Apellis Pharmaceuticals Inc. (APLS) NASDAQ
$68.66 0.71 (1.04%)
Market Cap: $7.47B
As of 08/15/22 12:09 PM EDT. Market open.
Apellis Pharmaceuticals Inc. (APLS) NASDAQ
$68.66 0.71 (1.04%)
Market Cap: $7.47B
As of 08/15/22 12:09 PM EDT. Market open.
Apellis Pharmaceuticals, Inc. is a global biopharmaceutical company that is committed to leveraging courageous science, creativity, and compassion to deliver life-changing therapies. Leaders in targeted C3 therapies, the company aims to develop transformative therapies for a broad range of debilitating diseases that are driven by excessive activation of the complement cascade, including those ... read more
Apellis Pharmaceuticals, Inc. is a global biopharmaceutical company that is committed to leveraging courageous science, creativity, and compassion to deliver life-changing therapies. Leaders in targeted C3 therapies, the company aims to develop transformative therapies for a broad range of debilitating diseases that are driven by excessive activation of the complement cascade, including those within hematology, ophthalmology, nephrology, and neurology. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
Cedric Francois
Full Time Employees
374
CEO Compensation (Base)
$550,000
CEO Compensation (Total)
$4.07M
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
Cedric Francois
Full Time Employees
374
CEO Compensation (Base)
$550,000
CEO Compensation (Total)
$4.07M
URL
Address
100 Fifth Avenue, Massachusetts, Waltham, 02451.
PRICE CHART
From:
To:
NEWS
KEY STATS
Open
$67.70
Previous Close
$67.95
Days Range
$66.10 - $68.87
52 week range
$27.50 - $68.87
Volume
329,811
Avg. Volume (30 days)
1,448,010
Market Cap
$7.47B
Dividend Yield
0.00%
P/E
-
Shares Outstanding
109,865,305
Open
$67.70
Previous Close
$67.95
Days Range
$66.10 - $68.87
52 week range
$27.50 - $68.87
Volume
329,811
Avg. Volume (30 days)
1,448,010
Market Cap
$7.47B
Dividend Yield
0.00%
P/E
-
Shares Outstanding
109,865,305
Open in:
Open in:
INSIDER TRANSACTIONS FOR APELLIS PHARMACEUTICALS INC
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Townsend Adam J. | Chief Commercial Officer | Aug 11, 2022 | Option Exercise | $15.09 | 12,500 | 188,625 | 55,407 | Aug 12, 2022, 05:01 PM |
| Townsend Adam J. | Chief Commercial Officer | Aug 11, 2022 | Sale | $67.00 | 12,500 | 837,500 | 42,907 | Aug 12, 2022, 05:01 PM |
| DeLong Mark Jeffrey | Senior Vice President | Aug 11, 2022 | Option Exercise | $15.52 | 5,000 | 77,600 | 34,250 | Aug 12, 2022, 04:58 PM |
| DeLong Mark Jeffrey | Senior Vice President | Aug 11, 2022 | Sale | $67.00 | 5,000 | 335,000 | 29,250 | Aug 12, 2022, 04:58 PM |
| Dunlop A. Sinclair | Director | Aug 11, 2022 | Sale | $65.63 | 30,000 | 1,968,900 | 255,679 | Aug 12, 2022, 04:57 PM |
| Townsend Adam J. | Chief Commercial Officer | Aug 08, 2022 | Option Exercise | $15.09 | 12,500 | 188,625 | 55,407 | Aug 09, 2022, 05:22 PM |
| Townsend Adam J. | Chief Commercial Officer | Aug 08, 2022 | Sale | $65.00 | 12,500 | 812,500 | 42,907 | Aug 09, 2022, 05:22 PM |
| Deschatelets Pascal | Chief Scientific Officer | Aug 08, 2022 | Option Exercise | $2.67 | 18,500 | 49,395 | 956,280 | Aug 09, 2022, 05:18 PM |
| Deschatelets Pascal | Chief Scientific Officer | Aug 08, 2022 | Sale | $62.50 | 12,000 | 750,000 | 944,280 | Aug 09, 2022, 05:18 PM |
| DeLong Mark Jeffrey | Senior Vice President | Aug 08, 2022 | Option Exercise | $15.52 | 5,000 | 77,600 | 34,250 | Aug 09, 2022, 05:16 PM |
| DeLong Mark Jeffrey | Senior Vice President | Aug 08, 2022 | Sale | $64.50 | 5,000 | 322,500 | 29,250 | Aug 09, 2022, 05:16 PM |
| DeLong Mark Jeffrey | Senior Vice President | Aug 04, 2022 | Option Exercise | $15.52 | 10,000 | 155,200 | 39,250 | Aug 08, 2022, 04:02 PM |
| DeLong Mark Jeffrey | Senior Vice President | Aug 04, 2022 | Sale | $60.75 | 10,000 | 607,500 | 34,250 | Aug 08, 2022, 04:02 PM |
| Townsend Adam J. | Chief Commercial Officer | Aug 03, 2022 | Option Exercise | $15.09 | 5,000 | 75,450 | 42,907 | Aug 04, 2022, 06:40 PM |
| Townsend Adam J. | Chief Commercial Officer | Aug 03, 2022 | Sale | $56.43 | 5,000 | 282,150 | 37,907 | Aug 04, 2022, 06:40 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Aug 01, 2022 | Sale | $55.99 | 2,500 | 139,975 | 107,384 | Aug 02, 2022, 04:18 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jul 27, 2022 | Option Exercise | $15.52 | 5,000 | 77,600 | 34,250 | Jul 28, 2022, 04:03 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jul 27, 2022 | Sale | $57.00 | 5,000 | 285,000 | 29,250 | Jul 28, 2022, 04:03 PM |
| Dunlop A. Sinclair | Director | Jul 21, 2022 | Option Exercise | $14.00 | 9,606 | 134,484 | 100,730 | Jul 22, 2022, 04:01 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jul 19, 2022 | Option Exercise | $15.52 | 5,000 | 77,600 | 34,250 | Jul 21, 2022, 04:31 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jul 19, 2022 | Sale | $56.42 | 5,000 | 282,100 | 29,250 | Jul 21, 2022, 04:31 PM |
| Machiels Alec | Director | Jul 15, 2022 | Option Exercise | $2.67 | 1,250 | 3,338 | 265,024 | Jul 18, 2022, 05:29 PM |
| Machiels Alec | Director | Jul 15, 2022 | Sale | $46.33 | 1,250 | 57,913 | 263,774 | Jul 18, 2022, 05:29 PM |
| Townsend Adam J. | Chief Commercial Officer | Jul 11, 2022 | Option Exercise | $15.09 | 5,000 | 75,450 | 47,907 | Jul 12, 2022, 05:55 PM |
| Townsend Adam J. | Chief Commercial Officer | Jul 11, 2022 | Sale | $48.42 | 5,000 | 242,100 | 42,907 | Jul 12, 2022, 05:55 PM |
| Deschatelets Pascal | Chief Scientific Officer | Jul 08, 2022 | Option Exercise | $2.67 | 18,500 | 49,395 | 949,780 | Jul 12, 2022, 04:04 PM |
| Deschatelets Pascal | Chief Scientific Officer | Jul 08, 2022 | Sale | $47.95 | 12,000 | 575,400 | 937,780 | Jul 12, 2022, 04:04 PM |
| Dunlop A. Sinclair | Director | Jun 27, 2022 | Sale | $46.79 | 1,341 | 62,743 | 1,341 | Jun 29, 2022, 04:18 PM |
| Dunlop A. Sinclair | Director | Jun 23, 2022 | Sale | $45.00 | 15,000 | 675,000 | 285,679 | Jun 24, 2022, 05:15 PM |
| Watson David O. | General Counsel | Jun 22, 2022 | Sale | $44.51 | 10,000 | 445,140 | 115,569 | Jun 23, 2022, 04:22 PM |
| Deschatelets Pascal | Chief Scientific Officer | Jun 17, 2022 | Option Exercise | $2.67 | 33,005 | 88,123 | 931,280 | Jun 22, 2022, 04:32 PM |
| Brown Victoria L. | Program Team Lead | Jun 17, 2022 | Sale | $45.00 | 2,698 | 121,410 | 24,974 | Jun 22, 2022, 04:26 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jun 16, 2022 | Option Exercise | $13.85 | 10,000 | 138,500 | 39,250 | Jun 21, 2022, 04:11 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jun 16, 2022 | Sale | $41.78 | 10,000 | 417,850 | 29,250 | Jun 21, 2022, 04:11 PM |
| Machiels Alec | Director | Jun 15, 2022 | Option Exercise | $2.67 | 1,250 | 3,338 | 265,024 | Jun 17, 2022, 05:02 PM |
| Machiels Alec | Director | Jun 15, 2022 | Sale | $39.29 | 1,250 | 49,113 | 263,774 | Jun 17, 2022, 05:02 PM |
| Deschatelets Pascal | Chief Scientific Officer | Jun 08, 2022 | Option Exercise | $2.67 | 18,500 | 49,395 | 903,775 | Jun 09, 2022, 05:23 PM |
| Deschatelets Pascal | Chief Scientific Officer | Jun 08, 2022 | Sale | $44.09 | 12,000 | 529,080 | 891,775 | Jun 09, 2022, 05:23 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jun 01, 2022 | Sale | $41.78 | 2,500 | 104,450 | 109,561 | Jun 02, 2022, 06:24 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | May 27, 2022 | Sale | $43.00 | 10,000 | 430,000 | 40,358 | May 31, 2022, 04:30 PM |
| Machiels Alec | Director | May 16, 2022 | Option Exercise | $2.67 | 1,250 | 3,338 | 265,024 | May 17, 2022, 05:26 PM |
| Machiels Alec | Director | May 16, 2022 | Sale | $39.18 | 1,250 | 48,975 | 263,774 | May 17, 2022, 05:26 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | May 02, 2022 | Sale | $43.56 | 2,500 | 108,900 | 112,061 | May 03, 2022, 07:56 PM |
| Deschatelets Pascal | Chief Scientific Officer | Apr 29, 2022 | Option Exercise | $2.67 | 4,000 | 10,680 | 895,775 | May 02, 2022, 08:05 PM |
| Deschatelets Pascal | Chief Scientific Officer | Apr 29, 2022 | Sale | $44.43 | 4,000 | 177,720 | 891,775 | May 02, 2022, 08:05 PM |
| Watson David O. | General Counsel | Apr 25, 2022 | Sale | $50.00 | 5,000 | 250,000 | 125,569 | Apr 27, 2022, 04:39 PM |
| Dunlop A. Sinclair | Director | Apr 22, 2022 | Option Exercise | $14.00 | 20,000 | 280,000 | 91,124 | Apr 25, 2022, 09:35 PM |
| DeLong Mark Jeffrey | Senior Vice President | Apr 20, 2022 | Option Exercise | $15.52 | 7,000 | 108,640 | 35,481 | Apr 22, 2022, 05:35 PM |
| DeLong Mark Jeffrey | Senior Vice President | Apr 20, 2022 | Sale | $52.53 | 7,000 | 367,710 | 28,481 | Apr 22, 2022, 05:35 PM |
| Machiels Alec | Director | Apr 14, 2022 | Option Exercise | $2.67 | 1,250 | 3,338 | 265,024 | Apr 18, 2022, 07:42 PM |
| Machiels Alec | Director | Apr 14, 2022 | Sale | $50.90 | 1,250 | 63,625 | 263,774 | Apr 18, 2022, 07:42 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Apr 05, 2022 | Option Exercise | $13.85 | 609 | 8,435 | 52,842 | Apr 06, 2022, 04:10 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Apr 05, 2022 | Sale | $60.09 | 609 | 36,593 | 52,233 | Apr 06, 2022, 04:10 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Apr 04, 2022 | Option Exercise | $13.85 | 3,504 | 48,530 | 55,737 | Apr 05, 2022, 04:08 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Apr 04, 2022 | Sale | $56.96 | 3,504 | 199,589 | 54,919 | Apr 05, 2022, 04:08 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Apr 01, 2022 | Option Exercise | $13.85 | 11,496 | 159,220 | 63,729 | Apr 04, 2022, 05:03 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Apr 01, 2022 | Sale | $55.05 | 11,496 | 632,855 | 52,233 | Apr 04, 2022, 05:03 PM |
| Brown Victoria L. | Program Team Lead | Mar 25, 2022 | Option Exercise | $49.28 | 82 | 4,041 | 28,325 | Mar 29, 2022, 04:12 PM |
| Machiels Alec | Director | Mar 15, 2022 | Option Exercise | $2.67 | 1,250 | 3,338 | 260,794 | Mar 17, 2022, 08:59 PM |
| Machiels Alec | Director | Mar 15, 2022 | Sale | $39.57 | 1,250 | 49,462 | 259,544 | Mar 17, 2022, 08:59 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Mar 15, 2022 | Option Exercise | $4.31 | 7,000 | 30,170 | 116,811 | Mar 17, 2022, 06:19 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Mar 15, 2022 | Sale | $39.57 | 375 | 14,839 | 116,436 | Mar 17, 2022, 06:19 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Mar 01, 2022 | Sale | $43.53 | 375 | 16,324 | 109,811 | Mar 02, 2022, 06:15 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Feb 23, 2022 | Option Exercise | $4.31 | 4,100 | 17,671 | 110,186 | Feb 24, 2022, 04:33 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Feb 15, 2022 | Sale | $45.43 | 375 | 17,036 | 106,086 | Feb 16, 2022, 04:29 PM |
| Machiels Alec | Director | Feb 15, 2022 | Option Exercise | $2.67 | 1,250 | 3,338 | 675,024 | Feb 16, 2022, 04:29 PM |
| Machiels Alec | Director | Feb 15, 2022 | Sale | $45.43 | 1,250 | 56,788 | 673,774 | Feb 16, 2022, 04:29 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Feb 14, 2022 | Option Exercise | $4.31 | 3,600 | 15,516 | 106,461 | Feb 15, 2022, 04:59 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Feb 14, 2022 | Option Exercise | $26.73 | 720 | 19,246 | 52,233 | Feb 15, 2022, 04:58 PM |
| Watson David O. | General Counsel | Feb 10, 2022 | Option Exercise | $47.12 | 491 | 23,136 | 132,444 | Feb 14, 2022, 06:36 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Feb 10, 2022 | Option Exercise | $47.12 | 705 | 33,220 | 102,861 | Feb 14, 2022, 04:29 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Feb 08, 2022 | Option Exercise | $13.85 | 10,000 | 138,500 | 63,857 | Feb 10, 2022, 08:32 AM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Feb 08, 2022 | Sale | $45.00 | 10,000 | 450,000 | 53,857 | Feb 10, 2022, 08:32 AM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Feb 01, 2022 | Sale | $40.58 | 375 | 15,218 | 103,566 | Feb 02, 2022, 04:50 PM |
| Brown Victoria L. | Program Team Lead | Jan 28, 2022 | Option Exercise | $38.59 | 434 | 16,748 | 28,582 | Feb 01, 2022, 06:11 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jan 28, 2022 | Option Exercise | $38.59 | 434 | 16,748 | 20,530 | Feb 01, 2022, 06:10 PM |
| Eisele Jeffrey | Exec VP, Program Team Lead | Jan 28, 2022 | Option Exercise | $38.59 | 434 | 16,748 | 32,989 | Feb 01, 2022, 06:09 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jan 28, 2022 | Option Exercise | $38.59 | 650 | 25,084 | 103,941 | Feb 01, 2022, 06:07 PM |
| Nicholson Nur | Chief Technical Officer | Jan 28, 2022 | Option Exercise | $38.59 | 650 | 25,084 | 35,555 | Feb 01, 2022, 06:06 PM |
| Sullivan Timothy Eugene | Chief Financial Officer | Jan 28, 2022 | Option Exercise | $38.59 | 650 | 25,084 | 104,278 | Feb 01, 2022, 06:05 PM |
| Watson David O. | General Counsel | Jan 28, 2022 | Option Exercise | $38.59 | 650 | 25,084 | 132,935 | Feb 01, 2022, 06:03 PM |
| Townsend Adam J. | Chief Commercial Officer | Jan 28, 2022 | Option Exercise | $38.59 | 800 | 30,872 | 44,908 | Feb 01, 2022, 06:01 PM |
| Deschatelets Pascal | Chief Scientific Officer | Jan 28, 2022 | Option Exercise | $38.59 | 931 | 35,927 | 894,707 | Feb 01, 2022, 06:00 PM |
| Francois Cedric | Chief Executive Officer | Jan 28, 2022 | Option Exercise | $38.59 | 2,024 | 78,106 | 1,338,463 | Feb 01, 2022, 06:00 PM |
| Lewis Karen | Chief People Officer | Jan 28, 2022 | Option Exercise | $38.59 | 434 | 16,748 | 23,474 | Feb 01, 2022, 05:59 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Jan 28, 2022 | Option Exercise | $38.59 | 642 | 24,775 | 55,090 | Feb 01, 2022, 05:58 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Jan 31, 2022 | Sale | $38.47 | 1,233 | 47,434 | 53,857 | Feb 01, 2022, 05:58 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Jan 21, 2022 | Option Exercise | $26.73 | 3,021 | 80,751 | 29,681 | Jan 24, 2022, 05:26 PM |
| Machiels Alec | Director | Jan 14, 2022 | Option Exercise | $2.67 | 1,250 | 3,338 | 675,024 | Jan 19, 2022, 08:15 PM |
| Machiels Alec | Director | Jan 14, 2022 | Sale | $40.56 | 1,250 | 50,700 | 673,774 | Jan 19, 2022, 08:15 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jan 14, 2022 | Option Exercise | $4.31 | 3,400 | 14,654 | 78,915 | Jan 19, 2022, 08:03 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jan 14, 2022 | Sale | $40.56 | 375 | 15,210 | 78,540 | Jan 19, 2022, 08:03 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jan 12, 2022 | Option Exercise | $3.92 | 5,161 | 20,230 | 75,515 | Jan 14, 2022, 04:57 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jan 03, 2022 | Sale | $47.31 | 375 | 17,741 | 70,354 | Jan 04, 2022, 04:07 PM |
| Watson David O. | General Counsel | Dec 27, 2021 | Sale | $48.50 | 1,200 | 58,200 | 107,534 | Dec 28, 2021, 05:38 PM |
| Watson David O. | General Counsel | Dec 22, 2021 | Option Exercise | $14.40 | 20,112 | 289,674 | 114,131 | Dec 23, 2021, 04:58 PM |
| Watson David O. | General Counsel | Dec 22, 2021 | Sale | $47.81 | 10,571 | 505,373 | 109,034 | Dec 23, 2021, 04:58 PM |
| Eisele Jeffrey | Exec VP, Program Team Lead | Dec 22, 2021 | Option Exercise | $47.82 | 89 | 4,256 | 7,372 | Dec 23, 2021, 04:49 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Dec 15, 2021 | Sale | $42.88 | 375 | 16,080 | 70,729 | Dec 17, 2021, 05:10 PM |
| Machiels Alec | Director | Dec 15, 2021 | Option Exercise | $2.67 | 3,000 | 8,010 | 672,544 | Dec 17, 2021, 05:09 PM |
| Machiels Alec | Director | Dec 15, 2021 | Sale | $42.88 | 3,000 | 128,640 | 669,544 | Dec 17, 2021, 05:09 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Dec 08, 2021 | Option Exercise | $3.76 | 7,000 | 26,320 | 71,104 | Dec 09, 2021, 04:57 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Dec 01, 2021 | Sale | $42.40 | 375 | 15,900 | 64,104 | Dec 03, 2021, 04:00 PM |
| Morningside Venture Investments Ltd | 10% Owner | Nov 18, 2021 | Buy | $40.00 | 250,000 | 10,000,000 | 12,806,342 | Nov 18, 2021, 04:16 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Nov 15, 2021 | Sale | $43.50 | 625 | 27,188 | 64,479 | Nov 17, 2021, 05:02 PM |
| Machiels Alec | Director | Nov 15, 2021 | Option Exercise | $2.67 | 3,000 | 8,010 | 672,544 | Nov 17, 2021, 05:01 PM |
| Machiels Alec | Director | Nov 04, 2021 | Option Exercise | $2.67 | 3,000 | 8,010 | 672,544 | Nov 17, 2021, 05:01 PM |
| Machiels Alec | Director | Nov 04, 2021 | Sale | $35.00 | 3,000 | 105,000 | 669,544 | Nov 17, 2021, 05:01 PM |
| Machiels Alec | Director | Nov 15, 2021 | Sale | $43.50 | 3,000 | 130,500 | 669,544 | Nov 17, 2021, 05:01 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Nov 01, 2021 | Sale | $30.70 | 625 | 19,188 | 64,805 | Nov 02, 2021, 04:01 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Oct 14, 2021 | Sale | $34.57 | 750 | 25,927 | 65,430 | Oct 15, 2021, 04:02 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Oct 01, 2021 | Sale | $33.26 | 750 | 24,945 | 66,180 | Oct 05, 2021, 04:16 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Sep 28, 2021 | Option Exercise | $3.76 | 4,000 | 15,040 | 66,930 | Sep 29, 2021, 09:48 PM |
| Dunlop A. Sinclair | Director | Sep 10, 2021 | Option Exercise | $14.00 | 6,894 | 96,516 | 66,894 | Sep 13, 2021, 04:10 PM |
| Watson David O. | General Counsel | Sep 10, 2021 | Option Exercise | $4.31 | 954 | 4,112 | 99,193 | Sep 13, 2021, 04:08 PM |
| Machiels Alec | Director | Aug 16, 2021 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Aug 17, 2021, 04:42 PM |
| Machiels Alec | Director | Aug 16, 2021 | Sale | $56.95 | 2,500 | 142,375 | 669,544 | Aug 17, 2021, 04:42 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Aug 02, 2021 | Sale | $63.99 | 250 | 15,998 | 62,930 | Aug 03, 2021, 04:26 PM |
| Perry Nicole D | Vice President - Accounting | Aug 02, 2021 | Option Exercise | $3.76 | 1,000 | 3,760 | 5,847 | Aug 03, 2021, 04:23 PM |
| Perry Nicole D | Vice President - Accounting | Aug 02, 2021 | Sale | $63.99 | 1,000 | 63,990 | 4,847 | Aug 03, 2021, 04:23 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jul 21, 2021 | Option Exercise | $15.52 | 1,000 | 15,520 | 10,490 | Jul 22, 2021, 04:24 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jul 21, 2021 | Sale | $65.00 | 1,000 | 65,000 | 9,490 | Jul 22, 2021, 04:24 PM |
| Francois Cedric | Chief Executive Officer | Jul 21, 2021 | Option Exercise | $4.31 | 14,410 | 62,107 | 1,234,243 | Jul 22, 2021, 04:04 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jul 15, 2021 | Option Exercise | $15.52 | 1,000 | 15,520 | 10,490 | Jul 16, 2021, 06:40 PM |
| DeLong Mark Jeffrey | Senior Vice President | Jul 15, 2021 | Sale | $62.30 | 1,000 | 62,300 | 9,490 | Jul 16, 2021, 06:40 PM |
| Machiels Alec | Director | Jul 15, 2021 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Jul 16, 2021, 06:38 PM |
| Machiels Alec | Director | Jul 15, 2021 | Sale | $62.30 | 2,500 | 155,750 | 669,544 | Jul 16, 2021, 06:38 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jul 14, 2021 | Sale | $64.68 | 500 | 32,340 | 63,180 | Jul 15, 2021, 04:56 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jul 08, 2021 | Sale | $65.68 | 250 | 16,420 | 63,680 | Jul 09, 2021, 03:59 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jun 28, 2021 | Option Exercise | $3.76 | 9,000 | 33,840 | 63,930 | Jun 29, 2021, 04:58 PM |
| Deschatelets Pascal | Chief Scientific Officer | Jun 24, 2021 | Option Exercise | $2.67 | 6,250 | 16,688 | 875,837 | Jun 25, 2021, 09:48 PM |
| Deschatelets Pascal | Chief Scientific Officer | Jun 24, 2021 | Sale | $65.61 | 6,250 | 410,063 | 869,587 | Jun 25, 2021, 09:48 PM |
| Machiels Alec | Director | Jun 15, 2021 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Jun 16, 2021, 04:33 PM |
| Machiels Alec | Director | Jun 15, 2021 | Sale | $64.83 | 2,500 | 162,075 | 669,544 | Jun 16, 2021, 04:33 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jun 14, 2021 | Sale | $61.84 | 500 | 30,920 | 54,930 | Jun 15, 2021, 04:03 PM |
| Machiels Alec | Director | May 14, 2021 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | May 18, 2021, 04:05 PM |
| Machiels Alec | Director | May 14, 2021 | Sale | $45.39 | 2,500 | 113,475 | 669,544 | May 18, 2021, 04:05 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | May 03, 2021 | Sale | $50.73 | 600 | 30,438 | 55,614 | May 04, 2021, 04:11 PM |
| Deschatelets Pascal | Chief Scientific Officer | Apr 28, 2021 | Option Exercise | $2.67 | 4,500 | 12,015 | 869,587 | Apr 29, 2021, 05:11 PM |
| Deschatelets Pascal | Chief Scientific Officer | Apr 23, 2021 | Option Exercise | $2.67 | 6,250 | 16,688 | 871,337 | Apr 26, 2021, 06:02 PM |
| Deschatelets Pascal | Chief Scientific Officer | Apr 23, 2021 | Sale | $46.13 | 6,250 | 288,313 | 865,087 | Apr 26, 2021, 06:02 PM |
| Watson David O. | General Counsel | Apr 22, 2021 | Option Exercise | $4.31 | 489 | 2,108 | 97,261 | Apr 23, 2021, 04:02 PM |
| Machiels Alec | Director | Apr 21, 2021 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Apr 22, 2021, 06:17 PM |
| Machiels Alec | Director | Apr 21, 2021 | Sale | $45.76 | 2,500 | 114,400 | 669,544 | Apr 22, 2021, 06:17 PM |
| Dunlop A. Sinclair | Director | Apr 16, 2021 | Option Exercise | $14.00 | 50,000 | 700,000 | 50,000 | Apr 19, 2021, 07:29 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Apr 14, 2021 | Sale | $42.82 | 500 | 21,410 | 56,214 | Apr 15, 2021, 05:55 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Apr 01, 2021 | Sale | $43.41 | 600 | 26,046 | 56,714 | Apr 05, 2021, 05:11 PM |
| Brown Victoria L. | Program Team Lead | Mar 25, 2021 | Option Exercise | $41.16 | 82 | 3,375 | 9,952 | Mar 29, 2021, 04:58 PM |
| Watson David O. | General Counsel | Mar 22, 2021 | Option Exercise | $4.31 | 978 | 4,215 | 96,772 | Mar 23, 2021, 04:14 PM |
| Machiels Alec | Director | Mar 15, 2021 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Mar 17, 2021, 04:16 PM |
| Machiels Alec | Director | Mar 15, 2021 | Sale | $46.77 | 2,500 | 116,925 | 669,544 | Mar 17, 2021, 04:16 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Mar 15, 2021 | Sale | $46.77 | 500 | 23,385 | 57,314 | Mar 17, 2021, 04:14 PM |
| Deschatelets Pascal | Chief Scientific Officer | Mar 10, 2021 | Option Exercise | $2.67 | 6,250 | 16,688 | 871,337 | Mar 11, 2021, 04:08 PM |
| Deschatelets Pascal | Chief Scientific Officer | Mar 10, 2021 | Sale | $50.74 | 6,250 | 317,125 | 865,087 | Mar 11, 2021, 04:08 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Mar 05, 2021 | Option Exercise | $3.20 | 5,000 | 16,000 | 62,814 | Mar 08, 2021, 04:32 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Mar 05, 2021 | Sale | $48.62 | 5,000 | 243,075 | 57,814 | Mar 08, 2021, 04:32 PM |
| Perry Nicole D | Vice President - Accounting | Mar 01, 2021 | Option Exercise | $3.76 | 2,000 | 7,520 | 4,347 | Mar 03, 2021, 04:05 PM |
| Perry Nicole D | Vice President - Accounting | Mar 01, 2021 | Sale | $50.00 | 2,000 | 100,000 | 2,347 | Mar 03, 2021, 04:05 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Mar 01, 2021 | Sale | $48.58 | 600 | 29,148 | 57,814 | Mar 03, 2021, 04:03 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Feb 16, 2021 | Sale | $46.00 | 500 | 23,000 | 58,414 | Feb 17, 2021, 04:12 PM |
| Machiels Alec | Director | Feb 16, 2021 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Feb 17, 2021, 04:11 PM |
| Machiels Alec | Director | Feb 16, 2021 | Sale | $46.00 | 2,500 | 115,000 | 669,544 | Feb 17, 2021, 04:11 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Feb 10, 2021 | Option Exercise | $47.72 | 680 | 32,450 | 29,290 | Feb 11, 2021, 04:18 PM |
| Sullivan Timothy Eugene | Chief Financial Officer | Feb 10, 2021 | Option Exercise | $47.72 | 858 | 40,944 | 34,261 | Feb 11, 2021, 04:16 PM |
| Perry Nicole D | Vice President - Accounting | Feb 10, 2021 | Option Exercise | $47.72 | 153 | 7,301 | 2,347 | Feb 11, 2021, 04:14 PM |
| Deschatelets Pascal | Chief Scientific Officer | Feb 10, 2021 | Option Exercise | $47.72 | 688 | 32,831 | 865,087 | Feb 11, 2021, 04:12 PM |
| Townsend Adam J. | Chief Commercial Officer | Feb 10, 2021 | Option Exercise | $47.72 | 688 | 32,831 | 18,865 | Feb 11, 2021, 04:10 PM |
| Brown Victoria L. | Program Team Lead | Feb 10, 2021 | Option Exercise | $47.72 | 144 | 6,872 | 8,784 | Feb 11, 2021, 04:07 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Feb 10, 2021 | Option Exercise | $47.72 | 688 | 32,831 | 58,914 | Feb 11, 2021, 04:06 PM |
| Francois Cedric | Chief Executive Officer | Feb 10, 2021 | Option Exercise | $47.72 | 2,523 | 120,398 | 1,219,833 | Feb 11, 2021, 04:05 PM |
| Francois Cedric | Chief Executive Officer | Feb 10, 2021 | Option Exercise | $47.72 | 2,523 | 120,398 | 1,219,833 | Feb 11, 2021, 04:05 PM |
| Watson David O. | General Counsel | Feb 10, 2021 | Option Exercise | $47.72 | 468 | 22,333 | 95,794 | Feb 11, 2021, 04:02 PM |
| Perry Nicole D | Vice President - Accounting | Feb 09, 2021 | Option Exercise | $3.76 | 2,000 | 7,520 | 4,500 | Feb 10, 2021, 04:37 PM |
| Perry Nicole D | Vice President - Accounting | Feb 09, 2021 | Sale | $50.00 | 2,000 | 100,000 | 2,500 | Feb 10, 2021, 04:37 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Feb 01, 2021 | Sale | $44.00 | 600 | 26,400 | 59,602 | Feb 02, 2021, 04:08 PM |
| Francois Cedric | Chief Executive Officer | Jan 27, 2021 | Option Exercise | $4.01 | 71,777 | 287,477 | 1,184,856 | Jan 29, 2021, 04:19 PM |
| Watson David O. | General Counsel | Jan 27, 2021 | Option Exercise | $4.01 | 43,483 | 174,519 | 86,887 | Jan 29, 2021, 04:18 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jan 25, 2021 | Option Exercise | $3.63 | 15,000 | 54,440 | 50,827 | Jan 26, 2021, 04:25 PM |
| Machiels Alec | Director | Jan 15, 2021 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Jan 19, 2021, 04:05 PM |
| Machiels Alec | Director | Jan 15, 2021 | Sale | $53.15 | 2,500 | 132,875 | 669,544 | Jan 19, 2021, 04:05 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jan 14, 2021 | Sale | $51.99 | 4,000 | 207,960 | 35,827 | Jan 15, 2021, 04:10 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Jan 04, 2021 | Sale | $57.24 | 600 | 34,344 | 39,827 | Jan 05, 2021, 04:21 PM |
| Perry Nicole D | Vice President - Accounting | Jan 04, 2021 | Option Exercise | $3.76 | 2,000 | 7,520 | 2,000 | Jan 05, 2021, 12:00 AM |
| Perry Nicole D | Vice President - Accounting | Jan 04, 2021 | Sale | $57.24 | 2,000 | 114,480 | 0 | Jan 05, 2021, 12:00 AM |
| Machiels Alec | Director | Dec 15, 2020 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Dec 16, 2020, 04:36 PM |
| Machiels Alec | Director | Dec 15, 2020 | Sale | $52.16 | 2,500 | 130,400 | 669,544 | Dec 16, 2020, 04:36 PM |
| Francois Cedric | Chief Executive Officer | Dec 15, 2020 | Sale | $52.16 | 5,000 | 260,800 | 1,113,079 | Dec 16, 2020, 04:35 PM |
| Dunlop A. Sinclair | Director | Dec 14, 2020 | Sale | $54.67 | 25,000 | 1,366,713 | 192,074 | Dec 15, 2020, 05:05 PM |
| Watson David O. | General Counsel | Dec 11, 2020 | Option Exercise | $13.85 | 9,935 | 137,600 | 53,339 | Dec 15, 2020, 04:03 PM |
| Watson David O. | General Counsel | Dec 14, 2020 | Option Exercise | $13.85 | 8,398 | 116,312 | 51,802 | Dec 15, 2020, 04:03 PM |
| Watson David O. | General Counsel | Dec 14, 2020 | Sale | $52.06 | 8,398 | 437,197 | 49,093 | Dec 15, 2020, 04:03 PM |
| Watson David O. | General Counsel | Dec 11, 2020 | Sale | $50.00 | 9,935 | 496,750 | 43,404 | Dec 15, 2020, 04:03 PM |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | Dec 08, 2020 | Option Exercise | $26.73 | 7,482 | 199,994 | 20,595 | Dec 09, 2020, 05:34 PM |
| Perry Nicole D | Vice President - Accounting | Dec 04, 2020 | Option Exercise | $3.76 | 18,000 | 67,680 | 18,000 | Dec 08, 2020, 07:32 PM |
| Perry Nicole D | Vice President - Accounting | Dec 04, 2020 | Sale | $50.00 | 18,000 | 900,000 | 0 | Dec 08, 2020, 07:32 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Dec 04, 2020 | Option Exercise | $3.20 | 7,250 | 23,200 | 40,427 | Dec 08, 2020, 07:21 PM |
| Dunlop A. Sinclair | Director | Dec 07, 2020 | Sale | $50.71 | 18,564 | 941,399 | 209,198 | Dec 07, 2020, 06:58 PM |
| Dunlop A. Sinclair | Director | Dec 04, 2020 | Sale | $50.26 | 6,436 | 323,455 | 219,676 | Dec 07, 2020, 06:58 PM |
| Francois Cedric | Chief Executive Officer | Dec 01, 2020 | Option Exercise | $3.76 | 40,000 | 150,400 | 1,118,079 | Dec 02, 2020, 04:31 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Dec 01, 2020 | Sale | $48.25 | 600 | 28,950 | 33,177 | Dec 02, 2020, 04:30 PM |
| Francois Cedric | Chief Executive Officer | Nov 16, 2020 | Sale | $39.38 | 5,000 | 196,900 | 1,078,079 | Nov 17, 2020, 07:13 PM |
| Machiels Alec | Director | Nov 16, 2020 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Nov 17, 2020, 07:12 PM |
| Machiels Alec | Director | Nov 16, 2020 | Sale | $39.38 | 2,500 | 98,450 | 669,544 | Nov 17, 2020, 07:12 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Nov 16, 2020 | Option Exercise | $3.20 | 5,750 | 18,400 | 33,777 | Nov 17, 2020, 07:11 PM |
| Grossi Federico | CHIEF MEDICAL OFFICER | Nov 02, 2020 | Sale | $31.09 | 600 | 18,654 | 27,725 | Nov 03, 2020, 04:01 PM |
| Machiels Alec | Director | Oct 15, 2020 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Oct 16, 2020, 05:56 PM |
| Machiels Alec | Director | Oct 15, 2020 | Sale | $35.00 | 2,500 | 87,500 | 669,544 | Oct 16, 2020, 05:56 PM |
| Francois Cedric | Chief Executive Officer | Oct 15, 2020 | Sale | $34.46 | 5,000 | 172,300 | 1,083,079 | Oct 16, 2020, 05:31 PM |
| Machiels Alec | Director | Oct 07, 2020 | Option Exercise | $2.67 | 7,500 | 20,025 | 677,044 | Oct 09, 2020, 04:48 PM |
| Machiels Alec | Director | Oct 07, 2020 | Sale | $35.00 | 7,500 | 262,500 | 669,544 | Oct 09, 2020, 04:48 PM |
| Brown Victoria L. | Program Team Lead | Oct 07, 2020 | Option Exercise | $18.98 | 12,000 | 227,760 | 15,607 | Oct 09, 2020, 04:45 PM |
| Brown Victoria L. | Program Team Lead | Oct 07, 2020 | Sale | $35.00 | 12,000 | 420,000 | 3,607 | Oct 09, 2020, 04:45 PM |
| Grossi Federico | See Remarks | Oct 01, 2020 | Sale | $30.22 | 600 | 18,132 | 28,325 | Oct 02, 2020, 04:14 PM |
| Francois Cedric | Chief Executive Officer | Sep 15, 2020 | Sale | $30.96 | 5,000 | 154,800 | 1,088,079 | Sep 16, 2020, 04:03 PM |
| Grossi Federico | See Remarks | Sep 01, 2020 | Sale | $31.58 | 600 | 18,948 | 28,925 | Sep 02, 2020, 04:36 PM |
| Francois Cedric | Chief Executive Officer | Aug 20, 2020 | Sale | $30.00 | 3,457 | 103,710 | 1,093,079 | Aug 21, 2020, 04:36 PM |
| Francois Cedric | Chief Executive Officer | Aug 18, 2020 | Sale | $30.00 | 1,543 | 46,290 | 1,096,536 | Aug 20, 2020, 04:45 PM |
| Grossi Federico | See Remarks | Aug 03, 2020 | Sale | $26.28 | 600 | 15,768 | 29,525 | Aug 05, 2020, 04:37 PM |
| Francois Cedric | Chief Executive Officer | Jul 15, 2020 | Sale | $32.12 | 5,000 | 160,600 | 1,098,079 | Jul 16, 2020, 04:07 PM |
| Grossi Federico | See Remarks | Jul 01, 2020 | Sale | $32.43 | 850 | 27,566 | 30,125 | Jul 02, 2020, 05:48 PM |
| Grossi Federico | See Remarks | Jun 15, 2020 | Sale | $30.21 | 856 | 25,860 | 30,975 | Jun 16, 2020, 04:41 PM |
| Machiels Alec | Director | Jun 15, 2020 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Jun 16, 2020, 04:40 PM |
| Machiels Alec | Director | Jun 15, 2020 | Sale | $30.21 | 2,500 | 75,525 | 669,544 | Jun 16, 2020, 04:40 PM |
| Francois Cedric | Chief Executive Officer | Jun 15, 2020 | Sale | $30.21 | 5,000 | 151,050 | 1,103,079 | Jun 16, 2020, 04:39 PM |
| Francois Cedric | Chief Executive Officer | May 15, 2020 | Sale | $29.92 | 5,000 | 149,600 | 1,108,079 | May 19, 2020, 04:27 PM |
| Machiels Alec | Director | May 15, 2020 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | May 19, 2020, 04:27 PM |
| Machiels Alec | Director | May 15, 2020 | Sale | $30.00 | 2,500 | 75,000 | 669,544 | May 19, 2020, 04:27 PM |
| FONTEYNE PAUL R. | Director | May 08, 2020 | Buy | $31.81 | 5,000 | 159,034 | 5,000 | May 12, 2020, 05:53 PM |
| Francois Cedric | Chief Executive Officer | Apr 15, 2020 | Sale | $29.77 | 5,000 | 148,850 | 1,113,079 | Apr 17, 2020, 07:32 PM |
| Machiels Alec | Director | Apr 15, 2020 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Apr 17, 2020, 07:28 PM |
| Machiels Alec | Director | Apr 15, 2020 | Sale | $30.00 | 2,500 | 75,000 | 669,544 | Apr 17, 2020, 07:28 PM |
| Machiels Alec | Director | Mar 25, 2020 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Mar 26, 2020, 04:01 PM |
| Machiels Alec | Director | Mar 25, 2020 | Sale | $30.00 | 2,500 | 75,000 | 669,544 | Mar 26, 2020, 04:01 PM |
| Francois Cedric | Chief Executive Officer | Mar 16, 2020 | Option Exercise | $2.14 | 30,637 | 65,563 | 1,088,704 | Mar 18, 2020, 04:51 PM |
| Francois Cedric | Chief Executive Officer | Mar 17, 2020 | Option Exercise | $2.14 | 30,637 | 65,563 | 1,083,704 | Mar 18, 2020, 04:51 PM |
| Francois Cedric | Chief Executive Officer | Mar 16, 2020 | Sale | $21.32 | 35,637 | 759,934 | 1,086,596 | Mar 18, 2020, 04:51 PM |
| Francois Cedric | Chief Executive Officer | Feb 19, 2020 | Option Exercise | $2.14 | 30,637 | 65,563 | 1,058,067 | Feb 20, 2020, 04:07 PM |
| Francois Cedric | Chief Executive Officer | Feb 18, 2020 | Option Exercise | $2.14 | 30,637 | 65,563 | 1,063,067 | Feb 20, 2020, 04:07 PM |
| Francois Cedric | Chief Executive Officer | Feb 18, 2020 | Sale | $40.66 | 35,637 | 1,449,122 | 1,032,430 | Feb 20, 2020, 04:07 PM |
| Machiels Alec | Director | Feb 14, 2020 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Feb 19, 2020, 12:00 AM |
| Machiels Alec | Director | Feb 14, 2020 | Sale | $42.35 | 2,500 | 105,875 | 669,544 | Feb 19, 2020, 12:00 AM |
| Deschatelets Pascal | Chief Operating Officer | Feb 12, 2020 | Option Exercise | $2.14 | 117,206 | 250,821 | 998,949 | Feb 14, 2020, 04:49 PM |
| Deschatelets Pascal | Chief Operating Officer | Feb 13, 2020 | Option Exercise | $2.14 | 117,205 | 250,819 | 1,064,079 | Feb 14, 2020, 04:49 PM |
| Deschatelets Pascal | Chief Operating Officer | Feb 13, 2020 | Sale | $40.98 | 55,398 | 2,270,155 | 1,008,681 | Feb 14, 2020, 04:49 PM |
| Deschatelets Pascal | Chief Operating Officer | Feb 12, 2020 | Sale | $42.80 | 52,075 | 2,228,966 | 946,874 | Feb 14, 2020, 04:49 PM |
| Watson David O. | General Counsel | Feb 10, 2020 | Option Exercise | $2.67 | 7,505 | 20,038 | 42,922 | Feb 12, 2020, 04:38 PM |
| Watson David O. | General Counsel | Feb 10, 2020 | Sale | $44.50 | 5,000 | 222,500 | 35,417 | Feb 12, 2020, 04:38 PM |
| Watson David O. | General Counsel | Jan 27, 2020 | Option Exercise | $2.67 | 15,000 | 40,050 | 34,042 | Jan 28, 2020, 05:08 PM |
| Watson David O. | General Counsel | Jan 27, 2020 | Sale | $40.47 | 3,000 | 121,401 | 19,042 | Jan 28, 2020, 05:08 PM |
| Morningside Venture Investments Ltd | 10% Owner | Jan 13, 2020 | Buy | $37.00 | 540,540 | 19,999,980 | 12,556,342 | Jan 21, 2020, 05:47 PM |
| Francois Cedric | Chief Executive Officer | Jan 16, 2020 | Option Exercise | $2.14 | 30,637 | 65,563 | 1,032,430 | Jan 21, 2020, 09:22 AM |
| Francois Cedric | Chief Executive Officer | Jan 15, 2020 | Option Exercise | $2.14 | 30,638 | 65,565 | 1,001,793 | Jan 17, 2020, 04:11 PM |
| Francois Cedric | Chief Executive Officer | Jan 15, 2020 | Sale | $42.11 | 35,638 | 1,500,788 | 1,011,355 | Jan 17, 2020, 04:11 PM |
| Machiels Alec | Director | Jan 15, 2020 | Option Exercise | $2.67 | 2,500 | 6,675 | 672,044 | Jan 17, 2020, 04:08 PM |
| Machiels Alec | Director | Jan 15, 2020 | Sale | $41.47 | 2,500 | 103,675 | 669,544 | Jan 17, 2020, 04:08 PM |
| Dunlop A. Sinclair | Director | Dec 20, 2019 | Sale | $29.53 | 25,000 | 738,250 | 224,728 | Dec 20, 2019, 05:11 PM |
| Dunlop A. Sinclair | Director | Dec 19, 2019 | Sale | $29.18 | 85,110 | 2,483,459 | 320,681 | Dec 20, 2019, 05:11 PM |
| Dunlop A. Sinclair | Director | Dec 18, 2019 | Sale | $28.55 | 25,890 | 739,159 | 374,791 | Dec 20, 2019, 05:11 PM |
| Francois Cedric | Chief Executive Officer | Dec 16, 2019 | Sale | $27.95 | 5,000 | 139,750 | 1,006,793 | Dec 17, 2019, 04:47 PM |
| Francois Cedric | Chief Executive Officer | Nov 15, 2019 | Sale | $27.28 | 5,000 | 136,405 | 1,011,793 | Nov 18, 2019, 04:21 PM |
| Francois Cedric | Chief Executive Officer | Oct 15, 2019 | Sale | $26.31 | 5,000 | 131,551 | 1,020,317 | Oct 16, 2019, 04:02 PM |
| Deschatelets Pascal | Chief Operating Officer | Sep 25, 2019 | Sale | $25.26 | 21,541 | 544,059 | 882,753 | Sep 26, 2019, 04:06 PM |
| Deschatelets Pascal | Chief Operating Officer | Sep 24, 2019 | Sale | $24.58 | 21,602 | 531,081 | 904,579 | Sep 25, 2019, 04:26 PM |
| Deschatelets Pascal | Chief Operating Officer | Sep 23, 2019 | Sale | $25.07 | 20,858 | 522,915 | 924,986 | Sep 25, 2019, 04:26 PM |
| Francois Cedric | Chief Executive Officer | Sep 16, 2019 | Sale | $26.59 | 5,000 | 132,949 | 1,022,053 | Sep 17, 2019, 07:29 PM |
| Sullivan Timothy Eugene | Chief Financial Officer | Aug 29, 2019 | Buy | $29.71 | 11,699 | 347,630 | 11,699 | Sep 03, 2019, 04:13 PM |
| Francois Cedric | Chief Executive Officer | Aug 23, 2019 | Option Exercise | $2.67 | 37,505 | 100,138 | 1,026,793 | Aug 26, 2019, 04:10 PM |
| Francois Cedric | Chief Executive Officer | Aug 15, 2019 | Option Exercise | $2.14 | 10,000 | 21,400 | 999,288 | Aug 16, 2019, 04:08 PM |
| Francois Cedric | Chief Executive Officer | Aug 15, 2019 | Sale | $26.80 | 10,000 | 268,007 | 991,534 | Aug 16, 2019, 04:08 PM |
| Watson David O. | General Counsel | Aug 07, 2019 | Option Exercise | $2.67 | 5,000 | 13,350 | 22,042 | Aug 09, 2019, 08:48 AM |
| Francois Cedric | Chief Executive Officer | Jun 27, 2019 | Option Exercise | $2.14 | 275,000 | 588,500 | 989,288 | Jul 01, 2019, 04:09 PM |
| Morningside Venture Investments Ltd | 10% Owner | Mar 11, 2019 | Buy | $17.00 | 441,176 | 7,499,992 | 12,015,802 | Mar 13, 2019, 03:32 PM |
| Grossi Federico | See Remarks | Nov 14, 2018 | Option Exercise | $3.20 | 6,250 | 20,000 | 22,456 | Nov 15, 2018, 08:45 PM |
| Axon Steven | Chief Business Officer | Nov 14, 2018 | Option Exercise | $2.59 | 11,500 | 29,785 | 50,110 | Nov 15, 2018, 08:40 PM |
| Morningside Venture Investments Ltd | 10% Owner | Sep 21, 2018 | Buy | $19.84 | 40,000 | 793,600 | 11,574,626 | Sep 24, 2018, 06:05 PM |
| Morningside Venture Investments Ltd | 10% Owner | Sep 20, 2018 | Buy | $19.13 | 41,323 | 790,363 | 11,534,626 | Sep 24, 2018, 06:05 PM |
| Morningside Venture Investments Ltd | 10% Owner | Sep 19, 2018 | Buy | $18.09 | 60,000 | 1,085,400 | 11,493,303 | Sep 19, 2018, 07:42 PM |
| Morningside Venture Investments Ltd | 10% Owner | Sep 18, 2018 | Buy | $18.47 | 40,000 | 738,800 | 11,433,303 | Sep 19, 2018, 07:42 PM |
| Morningside Venture Investments Ltd | 10% Owner | Sep 17, 2018 | Buy | $18.57 | 40,000 | 742,924 | 11,393,303 | Sep 19, 2018, 07:42 PM |
| Watson David O. | General Counsel | Sep 14, 2018 | Option Exercise | $2.67 | 32,818 | 87,624 | 32,818 | Sep 17, 2018, 05:40 PM |
| Watson David O. | General Counsel | Sep 14, 2018 | Sale | $18.78 | 15,776 | 296,336 | 17,042 | Sep 17, 2018, 05:40 PM |
| Watson David O. | General Counsel | May 29, 2018 | Option Exercise | $2.67 | 624 | 1,666 | 624 | May 30, 2018, 08:31 PM |
| SCHEIBLER LUKAS | See Remarks | May 24, 2018 | Buy | $20.37 | 2,935 | 59,786 | 2,935 | May 29, 2018, 04:17 PM |
| Grossi Federico | See Remarks | Apr 11, 2018 | Option Exercise | $3.20 | 8,500 | 27,200 | 8,500 | Apr 12, 2018, 04:08 PM |
| Axon Steven | Chief Business Officer | Feb 20, 2018 | Option Exercise | $2.59 | 38,610 | 100,000 | 38,610 | Feb 21, 2018, 05:13 PM |
| Hillhouse Capital Management, Ltd. | 10% Owner | Nov 13, 2017 | Buy | $14.00 | 1,428,571 | 19,999,994 | 3,527,152 | Nov 15, 2017, 04:32 PM |
| Cormorant Asset Management, LLC | 10% Owner | Nov 13, 2017 | Buy | $14.00 | 1,071,428 | 14,999,992 | 3,473,925 | Nov 14, 2017, 04:31 PM |
| venBio Global Strategic Fund II L.P. | 10% Owner | Nov 13, 2017 | Buy | $14.00 | 127,515 | 1,785,210 | 3,579,305 | Nov 13, 2017, 04:27 PM |
| Morningside Venture Investments Ltd | 10% Owner | Nov 13, 2017 | Buy | $14.00 | 575,000 | 8,050,000 | 11,353,303 | Nov 13, 2017, 04:26 PM |
Load More Insider Transactions
Buy
Sale
Option Exercise
| Owner | Relationship | Date | Value($) |
| Townsend Adam J. | Chief Commercial Officer | 08/11/2022 | 188,625 |
| Townsend Adam J. | Chief Commercial Officer | 08/11/2022 | 837,500 |
| DeLong Mark Jeffrey | Senior Vice President | 08/11/2022 | 77,600 |
| DeLong Mark Jeffrey | Senior Vice President | 08/11/2022 | 335,000 |
| Dunlop A. Sinclair | Director | 08/11/2022 | 1,968,900 |
| Townsend Adam J. | Chief Commercial Officer | 08/08/2022 | 188,625 |
| Townsend Adam J. | Chief Commercial Officer | 08/08/2022 | 812,500 |
| Deschatelets Pascal | Chief Scientific Officer | 08/08/2022 | 49,395 |
| Deschatelets Pascal | Chief Scientific Officer | 08/08/2022 | 750,000 |
| DeLong Mark Jeffrey | Senior Vice President | 08/08/2022 | 77,600 |
| DeLong Mark Jeffrey | Senior Vice President | 08/08/2022 | 322,500 |
| DeLong Mark Jeffrey | Senior Vice President | 08/04/2022 | 155,200 |
| DeLong Mark Jeffrey | Senior Vice President | 08/04/2022 | 607,500 |
| Townsend Adam J. | Chief Commercial Officer | 08/03/2022 | 75,450 |
| Townsend Adam J. | Chief Commercial Officer | 08/03/2022 | 282,150 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 08/01/2022 | 139,975 |
| DeLong Mark Jeffrey | Senior Vice President | 07/27/2022 | 77,600 |
| DeLong Mark Jeffrey | Senior Vice President | 07/27/2022 | 285,000 |
| Dunlop A. Sinclair | Director | 07/21/2022 | 134,484 |
| DeLong Mark Jeffrey | Senior Vice President | 07/19/2022 | 77,600 |
| DeLong Mark Jeffrey | Senior Vice President | 07/19/2022 | 282,100 |
| Machiels Alec | Director | 07/15/2022 | 3,338 |
| Machiels Alec | Director | 07/15/2022 | 57,913 |
| Townsend Adam J. | Chief Commercial Officer | 07/11/2022 | 75,450 |
| Townsend Adam J. | Chief Commercial Officer | 07/11/2022 | 242,100 |
| Deschatelets Pascal | Chief Scientific Officer | 07/08/2022 | 49,395 |
| Deschatelets Pascal | Chief Scientific Officer | 07/08/2022 | 575,400 |
| Dunlop A. Sinclair | Director | 06/27/2022 | 62,743 |
| Dunlop A. Sinclair | Director | 06/23/2022 | 675,000 |
| Watson David O. | General Counsel | 06/22/2022 | 445,140 |
| Deschatelets Pascal | Chief Scientific Officer | 06/17/2022 | 88,123 |
| Brown Victoria L. | Program Team Lead | 06/17/2022 | 121,410 |
| DeLong Mark Jeffrey | Senior Vice President | 06/16/2022 | 138,500 |
| DeLong Mark Jeffrey | Senior Vice President | 06/16/2022 | 417,850 |
| Machiels Alec | Director | 06/15/2022 | 3,338 |
| Machiels Alec | Director | 06/15/2022 | 49,113 |
| Deschatelets Pascal | Chief Scientific Officer | 06/08/2022 | 49,395 |
| Deschatelets Pascal | Chief Scientific Officer | 06/08/2022 | 529,080 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 06/01/2022 | 104,450 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 05/27/2022 | 430,000 |
| Machiels Alec | Director | 05/16/2022 | 3,338 |
| Machiels Alec | Director | 05/16/2022 | 48,975 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 05/02/2022 | 108,900 |
| Deschatelets Pascal | Chief Scientific Officer | 04/29/2022 | 10,680 |
| Deschatelets Pascal | Chief Scientific Officer | 04/29/2022 | 177,720 |
| Watson David O. | General Counsel | 04/25/2022 | 250,000 |
| Dunlop A. Sinclair | Director | 04/22/2022 | 280,000 |
| DeLong Mark Jeffrey | Senior Vice President | 04/20/2022 | 108,640 |
| DeLong Mark Jeffrey | Senior Vice President | 04/20/2022 | 367,710 |
| Machiels Alec | Director | 04/14/2022 | 3,338 |
| Machiels Alec | Director | 04/14/2022 | 63,625 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 04/05/2022 | 8,435 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 04/05/2022 | 36,593 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 04/04/2022 | 48,530 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 04/04/2022 | 199,589 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 04/01/2022 | 159,220 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 04/01/2022 | 632,855 |
| Brown Victoria L. | Program Team Lead | 03/25/2022 | 4,041 |
| Machiels Alec | Director | 03/15/2022 | 3,338 |
| Machiels Alec | Director | 03/15/2022 | 49,462 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 03/15/2022 | 30,170 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 03/15/2022 | 14,839 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 03/01/2022 | 16,324 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 02/23/2022 | 17,671 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 02/15/2022 | 17,036 |
| Machiels Alec | Director | 02/15/2022 | 3,338 |
| Machiels Alec | Director | 02/15/2022 | 56,788 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 02/14/2022 | 15,516 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 02/14/2022 | 19,246 |
| Watson David O. | General Counsel | 02/10/2022 | 23,136 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 02/10/2022 | 33,220 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 02/08/2022 | 138,500 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 02/08/2022 | 450,000 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 02/01/2022 | 15,218 |
| Brown Victoria L. | Program Team Lead | 01/28/2022 | 16,748 |
| DeLong Mark Jeffrey | Senior Vice President | 01/28/2022 | 16,748 |
| Eisele Jeffrey | Exec VP, Program Team Lead | 01/28/2022 | 16,748 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 01/28/2022 | 25,084 |
| Nicholson Nur | Chief Technical Officer | 01/28/2022 | 25,084 |
| Sullivan Timothy Eugene | Chief Financial Officer | 01/28/2022 | 25,084 |
| Watson David O. | General Counsel | 01/28/2022 | 25,084 |
| Townsend Adam J. | Chief Commercial Officer | 01/28/2022 | 30,872 |
| Deschatelets Pascal | Chief Scientific Officer | 01/28/2022 | 35,927 |
| Francois Cedric | Chief Executive Officer | 01/28/2022 | 78,106 |
| Lewis Karen | Chief People Officer | 01/28/2022 | 16,748 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 01/28/2022 | 24,775 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 01/31/2022 | 47,434 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 01/21/2022 | 80,751 |
| Machiels Alec | Director | 01/14/2022 | 3,338 |
| Machiels Alec | Director | 01/14/2022 | 50,700 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 01/14/2022 | 14,654 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 01/14/2022 | 15,210 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 01/12/2022 | 20,230 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 01/03/2022 | 17,741 |
| Watson David O. | General Counsel | 12/27/2021 | 58,200 |
| Watson David O. | General Counsel | 12/22/2021 | 289,674 |
| Watson David O. | General Counsel | 12/22/2021 | 505,373 |
| Eisele Jeffrey | Exec VP, Program Team Lead | 12/22/2021 | 4,256 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 12/15/2021 | 16,080 |
| Machiels Alec | Director | 12/15/2021 | 8,010 |
| Machiels Alec | Director | 12/15/2021 | 128,640 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 12/08/2021 | 26,320 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 12/01/2021 | 15,900 |
| Morningside Venture Investments Ltd | 10% Owner | 11/18/2021 | 10,000,000 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 11/15/2021 | 27,188 |
| Machiels Alec | Director | 11/15/2021 | 8,010 |
| Machiels Alec | Director | 11/04/2021 | 8,010 |
| Machiels Alec | Director | 11/04/2021 | 105,000 |
| Machiels Alec | Director | 11/15/2021 | 130,500 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 11/01/2021 | 19,188 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 10/14/2021 | 25,927 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 10/01/2021 | 24,945 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 09/28/2021 | 15,040 |
| Dunlop A. Sinclair | Director | 09/10/2021 | 96,516 |
| Watson David O. | General Counsel | 09/10/2021 | 4,112 |
| Machiels Alec | Director | 08/16/2021 | 6,675 |
| Machiels Alec | Director | 08/16/2021 | 142,375 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 08/02/2021 | 15,998 |
| Perry Nicole D | Vice President - Accounting | 08/02/2021 | 3,760 |
| Perry Nicole D | Vice President - Accounting | 08/02/2021 | 63,990 |
| DeLong Mark Jeffrey | Senior Vice President | 07/21/2021 | 15,520 |
| DeLong Mark Jeffrey | Senior Vice President | 07/21/2021 | 65,000 |
| Francois Cedric | Chief Executive Officer | 07/21/2021 | 62,107 |
| DeLong Mark Jeffrey | Senior Vice President | 07/15/2021 | 15,520 |
| DeLong Mark Jeffrey | Senior Vice President | 07/15/2021 | 62,300 |
| Machiels Alec | Director | 07/15/2021 | 6,675 |
| Machiels Alec | Director | 07/15/2021 | 155,750 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 07/14/2021 | 32,340 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 07/08/2021 | 16,420 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 06/28/2021 | 33,840 |
| Deschatelets Pascal | Chief Scientific Officer | 06/24/2021 | 16,688 |
| Deschatelets Pascal | Chief Scientific Officer | 06/24/2021 | 410,063 |
| Machiels Alec | Director | 06/15/2021 | 6,675 |
| Machiels Alec | Director | 06/15/2021 | 162,075 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 06/14/2021 | 30,920 |
| Machiels Alec | Director | 05/14/2021 | 6,675 |
| Machiels Alec | Director | 05/14/2021 | 113,475 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 05/03/2021 | 30,438 |
| Deschatelets Pascal | Chief Scientific Officer | 04/28/2021 | 12,015 |
| Deschatelets Pascal | Chief Scientific Officer | 04/23/2021 | 16,688 |
| Deschatelets Pascal | Chief Scientific Officer | 04/23/2021 | 288,313 |
| Watson David O. | General Counsel | 04/22/2021 | 2,108 |
| Machiels Alec | Director | 04/21/2021 | 6,675 |
| Machiels Alec | Director | 04/21/2021 | 114,400 |
| Dunlop A. Sinclair | Director | 04/16/2021 | 700,000 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 04/14/2021 | 21,410 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 04/01/2021 | 26,046 |
| Brown Victoria L. | Program Team Lead | 03/25/2021 | 3,375 |
| Watson David O. | General Counsel | 03/22/2021 | 4,215 |
| Machiels Alec | Director | 03/15/2021 | 6,675 |
| Machiels Alec | Director | 03/15/2021 | 116,925 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 03/15/2021 | 23,385 |
| Deschatelets Pascal | Chief Scientific Officer | 03/10/2021 | 16,688 |
| Deschatelets Pascal | Chief Scientific Officer | 03/10/2021 | 317,125 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 03/05/2021 | 16,000 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 03/05/2021 | 243,075 |
| Perry Nicole D | Vice President - Accounting | 03/01/2021 | 7,520 |
| Perry Nicole D | Vice President - Accounting | 03/01/2021 | 100,000 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 03/01/2021 | 29,148 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 02/16/2021 | 23,000 |
| Machiels Alec | Director | 02/16/2021 | 6,675 |
| Machiels Alec | Director | 02/16/2021 | 115,000 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 02/10/2021 | 32,450 |
| Sullivan Timothy Eugene | Chief Financial Officer | 02/10/2021 | 40,944 |
| Perry Nicole D | Vice President - Accounting | 02/10/2021 | 7,301 |
| Deschatelets Pascal | Chief Scientific Officer | 02/10/2021 | 32,831 |
| Townsend Adam J. | Chief Commercial Officer | 02/10/2021 | 32,831 |
| Brown Victoria L. | Program Team Lead | 02/10/2021 | 6,872 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 02/10/2021 | 32,831 |
| Francois Cedric | Chief Executive Officer | 02/10/2021 | 120,398 |
| Francois Cedric | Chief Executive Officer | 02/10/2021 | 120,398 |
| Watson David O. | General Counsel | 02/10/2021 | 22,333 |
| Perry Nicole D | Vice President - Accounting | 02/09/2021 | 7,520 |
| Perry Nicole D | Vice President - Accounting | 02/09/2021 | 100,000 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 02/01/2021 | 26,400 |
| Francois Cedric | Chief Executive Officer | 01/27/2021 | 287,477 |
| Watson David O. | General Counsel | 01/27/2021 | 174,519 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 01/25/2021 | 54,440 |
| Machiels Alec | Director | 01/15/2021 | 6,675 |
| Machiels Alec | Director | 01/15/2021 | 132,875 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 01/14/2021 | 207,960 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 01/04/2021 | 34,344 |
| Perry Nicole D | Vice President - Accounting | 01/04/2021 | 7,520 |
| Perry Nicole D | Vice President - Accounting | 01/04/2021 | 114,480 |
| Machiels Alec | Director | 12/15/2020 | 6,675 |
| Machiels Alec | Director | 12/15/2020 | 130,400 |
| Francois Cedric | Chief Executive Officer | 12/15/2020 | 260,800 |
| Dunlop A. Sinclair | Director | 12/14/2020 | 1,366,713 |
| Watson David O. | General Counsel | 12/11/2020 | 137,600 |
| Watson David O. | General Counsel | 12/14/2020 | 116,312 |
| Watson David O. | General Counsel | 12/14/2020 | 437,197 |
| Watson David O. | General Counsel | 12/11/2020 | 496,750 |
| SCHEIBLER LUKAS | CHIEF INNOVATION OFFICER | 12/08/2020 | 199,994 |
| Perry Nicole D | Vice President - Accounting | 12/04/2020 | 67,680 |
| Perry Nicole D | Vice President - Accounting | 12/04/2020 | 900,000 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 12/04/2020 | 23,200 |
| Dunlop A. Sinclair | Director | 12/07/2020 | 941,399 |
| Dunlop A. Sinclair | Director | 12/04/2020 | 323,455 |
| Francois Cedric | Chief Executive Officer | 12/01/2020 | 150,400 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 12/01/2020 | 28,950 |
| Francois Cedric | Chief Executive Officer | 11/16/2020 | 196,900 |
| Machiels Alec | Director | 11/16/2020 | 6,675 |
| Machiels Alec | Director | 11/16/2020 | 98,450 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 11/16/2020 | 18,400 |
| Grossi Federico | CHIEF MEDICAL OFFICER | 11/02/2020 | 18,654 |
| Machiels Alec | Director | 10/15/2020 | 6,675 |
| Machiels Alec | Director | 10/15/2020 | 87,500 |
| Francois Cedric | Chief Executive Officer | 10/15/2020 | 172,300 |
| Machiels Alec | Director | 10/07/2020 | 20,025 |
| Machiels Alec | Director | 10/07/2020 | 262,500 |
| Brown Victoria L. | Program Team Lead | 10/07/2020 | 227,760 |
| Brown Victoria L. | Program Team Lead | 10/07/2020 | 420,000 |
| Grossi Federico | See Remarks | 10/01/2020 | 18,132 |
| Francois Cedric | Chief Executive Officer | 09/15/2020 | 154,800 |
| Grossi Federico | See Remarks | 09/01/2020 | 18,948 |
| Francois Cedric | Chief Executive Officer | 08/20/2020 | 103,710 |
| Francois Cedric | Chief Executive Officer | 08/18/2020 | 46,290 |
| Grossi Federico | See Remarks | 08/03/2020 | 15,768 |
| Francois Cedric | Chief Executive Officer | 07/15/2020 | 160,600 |
| Grossi Federico | See Remarks | 07/01/2020 | 27,566 |
| Grossi Federico | See Remarks | 06/15/2020 | 25,860 |
| Machiels Alec | Director | 06/15/2020 | 6,675 |
| Machiels Alec | Director | 06/15/2020 | 75,525 |
| Francois Cedric | Chief Executive Officer | 06/15/2020 | 151,050 |
| Francois Cedric | Chief Executive Officer | 05/15/2020 | 149,600 |
| Machiels Alec | Director | 05/15/2020 | 6,675 |
| Machiels Alec | Director | 05/15/2020 | 75,000 |
| FONTEYNE PAUL R. | Director | 05/08/2020 | 159,034 |
| Francois Cedric | Chief Executive Officer | 04/15/2020 | 148,850 |
| Machiels Alec | Director | 04/15/2020 | 6,675 |
| Machiels Alec | Director | 04/15/2020 | 75,000 |
| Machiels Alec | Director | 03/25/2020 | 6,675 |
| Machiels Alec | Director | 03/25/2020 | 75,000 |
| Francois Cedric | Chief Executive Officer | 03/16/2020 | 65,563 |
| Francois Cedric | Chief Executive Officer | 03/17/2020 | 65,563 |
| Francois Cedric | Chief Executive Officer | 03/16/2020 | 759,934 |
| Francois Cedric | Chief Executive Officer | 02/19/2020 | 65,563 |
| Francois Cedric | Chief Executive Officer | 02/18/2020 | 65,563 |
| Francois Cedric | Chief Executive Officer | 02/18/2020 | 1,449,122 |
| Machiels Alec | Director | 02/14/2020 | 6,675 |
| Machiels Alec | Director | 02/14/2020 | 105,875 |
| Deschatelets Pascal | Chief Operating Officer | 02/12/2020 | 250,821 |
| Deschatelets Pascal | Chief Operating Officer | 02/13/2020 | 250,819 |
| Deschatelets Pascal | Chief Operating Officer | 02/13/2020 | 2,270,155 |
| Deschatelets Pascal | Chief Operating Officer | 02/12/2020 | 2,228,966 |
| Watson David O. | General Counsel | 02/10/2020 | 20,038 |
| Watson David O. | General Counsel | 02/10/2020 | 222,500 |
| Watson David O. | General Counsel | 01/27/2020 | 40,050 |
| Watson David O. | General Counsel | 01/27/2020 | 121,401 |
| Morningside Venture Investments Ltd | 10% Owner | 01/13/2020 | 19,999,980 |
| Francois Cedric | Chief Executive Officer | 01/16/2020 | 65,563 |
| Francois Cedric | Chief Executive Officer | 01/15/2020 | 65,565 |
| Francois Cedric | Chief Executive Officer | 01/15/2020 | 1,500,788 |
| Machiels Alec | Director | 01/15/2020 | 6,675 |
| Machiels Alec | Director | 01/15/2020 | 103,675 |
| Dunlop A. Sinclair | Director | 12/20/2019 | 738,250 |
| Dunlop A. Sinclair | Director | 12/19/2019 | 2,483,459 |
| Dunlop A. Sinclair | Director | 12/18/2019 | 739,159 |
| Francois Cedric | Chief Executive Officer | 12/16/2019 | 139,750 |
| Francois Cedric | Chief Executive Officer | 11/15/2019 | 136,405 |
| Francois Cedric | Chief Executive Officer | 10/15/2019 | 131,551 |
| Deschatelets Pascal | Chief Operating Officer | 09/25/2019 | 544,059 |
| Deschatelets Pascal | Chief Operating Officer | 09/24/2019 | 531,081 |
| Deschatelets Pascal | Chief Operating Officer | 09/23/2019 | 522,915 |
| Francois Cedric | Chief Executive Officer | 09/16/2019 | 132,949 |
| Sullivan Timothy Eugene | Chief Financial Officer | 08/29/2019 | 347,630 |
| Francois Cedric | Chief Executive Officer | 08/23/2019 | 100,138 |
| Francois Cedric | Chief Executive Officer | 08/15/2019 | 21,400 |
| Francois Cedric | Chief Executive Officer | 08/15/2019 | 268,007 |
| Watson David O. | General Counsel | 08/07/2019 | 13,350 |
| Francois Cedric | Chief Executive Officer | 06/27/2019 | 588,500 |
| Morningside Venture Investments Ltd | 10% Owner | 03/11/2019 | 7,499,992 |
| Grossi Federico | See Remarks | 11/14/2018 | 20,000 |
| Axon Steven | Chief Business Officer | 11/14/2018 | 29,785 |
| Morningside Venture Investments Ltd | 10% Owner | 09/21/2018 | 793,600 |
| Morningside Venture Investments Ltd | 10% Owner | 09/20/2018 | 790,363 |
| Morningside Venture Investments Ltd | 10% Owner | 09/19/2018 | 1,085,400 |
| Morningside Venture Investments Ltd | 10% Owner | 09/18/2018 | 738,800 |
| Morningside Venture Investments Ltd | 10% Owner | 09/17/2018 | 742,924 |
| Watson David O. | General Counsel | 09/14/2018 | 87,624 |
| Watson David O. | General Counsel | 09/14/2018 | 296,336 |
| Watson David O. | General Counsel | 05/29/2018 | 1,666 |
| SCHEIBLER LUKAS | See Remarks | 05/24/2018 | 59,786 |
| Grossi Federico | See Remarks | 04/11/2018 | 27,200 |
| Axon Steven | Chief Business Officer | 02/20/2018 | 100,000 |
| Hillhouse Capital Management, Ltd. | 10% Owner | 11/13/2017 | 19,999,994 |
| Cormorant Asset Management, LLC | 10% Owner | 11/13/2017 | 14,999,992 |
| venBio Global Strategic Fund II L.P. | 10% Owner | 11/13/2017 | 1,785,210 |
| Morningside Venture Investments Ltd | 10% Owner | 11/13/2017 | 8,050,000 |
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