| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| PYXS | Director | Dec 08, 2021 | Buy | $9.39 | 10,000 | 93,885 | 10,000 | Dec 09, 2021, 04:18 PM |
| GWPH | U.S. Chief Commercial Officer | May 28, 2020 | Option Exercise | $10.54 | 1,800 | 18,972 | 5,556 | May 29, 2020, 08:00 PM |
| GWPH | U.S. Chief Commercial Officer | May 28, 2020 | Option Exercise | $0.00 | 7,356 | 9 | 7,356 | May 29, 2020, 08:00 PM |
| GWPH | U.S. Chief Commercial Officer | May 28, 2019 | Option Exercise | $0.00 | 29,424 | 38 | 29,424 | May 30, 2019, 08:00 PM |
| SGEN | EVP, Commercial | Nov 29, 2018 | Sale | $62.88 | 7,000 | 440,160 | 72,556 | Nov 30, 2018, 06:32 PM |
| SGEN | EVP, Commercial | Nov 21, 2018 | Sale | $56.68 | 4,167 | 236,204 | 79,556 | Nov 21, 2018, 06:42 PM |
| SGEN | EVP, Commercial | Aug 27, 2018 | Sale | $74.23 | 4,784 | 355,125 | 65,079 | Aug 29, 2018, 07:32 PM |
| SGEN | EVP, Commercial | Jun 12, 2018 | Option Exercise | $29.14 | 10,086 | 293,910 | 79,831 | Jun 14, 2018, 06:31 PM |
| SGEN | EVP, Commercial | Jun 12, 2018 | Sale | $69.00 | 12,054 | 831,688 | 71,831 | Jun 14, 2018, 06:31 PM |
| SGEN | EVP, Commercial | May 09, 2018 | Option Exercise | $16.20 | 9,000 | 145,790 | 80,831 | May 11, 2018, 07:59 PM |
| SGEN | EVP, Commercial | May 09, 2018 | Sale | $55.33 | 9,000 | 497,983 | 71,831 | May 11, 2018, 07:59 PM |
| SGEN | EVP, Commercial | May 03, 2018 | Sale | $53.81 | 4,000 | 215,238 | 71,831 | May 07, 2018, 07:08 PM |
| SGEN | EVP, Commercial | Feb 05, 2018 | Option Exercise | $55.58 | 1,399 | 77,756 | 75,831 | Feb 07, 2018, 08:17 PM |
| SGEN | EVP, Commercial | Sep 06, 2017 | Option Exercise | $15.93 | 10,048 | 160,115 | 82,254 | Sep 08, 2017, 07:32 PM |
| SGEN | EVP, Commercial | Sep 06, 2017 | Sale | $51.94 | 5,024 | 260,967 | 77,230 | Sep 08, 2017, 07:32 PM |
| SGEN | EVP, Commercial | Aug 31, 2017 | Option Exercise | $18.46 | 2,907 | 53,663 | 79,775 | Sep 05, 2017, 07:23 PM |
| SGEN | EVP, Commercial | Aug 31, 2017 | Sale | $52.51 | 7,569 | 397,466 | 76,868 | Sep 05, 2017, 07:23 PM |
| SGEN | EVP, Commercial | Aug 28, 2017 | Sale | $47.89 | 1,788 | 85,635 | 76,868 | Aug 30, 2017, 07:18 PM |
| SGEN | EVP, Commercial | Aug 07, 2017 | Option Exercise | $18.46 | 6,000 | 110,760 | 67,656 | Aug 09, 2017, 06:52 PM |
| SGEN | EVP, Commercial | Aug 07, 2017 | Sale | $49.19 | 6,000 | 295,110 | 61,656 | Aug 09, 2017, 06:52 PM |
| SGEN | EVP, Commercial | Dec 16, 2016 | Option Exercise | $16.41 | 3,100 | 50,871 | 61,604 | Dec 20, 2016, 07:48 PM |
| SGEN | EVP, Commercial | Dec 13, 2016 | Option Exercise | $24.45 | 12,761 | 311,968 | 65,743 | Dec 15, 2016, 07:26 PM |
| SGEN | EVP, Commercial | Dec 13, 2016 | Sale | $63.38 | 10,000 | 633,834 | 58,504 | Dec 15, 2016, 07:26 PM |
| SGEN | EVP, Commercial | Sep 09, 2016 | Option Exercise | $15.46 | 4,167 | 64,422 | 55,743 | Sep 13, 2016, 07:09 PM |
| SGEN | EVP, Commercial | Sep 06, 2016 | Sale | $46.01 | 5,397 | 248,307 | 52,347 | Sep 08, 2016, 07:18 PM |
| SGEN | EVP, Commercial | Aug 22, 2016 | Sale | $46.59 | 1,774 | 82,652 | 40,973 | Aug 22, 2016, 09:38 PM |
| SGEN | SVP, Commercial | Aug 20, 2015 | Sale | $42.02 | 2,231 | 93,757 | 31,482 | Aug 22, 2016, 09:19 PM |
| SGEN | EVP, Commercial | Jun 02, 2016 | Sale | $42.07 | 3,366 | 141,617 | 42,747 | Jun 06, 2016, 06:52 PM |
| SGEN | SVP, Commercial | Nov 11, 2015 | Sale | $45.68 | 5,769 | 263,548 | 37,713 | Nov 13, 2015, 05:49 PM |
| SGEN | SVP, Commercial | Aug 20, 2015 | Sale | $42.02 | 2,231 | 93,757 | 31,482 | Aug 25, 2015, 08:46 PM |
| SGEN | SVP, Commercial | Mar 13, 2015 | Sale | $38.65 | 7,500 | 289,876 | 33,135 | Mar 17, 2015, 07:10 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| PYXS | Director | Dec 08, 2021 | Buy | 93,885 |
| GWPH | U.S. Chief Commercial Officer | May 28, 2020 | Option Exercise | 18,972 |
| GWPH | U.S. Chief Commercial Officer | May 28, 2020 | Option Exercise | 9 |
| GWPH | U.S. Chief Commercial Officer | May 28, 2019 | Option Exercise | 38 |
| SGEN | EVP, Commercial | Nov 29, 2018 | Sale | 440,160 |
| SGEN | EVP, Commercial | Nov 21, 2018 | Sale | 236,204 |
| SGEN | EVP, Commercial | Aug 27, 2018 | Sale | 355,125 |
| SGEN | EVP, Commercial | Jun 12, 2018 | Option Exercise | 293,910 |
| SGEN | EVP, Commercial | Jun 12, 2018 | Sale | 831,688 |
| SGEN | EVP, Commercial | May 09, 2018 | Option Exercise | 145,790 |
| SGEN | EVP, Commercial | May 09, 2018 | Sale | 497,983 |
| SGEN | EVP, Commercial | May 03, 2018 | Sale | 215,238 |
| SGEN | EVP, Commercial | Feb 05, 2018 | Option Exercise | 77,756 |
| SGEN | EVP, Commercial | Sep 06, 2017 | Option Exercise | 160,115 |
| SGEN | EVP, Commercial | Sep 06, 2017 | Sale | 260,967 |
| SGEN | EVP, Commercial | Aug 31, 2017 | Option Exercise | 53,663 |
| SGEN | EVP, Commercial | Aug 31, 2017 | Sale | 397,466 |
| SGEN | EVP, Commercial | Aug 28, 2017 | Sale | 85,635 |
| SGEN | EVP, Commercial | Aug 07, 2017 | Option Exercise | 110,760 |
| SGEN | EVP, Commercial | Aug 07, 2017 | Sale | 295,110 |
| SGEN | EVP, Commercial | Dec 16, 2016 | Option Exercise | 50,871 |
| SGEN | EVP, Commercial | Dec 13, 2016 | Option Exercise | 311,968 |
| SGEN | EVP, Commercial | Dec 13, 2016 | Sale | 633,834 |
| SGEN | EVP, Commercial | Sep 09, 2016 | Option Exercise | 64,422 |
| SGEN | EVP, Commercial | Sep 06, 2016 | Sale | 248,307 |
| SGEN | EVP, Commercial | Aug 22, 2016 | Sale | 82,652 |
| SGEN | SVP, Commercial | Aug 20, 2015 | Sale | 93,757 |
| SGEN | EVP, Commercial | Jun 02, 2016 | Sale | 141,617 |
| SGEN | SVP, Commercial | Nov 11, 2015 | Sale | 263,548 |
| SGEN | SVP, Commercial | Aug 20, 2015 | Sale | 93,757 |
| SGEN | SVP, Commercial | Mar 13, 2015 | Sale | 289,876 |