| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| O'Neill Gilmore Neil | EVP, R&D & CMO | May 24, 2019 | Option Exercise | $119.31 | 4,630 | 552,405 | 7,370 | May 24, 2019, 08:07 PM |
| Wigzell Hans Lennart Rudolf | Director | May 23, 2019 | Option Exercise | $7.80 | 10,000 | 78,000 | 21,717 | May 24, 2019, 08:03 PM |
| Wigzell Hans Lennart Rudolf | Director | May 23, 2019 | Sale | $120.00 | 10,000 | 1,200,000 | 11,717 | May 24, 2019, 08:03 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 28, 2019 | Option Exercise | $118.68 | 2,953 | 350,462 | 20,425 | Mar 29, 2019, 08:01 PM |
| Howton David T | EVP, General Counsel | Mar 28, 2019 | Option Exercise | $118.68 | 2,362 | 280,322 | 18,703 | Mar 29, 2019, 08:00 PM |
| Cumbo Alexander | EVP, Chief Commercial Officer | Mar 28, 2019 | Option Exercise | $118.68 | 2,165 | 256,942 | 11,161 | Mar 29, 2019, 07:59 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 19, 2019 | Option Exercise | $126.47 | 2,625 | 331,984 | 16,729 | Mar 20, 2019, 08:00 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 19, 2019 | Option Exercise | $21.46 | 15,486 | 332,308 | 19,354 | Mar 20, 2019, 08:00 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Feb 07, 2019 | Option Exercise | $23.85 | 65,000 | 1,550,250 | 73,649 | Feb 08, 2019, 08:02 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Feb 07, 2019 | Sale | $145.00 | 65,000 | 9,425,000 | 8,649 | Feb 08, 2019, 08:02 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Feb 01, 2019 | Option Exercise | $22.54 | 7,500 | 169,035 | 30,266 | Feb 01, 2019, 08:27 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Feb 01, 2019 | Sale | $140.00 | 15,000 | 2,100,000 | 15,266 | Feb 01, 2019, 08:27 PM |
| Howton David T | SVP, General Counsel | Feb 01, 2019 | Option Exercise | $21.65 | 21,500 | 465,391 | 49,571 | Feb 01, 2019, 08:25 PM |
| Howton David T | SVP, General Counsel | Feb 01, 2019 | Sale | $140.00 | 30,000 | 4,200,000 | 19,571 | Feb 01, 2019, 08:25 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Jan 31, 2019 | Option Exercise | $23.85 | 21,198 | 505,572 | 29,847 | Feb 01, 2019, 08:24 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Jan 30, 2019 | Option Exercise | $18.27 | 43,802 | 800,077 | 52,451 | Feb 01, 2019, 08:24 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Jan 31, 2019 | Sale | $130.72 | 21,198 | 2,771,003 | 8,649 | Feb 01, 2019, 08:24 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Jan 30, 2019 | Sale | $130.00 | 43,802 | 5,694,260 | 8,649 | Feb 01, 2019, 08:24 PM |
| Wigzell Hans Lennart Rudolf | Director | Nov 01, 2018 | Option Exercise | $8.94 | 6,667 | 59,603 | 16,751 | Nov 02, 2018, 06:01 PM |
| Wigzell Hans Lennart Rudolf | Director | Nov 01, 2018 | Sale | $140.50 | 6,667 | 936,714 | 10,084 | Nov 02, 2018, 06:01 PM |
| BEHRENS M KATHLEEN | Director | Oct 31, 2018 | Option Exercise | $3.96 | 10,000 | 39,600 | 126,534 | Nov 02, 2018, 06:00 PM |
| BEHRENS M KATHLEEN | Director | Oct 31, 2018 | Sale | $131.71 | 10,000 | 1,317,100 | 116,534 | Nov 02, 2018, 06:00 PM |
| INGRAM DOUGLAS S | President & CEO | Oct 30, 2018 | Buy | $120.39 | 16,695 | 2,009,872 | 415,945 | Oct 30, 2018, 07:05 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Oct 24, 2018 | Option Exercise | $14.88 | 89,400 | 1,330,389 | 128,185 | Oct 26, 2018, 06:43 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Oct 24, 2018 | Sale | $127.74 | 107,524 | 13,735,116 | 20,661 | Oct 26, 2018, 06:43 PM |
| INGRAM DOUGLAS S | President & CEO | Aug 15, 2018 | Buy | $125.26 | 16,000 | 2,004,208 | 399,250 | Aug 16, 2018, 07:30 AM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Aug 08, 2018 | Option Exercise | $121.02 | 6,000 | 726,120 | 22,766 | Aug 08, 2018, 06:16 PM |
| Howton David T | SVP, General Counsel | Aug 08, 2018 | Option Exercise | $121.02 | 6,800 | 822,936 | 28,071 | Aug 08, 2018, 06:14 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Aug 08, 2018 | Option Exercise | $121.02 | 8,501 | 1,028,791 | 38,785 | Aug 08, 2018, 06:14 PM |
| Howton David T | SVP, General Counsel | Jul 16, 2018 | Option Exercise | $13.85 | 50,000 | 692,691 | 72,719 | Jul 17, 2018, 06:01 PM |
| Howton David T | SVP, General Counsel | Jul 16, 2018 | Sale | $136.46 | 50,000 | 6,823,000 | 34,871 | Jul 17, 2018, 06:01 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Jul 09, 2018 | Option Exercise | $13.78 | 33,782 | 465,415 | 40,690 | Jul 11, 2018, 06:05 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Jul 09, 2018 | Sale | $137.32 | 33,782 | 4,638,944 | 28,766 | Jul 11, 2018, 06:05 PM |
| Barry Richard | Director | Jun 27, 2018 | Sale | $130.34 | 75,000 | 9,775,500 | 3,170,432 | Jun 29, 2018, 06:01 PM |
| INGRAM DOUGLAS S | President & CEO | Jun 26, 2018 | Option Exercise | $135.53 | 36,946 | 5,007,291 | 383,250 | Jun 27, 2018, 05:24 PM |
| Ruff Shamim | SVP, Chief Regulatory Affairs | May 22, 2018 | Option Exercise | $89.22 | 1,305 | 116,432 | 31,936 | May 24, 2018, 06:06 PM |
| Mahatme Sandesh | EVP, CFO & CBO | May 22, 2018 | Option Exercise | $89.22 | 2,024 | 180,581 | 47,286 | May 24, 2018, 06:05 PM |
| Howton David T | SVP, General Counsel | May 22, 2018 | Option Exercise | $89.22 | 1,566 | 139,719 | 34,871 | May 24, 2018, 06:05 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | May 22, 2018 | Option Exercise | $89.22 | 1,435 | 128,031 | 28,766 | May 24, 2018, 06:04 PM |
| Ruff Shamim | SVP, Chief Regulatory Affairs | Mar 15, 2018 | Option Exercise | $81.22 | 736 | 59,778 | 28,809 | Mar 16, 2018, 06:13 PM |
| Ruff Shamim | SVP, Chief Regulatory Affairs | Mar 15, 2018 | Option Exercise | $23.93 | 2,500 | 59,813 | 29,465 | Mar 16, 2018, 06:13 PM |
| Howton David T | SVP, General Counsel | Mar 15, 2018 | Option Exercise | $81.22 | 680 | 55,230 | 31,118 | Mar 16, 2018, 06:12 PM |
| Howton David T | SVP, General Counsel | Mar 15, 2018 | Option Exercise | $22.15 | 2,500 | 55,382 | 31,727 | Mar 16, 2018, 06:12 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Mar 15, 2018 | Option Exercise | $81.22 | 633 | 51,412 | 25,325 | Mar 16, 2018, 06:10 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Mar 15, 2018 | Option Exercise | $20.64 | 2,500 | 51,600 | 25,767 | Mar 16, 2018, 06:10 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 15, 2018 | Option Exercise | $81.22 | 734 | 59,615 | 42,661 | Mar 16, 2018, 06:08 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 15, 2018 | Option Exercise | $23.85 | 2,500 | 59,625 | 43,395 | Mar 16, 2018, 06:08 PM |
| Wigzell Hans Lennart Rudolf | Director | Nov 30, 2017 | Option Exercise | $7.38 | 6,667 | 49,202 | 13,333 | Dec 04, 2017, 08:00 PM |
| Wigzell Hans Lennart Rudolf | Director | Nov 30, 2017 | Sale | $55.89 | 6,667 | 372,619 | 6,666 | Dec 04, 2017, 08:00 PM |
| INGRAM DOUGLAS S | President & CEO | Nov 08, 2017 | Buy | $52.44 | 38,138 | 1,999,957 | 420,196 | Nov 13, 2017, 05:00 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Nov 06, 2017 | Option Exercise | $14.76 | 10,000 | 147,600 | 37,045 | Nov 08, 2017, 08:13 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Nov 06, 2017 | Sale | $55.00 | 10,000 | 550,000 | 27,045 | Nov 08, 2017, 08:13 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Oct 03, 2017 | Option Exercise | $14.76 | 11,500 | 169,740 | 38,545 | Oct 05, 2017, 07:24 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Oct 03, 2017 | Sale | $50.00 | 11,500 | 575,000 | 27,045 | Oct 05, 2017, 07:24 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Aug 03, 2017 | Option Exercise | $37.88 | 2,882 | 109,170 | 27,045 | Aug 07, 2017, 04:44 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Aug 03, 2017 | Option Exercise | $37.88 | 6,264 | 237,280 | 40,895 | Aug 07, 2017, 04:42 PM |
| Howton David T | SVP, General Counsel | Aug 03, 2017 | Option Exercise | $37.88 | 4,642 | 175,839 | 29,298 | Aug 07, 2017, 04:40 PM |
| Kaye Edward M. MD | Director | Aug 03, 2017 | Option Exercise | $37.88 | 16,703 | 632,710 | 71,229 | Aug 07, 2017, 04:39 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Aug 03, 2017 | Option Exercise | $37.88 | 3,169 | 120,042 | 23,458 | Aug 07, 2017, 04:38 PM |
| INGRAM DOUGLAS S | President & CEO | Jul 27, 2017 | Buy | $42.50 | 47,058 | 1,999,965 | 382,058 | Jul 28, 2017, 08:51 AM |
| Mahatme Sandesh | EVP, CFO & CBO | Jul 20, 2017 | Option Exercise | $15.38 | 50,000 | 769,107 | 65,359 | Jul 21, 2017, 09:49 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Jul 21, 2017 | Option Exercise | $23.85 | 1,500 | 35,775 | 33,861 | Jul 21, 2017, 09:49 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Jul 20, 2017 | Sale | $41.00 | 50,000 | 2,050,000 | 32,361 | Jul 21, 2017, 09:49 PM |
| Kaye Edward M. MD | Director | Jul 20, 2017 | Option Exercise | $40.93 | 4,349 | 178,005 | 62,471 | Jul 21, 2017, 09:48 PM |
| Kaye Edward M. MD | Director | Jul 20, 2017 | Sale | $41.00 | 10,000 | 410,000 | 52,471 | Jul 21, 2017, 09:48 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Jul 21, 2017 | Option Exercise | $14.12 | 5,888 | 83,133 | 25,450 | Jul 21, 2017, 09:47 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Jul 20, 2017 | Option Exercise | $13.71 | 6,250 | 85,688 | 27,312 | Jul 21, 2017, 09:47 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Jul 20, 2017 | Sale | $42.00 | 6,250 | 262,500 | 21,062 | Jul 21, 2017, 09:47 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Jul 21, 2017 | Sale | $44.00 | 5,888 | 259,072 | 21,062 | Jul 21, 2017, 09:47 PM |
| Howton David T | SVP, General Counsel | Jul 20, 2017 | Option Exercise | $13.71 | 25,000 | 342,750 | 41,357 | Jul 21, 2017, 09:46 PM |
| Howton David T | SVP, General Counsel | Jul 21, 2017 | Option Exercise | $20.56 | 1,000 | 20,565 | 23,301 | Jul 21, 2017, 09:46 PM |
| Howton David T | SVP, General Counsel | Jul 20, 2017 | Sale | $41.00 | 25,000 | 1,025,000 | 22,301 | Jul 21, 2017, 09:46 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Jul 20, 2017 | Option Exercise | $13.71 | 2,500 | 34,275 | 22,793 | Jul 21, 2017, 09:45 PM |
| Cumbo Alexander | SVP, Chief Commercial Officer | Jul 20, 2017 | Sale | $41.00 | 5,918 | 242,638 | 20,293 | Jul 21, 2017, 09:45 PM |
| Kaye Edward M. MD | President & CEO | Apr 20, 2017 | Option Exercise | $32.54 | 4,349 | 141,516 | 66,820 | Apr 24, 2017, 05:11 PM |
| Howton David T | SVP, General Counsel | Mar 19, 2017 | Option Exercise | $30.30 | 152 | 4,606 | 22,301 | Mar 21, 2017, 06:07 PM |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 19, 2017 | Option Exercise | $30.30 | 171 | 5,181 | 32,361 | Mar 21, 2017, 06:05 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Mar 19, 2017 | Option Exercise | $30.30 | 177 | 5,363 | 21,062 | Mar 21, 2017, 06:01 PM |
| Kaye Edward M. MD | President, CEO & CMO | Jan 20, 2017 | Option Exercise | $32.66 | 4,466 | 145,860 | 71,169 | Jan 24, 2017, 05:52 PM |
| Howton David T | SVP, General Counsel | Nov 09, 2016 | Option Exercise | $23.85 | 1,000 | 23,850 | 22,453 | Nov 10, 2016, 08:27 AM |
| Mahatme Sandesh | Senior Vice President, CFO | Nov 09, 2016 | Option Exercise | $23.85 | 1,000 | 23,850 | 32,532 | Nov 10, 2016, 08:26 AM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Nov 08, 2016 | Option Exercise | $26.24 | 1,000 | 26,240 | 21,239 | Nov 10, 2016, 08:20 AM |
| Kaye Edward M. MD | President, CEO & CMO | Nov 09, 2016 | Option Exercise | $8.28 | 3,000 | 24,840 | 75,635 | Nov 10, 2016, 08:19 AM |
| Kaye Edward M. MD | President, CEO & CMO | Oct 20, 2016 | Option Exercise | $49.05 | 4,348 | 213,269 | 72,635 | Oct 24, 2016, 04:33 PM |
| Mahatme Sandesh | Senior Vice President, CFO | Oct 17, 2016 | Option Exercise | $13.90 | 30,000 | 417,000 | 61,532 | Oct 19, 2016, 04:22 PM |
| Mahatme Sandesh | Senior Vice President, CFO | Oct 17, 2016 | Sale | $50.08 | 30,000 | 1,502,502 | 31,532 | Oct 19, 2016, 04:22 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Sep 22, 2016 | Option Exercise | $13.90 | 7,311 | 101,623 | 27,550 | Sep 30, 2016, 09:58 PM |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Sep 22, 2016 | Sale | $60.00 | 7,311 | 438,660 | 20,239 | Sep 30, 2016, 09:58 PM |
| Kaye Edward M. MD | President, CEO & CMO | Sep 22, 2016 | Option Exercise | $8.28 | 40,179 | 332,682 | 117,162 | Sep 26, 2016, 04:23 PM |
| Kaye Edward M. MD | President, CEO & CMO | Sep 22, 2016 | Sale | $60.00 | 40,179 | 2,410,740 | 76,983 | Sep 26, 2016, 04:23 PM |
| Howton David T | SVP, General Counsel | Sep 22, 2016 | Option Exercise | $13.90 | 7,000 | 97,300 | 28,453 | Sep 26, 2016, 04:19 PM |
| Howton David T | SVP, General Counsel | Sep 22, 2016 | Sale | $60.00 | 7,000 | 420,000 | 21,453 | Sep 26, 2016, 04:19 PM |
| Aphale Jayant | VP, Technical Operations | Sep 19, 2016 | Option Exercise | $4.62 | 35,000 | 161,700 | 36,490 | Sep 21, 2016, 09:31 PM |
| Aphale Jayant | VP, Technical Operations | Sep 19, 2016 | Sale | $50.00 | 35,000 | 1,750,000 | 11,490 | Sep 21, 2016, 09:31 PM |
| Kaye Edward M. MD | President, CEO & CMO | Sep 19, 2016 | Option Exercise | $6.94 | 24,352 | 168,941 | 89,983 | Sep 21, 2016, 09:29 PM |
| Kaye Edward M. MD | President, CEO & CMO | Sep 19, 2016 | Sale | $50.00 | 24,352 | 1,217,600 | 76,983 | Sep 21, 2016, 09:29 PM |
| Howton David T | SVP, General Counsel | Sep 19, 2016 | Option Exercise | $13.90 | 8,000 | 111,200 | 11,168 | Sep 21, 2016, 09:28 PM |
| Howton David T | SVP, General Counsel | Sep 19, 2016 | Sale | $50.00 | 9,304 | 465,200 | 21,453 | Sep 21, 2016, 09:28 PM |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Sep 14, 2016 | Sale | $30.00 | 24,557 | 736,710 | 76,983 | Sep 16, 2016, 04:04 PM |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Aug 31, 2016 | Option Exercise | $26.07 | 1,487 | 38,766 | 101,540 | Sep 02, 2016, 04:43 PM |
| Mahatme Sandesh | Senior Vice President, CFO | Aug 31, 2016 | Option Exercise | $26.07 | 1,013 | 26,409 | 7,102 | Sep 02, 2016, 04:37 PM |
| Aphale Jayant | SVP, Technical Operations | Aug 31, 2016 | Option Exercise | $26.07 | 765 | 19,944 | 11,490 | Sep 02, 2016, 04:34 PM |
| Howton David T | SVP, General Counsel | Aug 31, 2016 | Option Exercise | $26.07 | 898 | 23,411 | 3,168 | Sep 02, 2016, 04:32 PM |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Jul 20, 2016 | Option Exercise | $22.46 | 3,001 | 67,402 | 103,027 | Jul 22, 2016, 05:20 PM |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Apr 20, 2016 | Option Exercise | $19.71 | 3,001 | 59,150 | 106,028 | Apr 22, 2016, 04:36 PM |
| BEHRENS M KATHLEEN | Director | Mar 14, 2016 | Buy | $16.54 | 65,000 | 1,075,275 | 112,166 | Mar 16, 2016, 08:15 PM |
| BEHRENS M KATHLEEN | Director | Mar 16, 2016 | Buy | $14.54 | 10,000 | 145,433 | 21,855 | Mar 16, 2016, 08:15 PM |
| Barry Richard | Director | Mar 14, 2016 | Buy | $15.66 | 75,000 | 1,174,185 | 3,241,014 | Mar 16, 2016, 08:09 PM |
| Price Ben Gil | Director | Mar 14, 2016 | Buy | $16.70 | 4,500 | 75,144 | 42,830 | Mar 16, 2016, 08:07 PM |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Jan 20, 2016 | Option Exercise | $13.26 | 3,368 | 44,660 | 103,525 | Jan 25, 2016, 01:28 PM |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Oct 20, 2015 | Option Exercise | $26.74 | 3,001 | 80,247 | 106,893 | Oct 22, 2015, 06:24 PM |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Jul 20, 2015 | Option Exercise | $33.48 | 3,000 | 100,440 | 109,094 | Jul 31, 2015, 04:36 PM |
| Kaye Edward M. MD | SVP & Chief Medical Officer | Feb 27, 2015 | Buy | $11.81 | 800 | 9,452 | 1,311 | Mar 03, 2015, 06:48 PM |
| Christopher Nishan Garabedian | President and CEO | Feb 27, 2015 | Buy | $11.81 | 800 | 9,452 | 29,552 | Mar 03, 2015, 06:47 PM |
| CHASE ANTHONY R | Director | Aug 12, 2014 | Option Exercise | $10.68 | 23,450 | 250,446 | 66,194 | Aug 14, 2014, 04:24 PM |
| Aphale Jayant | SVP Technical Operations | Nov 12, 2013 | Sale | $12.56 | 15,933 | 200,134 | 8,500 | Nov 14, 2013, 09:31 PM |
| CHASE ANTHONY R | Director | Nov 14, 2013 | Buy | $13.95 | 10,000 | 139,483 | 41,744 | Nov 14, 2013, 09:30 PM |
| BEHRENS M KATHLEEN | Director | Sep 16, 2013 | Buy | $37.04 | 6,500 | 240,778 | 44,166 | Sep 18, 2013, 09:00 AM |
| HODGMAN JOHN | Director | Sep 03, 2013 | Option Exercise | $17.52 | 5,556 | 97,341 | 9,889 | Sep 05, 2013, 06:26 PM |
| HODGMAN JOHN | Director | Sep 03, 2013 | Sale | $34.97 | 5,556 | 194,316 | 4,333 | Sep 05, 2013, 06:26 PM |
| CHASE ANTHONY R | Director | Aug 22, 2013 | Buy | $32.68 | 3,500 | 114,373 | 31,744 | Aug 23, 2013, 09:01 AM |
| Price Ben Gil | Director | Aug 19, 2013 | Buy | $31.17 | 500 | 15,587 | 35,330 | Aug 20, 2013, 04:08 PM |
| Mahatme Sandesh | Senior Vice President, CFO | Aug 20, 2013 | Buy | $31.10 | 5,000 | 155,500 | 5,000 | Aug 20, 2013, 01:42 PM |
| CHASE ANTHONY R | Director | Jun 14, 2013 | Buy | $38.50 | 10,000 | 385,043 | 28,244 | Jun 18, 2013, 04:51 PM |
| CHASE ANTHONY R | Director | Nov 27, 2012 | Sale | $29.04 | 1,100 | 31,940 | 26,144 | Nov 29, 2012, 01:46 PM |
| CHASE ANTHONY R | Director | Nov 28, 2012 | Sale | $29.52 | 8,900 | 262,689 | 24,544 | Nov 29, 2012, 01:46 PM |
| CHASE ANTHONY R | Director | Nov 14, 2012 | Sale | $25.70 | 10,000 | 257,002 | 28,044 | Nov 15, 2012, 07:12 PM |
| CHASE ANTHONY R | Director | Sep 07, 2012 | Sale | $14.45 | 33,000 | 476,959 | 56,944 | Sep 11, 2012, 05:40 PM |
| BEHRENS M KATHLEEN | Director | Sep 07, 2012 | Buy | $14.73 | 17,500 | 257,724 | 36,666 | Sep 11, 2012, 05:40 PM |
| Price Ben Gil | Director | Mar 14, 2012 | Buy | $1.29 | 30,000 | 38,850 | 197,982 | Mar 15, 2012, 01:37 PM |
| Christopher Nishan Garabedian | President and CEO | Dec 15, 2011 | Buy | $0.58 | 300,000 | 173,640 | 430,000 | Dec 16, 2011, 11:48 AM |
| CHASE ANTHONY R | Director | Sep 13, 2011 | Buy | $1.20 | 20,000 | 24,000 | 416,467 | Sep 14, 2011, 05:45 PM |
| Price Ben Gil | Director | Apr 06, 2011 | Buy | $1.50 | 20,000 | 30,000 | 162,982 | Apr 06, 2011, 05:38 PM |
| Christopher Nishan Garabedian | President and CEO | Apr 06, 2011 | Buy | $1.50 | 130,000 | 195,000 | 130,000 | Apr 06, 2011, 05:37 PM |
| BEHRENS M KATHLEEN | Director | Apr 06, 2011 | Buy | $1.50 | 100,000 | 150,000 | 105,000 | Apr 06, 2011, 05:36 PM |
| BOYLE J DAVID II | CEO | Aug 27, 2010 | Buy | $2.13 | 5,000 | 10,645 | 70,282 | Aug 27, 2010, 06:02 PM |
| Price Ben Gil | Director | Aug 13, 2010 | Buy | $1.93 | 4,000 | 7,720 | 102,982 | Aug 16, 2010, 03:17 PM |
| Hudson Leslie | Former CEO | Jul 30, 2010 | Option Exercise | $1.09 | 183,486 | 200,000 | 568,045 | Aug 02, 2010, 07:28 PM |
| Hudson Leslie | Former CEO | Jul 30, 2010 | Sale | $1.93 | 183,486 | 354,113 | 518,045 | Aug 02, 2010, 07:28 PM |
| Hudson Leslie | Former CEO | Jul 28, 2010 | Option Exercise | $1.09 | 183,486 | 200,000 | 568,045 | Jul 29, 2010, 08:00 PM |
| Hudson Leslie | Former CEO | Jul 28, 2010 | Sale | $1.82 | 183,486 | 334,373 | 498,045 | Jul 29, 2010, 08:00 PM |
| Hudson Leslie | Former CEO | Jul 26, 2010 | Option Exercise | $1.45 | 129,083 | 187,170 | 513,642 | Jul 28, 2010, 12:48 PM |
| Hudson Leslie | Former CEO | Jul 26, 2010 | Sale | $1.90 | 129,083 | 245,897 | 509,559 | Jul 28, 2010, 12:48 PM |
| Hudson Leslie | Former CEO | Jul 23, 2010 | Option Exercise | $1.45 | 205,400 | 297,830 | 589,959 | Jul 26, 2010, 05:37 PM |
| Hudson Leslie | Former CEO | Jul 23, 2010 | Sale | $1.80 | 205,400 | 369,720 | 384,559 | Jul 26, 2010, 05:37 PM |
| Hudson Leslie | Former CEO | Jul 22, 2010 | Option Exercise | $1.45 | 265,517 | 385,000 | 650,076 | Jul 23, 2010, 05:06 PM |
| Hudson Leslie | Former CEO | Jul 22, 2010 | Sale | $1.80 | 265,517 | 477,513 | 596,280 | Jul 23, 2010, 05:06 PM |
| Owner | Relationship | Date | Transaction | Value($) |
| O'Neill Gilmore Neil | EVP, R&D & CMO | May 24, 2019 | Option Exercise | 552,405 |
| Wigzell Hans Lennart Rudolf | Director | May 23, 2019 | Option Exercise | 78,000 |
| Wigzell Hans Lennart Rudolf | Director | May 23, 2019 | Sale | 1,200,000 |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 28, 2019 | Option Exercise | 350,462 |
| Howton David T | EVP, General Counsel | Mar 28, 2019 | Option Exercise | 280,322 |
| Cumbo Alexander | EVP, Chief Commercial Officer | Mar 28, 2019 | Option Exercise | 256,942 |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 19, 2019 | Option Exercise | 331,984 |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 19, 2019 | Option Exercise | 332,308 |
| Mahatme Sandesh | EVP, CFO & CBO | Feb 07, 2019 | Option Exercise | 1,550,250 |
| Mahatme Sandesh | EVP, CFO & CBO | Feb 07, 2019 | Sale | 9,425,000 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Feb 01, 2019 | Option Exercise | 169,035 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Feb 01, 2019 | Sale | 2,100,000 |
| Howton David T | SVP, General Counsel | Feb 01, 2019 | Option Exercise | 465,391 |
| Howton David T | SVP, General Counsel | Feb 01, 2019 | Sale | 4,200,000 |
| Mahatme Sandesh | EVP, CFO & CBO | Jan 31, 2019 | Option Exercise | 505,572 |
| Mahatme Sandesh | EVP, CFO & CBO | Jan 30, 2019 | Option Exercise | 800,077 |
| Mahatme Sandesh | EVP, CFO & CBO | Jan 31, 2019 | Sale | 2,771,003 |
| Mahatme Sandesh | EVP, CFO & CBO | Jan 30, 2019 | Sale | 5,694,260 |
| Wigzell Hans Lennart Rudolf | Director | Nov 01, 2018 | Option Exercise | 59,603 |
| Wigzell Hans Lennart Rudolf | Director | Nov 01, 2018 | Sale | 936,714 |
| BEHRENS M KATHLEEN | Director | Oct 31, 2018 | Option Exercise | 39,600 |
| BEHRENS M KATHLEEN | Director | Oct 31, 2018 | Sale | 1,317,100 |
| INGRAM DOUGLAS S | President & CEO | Oct 30, 2018 | Buy | 2,009,872 |
| Mahatme Sandesh | EVP, CFO & CBO | Oct 24, 2018 | Option Exercise | 1,330,389 |
| Mahatme Sandesh | EVP, CFO & CBO | Oct 24, 2018 | Sale | 13,735,116 |
| INGRAM DOUGLAS S | President & CEO | Aug 15, 2018 | Buy | 2,004,208 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Aug 08, 2018 | Option Exercise | 726,120 |
| Howton David T | SVP, General Counsel | Aug 08, 2018 | Option Exercise | 822,936 |
| Mahatme Sandesh | EVP, CFO & CBO | Aug 08, 2018 | Option Exercise | 1,028,791 |
| Howton David T | SVP, General Counsel | Jul 16, 2018 | Option Exercise | 692,691 |
| Howton David T | SVP, General Counsel | Jul 16, 2018 | Sale | 6,823,000 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Jul 09, 2018 | Option Exercise | 465,415 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Jul 09, 2018 | Sale | 4,638,944 |
| Barry Richard | Director | Jun 27, 2018 | Sale | 9,775,500 |
| INGRAM DOUGLAS S | President & CEO | Jun 26, 2018 | Option Exercise | 5,007,291 |
| Ruff Shamim | SVP, Chief Regulatory Affairs | May 22, 2018 | Option Exercise | 116,432 |
| Mahatme Sandesh | EVP, CFO & CBO | May 22, 2018 | Option Exercise | 180,581 |
| Howton David T | SVP, General Counsel | May 22, 2018 | Option Exercise | 139,719 |
| Cumbo Alexander | SVP, Chief Commercial Officer | May 22, 2018 | Option Exercise | 128,031 |
| Ruff Shamim | SVP, Chief Regulatory Affairs | Mar 15, 2018 | Option Exercise | 59,778 |
| Ruff Shamim | SVP, Chief Regulatory Affairs | Mar 15, 2018 | Option Exercise | 59,813 |
| Howton David T | SVP, General Counsel | Mar 15, 2018 | Option Exercise | 55,230 |
| Howton David T | SVP, General Counsel | Mar 15, 2018 | Option Exercise | 55,382 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Mar 15, 2018 | Option Exercise | 51,412 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Mar 15, 2018 | Option Exercise | 51,600 |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 15, 2018 | Option Exercise | 59,615 |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 15, 2018 | Option Exercise | 59,625 |
| Wigzell Hans Lennart Rudolf | Director | Nov 30, 2017 | Option Exercise | 49,202 |
| Wigzell Hans Lennart Rudolf | Director | Nov 30, 2017 | Sale | 372,619 |
| INGRAM DOUGLAS S | President & CEO | Nov 08, 2017 | Buy | 1,999,957 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Nov 06, 2017 | Option Exercise | 147,600 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Nov 06, 2017 | Sale | 550,000 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Oct 03, 2017 | Option Exercise | 169,740 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Oct 03, 2017 | Sale | 575,000 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Aug 03, 2017 | Option Exercise | 109,170 |
| Mahatme Sandesh | EVP, CFO & CBO | Aug 03, 2017 | Option Exercise | 237,280 |
| Howton David T | SVP, General Counsel | Aug 03, 2017 | Option Exercise | 175,839 |
| Kaye Edward M. MD | Director | Aug 03, 2017 | Option Exercise | 632,710 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Aug 03, 2017 | Option Exercise | 120,042 |
| INGRAM DOUGLAS S | President & CEO | Jul 27, 2017 | Buy | 1,999,965 |
| Mahatme Sandesh | EVP, CFO & CBO | Jul 20, 2017 | Option Exercise | 769,107 |
| Mahatme Sandesh | EVP, CFO & CBO | Jul 21, 2017 | Option Exercise | 35,775 |
| Mahatme Sandesh | EVP, CFO & CBO | Jul 20, 2017 | Sale | 2,050,000 |
| Kaye Edward M. MD | Director | Jul 20, 2017 | Option Exercise | 178,005 |
| Kaye Edward M. MD | Director | Jul 20, 2017 | Sale | 410,000 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Jul 21, 2017 | Option Exercise | 83,133 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Jul 20, 2017 | Option Exercise | 85,688 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Jul 20, 2017 | Sale | 262,500 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Jul 21, 2017 | Sale | 259,072 |
| Howton David T | SVP, General Counsel | Jul 20, 2017 | Option Exercise | 342,750 |
| Howton David T | SVP, General Counsel | Jul 21, 2017 | Option Exercise | 20,565 |
| Howton David T | SVP, General Counsel | Jul 20, 2017 | Sale | 1,025,000 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Jul 20, 2017 | Option Exercise | 34,275 |
| Cumbo Alexander | SVP, Chief Commercial Officer | Jul 20, 2017 | Sale | 242,638 |
| Kaye Edward M. MD | President & CEO | Apr 20, 2017 | Option Exercise | 141,516 |
| Howton David T | SVP, General Counsel | Mar 19, 2017 | Option Exercise | 4,606 |
| Mahatme Sandesh | EVP, CFO & CBO | Mar 19, 2017 | Option Exercise | 5,181 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Mar 19, 2017 | Option Exercise | 5,363 |
| Kaye Edward M. MD | President, CEO & CMO | Jan 20, 2017 | Option Exercise | 145,860 |
| Howton David T | SVP, General Counsel | Nov 09, 2016 | Option Exercise | 23,850 |
| Mahatme Sandesh | Senior Vice President, CFO | Nov 09, 2016 | Option Exercise | 23,850 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Nov 08, 2016 | Option Exercise | 26,240 |
| Kaye Edward M. MD | President, CEO & CMO | Nov 09, 2016 | Option Exercise | 24,840 |
| Kaye Edward M. MD | President, CEO & CMO | Oct 20, 2016 | Option Exercise | 213,269 |
| Mahatme Sandesh | Senior Vice President, CFO | Oct 17, 2016 | Option Exercise | 417,000 |
| Mahatme Sandesh | Senior Vice President, CFO | Oct 17, 2016 | Sale | 1,502,502 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Sep 22, 2016 | Option Exercise | 101,623 |
| Ruff Shamim | SVP, Regulatory Affairs & Qual | Sep 22, 2016 | Sale | 438,660 |
| Kaye Edward M. MD | President, CEO & CMO | Sep 22, 2016 | Option Exercise | 332,682 |
| Kaye Edward M. MD | President, CEO & CMO | Sep 22, 2016 | Sale | 2,410,740 |
| Howton David T | SVP, General Counsel | Sep 22, 2016 | Option Exercise | 97,300 |
| Howton David T | SVP, General Counsel | Sep 22, 2016 | Sale | 420,000 |
| Aphale Jayant | VP, Technical Operations | Sep 19, 2016 | Option Exercise | 161,700 |
| Aphale Jayant | VP, Technical Operations | Sep 19, 2016 | Sale | 1,750,000 |
| Kaye Edward M. MD | President, CEO & CMO | Sep 19, 2016 | Option Exercise | 168,941 |
| Kaye Edward M. MD | President, CEO & CMO | Sep 19, 2016 | Sale | 1,217,600 |
| Howton David T | SVP, General Counsel | Sep 19, 2016 | Option Exercise | 111,200 |
| Howton David T | SVP, General Counsel | Sep 19, 2016 | Sale | 465,200 |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Sep 14, 2016 | Sale | 736,710 |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Aug 31, 2016 | Option Exercise | 38,766 |
| Mahatme Sandesh | Senior Vice President, CFO | Aug 31, 2016 | Option Exercise | 26,409 |
| Aphale Jayant | SVP, Technical Operations | Aug 31, 2016 | Option Exercise | 19,944 |
| Howton David T | SVP, General Counsel | Aug 31, 2016 | Option Exercise | 23,411 |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Jul 20, 2016 | Option Exercise | 67,402 |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Apr 20, 2016 | Option Exercise | 59,150 |
| BEHRENS M KATHLEEN | Director | Mar 14, 2016 | Buy | 1,075,275 |
| BEHRENS M KATHLEEN | Director | Mar 16, 2016 | Buy | 145,433 |
| Barry Richard | Director | Mar 14, 2016 | Buy | 1,174,185 |
| Price Ben Gil | Director | Mar 14, 2016 | Buy | 75,144 |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Jan 20, 2016 | Option Exercise | 44,660 |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Oct 20, 2015 | Option Exercise | 80,247 |
| Kaye Edward M. MD | SVP Interim CEO & CMO | Jul 20, 2015 | Option Exercise | 100,440 |
| Kaye Edward M. MD | SVP & Chief Medical Officer | Feb 27, 2015 | Buy | 9,452 |
| Christopher Nishan Garabedian | President and CEO | Feb 27, 2015 | Buy | 9,452 |
| CHASE ANTHONY R | Director | Aug 12, 2014 | Option Exercise | 250,446 |
| Aphale Jayant | SVP Technical Operations | Nov 12, 2013 | Sale | 200,134 |
| CHASE ANTHONY R | Director | Nov 14, 2013 | Buy | 139,483 |
| BEHRENS M KATHLEEN | Director | Sep 16, 2013 | Buy | 240,778 |
| HODGMAN JOHN | Director | Sep 03, 2013 | Option Exercise | 97,341 |
| HODGMAN JOHN | Director | Sep 03, 2013 | Sale | 194,316 |
| CHASE ANTHONY R | Director | Aug 22, 2013 | Buy | 114,373 |
| Price Ben Gil | Director | Aug 19, 2013 | Buy | 15,587 |
| Mahatme Sandesh | Senior Vice President, CFO | Aug 20, 2013 | Buy | 155,500 |
| CHASE ANTHONY R | Director | Jun 14, 2013 | Buy | 385,043 |
| CHASE ANTHONY R | Director | Nov 27, 2012 | Sale | 31,940 |
| CHASE ANTHONY R | Director | Nov 28, 2012 | Sale | 262,689 |
| CHASE ANTHONY R | Director | Nov 14, 2012 | Sale | 257,002 |
| CHASE ANTHONY R | Director | Sep 07, 2012 | Sale | 476,959 |
| BEHRENS M KATHLEEN | Director | Sep 07, 2012 | Buy | 257,724 |
| Price Ben Gil | Director | Mar 14, 2012 | Buy | 38,850 |
| Christopher Nishan Garabedian | President and CEO | Dec 15, 2011 | Buy | 173,640 |
| CHASE ANTHONY R | Director | Sep 13, 2011 | Buy | 24,000 |
| Price Ben Gil | Director | Apr 06, 2011 | Buy | 30,000 |
| Christopher Nishan Garabedian | President and CEO | Apr 06, 2011 | Buy | 195,000 |
| BEHRENS M KATHLEEN | Director | Apr 06, 2011 | Buy | 150,000 |
| BOYLE J DAVID II | CEO | Aug 27, 2010 | Buy | 10,645 |
| Price Ben Gil | Director | Aug 13, 2010 | Buy | 7,720 |
| Hudson Leslie | Former CEO | Jul 30, 2010 | Option Exercise | 200,000 |
| Hudson Leslie | Former CEO | Jul 30, 2010 | Sale | 354,113 |
| Hudson Leslie | Former CEO | Jul 28, 2010 | Option Exercise | 200,000 |
| Hudson Leslie | Former CEO | Jul 28, 2010 | Sale | 334,373 |
| Hudson Leslie | Former CEO | Jul 26, 2010 | Option Exercise | 187,170 |
| Hudson Leslie | Former CEO | Jul 26, 2010 | Sale | 245,897 |
| Hudson Leslie | Former CEO | Jul 23, 2010 | Option Exercise | 297,830 |
| Hudson Leslie | Former CEO | Jul 23, 2010 | Sale | 369,720 |
| Hudson Leslie | Former CEO | Jul 22, 2010 | Option Exercise | 385,000 |
| Hudson Leslie | Former CEO | Jul 22, 2010 | Sale | 477,513 |