| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| PM | Chief Life Sciences Officer | Jan 04, 2021 | Option Exercise | $81.36 | 19,570 | 1,592,117 | 19,570 | Apr 01, 2021, 04:24 PM |
| PM | Chief Life Sciences Officer | Feb 04, 2021 | Option Exercise | $81.86 | 5,120 | 419,098 | 24,690 | Feb 08, 2021, 06:13 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| PM | Chief Life Sciences Officer | Jan 04, 2021 | Option Exercise | 1,592,117 |
| PM | Chief Life Sciences Officer | Feb 04, 2021 | Option Exercise | 419,098 |