| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 25, 2025 | Sale | $80.00 | 12,000 | 960,000 | 0 | Nov 28, 2025, 05:51 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 25, 2025 | Option/RSU Exercise | - | 12,000 | - | 4,000 | Nov 28, 2025, 05:51 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Sep 03, 2025 | Option/RSU Exercise | - | 28,000 | - | 28,000 | Sep 04, 2025, 08:38 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Sep 03, 2025 | Sale | $60.00 | 28,000 | 1,680,000 | 0 | Sep 04, 2025, 08:38 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Sep 03, 2025 | Option/RSU Exercise | - | 28,000 | - | 28,000 | Sep 04, 2025, 08:37 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Sep 03, 2025 | Sale | $60.00 | 28,000 | 1,680,000 | 0 | Sep 04, 2025, 08:37 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 16, 2024 | Option/RSU Exercise | $24.42 | 12,000 | 293,040 | 12,000 | Jul 17, 2024, 05:02 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 16, 2024 | Sale | $50.00 | 12,000 | 600,000 | 0 | Jul 17, 2024, 05:02 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | May 03, 2024 | Sale | $42.71 | 6,000 | 256,277 | 4,682 | May 07, 2024, 04:55 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 15, 2023 | Sale | $50.00 | 2,000 | 100,000 | 16,346 | Nov 17, 2023, 04:58 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Sep 26, 2023 | Sale | $45.13 | 2,000 | 90,254 | 18,346 | Sep 28, 2023, 06:03 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 18, 2023 | Sale | $42.00 | 3,555 | 149,310 | 20,346 | Jul 19, 2023, 06:05 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 17, 2023 | Option/RSU Exercise | - | 7,110 | - | 23,901 | Jul 19, 2023, 06:05 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jan 17, 2023 | Sale | $40.00 | 2,000 | 80,000 | 16,791 | Jan 18, 2023, 08:19 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 15, 2022 | Option/RSU Exercise | - | 7,998 | - | 20,124 | Jul 19, 2022, 07:20 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 15, 2022 | Sale | $38.24 | 1,333 | 50,977 | 19,435 | Jul 19, 2022, 07:20 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 15, 2021 | Sale | $35.30 | 4,334 | 152,989 | 18,126 | Jul 19, 2021, 08:14 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 15, 2021 | Option/RSU Exercise | - | 8,666 | - | 22,460 | Jul 19, 2021, 08:14 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Oct 20, 2020 | Sale | $46.86 | 2,889 | 135,386 | 13,794 | Oct 22, 2020, 05:36 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 01, 2020 | Option/RSU Exercise | - | 2,444 | - | 15,127 | Jul 06, 2020, 05:32 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 02, 2020 | Option/RSU Exercise | - | 889 | - | 16,016 | Jul 06, 2020, 05:32 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 06, 2020 | Option/RSU Exercise | - | 667 | - | 16,683 | Jul 06, 2020, 05:32 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 23, 2019 | Option/RSU Exercise | $35.53 | 1,000 | 35,530 | 13,683 | Dec 23, 2019, 07:28 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 23, 2019 | Sale | $61.87 | 1,000 | 61,874 | 12,683 | Dec 23, 2019, 07:28 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 16, 2019 | Option/RSU Exercise | $35.53 | 1,000 | 35,530 | 13,683 | Dec 18, 2019, 05:07 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 16, 2019 | Sale | $65.45 | 1,000 | 65,447 | 12,683 | Dec 18, 2019, 05:07 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 09, 2019 | Option/RSU Exercise | $35.53 | 1,000 | 35,530 | 13,683 | Dec 10, 2019, 06:54 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 09, 2019 | Sale | $63.74 | 1,000 | 63,745 | 12,683 | Dec 10, 2019, 06:54 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 02, 2019 | Option/RSU Exercise | $35.53 | 1,000 | 35,530 | 13,683 | Dec 04, 2019, 06:26 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 02, 2019 | Sale | $64.08 | 1,000 | 64,083 | 12,683 | Dec 04, 2019, 06:26 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 25, 2019 | Sale | $62.90 | 812 | 51,075 | 12,683 | Nov 26, 2019, 05:43 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 20, 2019 | Sale | $60.00 | 2,000 | 120,000 | 13,495 | Nov 21, 2019, 06:40 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 03, 2019 | Option/RSU Exercise | - | 667 | - | 15,495 | Jul 03, 2019, 06:46 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 01, 2019 | Option/RSU Exercise | - | 1,333 | - | 13,939 | Jul 03, 2019, 06:46 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 02, 2019 | Option/RSU Exercise | - | 889 | - | 14,828 | Jul 03, 2019, 06:46 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 01, 2018 | Option/RSU Exercise | - | 2,000 | - | 11,939 | Jul 03, 2018, 03:07 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 03, 2018 | Option/RSU Exercise | - | 667 | - | 12,606 | Jul 03, 2018, 03:07 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 29, 2018 | Sale | $46.15 | 2,000 | 92,300 | 9,939 | Mar 30, 2018, 03:51 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 29, 2018 | Option/RSU Exercise | $24.42 | 2,000 | 48,840 | 11,939 | Mar 30, 2018, 03:51 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 15, 2018 | Option/RSU Exercise | $24.42 | 2,000 | 48,840 | 10,839 | Mar 16, 2018, 04:19 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 15, 2018 | Sale | $51.13 | 2,000 | 102,258 | 9,939 | Mar 16, 2018, 04:19 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Feb 28, 2018 | Sale | $51.91 | 3,000 | 155,727 | 9,939 | Mar 01, 2018, 05:52 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Feb 28, 2018 | Option/RSU Exercise | $35.53 | 3,000 | 106,590 | 12,039 | Mar 01, 2018, 05:52 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Feb 15, 2018 | Option/RSU Exercise | $35.53 | 3,000 | 106,590 | 11,539 | Feb 16, 2018, 06:00 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Feb 15, 2018 | Sale | $48.99 | 3,000 | 146,984 | 9,939 | Feb 16, 2018, 06:00 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jan 30, 2018 | Sale | $52.86 | 3,000 | 158,580 | 9,939 | Jan 31, 2018, 04:18 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jan 30, 2018 | Option/RSU Exercise | $35.53 | 3,000 | 106,590 | 12,939 | Jan 31, 2018, 04:18 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jan 16, 2018 | Option/RSU Exercise | $35.53 | 3,000 | 106,590 | 11,539 | Jan 17, 2018, 09:28 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jan 16, 2018 | Sale | $52.52 | 3,000 | 157,566 | 9,939 | Jan 17, 2018, 09:28 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 29, 2017 | Option/RSU Exercise | $28.47 | 3,000 | 85,410 | 12,939 | Jan 02, 2018, 05:50 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 29, 2017 | Sale | $50.56 | 3,000 | 151,680 | 9,939 | Jan 02, 2018, 05:50 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 15, 2017 | Option/RSU Exercise | $28.47 | 3,000 | 85,410 | 12,939 | Dec 19, 2017, 08:27 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Dec 15, 2017 | Sale | $51.69 | 3,000 | 155,070 | 9,939 | Dec 19, 2017, 08:27 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 30, 2017 | Option/RSU Exercise | $28.47 | 3,000 | 85,410 | 12,939 | Dec 01, 2017, 07:04 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 30, 2017 | Sale | $53.55 | 3,000 | 160,650 | 9,939 | Dec 01, 2017, 07:04 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 16, 2017 | Option/RSU Exercise | $12.94 | 2,812 | 36,387 | 9,939 | Nov 17, 2017, 05:57 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 15, 2017 | Option/RSU Exercise | $28.47 | 2,250 | 64,057 | 9,377 | Nov 17, 2017, 05:57 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 15, 2017 | Sale | $53.56 | 2,250 | 120,510 | 7,127 | Nov 17, 2017, 05:57 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 13, 2017 | Sale | $55.39 | 3,000 | 166,170 | 7,127 | Nov 14, 2017, 06:29 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 02, 2017 | Option/RSU Exercise | - | 2,469 | - | 10,127 | Jul 03, 2017, 05:31 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 01, 2016 | Option/RSU Exercise | - | 1,803 | - | 7,346 | Jul 06, 2016, 06:37 PM |
| IONS | | IONIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 02, 2016 | Option/RSU Exercise | - | 312 | - | 7,658 | Jul 06, 2016, 06:37 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 11, 2015 | Option/RSU Exercise | $10.95 | 6,875 | 75,312 | 9,293 | Nov 12, 2015, 07:02 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 11, 2015 | Sale | $64.18 | 6,875 | 441,234 | 5,543 | Nov 12, 2015, 07:02 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 01, 2015 | Option/RSU Exercise | - | 1,136 | - | 5,231 | Jul 02, 2015, 05:58 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 02, 2015 | Option/RSU Exercise | - | 312 | - | 5,543 | Jul 02, 2015, 05:58 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 05, 2015 | Sale | $70.95 | 7,000 | 496,681 | 4,095 | Mar 09, 2015, 07:25 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 05, 2015 | Option/RSU Exercise | $10.18 | 10,000 | 101,800 | 11,095 | Mar 09, 2015, 07:25 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Feb 11, 2015 | Gift | - | 2,000 | - | 1,095 | Feb 13, 2015, 05:50 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 01, 2014 | Option/RSU Exercise | - | 469 | - | 2,782 | Jul 02, 2014, 12:18 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 02, 2014 | Option/RSU Exercise | - | 313 | - | 3,095 | Jul 02, 2014, 12:18 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jan 24, 2014 | Sale | $48.66 | 10,313 | 501,838 | 2,313 | Jan 24, 2014, 08:26 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jan 24, 2014 | Option/RSU Exercise | $15.40 | 10,313 | 158,800 | 9,813 | Jan 24, 2014, 08:26 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Nov 25, 2013 | Sale | $36.86 | 6,000 | 221,156 | 2,313 | Nov 27, 2013, 04:40 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Aug 09, 2013 | Option/RSU Exercise | $10.18 | 18,750 | 190,950 | 15,813 | Aug 13, 2013, 07:45 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Aug 09, 2013 | Sale | $28.22 | 18,750 | 529,126 | 8,313 | Aug 13, 2013, 07:45 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Jul 02, 2013 | Option/RSU Exercise | - | 313 | - | 8,313 | Jul 03, 2013, 06:51 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 20, 2013 | Sale | $18.00 | 3,924 | 70,632 | 0 | Mar 21, 2013, 08:25 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 20, 2013 | Option/RSU Exercise | $13.60 | 3,924 | 53,357 | 2,500 | Mar 21, 2013, 08:25 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 20, 2013 | Option/RSU Exercise | $12.34 | 11,841 | 146,118 | 4,167 | Mar 21, 2013, 08:24 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 20, 2013 | Sale | $18.00 | 11,841 | 213,138 | 0 | Mar 21, 2013, 08:24 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 19, 2013 | Option/RSU Exercise | $5.93 | 3,726 | 22,095 | 3,726 | Mar 21, 2013, 08:24 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 20, 2013 | Option/RSU Exercise | $12.09 | 19,756 | 238,864 | 4,266 | Mar 21, 2013, 08:24 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 19, 2013 | Sale | $18.00 | 3,726 | 67,068 | 0 | Mar 21, 2013, 08:24 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 20, 2013 | Sale | $18.00 | 19,756 | 355,608 | 100 | Mar 21, 2013, 08:24 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 19, 2013 | Option/RSU Exercise | $5.93 | 7,453 | 44,196 | 3,826 | Mar 21, 2013, 08:24 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 19, 2013 | Sale | $18.00 | 7,453 | 134,154 | 100 | Mar 21, 2013, 08:24 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 13, 2013 | Sale | $18.01 | 13,867 | 249,702 | 100 | Mar 14, 2013, 09:00 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 13, 2013 | Option/RSU Exercise | $5.20 | 6,933 | 36,046 | 6,667 | Mar 14, 2013, 09:00 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 13, 2013 | Sale | $18.01 | 6,933 | 124,842 | 0 | Mar 14, 2013, 09:00 PM |
| ISIS | | ISIS PHARMACEUTICALS INC | Joseph Klein III | Director | Mar 13, 2013 | Option/RSU Exercise | $5.20 | 13,867 | 72,098 | 6,766 | Mar 14, 2013, 09:00 PM |