| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| CNST | 10% Owner | Aug 22, 2018 | Option Exercise | $1.55 | 51,032 | 79,100 | 3,034,083 | Aug 24, 2018, 04:05 PM |
| CNST | 10% Owner | Jul 23, 2018 | Buy | $15.00 | 266,667 | 4,000,005 | 2,983,051 | Jul 24, 2018, 07:19 PM |
| CTMX | 10% Owner | Mar 27, 2017 | Sale | $18.00 | 650,000 | 11,700,195 | 5,170,348 | Mar 27, 2017, 07:28 PM |
| CTMX | 10% Owner | Mar 23, 2017 | Sale | $17.00 | 1,000,000 | 17,000,200 | 5,820,348 | Mar 27, 2017, 07:28 PM |
| FMI | 10% Owner | Apr 07, 2015 | Sale | $50.00 | 4,098,778 | 204,938,900 | 828,456 | Apr 16, 2015, 11:15 AM |
| FMI | 10% Owner | Apr 07, 2015 | Sale | $50.00 | 3,976,278 | 198,813,900 | 950,956 | Apr 09, 2015, 04:41 PM |
| BLUE | 10% Owner | Sep 12, 2014 | Sale | $36.59 | 38,000 | 1,390,420 | 1,215,054 | Sep 12, 2014, 04:07 PM |
| BLUE | 10% Owner | Sep 11, 2014 | Sale | $36.52 | 87,000 | 3,177,240 | 2,329,974 | Sep 12, 2014, 04:07 PM |
| EBIO | 10% Owner | Feb 11, 2014 | Option Exercise | $0.06 | 127,077 | 8,069 | 4,207,120 | Feb 13, 2014, 02:27 PM |
| BLUE | 10% Owner | Jan 21, 2014 | Sale | $23.91 | 250,000 | 5,977,500 | 2,416,974 | Jan 23, 2014, 05:06 PM |
| BLUE | 10% Owner | Jan 15, 2014 | Sale | $22.14 | 260,000 | 5,756,400 | 2,713,974 | Jan 17, 2014, 05:12 PM |
| BLUE | 10% Owner | Jan 17, 2014 | Sale | $23.96 | 14,000 | 335,440 | 2,666,974 | Jan 17, 2014, 05:12 PM |
| BLUE | 10% Owner | Jan 16, 2014 | Sale | $24.02 | 33,000 | 792,660 | 2,680,974 | Jan 17, 2014, 05:12 PM |
| BLUE | 10% Owner | Jan 14, 2014 | Sale | $21.91 | 270,000 | 5,915,700 | 2,973,974 | Jan 14, 2014, 07:27 PM |
| BLUE | 10% Owner | Jan 13, 2014 | Sale | $21.80 | 45,000 | 981,000 | 3,243,974 | Jan 14, 2014, 07:27 PM |
| BLUE | 10% Owner | Jan 10, 2014 | Sale | $21.98 | 25,000 | 549,500 | 3,288,974 | Jan 14, 2014, 07:27 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| CNST | 10% Owner | Aug 22, 2018 | Option Exercise | 79,100 |
| CNST | 10% Owner | Jul 23, 2018 | Buy | 4,000,005 |
| CTMX | 10% Owner | Mar 27, 2017 | Sale | 11,700,195 |
| CTMX | 10% Owner | Mar 23, 2017 | Sale | 17,000,200 |
| FMI | 10% Owner | Apr 07, 2015 | Sale | 204,938,900 |
| FMI | 10% Owner | Apr 07, 2015 | Sale | 198,813,900 |
| BLUE | 10% Owner | Sep 12, 2014 | Sale | 1,390,420 |
| BLUE | 10% Owner | Sep 11, 2014 | Sale | 3,177,240 |
| EBIO | 10% Owner | Feb 11, 2014 | Option Exercise | 8,069 |
| BLUE | 10% Owner | Jan 21, 2014 | Sale | 5,977,500 |
| BLUE | 10% Owner | Jan 15, 2014 | Sale | 5,756,400 |
| BLUE | 10% Owner | Jan 17, 2014 | Sale | 335,440 |
| BLUE | 10% Owner | Jan 16, 2014 | Sale | 792,660 |
| BLUE | 10% Owner | Jan 14, 2014 | Sale | 5,915,700 |
| BLUE | 10% Owner | Jan 13, 2014 | Sale | 981,000 |
| BLUE | 10% Owner | Jan 10, 2014 | Sale | 549,500 |