| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Apr 02, 2026 | Option/RSU Exercise | - | 8,500 | - | 52,586 | Apr 06, 2026, 04:11 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Apr 02, 2026 | Sale | $34.71 | 3,280 | 113,849 | 49,306 | Apr 06, 2026, 04:11 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Dec 30, 2025 | Option/RSU Exercise | - | 6,000 | - | 34,650 | Jan 02, 2026, 08:18 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Dec 30, 2025 | Sale | $27.09 | 2,932 | 79,428 | 31,718 | Jan 02, 2026, 08:18 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Jun 24, 2025 | Sale | $33.54 | 2,799 | 93,878 | 28,650 | Jun 26, 2025, 05:26 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Jun 24, 2025 | Option/RSU Exercise | - | 6,000 | - | 31,449 | Jun 26, 2025, 05:26 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Mar 01, 2025 | Option/RSU Exercise | - | 13,500 | - | 27,130 | Mar 04, 2025, 04:17 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Mar 03, 2025 | Sale | $35.54 | 4,005 | 142,338 | 25,449 | Mar 04, 2025, 04:17 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Nov 07, 2024 | Sale | $52.21 | 21,752 | 1,135,775 | 24,041 | Nov 12, 2024, 04:08 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Mar 05, 2024 | Sale | $32.57 | 2,642 | 86,050 | 37,169 | Mar 05, 2024, 04:08 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Mar 01, 2024 | Option/RSU Exercise | - | 7,834 | - | 38,518 | Mar 05, 2024, 04:08 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 12, 2024 | Option/RSU Exercise | - | 1,833 | - | 32,211 | Feb 14, 2024, 05:51 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 14, 2024 | Sale | $25.14 | 545 | 13,701 | 31,666 | Feb 14, 2024, 05:51 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Jan 20, 2024 | Option/RSU Exercise | - | 5,750 | - | 32,086 | Jan 24, 2024, 04:25 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Jan 24, 2024 | Sale | $21.64 | 1,708 | 36,961 | 30,378 | Jan 24, 2024, 04:25 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Jan 05, 2024 | Option/RSU Exercise | - | 3,250 | - | 27,499 | Jan 09, 2024, 04:25 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Jan 09, 2024 | Sale | $22.99 | 1,163 | 26,737 | 26,336 | Jan 09, 2024, 04:25 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Aug 17, 2023 | Sale | $26.28 | 6,395 | 168,061 | 23,890 | Aug 21, 2023, 04:03 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Jun 28, 2023 | Option/RSU Exercise | - | 5,750 | - | 31,992 | Jun 30, 2023, 04:09 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Jun 30, 2023 | Sale | $28.36 | 1,707 | 48,411 | 30,285 | Jun 30, 2023, 04:09 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 16, 2023 | Tax Payment (Shares) | $28.91 | 609 | 17,606 | 23,538 | Feb 16, 2023, 04:04 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 14, 2023 | Option/RSU Exercise | - | 1,738 | - | 24,147 | Feb 16, 2023, 04:04 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 10, 2023 | Option/RSU Exercise | - | 1,834 | - | 23,052 | Feb 14, 2023, 04:07 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 14, 2023 | Tax Payment (Shares) | $28.44 | 643 | 18,287 | 22,409 | Feb 14, 2023, 04:07 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Dec 23, 2022 | Option/RSU Exercise | - | 8,750 | - | 23,815 | Dec 28, 2022, 04:05 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Dec 28, 2022 | Tax Payment (Shares) | $28.48 | 2,597 | 73,963 | 21,218 | Dec 28, 2022, 04:05 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 22, 2022 | Tax Payment (Shares) | $29.08 | 215 | 6,252 | 14,793 | Feb 23, 2022, 04:10 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 22, 2022 | Option/RSU Exercise | - | 724 | - | 15,008 | Feb 23, 2022, 04:10 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 14, 2022 | Tax Payment (Shares) | $30.50 | 2,155 | 65,728 | 14,284 | Feb 16, 2022, 05:01 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 14, 2022 | Option/RSU Exercise | - | 6,988 | - | 16,439 | Feb 16, 2022, 05:01 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 10, 2022 | Option/RSU Exercise | - | 1,833 | - | 10,094 | Feb 14, 2022, 04:06 PM |
| AGIO | | AGIOS PHARMACEUTICALS, INC. | James William Burns | Chief Legal Officer | Feb 10, 2022 | Tax Payment (Shares) | $31.42 | 643 | 20,206 | 9,451 | Feb 14, 2022, 04:06 PM |
