| Symbol | Company | Owner | Relationship | Date | Transaction | Cost | # Shares | Value ($) | Total Shares | Filing | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| IONS | IONIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Jun 20, 2023 | Option Exercise | $28.47 | 11,250 | 320,287 | 140,147 | Jun 22, 2023, 05:17 PM | |
| IONS | IONIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Jun 07, 2022 | Option Exercise | $12.94 | 11,250 | 145,575 | 120,899 | Jun 09, 2022, 05:53 PM | |
| IONS | IONIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Jun 23, 2021 | Sale | $23.52 | 30,000 | 705,600 | 115,983 | Jun 25, 2021, 05:19 PM | |
| IONS | IONIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Jun 23, 2020 | Sale | $33.99 | 30,000 | 1,019,700 | 111,983 | Jun 25, 2020, 07:28 PM | |
| IONS | IONIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Jun 24, 2019 | Sale | $40.00 | 30,000 | 1,199,913 | 103,784 | Jun 26, 2019, 06:52 PM | |
| IONS | IONIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Jun 25, 2018 | Option Exercise | $28.09 | 30,000 | 842,742 | 100,727 | Jun 25, 2018, 08:28 PM | |
| IONS | IONIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Feb 24, 2017 | Option Exercise | $9.77 | 12,500 | 122,125 | 88,958 | Feb 27, 2017, 07:15 PM | |
| IONS | IONIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Feb 19, 2016 | Option Exercise | $5.93 | 12,500 | 74,125 | 74,343 | Feb 22, 2016, 04:10 PM | |
| ISIS | ISIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Apr 17, 2015 | Option Exercise | $3.95 | 10,000 | 39,500 | 60,395 | Apr 17, 2015, 06:13 PM | |
| ISIS | ISIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Apr 17, 2014 | Option Exercise | $5.72 | 10,000 | 57,200 | 49,613 | Apr 17, 2014, 07:43 PM | |
| ISIS | ISIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Feb 21, 2013 | Option Exercise | $5.17 | 10,000 | 51,700 | 39,300 | Feb 22, 2013, 07:17 PM | |
| ISIS | ISIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | Jun 25, 2012 | Sale | $9.86 | 20,000 | 197,169 | 32,800 | Jun 25, 2012, 08:56 PM | |
| ISIS | ISIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | May 21, 2012 | Sale | $9.41 | 5,462 | 51,397 | 32,031 | May 22, 2012, 07:51 PM | |
| ISIS | ISIS PHARMACEUTICALS INC | BERTHELSEN SPENCER R | Director | May 22, 2012 | Sale | $9.48 | 34,538 | 327,420 | 46,569 | May 22, 2012, 07:51 PM |
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