| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| ITOS | Chief Executive Officer | Apr 18, 2022 | Option Exercise | $4.23 | 11,500 | 48,645 | 37,763 | Apr 19, 2022, 07:59 PM |
| ITOS | Chief Executive Officer | Apr 18, 2022 | Sale | $31.87 | 11,500 | 366,530 | 26,296 | Apr 19, 2022, 07:59 PM |
| ITOS | Chief Executive Officer | Mar 22, 2022 | Sale | $34.17 | 18,437 | 629,987 | 38,878 | Mar 22, 2022, 08:05 PM |
| ITOS | Chief Executive Officer | Feb 23, 2022 | Sale | $34.34 | 14,500 | 497,905 | 35,244 | Feb 24, 2022, 08:00 PM |
| ITOS | Chief Executive Officer | Jan 25, 2022 | Sale | $35.68 | 14,500 | 517,378 | 53,612 | Jan 26, 2022, 07:53 PM |
| ITOS | Chief Executive Officer | Dec 22, 2021 | Option Exercise | $4.30 | 1,663 | 7,151 | 79,863 | Dec 22, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Dec 21, 2021 | Option Exercise | $4.30 | 19,226 | 82,672 | 97,426 | Dec 22, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Dec 20, 2021 | Option Exercise | $4.30 | 9,111 | 39,177 | 87,311 | Dec 22, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Dec 21, 2021 | Sale | $44.41 | 19,226 | 853,906 | 83,780 | Dec 22, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Dec 20, 2021 | Sale | $43.94 | 9,111 | 400,337 | 78,200 | Dec 22, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Dec 22, 2021 | Sale | $45.03 | 16,163 | 727,888 | 78,349 | Dec 22, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Nov 22, 2021 | Option Exercise | $12.45 | 16,263 | 202,474 | 92,700 | Nov 24, 2021, 07:59 PM |
| ITOS | Chief Executive Officer | Nov 23, 2021 | Sale | $36.08 | 14,500 | 523,160 | 78,200 | Nov 24, 2021, 07:59 PM |
| ITOS | Chief Executive Officer | Nov 03, 2021 | Sale | $28.89 | 6,085 | 175,777 | 76,437 | Nov 03, 2021, 07:59 PM |
| ITOS | Chief Executive Officer | Nov 02, 2021 | Sale | $28.42 | 14,391 | 408,920 | 82,522 | Nov 03, 2021, 07:59 PM |
| ITOS | Chief Executive Officer | Nov 01, 2021 | Sale | $28.00 | 81 | 2,268 | 96,913 | Nov 03, 2021, 07:59 PM |
| ITOS | Chief Executive Officer | Oct 21, 2021 | Sale | $28.00 | 196 | 5,488 | 96,994 | Oct 25, 2021, 08:00 PM |
| ITOS | Chief Executive Officer | Oct 19, 2021 | Sale | $28.00 | 201 | 5,628 | 97,190 | Oct 19, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Oct 15, 2021 | Sale | $28.01 | 1,635 | 45,796 | 97,391 | Oct 19, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Sep 24, 2021 | Sale | $28.02 | 1,089 | 30,512 | 99,026 | Sep 27, 2021, 08:00 PM |
| ITOS | Chief Executive Officer | Sep 23, 2021 | Sale | $28.16 | 5,322 | 149,862 | 100,115 | Sep 27, 2021, 08:00 PM |
| ITOS | Chief Executive Officer | Sep 02, 2021 | Sale | $28.94 | 11,568 | 334,796 | 105,987 | Sep 03, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Sep 01, 2021 | Sale | $28.30 | 8,684 | 245,722 | 117,005 | Sep 03, 2021, 08:01 PM |
| ITOS | Chief Executive Officer | Aug 27, 2021 | Sale | $28.17 | 8,248 | 232,346 | 132,104 | Aug 31, 2021, 08:00 PM |
| ITOS | Chief Executive Officer | Aug 31, 2021 | Sale | $28.12 | 4,093 | 115,095 | 125,689 | Aug 31, 2021, 08:00 PM |
| ITOS | Chief Executive Officer | Aug 30, 2021 | Sale | $28.01 | 2,322 | 65,039 | 129,782 | Aug 31, 2021, 08:00 PM |
| ITOS | Chief Executive Officer | Aug 25, 2021 | Sale | $28.00 | 861 | 24,109 | 140,352 | Aug 25, 2021, 08:04 PM |
| ITOS | Chief Executive Officer | Aug 24, 2021 | Sale | $28.26 | 225 | 6,359 | 141,213 | Aug 25, 2021, 08:04 PM |
| ITOS | Chief Executive Officer | Aug 23, 2021 | Sale | $28.06 | 7,499 | 210,422 | 141,438 | Aug 25, 2021, 08:04 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| ITOS | Chief Executive Officer | Apr 18, 2022 | Option Exercise | 48,645 |
| ITOS | Chief Executive Officer | Apr 18, 2022 | Sale | 366,530 |
| ITOS | Chief Executive Officer | Mar 22, 2022 | Sale | 629,987 |
| ITOS | Chief Executive Officer | Feb 23, 2022 | Sale | 497,905 |
| ITOS | Chief Executive Officer | Jan 25, 2022 | Sale | 517,378 |
| ITOS | Chief Executive Officer | Dec 22, 2021 | Option Exercise | 7,151 |
| ITOS | Chief Executive Officer | Dec 21, 2021 | Option Exercise | 82,672 |
| ITOS | Chief Executive Officer | Dec 20, 2021 | Option Exercise | 39,177 |
| ITOS | Chief Executive Officer | Dec 21, 2021 | Sale | 853,906 |
| ITOS | Chief Executive Officer | Dec 20, 2021 | Sale | 400,337 |
| ITOS | Chief Executive Officer | Dec 22, 2021 | Sale | 727,888 |
| ITOS | Chief Executive Officer | Nov 22, 2021 | Option Exercise | 202,474 |
| ITOS | Chief Executive Officer | Nov 23, 2021 | Sale | 523,160 |
| ITOS | Chief Executive Officer | Nov 03, 2021 | Sale | 175,777 |
| ITOS | Chief Executive Officer | Nov 02, 2021 | Sale | 408,920 |
| ITOS | Chief Executive Officer | Nov 01, 2021 | Sale | 2,268 |
| ITOS | Chief Executive Officer | Oct 21, 2021 | Sale | 5,488 |
| ITOS | Chief Executive Officer | Oct 19, 2021 | Sale | 5,628 |
| ITOS | Chief Executive Officer | Oct 15, 2021 | Sale | 45,796 |
| ITOS | Chief Executive Officer | Sep 24, 2021 | Sale | 30,512 |
| ITOS | Chief Executive Officer | Sep 23, 2021 | Sale | 149,862 |
| ITOS | Chief Executive Officer | Sep 02, 2021 | Sale | 334,796 |
| ITOS | Chief Executive Officer | Sep 01, 2021 | Sale | 245,722 |
| ITOS | Chief Executive Officer | Aug 27, 2021 | Sale | 232,346 |
| ITOS | Chief Executive Officer | Aug 31, 2021 | Sale | 115,095 |
| ITOS | Chief Executive Officer | Aug 30, 2021 | Sale | 65,039 |
| ITOS | Chief Executive Officer | Aug 25, 2021 | Sale | 24,109 |
| ITOS | Chief Executive Officer | Aug 24, 2021 | Sale | 6,359 |
| ITOS | Chief Executive Officer | Aug 23, 2021 | Sale | 210,422 |