| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| INZY | 10% Owner | Apr 19, 2022 | Buy | $3.69 | 1,355,000 | 4,999,950 | 4,174,379 | Apr 21, 2022, 06:04 PM |
| SRRA | 10% Owner | Feb 02, 2022 | Buy | $27.00 | 175,000 | 4,725,000 | 175,000 | Feb 02, 2022, 09:25 PM |
| SRRA | 10% Owner | Jan 25, 2022 | Option Exercise | $13.20 | 487,451 | 6,434,353 | 1,964,771 | Jan 27, 2022, 09:23 PM |
| MTEM | 10% Owner | Aug 28, 2020 | Sale | $10.75 | 3,496 | 37,568 | 0 | Sep 01, 2020, 07:33 PM |
| INZY | 10% Owner | Jul 28, 2020 | Buy | $16.00 | 625,000 | 10,000,000 | 2,819,379 | Jul 28, 2020, 06:20 PM |
| ETNB | 10% Owner | Jul 10, 2020 | Buy | $27.50 | 109,090 | 2,999,975 | 2,600,877 | Jul 14, 2020, 08:11 PM |
| MTEM | 10% Owner | Nov 25, 2019 | Buy | $8.00 | 937,500 | 7,500,000 | 4,199,035 | Dec 05, 2019, 04:16 PM |
| MTEM | 10% Owner | Nov 25, 2019 | Buy | $8.00 | 937,000 | 7,496,000 | 4,198,535 | Nov 27, 2019, 04:47 PM |
| ETNB | 10% Owner | Nov 11, 2019 | Buy | $16.00 | 575,000 | 9,200,000 | 575,000 | Nov 13, 2019, 07:02 PM |
| AXNX | 10% Owner | Nov 02, 2018 | Buy | $15.00 | 533,333 | 7,999,995 | 2,933,333 | Nov 02, 2018, 07:26 PM |
| MTEM | 10% Owner | Sep 21, 2018 | Buy | $5.50 | 365,000 | 2,007,500 | 3,261,535 | Sep 25, 2018, 04:43 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| INZY | 10% Owner | Apr 19, 2022 | Buy | 4,999,950 |
| SRRA | 10% Owner | Feb 02, 2022 | Buy | 4,725,000 |
| SRRA | 10% Owner | Jan 25, 2022 | Option Exercise | 6,434,353 |
| MTEM | 10% Owner | Aug 28, 2020 | Sale | 37,568 |
| INZY | 10% Owner | Jul 28, 2020 | Buy | 10,000,000 |
| ETNB | 10% Owner | Jul 10, 2020 | Buy | 2,999,975 |
| MTEM | 10% Owner | Nov 25, 2019 | Buy | 7,500,000 |
| MTEM | 10% Owner | Nov 25, 2019 | Buy | 7,496,000 |
| ETNB | 10% Owner | Nov 11, 2019 | Buy | 9,200,000 |
| AXNX | 10% Owner | Nov 02, 2018 | Buy | 7,999,995 |
| MTEM | 10% Owner | Sep 21, 2018 | Buy | 2,007,500 |