| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| TOCA | SVP & Chief Medical Officer | Dec 08, 2017 | Option Exercise | $8.50 | 2,500 | 21,250 | 5,000 | Dec 14, 2017, 09:10 PM |
| TOCA | SVP & Chief Medical Officer | Apr 19, 2017 | Buy | $10.00 | 2,500 | 25,000 | 2,500 | Apr 21, 2017, 05:44 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| TOCA | SVP & Chief Medical Officer | Dec 08, 2017 | Option Exercise | 21,250 |
| TOCA | SVP & Chief Medical Officer | Apr 19, 2017 | Buy | 25,000 |