Amarin Corp. (AMRN) NASDAQ
$0.92 (0) (-0.35%)
Market Cap: $90.76M
As of 04/16/24 10:27 AM EDT. Market open.
Amarin Corp. (AMRN)
NASDAQ
$0.92
(0) (-0.35%)
Market Cap: $90.76M
As of 04/16/24 10:27 AM EDT. Market open.
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amarin corporation plc is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health. amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids. vascepa® (icosapent ethyl) is amarin's first fda approved product and is available in ... read more
amarin corporation plc is a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health. amarin's product development program leverages its extensive experience in lipid science and the potential therapeutic benefits of polyunsaturated fatty acids. vascepa® (icosapent ethyl) is amarin's first fda approved product and is available in the united states by prescription. for more information about vascepa visit www.vascepa.com. read less
COMPANY PROFILE
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
John Thero
Full Time Employees
647
Sector
Manufacturing
Industry
Pharmaceutical Preparation Manufacturing
CEO
John Thero
Full Time Employees
647
Address
Shelbourne Road Ballsbridge, First Floor Block 3 The Oval, DUBLIN.
PRICE CHART FOR AMARIN CORP
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NEWS
INSIDEARBITRAGE ARTICLES
KEY STATS
Open
$0.92
Previous Close
$0.92
Days Range
$0.91 - $0.97
52 week range
$0.65 - $1.49
Volume
194,879
Avg. Volume (30 days)
1,324,216
Market Cap
$90.76M
Dividend Yield
-
P/E
-
Shares Outstanding
98,801,982
Open
$0.92
Previous Close
$0.92
Days Range
$0.91 - $0.97
52 week range
$0.65 - $1.49
Volume
194,879
Avg. Volume (30 days)
1,324,216
Market Cap
$90.76M
Dividend Yield
-
P/E
-
Shares Outstanding
98,801,982
FINANCIAL STATEMENTS FOR AMARIN CORP
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INSIDER TRANSACTIONS FOR AMARIN CORP
| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Berg Aaron | EVP, President US | Jan 31, 2024 | Option Exercise | $1.24 | 40,822 | 50,619 | 633,260 | Feb 02, 2024, 04:30 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2024 | Option Exercise | $1.24 | 41,187 | 51,072 | 658,720 | Feb 02, 2024, 04:30 PM |
| Reilly Thomas Charles | EVP and CFO | Jan 31, 2024 | Option Exercise | $1.24 | 24,552 | 30,444 | 68,931 | Feb 02, 2024, 04:30 PM |
| Holt Patrick | President and CEO | Jan 22, 2024 | Buy | $1.09 | 14,426 | 15,724 | 314,426 | Jan 24, 2024, 04:31 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 10, 2024 | Option Exercise | $0.97 | 28,270 | 27,422 | 620,407 | Jan 12, 2024, 05:31 PM |
| Reilly Thomas Charles | EVP and CFO | Jan 10, 2024 | Option Exercise | $0.97 | 28,325 | 27,475 | 48,550 | Jan 12, 2024, 05:27 PM |
| Berg Aaron | EVP, President US | Jan 10, 2024 | Option Exercise | $0.97 | 28,214 | 27,368 | 594,582 | Jan 12, 2024, 05:25 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 04, 2024 | Option Exercise | $0.87 | 7,730 | 6,725 | 597,177 | Jan 08, 2024, 06:03 PM |
| Berg Aaron | EVP, President US | Jan 04, 2024 | Option Exercise | $0.87 | 15,460 | 13,450 | 571,296 | Jan 08, 2024, 06:03 PM |
| Ketchum Steven B | Chief Scientific Officer | Dec 29, 2023 | Option Exercise | $0.87 | 23,525 | 20,467 | 590,341 | Jan 02, 2024, 04:47 PM |
| Berg Aaron | EVP, President US | Dec 29, 2023 | Option Exercise | $0.87 | 23,525 | 20,467 | 557,623 | Jan 02, 2024, 04:43 PM |
| Ketchum Steven B | Chief Scientific Officer | Dec 12, 2023 | Sale | $0.79 | 34,131 | 26,963 | 566,100 | Dec 14, 2023, 06:35 PM |
| Holt Patrick | President and CEO | Aug 16, 2023 | Buy | $1.04 | 300,000 | 312,315 | 300,000 | Aug 16, 2023, 07:51 PM |
| Berg Aaron | EVP, President US | Jul 31, 2023 | Option Exercise | $1.19 | 11,763 | 13,998 | 533,382 | Aug 02, 2023, 05:01 PM |
| Ketchum Steven B | Chief Scientific Officer | Jul 31, 2023 | Option Exercise | $1.19 | 11,763 | 13,998 | 600,231 | Aug 02, 2023, 05:00 PM |
| Reilly Thomas Charles | SVP and CFO | Jul 01, 2023 | Option Exercise | $1.19 | 8,209 | 9,769 | 25,375 | Jul 05, 2023, 04:46 PM |
| Reilly Thomas Charles | SVP and CFO | Jun 20, 2023 | Option Exercise | $1.19 | 16,417 | 19,536 | 16,917 | Jun 22, 2023, 05:10 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 28, 2023 | Option Exercise | $2.03 | 7,718 | 15,668 | 588,111 | Mar 08, 2023, 08:30 AM |
| Berg Aaron | EVP, President US | Feb 28, 2023 | Option Exercise | $2.03 | 7,718 | 15,668 | 510,760 | Mar 08, 2023, 08:30 AM |
| Berg Aaron | EVP, President US | Feb 21, 2023 | Option Exercise | $1.80 | 28,162 | 50,692 | 502,145 | Feb 23, 2023, 09:43 PM |
| Berg Aaron | EVP, President US | Jan 31, 2023 | Option Exercise | $1.86 | 13,707 | 25,495 | 472,040 | Feb 23, 2023, 09:43 PM |
| Mikhail Karim | President and CEO | Feb 21, 2023 | Option Exercise | $1.80 | 10,001 | 18,002 | 283,507 | Feb 23, 2023, 09:40 PM |
| Mikhail Karim | President and CEO | Jan 31, 2023 | Option Exercise | $1.86 | 62,310 | 115,897 | 260,174 | Feb 23, 2023, 09:40 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 21, 2023 | Option Exercise | $1.80 | 14,520 | 26,136 | 579,496 | Feb 23, 2023, 09:39 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2023 | Option Exercise | $1.86 | 13,706 | 25,493 | 564,882 | Feb 23, 2023, 09:39 PM |
| Berg Aaron | EVP, President US | Dec 30, 2022 | Option Exercise | $1.21 | 16,361 | 19,797 | 451,180 | Jan 04, 2023, 08:41 PM |
| Ketchum Steven B | Chief Scientific Officer | Dec 30, 2022 | Option Exercise | $1.21 | 16,361 | 19,797 | 544,021 | Jan 04, 2023, 08:41 PM |
| Mikhail Karim | President and CEO | Dec 30, 2022 | Option Exercise | $1.21 | 1,270 | 1,537 | 114,784 | Jan 04, 2023, 08:26 PM |
| Marks Jason M. | EVP,Chief Global Legal Officer | Aug 19, 2022 | Option Exercise | $1.60 | 11,417 | 18,267 | 21,917 | Aug 23, 2022, 08:02 PM |
| Kalb Michael Wayne | SVP and CFO | Aug 01, 2022 | Option Exercise | $1.33 | 29,682 | 39,477 | 337,314 | Aug 02, 2022, 08:07 PM |
| Kalb Michael Wayne | SVP and CFO | Jul 29, 2022 | Option Exercise | $1.33 | 17,220 | 22,903 | 284,662 | Aug 02, 2022, 08:07 PM |
| Berg Aaron | EVP, President US | Jul 29, 2022 | Option Exercise | $1.33 | 8,181 | 10,881 | 411,155 | Aug 02, 2022, 08:07 PM |
| Ketchum Steven B | Chief Scientific Officer | Jul 29, 2022 | Option Exercise | $1.33 | 8,181 | 10,881 | 512,615 | Aug 02, 2022, 08:07 PM |
| Mikhail Karim | President and CEO | Jul 01, 2022 | Option Exercise | $1.49 | 10,780 | 16,062 | 104,687 | Jul 06, 2022, 08:12 PM |
| WOLD OLSEN PER | Director | Jun 13, 2022 | Buy | $1.69 | 55,000 | 92,730 | 149,000 | Jun 15, 2022, 08:01 PM |
| Mikhail Karim | President and CEO | Apr 12, 2022 | Option Exercise | $3.35 | 20,631 | 69,114 | 82,134 | Apr 14, 2022, 08:02 PM |
| Kalb Michael Wayne | SVP and CFO | Feb 28, 2022 | Option Exercise | $3.27 | 6,213 | 20,317 | 250,747 | Mar 02, 2022, 08:03 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 28, 2022 | Option Exercise | $3.27 | 5,508 | 18,011 | 496,912 | Mar 02, 2022, 08:01 PM |
| Kalb Michael Wayne | SVP and CFO | Jan 31, 2022 | Option Exercise | $3.36 | 5,317 | 17,865 | 240,627 | Feb 02, 2022, 08:03 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2022 | Option Exercise | $3.36 | 5,121 | 17,207 | 486,087 | Feb 02, 2022, 08:01 PM |
| Kalb Michael Wayne | SVP and CFO | Dec 31, 2021 | Option Exercise | $3.35 | 25,379 | 85,020 | 233,211 | Jan 04, 2022, 09:08 PM |
| Mikhail Karim | President and CEO | Dec 31, 2021 | Option Exercise | $3.35 | 3,876 | 12,985 | 31,031 | Jan 04, 2022, 09:06 PM |
| Zakrzewski Joseph S | Director | Dec 15, 2021 | Buy | $3.15 | 2,000 | 6,310 | 196,547 | Dec 16, 2021, 08:01 PM |
| Zakrzewski Joseph S | Director | Dec 14, 2021 | Buy | $3.27 | 10,000 | 32,689 | 194,547 | Dec 16, 2021, 08:01 PM |
| Berg Aaron | EVP, President US | Aug 31, 2021 | Option Exercise | $5.54 | 3,011 | 16,681 | 315,251 | Sep 02, 2021, 08:07 PM |
| Kalb Michael Wayne | SVP and CFO | Aug 31, 2021 | Option Exercise | $5.54 | 3,011 | 16,681 | 208,107 | Sep 02, 2021, 08:04 PM |
| Ketchum Steven B | Chief Scientific Officer | Aug 31, 2021 | Option Exercise | $5.54 | 3,127 | 17,324 | 455,141 | Sep 02, 2021, 08:01 PM |
| Kalb Michael Wayne | SVP and CFO | Aug 12, 2021 | Option Exercise | $2.35 | 120,000 | 281,800 | 325,010 | Aug 13, 2021, 08:04 PM |
| Kalb Michael Wayne | SVP and CFO | Aug 12, 2021 | Sale | $5.25 | 120,000 | 630,240 | 205,010 | Aug 13, 2021, 08:04 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jul 30, 2021 | Option Exercise | $4.14 | 3,011 | 12,466 | 312,154 | Aug 03, 2021, 08:12 PM |
| Kalb Michael Wayne | SVP and CFO | Jul 30, 2021 | Option Exercise | $4.14 | 3,011 | 12,466 | 205,010 | Aug 03, 2021, 08:10 PM |
| Ketchum Steven B | Chief Scientific Officer | Jul 30, 2021 | Option Exercise | $4.14 | 3,127 | 12,946 | 452,160 | Aug 03, 2021, 08:08 PM |
| Kennedy Joseph T | General Counsel | Jul 30, 2021 | Option Exercise | $4.14 | 3,803 | 15,744 | 317,860 | Aug 03, 2021, 08:05 PM |
| THERO JOHN F | President and CEO | Jul 30, 2021 | Option Exercise | $4.14 | 10,604 | 43,901 | 3,252,752 | Aug 03, 2021, 08:02 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jun 30, 2021 | Option Exercise | $4.48 | 3,011 | 13,489 | 309,057 | Jul 02, 2021, 08:12 PM |
| Kalb Michael Wayne | SVP and CFO | Jun 30, 2021 | Option Exercise | $4.48 | 3,011 | 13,489 | 201,913 | Jul 02, 2021, 08:11 PM |
| Ketchum Steven B | Chief Scientific Officer | Jun 30, 2021 | Option Exercise | $4.48 | 3,127 | 14,009 | 449,179 | Jul 02, 2021, 08:09 PM |
| Kennedy Joseph T | General Counsel | Jun 30, 2021 | Option Exercise | $4.48 | 3,803 | 17,037 | 314,443 | Jul 02, 2021, 08:07 PM |
| THERO JOHN F | President and CEO | Jun 30, 2021 | Option Exercise | $4.48 | 10,604 | 47,506 | 3,236,412 | Jul 02, 2021, 08:04 PM |
| STACK DAVID M | Director | Jun 04, 2021 | Buy | $4.53 | 10,000 | 45,350 | 40,000 | Jun 07, 2021, 09:53 PM |
| STACK DAVID M | Director | Jun 03, 2021 | Buy | $4.62 | 5,000 | 23,115 | 30,000 | Jun 07, 2021, 09:53 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | May 28, 2021 | Option Exercise | $4.54 | 3,012 | 13,674 | 305,960 | May 28, 2021, 08:06 PM |
| Kalb Michael Wayne | SVP and CFO | May 28, 2021 | Option Exercise | $4.54 | 2,995 | 13,597 | 198,816 | May 28, 2021, 08:06 PM |
| Kennedy Joseph T | General Counsel | May 28, 2021 | Option Exercise | $4.54 | 3,803 | 17,266 | 311,026 | May 28, 2021, 08:03 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Apr 30, 2021 | Option Exercise | $5.12 | 15,817 | 80,960 | 302,860 | Apr 30, 2021, 08:10 PM |
| Kalb Michael Wayne | SVP and CFO | Apr 30, 2021 | Option Exercise | $5.24 | 2,995 | 15,694 | 193,154 | Apr 30, 2021, 08:09 PM |
| Kennedy Joseph T | General Counsel | Apr 30, 2021 | Option Exercise | $5.24 | 3,803 | 19,928 | 307,609 | Apr 30, 2021, 08:05 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Mar 31, 2021 | Option Exercise | $6.37 | 3,012 | 19,186 | 286,565 | Apr 02, 2021, 08:09 PM |
| Kalb Michael Wayne | SVP and CFO | Mar 31, 2021 | Option Exercise | $6.37 | 2,995 | 19,078 | 190,037 | Apr 02, 2021, 08:07 PM |
| Kennedy Joseph T | General Counsel | Mar 31, 2021 | Option Exercise | $6.37 | 3,803 | 24,225 | 304,192 | Apr 02, 2021, 08:05 PM |
| THERO JOHN F | President and CEO | Mar 31, 2021 | Option Exercise | $6.37 | 10,604 | 67,547 | 3,187,392 | Apr 02, 2021, 08:04 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Feb 26, 2021 | Option Exercise | $6.74 | 11,057 | 74,524 | 283,465 | Mar 01, 2021, 08:06 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Feb 25, 2021 | Option Exercise | $7.30 | 43,638 | 318,557 | 272,076 | Mar 01, 2021, 08:06 PM |
| Kalb Michael Wayne | SVP and CFO | Feb 25, 2021 | Option Exercise | $7.30 | 43,395 | 316,784 | 175,529 | Mar 01, 2021, 08:05 PM |
| Kalb Michael Wayne | SVP and CFO | Feb 26, 2021 | Option Exercise | $6.74 | 11,055 | 74,511 | 186,920 | Mar 01, 2021, 08:05 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 26, 2021 | Option Exercise | $6.74 | 11,483 | 77,395 | 437,246 | Mar 01, 2021, 08:04 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 25, 2021 | Option Exercise | $7.30 | 45,327 | 330,887 | 426,283 | Mar 01, 2021, 08:04 PM |
| Kennedy Joseph T | General Counsel | Feb 26, 2021 | Option Exercise | $6.74 | 12,404 | 83,603 | 300,775 | Mar 01, 2021, 08:03 PM |
| Kennedy Joseph T | General Counsel | Feb 25, 2021 | Option Exercise | $7.30 | 55,140 | 402,522 | 289,621 | Mar 01, 2021, 08:03 PM |
| THERO JOHN F | President and CEO | Feb 26, 2021 | Option Exercise | $6.74 | 33,965 | 228,924 | 3,171,052 | Mar 01, 2021, 08:02 PM |
| THERO JOHN F | President and CEO | Feb 25, 2021 | Option Exercise | $7.30 | 153,739 | 1,122,295 | 3,118,706 | Mar 01, 2021, 08:02 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 01, 2021 | Option Exercise | $2.53 | 192,358 | 485,882 | 600,724 | Feb 03, 2021, 08:02 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 01, 2021 | Sale | $8.06 | 217,728 | 1,754,134 | 408,366 | Feb 03, 2021, 08:02 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jan 29, 2021 | Option Exercise | $7.50 | 6,281 | 47,108 | 227,100 | Jan 29, 2021, 08:05 PM |
| Kalb Michael Wayne | SVP and CFO | Jan 29, 2021 | Option Exercise | $7.50 | 14,928 | 111,960 | 130,310 | Jan 29, 2021, 08:04 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 29, 2021 | Option Exercise | $7.50 | 21,535 | 161,513 | 408,366 | Jan 29, 2021, 08:03 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 27, 2021 | Option Exercise | $2.75 | 278,237 | 764,566 | 809,741 | Jan 29, 2021, 08:03 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 27, 2021 | Sale | $8.01 | 421,629 | 3,378,131 | 531,504 | Jan 29, 2021, 08:03 PM |
| Kennedy Joseph T | General Counsel | Jan 29, 2021 | Option Exercise | $7.50 | 16,711 | 125,333 | 240,033 | Jan 29, 2021, 08:02 PM |
| THERO JOHN F | President and CEO | Jan 29, 2021 | Option Exercise | $7.50 | 82,762 | 620,715 | 2,881,749 | Jan 29, 2021, 08:01 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Dec 31, 2020 | Option Exercise | $5.23 | 1,506 | 7,876 | 217,592 | Jan 05, 2021, 08:05 PM |
| Kalb Michael Wayne | SVP and CFO | Dec 31, 2020 | Option Exercise | $5.23 | 1,498 | 7,835 | 103,449 | Jan 05, 2021, 08:04 PM |
| Ketchum Steven B | Chief Scientific Officer | Dec 31, 2020 | Option Exercise | $5.23 | 1,506 | 7,876 | 531,504 | Jan 05, 2021, 08:03 PM |
| Kennedy Joseph T | General Counsel | Dec 31, 2020 | Option Exercise | $5.23 | 1,902 | 9,947 | 214,399 | Jan 05, 2021, 08:03 PM |
| THERO JOHN F | President and CEO | Dec 31, 2020 | Option Exercise | $5.23 | 5,302 | 27,729 | 2,755,340 | Jan 05, 2021, 08:01 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Nov 30, 2020 | Option Exercise | $4.60 | 1,506 | 6,928 | 216,042 | Dec 02, 2020, 08:05 PM |
| STACK DAVID M | Director | Nov 30, 2020 | Buy | $4.86 | 25,000 | 121,518 | 25,000 | Dec 02, 2020, 08:05 PM |
| Kalb Michael Wayne | SVP and CFO | Nov 30, 2020 | Option Exercise | $4.60 | 1,498 | 6,891 | 101,891 | Dec 02, 2020, 08:04 PM |
| Ketchum Steven B | Chief Scientific Officer | Nov 30, 2020 | Option Exercise | $4.60 | 1,506 | 6,928 | 529,954 | Dec 02, 2020, 08:03 PM |
| Kennedy Joseph T | General Counsel | Nov 30, 2020 | Option Exercise | $4.60 | 1,902 | 8,749 | 212,689 | Dec 02, 2020, 08:03 PM |
| THERO JOHN F | President and CEO | Nov 30, 2020 | Option Exercise | $4.60 | 5,302 | 24,389 | 2,747,170 | Dec 02, 2020, 08:02 PM |
| THERO JOHN F | President and CEO | Nov 10, 2020 | Option Exercise | $3.40 | 615,261 | 2,091,887 | 3,306,405 | Nov 12, 2020, 08:01 PM |
| THERO JOHN F | President and CEO | Nov 09, 2020 | Option Exercise | $3.40 | 134,739 | 458,113 | 2,691,144 | Nov 12, 2020, 08:01 PM |
| THERO JOHN F | President and CEO | Nov 11, 2020 | Sale | $4.07 | 413,565 | 1,681,183 | 2,739,000 | Nov 12, 2020, 08:01 PM |
| THERO JOHN F | President and CEO | Nov 10, 2020 | Sale | $4.13 | 153,840 | 635,975 | 3,152,565 | Nov 12, 2020, 08:01 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Oct 30, 2020 | Option Exercise | $4.86 | 1,506 | 7,319 | 214,492 | Nov 03, 2020, 08:28 PM |
| Kalb Michael Wayne | SVP and CFO | Oct 30, 2020 | Option Exercise | $4.86 | 1,498 | 7,280 | 98,471 | Nov 03, 2020, 08:27 PM |
| Ketchum Steven B | Chief Scientific Officer | Oct 30, 2020 | Option Exercise | $4.86 | 1,506 | 7,319 | 528,404 | Nov 03, 2020, 08:26 PM |
| Kennedy Joseph T | General Counsel | Oct 30, 2020 | Option Exercise | $4.86 | 1,902 | 9,244 | 210,979 | Nov 03, 2020, 08:25 PM |
| Zakrzewski Joseph S | Director | Oct 21, 2020 | Option Exercise | $3.40 | 100,000 | 340,000 | 184,547 | Oct 22, 2020, 08:03 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Sep 30, 2020 | Option Exercise | $4.04 | 1,506 | 6,084 | 212,942 | Oct 02, 2020, 08:05 PM |
| Ketchum Steven B | Chief Scientific Officer | Sep 30, 2020 | Option Exercise | $4.04 | 1,506 | 6,084 | 526,854 | Oct 02, 2020, 08:04 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Aug 31, 2020 | Option Exercise | $7.36 | 1,506 | 11,084 | 211,392 | Sep 02, 2020, 08:07 PM |
| Kalb Michael Wayne | SVP and CFO | Aug 31, 2020 | Option Exercise | $7.36 | 1,496 | 11,011 | 93,857 | Sep 02, 2020, 08:06 PM |
| Ketchum Steven B | Chief Scientific Officer | Aug 31, 2020 | Option Exercise | $7.36 | 1,506 | 11,084 | 525,304 | Sep 02, 2020, 08:04 PM |
| Kennedy Joseph T | General Counsel | Aug 31, 2020 | Option Exercise | $7.36 | 1,902 | 13,999 | 205,657 | Sep 02, 2020, 08:02 PM |
| THERO JOHN F | President and CEO | Aug 31, 2020 | Option Exercise | $7.36 | 5,302 | 39,023 | 2,529,459 | Sep 02, 2020, 08:01 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jul 31, 2020 | Option Exercise | $6.59 | 1,508 | 9,938 | 209,844 | Jul 31, 2020, 08:07 PM |
| Kalb Michael Wayne | SVP and CFO | Jul 31, 2020 | Option Exercise | $6.59 | 1,498 | 9,872 | 92,299 | Jul 31, 2020, 08:06 PM |
| Ketchum Steven B | Chief Scientific Officer | Jul 31, 2020 | Option Exercise | $6.59 | 1,508 | 9,938 | 523,756 | Jul 31, 2020, 08:05 PM |
| Kennedy Joseph T | General Counsel | Jul 31, 2020 | Option Exercise | $6.59 | 1,904 | 12,547 | 203,949 | Jul 31, 2020, 08:04 PM |
| THERO JOHN F | President and CEO | Jul 31, 2020 | Option Exercise | $6.59 | 5,304 | 34,953 | 2,521,289 | Jul 31, 2020, 08:03 PM |
| THERO JOHN F | President and CEO | Jun 30, 2020 | Option Exercise | $6.72 | 5,302 | 35,629 | 2,513,121 | Jul 02, 2020, 08:38 PM |
| Kennedy Joseph T | General Counsel | Jun 30, 2020 | Option Exercise | $6.72 | 1,902 | 12,781 | 202,243 | Jul 02, 2020, 08:38 PM |
| Ketchum Steven B | Chief Scientific Officer | Jun 30, 2020 | Option Exercise | $6.72 | 1,506 | 10,120 | 522,210 | Jul 02, 2020, 08:37 PM |
| Kalb Michael Wayne | SVP and CFO | Jun 30, 2020 | Option Exercise | $6.72 | 1,496 | 10,053 | 90,743 | Jul 02, 2020, 08:35 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jun 30, 2020 | Option Exercise | $6.72 | 1,506 | 10,120 | 208,298 | Jul 02, 2020, 08:34 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | May 29, 2020 | Option Exercise | $6.86 | 1,506 | 10,331 | 206,750 | Jun 02, 2020, 08:09 PM |
| Kalb Michael Wayne | SVP and CFO | May 29, 2020 | Option Exercise | $6.86 | 1,498 | 10,276 | 89,185 | Jun 02, 2020, 08:08 PM |
| Ketchum Steven B | Chief Scientific Officer | May 29, 2020 | Option Exercise | $6.86 | 1,506 | 10,331 | 520,662 | Jun 02, 2020, 08:08 PM |
| Kennedy Joseph T | General Counsel | May 29, 2020 | Option Exercise | $6.86 | 1,902 | 13,048 | 200,535 | Jun 02, 2020, 08:07 PM |
| THERO JOHN F | President and CEO | May 29, 2020 | Option Exercise | $6.86 | 5,302 | 36,372 | 2,504,951 | Jun 02, 2020, 08:06 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Apr 30, 2020 | Option Exercise | $8.26 | 1,506 | 12,440 | 192,005 | May 01, 2020, 08:12 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | May 01, 2020 | Option Exercise | $7.61 | 12,805 | 97,446 | 205,200 | May 01, 2020, 08:12 PM |
| Kalb Michael Wayne | SVP and CFO | Apr 30, 2020 | Option Exercise | $8.26 | 1,498 | 12,373 | 87,043 | May 01, 2020, 08:10 PM |
| Ketchum Steven B | Chief Scientific Officer | Apr 30, 2020 | Option Exercise | $8.26 | 1,506 | 12,440 | 519,112 | May 01, 2020, 08:10 PM |
| Kennedy Joseph T | General Counsel | Apr 30, 2020 | Option Exercise | $8.26 | 1,902 | 15,711 | 198,827 | May 01, 2020, 08:09 PM |
| THERO JOHN F | President and CEO | Apr 30, 2020 | Option Exercise | $8.26 | 5,302 | 43,795 | 2,496,781 | May 01, 2020, 08:08 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Mar 31, 2020 | Option Exercise | $13.58 | 1,506 | 20,451 | 190,455 | Apr 02, 2020, 08:14 PM |
| Kalb Michael Wayne | SVP and CFO | Mar 31, 2020 | Option Exercise | $13.58 | 1,498 | 20,343 | 85,485 | Apr 02, 2020, 08:14 PM |
| Ketchum Steven B | Chief Scientific Officer | Mar 31, 2020 | Option Exercise | $13.58 | 1,506 | 20,451 | 517,562 | Apr 02, 2020, 08:13 PM |
| THERO JOHN F | President and CEO | Mar 31, 2020 | Option Exercise | $13.58 | 5,302 | 72,001 | 2,488,611 | Apr 02, 2020, 08:12 PM |
| THERO JOHN F | President and CEO | Mar 04, 2020 | Sale | $15.99 | 200,000 | 3,198,700 | 2,480,441 | Mar 06, 2020, 08:03 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Feb 28, 2020 | Option Exercise | $14.67 | 1,506 | 22,093 | 188,905 | Mar 03, 2020, 08:05 PM |
| Kalb Michael Wayne | SVP and CFO | Feb 28, 2020 | Option Exercise | $14.67 | 1,498 | 21,976 | 83,927 | Mar 03, 2020, 08:04 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 28, 2020 | Option Exercise | $14.67 | 1,506 | 22,093 | 516,012 | Mar 03, 2020, 08:04 PM |
| THERO JOHN F | President and CEO | Feb 28, 2020 | Option Exercise | $14.67 | 5,302 | 77,780 | 2,680,441 | Mar 03, 2020, 08:02 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Feb 25, 2020 | Option Exercise | $17.58 | 25,586 | 449,802 | 187,355 | Feb 27, 2020, 08:03 PM |
| Kalb Michael Wayne | SVP and CFO | Feb 25, 2020 | Option Exercise | $17.58 | 25,440 | 447,235 | 82,369 | Feb 27, 2020, 08:03 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 25, 2020 | Option Exercise | $17.58 | 25,586 | 449,802 | 514,462 | Feb 27, 2020, 08:03 PM |
| Kennedy Joseph T | General Counsel | Feb 25, 2020 | Option Exercise | $17.58 | 32,324 | 568,256 | 189,895 | Feb 27, 2020, 08:03 PM |
| THERO JOHN F | President and CEO | Feb 25, 2020 | Option Exercise | $17.58 | 90,124 | 1,584,380 | 2,672,271 | Feb 27, 2020, 08:02 PM |
| THERO JOHN F | President and CEO | Jan 31, 2020 | Option Exercise | $19.04 | 124,287 | 2,366,425 | 2,533,365 | Feb 04, 2020, 08:02 PM |
| Kennedy Joseph T | General Counsel | Jan 31, 2020 | Option Exercise | $19.04 | 39,632 | 754,593 | 160,825 | Feb 04, 2020, 08:02 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2020 | Option Exercise | $19.04 | 33,603 | 639,801 | 488,100 | Feb 04, 2020, 08:02 PM |
| Kalb Michael Wayne | SVP and CFO | Jan 31, 2020 | Option Exercise | $19.04 | 33,425 | 636,412 | 55,861 | Feb 04, 2020, 08:02 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jan 31, 2020 | Option Exercise | $19.04 | 14,547 | 276,975 | 160,993 | Feb 04, 2020, 08:02 PM |
| Zakrzewski Joseph S | Director | Jan 03, 2020 | Option Exercise | $3.40 | 300,000 | 1,020,000 | 384,547 | Jan 03, 2020, 09:30 PM |
| Zakrzewski Joseph S | Director | Jan 03, 2020 | Sale | $20.94 | 300,000 | 6,282,870 | 84,547 | Jan 03, 2020, 09:30 PM |
| Zakrzewski Joseph S | Director | Dec 16, 2019 | Option Exercise | $9.00 | 100,000 | 900,000 | 184,547 | Dec 18, 2019, 08:05 PM |
| Zakrzewski Joseph S | Director | Dec 16, 2019 | Sale | $25.83 | 100,000 | 2,583,380 | 84,547 | Dec 18, 2019, 08:05 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Dec 16, 2019 | Option Exercise | $12.60 | 43,253 | 544,988 | 177,059 | Dec 18, 2019, 08:05 PM |
| Kalb Michael Wayne | SVP and CFO | Dec 16, 2019 | Option Exercise | $2.19 | 25,000 | 54,750 | 46,552 | Dec 18, 2019, 08:05 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Dec 16, 2019 | Sale | $25.46 | 43,253 | 1,101,364 | 133,806 | Dec 18, 2019, 08:05 PM |
| Kalb Michael Wayne | SVP and CFO | Dec 16, 2019 | Sale | $23.36 | 25,000 | 584,012 | 30,152 | Dec 18, 2019, 08:05 PM |
| THERO JOHN F | President and CEO | Nov 19, 2019 | Sale | $22.65 | 274,454 | 6,217,371 | 2,342,285 | Nov 21, 2019, 08:49 PM |
| Ekman Lars | Director | Nov 12, 2019 | Option Exercise | $14.40 | 38,600 | 555,840 | 38,600 | Nov 13, 2019, 08:05 PM |
| Ekman Lars | Director | Nov 12, 2019 | Sale | $19.35 | 38,600 | 746,759 | 0 | Nov 13, 2019, 08:05 PM |
| THERO JOHN F | President and CEO | Nov 11, 2019 | Sale | $17.12 | 475,546 | 8,143,452 | 2,658,480 | Nov 13, 2019, 08:01 PM |
| Ekman Lars | Director | Nov 05, 2019 | Option Exercise | $14.40 | 6,400 | 92,160 | 6,400 | Nov 07, 2019, 08:05 PM |
| Ekman Lars | Director | Nov 05, 2019 | Sale | $18.00 | 6,400 | 115,230 | 0 | Nov 07, 2019, 08:05 PM |
| THERO JOHN F | President and CEO | Oct 28, 2019 | Option Exercise | $2.50 | 11,601 | 29,003 | 3,092,285 | Oct 30, 2019, 08:10 PM |
| THERO JOHN F | President and CEO | Oct 07, 2019 | Option Exercise | $14.37 | 497,876 | 7,154,478 | 3,080,684 | Oct 09, 2019, 08:04 PM |
| Ketchum Steven B | Chief Scientific Officer | Oct 07, 2019 | Option Exercise | $14.37 | 100,023 | 1,437,330 | 453,969 | Oct 09, 2019, 08:03 PM |
| Kennedy Joseph T | General Counsel | Oct 07, 2019 | Option Exercise | $14.37 | 105,037 | 1,509,382 | 125,723 | Oct 09, 2019, 08:02 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Oct 07, 2019 | Option Exercise | $14.37 | 102,045 | 1,466,387 | 133,806 | Oct 09, 2019, 08:01 PM |
| Ekman Lars | Director | Sep 03, 2019 | Option Exercise | $3.52 | 91,016 | 320,280 | 91,016 | Sep 05, 2019, 08:04 PM |
| Ekman Lars | Director | Sep 03, 2019 | Sale | $15.01 | 91,016 | 1,365,722 | 0 | Sep 05, 2019, 08:04 PM |
| THERO JOHN F | President and CEO | Aug 21, 2019 | Option Exercise | $2.50 | 24,999 | 62,498 | 2,313,310 | Aug 23, 2019, 08:19 PM |
| THERO JOHN F | President and CEO | Aug 21, 2019 | Option Exercise | $1.56 | 191,997 | 300,010 | 2,324,911 | Aug 22, 2019, 08:02 PM |
| STACK DAVID M | Director | Jul 11, 2019 | Option Exercise | $2.33 | 51,991 | 121,035 | 51,991 | Jul 12, 2019, 08:03 PM |
| STACK DAVID M | Director | Jul 11, 2019 | Sale | $22.28 | 51,991 | 1,158,354 | 0 | Jul 12, 2019, 08:03 PM |
| Zakrzewski Joseph S | Director | Jul 05, 2019 | Option Exercise | $9.00 | 100,000 | 900,000 | 184,547 | Jul 05, 2019, 09:00 PM |
| Zakrzewski Joseph S | Director | Jul 05, 2019 | Sale | $23.82 | 100,000 | 2,381,580 | 84,547 | Jul 05, 2019, 09:00 PM |
| Kennedy Joseph T | General Counsel | Jul 01, 2019 | Option Exercise | $2.57 | 27,244 | 69,962 | 85,446 | Jul 03, 2019, 08:01 PM |
| Kennedy Joseph T | General Counsel | Jul 01, 2019 | Sale | $19.52 | 54,186 | 1,057,906 | 31,260 | Jul 03, 2019, 08:01 PM |
| Kalb Michael Wayne | SVP and CFO | Jul 01, 2019 | Option Exercise | $2.19 | 50,000 | 109,500 | 70,840 | Jul 03, 2019, 08:00 PM |
| Kalb Michael Wayne | SVP and CFO | Jul 01, 2019 | Sale | $19.67 | 50,000 | 983,270 | 20,840 | Jul 03, 2019, 08:00 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jul 03, 2019 | Option Exercise | $2.80 | 29,250 | 81,900 | 65,601 | Jul 03, 2019, 08:00 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jul 02, 2019 | Option Exercise | $2.50 | 69,564 | 173,910 | 105,915 | Jul 03, 2019, 08:00 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jul 02, 2019 | Sale | $20.73 | 69,564 | 1,442,141 | 55,915 | Jul 03, 2019, 08:00 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jul 03, 2019 | Sale | $22.64 | 29,250 | 662,238 | 36,351 | Jul 03, 2019, 08:00 PM |
| Kennedy Joseph T | General Counsel | Jun 30, 2019 | Option Exercise | $19.39 | 26,495 | 513,738 | 58,202 | Jul 02, 2019, 08:05 PM |
| THERO JOHN F | President and CEO | Jun 30, 2019 | Option Exercise | $19.39 | 14,757 | 286,138 | 2,132,914 | Jul 02, 2019, 08:05 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jun 24, 2019 | Option Exercise | $2.50 | 100,000 | 250,000 | 149,546 | Jun 26, 2019, 08:09 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | Jun 24, 2019 | Sale | $18.59 | 113,195 | 2,104,521 | 36,351 | Jun 26, 2019, 08:09 PM |
| Zakrzewski Joseph S | Director | Jun 18, 2019 | Option Exercise | $3.40 | 100,000 | 340,000 | 184,547 | Jun 20, 2019, 08:05 PM |
| Zakrzewski Joseph S | Director | Jun 18, 2019 | Sale | $19.02 | 100,000 | 1,902,090 | 84,547 | Jun 20, 2019, 08:05 PM |
| Kennedy Joseph T | General Counsel | May 31, 2019 | Option Exercise | $2.57 | 27,229 | 69,925 | 58,489 | May 31, 2019, 08:04 PM |
| Kennedy Joseph T | General Counsel | May 31, 2019 | Sale | $17.92 | 27,229 | 488,058 | 31,260 | May 31, 2019, 08:04 PM |
| STACK DAVID M | Director | May 29, 2019 | Option Exercise | $3.21 | 33,799 | 108,495 | 33,799 | May 31, 2019, 08:02 PM |
| STACK DAVID M | Director | May 29, 2019 | Sale | $18.45 | 33,799 | 623,534 | 0 | May 31, 2019, 08:02 PM |
| STACK DAVID M | Director | May 17, 2019 | Option Exercise | $3.21 | 13,174 | 42,289 | 13,174 | May 21, 2019, 08:14 PM |
| STACK DAVID M | Director | May 17, 2019 | Sale | $18.00 | 13,174 | 237,139 | 0 | May 21, 2019, 08:14 PM |
| Ketchum Steven B | Chief Scientific Officer | Apr 30, 2019 | Option Exercise | $2.33 | 9,541 | 22,235 | 364,033 | May 02, 2019, 09:05 PM |
| Ketchum Steven B | Chief Scientific Officer | Apr 30, 2019 | Sale | $18.67 | 9,541 | 178,107 | 354,492 | May 02, 2019, 09:05 PM |
| Kennedy Joseph T | General Counsel | Apr 30, 2019 | Option Exercise | $2.57 | 27,230 | 69,927 | 58,490 | May 02, 2019, 09:01 PM |
| Kennedy Joseph T | General Counsel | Apr 30, 2019 | Sale | $18.69 | 27,230 | 508,839 | 31,260 | May 02, 2019, 09:01 PM |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | May 01, 2019 | Option Exercise | $18.70 | 12,805 | 239,454 | 49,546 | May 02, 2019, 08:02 PM |
| THERO JOHN F | President and CEO | Mar 31, 2019 | Option Exercise | $20.76 | 14,757 | 306,355 | 2,110,171 | Apr 01, 2019, 08:24 PM |
| Ketchum Steven B | Chief Scientific Officer | Apr 01, 2019 | Option Exercise | $2.33 | 9,542 | 22,236 | 364,034 | Apr 01, 2019, 08:22 PM |
| Ketchum Steven B | Chief Scientific Officer | Apr 01, 2019 | Sale | $20.06 | 9,542 | 191,392 | 354,592 | Apr 01, 2019, 08:22 PM |
| Kennedy Joseph T | General Counsel | Mar 31, 2019 | Option Exercise | $20.76 | 26,495 | 550,036 | 58,202 | Apr 01, 2019, 08:20 PM |
| Kennedy Joseph T | General Counsel | Apr 01, 2019 | Option Exercise | $2.57 | 27,230 | 69,926 | 85,432 | Apr 01, 2019, 08:20 PM |
| Kennedy Joseph T | General Counsel | Apr 01, 2019 | Sale | $20.05 | 54,172 | 1,086,122 | 32,372 | Apr 01, 2019, 08:20 PM |
| THERO JOHN F | President and CEO | Mar 04, 2019 | Sale | $21.31 | 250,000 | 5,327,234 | 2,158,101 | Mar 06, 2019, 08:16 PM |
| Ekman Lars | Director | Mar 04, 2019 | Option Exercise | $2.04 | 135,377 | 276,743 | 135,377 | Mar 06, 2019, 08:16 PM |
| Ekman Lars | Director | Mar 04, 2019 | Sale | $21.31 | 135,377 | 2,884,905 | 36,700 | Mar 06, 2019, 08:16 PM |
| Ketchum Steven B | Chief Scientific Officer | Mar 01, 2019 | Option Exercise | $2.50 | 46,000 | 115,000 | 400,492 | Mar 01, 2019, 08:19 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 28, 2019 | Option Exercise | $2.33 | 9,543 | 22,239 | 364,035 | Mar 01, 2019, 08:19 PM |
| Ketchum Steven B | Chief Scientific Officer | Mar 01, 2019 | Sale | $22.09 | 46,000 | 1,016,275 | 396,989 | Mar 01, 2019, 08:19 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 28, 2019 | Sale | $20.67 | 9,543 | 197,249 | 354,492 | Mar 01, 2019, 08:19 PM |
| Kalb Michael Wayne | SVP and CFO | Mar 01, 2019 | Option Exercise | $2.83 | 100,000 | 283,350 | 120,551 | Mar 01, 2019, 08:18 PM |
| Kalb Michael Wayne | SVP and CFO | Mar 01, 2019 | Sale | $22.09 | 100,000 | 2,209,098 | 113,427 | Mar 01, 2019, 08:18 PM |
| Kennedy Joseph T | General Counsel | Feb 28, 2019 | Option Exercise | $2.57 | 27,231 | 69,928 | 58,491 | Mar 01, 2019, 08:17 PM |
| Kennedy Joseph T | General Counsel | Feb 28, 2019 | Sale | $20.72 | 27,231 | 564,172 | 31,260 | Mar 01, 2019, 08:17 PM |
| Zakrzewski Joseph S | Director | Feb 22, 2019 | Option Exercise | $8.70 | 180,625 | 1,572,312 | 265,172 | Feb 22, 2019, 09:34 PM |
| Zakrzewski Joseph S | Director | Feb 22, 2019 | Sale | $19.90 | 180,625 | 3,594,437 | 84,547 | Feb 22, 2019, 09:34 PM |
| VAN HEEK G JAN | Director | Feb 22, 2019 | Option Exercise | $4.46 | 192,347 | 857,170 | 217,550 | Feb 22, 2019, 09:33 PM |
| VAN HEEK G JAN | Director | Feb 22, 2019 | Sale | $20.02 | 203,382 | 4,071,423 | 14,168 | Feb 22, 2019, 09:33 PM |
| Peterson Kristine | Director | Feb 22, 2019 | Option Exercise | $5.80 | 163,500 | 947,730 | 163,500 | Feb 22, 2019, 09:32 PM |
| Peterson Kristine | Director | Feb 22, 2019 | Sale | $20.02 | 163,500 | 3,274,038 | 0 | Feb 22, 2019, 09:32 PM |
| Kalb Michael Wayne | SVP and CFO | Feb 22, 2019 | Option Exercise | $2.95 | 50,000 | 147,500 | 70,551 | Feb 22, 2019, 09:31 PM |
| Kalb Michael Wayne | SVP and CFO | Feb 22, 2019 | Sale | $18.97 | 50,000 | 948,500 | 20,551 | Feb 22, 2019, 09:31 PM |
| Kalb Michael Wayne | SVP and CFO | Feb 15, 2019 | Sale | $17.58 | 25,000 | 439,525 | 20,551 | Feb 15, 2019, 08:16 PM |
| THERO JOHN F | President and CEO | Jan 31, 2019 | Option Exercise | $16.94 | 143,177 | 2,425,418 | 2,337,428 | Feb 01, 2019, 08:35 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2019 | Option Exercise | $16.94 | 40,482 | 685,765 | 382,481 | Feb 01, 2019, 08:35 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2019 | Option Exercise | $2.33 | 9,541 | 22,235 | 350,838 | Feb 01, 2019, 08:35 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2019 | Sale | $17.49 | 9,541 | 166,875 | 341,297 | Feb 01, 2019, 08:35 PM |
| Ketchum Steven B | Chief Scientific Officer | Feb 01, 2019 | Sale | $17.06 | 27,989 | 477,498 | 354,492 | Feb 01, 2019, 08:35 PM |
| Kennedy Joseph T | General Counsel | Jan 31, 2019 | Option Exercise | $16.94 | 43,962 | 744,716 | 73,884 | Feb 01, 2019, 08:34 PM |
| Kennedy Joseph T | General Counsel | Jan 31, 2019 | Option Exercise | $2.46 | 29,180 | 71,910 | 29,180 | Feb 01, 2019, 08:34 PM |
| Kennedy Joseph T | General Counsel | Jan 31, 2019 | Sale | $17.49 | 42,624 | 745,468 | 31,260 | Feb 01, 2019, 08:34 PM |
| Kalb Michael Wayne | SVP and CFO | Jan 31, 2019 | Option Exercise | $16.94 | 26,935 | 456,279 | 45,551 | Feb 01, 2019, 08:33 PM |
| Kennedy Joseph T | General Counsel | Jan 24, 2019 | Option Exercise | $6.06 | 391,181 | 2,370,612 | 609,115 | Jan 24, 2019, 08:20 PM |
| Kennedy Joseph T | General Counsel | Jan 23, 2019 | Option Exercise | $7.19 | 255,779 | 1,840,134 | 473,713 | Jan 24, 2019, 08:20 PM |
| Kennedy Joseph T | General Counsel | Jan 22, 2019 | Option Exercise | $4.59 | 175,300 | 804,656 | 393,234 | Jan 24, 2019, 08:20 PM |
| Kennedy Joseph T | General Counsel | Jan 24, 2019 | Sale | $17.66 | 609,115 | 10,754,717 | 0 | Jan 24, 2019, 08:20 PM |
| Kennedy Joseph T | General Counsel | Jan 23, 2019 | Sale | $17.95 | 255,779 | 4,591,310 | 217,934 | Jan 24, 2019, 08:20 PM |
| Kennedy Joseph T | General Counsel | Jan 22, 2019 | Sale | $17.92 | 175,300 | 3,141,884 | 217,934 | Jan 24, 2019, 08:20 PM |
| Zakrzewski Joseph S | Director | Jan 10, 2019 | Option Exercise | $3.40 | 200,000 | 680,000 | 284,547 | Jan 11, 2019, 08:18 PM |
| Zakrzewski Joseph S | Director | Jan 10, 2019 | Sale | $16.98 | 200,000 | 3,396,390 | 184,547 | Jan 11, 2019, 08:18 PM |
| STACK DAVID M | Director | Jan 10, 2019 | Option Exercise | $5.86 | 98,572 | 577,855 | 98,572 | Jan 11, 2019, 08:18 PM |
| STACK DAVID M | Director | Jan 10, 2019 | Option Exercise | $2.94 | 26,932 | 79,172 | 26,932 | Jan 11, 2019, 08:18 PM |
| STACK DAVID M | Director | Jan 10, 2019 | Sale | $18.00 | 98,572 | 1,774,296 | 0 | Jan 11, 2019, 08:18 PM |
| STACK DAVID M | Director | Jan 10, 2019 | Sale | $18.00 | 26,932 | 484,776 | 0 | Jan 11, 2019, 08:18 PM |
| Kennedy Joseph T | General Counsel | Jan 11, 2019 | Option Exercise | $2.95 | 3,173 | 9,360 | 221,107 | Jan 11, 2019, 08:17 PM |
| Kennedy Joseph T | General Counsel | Jan 11, 2019 | Sale | $18.92 | 3,173 | 60,033 | 217,934 | Jan 11, 2019, 08:17 PM |
| Kalb Michael Wayne | SVP and CFO | Jan 09, 2019 | Option Exercise | $2.19 | 200,000 | 438,000 | 217,486 | Jan 11, 2019, 08:16 PM |
| Kalb Michael Wayne | SVP and CFO | Jan 09, 2019 | Sale | $15.26 | 200,000 | 3,051,080 | 17,486 | Jan 11, 2019, 08:16 PM |
| Ekman Lars | Director | Jan 10, 2019 | Option Exercise | $1.03 | 100,416 | 103,428 | 140,416 | Jan 11, 2019, 08:16 PM |
| Ekman Lars | Director | Jan 10, 2019 | Sale | $17.28 | 140,416 | 2,426,489 | 119,216 | Jan 11, 2019, 08:16 PM |
| Zakrzewski Joseph S | Director | Jan 02, 2019 | Option Exercise | $3.21 | 385,000 | 1,237,250 | 469,547 | Jan 02, 2019, 07:54 PM |
| Zakrzewski Joseph S | Director | Jan 02, 2019 | Sale | $13.03 | 385,000 | 5,015,703 | 84,547 | Jan 02, 2019, 07:54 PM |
| Zakrzewski Joseph S | Director | Dec 28, 2018 | Sale | $13.19 | 141,500 | 1,866,668 | 84,547 | Jan 02, 2019, 07:54 PM |
| Kennedy Joseph T | General Counsel | Dec 31, 2018 | Option Exercise | $13.24 | 26,495 | 350,794 | 244,877 | Jan 02, 2019, 07:53 PM |
| Kennedy Joseph T | General Counsel | Dec 31, 2018 | Sale | $13.49 | 26,943 | 363,547 | 217,934 | Jan 02, 2019, 07:53 PM |
| Ketchum Steven B | Chief Scientific Officer | Dec 31, 2018 | Option Exercise | $2.41 | 17,041 | 40,985 | 358,338 | Jan 02, 2019, 07:51 PM |
| Ketchum Steven B | Chief Scientific Officer | Dec 31, 2018 | Sale | $13.51 | 17,041 | 230,212 | 341,297 | Jan 02, 2019, 07:51 PM |
| THERO JOHN F | President and CEO | Dec 31, 2018 | Option Exercise | $13.24 | 14,757 | 195,383 | 2,117,271 | Jan 02, 2019, 07:45 PM |
| Ketchum Steven B | Chief Scientific Officer | Nov 30, 2018 | Option Exercise | $2.41 | 17,042 | 40,988 | 358,339 | Nov 30, 2018, 06:34 PM |
| Ketchum Steven B | Chief Scientific Officer | Nov 30, 2018 | Sale | $17.79 | 17,042 | 303,174 | 341,297 | Nov 30, 2018, 06:34 PM |
| Kennedy Joseph T | General Counsel | Nov 30, 2018 | Option Exercise | $2.25 | 23,306 | 52,510 | 241,240 | Nov 30, 2018, 06:33 PM |
| Kennedy Joseph T | General Counsel | Nov 30, 2018 | Sale | $17.81 | 23,306 | 414,998 | 217,934 | Nov 30, 2018, 06:33 PM |
| THERO JOHN F | President and CEO | Nov 12, 2018 | Option Exercise | $1.35 | 407,611 | 550,275 | 2,702,139 | Nov 14, 2018, 06:02 PM |
| THERO JOHN F | President and CEO | Nov 12, 2018 | Sale | $19.07 | 607,611 | 11,587,896 | 2,565,717 | Nov 14, 2018, 06:02 PM |
| Ketchum Steven B | Chief Scientific Officer | Oct 31, 2018 | Option Exercise | $2.41 | 17,042 | 40,988 | 358,339 | Nov 02, 2018, 06:11 PM |
| Ketchum Steven B | Chief Scientific Officer | Oct 31, 2018 | Sale | $20.74 | 17,042 | 353,454 | 341,797 | Nov 02, 2018, 06:11 PM |
| Kennedy Joseph T | General Counsel | Oct 31, 2018 | Option Exercise | $2.25 | 23,307 | 52,513 | 241,241 | Nov 02, 2018, 06:10 PM |
| Kennedy Joseph T | General Counsel | Oct 31, 2018 | Sale | $20.74 | 23,307 | 483,362 | 218,534 | Nov 02, 2018, 06:10 PM |
| THERO JOHN F | President and CEO | Sep 30, 2018 | Option Exercise | $16.27 | 14,757 | 240,096 | 2,294,528 | Oct 02, 2018, 07:11 PM |
| Ketchum Steven B | Chief Scientific Officer | Oct 01, 2018 | Option Exercise | $7.86 | 116,604 | 916,893 | 457,901 | Oct 02, 2018, 07:05 PM |
| Ketchum Steven B | Chief Scientific Officer | Sep 28, 2018 | Option Exercise | $8.77 | 200,000 | 1,754,000 | 541,297 | Oct 02, 2018, 07:05 PM |
| Ketchum Steven B | Chief Scientific Officer | Sep 28, 2018 | Sale | $15.50 | 200,000 | 3,100,000 | 441,297 | Oct 02, 2018, 07:05 PM |
| Ketchum Steven B | Chief Scientific Officer | Oct 01, 2018 | Sale | $17.20 | 116,604 | 2,005,589 | 341,297 | Oct 02, 2018, 07:05 PM |
| Kennedy Joseph T | General Counsel | Sep 30, 2018 | Option Exercise | $16.27 | 26,495 | 431,074 | 244,877 | Oct 02, 2018, 07:02 PM |
| Kennedy Joseph T | General Counsel | Oct 01, 2018 | Option Exercise | $2.25 | 23,306 | 52,510 | 268,183 | Oct 02, 2018, 07:02 PM |
| Kennedy Joseph T | General Counsel | Oct 01, 2018 | Sale | $16.81 | 50,249 | 844,528 | 235,134 | Oct 02, 2018, 07:02 PM |
| Zakrzewski Joseph S | Director | Sep 24, 2018 | Option Exercise | $3.40 | 500,000 | 1,700,000 | 726,047 | Sep 26, 2018, 08:54 PM |
| Zakrzewski Joseph S | Director | Sep 24, 2018 | Sale | $10.60 | 500,000 | 5,299,334 | 318,796 | Sep 26, 2018, 08:54 PM |
| Ketchum Steven B | Chief Scientific Officer | Sep 25, 2018 | Option Exercise | $8.77 | 200,000 | 1,754,000 | 541,297 | Sep 26, 2018, 08:52 PM |
| Ketchum Steven B | Chief Scientific Officer | Sep 24, 2018 | Option Exercise | $3.82 | 620,065 | 2,366,711 | 1,020,538 | Sep 26, 2018, 08:52 PM |
| Ketchum Steven B | Chief Scientific Officer | Sep 25, 2018 | Sale | $13.50 | 200,000 | 2,700,000 | 441,297 | Sep 26, 2018, 08:52 PM |
| Ketchum Steven B | Chief Scientific Officer | Sep 24, 2018 | Sale | $10.39 | 679,241 | 7,060,024 | 490,747 | Sep 26, 2018, 08:52 PM |
| Kennedy Joseph T | General Counsel | Sep 24, 2018 | Option Exercise | $2.22 | 1,079,706 | 2,393,014 | 1,297,640 | Sep 26, 2018, 08:50 PM |
| Kennedy Joseph T | General Counsel | Sep 24, 2018 | Sale | $10.56 | 1,079,706 | 11,400,975 | 412,840 | Sep 26, 2018, 08:50 PM |
| Kalb Michael Wayne | SVP and CFO | Sep 24, 2018 | Option Exercise | $2.19 | 150,000 | 328,500 | 164,996 | Sep 26, 2018, 08:47 PM |
| Kalb Michael Wayne | SVP and CFO | Sep 24, 2018 | Sale | $10.42 | 150,000 | 1,562,751 | 85,196 | Sep 26, 2018, 08:47 PM |
| THERO JOHN F | President and CEO | Sep 22, 2018 | Option Exercise | $2.99 | 497,876 | 1,488,649 | 2,271,785 | Sep 25, 2018, 06:35 PM |
| THERO JOHN F | President and CEO | Jun 30, 2018 | Option Exercise | $3.09 | 14,757 | 45,599 | 1,504,411 | Jul 03, 2018, 12:00 AM |
| Kennedy Joseph T | General Counsel | Jun 30, 2018 | Option Exercise | $3.09 | 26,495 | 81,870 | 45,376 | Jul 03, 2018, 12:00 AM |
| Kennedy Joseph T | General Counsel | Jul 02, 2018 | Sale | $3.00 | 26,942 | 80,955 | 18,434 | Jul 03, 2018, 12:00 AM |
| THERO JOHN F | President and CEO | Mar 31, 2018 | Option Exercise | $3.01 | 14,757 | 44,419 | 1,481,668 | Apr 03, 2018, 08:12 PM |
| Kennedy Joseph T | General Counsel | Mar 31, 2018 | Option Exercise | $3.01 | 26,495 | 79,750 | 45,376 | Apr 03, 2018, 08:12 PM |
| Kennedy Joseph T | General Counsel | Apr 03, 2018 | Sale | $2.89 | 19,042 | 55,052 | 18,434 | Apr 03, 2018, 08:12 PM |
| Kennedy Joseph T | General Counsel | Apr 02, 2018 | Sale | $2.91 | 7,900 | 23,020 | 37,476 | Apr 03, 2018, 08:12 PM |
| THERO JOHN F | President and CEO | Jan 31, 2018 | Option Exercise | $3.83 | 197,513 | 756,475 | 1,458,925 | Feb 02, 2018, 08:28 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2018 | Option Exercise | $3.83 | 57,428 | 219,949 | 200,973 | Feb 02, 2018, 08:26 PM |
| Kennedy Joseph T | General Counsel | Jan 31, 2018 | Option Exercise | $3.83 | 60,313 | 230,999 | 63,291 | Feb 02, 2018, 08:25 PM |
| Kennedy Joseph T | General Counsel | Jan 31, 2018 | Sale | $3.73 | 44,857 | 167,388 | 18,434 | Feb 02, 2018, 08:25 PM |
| Kalb Michael Wayne | SVP and CFO | Jan 31, 2018 | Option Exercise | $3.83 | 14,004 | 53,635 | 14,996 | Feb 02, 2018, 08:24 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 23, 2018 | Option Exercise | $2.04 | 135,205 | 275,818 | 277,002 | Jan 23, 2018, 06:00 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 23, 2018 | Sale | $4.41 | 135,205 | 596,430 | 141,797 | Jan 23, 2018, 06:00 PM |
| Kennedy Joseph T | General Counsel | Jan 16, 2018 | Sale | $4.13 | 10,000 | 41,300 | 31,519 | Jan 17, 2018, 05:58 PM |
| Kennedy Joseph T | General Counsel | Jan 12, 2018 | Sale | $4.29 | 9,587 | 41,128 | 41,519 | Jan 17, 2018, 05:58 PM |
| Kennedy Joseph T | General Counsel | Jan 17, 2018 | Sale | $4.03 | 31,519 | 127,022 | 0 | Jan 17, 2018, 05:58 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 11, 2018 | Option Exercise | $2.04 | 2,612 | 5,328 | 144,409 | Jan 16, 2018, 06:00 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 11, 2018 | Sale | $4.40 | 2,612 | 11,493 | 141,797 | Jan 16, 2018, 06:00 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 05, 2018 | Option Exercise | $2.04 | 64,683 | 131,953 | 206,480 | Jan 09, 2018, 06:00 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 05, 2018 | Sale | $4.40 | 64,683 | 284,631 | 141,797 | Jan 09, 2018, 06:00 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 02, 2018 | Option Exercise | $1.20 | 128,257 | 153,583 | 270,054 | Jan 04, 2018, 07:40 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 02, 2018 | Sale | $4.25 | 128,257 | 545,092 | 141,797 | Jan 04, 2018, 07:40 PM |
| THERO JOHN F | President and CEO | Dec 31, 2017 | Option Exercise | $4.01 | 15,732 | 63,085 | 1,156,771 | Jan 02, 2018, 04:32 PM |
| Kennedy Joseph T | General Counsel | Dec 31, 2017 | Option Exercise | $4.01 | 27,885 | 111,819 | 51,106 | Jan 02, 2018, 04:32 PM |
| THERO JOHN F | President and CEO | Nov 30, 2017 | Buy | $3.24 | 10,000 | 32,446 | 1,135,003 | Dec 04, 2017, 09:02 AM |
| Ketchum Steven B | Chief Scientific Officer | Oct 05, 2017 | Sale | $3.48 | 63,479 | 221,199 | 141,797 | Oct 06, 2017, 07:22 PM |
| THERO JOHN F | President and CEO | Sep 30, 2017 | Option Exercise | $3.50 | 15,732 | 55,062 | 1,125,003 | Oct 03, 2017, 04:24 PM |
| Kennedy Joseph T | General Counsel | Sep 30, 2017 | Option Exercise | $3.50 | 27,885 | 97,598 | 25,553 | Oct 03, 2017, 04:24 PM |
| THERO JOHN F | President and CEO | Jun 30, 2017 | Option Exercise | $4.03 | 15,732 | 63,400 | 1,103,235 | Jul 03, 2017, 07:21 PM |
| Kennedy Joseph T | General Counsel | Jun 30, 2017 | Option Exercise | $4.03 | 27,885 | 112,377 | 156,143 | Jul 03, 2017, 07:20 PM |
| Kennedy Joseph T | General Counsel | Jul 03, 2017 | Sale | $4.09 | 51,104 | 209,158 | 0 | Jul 03, 2017, 07:20 PM |
| Kennedy Joseph T | General Counsel | Jun 30, 2017 | Sale | $3.98 | 105,039 | 417,950 | 51,104 | Jul 03, 2017, 07:20 PM |
| Kennedy Joseph T | General Counsel | Jun 29, 2017 | Sale | $3.98 | 151,768 | 603,824 | 130,591 | Jul 03, 2017, 07:20 PM |
| Kennedy Joseph T | General Counsel | Mar 31, 2017 | Option Exercise | $3.20 | 26,981 | 86,339 | 282,359 | Apr 03, 2017, 05:01 PM |
| THERO JOHN F | President and CEO | Mar 31, 2017 | Option Exercise | $3.20 | 15,732 | 50,342 | 1,081,467 | Apr 03, 2017, 05:00 PM |
| THERO JOHN F | President and CEO | Jan 31, 2017 | Option Exercise | $2.97 | 231,718 | 688,202 | 1,059,699 | Feb 02, 2017, 05:07 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2017 | Option Exercise | $2.97 | 70,236 | 208,601 | 205,276 | Feb 02, 2017, 05:06 PM |
| Kennedy Joseph T | General Counsel | Jan 31, 2017 | Option Exercise | $2.97 | 75,875 | 225,349 | 255,903 | Feb 02, 2017, 05:04 PM |
| Kennedy Joseph T | General Counsel | Dec 31, 2016 | Option Exercise | $3.08 | 27,885 | 85,886 | 187,673 | Jan 03, 2017, 04:31 PM |
| THERO JOHN F | President and CEO | Dec 31, 2016 | Option Exercise | $3.08 | 20,194 | 62,198 | 741,917 | Jan 03, 2017, 04:30 PM |
| Kennedy Joseph T | General Counsel | Nov 09, 2016 | Sale | $3.04 | 122,358 | 372,042 | 162,120 | Nov 10, 2016, 05:00 PM |
| Kennedy Joseph T | General Counsel | Sep 30, 2016 | Option Exercise | $3.19 | 27,885 | 88,953 | 284,478 | Sep 30, 2016, 09:26 PM |
| THERO JOHN F | President and CEO | Sep 30, 2016 | Option Exercise | $3.19 | 20,194 | 64,419 | 724,611 | Sep 30, 2016, 09:25 PM |
| THERO JOHN F | President and CEO | Jun 30, 2016 | Option Exercise | $2.16 | 14,719 | 31,793 | 707,305 | Jul 05, 2016, 07:09 PM |
| Kennedy Joseph T | General Counsel | Jun 30, 2016 | Option Exercise | $2.16 | 27,885 | 60,232 | 258,925 | Jul 05, 2016, 07:08 PM |
| Kennedy Joseph T | General Counsel | Mar 31, 2016 | Option Exercise | $1.53 | 20,082 | 30,725 | 233,373 | Apr 01, 2016, 06:00 PM |
| THERO JOHN F | President and CEO | Mar 31, 2016 | Option Exercise | $1.53 | 14,719 | 22,520 | 684,524 | Apr 01, 2016, 05:58 PM |
| THERO JOHN F | President and CEO | Feb 01, 2016 | Buy | $1.37 | 25,000 | 34,250 | 661,743 | Feb 03, 2016, 08:11 AM |
| THERO JOHN F | President and CEO | Jan 31, 2016 | Option Exercise | $1.36 | 172,157 | 234,134 | 636,743 | Feb 02, 2016, 04:18 PM |
| Ketchum Steven B | Chief Scientific Officer | Jan 31, 2016 | Option Exercise | $1.36 | 42,531 | 57,842 | 131,407 | Feb 02, 2016, 04:17 PM |
| Kennedy Joseph T | General Counsel | Jan 31, 2016 | Option Exercise | $1.36 | 47,581 | 64,710 | 200,018 | Feb 02, 2016, 04:15 PM |
| Farrell Michael James | VP, Finance | Jan 31, 2016 | Option Exercise | $1.36 | 11,597 | 15,772 | 30,190 | Feb 02, 2016, 04:14 PM |
| Kennedy Joseph T | General Counsel | Dec 31, 2015 | Option Exercise | $1.89 | 20,082 | 37,955 | 130,161 | Jan 04, 2016, 05:14 PM |
| Kennedy Joseph T | General Counsel | Oct 05, 2015 | Option Exercise | $2.05 | 2,349 | 4,815 | 96,805 | Oct 06, 2015, 04:31 PM |
| Kennedy Joseph T | General Counsel | Sep 30, 2015 | Option Exercise | $1.93 | 17,734 | 34,227 | 92,904 | Oct 02, 2015, 04:31 PM |
| THERO JOHN F | President and CEO | Aug 11, 2015 | Buy | $2.35 | 20,000 | 47,000 | 304,400 | Aug 11, 2015, 04:30 PM |
| Farrell Michael James | Controller | Nov 11, 2014 | Buy | $0.84 | 5,500 | 4,606 | 6,037 | Nov 12, 2014, 07:59 PM |
| THERO JOHN F | President, Chief Exec. Officer | Nov 11, 2014 | Buy | $0.80 | 30,000 | 24,000 | 94,900 | Nov 12, 2014, 07:59 PM |
| THERO JOHN F | President, Chief Exec. Officer | Nov 12, 2014 | Buy | $0.88 | 20,000 | 17,600 | 114,900 | Nov 12, 2014, 07:59 PM |
| Ekman Lars | Director | Nov 20, 2013 | Buy | $1.80 | 40,000 | 72,000 | 40,000 | Nov 20, 2013, 06:11 PM |
| THERO JOHN F | President | Nov 20, 2013 | Buy | $1.90 | 5,000 | 9,500 | 64,900 | Nov 20, 2013, 04:18 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Nov 18, 2013 | Buy | $1.54 | 50,777 | 78,197 | 226,047 | Nov 18, 2013, 04:15 PM |
| VAN HEEK G JAN | Director | Jul 10, 2013 | Option Exercise | $5.59 | 1,755 | 9,810 | 25,203 | Jul 11, 2013, 06:59 AM |
| Zakrzewski Joseph S | Chief Executive Officer | Jun 25, 2013 | Option Exercise | $1.35 | 10,000 | 13,500 | 141,937 | Jun 25, 2013, 04:05 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Jun 21, 2013 | Option Exercise | $1.35 | 10,000 | 13,500 | 131,937 | Jun 21, 2013, 04:05 PM |
| THERO JOHN F | President | May 29, 2013 | Option Exercise | $1.35 | 11,000 | 14,850 | 50,450 | May 29, 2013, 04:30 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Apr 25, 2013 | Option Exercise | $1.35 | 10,000 | 13,500 | 121,937 | Apr 25, 2013, 04:23 PM |
| VAN HEEK G JAN | Director | Apr 10, 2013 | Option Exercise | $7.38 | 1,329 | 9,808 | 23,448 | Apr 15, 2013, 08:44 AM |
| THERO JOHN F | President | Jan 30, 2013 | Option Exercise | $1.35 | 10,000 | 13,500 | 39,450 | Jan 30, 2013, 05:58 PM |
| VAN HEEK G JAN | Director | Jan 10, 2013 | Option Exercise | $8.37 | 948 | 7,935 | 22,119 | Jan 14, 2013, 07:08 AM |
| VAN HEEK G JAN | Director | Oct 10, 2012 | Option Exercise | $11.20 | 708 | 7,930 | 21,171 | Oct 12, 2012, 08:32 AM |
| Zakrzewski Joseph S | Chief Executive Officer | Oct 01, 2012 | Option Exercise | $1.35 | 150,000 | 202,500 | 261,937 | Oct 03, 2012, 09:50 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Oct 01, 2012 | Sale | $12.56 | 150,000 | 1,884,315 | 111,937 | Oct 03, 2012, 09:50 PM |
| THERO JOHN F | President | Sep 24, 2012 | Option Exercise | $1.35 | 10,000 | 13,500 | 29,450 | Sep 24, 2012, 04:35 PM |
| THERO JOHN F | President | Sep 11, 2012 | Option Exercise | $1.35 | 10,000 | 13,500 | 19,450 | Sep 11, 2012, 06:13 PM |
| HEALY JAMES | Director | Aug 31, 2012 | Option Exercise | $1.03 | 30,000 | 30,900 | 90,000 | Sep 05, 2012, 06:33 PM |
| GORDON CARL L | Director | Sep 04, 2012 | Sale | $14.43 | 233,700 | 3,372,992 | 594,300 | Sep 05, 2012, 05:38 PM |
| ORBIMED ADVISORS LLC | Director | Sep 04, 2012 | Sale | $14.43 | 233,700 | 3,372,992 | 594,300 | Sep 05, 2012, 05:33 PM |
| HEALY JAMES | Director | Aug 14, 2012 | Option Exercise | $1.50 | 808,200 | 1,212,300 | 6,321,588 | Aug 15, 2012, 07:28 PM |
| GORDON CARL L | Director | Jul 27, 2012 | Sale | $14.61 | 366,300 | 5,350,691 | 825,756 | Jul 30, 2012, 07:32 PM |
| ORBIMED ADVISORS LLC | Director | Jul 27, 2012 | Sale | $14.61 | 3,456 | 50,483 | 7,944 | Jul 30, 2012, 07:26 PM |
| ORBIMED ADVISORS LLC | Director | Jul 27, 2012 | Sale | $14.61 | 362,844 | 5,300,207 | 825,756 | Jul 30, 2012, 07:26 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Jul 27, 2012 | Option Exercise | $1.35 | 150,000 | 202,500 | 261,937 | Jul 30, 2012, 06:51 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Jul 27, 2012 | Sale | $14.31 | 150,000 | 2,147,192 | 189,991 | Jul 30, 2012, 06:51 PM |
| THERO JOHN F | President | Jul 27, 2012 | Option Exercise | $2.37 | 300,926 | 713,750 | 160,376 | Jul 30, 2012, 06:50 PM |
| THERO JOHN F | President | Jul 27, 2012 | Sale | $14.34 | 300,926 | 4,315,862 | 9,450 | Jul 30, 2012, 06:50 PM |
| Kennedy Joseph T | Senior VP and General Counsel | Jul 27, 2012 | Sale | $13.85 | 6,950 | 96,290 | 6,409 | Jul 30, 2012, 06:49 PM |
| Huff Paul | Chief Commercial Officer | Jul 27, 2012 | Sale | $13.85 | 6,950 | 96,290 | 6,409 | Jul 30, 2012, 06:48 PM |
| SEDLACK STUART D | Senior Vice President | Jul 27, 2012 | Sale | $13.85 | 6,950 | 96,290 | 6,409 | Jul 30, 2012, 06:46 PM |
| VAN HEEK G JAN | Director | Jul 10, 2012 | Option Exercise | $14.40 | 551 | 7,934 | 20,463 | Jul 12, 2012, 06:36 PM |
| Huff Paul | Chief Commercial Officer | Jun 27, 2012 | Option Exercise | $8.79 | 48,900 | 429,831 | 48,900 | Jun 27, 2012, 05:30 PM |
| Huff Paul | Chief Commercial Officer | Jun 26, 2012 | Option Exercise | $8.79 | 1,100 | 9,669 | 1,100 | Jun 27, 2012, 05:30 PM |
| Huff Paul | Chief Commercial Officer | Jun 27, 2012 | Sale | $15.01 | 48,900 | 734,204 | 0 | Jun 27, 2012, 05:30 PM |
| Huff Paul | Chief Commercial Officer | Jun 26, 2012 | Sale | $13.52 | 1,100 | 14,870 | 0 | Jun 27, 2012, 05:30 PM |
| GORDON CARL L | Director | Jun 19, 2012 | Sale | $12.94 | 617,100 | 7,986,701 | 1,188,600 | Jun 19, 2012, 07:37 PM |
| ORBIMED ADVISORS LLC | Director | Jun 19, 2012 | Sale | $12.91 | 5,900 | 76,185 | 11,400 | Jun 19, 2012, 07:31 PM |
| ORBIMED ADVISORS LLC | Director | Jun 19, 2012 | Sale | $12.91 | 611,200 | 7,892,242 | 1,188,600 | Jun 19, 2012, 07:31 PM |
| Huff Paul | Chief Commercial Officer | Jun 18, 2012 | Option Exercise | $8.79 | 162,925 | 1,432,111 | 162,925 | Jun 19, 2012, 07:03 PM |
| Huff Paul | Chief Commercial Officer | Jun 15, 2012 | Option Exercise | $8.79 | 100 | 879 | 100 | Jun 19, 2012, 07:03 PM |
| Huff Paul | Chief Commercial Officer | Jun 15, 2012 | Sale | $12.00 | 100 | 1,200 | 0 | Jun 19, 2012, 07:03 PM |
| Huff Paul | Chief Commercial Officer | Jun 18, 2012 | Sale | $12.00 | 162,925 | 1,955,524 | 0 | Jun 19, 2012, 07:03 PM |
| Huff Paul | Chief Commercial Officer | Jun 07, 2012 | Option Exercise | $6.64 | 16,725 | 111,008 | 16,725 | Jun 08, 2012, 05:08 PM |
| Huff Paul | Chief Commercial Officer | Jun 07, 2012 | Sale | $12.06 | 16,725 | 201,635 | 0 | Jun 08, 2012, 05:08 PM |
| Zakrzewski Joseph S | Chief Executive Officer | May 29, 2012 | Option Exercise | $1.35 | 150,000 | 202,500 | 228,604 | May 31, 2012, 07:46 PM |
| Zakrzewski Joseph S | Chief Executive Officer | May 29, 2012 | Sale | $11.97 | 150,000 | 1,795,215 | 78,604 | May 31, 2012, 07:46 PM |
| Abingworth LLP | 10% Owner | Apr 19, 2012 | Sale | $9.66 | 682,000 | 6,586,347 | 1,599,168 | Apr 26, 2012, 05:04 PM |
| Abingworth LLP | 10% Owner | Apr 18, 2012 | Sale | $9.60 | 1,614,341 | 15,505,584 | 2,281,168 | Apr 26, 2012, 05:04 PM |
| Abingworth LLP | 10% Owner | Apr 17, 2012 | Sale | $9.61 | 1,712,000 | 16,454,204 | 3,895,509 | Apr 26, 2012, 05:04 PM |
| Abingworth LLP | 10% Owner | Apr 17, 2012 | Sale | $9.61 | 1,712,000 | 16,454,204 | 3,895,509 | Apr 19, 2012, 05:58 PM |
| Abingworth LLP | 10% Owner | Apr 19, 2012 | Sale | $9.66 | 682,000 | 6,586,347 | 1,599,168 | Apr 19, 2012, 05:58 PM |
| Abingworth LLP | 10% Owner | Apr 18, 2012 | Sale | $9.60 | 1,614,341 | 15,505,584 | 2,281,168 | Apr 19, 2012, 05:58 PM |
| VAN HEEK G JAN | Director | Apr 10, 2012 | Option Exercise | $9.35 | 848 | 7,929 | 19,912 | Apr 12, 2012, 07:46 PM |
| THERO JOHN F | President | Apr 09, 2012 | Option Exercise | $1.35 | 150,926 | 203,750 | 150,926 | Apr 11, 2012, 05:57 PM |
| THERO JOHN F | President | Apr 09, 2012 | Sale | $9.96 | 150,926 | 1,503,072 | 0 | Apr 11, 2012, 05:57 PM |
| Abingworth LLP | 10% Owner | Apr 03, 2012 | Sale | $11.00 | 2,300,000 | 25,300,000 | 5,607,509 | Apr 05, 2012, 05:15 PM |
| HEALY JAMES | Director | Apr 03, 2012 | Sale | $10.98 | 1,735,650 | 19,059,665 | 6,513,388 | Apr 04, 2012, 05:00 PM |
| HEALY JAMES | Director | Apr 02, 2012 | Sale | $10.99 | 264,350 | 2,905,286 | 7,249,038 | Apr 04, 2012, 05:00 PM |
| HEALY JAMES | Director | Mar 29, 2012 | Sale | $10.98 | 993,698 | 10,910,804 | 7,513,388 | Mar 30, 2012, 04:15 PM |
| HEALY JAMES | Director | Mar 28, 2012 | Sale | $11.73 | 6,302 | 73,922 | 8,507,086 | Mar 30, 2012, 04:15 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Mar 23, 2012 | Option Exercise | $1.35 | 160,000 | 216,000 | 238,604 | Mar 27, 2012, 07:01 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Mar 23, 2012 | Sale | $11.59 | 160,000 | 1,854,560 | 78,604 | Mar 27, 2012, 07:01 PM |
| HEALY JAMES | Director | Jan 27, 2012 | Option Exercise | $1.03 | 60,000 | 61,800 | 60,000 | Jan 31, 2012, 05:51 PM |
| VAN HEEK G JAN | Director | Jan 10, 2012 | Option Exercise | $7.06 | 894 | 6,312 | 19,064 | Jan 12, 2012, 06:07 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Nov 07, 2011 | Option Exercise | $1.35 | 5,000 | 6,750 | 78,604 | Nov 07, 2011, 04:50 PM |
| VAN HEEK G JAN | Director | Oct 11, 2011 | Option Exercise | $9.47 | 666 | 6,307 | 18,170 | Oct 18, 2011, 06:34 PM |
| Anderson Joseph | Director | Oct 11, 2011 | Option Exercise | $9.47 | 832 | 7,879 | 11,683 | Oct 18, 2011, 06:32 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Aug 22, 2011 | Option Exercise | $1.35 | 5,000 | 6,750 | 73,604 | Aug 22, 2011, 05:01 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Jul 15, 2011 | Option Exercise | $1.35 | 5,000 | 6,750 | 68,604 | Jul 15, 2011, 07:07 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Jul 15, 2011 | Option Exercise | $1.35 | 5,000 | 6,750 | 68,604 | Jul 15, 2011, 05:57 PM |
| VAN HEEK G JAN | Director | Jul 11, 2011 | Option Exercise | $14.18 | 445 | 6,310 | 17,504 | Jul 13, 2011, 05:27 PM |
| Anderson Joseph | Director | Jul 11, 2011 | Option Exercise | $14.18 | 468 | 6,636 | 10,851 | Jul 13, 2011, 05:25 PM |
| Anderson Joseph | Director | Oct 11, 2010 | Option Exercise | $2.95 | 2,165 | 6,387 | 8,908 | May 16, 2011, 09:46 PM |
| Anderson Joseph | Director | Jul 12, 2010 | Option Exercise | $2.28 | 2,801 | 6,386 | 6,743 | May 16, 2011, 09:46 PM |
| Anderson Joseph | Director | Apr 12, 2010 | Option Exercise | $1.62 | 3,942 | 6,386 | 3,942 | May 16, 2011, 09:46 PM |
| Anderson Joseph | Director | Apr 11, 2011 | Option Exercise | $8.50 | 751 | 6,384 | 10,383 | May 16, 2011, 09:46 PM |
| Anderson Joseph | Director | Jan 10, 2011 | Option Exercise | $8.81 | 724 | 6,378 | 9,632 | May 16, 2011, 09:46 PM |
| VAN HEEK G JAN | Director | Apr 11, 2011 | Option Exercise | $8.50 | 742 | 6,307 | 17,059 | May 16, 2011, 09:25 PM |
| ORBIMED ADVISORS LLC | Director | Apr 29, 2011 | Sale | $16.01 | 99,000 | 1,584,990 | 1,832,400 | May 03, 2011, 07:26 PM |
| ORBIMED ADVISORS LLC | Director | May 02, 2011 | Sale | $16.30 | 300 | 4,890 | 17,300 | May 03, 2011, 07:26 PM |
| ORBIMED ADVISORS LLC | Director | May 02, 2011 | Sale | $16.30 | 32,600 | 531,380 | 1,799,800 | May 03, 2011, 07:26 PM |
| ORBIMED ADVISORS LLC | Director | Apr 29, 2011 | Sale | $16.01 | 1,000 | 16,010 | 17,600 | May 03, 2011, 07:26 PM |
| GORDON CARL L | Director | May 02, 2011 | Sale | $16.30 | 32,900 | 536,270 | 1,799,800 | May 03, 2011, 07:20 PM |
| GORDON CARL L | Director | Apr 29, 2011 | Sale | $16.01 | 100,000 | 1,601,000 | 1,832,400 | May 03, 2011, 07:20 PM |
| VAN HEEK G JAN | Director | Apr 25, 2011 | Option Exercise | $1.03 | 30,000 | 30,900 | 46,317 | Apr 27, 2011, 06:44 PM |
| VAN HEEK G JAN | Director | Apr 25, 2011 | Sale | $16.58 | 30,000 | 497,379 | 16,317 | Apr 27, 2011, 06:44 PM |
| VAN HEEK G JAN | Director | Apr 18, 2011 | Sale | $1.03 | 3,000 | 3,090 | 16,317 | Apr 27, 2011, 06:37 PM |
| ORBIMED ADVISORS LLC | Director | Apr 20, 2011 | Sale | $15.79 | 7,600 | 120,004 | 25,700 | Apr 26, 2011, 08:21 PM |
| ORBIMED ADVISORS LLC | Director | Apr 20, 2011 | Sale | $15.79 | 792,400 | 12,511,996 | 2,674,300 | Apr 26, 2011, 08:21 PM |
| GORDON CARL L | Director | Apr 20, 2011 | Sale | $15.79 | 792,400 | 12,511,996 | 2,674,300 | Apr 26, 2011, 08:16 PM |
| GORDON CARL L | Director | Apr 20, 2011 | Sale | $15.79 | 7,600 | 120,004 | 25,700 | Apr 26, 2011, 08:16 PM |
| GORDON CARL L | Director | Apr 21, 2011 | Sale | $16.67 | 750,000 | 12,500,000 | 2,426,667 | Apr 25, 2011, 09:51 PM |
| ORBIMED ADVISORS LLC | Director | Apr 21, 2011 | Sale | $16.67 | 7,100 | 118,333 | 23,333 | Apr 25, 2011, 09:46 PM |
| ORBIMED ADVISORS LLC | Director | Apr 21, 2011 | Sale | $16.67 | 742,900 | 12,381,667 | 2,426,667 | Apr 25, 2011, 09:46 PM |
| GORDON CARL L | Director | Apr 20, 2011 | Sale | $15.79 | 800,000 | 12,632,000 | 2,674,300 | Apr 20, 2011, 09:43 PM |
| GORDON CARL L | Director | Apr 18, 2011 | Sale | $15.18 | 3,000,000 | 45,549,897 | 4,682,029 | Apr 20, 2011, 09:43 PM |
| ORBIMED ADVISORS LLC | Director | Apr 18, 2011 | Sale | $15.18 | 28,200 | 428,168 | 44,832 | Apr 20, 2011, 09:39 PM |
| ORBIMED ADVISORS LLC | Director | Apr 18, 2011 | Sale | $15.18 | 2,971,800 | 45,121,729 | 4,682,029 | Apr 20, 2011, 09:39 PM |
| ORBIMED ADVISORS LLC | Director | Apr 20, 2011 | Sale | $15.79 | 800,000 | 12,632,000 | 2,674,300 | Apr 20, 2011, 09:39 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Apr 18, 2011 | Option Exercise | $2.72 | 300,000 | 815,000 | 363,604 | Apr 20, 2011, 07:49 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Apr 18, 2011 | Sale | $15.76 | 300,000 | 4,728,210 | 63,604 | Apr 20, 2011, 07:49 PM |
| VAN HEEK G JAN | Director | Apr 18, 2011 | Option Exercise | $1.03 | 3,000 | 3,090 | 22,317 | Apr 20, 2011, 07:41 PM |
| VAN HEEK G JAN | Director | Apr 18, 2011 | Sale | $16.51 | 3,000 | 49,530 | 19,317 | Apr 20, 2011, 07:41 PM |
| Soni Paresh | SVP and Head of Development | Apr 19, 2011 | Option Exercise | $1.35 | 80,000 | 108,000 | 80,000 | Apr 20, 2011, 07:39 PM |
| Soni Paresh | SVP and Head of Development | Apr 19, 2011 | Sale | $15.11 | 80,000 | 1,208,624 | 0 | Apr 20, 2011, 07:39 PM |
| Ahlholm Frederick W | Vice President Finance | Apr 20, 2011 | Option Exercise | $1.70 | 31,250 | 53,125 | 31,250 | Apr 20, 2011, 07:38 PM |
| Ahlholm Frederick W | Vice President Finance | Apr 20, 2011 | Sale | $15.88 | 31,250 | 496,344 | 0 | Apr 20, 2011, 07:38 PM |
| Abingworth LLP | 10% Owner | Apr 18, 2011 | Sale | $14.87 | 4,179,174 | 62,143,480 | 7,895,826 | Apr 20, 2011, 04:33 PM |
| Ahlholm Frederick W | Vice President Finance | Apr 04, 2011 | Option Exercise | $1.70 | 31,250 | 53,125 | 31,250 | Apr 06, 2011, 05:42 PM |
| Ahlholm Frederick W | Vice President Finance | Apr 04, 2011 | Sale | $7.48 | 31,250 | 233,688 | 0 | Apr 06, 2011, 05:42 PM |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | Mar 29, 2011 | Sale | $7.25 | 424,900 | 3,080,610 | 8,513,388 | Mar 31, 2011, 03:16 PM |
| GORDON CARL L | Director | Mar 28, 2011 | Sale | $7.35 | 93,100 | 684,285 | 6,438,500 | Mar 28, 2011, 09:45 PM |
| GORDON CARL L | Director | Mar 25, 2011 | Sale | $7.47 | 56,900 | 425,043 | 6,530,700 | Mar 28, 2011, 09:45 PM |
| GORDON CARL L | Director | Mar 24, 2011 | Sale | $7.50 | 23,000 | 172,500 | 6,587,100 | Mar 28, 2011, 09:45 PM |
| ORBIMED ADVISORS LLC | Director | Mar 25, 2011 | Sale | $7.47 | 56,400 | 421,308 | 6,530,700 | Mar 28, 2011, 09:41 PM |
| ORBIMED ADVISORS LLC | Director | Mar 24, 2011 | Sale | $7.50 | 200 | 1,500 | 62,900 | Mar 28, 2011, 09:41 PM |
| ORBIMED ADVISORS LLC | Director | Mar 24, 2011 | Sale | $7.50 | 22,800 | 171,000 | 6,587,100 | Mar 28, 2011, 09:41 PM |
| ORBIMED ADVISORS LLC | Director | Mar 28, 2011 | Sale | $7.35 | 900 | 6,615 | 61,500 | Mar 28, 2011, 09:41 PM |
| ORBIMED ADVISORS LLC | Director | Mar 28, 2011 | Sale | $7.35 | 92,200 | 677,670 | 6,438,500 | Mar 28, 2011, 09:41 PM |
| ORBIMED ADVISORS LLC | Director | Mar 25, 2011 | Sale | $7.47 | 500 | 3,735 | 62,400 | Mar 28, 2011, 09:41 PM |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | Mar 25, 2011 | Sale | $7.50 | 75,100 | 563,333 | 8,938,288 | Mar 28, 2011, 08:37 PM |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | Mar 24, 2011 | Sale | $7.56 | 500,000 | 3,778,000 | 9,013,388 | Mar 28, 2011, 08:37 PM |
| GORDON CARL L | Director | Mar 21, 2011 | Sale | $7.05 | 77,000 | 542,850 | 6,609,900 | Mar 23, 2011, 06:31 PM |
| ORBIMED ADVISORS LLC | Director | Mar 21, 2011 | Sale | $7.05 | 700 | 4,935 | 63,100 | Mar 23, 2011, 06:27 PM |
| ORBIMED ADVISORS LLC | Director | Mar 21, 2011 | Sale | $7.05 | 76,300 | 537,915 | 6,609,900 | Mar 23, 2011, 06:27 PM |
| GORDON CARL L | Director | Mar 15, 2011 | Sale | $7.24 | 50,000 | 362,000 | 6,686,200 | Mar 15, 2011, 09:34 PM |
| GORDON CARL L | Director | Mar 14, 2011 | Sale | $7.33 | 75,000 | 549,750 | 6,735,700 | Mar 15, 2011, 09:34 PM |
| GORDON CARL L | Director | Mar 11, 2011 | Sale | $7.43 | 100,000 | 743,000 | 6,810,000 | Mar 15, 2011, 09:34 PM |
| ORBIMED ADVISORS LLC | Director | Mar 14, 2011 | Sale | $7.33 | 700 | 5,131 | 64,300 | Mar 15, 2011, 09:29 PM |
| ORBIMED ADVISORS LLC | Director | Mar 14, 2011 | Sale | $7.33 | 74,300 | 544,619 | 6,735,700 | Mar 15, 2011, 09:29 PM |
| ORBIMED ADVISORS LLC | Director | Mar 11, 2011 | Sale | $7.43 | 900 | 6,687 | 65,000 | Mar 15, 2011, 09:29 PM |
| ORBIMED ADVISORS LLC | Director | Mar 11, 2011 | Sale | $7.43 | 99,100 | 736,313 | 6,810,000 | Mar 15, 2011, 09:29 PM |
| ORBIMED ADVISORS LLC | Director | Mar 15, 2011 | Sale | $7.24 | 500 | 3,620 | 63,800 | Mar 15, 2011, 09:29 PM |
| ORBIMED ADVISORS LLC | Director | Mar 15, 2011 | Sale | $7.24 | 49,500 | 358,380 | 6,686,200 | Mar 15, 2011, 09:29 PM |
| Abingworth LLP | 10% Owner | Mar 11, 2011 | Sale | $7.50 | 2,750,000 | 20,636,001 | 12,075,000 | Mar 15, 2011, 02:16 PM |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | Mar 11, 2011 | Sale | $7.50 | 2,000,000 | 15,000,000 | 9,513,388 | Mar 14, 2011, 06:35 PM |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | Mar 09, 2011 | Sale | $7.25 | 30,700 | 222,575 | 12,119,688 | Mar 11, 2011, 09:27 PM |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | Mar 10, 2011 | Sale | $7.26 | 606,300 | 4,400,283 | 11,513,388 | Mar 11, 2011, 09:27 PM |
| Abingworth LLP | 10% Owner | Mar 08, 2011 | Sale | $7.50 | 550,000 | 4,125,990 | 14,825,000 | Mar 10, 2011, 04:22 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Mar 09, 2011 | Option Exercise | $1.35 | 10,000 | 13,500 | 63,604 | Mar 09, 2011, 06:22 PM |
| Abingworth LLP | 10% Owner | Mar 04, 2011 | Sale | $7.60 | 100,000 | 760,000 | 15,375,000 | Mar 08, 2011, 05:15 PM |
| GORDON CARL L | Director | Mar 03, 2011 | Sale | $7.76 | 7,000 | 54,320 | 6,976,500 | Mar 07, 2011, 09:51 PM |
| GORDON CARL L | Director | Mar 07, 2011 | Sale | $7.68 | 25,000 | 192,000 | 6,909,100 | Mar 07, 2011, 09:51 PM |
| GORDON CARL L | Director | Mar 04, 2011 | Sale | $7.62 | 43,000 | 327,660 | 6,933,900 | Mar 07, 2011, 09:51 PM |
| ORBIMED ADVISORS LLC | Director | Mar 07, 2011 | Sale | $7.68 | 200 | 1,536 | 65,900 | Mar 07, 2011, 09:45 PM |
| ORBIMED ADVISORS LLC | Director | Mar 07, 2011 | Sale | $7.68 | 24,800 | 190,464 | 6,909,100 | Mar 07, 2011, 09:45 PM |
| ORBIMED ADVISORS LLC | Director | Mar 04, 2011 | Sale | $7.62 | 400 | 3,048 | 66,100 | Mar 07, 2011, 09:45 PM |
| ORBIMED ADVISORS LLC | Director | Mar 04, 2011 | Sale | $7.62 | 42,600 | 324,612 | 6,933,900 | Mar 07, 2011, 09:45 PM |
| ORBIMED ADVISORS LLC | Director | Mar 03, 2011 | Sale | $7.76 | 100 | 776 | 66,500 | Mar 07, 2011, 09:45 PM |
| ORBIMED ADVISORS LLC | Director | Mar 03, 2011 | Sale | $7.76 | 6,900 | 53,544 | 6,976,500 | Mar 07, 2011, 09:45 PM |
| Abingworth LLP | 10% Owner | Mar 02, 2011 | Sale | $7.70 | 1,200,000 | 9,239,040 | 15,475,000 | Mar 04, 2011, 01:31 PM |
| ORBIMED ADVISORS LLC | Director | Feb 28, 2011 | Sale | $7.73 | 99,100 | 766,043 | 7,127,000 | Mar 02, 2011, 08:40 PM |
| ORBIMED ADVISORS LLC | Director | Mar 02, 2011 | Sale | $7.72 | 900 | 6,948 | 66,600 | Mar 02, 2011, 08:40 PM |
| ORBIMED ADVISORS LLC | Director | Mar 02, 2011 | Sale | $7.72 | 94,100 | 726,452 | 6,983,400 | Mar 02, 2011, 08:40 PM |
| ORBIMED ADVISORS LLC | Director | Mar 01, 2011 | Sale | $7.56 | 500 | 3,780 | 67,500 | Mar 02, 2011, 08:40 PM |
| ORBIMED ADVISORS LLC | Director | Mar 01, 2011 | Sale | $7.56 | 49,500 | 374,220 | 7,077,500 | Mar 02, 2011, 08:40 PM |
| ORBIMED ADVISORS LLC | Director | Feb 28, 2011 | Sale | $7.73 | 900 | 6,957 | 68,000 | Mar 02, 2011, 08:40 PM |
| GORDON CARL L | Director | Mar 02, 2011 | Sale | $7.72 | 95,000 | 733,400 | 6,983,400 | Mar 02, 2011, 08:33 PM |
| GORDON CARL L | Director | Mar 01, 2011 | Sale | $7.56 | 50,000 | 378,000 | 7,077,500 | Mar 02, 2011, 08:33 PM |
| GORDON CARL L | Director | Feb 28, 2011 | Sale | $7.73 | 100,000 | 773,000 | 7,127,000 | Mar 02, 2011, 08:33 PM |
| Abingworth LLP | 10% Owner | Mar 01, 2011 | Sale | $7.61 | 50,000 | 380,485 | 16,675,000 | Mar 02, 2011, 01:57 PM |
| Abingworth LLP | 10% Owner | Feb 28, 2011 | Sale | $7.92 | 275,000 | 2,178,137 | 16,725,000 | Mar 02, 2011, 01:57 PM |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | Feb 25, 2011 | Sale | $8.13 | 363,000 | 2,952,787 | 12,150,388 | Mar 01, 2011, 05:24 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Feb 25, 2011 | Option Exercise | $1.35 | 60,000 | 81,000 | 103,604 | Feb 28, 2011, 07:08 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Feb 25, 2011 | Sale | $8.16 | 60,000 | 489,755 | 53,604 | Feb 28, 2011, 07:08 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Feb 22, 2011 | Option Exercise | $1.35 | 100,000 | 135,000 | 153,604 | Feb 24, 2011, 06:05 PM |
| Zakrzewski Joseph S | Chief Executive Officer | Feb 22, 2011 | Sale | $8.54 | 100,000 | 854,060 | 53,604 | Feb 24, 2011, 06:05 PM |
| Soni Paresh | SVP and Head of Development | Feb 22, 2011 | Option Exercise | $1.35 | 120,000 | 162,000 | 120,000 | Feb 24, 2011, 06:01 PM |
| Soni Paresh | SVP and Head of Development | Feb 22, 2011 | Sale | $8.49 | 120,000 | 1,018,764 | 0 | Feb 24, 2011, 06:01 PM |
Load More Insider Transactions
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Option Exercise
| Owner | Relationship | Date | Value($) |
| Berg Aaron | EVP, President US | 01/31/2024 | 50,619 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2024 | 51,072 |
| Reilly Thomas Charles | EVP and CFO | 01/31/2024 | 30,444 |
| Holt Patrick | President and CEO | 01/22/2024 | 15,724 |
| Ketchum Steven B | Chief Scientific Officer | 01/10/2024 | 27,422 |
| Reilly Thomas Charles | EVP and CFO | 01/10/2024 | 27,475 |
| Berg Aaron | EVP, President US | 01/10/2024 | 27,368 |
| Ketchum Steven B | Chief Scientific Officer | 01/04/2024 | 6,725 |
| Berg Aaron | EVP, President US | 01/04/2024 | 13,450 |
| Ketchum Steven B | Chief Scientific Officer | 12/29/2023 | 20,467 |
| Berg Aaron | EVP, President US | 12/29/2023 | 20,467 |
| Ketchum Steven B | Chief Scientific Officer | 12/12/2023 | 26,963 |
| Holt Patrick | President and CEO | 08/16/2023 | 312,315 |
| Berg Aaron | EVP, President US | 07/31/2023 | 13,998 |
| Ketchum Steven B | Chief Scientific Officer | 07/31/2023 | 13,998 |
| Reilly Thomas Charles | SVP and CFO | 07/01/2023 | 9,769 |
| Reilly Thomas Charles | SVP and CFO | 06/20/2023 | 19,536 |
| Ketchum Steven B | Chief Scientific Officer | 02/28/2023 | 15,668 |
| Berg Aaron | EVP, President US | 02/28/2023 | 15,668 |
| Berg Aaron | EVP, President US | 02/21/2023 | 50,692 |
| Berg Aaron | EVP, President US | 01/31/2023 | 25,495 |
| Mikhail Karim | President and CEO | 02/21/2023 | 18,002 |
| Mikhail Karim | President and CEO | 01/31/2023 | 115,897 |
| Ketchum Steven B | Chief Scientific Officer | 02/21/2023 | 26,136 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2023 | 25,493 |
| Berg Aaron | EVP, President US | 12/30/2022 | 19,797 |
| Ketchum Steven B | Chief Scientific Officer | 12/30/2022 | 19,797 |
| Mikhail Karim | President and CEO | 12/30/2022 | 1,537 |
| Marks Jason M. | EVP,Chief Global Legal Officer | 08/19/2022 | 18,267 |
| Kalb Michael Wayne | SVP and CFO | 08/01/2022 | 39,477 |
| Kalb Michael Wayne | SVP and CFO | 07/29/2022 | 22,903 |
| Berg Aaron | EVP, President US | 07/29/2022 | 10,881 |
| Ketchum Steven B | Chief Scientific Officer | 07/29/2022 | 10,881 |
| Mikhail Karim | President and CEO | 07/01/2022 | 16,062 |
| WOLD OLSEN PER | Director | 06/13/2022 | 92,730 |
| Mikhail Karim | President and CEO | 04/12/2022 | 69,114 |
| Kalb Michael Wayne | SVP and CFO | 02/28/2022 | 20,317 |
| Ketchum Steven B | Chief Scientific Officer | 02/28/2022 | 18,011 |
| Kalb Michael Wayne | SVP and CFO | 01/31/2022 | 17,865 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2022 | 17,207 |
| Kalb Michael Wayne | SVP and CFO | 12/31/2021 | 85,020 |
| Mikhail Karim | President and CEO | 12/31/2021 | 12,985 |
| Zakrzewski Joseph S | Director | 12/15/2021 | 6,310 |
| Zakrzewski Joseph S | Director | 12/14/2021 | 32,689 |
| Berg Aaron | EVP, President US | 08/31/2021 | 16,681 |
| Kalb Michael Wayne | SVP and CFO | 08/31/2021 | 16,681 |
| Ketchum Steven B | Chief Scientific Officer | 08/31/2021 | 17,324 |
| Kalb Michael Wayne | SVP and CFO | 08/12/2021 | 281,800 |
| Kalb Michael Wayne | SVP and CFO | 08/12/2021 | 630,240 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 07/30/2021 | 12,466 |
| Kalb Michael Wayne | SVP and CFO | 07/30/2021 | 12,466 |
| Ketchum Steven B | Chief Scientific Officer | 07/30/2021 | 12,946 |
| Kennedy Joseph T | General Counsel | 07/30/2021 | 15,744 |
| THERO JOHN F | President and CEO | 07/30/2021 | 43,901 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 06/30/2021 | 13,489 |
| Kalb Michael Wayne | SVP and CFO | 06/30/2021 | 13,489 |
| Ketchum Steven B | Chief Scientific Officer | 06/30/2021 | 14,009 |
| Kennedy Joseph T | General Counsel | 06/30/2021 | 17,037 |
| THERO JOHN F | President and CEO | 06/30/2021 | 47,506 |
| STACK DAVID M | Director | 06/04/2021 | 45,350 |
| STACK DAVID M | Director | 06/03/2021 | 23,115 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 05/28/2021 | 13,674 |
| Kalb Michael Wayne | SVP and CFO | 05/28/2021 | 13,597 |
| Kennedy Joseph T | General Counsel | 05/28/2021 | 17,266 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 04/30/2021 | 80,960 |
| Kalb Michael Wayne | SVP and CFO | 04/30/2021 | 15,694 |
| Kennedy Joseph T | General Counsel | 04/30/2021 | 19,928 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 03/31/2021 | 19,186 |
| Kalb Michael Wayne | SVP and CFO | 03/31/2021 | 19,078 |
| Kennedy Joseph T | General Counsel | 03/31/2021 | 24,225 |
| THERO JOHN F | President and CEO | 03/31/2021 | 67,547 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 02/26/2021 | 74,524 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 02/25/2021 | 318,557 |
| Kalb Michael Wayne | SVP and CFO | 02/25/2021 | 316,784 |
| Kalb Michael Wayne | SVP and CFO | 02/26/2021 | 74,511 |
| Ketchum Steven B | Chief Scientific Officer | 02/26/2021 | 77,395 |
| Ketchum Steven B | Chief Scientific Officer | 02/25/2021 | 330,887 |
| Kennedy Joseph T | General Counsel | 02/26/2021 | 83,603 |
| Kennedy Joseph T | General Counsel | 02/25/2021 | 402,522 |
| THERO JOHN F | President and CEO | 02/26/2021 | 228,924 |
| THERO JOHN F | President and CEO | 02/25/2021 | 1,122,295 |
| Ketchum Steven B | Chief Scientific Officer | 02/01/2021 | 485,882 |
| Ketchum Steven B | Chief Scientific Officer | 02/01/2021 | 1,754,134 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 01/29/2021 | 47,108 |
| Kalb Michael Wayne | SVP and CFO | 01/29/2021 | 111,960 |
| Ketchum Steven B | Chief Scientific Officer | 01/29/2021 | 161,513 |
| Ketchum Steven B | Chief Scientific Officer | 01/27/2021 | 764,566 |
| Ketchum Steven B | Chief Scientific Officer | 01/27/2021 | 3,378,131 |
| Kennedy Joseph T | General Counsel | 01/29/2021 | 125,333 |
| THERO JOHN F | President and CEO | 01/29/2021 | 620,715 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 12/31/2020 | 7,876 |
| Kalb Michael Wayne | SVP and CFO | 12/31/2020 | 7,835 |
| Ketchum Steven B | Chief Scientific Officer | 12/31/2020 | 7,876 |
| Kennedy Joseph T | General Counsel | 12/31/2020 | 9,947 |
| THERO JOHN F | President and CEO | 12/31/2020 | 27,729 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 11/30/2020 | 6,928 |
| STACK DAVID M | Director | 11/30/2020 | 121,518 |
| Kalb Michael Wayne | SVP and CFO | 11/30/2020 | 6,891 |
| Ketchum Steven B | Chief Scientific Officer | 11/30/2020 | 6,928 |
| Kennedy Joseph T | General Counsel | 11/30/2020 | 8,749 |
| THERO JOHN F | President and CEO | 11/30/2020 | 24,389 |
| THERO JOHN F | President and CEO | 11/10/2020 | 2,091,887 |
| THERO JOHN F | President and CEO | 11/09/2020 | 458,113 |
| THERO JOHN F | President and CEO | 11/11/2020 | 1,681,183 |
| THERO JOHN F | President and CEO | 11/10/2020 | 635,975 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 10/30/2020 | 7,319 |
| Kalb Michael Wayne | SVP and CFO | 10/30/2020 | 7,280 |
| Ketchum Steven B | Chief Scientific Officer | 10/30/2020 | 7,319 |
| Kennedy Joseph T | General Counsel | 10/30/2020 | 9,244 |
| Zakrzewski Joseph S | Director | 10/21/2020 | 340,000 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 09/30/2020 | 6,084 |
| Ketchum Steven B | Chief Scientific Officer | 09/30/2020 | 6,084 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 08/31/2020 | 11,084 |
| Kalb Michael Wayne | SVP and CFO | 08/31/2020 | 11,011 |
| Ketchum Steven B | Chief Scientific Officer | 08/31/2020 | 11,084 |
| Kennedy Joseph T | General Counsel | 08/31/2020 | 13,999 |
| THERO JOHN F | President and CEO | 08/31/2020 | 39,023 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 07/31/2020 | 9,938 |
| Kalb Michael Wayne | SVP and CFO | 07/31/2020 | 9,872 |
| Ketchum Steven B | Chief Scientific Officer | 07/31/2020 | 9,938 |
| Kennedy Joseph T | General Counsel | 07/31/2020 | 12,547 |
| THERO JOHN F | President and CEO | 07/31/2020 | 34,953 |
| THERO JOHN F | President and CEO | 06/30/2020 | 35,629 |
| Kennedy Joseph T | General Counsel | 06/30/2020 | 12,781 |
| Ketchum Steven B | Chief Scientific Officer | 06/30/2020 | 10,120 |
| Kalb Michael Wayne | SVP and CFO | 06/30/2020 | 10,053 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 06/30/2020 | 10,120 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 05/29/2020 | 10,331 |
| Kalb Michael Wayne | SVP and CFO | 05/29/2020 | 10,276 |
| Ketchum Steven B | Chief Scientific Officer | 05/29/2020 | 10,331 |
| Kennedy Joseph T | General Counsel | 05/29/2020 | 13,048 |
| THERO JOHN F | President and CEO | 05/29/2020 | 36,372 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 04/30/2020 | 12,440 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 05/01/2020 | 97,446 |
| Kalb Michael Wayne | SVP and CFO | 04/30/2020 | 12,373 |
| Ketchum Steven B | Chief Scientific Officer | 04/30/2020 | 12,440 |
| Kennedy Joseph T | General Counsel | 04/30/2020 | 15,711 |
| THERO JOHN F | President and CEO | 04/30/2020 | 43,795 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 03/31/2020 | 20,451 |
| Kalb Michael Wayne | SVP and CFO | 03/31/2020 | 20,343 |
| Ketchum Steven B | Chief Scientific Officer | 03/31/2020 | 20,451 |
| THERO JOHN F | President and CEO | 03/31/2020 | 72,001 |
| THERO JOHN F | President and CEO | 03/04/2020 | 3,198,700 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 02/28/2020 | 22,093 |
| Kalb Michael Wayne | SVP and CFO | 02/28/2020 | 21,976 |
| Ketchum Steven B | Chief Scientific Officer | 02/28/2020 | 22,093 |
| THERO JOHN F | President and CEO | 02/28/2020 | 77,780 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 02/25/2020 | 449,802 |
| Kalb Michael Wayne | SVP and CFO | 02/25/2020 | 447,235 |
| Ketchum Steven B | Chief Scientific Officer | 02/25/2020 | 449,802 |
| Kennedy Joseph T | General Counsel | 02/25/2020 | 568,256 |
| THERO JOHN F | President and CEO | 02/25/2020 | 1,584,380 |
| THERO JOHN F | President and CEO | 01/31/2020 | 2,366,425 |
| Kennedy Joseph T | General Counsel | 01/31/2020 | 754,593 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2020 | 639,801 |
| Kalb Michael Wayne | SVP and CFO | 01/31/2020 | 636,412 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 01/31/2020 | 276,975 |
| Zakrzewski Joseph S | Director | 01/03/2020 | 1,020,000 |
| Zakrzewski Joseph S | Director | 01/03/2020 | 6,282,870 |
| Zakrzewski Joseph S | Director | 12/16/2019 | 900,000 |
| Zakrzewski Joseph S | Director | 12/16/2019 | 2,583,380 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 12/16/2019 | 544,988 |
| Kalb Michael Wayne | SVP and CFO | 12/16/2019 | 54,750 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 12/16/2019 | 1,101,364 |
| Kalb Michael Wayne | SVP and CFO | 12/16/2019 | 584,012 |
| THERO JOHN F | President and CEO | 11/19/2019 | 6,217,371 |
| Ekman Lars | Director | 11/12/2019 | 555,840 |
| Ekman Lars | Director | 11/12/2019 | 746,759 |
| THERO JOHN F | President and CEO | 11/11/2019 | 8,143,452 |
| Ekman Lars | Director | 11/05/2019 | 92,160 |
| Ekman Lars | Director | 11/05/2019 | 115,230 |
| THERO JOHN F | President and CEO | 10/28/2019 | 29,003 |
| THERO JOHN F | President and CEO | 10/07/2019 | 7,154,478 |
| Ketchum Steven B | Chief Scientific Officer | 10/07/2019 | 1,437,330 |
| Kennedy Joseph T | General Counsel | 10/07/2019 | 1,509,382 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 10/07/2019 | 1,466,387 |
| Ekman Lars | Director | 09/03/2019 | 320,280 |
| Ekman Lars | Director | 09/03/2019 | 1,365,722 |
| THERO JOHN F | President and CEO | 08/21/2019 | 62,498 |
| THERO JOHN F | President and CEO | 08/21/2019 | 300,010 |
| STACK DAVID M | Director | 07/11/2019 | 121,035 |
| STACK DAVID M | Director | 07/11/2019 | 1,158,354 |
| Zakrzewski Joseph S | Director | 07/05/2019 | 900,000 |
| Zakrzewski Joseph S | Director | 07/05/2019 | 2,381,580 |
| Kennedy Joseph T | General Counsel | 07/01/2019 | 69,962 |
| Kennedy Joseph T | General Counsel | 07/01/2019 | 1,057,906 |
| Kalb Michael Wayne | SVP and CFO | 07/01/2019 | 109,500 |
| Kalb Michael Wayne | SVP and CFO | 07/01/2019 | 983,270 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 07/03/2019 | 81,900 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 07/02/2019 | 173,910 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 07/02/2019 | 1,442,141 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 07/03/2019 | 662,238 |
| Kennedy Joseph T | General Counsel | 06/30/2019 | 513,738 |
| THERO JOHN F | President and CEO | 06/30/2019 | 286,138 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 06/24/2019 | 250,000 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 06/24/2019 | 2,104,521 |
| Zakrzewski Joseph S | Director | 06/18/2019 | 340,000 |
| Zakrzewski Joseph S | Director | 06/18/2019 | 1,902,090 |
| Kennedy Joseph T | General Counsel | 05/31/2019 | 69,925 |
| Kennedy Joseph T | General Counsel | 05/31/2019 | 488,058 |
| STACK DAVID M | Director | 05/29/2019 | 108,495 |
| STACK DAVID M | Director | 05/29/2019 | 623,534 |
| STACK DAVID M | Director | 05/17/2019 | 42,289 |
| STACK DAVID M | Director | 05/17/2019 | 237,139 |
| Ketchum Steven B | Chief Scientific Officer | 04/30/2019 | 22,235 |
| Ketchum Steven B | Chief Scientific Officer | 04/30/2019 | 178,107 |
| Kennedy Joseph T | General Counsel | 04/30/2019 | 69,927 |
| Kennedy Joseph T | General Counsel | 04/30/2019 | 508,839 |
| Berg Aaron | CHIEF COMMERCIAL OFFICER | 05/01/2019 | 239,454 |
| THERO JOHN F | President and CEO | 03/31/2019 | 306,355 |
| Ketchum Steven B | Chief Scientific Officer | 04/01/2019 | 22,236 |
| Ketchum Steven B | Chief Scientific Officer | 04/01/2019 | 191,392 |
| Kennedy Joseph T | General Counsel | 03/31/2019 | 550,036 |
| Kennedy Joseph T | General Counsel | 04/01/2019 | 69,926 |
| Kennedy Joseph T | General Counsel | 04/01/2019 | 1,086,122 |
| THERO JOHN F | President and CEO | 03/04/2019 | 5,327,234 |
| Ekman Lars | Director | 03/04/2019 | 276,743 |
| Ekman Lars | Director | 03/04/2019 | 2,884,905 |
| Ketchum Steven B | Chief Scientific Officer | 03/01/2019 | 115,000 |
| Ketchum Steven B | Chief Scientific Officer | 02/28/2019 | 22,239 |
| Ketchum Steven B | Chief Scientific Officer | 03/01/2019 | 1,016,275 |
| Ketchum Steven B | Chief Scientific Officer | 02/28/2019 | 197,249 |
| Kalb Michael Wayne | SVP and CFO | 03/01/2019 | 283,350 |
| Kalb Michael Wayne | SVP and CFO | 03/01/2019 | 2,209,098 |
| Kennedy Joseph T | General Counsel | 02/28/2019 | 69,928 |
| Kennedy Joseph T | General Counsel | 02/28/2019 | 564,172 |
| Zakrzewski Joseph S | Director | 02/22/2019 | 1,572,312 |
| Zakrzewski Joseph S | Director | 02/22/2019 | 3,594,437 |
| VAN HEEK G JAN | Director | 02/22/2019 | 857,170 |
| VAN HEEK G JAN | Director | 02/22/2019 | 4,071,423 |
| Peterson Kristine | Director | 02/22/2019 | 947,730 |
| Peterson Kristine | Director | 02/22/2019 | 3,274,038 |
| Kalb Michael Wayne | SVP and CFO | 02/22/2019 | 147,500 |
| Kalb Michael Wayne | SVP and CFO | 02/22/2019 | 948,500 |
| Kalb Michael Wayne | SVP and CFO | 02/15/2019 | 439,525 |
| THERO JOHN F | President and CEO | 01/31/2019 | 2,425,418 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2019 | 685,765 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2019 | 22,235 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2019 | 166,875 |
| Ketchum Steven B | Chief Scientific Officer | 02/01/2019 | 477,498 |
| Kennedy Joseph T | General Counsel | 01/31/2019 | 744,716 |
| Kennedy Joseph T | General Counsel | 01/31/2019 | 71,910 |
| Kennedy Joseph T | General Counsel | 01/31/2019 | 745,468 |
| Kalb Michael Wayne | SVP and CFO | 01/31/2019 | 456,279 |
| Kennedy Joseph T | General Counsel | 01/24/2019 | 2,370,612 |
| Kennedy Joseph T | General Counsel | 01/23/2019 | 1,840,134 |
| Kennedy Joseph T | General Counsel | 01/22/2019 | 804,656 |
| Kennedy Joseph T | General Counsel | 01/24/2019 | 10,754,717 |
| Kennedy Joseph T | General Counsel | 01/23/2019 | 4,591,310 |
| Kennedy Joseph T | General Counsel | 01/22/2019 | 3,141,884 |
| Zakrzewski Joseph S | Director | 01/10/2019 | 680,000 |
| Zakrzewski Joseph S | Director | 01/10/2019 | 3,396,390 |
| STACK DAVID M | Director | 01/10/2019 | 577,855 |
| STACK DAVID M | Director | 01/10/2019 | 79,172 |
| STACK DAVID M | Director | 01/10/2019 | 1,774,296 |
| STACK DAVID M | Director | 01/10/2019 | 484,776 |
| Kennedy Joseph T | General Counsel | 01/11/2019 | 9,360 |
| Kennedy Joseph T | General Counsel | 01/11/2019 | 60,033 |
| Kalb Michael Wayne | SVP and CFO | 01/09/2019 | 438,000 |
| Kalb Michael Wayne | SVP and CFO | 01/09/2019 | 3,051,080 |
| Ekman Lars | Director | 01/10/2019 | 103,428 |
| Ekman Lars | Director | 01/10/2019 | 2,426,489 |
| Zakrzewski Joseph S | Director | 01/02/2019 | 1,237,250 |
| Zakrzewski Joseph S | Director | 01/02/2019 | 5,015,703 |
| Zakrzewski Joseph S | Director | 12/28/2018 | 1,866,668 |
| Kennedy Joseph T | General Counsel | 12/31/2018 | 350,794 |
| Kennedy Joseph T | General Counsel | 12/31/2018 | 363,547 |
| Ketchum Steven B | Chief Scientific Officer | 12/31/2018 | 40,985 |
| Ketchum Steven B | Chief Scientific Officer | 12/31/2018 | 230,212 |
| THERO JOHN F | President and CEO | 12/31/2018 | 195,383 |
| Ketchum Steven B | Chief Scientific Officer | 11/30/2018 | 40,988 |
| Ketchum Steven B | Chief Scientific Officer | 11/30/2018 | 303,174 |
| Kennedy Joseph T | General Counsel | 11/30/2018 | 52,510 |
| Kennedy Joseph T | General Counsel | 11/30/2018 | 414,998 |
| THERO JOHN F | President and CEO | 11/12/2018 | 550,275 |
| THERO JOHN F | President and CEO | 11/12/2018 | 11,587,896 |
| Ketchum Steven B | Chief Scientific Officer | 10/31/2018 | 40,988 |
| Ketchum Steven B | Chief Scientific Officer | 10/31/2018 | 353,454 |
| Kennedy Joseph T | General Counsel | 10/31/2018 | 52,513 |
| Kennedy Joseph T | General Counsel | 10/31/2018 | 483,362 |
| THERO JOHN F | President and CEO | 09/30/2018 | 240,096 |
| Ketchum Steven B | Chief Scientific Officer | 10/01/2018 | 916,893 |
| Ketchum Steven B | Chief Scientific Officer | 09/28/2018 | 1,754,000 |
| Ketchum Steven B | Chief Scientific Officer | 09/28/2018 | 3,100,000 |
| Ketchum Steven B | Chief Scientific Officer | 10/01/2018 | 2,005,589 |
| Kennedy Joseph T | General Counsel | 09/30/2018 | 431,074 |
| Kennedy Joseph T | General Counsel | 10/01/2018 | 52,510 |
| Kennedy Joseph T | General Counsel | 10/01/2018 | 844,528 |
| Zakrzewski Joseph S | Director | 09/24/2018 | 1,700,000 |
| Zakrzewski Joseph S | Director | 09/24/2018 | 5,299,334 |
| Ketchum Steven B | Chief Scientific Officer | 09/25/2018 | 1,754,000 |
| Ketchum Steven B | Chief Scientific Officer | 09/24/2018 | 2,366,711 |
| Ketchum Steven B | Chief Scientific Officer | 09/25/2018 | 2,700,000 |
| Ketchum Steven B | Chief Scientific Officer | 09/24/2018 | 7,060,024 |
| Kennedy Joseph T | General Counsel | 09/24/2018 | 2,393,014 |
| Kennedy Joseph T | General Counsel | 09/24/2018 | 11,400,975 |
| Kalb Michael Wayne | SVP and CFO | 09/24/2018 | 328,500 |
| Kalb Michael Wayne | SVP and CFO | 09/24/2018 | 1,562,751 |
| THERO JOHN F | President and CEO | 09/22/2018 | 1,488,649 |
| THERO JOHN F | President and CEO | 06/30/2018 | 45,599 |
| Kennedy Joseph T | General Counsel | 06/30/2018 | 81,870 |
| Kennedy Joseph T | General Counsel | 07/02/2018 | 80,955 |
| THERO JOHN F | President and CEO | 03/31/2018 | 44,419 |
| Kennedy Joseph T | General Counsel | 03/31/2018 | 79,750 |
| Kennedy Joseph T | General Counsel | 04/03/2018 | 55,052 |
| Kennedy Joseph T | General Counsel | 04/02/2018 | 23,020 |
| THERO JOHN F | President and CEO | 01/31/2018 | 756,475 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2018 | 219,949 |
| Kennedy Joseph T | General Counsel | 01/31/2018 | 230,999 |
| Kennedy Joseph T | General Counsel | 01/31/2018 | 167,388 |
| Kalb Michael Wayne | SVP and CFO | 01/31/2018 | 53,635 |
| Ketchum Steven B | Chief Scientific Officer | 01/23/2018 | 275,818 |
| Ketchum Steven B | Chief Scientific Officer | 01/23/2018 | 596,430 |
| Kennedy Joseph T | General Counsel | 01/16/2018 | 41,300 |
| Kennedy Joseph T | General Counsel | 01/12/2018 | 41,128 |
| Kennedy Joseph T | General Counsel | 01/17/2018 | 127,022 |
| Ketchum Steven B | Chief Scientific Officer | 01/11/2018 | 5,328 |
| Ketchum Steven B | Chief Scientific Officer | 01/11/2018 | 11,493 |
| Ketchum Steven B | Chief Scientific Officer | 01/05/2018 | 131,953 |
| Ketchum Steven B | Chief Scientific Officer | 01/05/2018 | 284,631 |
| Ketchum Steven B | Chief Scientific Officer | 01/02/2018 | 153,583 |
| Ketchum Steven B | Chief Scientific Officer | 01/02/2018 | 545,092 |
| THERO JOHN F | President and CEO | 12/31/2017 | 63,085 |
| Kennedy Joseph T | General Counsel | 12/31/2017 | 111,819 |
| THERO JOHN F | President and CEO | 11/30/2017 | 32,446 |
| Ketchum Steven B | Chief Scientific Officer | 10/05/2017 | 221,199 |
| THERO JOHN F | President and CEO | 09/30/2017 | 55,062 |
| Kennedy Joseph T | General Counsel | 09/30/2017 | 97,598 |
| THERO JOHN F | President and CEO | 06/30/2017 | 63,400 |
| Kennedy Joseph T | General Counsel | 06/30/2017 | 112,377 |
| Kennedy Joseph T | General Counsel | 07/03/2017 | 209,158 |
| Kennedy Joseph T | General Counsel | 06/30/2017 | 417,950 |
| Kennedy Joseph T | General Counsel | 06/29/2017 | 603,824 |
| Kennedy Joseph T | General Counsel | 03/31/2017 | 86,339 |
| THERO JOHN F | President and CEO | 03/31/2017 | 50,342 |
| THERO JOHN F | President and CEO | 01/31/2017 | 688,202 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2017 | 208,601 |
| Kennedy Joseph T | General Counsel | 01/31/2017 | 225,349 |
| Kennedy Joseph T | General Counsel | 12/31/2016 | 85,886 |
| THERO JOHN F | President and CEO | 12/31/2016 | 62,198 |
| Kennedy Joseph T | General Counsel | 11/09/2016 | 372,042 |
| Kennedy Joseph T | General Counsel | 09/30/2016 | 88,953 |
| THERO JOHN F | President and CEO | 09/30/2016 | 64,419 |
| THERO JOHN F | President and CEO | 06/30/2016 | 31,793 |
| Kennedy Joseph T | General Counsel | 06/30/2016 | 60,232 |
| Kennedy Joseph T | General Counsel | 03/31/2016 | 30,725 |
| THERO JOHN F | President and CEO | 03/31/2016 | 22,520 |
| THERO JOHN F | President and CEO | 02/01/2016 | 34,250 |
| THERO JOHN F | President and CEO | 01/31/2016 | 234,134 |
| Ketchum Steven B | Chief Scientific Officer | 01/31/2016 | 57,842 |
| Kennedy Joseph T | General Counsel | 01/31/2016 | 64,710 |
| Farrell Michael James | VP, Finance | 01/31/2016 | 15,772 |
| Kennedy Joseph T | General Counsel | 12/31/2015 | 37,955 |
| Kennedy Joseph T | General Counsel | 10/05/2015 | 4,815 |
| Kennedy Joseph T | General Counsel | 09/30/2015 | 34,227 |
| THERO JOHN F | President and CEO | 08/11/2015 | 47,000 |
| Farrell Michael James | Controller | 11/11/2014 | 4,606 |
| THERO JOHN F | President, Chief Exec. Officer | 11/11/2014 | 24,000 |
| THERO JOHN F | President, Chief Exec. Officer | 11/12/2014 | 17,600 |
| Ekman Lars | Director | 11/20/2013 | 72,000 |
| THERO JOHN F | President | 11/20/2013 | 9,500 |
| Zakrzewski Joseph S | Chief Executive Officer | 11/18/2013 | 78,197 |
| VAN HEEK G JAN | Director | 07/10/2013 | 9,810 |
| Zakrzewski Joseph S | Chief Executive Officer | 06/25/2013 | 13,500 |
| Zakrzewski Joseph S | Chief Executive Officer | 06/21/2013 | 13,500 |
| THERO JOHN F | President | 05/29/2013 | 14,850 |
| Zakrzewski Joseph S | Chief Executive Officer | 04/25/2013 | 13,500 |
| VAN HEEK G JAN | Director | 04/10/2013 | 9,808 |
| THERO JOHN F | President | 01/30/2013 | 13,500 |
| VAN HEEK G JAN | Director | 01/10/2013 | 7,935 |
| VAN HEEK G JAN | Director | 10/10/2012 | 7,930 |
| Zakrzewski Joseph S | Chief Executive Officer | 10/01/2012 | 202,500 |
| Zakrzewski Joseph S | Chief Executive Officer | 10/01/2012 | 1,884,315 |
| THERO JOHN F | President | 09/24/2012 | 13,500 |
| THERO JOHN F | President | 09/11/2012 | 13,500 |
| HEALY JAMES | Director | 08/31/2012 | 30,900 |
| GORDON CARL L | Director | 09/04/2012 | 3,372,992 |
| ORBIMED ADVISORS LLC | Director | 09/04/2012 | 3,372,992 |
| HEALY JAMES | Director | 08/14/2012 | 1,212,300 |
| GORDON CARL L | Director | 07/27/2012 | 5,350,691 |
| ORBIMED ADVISORS LLC | Director | 07/27/2012 | 50,483 |
| ORBIMED ADVISORS LLC | Director | 07/27/2012 | 5,300,207 |
| Zakrzewski Joseph S | Chief Executive Officer | 07/27/2012 | 202,500 |
| Zakrzewski Joseph S | Chief Executive Officer | 07/27/2012 | 2,147,192 |
| THERO JOHN F | President | 07/27/2012 | 713,750 |
| THERO JOHN F | President | 07/27/2012 | 4,315,862 |
| Kennedy Joseph T | Senior VP and General Counsel | 07/27/2012 | 96,290 |
| Huff Paul | Chief Commercial Officer | 07/27/2012 | 96,290 |
| SEDLACK STUART D | Senior Vice President | 07/27/2012 | 96,290 |
| VAN HEEK G JAN | Director | 07/10/2012 | 7,934 |
| Huff Paul | Chief Commercial Officer | 06/27/2012 | 429,831 |
| Huff Paul | Chief Commercial Officer | 06/26/2012 | 9,669 |
| Huff Paul | Chief Commercial Officer | 06/27/2012 | 734,204 |
| Huff Paul | Chief Commercial Officer | 06/26/2012 | 14,870 |
| GORDON CARL L | Director | 06/19/2012 | 7,986,701 |
| ORBIMED ADVISORS LLC | Director | 06/19/2012 | 76,185 |
| ORBIMED ADVISORS LLC | Director | 06/19/2012 | 7,892,242 |
| Huff Paul | Chief Commercial Officer | 06/18/2012 | 1,432,111 |
| Huff Paul | Chief Commercial Officer | 06/15/2012 | 879 |
| Huff Paul | Chief Commercial Officer | 06/15/2012 | 1,200 |
| Huff Paul | Chief Commercial Officer | 06/18/2012 | 1,955,524 |
| Huff Paul | Chief Commercial Officer | 06/07/2012 | 111,008 |
| Huff Paul | Chief Commercial Officer | 06/07/2012 | 201,635 |
| Zakrzewski Joseph S | Chief Executive Officer | 05/29/2012 | 202,500 |
| Zakrzewski Joseph S | Chief Executive Officer | 05/29/2012 | 1,795,215 |
| Abingworth LLP | 10% Owner | 04/19/2012 | 6,586,347 |
| Abingworth LLP | 10% Owner | 04/18/2012 | 15,505,584 |
| Abingworth LLP | 10% Owner | 04/17/2012 | 16,454,204 |
| Abingworth LLP | 10% Owner | 04/17/2012 | 16,454,204 |
| Abingworth LLP | 10% Owner | 04/19/2012 | 6,586,347 |
| Abingworth LLP | 10% Owner | 04/18/2012 | 15,505,584 |
| VAN HEEK G JAN | Director | 04/10/2012 | 7,929 |
| THERO JOHN F | President | 04/09/2012 | 203,750 |
| THERO JOHN F | President | 04/09/2012 | 1,503,072 |
| Abingworth LLP | 10% Owner | 04/03/2012 | 25,300,000 |
| HEALY JAMES | Director | 04/03/2012 | 19,059,665 |
| HEALY JAMES | Director | 04/02/2012 | 2,905,286 |
| HEALY JAMES | Director | 03/29/2012 | 10,910,804 |
| HEALY JAMES | Director | 03/28/2012 | 73,922 |
| Zakrzewski Joseph S | Chief Executive Officer | 03/23/2012 | 216,000 |
| Zakrzewski Joseph S | Chief Executive Officer | 03/23/2012 | 1,854,560 |
| HEALY JAMES | Director | 01/27/2012 | 61,800 |
| VAN HEEK G JAN | Director | 01/10/2012 | 6,312 |
| Zakrzewski Joseph S | Chief Executive Officer | 11/07/2011 | 6,750 |
| VAN HEEK G JAN | Director | 10/11/2011 | 6,307 |
| Anderson Joseph | Director | 10/11/2011 | 7,879 |
| Zakrzewski Joseph S | Chief Executive Officer | 08/22/2011 | 6,750 |
| Zakrzewski Joseph S | Chief Executive Officer | 07/15/2011 | 6,750 |
| Zakrzewski Joseph S | Chief Executive Officer | 07/15/2011 | 6,750 |
| VAN HEEK G JAN | Director | 07/11/2011 | 6,310 |
| Anderson Joseph | Director | 07/11/2011 | 6,636 |
| Anderson Joseph | Director | 10/11/2010 | 6,387 |
| Anderson Joseph | Director | 07/12/2010 | 6,386 |
| Anderson Joseph | Director | 04/12/2010 | 6,386 |
| Anderson Joseph | Director | 04/11/2011 | 6,384 |
| Anderson Joseph | Director | 01/10/2011 | 6,378 |
| VAN HEEK G JAN | Director | 04/11/2011 | 6,307 |
| ORBIMED ADVISORS LLC | Director | 04/29/2011 | 1,584,990 |
| ORBIMED ADVISORS LLC | Director | 05/02/2011 | 4,890 |
| ORBIMED ADVISORS LLC | Director | 05/02/2011 | 531,380 |
| ORBIMED ADVISORS LLC | Director | 04/29/2011 | 16,010 |
| GORDON CARL L | Director | 05/02/2011 | 536,270 |
| GORDON CARL L | Director | 04/29/2011 | 1,601,000 |
| VAN HEEK G JAN | Director | 04/25/2011 | 30,900 |
| VAN HEEK G JAN | Director | 04/25/2011 | 497,379 |
| VAN HEEK G JAN | Director | 04/18/2011 | 3,090 |
| ORBIMED ADVISORS LLC | Director | 04/20/2011 | 120,004 |
| ORBIMED ADVISORS LLC | Director | 04/20/2011 | 12,511,996 |
| GORDON CARL L | Director | 04/20/2011 | 12,511,996 |
| GORDON CARL L | Director | 04/20/2011 | 120,004 |
| GORDON CARL L | Director | 04/21/2011 | 12,500,000 |
| ORBIMED ADVISORS LLC | Director | 04/21/2011 | 118,333 |
| ORBIMED ADVISORS LLC | Director | 04/21/2011 | 12,381,667 |
| GORDON CARL L | Director | 04/20/2011 | 12,632,000 |
| GORDON CARL L | Director | 04/18/2011 | 45,549,897 |
| ORBIMED ADVISORS LLC | Director | 04/18/2011 | 428,168 |
| ORBIMED ADVISORS LLC | Director | 04/18/2011 | 45,121,729 |
| ORBIMED ADVISORS LLC | Director | 04/20/2011 | 12,632,000 |
| Zakrzewski Joseph S | Chief Executive Officer | 04/18/2011 | 815,000 |
| Zakrzewski Joseph S | Chief Executive Officer | 04/18/2011 | 4,728,210 |
| VAN HEEK G JAN | Director | 04/18/2011 | 3,090 |
| VAN HEEK G JAN | Director | 04/18/2011 | 49,530 |
| Soni Paresh | SVP and Head of Development | 04/19/2011 | 108,000 |
| Soni Paresh | SVP and Head of Development | 04/19/2011 | 1,208,624 |
| Ahlholm Frederick W | Vice President Finance | 04/20/2011 | 53,125 |
| Ahlholm Frederick W | Vice President Finance | 04/20/2011 | 496,344 |
| Abingworth LLP | 10% Owner | 04/18/2011 | 62,143,480 |
| Ahlholm Frederick W | Vice President Finance | 04/04/2011 | 53,125 |
| Ahlholm Frederick W | Vice President Finance | 04/04/2011 | 233,688 |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | 03/29/2011 | 3,080,610 |
| GORDON CARL L | Director | 03/28/2011 | 684,285 |
| GORDON CARL L | Director | 03/25/2011 | 425,043 |
| GORDON CARL L | Director | 03/24/2011 | 172,500 |
| ORBIMED ADVISORS LLC | Director | 03/25/2011 | 421,308 |
| ORBIMED ADVISORS LLC | Director | 03/24/2011 | 1,500 |
| ORBIMED ADVISORS LLC | Director | 03/24/2011 | 171,000 |
| ORBIMED ADVISORS LLC | Director | 03/28/2011 | 6,615 |
| ORBIMED ADVISORS LLC | Director | 03/28/2011 | 677,670 |
| ORBIMED ADVISORS LLC | Director | 03/25/2011 | 3,735 |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | 03/25/2011 | 563,333 |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | 03/24/2011 | 3,778,000 |
| GORDON CARL L | Director | 03/21/2011 | 542,850 |
| ORBIMED ADVISORS LLC | Director | 03/21/2011 | 4,935 |
| ORBIMED ADVISORS LLC | Director | 03/21/2011 | 537,915 |
| GORDON CARL L | Director | 03/15/2011 | 362,000 |
| GORDON CARL L | Director | 03/14/2011 | 549,750 |
| GORDON CARL L | Director | 03/11/2011 | 743,000 |
| ORBIMED ADVISORS LLC | Director | 03/14/2011 | 5,131 |
| ORBIMED ADVISORS LLC | Director | 03/14/2011 | 544,619 |
| ORBIMED ADVISORS LLC | Director | 03/11/2011 | 6,687 |
| ORBIMED ADVISORS LLC | Director | 03/11/2011 | 736,313 |
| ORBIMED ADVISORS LLC | Director | 03/15/2011 | 3,620 |
| ORBIMED ADVISORS LLC | Director | 03/15/2011 | 358,380 |
| Abingworth LLP | 10% Owner | 03/11/2011 | 20,636,001 |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | 03/11/2011 | 15,000,000 |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | 03/09/2011 | 222,575 |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | 03/10/2011 | 4,400,283 |
| Abingworth LLP | 10% Owner | 03/08/2011 | 4,125,990 |
| Zakrzewski Joseph S | Chief Executive Officer | 03/09/2011 | 13,500 |
| Abingworth LLP | 10% Owner | 03/04/2011 | 760,000 |
| GORDON CARL L | Director | 03/03/2011 | 54,320 |
| GORDON CARL L | Director | 03/07/2011 | 192,000 |
| GORDON CARL L | Director | 03/04/2011 | 327,660 |
| ORBIMED ADVISORS LLC | Director | 03/07/2011 | 1,536 |
| ORBIMED ADVISORS LLC | Director | 03/07/2011 | 190,464 |
| ORBIMED ADVISORS LLC | Director | 03/04/2011 | 3,048 |
| ORBIMED ADVISORS LLC | Director | 03/04/2011 | 324,612 |
| ORBIMED ADVISORS LLC | Director | 03/03/2011 | 776 |
| ORBIMED ADVISORS LLC | Director | 03/03/2011 | 53,544 |
| Abingworth LLP | 10% Owner | 03/02/2011 | 9,239,040 |
| ORBIMED ADVISORS LLC | Director | 02/28/2011 | 766,043 |
| ORBIMED ADVISORS LLC | Director | 03/02/2011 | 6,948 |
| ORBIMED ADVISORS LLC | Director | 03/02/2011 | 726,452 |
| ORBIMED ADVISORS LLC | Director | 03/01/2011 | 3,780 |
| ORBIMED ADVISORS LLC | Director | 03/01/2011 | 374,220 |
| ORBIMED ADVISORS LLC | Director | 02/28/2011 | 6,957 |
| GORDON CARL L | Director | 03/02/2011 | 733,400 |
| GORDON CARL L | Director | 03/01/2011 | 378,000 |
| GORDON CARL L | Director | 02/28/2011 | 773,000 |
| Abingworth LLP | 10% Owner | 03/01/2011 | 380,485 |
| Abingworth LLP | 10% Owner | 02/28/2011 | 2,178,137 |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | 02/25/2011 | 2,952,787 |
| Zakrzewski Joseph S | Chief Executive Officer | 02/25/2011 | 81,000 |
| Zakrzewski Joseph S | Chief Executive Officer | 02/25/2011 | 489,755 |
| Zakrzewski Joseph S | Chief Executive Officer | 02/22/2011 | 135,000 |
| Zakrzewski Joseph S | Chief Executive Officer | 02/22/2011 | 854,060 |
| Soni Paresh | SVP and Head of Development | 02/22/2011 | 162,000 |
| Soni Paresh | SVP and Head of Development | 02/22/2011 | 1,018,764 |
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FUNDS WITH A POSITION IN AMARIN CORP
| Fund | # Shares Owned | % of Portfolio | % Change | Investing Style |
|---|---|---|---|---|
| GEODE CAPITAL MANAGEMENT, LLC | 214,385 | 0.00002% | No change | Other |
| BLACKROCK INC. | 199,060 | 0% | -11.94% | Other |
| D. E. SHAW & CO., INC. | 56,302 | 0.00004% | -48.96% | Other |
CHANGE IN SHARES OUTSTANDING FOR AMARIN CORP
STOCK BUYBACKS FOR AMARIN CORP
Period of Report
Previous Period
% Change in Shares
10-K/10-Q Filings
Quarter
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Period of Report: 12/31/2023
10-K/10-Q Filings: View
Previous Period
% Change in Shares
Quarter
09/30/2023
-0.06%
1Q
06/30/2023
0.07%
2Q
03/31/2023
0.49%
3Q
12/31/2022
0.83%
4Q
09/30/2022
0.87%
5Q
06/30/2022
2.50%
6Q
03/31/2022
2.60%
7Q
12/31/2021
-3.48%
8Q
09/30/2021
2.91%
9Q
06/30/2021
1.59%
10Q
03/31/2021
3.42%
11Q
12/31/2020
4.46%
12Q
09/30/2020
4.74%
13Q
06/30/2020
2.12%
14Q
03/31/2020
13.02%
15Q
12/31/2019
13.58%
16Q
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BUYBACK ANNOUNCEMENT(S) FOR AMARIN CORP
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