Amarin Corp. (AMRN) NASDAQ

$1.47 -0.19 (-11.45%)

Market Cap: $583.20M

As of 05/18/22 04:00 PM EDT. Market closed.

(AMRN)

Amarin Corp. (AMRN) NASDAQ

$1.47 -0.19 (-11.45%)

Market Cap: $583.20M

As of 05/18/22 04:00 PM EDT. Market closed.

Amarin is a rapidly growing, innovative pharmaceutical company leading a new paradigm in cardiovascular disease management. From its scientific research foundation to its focus on clinical trials, and now its commercial expansion, it is evolving and growing. In 2009, Amarin had fewer than twenty employees. Today, with offices in Bridgewater, New Jersey in the United States, Dublin in Ireland, and ... read more

Amarin is a rapidly growing, innovative pharmaceutical company leading a new paradigm in cardiovascular disease management. From its scientific research foundation to its focus on clinical trials, and now its commercial expansion, it is evolving and growing. In 2009, Amarin had fewer than twenty employees. Today, with offices in Bridgewater, New Jersey in the United States, Dublin in Ireland, and Zug in Switzerland, Amarin has approximately 1,000 employees and commercial partners and suppliers around the world. It is committed to rethinking cardiovascular risk through the advancement of scientific understanding of the impact on society of significant residual risk that exists beyond traditional therapies, such as statins for cholesterol management. read less

COMPANY PROFILE
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
John Thero
Full Time Employees
2,021
URL
Address
Shelbourne Road Ballsbridge, First Floor Block 3 The Oval, DUBLIN.
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
John Thero
Full Time Employees
2,021
Address
Shelbourne Road Ballsbridge, First Floor Block 3 The Oval, DUBLIN.
PRICE CHART
1w
1m
3m
6m
YTD
1y
5y
MAX
From: To:
KEY STATS
Open
$0
Previous Close
$1.66
Days Range
$1.46 - $1.62
52 week range
$1.11 - $5.97
Volume
190,948
Avg. Volume (30 days)
7,071,148
Market Cap
$583.20M
Dividend Yield
0.00%
P/E
-
Shares Outstanding
396,737,811
Open
$0
Previous Close
$1.66
Days Range
$1.46 - $1.62
52 week range
$1.11 - $5.97
Volume
190,948
Avg. Volume (30 days)
7,071,148
Market Cap
$583.20M
Dividend Yield
0.00%
P/E
-
Shares Outstanding
396,737,811

Open in: SeekingAlpha Yahoo Finance Fidelity MorningStar

Open in: SeekingAlpha Yahoo Finance Fidelity MorningStar

INSIDER TRANSACTIONS FOR AMARIN CORP
Owner Relationship Date Transaction Cost # Shares Value($) Total Shares Form 4
Mikhail Karim President and CEO Apr 12, 2022 Option Exercise $3.35 20,631 69,114 82,134 Apr 14, 2022, 08:02 PM
Kalb Michael Wayne SVP and CFO Feb 28, 2022 Option Exercise $3.27 6,213 20,317 250,747 Mar 02, 2022, 08:03 PM
Ketchum Steven B Chief Scientific Officer Feb 28, 2022 Option Exercise $3.27 5,508 18,011 496,912 Mar 02, 2022, 08:01 PM
Kalb Michael Wayne SVP and CFO Jan 31, 2022 Option Exercise $3.36 5,317 17,865 240,627 Feb 02, 2022, 08:03 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2022 Option Exercise $3.36 5,121 17,207 486,087 Feb 02, 2022, 08:01 PM
Kalb Michael Wayne SVP and CFO Dec 31, 2021 Option Exercise $3.35 25,379 85,020 233,211 Jan 04, 2022, 09:08 PM
Mikhail Karim President and CEO Dec 31, 2021 Option Exercise $3.35 3,876 12,985 31,031 Jan 04, 2022, 09:06 PM
Zakrzewski Joseph S Director Dec 14, 2021 Buy $3.27 10,000 32,689 194,547 Dec 16, 2021, 08:01 PM
Zakrzewski Joseph S Director Dec 15, 2021 Buy $3.15 2,000 6,310 196,547 Dec 16, 2021, 08:01 PM
Berg Aaron EVP, President US Aug 31, 2021 Option Exercise $5.54 3,011 16,681 315,251 Sep 02, 2021, 08:07 PM
Kalb Michael Wayne SVP and CFO Aug 31, 2021 Option Exercise $5.54 3,011 16,681 208,107 Sep 02, 2021, 08:04 PM
Ketchum Steven B Chief Scientific Officer Aug 31, 2021 Option Exercise $5.54 3,127 17,324 455,141 Sep 02, 2021, 08:01 PM
Kalb Michael Wayne SVP and CFO Aug 12, 2021 Option Exercise $2.35 120,000 281,800 325,010 Aug 13, 2021, 08:04 PM
Kalb Michael Wayne SVP and CFO Aug 12, 2021 Sale $5.25 120,000 630,240 205,010 Aug 13, 2021, 08:04 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 30, 2021 Option Exercise $4.14 3,011 12,466 312,154 Aug 03, 2021, 08:12 PM
Kalb Michael Wayne SVP and CFO Jul 30, 2021 Option Exercise $4.14 3,011 12,466 205,010 Aug 03, 2021, 08:10 PM
Ketchum Steven B Chief Scientific Officer Jul 30, 2021 Option Exercise $4.14 3,127 12,946 452,160 Aug 03, 2021, 08:08 PM
Kennedy Joseph T General Counsel Jul 30, 2021 Option Exercise $4.14 3,803 15,744 317,860 Aug 03, 2021, 08:05 PM
THERO JOHN F President and CEO Jul 30, 2021 Option Exercise $4.14 10,604 43,901 3,252,752 Aug 03, 2021, 08:02 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jun 30, 2021 Option Exercise $4.48 3,011 13,489 309,057 Jul 02, 2021, 08:12 PM
Kalb Michael Wayne SVP and CFO Jun 30, 2021 Option Exercise $4.48 3,011 13,489 201,913 Jul 02, 2021, 08:11 PM
Ketchum Steven B Chief Scientific Officer Jun 30, 2021 Option Exercise $4.48 3,127 14,009 449,179 Jul 02, 2021, 08:09 PM
Kennedy Joseph T General Counsel Jun 30, 2021 Option Exercise $4.48 3,803 17,037 314,443 Jul 02, 2021, 08:07 PM
THERO JOHN F President and CEO Jun 30, 2021 Option Exercise $4.48 10,604 47,506 3,236,412 Jul 02, 2021, 08:04 PM
STACK DAVID M Director Jun 04, 2021 Buy $4.53 10,000 45,350 40,000 Jun 07, 2021, 09:53 PM
STACK DAVID M Director Jun 03, 2021 Buy $4.62 5,000 23,115 30,000 Jun 07, 2021, 09:53 PM
Berg Aaron CHIEF COMMERCIAL OFFICER May 28, 2021 Option Exercise $4.54 3,012 13,674 305,960 May 28, 2021, 08:06 PM
Kalb Michael Wayne SVP and CFO May 28, 2021 Option Exercise $4.54 2,995 13,597 198,816 May 28, 2021, 08:06 PM
Kennedy Joseph T General Counsel May 28, 2021 Option Exercise $4.54 3,803 17,266 311,026 May 28, 2021, 08:03 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Apr 30, 2021 Option Exercise $5.12 15,817 80,960 302,860 Apr 30, 2021, 08:10 PM
Kalb Michael Wayne SVP and CFO Apr 30, 2021 Option Exercise $5.24 2,995 15,694 193,154 Apr 30, 2021, 08:09 PM
Kennedy Joseph T General Counsel Apr 30, 2021 Option Exercise $5.24 3,803 19,928 307,609 Apr 30, 2021, 08:05 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Mar 31, 2021 Option Exercise $6.37 3,012 19,186 286,565 Apr 02, 2021, 08:09 PM
Kalb Michael Wayne SVP and CFO Mar 31, 2021 Option Exercise $6.37 2,995 19,078 190,037 Apr 02, 2021, 08:07 PM
Kennedy Joseph T General Counsel Mar 31, 2021 Option Exercise $6.37 3,803 24,225 304,192 Apr 02, 2021, 08:05 PM
THERO JOHN F President and CEO Mar 31, 2021 Option Exercise $6.37 10,604 67,547 3,187,392 Apr 02, 2021, 08:04 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Feb 26, 2021 Option Exercise $6.74 11,057 74,524 283,465 Mar 01, 2021, 08:06 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Feb 25, 2021 Option Exercise $7.30 43,638 318,557 272,076 Mar 01, 2021, 08:06 PM
Kalb Michael Wayne SVP and CFO Feb 26, 2021 Option Exercise $6.74 11,055 74,511 186,920 Mar 01, 2021, 08:05 PM
Kalb Michael Wayne SVP and CFO Feb 25, 2021 Option Exercise $7.30 43,395 316,784 175,529 Mar 01, 2021, 08:05 PM
Ketchum Steven B Chief Scientific Officer Feb 26, 2021 Option Exercise $6.74 11,483 77,395 437,246 Mar 01, 2021, 08:04 PM
Ketchum Steven B Chief Scientific Officer Feb 25, 2021 Option Exercise $7.30 45,327 330,887 426,283 Mar 01, 2021, 08:04 PM
Kennedy Joseph T General Counsel Feb 26, 2021 Option Exercise $6.74 12,404 83,603 300,775 Mar 01, 2021, 08:03 PM
Kennedy Joseph T General Counsel Feb 25, 2021 Option Exercise $7.30 55,140 402,522 289,621 Mar 01, 2021, 08:03 PM
THERO JOHN F President and CEO Feb 26, 2021 Option Exercise $6.74 33,965 228,924 3,171,052 Mar 01, 2021, 08:02 PM
THERO JOHN F President and CEO Feb 25, 2021 Option Exercise $7.30 153,739 1,122,295 3,118,706 Mar 01, 2021, 08:02 PM
Ketchum Steven B Chief Scientific Officer Feb 01, 2021 Option Exercise $2.53 192,358 485,882 600,724 Feb 03, 2021, 08:02 PM
Ketchum Steven B Chief Scientific Officer Feb 01, 2021 Sale $8.06 217,728 1,754,134 408,366 Feb 03, 2021, 08:02 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jan 29, 2021 Option Exercise $7.50 6,281 47,108 227,100 Jan 29, 2021, 08:05 PM
Kalb Michael Wayne SVP and CFO Jan 29, 2021 Option Exercise $7.50 14,928 111,960 130,310 Jan 29, 2021, 08:04 PM
Ketchum Steven B Chief Scientific Officer Jan 29, 2021 Option Exercise $7.50 21,535 161,513 408,366 Jan 29, 2021, 08:03 PM
Ketchum Steven B Chief Scientific Officer Jan 27, 2021 Option Exercise $2.75 278,237 764,566 809,741 Jan 29, 2021, 08:03 PM
Ketchum Steven B Chief Scientific Officer Jan 27, 2021 Sale $8.01 421,629 3,378,131 531,504 Jan 29, 2021, 08:03 PM
Kennedy Joseph T General Counsel Jan 29, 2021 Option Exercise $7.50 16,711 125,333 240,033 Jan 29, 2021, 08:02 PM
THERO JOHN F President and CEO Jan 29, 2021 Option Exercise $7.50 82,762 620,715 2,881,749 Jan 29, 2021, 08:01 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Dec 31, 2020 Option Exercise $5.23 1,506 7,876 217,592 Jan 05, 2021, 08:05 PM
Kalb Michael Wayne SVP and CFO Dec 31, 2020 Option Exercise $5.23 1,498 7,835 103,449 Jan 05, 2021, 08:04 PM
Ketchum Steven B Chief Scientific Officer Dec 31, 2020 Option Exercise $5.23 1,506 7,876 531,504 Jan 05, 2021, 08:03 PM
Kennedy Joseph T General Counsel Dec 31, 2020 Option Exercise $5.23 1,902 9,947 214,399 Jan 05, 2021, 08:03 PM
THERO JOHN F President and CEO Dec 31, 2020 Option Exercise $5.23 5,302 27,729 2,755,340 Jan 05, 2021, 08:01 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Nov 30, 2020 Option Exercise $4.60 1,506 6,928 216,042 Dec 02, 2020, 08:05 PM
STACK DAVID M Director Nov 30, 2020 Buy $4.86 25,000 121,518 25,000 Dec 02, 2020, 08:05 PM
Kalb Michael Wayne SVP and CFO Nov 30, 2020 Option Exercise $4.60 1,498 6,891 101,891 Dec 02, 2020, 08:04 PM
Ketchum Steven B Chief Scientific Officer Nov 30, 2020 Option Exercise $4.60 1,506 6,928 529,954 Dec 02, 2020, 08:03 PM
Kennedy Joseph T General Counsel Nov 30, 2020 Option Exercise $4.60 1,902 8,749 212,689 Dec 02, 2020, 08:03 PM
THERO JOHN F President and CEO Nov 30, 2020 Option Exercise $4.60 5,302 24,389 2,747,170 Dec 02, 2020, 08:02 PM
THERO JOHN F President and CEO Nov 10, 2020 Option Exercise $3.40 615,261 2,091,887 3,306,405 Nov 12, 2020, 08:01 PM
THERO JOHN F President and CEO Nov 09, 2020 Option Exercise $3.40 134,739 458,113 2,691,144 Nov 12, 2020, 08:01 PM
THERO JOHN F President and CEO Nov 10, 2020 Sale $4.13 153,840 635,975 3,152,565 Nov 12, 2020, 08:01 PM
THERO JOHN F President and CEO Nov 11, 2020 Sale $4.07 413,565 1,681,183 2,739,000 Nov 12, 2020, 08:01 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Oct 30, 2020 Option Exercise $4.86 1,506 7,319 214,492 Nov 03, 2020, 08:28 PM
Kalb Michael Wayne SVP and CFO Oct 30, 2020 Option Exercise $4.86 1,498 7,280 98,471 Nov 03, 2020, 08:27 PM
Ketchum Steven B Chief Scientific Officer Oct 30, 2020 Option Exercise $4.86 1,506 7,319 528,404 Nov 03, 2020, 08:26 PM
Kennedy Joseph T General Counsel Oct 30, 2020 Option Exercise $4.86 1,902 9,244 210,979 Nov 03, 2020, 08:25 PM
Zakrzewski Joseph S Director Oct 21, 2020 Option Exercise $3.40 100,000 340,000 184,547 Oct 22, 2020, 08:03 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Sep 30, 2020 Option Exercise $4.04 1,506 6,084 212,942 Oct 02, 2020, 08:05 PM
Ketchum Steven B Chief Scientific Officer Sep 30, 2020 Option Exercise $4.04 1,506 6,084 526,854 Oct 02, 2020, 08:04 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Aug 31, 2020 Option Exercise $7.36 1,506 11,084 211,392 Sep 02, 2020, 08:07 PM
Kalb Michael Wayne SVP and CFO Aug 31, 2020 Option Exercise $7.36 1,496 11,011 93,857 Sep 02, 2020, 08:06 PM
Ketchum Steven B Chief Scientific Officer Aug 31, 2020 Option Exercise $7.36 1,506 11,084 525,304 Sep 02, 2020, 08:04 PM
Kennedy Joseph T General Counsel Aug 31, 2020 Option Exercise $7.36 1,902 13,999 205,657 Sep 02, 2020, 08:02 PM
THERO JOHN F President and CEO Aug 31, 2020 Option Exercise $7.36 5,302 39,023 2,529,459 Sep 02, 2020, 08:01 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 31, 2020 Option Exercise $6.59 1,508 9,938 209,844 Jul 31, 2020, 08:07 PM
Kalb Michael Wayne SVP and CFO Jul 31, 2020 Option Exercise $6.59 1,498 9,872 92,299 Jul 31, 2020, 08:06 PM
Ketchum Steven B Chief Scientific Officer Jul 31, 2020 Option Exercise $6.59 1,508 9,938 523,756 Jul 31, 2020, 08:05 PM
Kennedy Joseph T General Counsel Jul 31, 2020 Option Exercise $6.59 1,904 12,547 203,949 Jul 31, 2020, 08:04 PM
THERO JOHN F President and CEO Jul 31, 2020 Option Exercise $6.59 5,304 34,953 2,521,289 Jul 31, 2020, 08:03 PM
THERO JOHN F President and CEO Jun 30, 2020 Option Exercise $6.72 5,302 35,629 2,513,121 Jul 02, 2020, 08:38 PM
Kennedy Joseph T General Counsel Jun 30, 2020 Option Exercise $6.72 1,902 12,781 202,243 Jul 02, 2020, 08:38 PM
Ketchum Steven B Chief Scientific Officer Jun 30, 2020 Option Exercise $6.72 1,506 10,120 522,210 Jul 02, 2020, 08:37 PM
Kalb Michael Wayne SVP and CFO Jun 30, 2020 Option Exercise $6.72 1,496 10,053 90,743 Jul 02, 2020, 08:35 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jun 30, 2020 Option Exercise $6.72 1,506 10,120 208,298 Jul 02, 2020, 08:34 PM
Berg Aaron CHIEF COMMERCIAL OFFICER May 29, 2020 Option Exercise $6.86 1,506 10,331 206,750 Jun 02, 2020, 08:09 PM
Kalb Michael Wayne SVP and CFO May 29, 2020 Option Exercise $6.86 1,498 10,276 89,185 Jun 02, 2020, 08:08 PM
Ketchum Steven B Chief Scientific Officer May 29, 2020 Option Exercise $6.86 1,506 10,331 520,662 Jun 02, 2020, 08:08 PM
Kennedy Joseph T General Counsel May 29, 2020 Option Exercise $6.86 1,902 13,048 200,535 Jun 02, 2020, 08:07 PM
THERO JOHN F President and CEO May 29, 2020 Option Exercise $6.86 5,302 36,372 2,504,951 Jun 02, 2020, 08:06 PM
Berg Aaron CHIEF COMMERCIAL OFFICER May 01, 2020 Option Exercise $7.61 12,805 97,446 205,200 May 01, 2020, 08:12 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Apr 30, 2020 Option Exercise $8.26 1,506 12,440 192,005 May 01, 2020, 08:12 PM
Kalb Michael Wayne SVP and CFO Apr 30, 2020 Option Exercise $8.26 1,498 12,373 87,043 May 01, 2020, 08:10 PM
Ketchum Steven B Chief Scientific Officer Apr 30, 2020 Option Exercise $8.26 1,506 12,440 519,112 May 01, 2020, 08:10 PM
Kennedy Joseph T General Counsel Apr 30, 2020 Option Exercise $8.26 1,902 15,711 198,827 May 01, 2020, 08:09 PM
THERO JOHN F President and CEO Apr 30, 2020 Option Exercise $8.26 5,302 43,795 2,496,781 May 01, 2020, 08:08 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Mar 31, 2020 Option Exercise $13.58 1,506 20,451 190,455 Apr 02, 2020, 08:14 PM
Kalb Michael Wayne SVP and CFO Mar 31, 2020 Option Exercise $13.58 1,498 20,343 85,485 Apr 02, 2020, 08:14 PM
Ketchum Steven B Chief Scientific Officer Mar 31, 2020 Option Exercise $13.58 1,506 20,451 517,562 Apr 02, 2020, 08:13 PM
THERO JOHN F President and CEO Mar 31, 2020 Option Exercise $13.58 5,302 72,001 2,488,611 Apr 02, 2020, 08:12 PM
THERO JOHN F President and CEO Mar 04, 2020 Sale $15.99 200,000 3,198,700 2,480,441 Mar 06, 2020, 08:03 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Feb 28, 2020 Option Exercise $14.67 1,506 22,093 188,905 Mar 03, 2020, 08:05 PM
Kalb Michael Wayne SVP and CFO Feb 28, 2020 Option Exercise $14.67 1,498 21,976 83,927 Mar 03, 2020, 08:04 PM
Ketchum Steven B Chief Scientific Officer Feb 28, 2020 Option Exercise $14.67 1,506 22,093 516,012 Mar 03, 2020, 08:04 PM
THERO JOHN F President and CEO Feb 28, 2020 Option Exercise $14.67 5,302 77,780 2,680,441 Mar 03, 2020, 08:02 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Feb 25, 2020 Option Exercise $17.58 25,586 449,802 187,355 Feb 27, 2020, 08:03 PM
Kalb Michael Wayne SVP and CFO Feb 25, 2020 Option Exercise $17.58 25,440 447,235 82,369 Feb 27, 2020, 08:03 PM
Ketchum Steven B Chief Scientific Officer Feb 25, 2020 Option Exercise $17.58 25,586 449,802 514,462 Feb 27, 2020, 08:03 PM
Kennedy Joseph T General Counsel Feb 25, 2020 Option Exercise $17.58 32,324 568,256 189,895 Feb 27, 2020, 08:03 PM
THERO JOHN F President and CEO Feb 25, 2020 Option Exercise $17.58 90,124 1,584,380 2,672,271 Feb 27, 2020, 08:02 PM
THERO JOHN F President and CEO Jan 31, 2020 Option Exercise $19.04 124,287 2,366,425 2,533,365 Feb 04, 2020, 08:02 PM
Kennedy Joseph T General Counsel Jan 31, 2020 Option Exercise $19.04 39,632 754,593 160,825 Feb 04, 2020, 08:02 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2020 Option Exercise $19.04 33,603 639,801 488,100 Feb 04, 2020, 08:02 PM
Kalb Michael Wayne SVP and CFO Jan 31, 2020 Option Exercise $19.04 33,425 636,412 55,861 Feb 04, 2020, 08:02 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jan 31, 2020 Option Exercise $19.04 14,547 276,975 160,993 Feb 04, 2020, 08:02 PM
Zakrzewski Joseph S Director Jan 03, 2020 Option Exercise $3.40 300,000 1,020,000 384,547 Jan 03, 2020, 09:30 PM
Zakrzewski Joseph S Director Jan 03, 2020 Sale $20.94 300,000 6,282,870 84,547 Jan 03, 2020, 09:30 PM
Zakrzewski Joseph S Director Dec 16, 2019 Option Exercise $9.00 100,000 900,000 184,547 Dec 18, 2019, 08:05 PM
Zakrzewski Joseph S Director Dec 16, 2019 Sale $25.83 100,000 2,583,380 84,547 Dec 18, 2019, 08:05 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Dec 16, 2019 Option Exercise $12.60 43,253 544,988 177,059 Dec 18, 2019, 08:05 PM
Kalb Michael Wayne SVP and CFO Dec 16, 2019 Option Exercise $2.19 25,000 54,750 46,552 Dec 18, 2019, 08:05 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Dec 16, 2019 Sale $25.46 43,253 1,101,364 133,806 Dec 18, 2019, 08:05 PM
Kalb Michael Wayne SVP and CFO Dec 16, 2019 Sale $23.36 25,000 584,012 30,152 Dec 18, 2019, 08:05 PM
THERO JOHN F President and CEO Nov 19, 2019 Sale $22.65 274,454 6,217,371 2,342,285 Nov 21, 2019, 08:49 PM
Ekman Lars Director Nov 12, 2019 Option Exercise $14.40 38,600 555,840 38,600 Nov 13, 2019, 08:05 PM
Ekman Lars Director Nov 12, 2019 Sale $19.35 38,600 746,759 0 Nov 13, 2019, 08:05 PM
THERO JOHN F President and CEO Nov 11, 2019 Sale $17.12 475,546 8,143,452 2,658,480 Nov 13, 2019, 08:01 PM
Ekman Lars Director Nov 05, 2019 Option Exercise $14.40 6,400 92,160 6,400 Nov 07, 2019, 08:05 PM
Ekman Lars Director Nov 05, 2019 Sale $18.00 6,400 115,230 0 Nov 07, 2019, 08:05 PM
THERO JOHN F President and CEO Oct 28, 2019 Option Exercise $2.50 11,601 29,003 3,092,285 Oct 30, 2019, 08:10 PM
THERO JOHN F President and CEO Oct 07, 2019 Option Exercise $14.37 497,876 7,154,478 3,080,684 Oct 09, 2019, 08:04 PM
Ketchum Steven B Chief Scientific Officer Oct 07, 2019 Option Exercise $14.37 100,023 1,437,330 453,969 Oct 09, 2019, 08:03 PM
Kennedy Joseph T General Counsel Oct 07, 2019 Option Exercise $14.37 105,037 1,509,382 125,723 Oct 09, 2019, 08:02 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Oct 07, 2019 Option Exercise $14.37 102,045 1,466,387 133,806 Oct 09, 2019, 08:01 PM
Ekman Lars Director Sep 03, 2019 Option Exercise $3.52 91,016 320,280 91,016 Sep 05, 2019, 08:04 PM
Ekman Lars Director Sep 03, 2019 Sale $15.01 91,016 1,365,722 0 Sep 05, 2019, 08:04 PM
THERO JOHN F President and CEO Aug 21, 2019 Option Exercise $2.50 24,999 62,498 2,313,310 Aug 23, 2019, 08:19 PM
THERO JOHN F President and CEO Aug 21, 2019 Option Exercise $1.56 191,997 300,010 2,324,911 Aug 22, 2019, 08:02 PM
STACK DAVID M Director Jul 11, 2019 Option Exercise $2.33 51,991 121,035 51,991 Jul 12, 2019, 08:03 PM
STACK DAVID M Director Jul 11, 2019 Sale $22.28 51,991 1,158,354 0 Jul 12, 2019, 08:03 PM
Zakrzewski Joseph S Director Jul 05, 2019 Option Exercise $9.00 100,000 900,000 184,547 Jul 05, 2019, 09:00 PM
Zakrzewski Joseph S Director Jul 05, 2019 Sale $23.82 100,000 2,381,580 84,547 Jul 05, 2019, 09:00 PM
Kennedy Joseph T General Counsel Jul 01, 2019 Option Exercise $2.57 27,244 69,962 85,446 Jul 03, 2019, 08:01 PM
Kennedy Joseph T General Counsel Jul 01, 2019 Sale $19.52 54,186 1,057,906 31,260 Jul 03, 2019, 08:01 PM
Kalb Michael Wayne SVP and CFO Jul 01, 2019 Option Exercise $2.19 50,000 109,500 70,840 Jul 03, 2019, 08:00 PM
Kalb Michael Wayne SVP and CFO Jul 01, 2019 Sale $19.67 50,000 983,270 20,840 Jul 03, 2019, 08:00 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 02, 2019 Option Exercise $2.50 69,564 173,910 105,915 Jul 03, 2019, 08:00 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 03, 2019 Option Exercise $2.80 29,250 81,900 65,601 Jul 03, 2019, 08:00 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 03, 2019 Sale $22.64 29,250 662,238 36,351 Jul 03, 2019, 08:00 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 02, 2019 Sale $20.73 69,564 1,442,141 55,915 Jul 03, 2019, 08:00 PM
Kennedy Joseph T General Counsel Jun 30, 2019 Option Exercise $19.39 26,495 513,738 58,202 Jul 02, 2019, 08:05 PM
THERO JOHN F President and CEO Jun 30, 2019 Option Exercise $19.39 14,757 286,138 2,132,914 Jul 02, 2019, 08:05 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jun 24, 2019 Option Exercise $2.50 100,000 250,000 149,546 Jun 26, 2019, 08:09 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jun 24, 2019 Sale $18.59 113,195 2,104,521 36,351 Jun 26, 2019, 08:09 PM
Zakrzewski Joseph S Director Jun 18, 2019 Option Exercise $3.40 100,000 340,000 184,547 Jun 20, 2019, 08:05 PM
Zakrzewski Joseph S Director Jun 18, 2019 Sale $19.02 100,000 1,902,090 84,547 Jun 20, 2019, 08:05 PM
Kennedy Joseph T General Counsel May 31, 2019 Option Exercise $2.57 27,229 69,925 58,489 May 31, 2019, 08:04 PM
Kennedy Joseph T General Counsel May 31, 2019 Sale $17.92 27,229 488,058 31,260 May 31, 2019, 08:04 PM
STACK DAVID M Director May 29, 2019 Option Exercise $3.21 33,799 108,495 33,799 May 31, 2019, 08:02 PM
STACK DAVID M Director May 29, 2019 Sale $18.45 33,799 623,534 0 May 31, 2019, 08:02 PM
STACK DAVID M Director May 17, 2019 Option Exercise $3.21 13,174 42,289 13,174 May 21, 2019, 08:14 PM
STACK DAVID M Director May 17, 2019 Sale $18.00 13,174 237,139 0 May 21, 2019, 08:14 PM
Ketchum Steven B Chief Scientific Officer Apr 30, 2019 Option Exercise $2.33 9,541 22,235 364,033 May 02, 2019, 09:05 PM
Ketchum Steven B Chief Scientific Officer Apr 30, 2019 Sale $18.67 9,541 178,107 354,492 May 02, 2019, 09:05 PM
Kennedy Joseph T General Counsel Apr 30, 2019 Option Exercise $2.57 27,230 69,927 58,490 May 02, 2019, 09:01 PM
Kennedy Joseph T General Counsel Apr 30, 2019 Sale $18.69 27,230 508,839 31,260 May 02, 2019, 09:01 PM
Berg Aaron CHIEF COMMERCIAL OFFICER May 01, 2019 Option Exercise $18.70 12,805 239,454 49,546 May 02, 2019, 08:02 PM
THERO JOHN F President and CEO Mar 31, 2019 Option Exercise $20.76 14,757 306,355 2,110,171 Apr 01, 2019, 08:24 PM
Ketchum Steven B Chief Scientific Officer Apr 01, 2019 Option Exercise $2.33 9,542 22,236 364,034 Apr 01, 2019, 08:22 PM
Ketchum Steven B Chief Scientific Officer Apr 01, 2019 Sale $20.06 9,542 191,392 354,592 Apr 01, 2019, 08:22 PM
Kennedy Joseph T General Counsel Mar 31, 2019 Option Exercise $20.76 26,495 550,036 58,202 Apr 01, 2019, 08:20 PM
Kennedy Joseph T General Counsel Apr 01, 2019 Option Exercise $2.57 27,230 69,926 85,432 Apr 01, 2019, 08:20 PM
Kennedy Joseph T General Counsel Apr 01, 2019 Sale $20.05 54,172 1,086,122 32,372 Apr 01, 2019, 08:20 PM
THERO JOHN F President and CEO Mar 04, 2019 Sale $21.31 250,000 5,327,234 2,158,101 Mar 06, 2019, 08:16 PM
Ekman Lars Director Mar 04, 2019 Option Exercise $2.04 135,377 276,743 135,377 Mar 06, 2019, 08:16 PM
Ekman Lars Director Mar 04, 2019 Sale $21.31 135,377 2,884,905 36,700 Mar 06, 2019, 08:16 PM
Ketchum Steven B Chief Scientific Officer Mar 01, 2019 Option Exercise $2.50 46,000 115,000 400,492 Mar 01, 2019, 08:19 PM
Ketchum Steven B Chief Scientific Officer Feb 28, 2019 Option Exercise $2.33 9,543 22,239 364,035 Mar 01, 2019, 08:19 PM
Ketchum Steven B Chief Scientific Officer Feb 28, 2019 Sale $20.67 9,543 197,249 354,492 Mar 01, 2019, 08:19 PM
Ketchum Steven B Chief Scientific Officer Mar 01, 2019 Sale $22.09 46,000 1,016,275 396,989 Mar 01, 2019, 08:19 PM
Kalb Michael Wayne SVP and CFO Mar 01, 2019 Option Exercise $2.83 100,000 283,350 120,551 Mar 01, 2019, 08:18 PM
Kalb Michael Wayne SVP and CFO Mar 01, 2019 Sale $22.09 100,000 2,209,098 113,427 Mar 01, 2019, 08:18 PM
Kennedy Joseph T General Counsel Feb 28, 2019 Option Exercise $2.57 27,231 69,928 58,491 Mar 01, 2019, 08:17 PM
Kennedy Joseph T General Counsel Feb 28, 2019 Sale $20.72 27,231 564,172 31,260 Mar 01, 2019, 08:17 PM
Zakrzewski Joseph S Director Feb 22, 2019 Option Exercise $8.70 180,625 1,572,312 265,172 Feb 22, 2019, 09:34 PM
Zakrzewski Joseph S Director Feb 22, 2019 Sale $19.90 180,625 3,594,437 84,547 Feb 22, 2019, 09:34 PM
VAN HEEK G JAN Director Feb 22, 2019 Option Exercise $4.46 192,347 857,170 217,550 Feb 22, 2019, 09:33 PM
VAN HEEK G JAN Director Feb 22, 2019 Sale $20.02 203,382 4,071,423 14,168 Feb 22, 2019, 09:33 PM
Peterson Kristine Director Feb 22, 2019 Option Exercise $5.80 163,500 947,730 163,500 Feb 22, 2019, 09:32 PM
Peterson Kristine Director Feb 22, 2019 Sale $20.02 163,500 3,274,038 0 Feb 22, 2019, 09:32 PM
Kalb Michael Wayne SVP and CFO Feb 22, 2019 Option Exercise $2.95 50,000 147,500 70,551 Feb 22, 2019, 09:31 PM
Kalb Michael Wayne SVP and CFO Feb 22, 2019 Sale $18.97 50,000 948,500 20,551 Feb 22, 2019, 09:31 PM
Kalb Michael Wayne SVP and CFO Feb 15, 2019 Sale $17.58 25,000 439,525 20,551 Feb 15, 2019, 08:16 PM
THERO JOHN F President and CEO Jan 31, 2019 Option Exercise $16.94 143,177 2,425,418 2,337,428 Feb 01, 2019, 08:35 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2019 Option Exercise $16.94 40,482 685,765 382,481 Feb 01, 2019, 08:35 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2019 Option Exercise $2.33 9,541 22,235 350,838 Feb 01, 2019, 08:35 PM
Ketchum Steven B Chief Scientific Officer Feb 01, 2019 Sale $17.06 27,989 477,498 354,492 Feb 01, 2019, 08:35 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2019 Sale $17.49 9,541 166,875 341,297 Feb 01, 2019, 08:35 PM
Kennedy Joseph T General Counsel Jan 31, 2019 Option Exercise $16.94 43,962 744,716 73,884 Feb 01, 2019, 08:34 PM
Kennedy Joseph T General Counsel Jan 31, 2019 Option Exercise $2.46 29,180 71,910 29,180 Feb 01, 2019, 08:34 PM
Kennedy Joseph T General Counsel Jan 31, 2019 Sale $17.49 42,624 745,468 31,260 Feb 01, 2019, 08:34 PM
Kalb Michael Wayne SVP and CFO Jan 31, 2019 Option Exercise $16.94 26,935 456,279 45,551 Feb 01, 2019, 08:33 PM
Kennedy Joseph T General Counsel Jan 23, 2019 Option Exercise $7.19 255,779 1,840,134 473,713 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 22, 2019 Option Exercise $4.59 175,300 804,656 393,234 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 24, 2019 Option Exercise $6.06 391,181 2,370,612 609,115 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 23, 2019 Sale $17.95 255,779 4,591,310 217,934 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 22, 2019 Sale $17.92 175,300 3,141,884 217,934 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 24, 2019 Sale $17.66 609,115 10,754,717 0 Jan 24, 2019, 08:20 PM
Zakrzewski Joseph S Director Jan 10, 2019 Option Exercise $3.40 200,000 680,000 284,547 Jan 11, 2019, 08:18 PM
Zakrzewski Joseph S Director Jan 10, 2019 Sale $16.98 200,000 3,396,390 184,547 Jan 11, 2019, 08:18 PM
STACK DAVID M Director Jan 10, 2019 Option Exercise $5.86 98,572 577,855 98,572 Jan 11, 2019, 08:18 PM
STACK DAVID M Director Jan 10, 2019 Option Exercise $2.94 26,932 79,172 26,932 Jan 11, 2019, 08:18 PM
STACK DAVID M Director Jan 10, 2019 Sale $18.00 98,572 1,774,296 0 Jan 11, 2019, 08:18 PM
STACK DAVID M Director Jan 10, 2019 Sale $18.00 26,932 484,776 0 Jan 11, 2019, 08:18 PM
Kennedy Joseph T General Counsel Jan 11, 2019 Option Exercise $2.95 3,173 9,360 221,107 Jan 11, 2019, 08:17 PM
Kennedy Joseph T General Counsel Jan 11, 2019 Sale $18.92 3,173 60,033 217,934 Jan 11, 2019, 08:17 PM
Kalb Michael Wayne SVP and CFO Jan 09, 2019 Option Exercise $2.19 200,000 438,000 217,486 Jan 11, 2019, 08:16 PM
Kalb Michael Wayne SVP and CFO Jan 09, 2019 Sale $15.26 200,000 3,051,080 17,486 Jan 11, 2019, 08:16 PM
Ekman Lars Director Jan 10, 2019 Option Exercise $1.03 100,416 103,428 140,416 Jan 11, 2019, 08:16 PM
Ekman Lars Director Jan 10, 2019 Sale $17.28 140,416 2,426,489 119,216 Jan 11, 2019, 08:16 PM
Zakrzewski Joseph S Director Jan 02, 2019 Option Exercise $3.21 385,000 1,237,250 469,547 Jan 02, 2019, 07:54 PM
Zakrzewski Joseph S Director Jan 02, 2019 Sale $13.03 385,000 5,015,703 84,547 Jan 02, 2019, 07:54 PM
Zakrzewski Joseph S Director Dec 28, 2018 Sale $13.19 141,500 1,866,668 84,547 Jan 02, 2019, 07:54 PM
Kennedy Joseph T General Counsel Dec 31, 2018 Option Exercise $13.24 26,495 350,794 244,877 Jan 02, 2019, 07:53 PM
Kennedy Joseph T General Counsel Dec 31, 2018 Sale $13.49 26,943 363,547 217,934 Jan 02, 2019, 07:53 PM
Ketchum Steven B Chief Scientific Officer Dec 31, 2018 Option Exercise $2.41 17,041 40,985 358,338 Jan 02, 2019, 07:51 PM
Ketchum Steven B Chief Scientific Officer Dec 31, 2018 Sale $13.51 17,041 230,212 341,297 Jan 02, 2019, 07:51 PM
THERO JOHN F President and CEO Dec 31, 2018 Option Exercise $13.24 14,757 195,383 2,117,271 Jan 02, 2019, 07:45 PM
Ketchum Steven B Chief Scientific Officer Nov 30, 2018 Option Exercise $2.41 17,042 40,988 358,339 Nov 30, 2018, 06:34 PM
Ketchum Steven B Chief Scientific Officer Nov 30, 2018 Sale $17.79 17,042 303,174 341,297 Nov 30, 2018, 06:34 PM
Kennedy Joseph T General Counsel Nov 30, 2018 Option Exercise $2.25 23,306 52,510 241,240 Nov 30, 2018, 06:33 PM
Kennedy Joseph T General Counsel Nov 30, 2018 Sale $17.81 23,306 414,998 217,934 Nov 30, 2018, 06:33 PM
THERO JOHN F President and CEO Nov 12, 2018 Option Exercise $1.35 407,611 550,275 2,702,139 Nov 14, 2018, 06:02 PM
THERO JOHN F President and CEO Nov 12, 2018 Sale $19.07 607,611 11,587,896 2,565,717 Nov 14, 2018, 06:02 PM
Ketchum Steven B Chief Scientific Officer Oct 31, 2018 Option Exercise $2.41 17,042 40,988 358,339 Nov 02, 2018, 06:11 PM
Ketchum Steven B Chief Scientific Officer Oct 31, 2018 Sale $20.74 17,042 353,454 341,797 Nov 02, 2018, 06:11 PM
Kennedy Joseph T General Counsel Oct 31, 2018 Option Exercise $2.25 23,307 52,513 241,241 Nov 02, 2018, 06:10 PM
Kennedy Joseph T General Counsel Oct 31, 2018 Sale $20.74 23,307 483,362 218,534 Nov 02, 2018, 06:10 PM
THERO JOHN F President and CEO Sep 30, 2018 Option Exercise $16.27 14,757 240,096 2,294,528 Oct 02, 2018, 07:11 PM
Ketchum Steven B Chief Scientific Officer Sep 28, 2018 Option Exercise $8.77 200,000 1,754,000 541,297 Oct 02, 2018, 07:05 PM
Ketchum Steven B Chief Scientific Officer Oct 01, 2018 Option Exercise $7.86 116,604 916,893 457,901 Oct 02, 2018, 07:05 PM
Ketchum Steven B Chief Scientific Officer Sep 28, 2018 Sale $15.50 200,000 3,100,000 441,297 Oct 02, 2018, 07:05 PM
Ketchum Steven B Chief Scientific Officer Oct 01, 2018 Sale $17.20 116,604 2,005,589 341,297 Oct 02, 2018, 07:05 PM
Kennedy Joseph T General Counsel Sep 30, 2018 Option Exercise $16.27 26,495 431,074 244,877 Oct 02, 2018, 07:02 PM
Kennedy Joseph T General Counsel Oct 01, 2018 Option Exercise $2.25 23,306 52,510 268,183 Oct 02, 2018, 07:02 PM
Kennedy Joseph T General Counsel Oct 01, 2018 Sale $16.81 50,249 844,528 235,134 Oct 02, 2018, 07:02 PM
Zakrzewski Joseph S Director Sep 24, 2018 Option Exercise $3.40 500,000 1,700,000 726,047 Sep 26, 2018, 08:54 PM
Zakrzewski Joseph S Director Sep 24, 2018 Sale $10.60 500,000 5,299,334 318,796 Sep 26, 2018, 08:54 PM
Ketchum Steven B Chief Scientific Officer Sep 25, 2018 Option Exercise $8.77 200,000 1,754,000 541,297 Sep 26, 2018, 08:52 PM
Ketchum Steven B Chief Scientific Officer Sep 24, 2018 Option Exercise $3.82 620,065 2,366,711 1,020,538 Sep 26, 2018, 08:52 PM
Ketchum Steven B Chief Scientific Officer Sep 25, 2018 Sale $13.50 200,000 2,700,000 441,297 Sep 26, 2018, 08:52 PM
Ketchum Steven B Chief Scientific Officer Sep 24, 2018 Sale $10.39 679,241 7,060,024 490,747 Sep 26, 2018, 08:52 PM
Kennedy Joseph T General Counsel Sep 24, 2018 Option Exercise $2.22 1,079,706 2,393,014 1,297,640 Sep 26, 2018, 08:50 PM
Kennedy Joseph T General Counsel Sep 24, 2018 Sale $10.56 1,079,706 11,400,975 412,840 Sep 26, 2018, 08:50 PM
Kalb Michael Wayne SVP and CFO Sep 24, 2018 Option Exercise $2.19 150,000 328,500 164,996 Sep 26, 2018, 08:47 PM
Kalb Michael Wayne SVP and CFO Sep 24, 2018 Sale $10.42 150,000 1,562,751 85,196 Sep 26, 2018, 08:47 PM
THERO JOHN F President and CEO Sep 22, 2018 Option Exercise $2.99 497,876 1,488,649 2,271,785 Sep 25, 2018, 06:35 PM
THERO JOHN F President and CEO Jun 30, 2018 Option Exercise $3.09 14,757 45,599 1,504,411 Jul 03, 2018, 12:00 AM
Kennedy Joseph T General Counsel Jun 30, 2018 Option Exercise $3.09 26,495 81,870 45,376 Jul 03, 2018, 12:00 AM
Kennedy Joseph T General Counsel Jul 02, 2018 Sale $3.00 26,942 80,955 18,434 Jul 03, 2018, 12:00 AM
THERO JOHN F President and CEO Mar 31, 2018 Option Exercise $3.01 14,757 44,419 1,481,668 Apr 03, 2018, 08:12 PM
Kennedy Joseph T General Counsel Mar 31, 2018 Option Exercise $3.01 26,495 79,750 45,376 Apr 03, 2018, 08:12 PM
Kennedy Joseph T General Counsel Apr 03, 2018 Sale $2.89 19,042 55,052 18,434 Apr 03, 2018, 08:12 PM
Kennedy Joseph T General Counsel Apr 02, 2018 Sale $2.91 7,900 23,020 37,476 Apr 03, 2018, 08:12 PM
THERO JOHN F President and CEO Jan 31, 2018 Option Exercise $3.83 197,513 756,475 1,458,925 Feb 02, 2018, 08:28 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2018 Option Exercise $3.83 57,428 219,949 200,973 Feb 02, 2018, 08:26 PM
Kennedy Joseph T General Counsel Jan 31, 2018 Option Exercise $3.83 60,313 230,999 63,291 Feb 02, 2018, 08:25 PM
Kennedy Joseph T General Counsel Jan 31, 2018 Sale $3.73 44,857 167,388 18,434 Feb 02, 2018, 08:25 PM
Kalb Michael Wayne SVP and CFO Jan 31, 2018 Option Exercise $3.83 14,004 53,635 14,996 Feb 02, 2018, 08:24 PM
Ketchum Steven B Chief Scientific Officer Jan 23, 2018 Option Exercise $2.04 135,205 275,818 277,002 Jan 23, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 23, 2018 Sale $4.41 135,205 596,430 141,797 Jan 23, 2018, 06:00 PM
Kennedy Joseph T General Counsel Jan 12, 2018 Sale $4.29 9,587 41,128 41,519 Jan 17, 2018, 05:58 PM
Kennedy Joseph T General Counsel Jan 17, 2018 Sale $4.03 31,519 127,022 0 Jan 17, 2018, 05:58 PM
Kennedy Joseph T General Counsel Jan 16, 2018 Sale $4.13 10,000 41,300 31,519 Jan 17, 2018, 05:58 PM
Ketchum Steven B Chief Scientific Officer Jan 11, 2018 Option Exercise $2.04 2,612 5,328 144,409 Jan 16, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 11, 2018 Sale $4.40 2,612 11,493 141,797 Jan 16, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 05, 2018 Option Exercise $2.04 64,683 131,953 206,480 Jan 09, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 05, 2018 Sale $4.40 64,683 284,631 141,797 Jan 09, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 02, 2018 Option Exercise $1.20 128,257 153,583 270,054 Jan 04, 2018, 07:40 PM
Ketchum Steven B Chief Scientific Officer Jan 02, 2018 Sale $4.25 128,257 545,092 141,797 Jan 04, 2018, 07:40 PM
THERO JOHN F President and CEO Dec 31, 2017 Option Exercise $4.01 15,732 63,085 1,156,771 Jan 02, 2018, 04:32 PM
Kennedy Joseph T General Counsel Dec 31, 2017 Option Exercise $4.01 27,885 111,819 51,106 Jan 02, 2018, 04:32 PM
THERO JOHN F President and CEO Nov 30, 2017 Buy $3.24 10,000 32,446 1,135,003 Dec 04, 2017, 09:02 AM
Ketchum Steven B Chief Scientific Officer Oct 05, 2017 Sale $3.48 63,479 221,199 141,797 Oct 06, 2017, 07:22 PM
THERO JOHN F President and CEO Sep 30, 2017 Option Exercise $3.50 15,732 55,062 1,125,003 Oct 03, 2017, 04:24 PM
Kennedy Joseph T General Counsel Sep 30, 2017 Option Exercise $3.50 27,885 97,598 25,553 Oct 03, 2017, 04:24 PM
THERO JOHN F President and CEO Jun 30, 2017 Option Exercise $4.03 15,732 63,400 1,103,235 Jul 03, 2017, 07:21 PM
Kennedy Joseph T General Counsel Jun 30, 2017 Option Exercise $4.03 27,885 112,377 156,143 Jul 03, 2017, 07:20 PM
Kennedy Joseph T General Counsel Jun 29, 2017 Sale $3.98 151,768 603,824 130,591 Jul 03, 2017, 07:20 PM
Kennedy Joseph T General Counsel Jul 03, 2017 Sale $4.09 51,104 209,158 0 Jul 03, 2017, 07:20 PM
Kennedy Joseph T General Counsel Jun 30, 2017 Sale $3.98 105,039 417,950 51,104 Jul 03, 2017, 07:20 PM
Kennedy Joseph T General Counsel Mar 31, 2017 Option Exercise $3.20 26,981 86,339 282,359 Apr 03, 2017, 05:01 PM
THERO JOHN F President and CEO Mar 31, 2017 Option Exercise $3.20 15,732 50,342 1,081,467 Apr 03, 2017, 05:00 PM
THERO JOHN F President and CEO Jan 31, 2017 Option Exercise $2.97 231,718 688,202 1,059,699 Feb 02, 2017, 05:07 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2017 Option Exercise $2.97 70,236 208,601 205,276 Feb 02, 2017, 05:06 PM
Kennedy Joseph T General Counsel Jan 31, 2017 Option Exercise $2.97 75,875 225,349 255,903 Feb 02, 2017, 05:04 PM
Kennedy Joseph T General Counsel Dec 31, 2016 Option Exercise $3.08 27,885 85,886 187,673 Jan 03, 2017, 04:31 PM
THERO JOHN F President and CEO Dec 31, 2016 Option Exercise $3.08 20,194 62,198 741,917 Jan 03, 2017, 04:30 PM
Kennedy Joseph T General Counsel Nov 09, 2016 Sale $3.04 122,358 372,042 162,120 Nov 10, 2016, 05:00 PM
Kennedy Joseph T General Counsel Sep 30, 2016 Option Exercise $3.19 27,885 88,953 284,478 Sep 30, 2016, 09:26 PM
THERO JOHN F President and CEO Sep 30, 2016 Option Exercise $3.19 20,194 64,419 724,611 Sep 30, 2016, 09:25 PM
THERO JOHN F President and CEO Jun 30, 2016 Option Exercise $2.16 14,719 31,793 707,305 Jul 05, 2016, 07:09 PM
Kennedy Joseph T General Counsel Jun 30, 2016 Option Exercise $2.16 27,885 60,232 258,925 Jul 05, 2016, 07:08 PM
Kennedy Joseph T General Counsel Mar 31, 2016 Option Exercise $1.53 20,082 30,725 233,373 Apr 01, 2016, 06:00 PM
THERO JOHN F President and CEO Mar 31, 2016 Option Exercise $1.53 14,719 22,520 684,524 Apr 01, 2016, 05:58 PM
THERO JOHN F President and CEO Feb 01, 2016 Buy $1.37 25,000 34,250 661,743 Feb 03, 2016, 08:11 AM
THERO JOHN F President and CEO Jan 31, 2016 Option Exercise $1.36 172,157 234,134 636,743 Feb 02, 2016, 04:18 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2016 Option Exercise $1.36 42,531 57,842 131,407 Feb 02, 2016, 04:17 PM
Kennedy Joseph T General Counsel Jan 31, 2016 Option Exercise $1.36 47,581 64,710 200,018 Feb 02, 2016, 04:15 PM
Farrell Michael James VP, Finance Jan 31, 2016 Option Exercise $1.36 11,597 15,772 30,190 Feb 02, 2016, 04:14 PM
Kennedy Joseph T General Counsel Dec 31, 2015 Option Exercise $1.89 20,082 37,955 130,161 Jan 04, 2016, 05:14 PM
Kennedy Joseph T General Counsel Oct 05, 2015 Option Exercise $2.05 2,349 4,815 96,805 Oct 06, 2015, 04:31 PM
Kennedy Joseph T General Counsel Sep 30, 2015 Option Exercise $1.93 17,734 34,227 92,904 Oct 02, 2015, 04:31 PM
THERO JOHN F President and CEO Aug 11, 2015 Buy $2.35 20,000 47,000 304,400 Aug 11, 2015, 04:30 PM
Farrell Michael James Controller Nov 11, 2014 Buy $0.84 5,500 4,606 6,037 Nov 12, 2014, 07:59 PM
THERO JOHN F President, Chief Exec. Officer Nov 12, 2014 Buy $0.88 20,000 17,600 114,900 Nov 12, 2014, 07:59 PM
THERO JOHN F President, Chief Exec. Officer Nov 11, 2014 Buy $0.80 30,000 24,000 94,900 Nov 12, 2014, 07:59 PM
Ekman Lars Director Nov 20, 2013 Buy $1.80 40,000 72,000 40,000 Nov 20, 2013, 06:11 PM
THERO JOHN F President Nov 20, 2013 Buy $1.90 5,000 9,500 64,900 Nov 20, 2013, 04:18 PM
Zakrzewski Joseph S Chief Executive Officer Nov 18, 2013 Buy $1.54 50,777 78,197 226,047 Nov 18, 2013, 04:15 PM
VAN HEEK G JAN Director Jul 10, 2013 Option Exercise $5.59 1,755 9,810 25,203 Jul 11, 2013, 06:59 AM
Zakrzewski Joseph S Chief Executive Officer Jun 25, 2013 Option Exercise $1.35 10,000 13,500 141,937 Jun 25, 2013, 04:05 PM
Zakrzewski Joseph S Chief Executive Officer Jun 21, 2013 Option Exercise $1.35 10,000 13,500 131,937 Jun 21, 2013, 04:05 PM
THERO JOHN F President May 29, 2013 Option Exercise $1.35 11,000 14,850 50,450 May 29, 2013, 04:30 PM
Zakrzewski Joseph S Chief Executive Officer Apr 25, 2013 Option Exercise $1.35 10,000 13,500 121,937 Apr 25, 2013, 04:23 PM
VAN HEEK G JAN Director Apr 10, 2013 Option Exercise $7.38 1,329 9,808 23,448 Apr 15, 2013, 08:44 AM
THERO JOHN F President Jan 30, 2013 Option Exercise $1.35 10,000 13,500 39,450 Jan 30, 2013, 05:58 PM
VAN HEEK G JAN Director Jan 10, 2013 Option Exercise $8.37 948 7,935 22,119 Jan 14, 2013, 07:08 AM
VAN HEEK G JAN Director Oct 10, 2012 Option Exercise $11.20 708 7,930 21,171 Oct 12, 2012, 08:32 AM
Zakrzewski Joseph S Chief Executive Officer Oct 01, 2012 Option Exercise $1.35 150,000 202,500 261,937 Oct 03, 2012, 09:50 PM
Zakrzewski Joseph S Chief Executive Officer Oct 01, 2012 Sale $12.56 150,000 1,884,315 111,937 Oct 03, 2012, 09:50 PM
THERO JOHN F President Sep 24, 2012 Option Exercise $1.35 10,000 13,500 29,450 Sep 24, 2012, 04:35 PM
THERO JOHN F President Sep 11, 2012 Option Exercise $1.35 10,000 13,500 19,450 Sep 11, 2012, 06:13 PM
HEALY JAMES Director Aug 31, 2012 Option Exercise $1.03 30,000 30,900 90,000 Sep 05, 2012, 06:33 PM
GORDON CARL L Director Sep 04, 2012 Sale $14.43 233,700 3,372,992 594,300 Sep 05, 2012, 05:38 PM
ORBIMED ADVISORS LLC Director Sep 04, 2012 Sale $14.43 233,700 3,372,992 594,300 Sep 05, 2012, 05:33 PM
HEALY JAMES Director Aug 14, 2012 Option Exercise $1.50 808,200 1,212,300 6,321,588 Aug 15, 2012, 07:28 PM
GORDON CARL L Director Jul 27, 2012 Sale $14.61 366,300 5,350,691 825,756 Jul 30, 2012, 07:32 PM
ORBIMED ADVISORS LLC Director Jul 27, 2012 Sale $14.61 3,456 50,483 7,944 Jul 30, 2012, 07:26 PM
ORBIMED ADVISORS LLC Director Jul 27, 2012 Sale $14.61 362,844 5,300,207 825,756 Jul 30, 2012, 07:26 PM
Zakrzewski Joseph S Chief Executive Officer Jul 27, 2012 Option Exercise $1.35 150,000 202,500 261,937 Jul 30, 2012, 06:51 PM
Zakrzewski Joseph S Chief Executive Officer Jul 27, 2012 Sale $14.31 150,000 2,147,192 189,991 Jul 30, 2012, 06:51 PM
THERO JOHN F President Jul 27, 2012 Option Exercise $2.37 300,926 713,750 160,376 Jul 30, 2012, 06:50 PM
THERO JOHN F President Jul 27, 2012 Sale $14.34 300,926 4,315,862 9,450 Jul 30, 2012, 06:50 PM
Kennedy Joseph T Senior VP and General Counsel Jul 27, 2012 Sale $13.85 6,950 96,290 6,409 Jul 30, 2012, 06:49 PM
Huff Paul Chief Commercial Officer Jul 27, 2012 Sale $13.85 6,950 96,290 6,409 Jul 30, 2012, 06:48 PM
SEDLACK STUART D Senior Vice President Jul 27, 2012 Sale $13.85 6,950 96,290 6,409 Jul 30, 2012, 06:46 PM
VAN HEEK G JAN Director Jul 10, 2012 Option Exercise $14.40 551 7,934 20,463 Jul 12, 2012, 06:36 PM
Huff Paul Chief Commercial Officer Jun 26, 2012 Option Exercise $8.79 1,100 9,669 1,100 Jun 27, 2012, 05:30 PM
Huff Paul Chief Commercial Officer Jun 27, 2012 Option Exercise $8.79 48,900 429,831 48,900 Jun 27, 2012, 05:30 PM
Huff Paul Chief Commercial Officer Jun 26, 2012 Sale $13.52 1,100 14,870 0 Jun 27, 2012, 05:30 PM
Huff Paul Chief Commercial Officer Jun 27, 2012 Sale $15.01 48,900 734,204 0 Jun 27, 2012, 05:30 PM
GORDON CARL L Director Jun 19, 2012 Sale $12.94 617,100 7,986,701 1,188,600 Jun 19, 2012, 07:37 PM
ORBIMED ADVISORS LLC Director Jun 19, 2012 Sale $12.91 5,900 76,185 11,400 Jun 19, 2012, 07:31 PM
ORBIMED ADVISORS LLC Director Jun 19, 2012 Sale $12.91 611,200 7,892,242 1,188,600 Jun 19, 2012, 07:31 PM
Huff Paul Chief Commercial Officer Jun 18, 2012 Option Exercise $8.79 162,925 1,432,111 162,925 Jun 19, 2012, 07:03 PM
Huff Paul Chief Commercial Officer Jun 15, 2012 Option Exercise $8.79 100 879 100 Jun 19, 2012, 07:03 PM
Huff Paul Chief Commercial Officer Jun 15, 2012 Sale $12.00 100 1,200 0 Jun 19, 2012, 07:03 PM
Huff Paul Chief Commercial Officer Jun 18, 2012 Sale $12.00 162,925 1,955,524 0 Jun 19, 2012, 07:03 PM
Huff Paul Chief Commercial Officer Jun 07, 2012 Option Exercise $6.64 16,725 111,008 16,725 Jun 08, 2012, 05:08 PM
Huff Paul Chief Commercial Officer Jun 07, 2012 Sale $12.06 16,725 201,635 0 Jun 08, 2012, 05:08 PM
Zakrzewski Joseph S Chief Executive Officer May 29, 2012 Option Exercise $1.35 150,000 202,500 228,604 May 31, 2012, 07:46 PM
Zakrzewski Joseph S Chief Executive Officer May 29, 2012 Sale $11.97 150,000 1,795,215 78,604 May 31, 2012, 07:46 PM
Abingworth LLP 10% Owner Apr 19, 2012 Sale $9.66 682,000 6,586,347 1,599,168 Apr 26, 2012, 05:04 PM
Abingworth LLP 10% Owner Apr 18, 2012 Sale $9.60 1,614,341 15,505,584 2,281,168 Apr 26, 2012, 05:04 PM
Abingworth LLP 10% Owner Apr 17, 2012 Sale $9.61 1,712,000 16,454,204 3,895,509 Apr 26, 2012, 05:04 PM
Abingworth LLP 10% Owner Apr 18, 2012 Sale $9.60 1,614,341 15,505,584 2,281,168 Apr 19, 2012, 05:58 PM
Abingworth LLP 10% Owner Apr 17, 2012 Sale $9.61 1,712,000 16,454,204 3,895,509 Apr 19, 2012, 05:58 PM
Abingworth LLP 10% Owner Apr 19, 2012 Sale $9.66 682,000 6,586,347 1,599,168 Apr 19, 2012, 05:58 PM
VAN HEEK G JAN Director Apr 10, 2012 Option Exercise $9.35 848 7,929 19,912 Apr 12, 2012, 07:46 PM
THERO JOHN F President Apr 09, 2012 Option Exercise $1.35 150,926 203,750 150,926 Apr 11, 2012, 05:57 PM
THERO JOHN F President Apr 09, 2012 Sale $9.96 150,926 1,503,072 0 Apr 11, 2012, 05:57 PM
Abingworth LLP 10% Owner Apr 03, 2012 Sale $11.00 2,300,000 25,300,000 5,607,509 Apr 05, 2012, 05:15 PM
HEALY JAMES Director Apr 03, 2012 Sale $10.98 1,735,650 19,059,665 6,513,388 Apr 04, 2012, 05:00 PM
HEALY JAMES Director Apr 02, 2012 Sale $10.99 264,350 2,905,286 7,249,038 Apr 04, 2012, 05:00 PM
HEALY JAMES Director Mar 29, 2012 Sale $10.98 993,698 10,910,804 7,513,388 Mar 30, 2012, 04:15 PM
HEALY JAMES Director Mar 28, 2012 Sale $11.73 6,302 73,922 8,507,086 Mar 30, 2012, 04:15 PM
Zakrzewski Joseph S Chief Executive Officer Mar 23, 2012 Option Exercise $1.35 160,000 216,000 238,604 Mar 27, 2012, 07:01 PM
Zakrzewski Joseph S Chief Executive Officer Mar 23, 2012 Sale $11.59 160,000 1,854,560 78,604 Mar 27, 2012, 07:01 PM
HEALY JAMES Director Jan 27, 2012 Option Exercise $1.03 60,000 61,800 60,000 Jan 31, 2012, 05:51 PM
VAN HEEK G JAN Director Jan 10, 2012 Option Exercise $7.06 894 6,312 19,064 Jan 12, 2012, 06:07 PM
Zakrzewski Joseph S Chief Executive Officer Nov 07, 2011 Option Exercise $1.35 5,000 6,750 78,604 Nov 07, 2011, 04:50 PM
VAN HEEK G JAN Director Oct 11, 2011 Option Exercise $9.47 666 6,307 18,170 Oct 18, 2011, 06:34 PM
Anderson Joseph Director Oct 11, 2011 Option Exercise $9.47 832 7,879 11,683 Oct 18, 2011, 06:32 PM
Zakrzewski Joseph S Chief Executive Officer Aug 22, 2011 Option Exercise $1.35 5,000 6,750 73,604 Aug 22, 2011, 05:01 PM
Zakrzewski Joseph S Chief Executive Officer Jul 15, 2011 Option Exercise $1.35 5,000 6,750 68,604 Jul 15, 2011, 07:07 PM
Zakrzewski Joseph S Chief Executive Officer Jul 15, 2011 Option Exercise $1.35 5,000 6,750 68,604 Jul 15, 2011, 05:57 PM
VAN HEEK G JAN Director Jul 11, 2011 Option Exercise $14.18 445 6,310 17,504 Jul 13, 2011, 05:27 PM
Anderson Joseph Director Jul 11, 2011 Option Exercise $14.18 468 6,636 10,851 Jul 13, 2011, 05:25 PM
Anderson Joseph Director Oct 11, 2010 Option Exercise $2.95 2,165 6,387 8,908 May 16, 2011, 09:46 PM
Anderson Joseph Director Jul 12, 2010 Option Exercise $2.28 2,801 6,386 6,743 May 16, 2011, 09:46 PM
Anderson Joseph Director Apr 12, 2010 Option Exercise $1.62 3,942 6,386 3,942 May 16, 2011, 09:46 PM
Anderson Joseph Director Apr 11, 2011 Option Exercise $8.50 751 6,384 10,383 May 16, 2011, 09:46 PM
Anderson Joseph Director Jan 10, 2011 Option Exercise $8.81 724 6,378 9,632 May 16, 2011, 09:46 PM
VAN HEEK G JAN Director Apr 11, 2011 Option Exercise $8.50 742 6,307 17,059 May 16, 2011, 09:25 PM
ORBIMED ADVISORS LLC Director May 02, 2011 Sale $16.30 300 4,890 17,300 May 03, 2011, 07:26 PM
ORBIMED ADVISORS LLC Director May 02, 2011 Sale $16.30 32,600 531,380 1,799,800 May 03, 2011, 07:26 PM
ORBIMED ADVISORS LLC Director Apr 29, 2011 Sale $16.01 1,000 16,010 17,600 May 03, 2011, 07:26 PM
ORBIMED ADVISORS LLC Director Apr 29, 2011 Sale $16.01 99,000 1,584,990 1,832,400 May 03, 2011, 07:26 PM
GORDON CARL L Director Apr 29, 2011 Sale $16.01 100,000 1,601,000 1,832,400 May 03, 2011, 07:20 PM
GORDON CARL L Director May 02, 2011 Sale $16.30 32,900 536,270 1,799,800 May 03, 2011, 07:20 PM
VAN HEEK G JAN Director Apr 25, 2011 Option Exercise $1.03 30,000 30,900 46,317 Apr 27, 2011, 06:44 PM
VAN HEEK G JAN Director Apr 25, 2011 Sale $16.58 30,000 497,379 16,317 Apr 27, 2011, 06:44 PM
VAN HEEK G JAN Director Apr 18, 2011 Sale $1.03 3,000 3,090 16,317 Apr 27, 2011, 06:37 PM
ORBIMED ADVISORS LLC Director Apr 20, 2011 Sale $15.79 7,600 120,004 25,700 Apr 26, 2011, 08:21 PM
ORBIMED ADVISORS LLC Director Apr 20, 2011 Sale $15.79 792,400 12,511,996 2,674,300 Apr 26, 2011, 08:21 PM
GORDON CARL L Director Apr 20, 2011 Sale $15.79 7,600 120,004 25,700 Apr 26, 2011, 08:16 PM
GORDON CARL L Director Apr 20, 2011 Sale $15.79 792,400 12,511,996 2,674,300 Apr 26, 2011, 08:16 PM
GORDON CARL L Director Apr 21, 2011 Sale $16.67 750,000 12,500,000 2,426,667 Apr 25, 2011, 09:51 PM
ORBIMED ADVISORS LLC Director Apr 21, 2011 Sale $16.67 7,100 118,333 23,333 Apr 25, 2011, 09:46 PM
ORBIMED ADVISORS LLC Director Apr 21, 2011 Sale $16.67 742,900 12,381,667 2,426,667 Apr 25, 2011, 09:46 PM
GORDON CARL L Director Apr 20, 2011 Sale $15.79 800,000 12,632,000 2,674,300 Apr 20, 2011, 09:43 PM
GORDON CARL L Director Apr 18, 2011 Sale $15.18 3,000,000 45,549,897 4,682,029 Apr 20, 2011, 09:43 PM
ORBIMED ADVISORS LLC Director Apr 20, 2011 Sale $15.79 800,000 12,632,000 2,674,300 Apr 20, 2011, 09:39 PM
ORBIMED ADVISORS LLC Director Apr 18, 2011 Sale $15.18 28,200 428,168 44,832 Apr 20, 2011, 09:39 PM
ORBIMED ADVISORS LLC Director Apr 18, 2011 Sale $15.18 2,971,800 45,121,729 4,682,029 Apr 20, 2011, 09:39 PM
Zakrzewski Joseph S Chief Executive Officer Apr 18, 2011 Option Exercise $2.72 300,000 815,000 363,604 Apr 20, 2011, 07:49 PM
Zakrzewski Joseph S Chief Executive Officer Apr 18, 2011 Sale $15.76 300,000 4,728,210 63,604 Apr 20, 2011, 07:49 PM
VAN HEEK G JAN Director Apr 18, 2011 Option Exercise $1.03 3,000 3,090 22,317 Apr 20, 2011, 07:41 PM
VAN HEEK G JAN Director Apr 18, 2011 Sale $16.51 3,000 49,530 19,317 Apr 20, 2011, 07:41 PM
Soni Paresh SVP and Head of Development Apr 19, 2011 Option Exercise $1.35 80,000 108,000 80,000 Apr 20, 2011, 07:39 PM
Soni Paresh SVP and Head of Development Apr 19, 2011 Sale $15.11 80,000 1,208,624 0 Apr 20, 2011, 07:39 PM
Ahlholm Frederick W Vice President Finance Apr 20, 2011 Option Exercise $1.70 31,250 53,125 31,250 Apr 20, 2011, 07:38 PM
Ahlholm Frederick W Vice President Finance Apr 20, 2011 Sale $15.88 31,250 496,344 0 Apr 20, 2011, 07:38 PM
Abingworth LLP 10% Owner Apr 18, 2011 Sale $14.87 4,179,174 62,143,480 7,895,826 Apr 20, 2011, 04:33 PM
Ahlholm Frederick W Vice President Finance Apr 04, 2011 Option Exercise $1.70 31,250 53,125 31,250 Apr 06, 2011, 05:42 PM
Ahlholm Frederick W Vice President Finance Apr 04, 2011 Sale $7.48 31,250 233,688 0 Apr 06, 2011, 05:42 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 29, 2011 Sale $7.25 424,900 3,080,610 8,513,388 Mar 31, 2011, 03:16 PM
GORDON CARL L Director Mar 28, 2011 Sale $7.35 93,100 684,285 6,438,500 Mar 28, 2011, 09:45 PM
GORDON CARL L Director Mar 25, 2011 Sale $7.47 56,900 425,043 6,530,700 Mar 28, 2011, 09:45 PM
GORDON CARL L Director Mar 24, 2011 Sale $7.50 23,000 172,500 6,587,100 Mar 28, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 28, 2011 Sale $7.35 92,200 677,670 6,438,500 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 25, 2011 Sale $7.47 500 3,735 62,400 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 25, 2011 Sale $7.47 56,400 421,308 6,530,700 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 24, 2011 Sale $7.50 200 1,500 62,900 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 24, 2011 Sale $7.50 22,800 171,000 6,587,100 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 28, 2011 Sale $7.35 900 6,615 61,500 Mar 28, 2011, 09:41 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 24, 2011 Sale $7.56 500,000 3,778,000 9,013,388 Mar 28, 2011, 08:37 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 25, 2011 Sale $7.50 75,100 563,333 8,938,288 Mar 28, 2011, 08:37 PM
GORDON CARL L Director Mar 21, 2011 Sale $7.05 77,000 542,850 6,609,900 Mar 23, 2011, 06:31 PM
ORBIMED ADVISORS LLC Director Mar 21, 2011 Sale $7.05 700 4,935 63,100 Mar 23, 2011, 06:27 PM
ORBIMED ADVISORS LLC Director Mar 21, 2011 Sale $7.05 76,300 537,915 6,609,900 Mar 23, 2011, 06:27 PM
GORDON CARL L Director Mar 14, 2011 Sale $7.33 75,000 549,750 6,735,700 Mar 15, 2011, 09:34 PM
GORDON CARL L Director Mar 11, 2011 Sale $7.43 100,000 743,000 6,810,000 Mar 15, 2011, 09:34 PM
GORDON CARL L Director Mar 15, 2011 Sale $7.24 50,000 362,000 6,686,200 Mar 15, 2011, 09:34 PM
ORBIMED ADVISORS LLC Director Mar 14, 2011 Sale $7.33 74,300 544,619 6,735,700 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 11, 2011 Sale $7.43 900 6,687 65,000 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 11, 2011 Sale $7.43 99,100 736,313 6,810,000 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 15, 2011 Sale $7.24 500 3,620 63,800 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 15, 2011 Sale $7.24 49,500 358,380 6,686,200 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 14, 2011 Sale $7.33 700 5,131 64,300 Mar 15, 2011, 09:29 PM
Abingworth LLP 10% Owner Mar 11, 2011 Sale $7.50 2,750,000 20,636,001 12,075,000 Mar 15, 2011, 02:16 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 11, 2011 Sale $7.50 2,000,000 15,000,000 9,513,388 Mar 14, 2011, 06:35 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 10, 2011 Sale $7.26 606,300 4,400,283 11,513,388 Mar 11, 2011, 09:27 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 09, 2011 Sale $7.25 30,700 222,575 12,119,688 Mar 11, 2011, 09:27 PM
Abingworth LLP 10% Owner Mar 08, 2011 Sale $7.50 550,000 4,125,990 14,825,000 Mar 10, 2011, 04:22 PM
Zakrzewski Joseph S Chief Executive Officer Mar 09, 2011 Option Exercise $1.35 10,000 13,500 63,604 Mar 09, 2011, 06:22 PM
Abingworth LLP 10% Owner Mar 04, 2011 Sale $7.60 100,000 760,000 15,375,000 Mar 08, 2011, 05:15 PM
GORDON CARL L Director Mar 03, 2011 Sale $7.76 7,000 54,320 6,976,500 Mar 07, 2011, 09:51 PM
GORDON CARL L Director Mar 07, 2011 Sale $7.68 25,000 192,000 6,909,100 Mar 07, 2011, 09:51 PM
GORDON CARL L Director Mar 04, 2011 Sale $7.62 43,000 327,660 6,933,900 Mar 07, 2011, 09:51 PM
ORBIMED ADVISORS LLC Director Mar 03, 2011 Sale $7.76 100 776 66,500 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 03, 2011 Sale $7.76 6,900 53,544 6,976,500 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 07, 2011 Sale $7.68 200 1,536 65,900 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 07, 2011 Sale $7.68 24,800 190,464 6,909,100 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 04, 2011 Sale $7.62 400 3,048 66,100 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 04, 2011 Sale $7.62 42,600 324,612 6,933,900 Mar 07, 2011, 09:45 PM
Abingworth LLP 10% Owner Mar 02, 2011 Sale $7.70 1,200,000 9,239,040 15,475,000 Mar 04, 2011, 01:31 PM
ORBIMED ADVISORS LLC Director Mar 01, 2011 Sale $7.56 49,500 374,220 7,077,500 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Feb 28, 2011 Sale $7.73 900 6,957 68,000 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Feb 28, 2011 Sale $7.73 99,100 766,043 7,127,000 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Mar 02, 2011 Sale $7.72 900 6,948 66,600 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Mar 02, 2011 Sale $7.72 94,100 726,452 6,983,400 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Mar 01, 2011 Sale $7.56 500 3,780 67,500 Mar 02, 2011, 08:40 PM
GORDON CARL L Director Feb 28, 2011 Sale $7.73 100,000 773,000 7,127,000 Mar 02, 2011, 08:33 PM
GORDON CARL L Director Mar 02, 2011 Sale $7.72 95,000 733,400 6,983,400 Mar 02, 2011, 08:33 PM
GORDON CARL L Director Mar 01, 2011 Sale $7.56 50,000 378,000 7,077,500 Mar 02, 2011, 08:33 PM
Abingworth LLP 10% Owner Mar 01, 2011 Sale $7.61 50,000 380,485 16,675,000 Mar 02, 2011, 01:57 PM
Abingworth LLP 10% Owner Feb 28, 2011 Sale $7.92 275,000 2,178,137 16,725,000 Mar 02, 2011, 01:57 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Feb 25, 2011 Sale $8.13 363,000 2,952,787 12,150,388 Mar 01, 2011, 05:24 PM
Zakrzewski Joseph S Chief Executive Officer Feb 25, 2011 Option Exercise $1.35 60,000 81,000 103,604 Feb 28, 2011, 07:08 PM
Zakrzewski Joseph S Chief Executive Officer Feb 25, 2011 Sale $8.16 60,000 489,755 53,604 Feb 28, 2011, 07:08 PM
Zakrzewski Joseph S Chief Executive Officer Feb 22, 2011 Option Exercise $1.35 100,000 135,000 153,604 Feb 24, 2011, 06:05 PM
Zakrzewski Joseph S Chief Executive Officer Feb 22, 2011 Sale $8.54 100,000 854,060 53,604 Feb 24, 2011, 06:05 PM
Soni Paresh SVP and Head of Development Feb 22, 2011 Option Exercise $1.35 120,000 162,000 120,000 Feb 24, 2011, 06:01 PM
Soni Paresh SVP and Head of Development Feb 22, 2011 Sale $8.49 120,000 1,018,764 0 Feb 24, 2011, 06:01 PM
Load More Insider Transactions
Buy Sale Option Exercise
Owner Relationship Date Value($)
Mikhail Karim President and CEO 04/12/2022 69,114
Kalb Michael Wayne SVP and CFO 02/28/2022 20,317
Ketchum Steven B Chief Scientific Officer 02/28/2022 18,011
Kalb Michael Wayne SVP and CFO 01/31/2022 17,865
Ketchum Steven B Chief Scientific Officer 01/31/2022 17,207
Kalb Michael Wayne SVP and CFO 12/31/2021 85,020
Mikhail Karim President and CEO 12/31/2021 12,985
Zakrzewski Joseph S Director 12/14/2021 32,689
Zakrzewski Joseph S Director 12/15/2021 6,310
Berg Aaron EVP, President US 08/31/2021 16,681
Kalb Michael Wayne SVP and CFO 08/31/2021 16,681
Ketchum Steven B Chief Scientific Officer 08/31/2021 17,324
Kalb Michael Wayne SVP and CFO 08/12/2021 281,800
Kalb Michael Wayne SVP and CFO 08/12/2021 630,240
Berg Aaron CHIEF COMMERCIAL OFFICER 07/30/2021 12,466
Kalb Michael Wayne SVP and CFO 07/30/2021 12,466
Ketchum Steven B Chief Scientific Officer 07/30/2021 12,946
Kennedy Joseph T General Counsel 07/30/2021 15,744
THERO JOHN F President and CEO 07/30/2021 43,901
Berg Aaron CHIEF COMMERCIAL OFFICER 06/30/2021 13,489
Kalb Michael Wayne SVP and CFO 06/30/2021 13,489
Ketchum Steven B Chief Scientific Officer 06/30/2021 14,009
Kennedy Joseph T General Counsel 06/30/2021 17,037
THERO JOHN F President and CEO 06/30/2021 47,506
STACK DAVID M Director 06/04/2021 45,350
STACK DAVID M Director 06/03/2021 23,115
Berg Aaron CHIEF COMMERCIAL OFFICER 05/28/2021 13,674
Kalb Michael Wayne SVP and CFO 05/28/2021 13,597
Kennedy Joseph T General Counsel 05/28/2021 17,266
Berg Aaron CHIEF COMMERCIAL OFFICER 04/30/2021 80,960
Kalb Michael Wayne SVP and CFO 04/30/2021 15,694
Kennedy Joseph T General Counsel 04/30/2021 19,928
Berg Aaron CHIEF COMMERCIAL OFFICER 03/31/2021 19,186
Kalb Michael Wayne SVP and CFO 03/31/2021 19,078
Kennedy Joseph T General Counsel 03/31/2021 24,225
THERO JOHN F President and CEO 03/31/2021 67,547
Berg Aaron CHIEF COMMERCIAL OFFICER 02/26/2021 74,524
Berg Aaron CHIEF COMMERCIAL OFFICER 02/25/2021 318,557
Kalb Michael Wayne SVP and CFO 02/26/2021 74,511
Kalb Michael Wayne SVP and CFO 02/25/2021 316,784
Ketchum Steven B Chief Scientific Officer 02/26/2021 77,395
Ketchum Steven B Chief Scientific Officer 02/25/2021 330,887
Kennedy Joseph T General Counsel 02/26/2021 83,603
Kennedy Joseph T General Counsel 02/25/2021 402,522
THERO JOHN F President and CEO 02/26/2021 228,924
THERO JOHN F President and CEO 02/25/2021 1,122,295
Ketchum Steven B Chief Scientific Officer 02/01/2021 485,882
Ketchum Steven B Chief Scientific Officer 02/01/2021 1,754,134
Berg Aaron CHIEF COMMERCIAL OFFICER 01/29/2021 47,108
Kalb Michael Wayne SVP and CFO 01/29/2021 111,960
Ketchum Steven B Chief Scientific Officer 01/29/2021 161,513
Ketchum Steven B Chief Scientific Officer 01/27/2021 764,566
Ketchum Steven B Chief Scientific Officer 01/27/2021 3,378,131
Kennedy Joseph T General Counsel 01/29/2021 125,333
THERO JOHN F President and CEO 01/29/2021 620,715
Berg Aaron CHIEF COMMERCIAL OFFICER 12/31/2020 7,876
Kalb Michael Wayne SVP and CFO 12/31/2020 7,835
Ketchum Steven B Chief Scientific Officer 12/31/2020 7,876
Kennedy Joseph T General Counsel 12/31/2020 9,947
THERO JOHN F President and CEO 12/31/2020 27,729
Berg Aaron CHIEF COMMERCIAL OFFICER 11/30/2020 6,928
STACK DAVID M Director 11/30/2020 121,518
Kalb Michael Wayne SVP and CFO 11/30/2020 6,891
Ketchum Steven B Chief Scientific Officer 11/30/2020 6,928
Kennedy Joseph T General Counsel 11/30/2020 8,749
THERO JOHN F President and CEO 11/30/2020 24,389
THERO JOHN F President and CEO 11/10/2020 2,091,887
THERO JOHN F President and CEO 11/09/2020 458,113
THERO JOHN F President and CEO 11/10/2020 635,975
THERO JOHN F President and CEO 11/11/2020 1,681,183
Berg Aaron CHIEF COMMERCIAL OFFICER 10/30/2020 7,319
Kalb Michael Wayne SVP and CFO 10/30/2020 7,280
Ketchum Steven B Chief Scientific Officer 10/30/2020 7,319
Kennedy Joseph T General Counsel 10/30/2020 9,244
Zakrzewski Joseph S Director 10/21/2020 340,000
Berg Aaron CHIEF COMMERCIAL OFFICER 09/30/2020 6,084
Ketchum Steven B Chief Scientific Officer 09/30/2020 6,084
Berg Aaron CHIEF COMMERCIAL OFFICER 08/31/2020 11,084
Kalb Michael Wayne SVP and CFO 08/31/2020 11,011
Ketchum Steven B Chief Scientific Officer 08/31/2020 11,084
Kennedy Joseph T General Counsel 08/31/2020 13,999
THERO JOHN F President and CEO 08/31/2020 39,023
Berg Aaron CHIEF COMMERCIAL OFFICER 07/31/2020 9,938
Kalb Michael Wayne SVP and CFO 07/31/2020 9,872
Ketchum Steven B Chief Scientific Officer 07/31/2020 9,938
Kennedy Joseph T General Counsel 07/31/2020 12,547
THERO JOHN F President and CEO 07/31/2020 34,953
THERO JOHN F President and CEO 06/30/2020 35,629
Kennedy Joseph T General Counsel 06/30/2020 12,781
Ketchum Steven B Chief Scientific Officer 06/30/2020 10,120
Kalb Michael Wayne SVP and CFO 06/30/2020 10,053
Berg Aaron CHIEF COMMERCIAL OFFICER 06/30/2020 10,120
Berg Aaron CHIEF COMMERCIAL OFFICER 05/29/2020 10,331
Kalb Michael Wayne SVP and CFO 05/29/2020 10,276
Ketchum Steven B Chief Scientific Officer 05/29/2020 10,331
Kennedy Joseph T General Counsel 05/29/2020 13,048
THERO JOHN F President and CEO 05/29/2020 36,372
Berg Aaron CHIEF COMMERCIAL OFFICER 05/01/2020 97,446
Berg Aaron CHIEF COMMERCIAL OFFICER 04/30/2020 12,440
Kalb Michael Wayne SVP and CFO 04/30/2020 12,373
Ketchum Steven B Chief Scientific Officer 04/30/2020 12,440
Kennedy Joseph T General Counsel 04/30/2020 15,711
THERO JOHN F President and CEO 04/30/2020 43,795
Berg Aaron CHIEF COMMERCIAL OFFICER 03/31/2020 20,451
Kalb Michael Wayne SVP and CFO 03/31/2020 20,343
Ketchum Steven B Chief Scientific Officer 03/31/2020 20,451
THERO JOHN F President and CEO 03/31/2020 72,001
THERO JOHN F President and CEO 03/04/2020 3,198,700
Berg Aaron CHIEF COMMERCIAL OFFICER 02/28/2020 22,093
Kalb Michael Wayne SVP and CFO 02/28/2020 21,976
Ketchum Steven B Chief Scientific Officer 02/28/2020 22,093
THERO JOHN F President and CEO 02/28/2020 77,780
Berg Aaron CHIEF COMMERCIAL OFFICER 02/25/2020 449,802
Kalb Michael Wayne SVP and CFO 02/25/2020 447,235
Ketchum Steven B Chief Scientific Officer 02/25/2020 449,802
Kennedy Joseph T General Counsel 02/25/2020 568,256
THERO JOHN F President and CEO 02/25/2020 1,584,380
THERO JOHN F President and CEO 01/31/2020 2,366,425
Kennedy Joseph T General Counsel 01/31/2020 754,593
Ketchum Steven B Chief Scientific Officer 01/31/2020 639,801
Kalb Michael Wayne SVP and CFO 01/31/2020 636,412
Berg Aaron CHIEF COMMERCIAL OFFICER 01/31/2020 276,975
Zakrzewski Joseph S Director 01/03/2020 1,020,000
Zakrzewski Joseph S Director 01/03/2020 6,282,870
Zakrzewski Joseph S Director 12/16/2019 900,000
Zakrzewski Joseph S Director 12/16/2019 2,583,380
Berg Aaron CHIEF COMMERCIAL OFFICER 12/16/2019 544,988
Kalb Michael Wayne SVP and CFO 12/16/2019 54,750
Berg Aaron CHIEF COMMERCIAL OFFICER 12/16/2019 1,101,364
Kalb Michael Wayne SVP and CFO 12/16/2019 584,012
THERO JOHN F President and CEO 11/19/2019 6,217,371
Ekman Lars Director 11/12/2019 555,840
Ekman Lars Director 11/12/2019 746,759
THERO JOHN F President and CEO 11/11/2019 8,143,452
Ekman Lars Director 11/05/2019 92,160
Ekman Lars Director 11/05/2019 115,230
THERO JOHN F President and CEO 10/28/2019 29,003
THERO JOHN F President and CEO 10/07/2019 7,154,478
Ketchum Steven B Chief Scientific Officer 10/07/2019 1,437,330
Kennedy Joseph T General Counsel 10/07/2019 1,509,382
Berg Aaron CHIEF COMMERCIAL OFFICER 10/07/2019 1,466,387
Ekman Lars Director 09/03/2019 320,280
Ekman Lars Director 09/03/2019 1,365,722
THERO JOHN F President and CEO 08/21/2019 62,498
THERO JOHN F President and CEO 08/21/2019 300,010
STACK DAVID M Director 07/11/2019 121,035
STACK DAVID M Director 07/11/2019 1,158,354
Zakrzewski Joseph S Director 07/05/2019 900,000
Zakrzewski Joseph S Director 07/05/2019 2,381,580
Kennedy Joseph T General Counsel 07/01/2019 69,962
Kennedy Joseph T General Counsel 07/01/2019 1,057,906
Kalb Michael Wayne SVP and CFO 07/01/2019 109,500
Kalb Michael Wayne SVP and CFO 07/01/2019 983,270
Berg Aaron CHIEF COMMERCIAL OFFICER 07/02/2019 173,910
Berg Aaron CHIEF COMMERCIAL OFFICER 07/03/2019 81,900
Berg Aaron CHIEF COMMERCIAL OFFICER 07/03/2019 662,238
Berg Aaron CHIEF COMMERCIAL OFFICER 07/02/2019 1,442,141
Kennedy Joseph T General Counsel 06/30/2019 513,738
THERO JOHN F President and CEO 06/30/2019 286,138
Berg Aaron CHIEF COMMERCIAL OFFICER 06/24/2019 250,000
Berg Aaron CHIEF COMMERCIAL OFFICER 06/24/2019 2,104,521
Zakrzewski Joseph S Director 06/18/2019 340,000
Zakrzewski Joseph S Director 06/18/2019 1,902,090
Kennedy Joseph T General Counsel 05/31/2019 69,925
Kennedy Joseph T General Counsel 05/31/2019 488,058
STACK DAVID M Director 05/29/2019 108,495
STACK DAVID M Director 05/29/2019 623,534
STACK DAVID M Director 05/17/2019 42,289
STACK DAVID M Director 05/17/2019 237,139
Ketchum Steven B Chief Scientific Officer 04/30/2019 22,235
Ketchum Steven B Chief Scientific Officer 04/30/2019 178,107
Kennedy Joseph T General Counsel 04/30/2019 69,927
Kennedy Joseph T General Counsel 04/30/2019 508,839
Berg Aaron CHIEF COMMERCIAL OFFICER 05/01/2019 239,454
THERO JOHN F President and CEO 03/31/2019 306,355
Ketchum Steven B Chief Scientific Officer 04/01/2019 22,236
Ketchum Steven B Chief Scientific Officer 04/01/2019 191,392
Kennedy Joseph T General Counsel 03/31/2019 550,036
Kennedy Joseph T General Counsel 04/01/2019 69,926
Kennedy Joseph T General Counsel 04/01/2019 1,086,122
THERO JOHN F President and CEO 03/04/2019 5,327,234
Ekman Lars Director 03/04/2019 276,743
Ekman Lars Director 03/04/2019 2,884,905
Ketchum Steven B Chief Scientific Officer 03/01/2019 115,000
Ketchum Steven B Chief Scientific Officer 02/28/2019 22,239
Ketchum Steven B Chief Scientific Officer 02/28/2019 197,249
Ketchum Steven B Chief Scientific Officer 03/01/2019 1,016,275
Kalb Michael Wayne SVP and CFO 03/01/2019 283,350
Kalb Michael Wayne SVP and CFO 03/01/2019 2,209,098
Kennedy Joseph T General Counsel 02/28/2019 69,928
Kennedy Joseph T General Counsel 02/28/2019 564,172
Zakrzewski Joseph S Director 02/22/2019 1,572,312
Zakrzewski Joseph S Director 02/22/2019 3,594,437
VAN HEEK G JAN Director 02/22/2019 857,170
VAN HEEK G JAN Director 02/22/2019 4,071,423
Peterson Kristine Director 02/22/2019 947,730
Peterson Kristine Director 02/22/2019 3,274,038
Kalb Michael Wayne SVP and CFO 02/22/2019 147,500
Kalb Michael Wayne SVP and CFO 02/22/2019 948,500
Kalb Michael Wayne SVP and CFO 02/15/2019 439,525
THERO JOHN F President and CEO 01/31/2019 2,425,418
Ketchum Steven B Chief Scientific Officer 01/31/2019 685,765
Ketchum Steven B Chief Scientific Officer 01/31/2019 22,235
Ketchum Steven B Chief Scientific Officer 02/01/2019 477,498
Ketchum Steven B Chief Scientific Officer 01/31/2019 166,875
Kennedy Joseph T General Counsel 01/31/2019 744,716
Kennedy Joseph T General Counsel 01/31/2019 71,910
Kennedy Joseph T General Counsel 01/31/2019 745,468
Kalb Michael Wayne SVP and CFO 01/31/2019 456,279
Kennedy Joseph T General Counsel 01/23/2019 1,840,134
Kennedy Joseph T General Counsel 01/22/2019 804,656
Kennedy Joseph T General Counsel 01/24/2019 2,370,612
Kennedy Joseph T General Counsel 01/23/2019 4,591,310
Kennedy Joseph T General Counsel 01/22/2019 3,141,884
Kennedy Joseph T General Counsel 01/24/2019 10,754,717
Zakrzewski Joseph S Director 01/10/2019 680,000
Zakrzewski Joseph S Director 01/10/2019 3,396,390
STACK DAVID M Director 01/10/2019 577,855
STACK DAVID M Director 01/10/2019 79,172
STACK DAVID M Director 01/10/2019 1,774,296
STACK DAVID M Director 01/10/2019 484,776
Kennedy Joseph T General Counsel 01/11/2019 9,360
Kennedy Joseph T General Counsel 01/11/2019 60,033
Kalb Michael Wayne SVP and CFO 01/09/2019 438,000
Kalb Michael Wayne SVP and CFO 01/09/2019 3,051,080
Ekman Lars Director 01/10/2019 103,428
Ekman Lars Director 01/10/2019 2,426,489
Zakrzewski Joseph S Director 01/02/2019 1,237,250
Zakrzewski Joseph S Director 01/02/2019 5,015,703
Zakrzewski Joseph S Director 12/28/2018 1,866,668
Kennedy Joseph T General Counsel 12/31/2018 350,794
Kennedy Joseph T General Counsel 12/31/2018 363,547
Ketchum Steven B Chief Scientific Officer 12/31/2018 40,985
Ketchum Steven B Chief Scientific Officer 12/31/2018 230,212
THERO JOHN F President and CEO 12/31/2018 195,383
Ketchum Steven B Chief Scientific Officer 11/30/2018 40,988
Ketchum Steven B Chief Scientific Officer 11/30/2018 303,174
Kennedy Joseph T General Counsel 11/30/2018 52,510
Kennedy Joseph T General Counsel 11/30/2018 414,998
THERO JOHN F President and CEO 11/12/2018 550,275
THERO JOHN F President and CEO 11/12/2018 11,587,896
Ketchum Steven B Chief Scientific Officer 10/31/2018 40,988
Ketchum Steven B Chief Scientific Officer 10/31/2018 353,454
Kennedy Joseph T General Counsel 10/31/2018 52,513
Kennedy Joseph T General Counsel 10/31/2018 483,362
THERO JOHN F President and CEO 09/30/2018 240,096
Ketchum Steven B Chief Scientific Officer 09/28/2018 1,754,000
Ketchum Steven B Chief Scientific Officer 10/01/2018 916,893
Ketchum Steven B Chief Scientific Officer 09/28/2018 3,100,000
Ketchum Steven B Chief Scientific Officer 10/01/2018 2,005,589
Kennedy Joseph T General Counsel 09/30/2018 431,074
Kennedy Joseph T General Counsel 10/01/2018 52,510
Kennedy Joseph T General Counsel 10/01/2018 844,528
Zakrzewski Joseph S Director 09/24/2018 1,700,000
Zakrzewski Joseph S Director 09/24/2018 5,299,334
Ketchum Steven B Chief Scientific Officer 09/25/2018 1,754,000
Ketchum Steven B Chief Scientific Officer 09/24/2018 2,366,711
Ketchum Steven B Chief Scientific Officer 09/25/2018 2,700,000
Ketchum Steven B Chief Scientific Officer 09/24/2018 7,060,024
Kennedy Joseph T General Counsel 09/24/2018 2,393,014
Kennedy Joseph T General Counsel 09/24/2018 11,400,975
Kalb Michael Wayne SVP and CFO 09/24/2018 328,500
Kalb Michael Wayne SVP and CFO 09/24/2018 1,562,751
THERO JOHN F President and CEO 09/22/2018 1,488,649
THERO JOHN F President and CEO 06/30/2018 45,599
Kennedy Joseph T General Counsel 06/30/2018 81,870
Kennedy Joseph T General Counsel 07/02/2018 80,955
THERO JOHN F President and CEO 03/31/2018 44,419
Kennedy Joseph T General Counsel 03/31/2018 79,750
Kennedy Joseph T General Counsel 04/03/2018 55,052
Kennedy Joseph T General Counsel 04/02/2018 23,020
THERO JOHN F President and CEO 01/31/2018 756,475
Ketchum Steven B Chief Scientific Officer 01/31/2018 219,949
Kennedy Joseph T General Counsel 01/31/2018 230,999
Kennedy Joseph T General Counsel 01/31/2018 167,388
Kalb Michael Wayne SVP and CFO 01/31/2018 53,635
Ketchum Steven B Chief Scientific Officer 01/23/2018 275,818
Ketchum Steven B Chief Scientific Officer 01/23/2018 596,430
Kennedy Joseph T General Counsel 01/12/2018 41,128
Kennedy Joseph T General Counsel 01/17/2018 127,022
Kennedy Joseph T General Counsel 01/16/2018 41,300
Ketchum Steven B Chief Scientific Officer 01/11/2018 5,328
Ketchum Steven B Chief Scientific Officer 01/11/2018 11,493
Ketchum Steven B Chief Scientific Officer 01/05/2018 131,953
Ketchum Steven B Chief Scientific Officer 01/05/2018 284,631
Ketchum Steven B Chief Scientific Officer 01/02/2018 153,583
Ketchum Steven B Chief Scientific Officer 01/02/2018 545,092
THERO JOHN F President and CEO 12/31/2017 63,085
Kennedy Joseph T General Counsel 12/31/2017 111,819
THERO JOHN F President and CEO 11/30/2017 32,446
Ketchum Steven B Chief Scientific Officer 10/05/2017 221,199
THERO JOHN F President and CEO 09/30/2017 55,062
Kennedy Joseph T General Counsel 09/30/2017 97,598
THERO JOHN F President and CEO 06/30/2017 63,400
Kennedy Joseph T General Counsel 06/30/2017 112,377
Kennedy Joseph T General Counsel 06/29/2017 603,824
Kennedy Joseph T General Counsel 07/03/2017 209,158
Kennedy Joseph T General Counsel 06/30/2017 417,950
Kennedy Joseph T General Counsel 03/31/2017 86,339
THERO JOHN F President and CEO 03/31/2017 50,342
THERO JOHN F President and CEO 01/31/2017 688,202
Ketchum Steven B Chief Scientific Officer 01/31/2017 208,601
Kennedy Joseph T General Counsel 01/31/2017 225,349
Kennedy Joseph T General Counsel 12/31/2016 85,886
THERO JOHN F President and CEO 12/31/2016 62,198
Kennedy Joseph T General Counsel 11/09/2016 372,042
Kennedy Joseph T General Counsel 09/30/2016 88,953
THERO JOHN F President and CEO 09/30/2016 64,419
THERO JOHN F President and CEO 06/30/2016 31,793
Kennedy Joseph T General Counsel 06/30/2016 60,232
Kennedy Joseph T General Counsel 03/31/2016 30,725
THERO JOHN F President and CEO 03/31/2016 22,520
THERO JOHN F President and CEO 02/01/2016 34,250
THERO JOHN F President and CEO 01/31/2016 234,134
Ketchum Steven B Chief Scientific Officer 01/31/2016 57,842
Kennedy Joseph T General Counsel 01/31/2016 64,710
Farrell Michael James VP, Finance 01/31/2016 15,772
Kennedy Joseph T General Counsel 12/31/2015 37,955
Kennedy Joseph T General Counsel 10/05/2015 4,815
Kennedy Joseph T General Counsel 09/30/2015 34,227
THERO JOHN F President and CEO 08/11/2015 47,000
Farrell Michael James Controller 11/11/2014 4,606
THERO JOHN F President, Chief Exec. Officer 11/12/2014 17,600
THERO JOHN F President, Chief Exec. Officer 11/11/2014 24,000
Ekman Lars Director 11/20/2013 72,000
THERO JOHN F President 11/20/2013 9,500
Zakrzewski Joseph S Chief Executive Officer 11/18/2013 78,197
VAN HEEK G JAN Director 07/10/2013 9,810
Zakrzewski Joseph S Chief Executive Officer 06/25/2013 13,500
Zakrzewski Joseph S Chief Executive Officer 06/21/2013 13,500
THERO JOHN F President 05/29/2013 14,850
Zakrzewski Joseph S Chief Executive Officer 04/25/2013 13,500
VAN HEEK G JAN Director 04/10/2013 9,808
THERO JOHN F President 01/30/2013 13,500
VAN HEEK G JAN Director 01/10/2013 7,935
VAN HEEK G JAN Director 10/10/2012 7,930
Zakrzewski Joseph S Chief Executive Officer 10/01/2012 202,500
Zakrzewski Joseph S Chief Executive Officer 10/01/2012 1,884,315
THERO JOHN F President 09/24/2012 13,500
THERO JOHN F President 09/11/2012 13,500
HEALY JAMES Director 08/31/2012 30,900
GORDON CARL L Director 09/04/2012 3,372,992
ORBIMED ADVISORS LLC Director 09/04/2012 3,372,992
HEALY JAMES Director 08/14/2012 1,212,300
GORDON CARL L Director 07/27/2012 5,350,691
ORBIMED ADVISORS LLC Director 07/27/2012 50,483
ORBIMED ADVISORS LLC Director 07/27/2012 5,300,207
Zakrzewski Joseph S Chief Executive Officer 07/27/2012 202,500
Zakrzewski Joseph S Chief Executive Officer 07/27/2012 2,147,192
THERO JOHN F President 07/27/2012 713,750
THERO JOHN F President 07/27/2012 4,315,862
Kennedy Joseph T Senior VP and General Counsel 07/27/2012 96,290
Huff Paul Chief Commercial Officer 07/27/2012 96,290
SEDLACK STUART D Senior Vice President 07/27/2012 96,290
VAN HEEK G JAN Director 07/10/2012 7,934
Huff Paul Chief Commercial Officer 06/26/2012 9,669
Huff Paul Chief Commercial Officer 06/27/2012 429,831
Huff Paul Chief Commercial Officer 06/26/2012 14,870
Huff Paul Chief Commercial Officer 06/27/2012 734,204
GORDON CARL L Director 06/19/2012 7,986,701
ORBIMED ADVISORS LLC Director 06/19/2012 76,185
ORBIMED ADVISORS LLC Director 06/19/2012 7,892,242
Huff Paul Chief Commercial Officer 06/18/2012 1,432,111
Huff Paul Chief Commercial Officer 06/15/2012 879
Huff Paul Chief Commercial Officer 06/15/2012 1,200
Huff Paul Chief Commercial Officer 06/18/2012 1,955,524
Huff Paul Chief Commercial Officer 06/07/2012 111,008
Huff Paul Chief Commercial Officer 06/07/2012 201,635
Zakrzewski Joseph S Chief Executive Officer 05/29/2012 202,500
Zakrzewski Joseph S Chief Executive Officer 05/29/2012 1,795,215
Abingworth LLP 10% Owner 04/19/2012 6,586,347
Abingworth LLP 10% Owner 04/18/2012 15,505,584
Abingworth LLP 10% Owner 04/17/2012 16,454,204
Abingworth LLP 10% Owner 04/18/2012 15,505,584
Abingworth LLP 10% Owner 04/17/2012 16,454,204
Abingworth LLP 10% Owner 04/19/2012 6,586,347
VAN HEEK G JAN Director 04/10/2012 7,929
THERO JOHN F President 04/09/2012 203,750
THERO JOHN F President 04/09/2012 1,503,072
Abingworth LLP 10% Owner 04/03/2012 25,300,000
HEALY JAMES Director 04/03/2012 19,059,665
HEALY JAMES Director 04/02/2012 2,905,286
HEALY JAMES Director 03/29/2012 10,910,804
HEALY JAMES Director 03/28/2012 73,922
Zakrzewski Joseph S Chief Executive Officer 03/23/2012 216,000
Zakrzewski Joseph S Chief Executive Officer 03/23/2012 1,854,560
HEALY JAMES Director 01/27/2012 61,800
VAN HEEK G JAN Director 01/10/2012 6,312
Zakrzewski Joseph S Chief Executive Officer 11/07/2011 6,750
VAN HEEK G JAN Director 10/11/2011 6,307
Anderson Joseph Director 10/11/2011 7,879
Zakrzewski Joseph S Chief Executive Officer 08/22/2011 6,750
Zakrzewski Joseph S Chief Executive Officer 07/15/2011 6,750
Zakrzewski Joseph S Chief Executive Officer 07/15/2011 6,750
VAN HEEK G JAN Director 07/11/2011 6,310
Anderson Joseph Director 07/11/2011 6,636
Anderson Joseph Director 10/11/2010 6,387
Anderson Joseph Director 07/12/2010 6,386
Anderson Joseph Director 04/12/2010 6,386
Anderson Joseph Director 04/11/2011 6,384
Anderson Joseph Director 01/10/2011 6,378
VAN HEEK G JAN Director 04/11/2011 6,307
ORBIMED ADVISORS LLC Director 05/02/2011 4,890
ORBIMED ADVISORS LLC Director 05/02/2011 531,380
ORBIMED ADVISORS LLC Director 04/29/2011 16,010
ORBIMED ADVISORS LLC Director 04/29/2011 1,584,990
GORDON CARL L Director 04/29/2011 1,601,000
GORDON CARL L Director 05/02/2011 536,270
VAN HEEK G JAN Director 04/25/2011 30,900
VAN HEEK G JAN Director 04/25/2011 497,379
VAN HEEK G JAN Director 04/18/2011 3,090
ORBIMED ADVISORS LLC Director 04/20/2011 120,004
ORBIMED ADVISORS LLC Director 04/20/2011 12,511,996
GORDON CARL L Director 04/20/2011 120,004
GORDON CARL L Director 04/20/2011 12,511,996
GORDON CARL L Director 04/21/2011 12,500,000
ORBIMED ADVISORS LLC Director 04/21/2011 118,333
ORBIMED ADVISORS LLC Director 04/21/2011 12,381,667
GORDON CARL L Director 04/20/2011 12,632,000
GORDON CARL L Director 04/18/2011 45,549,897
ORBIMED ADVISORS LLC Director 04/20/2011 12,632,000
ORBIMED ADVISORS LLC Director 04/18/2011 428,168
ORBIMED ADVISORS LLC Director 04/18/2011 45,121,729
Zakrzewski Joseph S Chief Executive Officer 04/18/2011 815,000
Zakrzewski Joseph S Chief Executive Officer 04/18/2011 4,728,210
VAN HEEK G JAN Director 04/18/2011 3,090
VAN HEEK G JAN Director 04/18/2011 49,530
Soni Paresh SVP and Head of Development 04/19/2011 108,000
Soni Paresh SVP and Head of Development 04/19/2011 1,208,624
Ahlholm Frederick W Vice President Finance 04/20/2011 53,125
Ahlholm Frederick W Vice President Finance 04/20/2011 496,344
Abingworth LLP 10% Owner 04/18/2011 62,143,480