| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| AGP | EVP, Chief Medical Officer | Dec 24, 2012 |
Option Exercise | $92.00 | 39,161 | 3,602,812 | 0 | Dec 27, 2012, 02:11 PM |
| AGP | EVP, Chief Medical Officer | Nov 26, 2012 |
Option Exercise | $91.59 | 2,403 | 220,091 | 36,980 | Nov 28, 2012, 01:14 PM |
| AGP | EVP, Chief Medical Officer | Jul 09, 2012 |
Option Exercise | $34.16 | 7,409 | 253,068 | 46,792 | Jul 11, 2012, 11:59 AM |
| AGP | EVP, Chief Medical Officer | Jul 09, 2012 |
Sale | $88.75 | 7,409 | 657,549 | 39,383 | Jul 11, 2012, 11:59 AM |
| AGP | EVP, Chief Medical Officer | Apr 30, 2012 |
Option Exercise | $61.76 | 868 | 53,608 | 39,383 | May 08, 2012, 10:16 AM |
| AGP | EVP, Chief Medical Officer | Apr 30, 2012 |
Option Exercise | $61.76 | 703 | 43,417 | 39,548 | May 02, 2012, 02:46 PM |
| AGP | EVP, Chief Medical Officer | Mar 12, 2012 |
Option Exercise | $64.97 | 50 | 3,249 | 38,059 | Mar 14, 2012, 02:07 PM |
| AGP | EVP, Chief Medical Officer | Jan 07, 2012 |
Option Exercise | $65.07 | 143 | 9,305 | 38,109 | Jan 10, 2012, 03:06 PM |
| AGP | EVP, Chief Medical Officer | Dec 01, 2011 |
Option Exercise | $56.96 | 2,403 | 136,875 | 38,252 | Dec 05, 2011, 10:16 AM |
| AGP | EVP, Chief Medical Officer | Apr 30, 2011 |
Option Exercise | $68.30 | 652 | 44,532 | 37,334 | May 10, 2011, 01:26 PM |
| AGP | EVP, Chief Medical Officer | May 04, 2011 |
Option Exercise | $34.06 | 22,799 | 776,423 | 60,350 | May 05, 2011, 05:23 PM |
| AGP | EVP, Chief Medical Officer | May 03, 2011 |
Option Exercise | $34.41 | 9,303 | 320,083 | 46,854 | May 05, 2011, 05:23 PM |
| AGP | EVP, Chief Medical Officer | May 04, 2011 |
Sale | $66.21 | 22,799 | 1,509,425 | 59,994 | May 05, 2011, 05:23 PM |
| AGP | EVP, Chief Medical Officer | May 03, 2011 |
Sale | $67.19 | 9,303 | 625,092 | 45,988 | May 05, 2011, 05:23 PM |
| AGP | EVP, Chief Medical Officer | Apr 30, 2011 |
Option Exercise | $68.30 | 435 | 29,711 | 37,551 | May 03, 2011, 03:46 PM |
| AGP | EVP, Chief Medical Officer | Mar 12, 2011 |
Option Exercise | $58.98 | 50 | 2,949 | 37,986 | Mar 15, 2011, 02:14 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| AGP | EVP, Chief Medical Officer | Dec 24, 2012 |
Option Exercise | 3,602,812 |
| AGP | EVP, Chief Medical Officer | Nov 26, 2012 |
Option Exercise | 220,091 |
| AGP | EVP, Chief Medical Officer | Jul 09, 2012 |
Option Exercise | 253,068 |
| AGP | EVP, Chief Medical Officer | Jul 09, 2012 |
Sale | 657,549 |
| AGP | EVP, Chief Medical Officer | Apr 30, 2012 |
Option Exercise | 53,608 |
| AGP | EVP, Chief Medical Officer | Apr 30, 2012 |
Option Exercise | 43,417 |
| AGP | EVP, Chief Medical Officer | Mar 12, 2012 |
Option Exercise | 3,249 |
| AGP | EVP, Chief Medical Officer | Jan 07, 2012 |
Option Exercise | 9,305 |
| AGP | EVP, Chief Medical Officer | Dec 01, 2011 |
Option Exercise | 136,875 |
| AGP | EVP, Chief Medical Officer | Apr 30, 2011 |
Option Exercise | 44,532 |
| AGP | EVP, Chief Medical Officer | May 04, 2011 |
Option Exercise | 776,423 |
| AGP | EVP, Chief Medical Officer | May 03, 2011 |
Option Exercise | 320,083 |
| AGP | EVP, Chief Medical Officer | May 04, 2011 |
Sale | 1,509,425 |
| AGP | EVP, Chief Medical Officer | May 03, 2011 |
Sale | 625,092 |
| AGP | EVP, Chief Medical Officer | Apr 30, 2011 |
Option Exercise | 29,711 |
| AGP | EVP, Chief Medical Officer | Mar 12, 2011 |
Option Exercise | 2,949 |
