Chief Financial Officer | Feb 07, 2013 | Option Exercise | $18.30 | 482 | 8,821 | 45,212 | Feb 11, 2013, 05:26 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Feb 07, 2013 | Option Exercise | $18.30 | 333 | 6,094 | 13,353 | Feb 11, 2013, 05:25 PM |
| Glickman Mark A | EVP - Sales and Marketing | Feb 03, 2013 | Option Exercise | $18.85 | 398 | 7,502 | 2,602 | Feb 05, 2013, 04:18 PM |
| FRIEDMAN PAUL A | Director | Dec 31, 2012 | Option Exercise | $18.54 | 404 | 7,490 | 8,399 | Jan 03, 2013, 05:14 PM |
| FETZER OLIVER | Director | Dec 31, 2012 | Option Exercise | $18.54 | 214 | 3,967 | 11,097 | Jan 03, 2013, 05:12 PM |
| CLASSON ROLF A | Director | Dec 31, 2012 | Option Exercise | $18.54 | 404 | 7,490 | 16,174 | Jan 03, 2013, 05:10 PM |
| WILLS ALAN | EVP, Corporate Development | Oct 25, 2012 | Option Exercise | $21.01 | 826 | 17,354 | 9,848 | Oct 31, 2012, 05:13 PM |
| FRIEDMAN PAUL A | Director | Sep 28, 2012 | Option Exercise | $24.46 | 306 | 7,485 | 7,995 | Oct 02, 2012, 11:07 AM |
| FETZER OLIVER | Director | Sep 28, 2012 | Option Exercise | $24.46 | 163 | 3,987 | 10,883 | Oct 02, 2012, 11:06 AM |
| CLASSON ROLF A | Director | Sep 28, 2012 | Option Exercise | $24.46 | 306 | 7,485 | 15,770 | Oct 02, 2012, 11:05 AM |
| Lurker Nancy | Director | Jun 29, 2012 | Option Exercise | $26.89 | 417 | 11,213 | 7,430 | Jul 03, 2012, 10:07 AM |
| FRIEDMAN PAUL A | Director | Jun 29, 2012 | Option Exercise | $26.89 | 231 | 6,212 | 7,689 | Jul 03, 2012, 10:07 AM |
| FETZER OLIVER | Director | Jun 29, 2012 | Option Exercise | $26.89 | 120 | 3,227 | 10,720 | Jul 03, 2012, 10:06 AM |
| CLASSON ROLF A | Director | Jun 29, 2012 | Option Exercise | $26.89 | 220 | 5,916 | 15,464 | Jul 03, 2012, 10:05 AM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Jun 25, 2012 | Option Exercise | $5.50 | 12,682 | 69,751 | 17,152 | Jun 26, 2012, 05:15 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Jun 25, 2012 | Sale | $25.01 | 12,682 | 317,155 | 4,470 | Jun 26, 2012, 05:15 PM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Jun 06, 2012 | Option Exercise | $9.15 | 6,000 | 54,900 | 8,024 | Jun 08, 2012, 11:05 AM |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | Jun 06, 2012 | Sale | $22.55 | 6,000 | 135,302 | 7,724 | Jun 08, 2012, 11:05 AM |
| FUCHS RENATO | Director | Mar 30, 2012 | Option Exercise | $18.57 | 150 | 2,785 | 1,803 | Apr 03, 2012, 05:14 PM |
| FRIEDMAN PAUL A | Director | Mar 30, 2012 | Option Exercise | $18.57 | 336 | 6,240 | 2,454 | Apr 03, 2012, 05:13 PM |
| FETZER OLIVER | Director | Mar 30, 2012 | Option Exercise | $18.57 | 174 | 3,231 | 5,600 | Apr 03, 2012, 05:12 PM |
| CLASSON ROLF A | Director | Mar 30, 2012 | Option Exercise | $18.57 | 319 | 5,924 | 10,244 | Apr 03, 2012, 05:10 PM |
| Brandt Peter C. | Director | Feb 28, 2012 | Buy | $20.10 | 10,000 | 200,998 | 10,000 | Mar 01, 2012, 05:01 PM |
| Fickenscher James E | Chief Financial Officer | Feb 28, 2012 | Option Exercise | $20.07 | 1,053 | 21,134 | 25,786 | Mar 01, 2012, 05:00 PM |
| FRIEDMAN PAUL A | Director | Jan 05, 2012 | Option Exercise | $19.05 | 236 | 4,496 | 2,118 | Jan 06, 2012, 02:35 PM |
| FETZER OLIVER | Director | Jan 05, 2012 | Option Exercise | $19.05 | 141 | 2,686 | 5,426 | Jan 06, 2012, 02:34 PM |
| CLASSON ROLF A | Director | Jan 05, 2012 | Option Exercise | $19.05 | 118 | 2,248 | 9,925 | Jan 06, 2012, 02:33 PM |
| CLASSON ROLF A | Director | Dec 30, 2011 | Option Exercise | $19.93 | 297 | 5,919 | 9,807 | Jan 04, 2012, 05:28 PM |
| Lurker Nancy | Director | Dec 30, 2011 | Option Exercise | $19.93 | 563 | 11,221 | 1,408 | Jan 04, 2012, 04:59 PM |
| FUCHS RENATO | Director | Dec 30, 2011 | Option Exercise | $19.93 | 140 | 2,790 | 1,653 | Jan 04, 2012, 04:57 PM |
| FRIEDMAN PAUL A | Director | Dec 30, 2011 | Option Exercise | $19.93 | 312 | 6,218 | 1,882 | Jan 04, 2012, 04:54 PM |
| FETZER OLIVER | Director | Dec 30, 2011 | Option Exercise | $19.93 | 244 | 4,863 | 5,285 | Jan 04, 2012, 04:52 PM |
| Fickenscher James E | Chief Financial Officer | Nov 03, 2011 | Buy | $15.54 | 1,610 | 25,024 | 26,839 | Nov 07, 2011, 05:05 PM |
| WILLS ALAN | EVP, Corporate Development | Oct 25, 2011 | Option Exercise | $15.98 | 826 | 13,199 | 9,174 | Oct 27, 2011, 05:57 PM |
| ANIDO ARMANDO | CEO & President | Oct 07, 2011 | Option Exercise | $7.81 | 5,275 | 41,198 | 18,928 | Oct 11, 2011, 09:33 PM |
| ANIDO ARMANDO | CEO & President | Oct 07, 2011 | Sale | $14.23 | 5,275 | 75,046 | 13,653 | Oct 11, 2011, 09:33 PM |
| Lurker Nancy | Director | Sep 30, 2011 | Option Exercise | $14.99 | 750 | 11,242 | 845 | Oct 04, 2011, 05:14 PM |
| FUCHS RENATO | Director | Sep 30, 2011 | Option Exercise | $14.99 | 186 | 2,788 | 1,513 | Oct 04, 2011, 05:13 PM |
| FRIEDMAN PAUL A | Director | Sep 30, 2011 | Option Exercise | $14.99 | 416 | 6,236 | 1,570 | Oct 04, 2011, 05:12 PM |
| FETZER OLIVER | Director | Sep 30, 2011 | Option Exercise | $14.99 | 325 | 4,872 | 5,041 | Oct 04, 2011, 05:10 PM |
| CLASSON ROLF A | Director | Sep 30, 2011 | Option Exercise | $14.99 | 545 | 8,170 | 9,510 | Oct 04, 2011, 05:09 PM |
| FUCHS RENATO | Director | Mar 31, 2011 | Option Exercise | $21.47 | 130 | 2,791 | 1,185 | Oct 04, 2011, 04:44 PM |
| FRIEDMAN PAUL A | Director | Mar 31, 2011 | Option Exercise | $21.47 | 290 | 6,226 | 836 | Sep 30, 2011, 04:45 PM |
| CLASSON ROLF A | Director | Mar 31, 2011 | Option Exercise | $21.47 | 290 | 6,226 | 8,611 | Sep 30, 2011, 04:43 PM |
| 14159 capital (GP), LLC | 10% Owner | Aug 01, 2011 | Sale | $18.04 | 16,078 | 289,969 | 143,568 | Aug 03, 2011, 04:55 PM |
| 14159 capital (GP), LLC | 10% Owner | Aug 02, 2011 | Sale | $17.25 | 1,001 | 17,265 | 132,889 | Aug 03, 2011, 04:55 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Aug 02, 2011 | Sale | $17.25 | 6,361 | 109,715 | 844,839 | Aug 03, 2011, 04:54 PM |
| Baker Biotech Capital (GP), LLC | 10% Owner | Aug 01, 2011 | Sale | $18.04 | 102,209 | 1,843,355 | 912,719 | Aug 03, 2011, 04:54 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Aug 02, 2011 | Sale | $17.25 | 40,781 | 703,391 | 5,416,304 | Aug 03, 2011, 04:53 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Aug 01, 2011 | Sale | $18.04 | 655,272 | 11,817,934 | 5,851,489 | Aug 03, 2011, 04:53 PM |
| Baker / Tisch Capital (GP), LLC | 10% Owner | Aug 02, 2011 | Sale | $17.25 | 507 | 8,745 | 67,322 | Aug 03, 2011, 04:53 PM |
| Baker / Tisch Capital (GP), LLC | 10% Owner | Aug 01, 2011 | Sale | $18.04 | 8,145 | 146,896 | 72,731 | Aug 03, 2011, 04:53 PM |
| ANIDO ARMANDO | CEO & President | Jul 08, 2011 | Option Exercise | $7.81 | 5,275 | 41,198 | 18,928 | Jul 12, 2011, 07:49 PM |
| ANIDO ARMANDO | CEO & President | Jul 08, 2011 | Sale | $20.30 | 5,275 | 107,101 | 13,653 | Jul 12, 2011, 07:49 PM |
| Lurker Nancy | Director | Jun 30, 2011 | Option Exercise | $19.60 | 95 | 1,862 | 95 | Jul 05, 2011, 08:43 PM |
| FUCHS RENATO | Director | Jun 30, 2011 | Option Exercise | $19.60 | 142 | 2,783 | 1,327 | Jul 05, 2011, 08:42 PM |
| FRIEDMAN PAUL A | Director | Jun 30, 2011 | Option Exercise | $19.60 | 318 | 6,233 | 1,154 | Jul 05, 2011, 08:41 PM |
| FETZER OLIVER | Director | Jun 30, 2011 | Option Exercise | $19.60 | 248 | 4,861 | 4,716 | Jul 05, 2011, 08:40 PM |
| CLASSON ROLF A | Director | Jun 30, 2011 | Option Exercise | $19.60 | 354 | 6,938 | 8,965 | Jul 05, 2011, 08:39 PM |
| Chambon Philippe O. | Director | May 23, 2011 | Option Exercise | $21.77 | 21,726 | 472,953 | 7,554 | May 25, 2011, 03:33 PM |
| Chambon Philippe O. | Director | May 11, 2011 | Option Exercise | $23.00 | 718,858 | 16,533,734 | 29,280 | May 13, 2011, 04:31 PM |
| Chambon Philippe O. | Director | Mar 31, 2011 | Option Exercise | $21.47 | 697 | 14,965 | 748,138 | May 12, 2011, 08:28 PM |
| Stacey Jennifer Evans | Executive VP & General Counsel | Feb 28, 2011 | Option Exercise | $22.47 | 941 | 21,144 | 16,878 | Apr 04, 2011, 08:42 PM |
| Graham Roger D Jr | EVP, Sales & Marketing | Mar 19, 2011 | Option Exercise | $22.26 | 1,806 | 40,202 | 17,619 | Apr 04, 2011, 08:40 PM |
| Graham Roger D Jr | EVP, Sales & Marketing | Feb 28, 2011 | Option Exercise | $22.47 | 941 | 21,144 | 19,425 | Apr 04, 2011, 08:40 PM |
| Fickenscher James E | Chief Financial Officer | Feb 28, 2011 | Option Exercise | $22.47 | 941 | 21,144 | 25,247 | Apr 04, 2011, 08:38 PM |
| ANIDO ARMANDO | CEO & President | Feb 28, 2011 | Option Exercise | $22.47 | 2,419 | 54,355 | 13,653 | Apr 04, 2011, 08:36 PM |
| ANIDO ARMANDO | CEO & President | Mar 08, 2011 | Option Exercise | $7.81 | 10,555 | 82,435 | 18,933 | Apr 04, 2011, 08:36 PM |
| ANIDO ARMANDO | CEO & President | Mar 08, 2011 | Sale | $23.02 | 10,555 | 242,993 | 13,653 | Apr 04, 2011, 08:36 PM |
| FUCHS RENATO | Director | Mar 31, 2011 | Option Exercise | $21.47 | 261 | 5,604 | 1,316 | Apr 04, 2011, 08:33 PM |
| FRIEDMAN PAUL A | Director | Mar 31, 2011 | Option Exercise | $21.47 | 145 | 3,113 | 691 | Apr 04, 2011, 08:30 PM |
| FETZER OLIVER | Director | Mar 31, 2011 | Option Exercise | $21.47 | 226 | 4,852 | 4,468 | Apr 04, 2011, 08:28 PM |
| CLASSON ROLF A | Director | Mar 31, 2011 | Option Exercise | $21.47 | 1,164 | 24,991 | 9,485 | Apr 04, 2011, 08:26 PM |
| Chambon Philippe O. | Director | Mar 31, 2011 | Option Exercise | $21.47 | 174 | 3,736 | 747,615 | Apr 04, 2011, 08:25 PM |
| 14159 capital (GP), LLC | 10% Owner | Mar 30, 2011 | Buy | $21.98 | 3,911 | 85,963 | 149,968 | Mar 31, 2011, 06:01 PM |
| Baker Bros. Capital (GP), LLC | 10% Owner | Mar 30, 2011 | Buy | $21.98 | 309 | 6,792 | 6,992 | Mar 31, 2011, 05:59 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Mar 29, 2011 | Buy | $21.98 | 332,000 | 7,298,070 | 6,105,365 | Mar 31, 2011, 05:50 PM |
| 14159 capital (GP), LLC | 10% Owner | Mar 08, 2011 | Buy | $22.86 | 5,693 | 130,148 | 146,057 | Mar 10, 2011, 08:04 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Mar 08, 2011 | Buy | $22.86 | 206,216 | 4,714,316 | 4,991,092 | Mar 10, 2011, 08:03 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Mar 09, 2011 | Buy | $22.92 | 782,273 | 17,926,169 | 5,773,365 | Mar 10, 2011, 08:03 PM |
| CHAMBON PHILIPPE | Director | Mar 08, 2011 | Option Exercise | $22.76 | 718,858 | 16,361,208 | 747,441 | Mar 10, 2011, 05:41 PM |
| ANIDO ARMANDO | CEO & President | Mar 08, 2011 | Option Exercise | $7.81 | 10,555 | 82,435 | 21,352 | Mar 09, 2011, 07:15 PM |
| ANIDO ARMANDO | CEO & President | Mar 08, 2011 | Sale | $23.02 | 10,555 | 242,993 | 16,072 | Mar 09, 2011, 07:15 PM |
| ANIDO ARMANDO | CEO & President | Jan 10, 2011 | Option Exercise | $7.81 | 10,555 | 82,435 | 21,352 | Jan 12, 2011, 09:33 PM |
| ANIDO ARMANDO | CEO & President | Jan 10, 2011 | Sale | $23.22 | 10,555 | 245,050 | 16,072 | Jan 12, 2011, 09:33 PM |
| FUCHS RENATO | Director | Dec 31, 2010 | Option Exercise | $21.10 | 118 | 2,490 | 1,055 | Jan 04, 2011, 06:12 PM |
| FRIEDMAN PAUL A | Director | Dec 31, 2010 | Option Exercise | $21.10 | 295 | 6,225 | 546 | Jan 04, 2011, 06:10 PM |
| FETZER OLIVER | Director | Dec 31, 2010 | Option Exercise | $21.10 | 384 | 8,102 | 4,242 | Jan 04, 2011, 06:07 PM |
| CHAMBON PHILIPPE | Director | Dec 31, 2010 | Option Exercise | $21.10 | 709 | 14,960 | 6,857 | Jan 04, 2011, 06:04 PM |
| CLASSON ROLF A | Director | Dec 31, 2010 | Option Exercise | $21.10 | 296 | 6,246 | 8,321 | Jan 04, 2011, 06:02 PM |
| WILLS ALAN | EVP, Corporate Development | Oct 25, 2010 | Option Exercise | $25.90 | 10,000 | 259,000 | 10,000 | Oct 26, 2010, 06:26 PM |
| FUCHS RENATO | Director | Sep 30, 2010 | Option Exercise | $24.78 | 100 | 2,478 | 937 | Oct 04, 2010, 06:40 PM |
| FRIEDMAN PAUL A | Director | Sep 30, 2010 | Option Exercise | $24.78 | 251 | 6,220 | 251 | Oct 04, 2010, 06:37 PM |
| FETZER OLIVER | Director | Sep 30, 2010 | Option Exercise | $24.78 | 327 | 8,103 | 3,858 | Oct 04, 2010, 06:35 PM |
| CLASSON ROLF A | Director | Sep 30, 2010 | Option Exercise | $24.78 | 252 | 6,245 | 8,025 | Oct 04, 2010, 06:32 PM |
| CHAMBON PHILIPPE | Director | Sep 30, 2010 | Option Exercise | $24.78 | 604 | 14,967 | 6,148 | Oct 04, 2010, 06:29 PM |
| 14159 capital (GP), LLC | 10% Owner | Aug 27, 2010 | Buy | $25.82 | 964 | 24,892 | 140,364 | Aug 30, 2010, 04:47 PM |
| 14159 capital (GP), LLC | 10% Owner | Aug 26, 2010 | Buy | $25.36 | 2,088 | 52,951 | 139,400 | Aug 30, 2010, 04:47 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Aug 27, 2010 | Buy | $25.82 | 34,899 | 901,141 | 4,784,876 | Aug 30, 2010, 04:45 PM |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | Aug 26, 2010 | Buy | $25.36 | 75,648 | 1,918,414 | 4,749,977 | Aug 30, 2010, 04:45 PM |
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Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| WILLS ALAN | EVP, Corporate Development | 01/29/2015 | 1,123,042 |
| Tursi James Patrick | Chief Medical Officer | 01/29/2015 | 1,067,991 |
| Saik Andrew | CFO | 01/29/2015 | 365,300 |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | 01/29/2015 | 1,414,478 |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | 01/29/2015 | 502,908 |
| Glickman Mark A | EVP - Sales and Marketing | 01/29/2015 | 1,019,589 |
| Armstrong Jennifer Lou | Senior Vice President, HR | 01/29/2015 | 543,347 |
| ADAMS ADRIAN | CEO and President | 01/29/2015 | 4,388,495 |
| MCKEE WILLIAM | Director | 01/29/2015 | 365,300 |
| Lurker Nancy | Director | 01/29/2015 | 365,300 |
| FRIEDMAN PAUL A | Director | 01/29/2015 | 182,650 |
| FETZER OLIVER | Director | 01/29/2015 | 365,300 |
| CLASSON ROLF A | Director | 01/29/2015 | 365,300 |
| Brandt Peter C. | Director | 01/29/2015 | 182,650 |
| CLASSON ROLF A | Director | 12/31/2014 | 8,940 |
| MCKEE WILLIAM | Director | 12/05/2014 | 459,150 |
| MCKEE WILLIAM | Director | 12/05/2014 | 612,000 |
| Lurker Nancy | Director | 12/05/2014 | 491,650 |
| Lurker Nancy | Director | 12/05/2014 | 1,102,620 |
| ADAMS ADRIAN | CEO and President | 12/05/2014 | 696,000 |
| ADAMS ADRIAN | CEO and President | 12/05/2014 | 1,358,704 |
| FRIEDMAN PAUL A | Director | 12/04/2014 | 368,550 |
| FRIEDMAN PAUL A | Director | 12/05/2014 | 327,953 |
| FRIEDMAN PAUL A | Director | 12/04/2014 | 673,452 |
| FETZER OLIVER | Director | 12/03/2014 | 1,197,350 |
| FETZER OLIVER | Director | 12/02/2014 | 593,300 |
| FETZER OLIVER | Director | 12/03/2014 | 1,700,000 |
| FETZER OLIVER | Director | 12/02/2014 | 1,701,635 |
| CLASSON ROLF A | Director | 12/02/2014 | 4,180,950 |
| CLASSON ROLF A | Director | 12/02/2014 | 9,436,534 |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | 11/25/2014 | 422,225 |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | 11/25/2014 | 946,274 |
| Tursi James Patrick | Chief Medical Officer | 11/25/2014 | 201,931 |
| Tursi James Patrick | Chief Medical Officer | 11/25/2014 | 467,929 |
| WILLS ALAN | EVP, Corporate Development | 11/20/2014 | 3,331,297 |
| WILLS ALAN | EVP, Corporate Development | 11/20/2014 | 5,195,293 |
| Tursi James Patrick | Chief Medical Officer | 11/21/2014 | 110,200 |
| Tursi James Patrick | Chief Medical Officer | 11/20/2014 | 1,084,785 |
| Tursi James Patrick | Chief Medical Officer | 11/20/2014 | 2,188,124 |
| Tursi James Patrick | Chief Medical Officer | 11/21/2014 | 289,443 |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | 11/21/2014 | 2,680,312 |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | 11/21/2014 | 4,669,929 |
| Glickman Mark A | EVP - Sales and Marketing | 11/20/2014 | 837,250 |
| Glickman Mark A | EVP - Sales and Marketing | 11/20/2014 | 1,590,335 |
| Armstrong Jennifer Lou | Senior Vice President, HR | 11/21/2014 | 1,708,942 |
| Armstrong Jennifer Lou | Senior Vice President, HR | 11/21/2014 | 2,539,106 |
| WILLS ALAN | EVP, Corporate Development | 10/25/2014 | 26,200 |
| CLASSON ROLF A | Director | 09/30/2014 | 9,343 |
| CLASSON ROLF A | Director | 06/30/2014 | 11,976 |
| WILLS ALAN | EVP, Corporate Development | 06/21/2014 | 3,558 |
| Fickenscher James E | Chief Financial Officer | 06/21/2014 | 1,694 |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | 05/07/2014 | 6,350 |
| CLASSON ROLF A | Director | 03/31/2014 | 7,828 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 03/14/2014 | 362,925 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 03/14/2014 | 15,532 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 03/14/2014 | 903,438 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 03/14/2014 | 41,577 |
| CLASSON ROLF A | Director | 03/05/2014 | 75,000 |
| CLASSON ROLF A | Director | 03/05/2014 | 318,477 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 03/01/2014 | 5,381 |
| WILLS ALAN | EVP, Corporate Development | 02/18/2014 | 19,923 |
| Tursi James Patrick | Chief Medical Officer | 02/18/2014 | 19,923 |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | 02/18/2014 | 17,631 |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | 02/18/2014 | 15,140 |
| Glickman Mark A | EVP - Sales and Marketing | 02/18/2014 | 19,923 |
| Fickenscher James E | Chief Financial Officer | 02/18/2014 | 18,904 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 02/18/2014 | 14,008 |
| Tursi James Patrick | Chief Medical Officer | 02/17/2014 | 2,894 |
| JOBES ELIZABETH VARKI | Chief Compliance Officer | 02/07/2014 | 16,955 |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | 02/07/2014 | 21,572 |
| Tursi James Patrick | Chief Medical Officer | 02/07/2014 | 48,378 |
| WILLS ALAN | EVP, Corporate Development | 02/07/2014 | 53,730 |
| Glickman Mark A | EVP - Sales and Marketing | 02/07/2014 | 47,028 |
| Fickenscher James E | Chief Financial Officer | 02/07/2014 | 51,054 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 02/07/2014 | 25,314 |
| Glickman Mark A | EVP - Sales and Marketing | 02/03/2014 | 9,584 |
| FRIEDMAN PAUL A | Director | 12/31/2013 | 7,484 |
| CLASSON ROLF A | Director | 12/31/2013 | 7,484 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 12/13/2013 | 56,588 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 12/13/2013 | 94,341 |
| Fickenscher James E | Chief Financial Officer | 12/11/2013 | 339,700 |
| Fickenscher James E | Chief Financial Officer | 12/11/2013 | 1,447,450 |
| WILLS ALAN | EVP, Corporate Development | 10/25/2013 | 14,041 |
| FRIEDMAN PAUL A | Director | 09/30/2013 | 7,480 |
| CLASSON ROLF A | Director | 09/30/2013 | 7,480 |
| FETZER OLIVER | Director | 08/15/2013 | 35,633 |
| FRIEDMAN PAUL A | Director | 06/28/2013 | 7,483 |
| CLASSON ROLF A | Director | 06/28/2013 | 7,483 |
| WILLS ALAN | EVP, Corporate Development | 06/21/2013 | 3,207 |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | 06/21/2013 | 1,749 |
| Fickenscher James E | Chief Financial Officer | 06/21/2013 | 1,372 |
| MCKEE WILLIAM | Director | 05/20/2013 | 30,209 |
| FRIEDMAN PAUL A | Director | 03/28/2013 | 7,487 |
| CLASSON ROLF A | Director | 03/28/2013 | 9,354 |
| WILLS ALAN | EVP, Corporate Development | 02/07/2013 | 7,796 |
| Tursi James Patrick | Chief Medical Officer | 02/07/2013 | 7,796 |
| KOVEN ANDREW I | EVP, CAO, GC and Secretary | 02/07/2013 | 16,653 |
| Glickman Mark A | EVP - Sales and Marketing | 02/07/2013 | 7,796 |
| Fickenscher James E | Chief Financial Officer | 02/07/2013 | 8,821 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 02/07/2013 | 6,094 |
| Glickman Mark A | EVP - Sales and Marketing | 02/03/2013 | 7,502 |
| FRIEDMAN PAUL A | Director | 12/31/2012 | 7,490 |
| FETZER OLIVER | Director | 12/31/2012 | 3,967 |
| CLASSON ROLF A | Director | 12/31/2012 | 7,490 |
| WILLS ALAN | EVP, Corporate Development | 10/25/2012 | 17,354 |
| FRIEDMAN PAUL A | Director | 09/28/2012 | 7,485 |
| FETZER OLIVER | Director | 09/28/2012 | 3,987 |
| CLASSON ROLF A | Director | 09/28/2012 | 7,485 |
| Lurker Nancy | Director | 06/29/2012 | 11,213 |
| FRIEDMAN PAUL A | Director | 06/29/2012 | 6,212 |
| FETZER OLIVER | Director | 06/29/2012 | 3,227 |
| CLASSON ROLF A | Director | 06/29/2012 | 5,916 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 06/25/2012 | 69,751 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 06/25/2012 | 317,155 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 06/06/2012 | 54,900 |
| DEL TITO BENJAMIN J JR | EVP, Reg Affairs & Project Mgt | 06/06/2012 | 135,302 |
| FUCHS RENATO | Director | 03/30/2012 | 2,785 |
| FRIEDMAN PAUL A | Director | 03/30/2012 | 6,240 |
| FETZER OLIVER | Director | 03/30/2012 | 3,231 |
| CLASSON ROLF A | Director | 03/30/2012 | 5,924 |
| Brandt Peter C. | Director | 02/28/2012 | 200,998 |
| Fickenscher James E | Chief Financial Officer | 02/28/2012 | 21,134 |
| FRIEDMAN PAUL A | Director | 01/05/2012 | 4,496 |
| FETZER OLIVER | Director | 01/05/2012 | 2,686 |
| CLASSON ROLF A | Director | 01/05/2012 | 2,248 |
| CLASSON ROLF A | Director | 12/30/2011 | 5,919 |
| Lurker Nancy | Director | 12/30/2011 | 11,221 |
| FUCHS RENATO | Director | 12/30/2011 | 2,790 |
| FRIEDMAN PAUL A | Director | 12/30/2011 | 6,218 |
| FETZER OLIVER | Director | 12/30/2011 | 4,863 |
| Fickenscher James E | Chief Financial Officer | 11/03/2011 | 25,024 |
| WILLS ALAN | EVP, Corporate Development | 10/25/2011 | 13,199 |
| ANIDO ARMANDO | CEO & President | 10/07/2011 | 41,198 |
| ANIDO ARMANDO | CEO & President | 10/07/2011 | 75,046 |
| Lurker Nancy | Director | 09/30/2011 | 11,242 |
| FUCHS RENATO | Director | 09/30/2011 | 2,788 |
| FRIEDMAN PAUL A | Director | 09/30/2011 | 6,236 |
| FETZER OLIVER | Director | 09/30/2011 | 4,872 |
| CLASSON ROLF A | Director | 09/30/2011 | 8,170 |
| FUCHS RENATO | Director | 03/31/2011 | 2,791 |
| FRIEDMAN PAUL A | Director | 03/31/2011 | 6,226 |
| CLASSON ROLF A | Director | 03/31/2011 | 6,226 |
| 14159 capital (GP), LLC | 10% Owner | 08/01/2011 | 289,969 |
| 14159 capital (GP), LLC | 10% Owner | 08/02/2011 | 17,265 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 08/02/2011 | 109,715 |
| Baker Biotech Capital (GP), LLC | 10% Owner | 08/01/2011 | 1,843,355 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 08/02/2011 | 703,391 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 08/01/2011 | 11,817,934 |
| Baker / Tisch Capital (GP), LLC | 10% Owner | 08/02/2011 | 8,745 |
| Baker / Tisch Capital (GP), LLC | 10% Owner | 08/01/2011 | 146,896 |
| ANIDO ARMANDO | CEO & President | 07/08/2011 | 41,198 |
| ANIDO ARMANDO | CEO & President | 07/08/2011 | 107,101 |
| Lurker Nancy | Director | 06/30/2011 | 1,862 |
| FUCHS RENATO | Director | 06/30/2011 | 2,783 |
| FRIEDMAN PAUL A | Director | 06/30/2011 | 6,233 |
| FETZER OLIVER | Director | 06/30/2011 | 4,861 |
| CLASSON ROLF A | Director | 06/30/2011 | 6,938 |
| Chambon Philippe O. | Director | 05/23/2011 | 472,953 |
| Chambon Philippe O. | Director | 05/11/2011 | 16,533,734 |
| Chambon Philippe O. | Director | 03/31/2011 | 14,965 |
| Stacey Jennifer Evans | Executive VP & General Counsel | 02/28/2011 | 21,144 |
| Graham Roger D Jr | EVP, Sales & Marketing | 03/19/2011 | 40,202 |
| Graham Roger D Jr | EVP, Sales & Marketing | 02/28/2011 | 21,144 |
| Fickenscher James E | Chief Financial Officer | 02/28/2011 | 21,144 |
| ANIDO ARMANDO | CEO & President | 02/28/2011 | 54,355 |
| ANIDO ARMANDO | CEO & President | 03/08/2011 | 82,435 |
| ANIDO ARMANDO | CEO & President | 03/08/2011 | 242,993 |
| FUCHS RENATO | Director | 03/31/2011 | 5,604 |
| FRIEDMAN PAUL A | Director | 03/31/2011 | 3,113 |
| FETZER OLIVER | Director | 03/31/2011 | 4,852 |
| CLASSON ROLF A | Director | 03/31/2011 | 24,991 |
| Chambon Philippe O. | Director | 03/31/2011 | 3,736 |
| 14159 capital (GP), LLC | 10% Owner | 03/30/2011 | 85,963 |
| Baker Bros. Capital (GP), LLC | 10% Owner | 03/30/2011 | 6,792 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 03/29/2011 | 7,298,070 |
| 14159 capital (GP), LLC | 10% Owner | 03/08/2011 | 130,148 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 03/08/2011 | 4,714,316 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 03/09/2011 | 17,926,169 |
| CHAMBON PHILIPPE | Director | 03/08/2011 | 16,361,208 |
| ANIDO ARMANDO | CEO & President | 03/08/2011 | 82,435 |
| ANIDO ARMANDO | CEO & President | 03/08/2011 | 242,993 |
| ANIDO ARMANDO | CEO & President | 01/10/2011 | 82,435 |
| ANIDO ARMANDO | CEO & President | 01/10/2011 | 245,050 |
| FUCHS RENATO | Director | 12/31/2010 | 2,490 |
| FRIEDMAN PAUL A | Director | 12/31/2010 | 6,225 |
| FETZER OLIVER | Director | 12/31/2010 | 8,102 |
| CHAMBON PHILIPPE | Director | 12/31/2010 | 14,960 |
| CLASSON ROLF A | Director | 12/31/2010 | 6,246 |
| WILLS ALAN | EVP, Corporate Development | 10/25/2010 | 259,000 |
| FUCHS RENATO | Director | 09/30/2010 | 2,478 |
| FRIEDMAN PAUL A | Director | 09/30/2010 | 6,220 |
| FETZER OLIVER | Director | 09/30/2010 | 8,103 |
| CLASSON ROLF A | Director | 09/30/2010 | 6,245 |
| CHAMBON PHILIPPE | Director | 09/30/2010 | 14,967 |
| 14159 capital (GP), LLC | 10% Owner | 08/27/2010 | 24,892 |
| 14159 capital (GP), LLC | 10% Owner | 08/26/2010 | 52,951 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 08/27/2010 | 901,141 |
| Baker Brothers Life Sciences Capital (GP), LLC | 10% Owner | 08/26/2010 | 1,918,414 |
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