Insider Transactions for LIGAND PHARMACEUTICALS INC (LGND)

Owner Relationship Date Transaction Cost # Shares Value($) Total Shares Form 4
Aryeh Jason Director Jun 11, 2019 Buy $107.01 250 26,753 61,703 Jun 12, 2019, 06:51 PM
FOEHR MATTHEW W President and COO Jun 11, 2019 Option Exercise $21.92 1,004 22,008 141,451 Jun 12, 2019, 06:50 PM
HIGGINS JOHN L Chief Executive Officer May 31, 2019 Buy $108.20 1,000 108,202 144,899 May 31, 2019, 07:29 PM
Aryeh Jason Director May 31, 2019 Buy $108.51 500 54,255 60,618 May 31, 2019, 06:27 PM
Aryeh Jason Director May 30, 2019 Buy $110.01 250 27,503 60,118 May 31, 2019, 06:27 PM
Aryeh Jason Director May 29, 2019 Buy $111.01 250 27,753 59,868 May 31, 2019, 06:27 PM
Aryeh Jason Director May 20, 2019 Buy $112.01 250 28,003 59,618 May 22, 2019, 05:36 PM
Aryeh Jason Director May 14, 2019 Buy $112.51 250 28,128 59,368 May 16, 2019, 03:54 PM
HIGGINS JOHN L Chief Executive Officer May 14, 2019 Buy $113.50 2,500 283,750 143,899 May 14, 2019, 07:57 PM
KOZARICH JOHN W Director May 14, 2019 Option Exercise $17.88 2,500 44,700 28,042 May 14, 2019, 07:56 PM
KOZARICH JOHN W Director May 14, 2019 Sale $112.92 2,500 282,300 25,542 May 14, 2019, 07:56 PM
FOEHR MATTHEW W President and COO Mar 14, 2019 Option Exercise $9.97 14,894 148,493 140,447 Mar 15, 2019, 02:00 PM
Aryeh Jason Director Mar 13, 2019 Buy $112.51 202 22,727 51,594 Mar 15, 2019, 01:59 PM
HIGGINS JOHN L Chief Executive Officer Mar 13, 2019 Buy $114.29 2,500 285,725 141,399 Mar 15, 2019, 01:58 PM
FOEHR MATTHEW W President and COO Jan 23, 2019 Option Exercise $111.78 2,568 287,051 118,081 Jan 25, 2019, 04:31 PM
HIGGINS JOHN L Chief Executive Officer Jan 23, 2019 Option Exercise $111.78 6,765 756,192 126,090 Jan 25, 2019, 04:31 PM
Korenberg Matthew E EVP,Finance & Strategy and CFO Jan 23, 2019 Option Exercise $111.78 1,325 148,108 10,065 Jan 25, 2019, 04:30 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Jan 10, 2019 Option Exercise $65.62 2,850 187,029 39,913 Jan 14, 2019, 09:17 AM
HIGGINS JOHN L Chief Executive Officer Jan 10, 2019 Option Exercise $16.14 33,790 545,371 119,209 Jan 14, 2019, 09:16 AM
Berkman Charles S SVP, Gen. Counsel & Secretary Dec 17, 2018 Option Exercise $21.92 3,400 74,528 37,063 Dec 17, 2018, 07:58 PM
FOEHR MATTHEW W President and COO Dec 12, 2018 Option Exercise $9.97 7,999 79,750 113,387 Dec 12, 2018, 05:32 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Oct 24, 2018 Option Exercise $16.79 3,900 65,462 33,663 Oct 25, 2018, 05:44 PM
Davis Todd C Director Oct 12, 2018 Option Exercise $103.29 5,083 525,021 47,639 Oct 15, 2018, 12:55 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Oct 11, 2018 Option Exercise $14.47 2,000 28,940 29,763 Oct 12, 2018, 06:52 PM
Davis Todd C Director Oct 08, 2018 Sale $253.99 2,500 634,978 42,556 Oct 09, 2018, 04:24 PM
KOZARICH JOHN W Director Oct 01, 2018 Sale $275.04 2,500 687,610 26,142 Oct 02, 2018, 06:24 PM
FOEHR MATTHEW W President and COO Oct 01, 2018 Option Exercise $13.80 14,088 194,457 117,388 Oct 02, 2018, 06:24 PM
FOEHR MATTHEW W President and COO Oct 01, 2018 Sale $273.88 12,000 3,286,560 105,388 Oct 02, 2018, 06:24 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Sep 17, 2018 Option Exercise $100.38 2,813 282,369 30,576 Sep 18, 2018, 06:16 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Sep 17, 2018 Sale $250.69 2,813 705,183 27,763 Sep 18, 2018, 06:16 PM
Sabba Stephen L Director Sep 04, 2018 Option Exercise $13.23 5,000 66,150 31,856 Sep 06, 2018, 10:40 AM
Sabba Stephen L Director Sep 04, 2018 Sale $255.05 5,000 1,275,250 26,856 Sep 06, 2018, 10:40 AM
FOEHR MATTHEW W President and COO Sep 04, 2018 Option Exercise $14.11 13,044 184,049 115,300 Sep 05, 2018, 08:18 PM
FOEHR MATTHEW W President and COO Sep 04, 2018 Sale $255.01 12,000 3,060,084 103,300 Sep 05, 2018, 08:18 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Sep 04, 2018 Option Exercise $69.98 19,417 1,358,796 47,180 Sep 05, 2018, 08:00 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Sep 04, 2018 Sale $254.99 19,417 4,951,063 27,763 Sep 05, 2018, 08:00 PM
LAMATTINA JOHN L Director Sep 04, 2018 Option Exercise $12.53 3,335 41,788 24,784 Sep 05, 2018, 07:59 PM
LAMATTINA JOHN L Director Sep 04, 2018 Sale $254.96 3,335 850,292 21,449 Sep 05, 2018, 07:59 PM
HIGGINS JOHN L Chief Executive Officer Aug 30, 2018 Sale $258.25 3,500 903,875 85,419 Aug 31, 2018, 01:22 PM
Korenberg Matthew E EVP,Finance & Strategy and CFO Aug 29, 2018 Option Exercise $85.79 11,540 990,017 25,099 Aug 29, 2018, 08:35 PM
Korenberg Matthew E EVP,Finance & Strategy and CFO Aug 29, 2018 Sale $256.69 18,357 4,712,058 6,742 Aug 29, 2018, 08:35 PM
Aryeh Jason Director Aug 17, 2018 Sale $241.81 26,862 6,495,554 51,392 Aug 17, 2018, 07:38 PM
Aryeh Jason Director Aug 16, 2018 Sale $245.00 1,080 264,600 78,254 Aug 17, 2018, 07:38 PM
Davis Todd C Director Aug 17, 2018 Sale $239.50 3,167 758,497 45,056 Aug 17, 2018, 07:38 PM
Davis Todd C Director Aug 16, 2018 Sale $239.93 5,833 1,399,506 48,223 Aug 17, 2018, 07:38 PM
HIGGINS JOHN L Chief Executive Officer Aug 17, 2018 Option Exercise $14.47 12,993 188,009 101,912 Aug 17, 2018, 07:37 PM
HIGGINS JOHN L Chief Executive Officer Aug 16, 2018 Option Exercise $14.47 3,007 43,511 110,426 Aug 17, 2018, 07:37 PM
HIGGINS JOHN L Chief Executive Officer Aug 17, 2018 Sale $243.00 12,993 3,157,299 88,919 Aug 17, 2018, 07:37 PM
HIGGINS JOHN L Chief Executive Officer Aug 16, 2018 Sale $241.33 21,507 5,190,263 88,919 Aug 17, 2018, 07:37 PM
Patel Sunil Director Aug 16, 2018 Option Exercise $16.70 27,005 451,058 66,811 Aug 17, 2018, 07:37 PM
Patel Sunil Director Aug 16, 2018 Sale $240.05 42,287 10,150,825 24,524 Aug 17, 2018, 07:37 PM
Korenberg Matthew E EVP,Finance & Strategy and CFO Aug 06, 2018 Option Exercise $226.74 836 189,555 13,559 Aug 07, 2018, 04:35 PM
KOZARICH JOHN W Director Jul 02, 2018 Sale $207.48 2,500 518,700 28,642 Jul 03, 2018, 06:50 PM
Korenberg Matthew E EVP,Finance & Strategy and CFO Jun 29, 2018 Option Exercise $117.84 180 21,210 14,395 Jul 03, 2018, 03:27 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Jun 29, 2018 Option Exercise $117.84 180 21,210 27,763 Jul 03, 2018, 03:27 PM
LAMATTINA JOHN L Director Jun 04, 2018 Option Exercise $12.53 4,000 50,120 24,956 Jun 04, 2018, 07:01 PM
LAMATTINA JOHN L Director Jun 04, 2018 Sale $194.51 4,000 778,040 20,956 Jun 04, 2018, 07:01 PM
HIGGINS JOHN L Chief Executive Officer May 15, 2018 Option Exercise $16.14 12,405 200,217 119,824 May 15, 2018, 06:41 PM
HIGGINS JOHN L Chief Executive Officer May 15, 2018 Sale $179.97 12,405 2,232,491 107,419 May 15, 2018, 06:41 PM
FOEHR MATTHEW W President and COO May 10, 2018 Option Exercise $13.99 9,936 139,026 110,082 May 11, 2018, 05:32 PM
FOEHR MATTHEW W President and COO May 10, 2018 Sale $167.63 8,881 1,488,687 101,201 May 11, 2018, 05:32 PM
KOZARICH JOHN W Director Apr 02, 2018 Sale $160.43 2,500 401,063 30,649 Apr 03, 2018, 12:00 AM
Sabba Stephen L Director Mar 12, 2018 Sale $180.73 622 112,414 26,363 Mar 13, 2018, 06:15 PM
Aryeh Jason Director Mar 09, 2018 Sale $176.48 4,000 705,900 79,334 Mar 09, 2018, 06:28 PM
Aryeh Jason Director Mar 08, 2018 Sale $174.88 3,500 612,094 83,334 Mar 09, 2018, 06:28 PM
LAMATTINA JOHN L Director Mar 05, 2018 Option Exercise $10.12 3,335 33,750 24,291 Mar 06, 2018, 06:36 PM
LAMATTINA JOHN L Director Mar 05, 2018 Sale $160.90 3,335 536,605 20,956 Mar 06, 2018, 06:36 PM
Korenberg Matthew E EVP,Finance & Strategy and CFO Mar 06, 2018 Option Exercise $165.87 550 91,228 14,215 Mar 06, 2018, 06:36 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Mar 06, 2018 Option Exercise $165.87 392 65,021 27,583 Mar 06, 2018, 06:36 PM
HIGGINS JOHN L Chief Executive Officer Mar 06, 2018 Option Exercise $165.87 2,982 494,624 107,419 Mar 06, 2018, 06:36 PM
FOEHR MATTHEW W President and COO Mar 06, 2018 Option Exercise $165.87 1,457 241,673 101,201 Mar 06, 2018, 06:36 PM
Aryeh Jason Director Feb 23, 2018 Sale $155.00 3,417 529,635 86,834 Feb 27, 2018, 06:40 PM
Davis Todd C Director Feb 27, 2018 Sale $151.90 12,335 1,873,711 53,563 Feb 27, 2018, 06:39 PM
Davis Todd C Director Feb 26, 2018 Sale $153.57 4,835 742,535 65,898 Feb 27, 2018, 06:39 PM
FOEHR MATTHEW W President and COO Feb 23, 2018 Option Exercise $13.77 6,448 88,785 101,279 Feb 27, 2018, 06:39 PM
FOEHR MATTHEW W President and COO Feb 23, 2018 Sale $152.98 5,444 832,823 95,835 Feb 27, 2018, 06:39 PM
Berkman Charles S SVP, Gen. Counsel & Secretary Feb 15, 2018 Option Exercise $157.18 1,036 162,838 25,571 Feb 16, 2018, 05:40 PM
FOEHR MATTHEW W President and COO Feb 15, 2018 Option Exercise $157.18 3,663 575,750 96,983 Feb 16, 2018, 05:39 PM
HIGGINS JOHN L Chief Executive Officer Feb 15, 2018 Option Exercise $157.18 6,242 981,118 100,065 Feb 16, 2018, 05:38 PM
HIGGINS JOHN L Chief Executive Officer Feb 15, 2018 Sale $157.03 9,000 1,413,279 102,700 Feb 16, 2018, 05:38 PM
Korenberg Matthew E EVP,Finance & Strategy and CFO Feb 15, 2018 Option Exercise $157.18 680 106,882 10,013 Feb 16, 2018, 05:37 PM
HIGGINS JOHN L Chief Executive Officer Jan 24, 2018 Sale $165.00 22,500 3,712,500 111,700 Jan 26, 2018, 05:31 PM
HIGGINS JOHN L Chief Executive Officer Jan 19, 2018 Option Exercise $16.14 16,249 262,259 162,299 Jan 22, 2018, 07:23 PM
HIGGINS JOHN L Chief Executive Officer Jan 19, 2018 Sale $153.70 28,099 4,318,906 146,050 Jan 22, 2018, 07:23 PM
KOZARICH JOHN W Director Jan 10, 2018 Sale $145.00 2,500 362,500 33,149 Jan 11, 2018, 05:55 PM
Korenberg Matthew E VP, Finance and CFO Dec 28, 2017 Option Exercise $138.66 1,530 212,150 10,367 Dec 29, 2017, 09:17 PM
FOEHR MATTHEW W President and COO Dec 28, 2017 Option Exercise $138.66 2,971 411,959 98,494 Dec 29, 2017, 09:17 PM
HIGGINS JOHN L Chief Executive Officer Dec 28, 2017 Option Exercise $138.66 5,199 720,893 146,050 Dec 29, 2017, 09:16 PM
Berkman Charles S VP, Gen. Counsel & Secretary Dec 28, 2017 Option Exercise $138.66 1,175 162,926 26,095 Dec 29, 2017, 09:16 PM
Sabba Stephen L Director Dec 20, 2017 Sale $137.25 925 126,956 26,985 Dec 21, 2017, 06:31 AM
Aryeh Jason Director Nov 17, 2017 Sale $140.22 24,400 3,421,368 90,251 Nov 20, 2017, 05:01 PM
HIGGINS JOHN L Chief Executive Officer Nov 17, 2017 Sale $140.34 2,258 316,888 141,284 Nov 20, 2017, 05:01 PM
LAMATTINA JOHN L Director Nov 17, 2017 Option Exercise $10.12 4,000 40,480 24,956 Nov 17, 2017, 07:19 PM
LAMATTINA JOHN L Director Nov 17, 2017 Sale $139.79 4,000 559,160 20,956 Nov 17, 2017, 07:19 PM
KOZARICH JOHN W Director Nov 16, 2017 Sale $141.71 5,000 708,550 35,649 Nov 17, 2017, 05:14 PM
Korenberg Matthew E VP, Finance and CFO Nov 17, 2017 Sale $142.63 6,559 935,510 8,147 Nov 17, 2017, 05:11 PM
HIGGINS JOHN L Chief Executive Officer Nov 16, 2017 Sale $142.53 5,269 750,991 143,542 Nov 17, 2017, 05:10 PM
HIGGINS JOHN L Chief Executive Officer Oct 13, 2017 Option Exercise $143.04 1,744 249,462 148,811 Oct 17, 2017, 05:39 PM
HIGGINS JOHN L Chief Executive Officer Oct 13, 2017 Option Exercise $21.92 11,384 249,537 150,555 Oct 17, 2017, 05:39 PM
HIGGINS JOHN L Chief Executive Officer Sep 05, 2017 Option Exercise $21.00 5,000 105,000 144,171 Sep 06, 2017, 08:48 PM
HIGGINS JOHN L Chief Executive Officer Sep 05, 2017 Sale $130.00 5,000 650,000 139,171 Sep 06, 2017, 08:48 PM
Aryeh Jason Director Aug 23, 2017 Sale $127.99 2,000 255,980 114,651 Aug 25, 2017, 05:36 PM
FOEHR MATTHEW W President and COO Aug 09, 2017 Option Exercise $9.97 6,950 69,292 101,020 Aug 10, 2017, 06:40 PM
FOEHR MATTHEW W President and COO Aug 09, 2017 Sale $127.51 6,100 777,823 94,920 Aug 10, 2017, 06:40 PM
Berkman Charles S VP, Gen. Counsel & Secretary Aug 09, 2017 Sale $126.96 18,625 2,364,667 24,423 Aug 10, 2017, 06:40 PM
HIGGINS JOHN L Chief Executive Officer Aug 08, 2017 Option Exercise $21.00 5,483 115,143 144,654 Aug 10, 2017, 06:39 PM
HIGGINS JOHN L Chief Executive Officer Aug 08, 2017 Sale $125.00 5,483 685,375 139,171 Aug 10, 2017, 06:39 PM
Korenberg Matthew E VP, Finance and CFO Aug 06, 2017 Option Exercise $122.06 609 74,335 14,706 Aug 08, 2017, 05:50 PM
Berkman Charles S VP, Gen. Counsel & Secretary Jun 30, 2017 Option Exercise $87.13 243 21,171 43,048 Jul 05, 2017, 06:45 PM
Korenberg Matthew E VP, Finance and CFO Jun 30, 2017 Option Exercise $87.13 243 21,171 15,315 Jul 05, 2017, 06:44 PM
HIGGINS JOHN L Chief Executive Officer Jun 21, 2017 Option Exercise $21.00 4,666 97,986 143,837 Jun 23, 2017, 04:16 PM
HIGGINS JOHN L Chief Executive Officer Jun 21, 2017 Sale $120.00 4,666 559,920 139,171 Jun 23, 2017, 04:16 PM
HIGGINS JOHN L Chief Executive Officer Jun 09, 2017 Option Exercise $21.00 12,000 252,000 151,171 Jun 09, 2017, 07:26 PM
HIGGINS JOHN L Chief Executive Officer Jun 09, 2017 Sale $114.87 12,000 1,378,440 139,171 Jun 09, 2017, 07:26 PM
FOEHR MATTHEW W President and COO May 12, 2017 Option Exercise $9.97 5,621 56,041 98,341 May 15, 2017, 07:05 PM
FOEHR MATTHEW W President and COO May 15, 2017 Option Exercise $9.97 2,200 21,934 94,920 May 15, 2017, 07:05 PM
FOEHR MATTHEW W President and COO May 12, 2017 Sale $112.19 5,621 630,648 92,720 May 15, 2017, 07:05 PM
Aryeh Jason Director May 12, 2017 Sale $111.87 14,582 1,631,332 116,651 May 12, 2017, 08:06 PM
Aryeh Jason Director May 11, 2017 Sale $110.04 22,665 2,494,034 131,233 May 12, 2017, 08:06 PM
HIGGINS JOHN L Chief Executive Officer Mar 20, 2017 Sale $109.10 4,000 436,400 139,171 Mar 21, 2017, 05:49 PM
HIGGINS JOHN L Chief Executive Officer Mar 08, 2017 Option Exercise $106.92 1,473 157,493 143,171 Mar 10, 2017, 06:03 PM
HIGGINS JOHN L Chief Executive Officer Mar 08, 2017 Option Exercise $10.05 15,675 157,534 144,644 Mar 10, 2017, 06:03 PM
HIGGINS JOHN L Chief Executive Officer Mar 08, 2017 Sale $107.06 4,000 428,240 128,969 Mar 10, 2017, 06:03 PM
FOEHR MATTHEW W President and COO Mar 03, 2017 Option Exercise $9.97 2,000 19,940 92,720 Mar 03, 2017, 06:54 PM
FOEHR MATTHEW W President and COO Mar 02, 2017 Option Exercise $9.97 6,879 68,584 97,599 Mar 03, 2017, 06:54 PM
FOEHR MATTHEW W President and COO Mar 02, 2017 Sale $103.39 6,879 711,213 90,720 Mar 03, 2017, 06:54 PM
Aryeh Jason Director Feb 28, 2017 Sale $107.58 7,000 753,060 153,898 Feb 28, 2017, 08:30 PM
Aryeh Jason Director Feb 27, 2017 Sale $106.00 25,000 2,650,000 160,898 Feb 28, 2017, 08:30 PM
Korenberg Matthew E VP, Finance and CFO Feb 24, 2017 Option Exercise $100.38 1,051 105,499 11,505 Feb 28, 2017, 06:27 PM
Korenberg Matthew E VP, Finance and CFO Feb 15, 2017 Option Exercise $104.28 391 40,773 9,106 Feb 28, 2017, 06:27 PM
Korenberg Matthew E VP, Finance and CFO Aug 06, 2016 Option Exercise $123.30 609 75,090 9,457 Feb 28, 2017, 06:27 PM
FOEHR MATTHEW W President and COO Feb 15, 2017 Option Exercise $104.28 2,367 246,831 81,395 Feb 28, 2017, 06:27 PM
FOEHR MATTHEW W President and COO Feb 24, 2017 Option Exercise $100.38 2,733 274,339 83,176 Feb 28, 2017, 06:27 PM
HIGGINS JOHN L Chief Executive Officer Feb 24, 2017 Option Exercise $100.38 4,783 480,118 122,745 Feb 28, 2017, 06:26 PM
HIGGINS JOHN L Chief Executive Officer Feb 15, 2017 Option Exercise $104.28 4,304 448,821 120,379 Feb 28, 2017, 06:26 PM
Korenberg Matthew E VP, Finance and CFO Dec 30, 2016 Option Exercise $86.37 40 3,455 10,106 Jan 03, 2017, 04:38 PM
Aryeh Jason Director Nov 25, 2016 Sale $106.96 3,478 372,007 185,898 Nov 25, 2016, 05:58 PM
Aryeh Jason Director Nov 22, 2016 Sale $107.40 15,001 1,611,062 189,376 Nov 25, 2016, 05:58 PM
Aryeh Jason Director Nov 16, 2016 Sale $106.33 1,330 141,419 209,377 Nov 18, 2016, 04:48 PM
Aryeh Jason Director Nov 18, 2016 Sale $105.00 5,000 525,000 204,377 Nov 18, 2016, 04:48 PM
Davis Todd C Director Oct 31, 2016 Option Exercise $45.66 13,980 638,362 70,189 Nov 01, 2016, 08:18 PM
HIGGINS JOHN L Chief Executive Officer Sep 22, 2016 Sale $117.34 3,000 352,020 122,664 Sep 23, 2016, 04:19 PM
KOZARICH JOHN W Director Sep 07, 2016 Sale $115.00 1,000 115,000 39,983 Sep 09, 2016, 04:06 PM
KOZARICH JOHN W Director Sep 01, 2016 Option Exercise $45.60 1,666 75,970 40,983 Sep 09, 2016, 04:05 PM
KOZARICH JOHN W Director Sep 01, 2016 Sale $105.40 1,666 175,597 40,783 Sep 06, 2016, 06:07 PM
FOEHR MATTHEW W President and COO Aug 08, 2016 Option Exercise $9.97 4,125 41,126 83,037 Aug 09, 2016, 04:58 PM
FOEHR MATTHEW W President and COO Aug 05, 2016 Option Exercise $9.97 12,500 124,625 91,412 Aug 09, 2016, 04:58 PM
FOEHR MATTHEW W President and COO Aug 05, 2016 Sale $122.14 12,500 1,526,750 78,912 Aug 09, 2016, 04:58 PM
Berkman Charles S VP, Gen. Counsel & Secretary Aug 05, 2016 Option Exercise $54.76 30,347 1,661,857 41,731 Aug 09, 2016, 04:58 PM
Berkman Charles S VP, Gen. Counsel & Secretary Aug 05, 2016 Sale $123.16 22,067 2,717,772 29,647 Aug 09, 2016, 04:58 PM
KOZARICH JOHN W Director Aug 01, 2016 Sale $137.57 1,000 137,569 41,783 Aug 02, 2016, 07:46 PM
Korenberg Matthew E VP, Finance and CFO Jun 30, 2016 Option Exercise $87.10 196 17,072 10,066 Jul 05, 2016, 07:58 PM
Herman Melanie J Director of Accounting Jun 30, 2016 Option Exercise $87.10 157 13,675 3,454 Jul 05, 2016, 07:56 PM
KOZARICH JOHN W Director Jul 01, 2016 Sale $121.40 1,000 121,402 42,883 Jul 05, 2016, 07:56 PM
KOZARICH JOHN W Director Jun 01, 2016 Sale $117.42 1,000 117,419 43,083 Jun 03, 2016, 04:41 PM
Herman Melanie J Director of Accounting May 18, 2016 Sale $120.50 334 40,247 3,297 May 19, 2016, 06:28 PM
Aryeh Jason Director May 06, 2016 Sale $118.52 15,000 1,777,830 210,707 May 09, 2016, 08:00 AM
Aryeh Jason Director May 05, 2016 Sale $120.21 10,000 1,202,120 225,707 May 09, 2016, 08:00 AM
KOZARICH JOHN W Director May 02, 2016 Sale $121.57 1,000 121,568 43,911 May 03, 2016, 05:34 PM
KOZARICH JOHN W Director Apr 06, 2016 Sale $115.00 5,000 575,000 44,711 Apr 07, 2016, 05:30 PM
FOEHR MATTHEW W President and COO Mar 17, 2016 Option Exercise $9.97 8,650 86,241 83,062 Mar 17, 2016, 07:56 PM
FOEHR MATTHEW W President and COO Mar 17, 2016 Sale $96.70 6,400 618,880 76,662 Mar 17, 2016, 07:56 PM
Aryeh Jason Director Mar 07, 2016 Sale $101.07 5,629 568,895 236,207 Mar 09, 2016, 06:26 PM
Aryeh Jason Director Mar 08, 2016 Sale $102.49 500 51,245 235,707 Mar 09, 2016, 06:26 PM
HIGGINS JOHN L Chief Executive Officer Mar 08, 2016 Option Exercise $21.00 6,000 126,000 125,664 Mar 09, 2016, 06:26 PM
HIGGINS JOHN L Chief Executive Officer Mar 07, 2016 Sale $102.47 10,833 1,110,027 120,220 Mar 09, 2016, 06:26 PM
HIGGINS JOHN L Chief Executive Officer Feb 15, 2016 Option Exercise $85.97 2,492 214,237 130,497 Feb 16, 2016, 07:34 PM
FOEHR MATTHEW W President and COO Feb 15, 2016 Option Exercise $85.97 1,642 141,163 76,662 Feb 16, 2016, 07:34 PM
Herman Melanie J Director of Accounting Feb 15, 2016 Option Exercise $85.97 160 13,755 3,631 Feb 16, 2016, 07:33 PM
KOZARICH JOHN W Director Jan 20, 2016 Option Exercise $59.40 1,666 98,960 51,377 Jan 22, 2016, 07:24 PM
KOZARICH JOHN W Director Jan 20, 2016 Sale $94.94 1,666 158,173 51,077 Jan 22, 2016, 07:24 PM
Herman Melanie J Director of Accounting Dec 31, 2015 Option Exercise $82.53 140 11,554 3,291 Jan 04, 2016, 05:24 PM
Aryeh Jason Director Nov 11, 2015 Sale $101.49 3,000 304,470 241,836 Nov 13, 2015, 05:29 PM
Herman Melanie J Director of Accounting Nov 11, 2015 Option Exercise $47.29 7,719 365,034 10,870 Nov 13, 2015, 05:28 PM
Herman Melanie J Director of Accounting Nov 11, 2015 Sale $101.00 7,719 779,619 3,151 Nov 13, 2015, 05:28 PM
KNOTT DAVID M Director Aug 17, 2015 Sale $95.98 4,000 383,937 66,152 Aug 19, 2015, 06:00 AM
KNOTT DAVID M Director Aug 12, 2015 Sale $96.45 800 77,163 971,300 Aug 14, 2015, 12:53 PM
KNOTT DAVID M Director Aug 13, 2015 Sale $96.20 27,300 2,626,143 196,186 Aug 14, 2015, 12:53 PM
KNOTT DAVID M Director Aug 13, 2015 Sale $96.20 2,000 192,391 969,300 Aug 14, 2015, 12:53 PM
KNOTT DAVID M Director Aug 12, 2015 Sale $96.45 2,600 250,781 37,996 Aug 14, 2015, 12:53 PM
KNOTT DAVID M Director Aug 12, 2015 Sale $96.45 9,875 952,486 223,486 Aug 14, 2015, 12:53 PM
KNOTT DAVID M Director Aug 13, 2015 Sale $96.20 7,225 695,014 30,771 Aug 14, 2015, 12:53 PM
KNOTT DAVID M Director Aug 07, 2015 Sale $99.01 200 19,803 40,596 Aug 11, 2015, 06:51 AM
HIGGINS JOHN L Chief Executive Officer Aug 06, 2015 Sale $110.79 4,666 516,946 121,378 Aug 07, 2015, 04:22 PM
Davis Todd C Director Aug 06, 2015 Option Exercise $11.81 19,670 232,288 55,449 Aug 06, 2015, 07:49 PM
Berkman Charles S VP, Gen. Counsel & Secretary Jul 10, 2015 Option Exercise $12.70 14,067 178,687 40,521 Jul 14, 2015, 07:35 PM
Berkman Charles S VP, Gen. Counsel & Secretary Jul 13, 2015 Option Exercise $53.10 1,000 53,100 27,454 Jul 14, 2015, 07:35 PM
Berkman Charles S VP, Gen. Counsel & Secretary Jul 10, 2015 Sale $99.14 14,067 1,394,610 38,117 Jul 14, 2015, 07:35 PM
Berkman Charles S VP, Gen. Counsel & Secretary Jun 30, 2015 Option Exercise $45.67 465 21,237 26,454 Jul 01, 2015, 12:36 PM
Herman Melanie J Interim CFO Jun 30, 2015 Option Exercise $45.67 165 7,536 3,151 Jul 01, 2015, 12:36 PM
FOEHR MATTHEW W President and COO Jun 26, 2015 Option Exercise $9.97 12,500 124,625 82,628 Jun 30, 2015, 05:39 PM
FOEHR MATTHEW W President and COO Jun 29, 2015 Option Exercise $9.97 2,500 24,925 72,628 Jun 30, 2015, 05:39 PM
FOEHR MATTHEW W President and COO Jun 26, 2015 Sale $100.97 12,500 1,262,125 70,128 Jun 30, 2015, 05:39 PM
FOEHR MATTHEW W President and COO Jun 22, 2015 Option Exercise $9.97 25,046 249,709 91,174 Jun 24, 2015, 06:52 PM
FOEHR MATTHEW W President and COO Jun 22, 2015 Sale $96.45 23,046 2,222,815 86,628 Jun 24, 2015, 06:52 PM
Herman Melanie J Interim CFO Jun 10, 2015 Option Exercise $38.03 4,125 156,885 7,111 Jun 11, 2015, 06:17 PM
Herman Melanie J Interim CFO Jun 10, 2015 Sale $93.50 4,125 385,688 2,986 Jun 11, 2015, 06:17 PM
HIGGINS JOHN L Chief Executive Officer Jun 09, 2015 Sale $92.88 10,000 928,809 129,844 Jun 11, 2015, 06:13 PM
Aryeh Jason Director Jun 04, 2015 Sale $92.68 1,640 151,995 244,836 Jun 08, 2015, 08:43 PM
Aryeh Jason Director May 18, 2015 Sale $86.74 6,000 520,440 249,716 May 20, 2015, 05:28 PM
Aryeh Jason Director May 20, 2015 Sale $87.65 1,000 87,650 246,476 May 20, 2015, 05:28 PM
Aryeh Jason Director May 19, 2015 Sale $88.82 2,240 198,957 247,476 May 20, 2015, 05:28 PM
DeSilva Nishan M VP, Finance & Strategy and CFO May 13, 2015 Option Exercise $18.26 23,905 436,408 34,430 May 14, 2015, 05:39 PM
DeSilva Nishan M VP, Finance & Strategy and CFO May 12, 2015 Option Exercise $17.42 23,520 409,664 36,496 May 14, 2015, 05:39 PM
DeSilva Nishan M VP, Finance & Strategy and CFO May 14, 2015 Option Exercise $74.42 20,938 1,558,206 43,220 May 14, 2015, 05:39 PM
DeSilva Nishan M VP, Finance & Strategy and CFO May 12, 2015 Sale $84.63 23,520 1,990,403 22,282 May 14, 2015, 05:39 PM
DeSilva Nishan M VP, Finance & Strategy and CFO May 14, 2015 Sale $83.84 20,938 1,755,442 22,282 May 14, 2015, 05:39 PM
DeSilva Nishan M VP, Finance & Strategy and CFO May 13, 2015 Sale $83.27 23,905 1,990,671 22,282 May 14, 2015, 05:39 PM
Patel Sunil Director Mar 19, 2015 Sale $74.42 4,591 341,662 37,100 Mar 20, 2015, 04:44 PM
Berkman Charles S VP, Gen. Counsel & Secretary Mar 16, 2015 Option Exercise $20.32 5,264 106,939 30,119 Mar 18, 2015, 04:32 PM
Berkman Charles S VP, Gen. Counsel & Secretary Mar 16, 2015 Sale $74.54 11,264 839,649 25,989 Mar 18, 2015, 04:32 PM
Berkman Charles S VP, Gen. Counsel & Secretary Dec 31, 2014 Option Exercise $45.23 126 5,699 27,433 Mar 18, 2015, 04:28 PM
Herman Melanie J Director of Accounting Mar 02, 2015 Sale $60.69 535 32,469 2,986 Mar 03, 2015, 04:04 PM
Herman Melanie J Director of Accounting Dec 31, 2014 Option Exercise $45.23 103 4,659 2,831 Feb 25, 2015, 06:00 PM
Herman Melanie J Director of Accounting Feb 19, 2015 Sale $57.84 510 29,498 3,521 Feb 20, 2015, 04:49 PM
DeSilva Nishan M VP, Corporate Development Feb 10, 2015 Sale $56.34 2,300 129,582 16,359 Feb 11, 2015, 08:06 PM
Berkman Charles S VP, Gen. Counsel & Secretary Dec 31, 2014 Buy $45.23 126 5,699 27,433 Jan 05, 2015, 07:47 PM
FOEHR MATTHEW W EVP and COO Dec 31, 2014 Buy $45.23 46 2,081 55,016 Jan 05, 2015, 07:46 PM
Herman Melanie J Director of Accounting Dec 31, 2014 Buy $45.23 103 4,659 2,831 Jan 05, 2015, 07:46 PM
KOZARICH JOHN W Director Oct 15, 2014 Buy $45.68 2,000 91,360 49,286 Oct 15, 2014, 07:02 PM
FOEHR MATTHEW W EVP and COO Oct 13, 2014 Option Exercise $9.97 1,000 9,970 54,970 Oct 14, 2014, 01:48 PM
FOEHR MATTHEW W EVP and COO Oct 10, 2014 Buy $44.91 85 3,817 53,970 Oct 14, 2014, 01:48 PM
Sabba Stephen L Director Oct 09, 2014 Buy $43.12 2,000 86,230 23,697 Oct 14, 2014, 01:03 PM
KNOTT DAVID M Director Oct 09, 2014 Buy $43.01 4,000 172,029 69,227 Oct 14, 2014, 01:03 PM
Sabba Stephen L Director Oct 09, 2014 Option Exercise $43.12 2,000 86,230 23,697 Oct 10, 2014, 03:03 PM
KNOTT DAVID M Director Oct 09, 2014 Option Exercise $43.01 4,000 172,029 69,227 Oct 10, 2014, 02:29 PM
Aryeh Jason Director Oct 09, 2014 Buy $42.99 11,000 472,890 255,716 Oct 09, 2014, 07:04 PM
KOZARICH JOHN W Director Oct 07, 2014 Option Exercise $8.58 2,500 21,450 47,286 Oct 09, 2014, 01:50 PM
Aryeh Jason Director Oct 01, 2014 Option Exercise $32.30 7,335 236,920 60,695 Oct 01, 2014, 06:24 PM
Aryeh Jason Director Sep 25, 2014 Option Exercise $11.65 20,300 236,584 53,360 Sep 29, 2014, 01:50 PM
HIGGINS JOHN L President & CEO Aug 15, 2014 Buy $54.97 1,000 54,970 120,099 Aug 15, 2014, 02:51 PM
Herman Melanie J Director of Accounting Jun 30, 2014 Buy $43.79 98 4,292 2,728 Jul 01, 2014, 12:16 PM
Berkman Charles S VP, Gen. Counsel & Secretary Jun 30, 2014 Buy $43.79 329 14,408 27,307 Jul 01, 2014, 12:16 PM
FOEHR MATTHEW W EVP and COO Jun 30, 2014 Buy $43.79 428 18,743 53,885 Jul 01, 2014, 12:16 PM
Herman Melanie J Director of Accounting Jun 09, 2014 Option Exercise $12.49 1,100 13,741 3,480 Jun 10, 2014, 04:29 PM
Herman Melanie J Director of Accounting Jun 09, 2014 Sale $69.68 1,100 76,648 2,630 Jun 10, 2014, 04:29 PM
Berkman Charles S VP, Gen. Counsel & Secretary May 27, 2014 Option Exercise $18.81 2,499 47,007 28,644 May 28, 2014, 06:03 PM
Berkman Charles S VP, Gen. Counsel & Secretary May 27, 2014 Sale $66.90 7,166 479,434 26,978 May 28, 2014, 06:03 PM
BVF PARTNERS L P/IL See Explanation of Responses Mar 25, 2014 Sale $69.95 10,203 713,734 130,175 Mar 26, 2014, 07:28 PM
BVF PARTNERS L P/IL See Explanation of Responses Mar 25, 2014 Sale $69.95 18,019 1,260,489 230,125 Mar 26, 2014, 07:28 PM
BVF PARTNERS L P/IL See Explanation of Responses Mar 24, 2014 Sale $70.17 18,306 1,284,483 140,378 Mar 26, 2014, 07:28 PM
BVF PARTNERS L P/IL See Explanation of Responses Mar 24, 2014 Sale $70.17 31,698 2,224,163 248,144 Mar 26, 2014, 07:28 PM
Davis Todd C Director Mar 19, 2014 Sale $79.63 5,000 398,147 32,536 Mar 20, 2014, 06:40 PM
Davis Todd C Director Mar 18, 2014 Sale $79.45 2,500 198,637 37,536 Mar 20, 2014, 06:40 PM
LAMATTINA JOHN L Director Mar 18, 2014 Option Exercise $8.97 5,000 44,850 26,356 Mar 20, 2014, 06:40 PM
LAMATTINA JOHN L Director Mar 18, 2014 Sale $78.83 5,000 394,150 21,356 Mar 20, 2014, 06:40 PM
Sabba Stephen L Director Feb 27, 2014 Sale $72.25 500 36,125 20,546 Feb 28, 2014, 11:37 AM
KNOTT DAVID M Director Feb 20, 2014 Sale $72.97 900 65,676 1,843 Feb 21, 2014, 10:43 AM
BVF PARTNERS L P/IL 10% Owner Feb 18, 2014 Sale $74.66 14,003 1,045,409 87,520 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 19, 2014 Sale $73.03 2,771 202,375 84,749 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 20, 2014 Sale $73.05 5,359 391,464 79,390 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 18, 2014 Sale $74.66 153,751 11,478,450 1,855,083 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 19, 2014 Sale $73.03 57,370 4,189,921 1,797,713 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 20, 2014 Sale $73.05 112,369 8,208,319 1,685,344 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 18, 2014 Sale $74.66 16,331 1,219,209 174,636 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 19, 2014 Sale $73.03 5,395 394,015 169,241 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 20, 2014 Sale $73.05 10,557 771,167 158,684 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 18, 2014 Sale $74.66 16,915 1,262,808 307,921 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 19, 2014 Sale $73.03 9,464 691,187 298,457 Feb 20, 2014, 08:00 PM
BVF PARTNERS L P/IL 10% Owner Feb 20, 2014 Sale $73.05 18,615 1,359,787 279,842 Feb 20, 2014, 08:00 PM
KNOTT DAVID M Director Feb 18, 2014 Sale $73.31 3,900 285,919 40,796 Feb 19, 2014, 12:16 PM
KNOTT DAVID M Director Feb 18, 2014 Sale $73.31 11,531 845,368 233,361 Feb 19, 2014, 12:16 PM
KNOTT DAVID M Director Feb 14, 2014 Sale $77.10 6,700 516,583 44,696 Feb 19, 2014, 12:16 PM
KNOTT DAVID M Director Feb 14, 2014 Sale $77.10 19,769 1,524,229 244,892 Feb 19, 2014, 12:16 PM
Aryeh Jason Director Feb 14, 2014 Sale $78.87 9,500 749,265 244,716 Feb 14, 2014, 08:20 PM
Aryeh Jason Director Feb 13, 2014 Sale $77.43 6,700 518,779 254,216 Feb 14, 2014, 08:20 PM
Aryeh Jason Director Feb 12, 2014 Sale $75.21 24,120 1,814,121 260,916 Feb 14, 2014, 08:20 PM
Sharp John P VP Finance and CFO Feb 12, 2014 Option Exercise $17.57 86,953 1,528,059 34,333 Feb 14, 2014, 08:18 PM
Sharp John P VP Finance and CFO Feb 12, 2014 Sale $74.74 86,953 6,498,898 17,667 Feb 14, 2014, 08:18 PM
Berkman Charles S VP, Gen. Counsel & Secretary Feb 13, 2014 Option Exercise $14.47 2,000 28,940 31,645 Feb 14, 2014, 08:06 PM
Berkman Charles S VP, Gen. Counsel & Secretary Feb 12, 2014 Option Exercise $16.18 14,881 240,784 34,424 Feb 14, 2014, 08:06 PM
Berkman Charles S VP, Gen. Counsel & Secretary Feb 12, 2014 Sale $74.50 14,881 1,108,635 29,645 Feb 14, 2014, 08:06 PM
HIGGINS JOHN L President & CEO Feb 12, 2014 Option Exercise $9.96 16,875 168,075 127,974 Feb 14, 2014, 08:04 PM
HIGGINS JOHN L President & CEO Feb 12, 2014 Sale $75.00 16,875 1,265,625 111,099 Feb 14, 2014, 08:04 PM
FOEHR MATTHEW W EVP and COO Feb 14, 2014 Option Exercise $9.97 25,944 258,662 75,957 Feb 14, 2014, 08:00 PM
FOEHR MATTHEW W EVP and COO Feb 14, 2014 Sale $79.54 22,500 1,789,650 53,457 Feb 14, 2014, 08:00 PM
HIGGINS JOHN L President & CEO Jan 21, 2014 Option Exercise $21.00 9,000 189,000 111,099 Jan 21, 2014, 08:04 PM
HIGGINS JOHN L President & CEO Jan 16, 2014 Sale $64.00 15,000 960,000 102,099 Jan 21, 2014, 08:04 PM
FOEHR MATTHEW W EVP and COO Dec 31, 2013 Buy $33.92 84 2,849 45,013 Jan 02, 2014, 04:48 PM
Berkman Charles S VP, Gen. Counsel & Secretary Dec 31, 2013 Buy $33.92 209 7,088 27,145 Jan 02, 2014, 04:48 PM
Sharp John P VP Finance and CFO Dec 12, 2013 Option Exercise $9.96 700 6,972 18,367 Dec 16, 2013, 05:09 PM
Sharp John P VP Finance and CFO Dec 12, 2013 Sale $53.44 700 37,408 17,667 Dec 16, 2013, 05:09 PM
FOEHR MATTHEW W EVP and COO Dec 12, 2013 Option Exercise $9.97 6,000 59,820 50,929 Dec 13, 2013, 06:46 PM
FOEHR MATTHEW W EVP and COO Dec 12, 2013 Sale $53.40 6,000 320,400 44,929 Dec 13, 2013, 06:46 PM
Sharp John P VP Finance and CFO Dec 06, 2013 Sale $56.08 6,000 336,480 17,667 Dec 09, 2013, 06:53 PM
BVF PARTNERS L P/IL 10% Owner Nov 26, 2013 Sale $57.57 208,500 12,003,345 411,271 Nov 29, 2013, 11:38 AM
BVF PARTNERS L P/IL 10% Owner Nov 27, 2013 Sale $57.07 319,005 18,207,114 2,008,834 Nov 29, 2013, 11:38 AM
KOZARICH JOHN W Director Nov 25, 2013 Option Exercise $7.11 1,243 8,833 42,969 Nov 27, 2013, 11:29 AM
KOZARICH JOHN W Director Nov 18, 2013 Option Exercise $14.86 460 6,836 41,726 Nov 20, 2013, 08:46 PM
Sharp John P VP Finance and CFO Nov 18, 2013 Option Exercise $9.96 624 6,215 24,790 Nov 20, 2013, 06:49 PM
Sharp John P VP Finance and CFO Nov 18, 2013 Sale $53.00 1,123 59,519 23,667 Nov 20, 2013, 06:49 PM
HIGGINS JOHN L President & CEO Oct 22, 2013 Option Exercise $16.14 10,518 169,763 117,099 Oct 22, 2013, 08:05 PM
HIGGINS JOHN L President & CEO Oct 18, 2013 Sale $55.00 10,000 550,000 106,581 Oct 22, 2013, 08:05 PM
BVF PARTNERS L P/IL 10% Owner Sep 23, 2013 Sale $44.50 359,023 15,976,524 530,410 Sep 25, 2013, 06:54 PM
KNOTT DAVID M Director Sep 12, 2013 Sale $46.78 160,000 7,484,080 51,396 Sep 13, 2013, 03:07 PM
Berkman Charles S VP, Gen. Counsel & Secretary Aug 30, 2013 Option Exercise $17.51 37,331 653,697 29,732 Sep 04, 2013, 07:10 PM
Berkman Charles S VP, Gen. Counsel & Secretary Aug 30, 2013 Sale $47.54 28,323 1,346,456 17,928 Sep 04, 2013, 07:10 PM
Sharp John P VP Finance and CFO Aug 16, 2013 Option Exercise $9.96 7,500 74,700 31,666 Aug 20, 2013, 06:44 PM
Sharp John P VP Finance and CFO Aug 16, 2013 Sale $42.75 7,500 320,619 24,166 Aug 20, 2013, 06:44 PM
Berkman Charles S VP, Gen. Counsel & Secretary Aug 16, 2013 Option Exercise $9.96 14,583 145,247 28,227 Aug 20, 2013, 06:44 PM
Berkman Charles S VP, Gen. Counsel & Secretary Aug 19, 2013 Option Exercise $10.05 4,284 43,054 17,928 Aug 20, 2013, 06:44 PM
Berkman Charles S VP, Gen. Counsel & Secretary Aug 16, 2013 Sale $42.63 14,583 621,732 13,644 Aug 20, 2013, 06:44 PM
HIGGINS JOHN L President & CEO Aug 19, 2013 Option Exercise $16.14 6,556 105,814 116,581 Aug 20, 2013, 06:44 PM
HIGGINS JOHN L President & CEO Aug 16, 2013 Sale $42.85 10,000 428,500 110,025 Aug 20, 2013, 06:44 PM
DeSilva Nishan M VP, Corporate Development Jun 28, 2013 Buy $17.36 169 2,934 15,659 Jul 01, 2013, 03:27 PM
FOEHR MATTHEW W EVP and COO Jun 28, 2013 Buy $17.36 1,059 18,384 44,929 Jul 01, 2013, 03:27 PM
Berkman Charles S VP, Gen. Counsel & Secretary Jun 28, 2013 Buy $17.36 815 14,148 13,644 Jul 01, 2013, 03:26 PM
Berkman Charles S VP, Gen. Counsel & Secretary May 10, 2013 Sale $26.66 4,000 106,640 12,829 May 13, 2013, 06:46 PM
BVF PARTNERS L P/IL 10% Owner Jan 23, 2013 Buy $19.78 39,600 783,181 2,163,412 Jan 25, 2013, 05:17 PM
DeSilva Nishan M VP, Corporate Development Dec 31, 2012 Option Exercise $14.53 490 7,122 10,490 Jan 03, 2013, 08:27 PM
KOZARICH JOHN W Director Dec 21, 2012 Option Exercise $12.06 3,333 40,196 36,948 Dec 21, 2012, 05:51 PM
BVF PARTNERS L P/IL 10% Owner Dec 14, 2012 Buy $18.63 5,386 100,365 2,123,812 Dec 18, 2012, 04:36 PM
BVF PARTNERS L P/IL 10% Owner Dec 06, 2012 Buy $17.94 50,100 898,959 2,118,426 Dec 10, 2012, 04:40 PM
FOEHR MATTHEW W EVP and COO Dec 05, 2012 Buy $17.99 370 6,656 37,870 Dec 05, 2012, 04:53 PM
HIGGINS JOHN L President & CEO Dec 05, 2012 Buy $18.03 2,000 36,060 112,025 Dec 05, 2012, 04:53 PM
KNOTT DAVID M Director Nov 30, 2012 Sale $19.71 6,652 131,111 211,396 Dec 03, 2012, 02:13 PM
KNOTT DAVID M Director Nov 29, 2012 Sale $20.00 13,348 266,960 218,048 Dec 03, 2012, 02:13 PM
KNOTT DAVID M Director Nov 28, 2012 Sale $19.51 35,000 682,850 231,396 Nov 29, 2012, 03:04 PM
KNOTT DAVID M Director Nov 27, 2012 Sale $19.55 65,000 1,270,750 266,396 Nov 29, 2012, 03:04 PM
BVF PARTNERS L P/IL 10% Owner Oct 31, 2012 Buy $14.99 4,076 61,096 741,627 Nov 19, 2012, 05:24 PM
BVF PARTNERS L P/IL 10% Owner Oct 26, 2012 Buy $15.26 12,515 190,926 737,551 Nov 19, 2012, 05:24 PM
KNOTT DAVID M Director Aug 29, 2012 Buy $16.36 2,743 44,875 2,743 Nov 15, 2012, 06:11 PM
BVF PARTNERS L P/IL 10% Owner Oct 31, 2012 Buy $14.99 4,076 61,096 741,627 Nov 02, 2012, 06:36 PM
BVF PARTNERS L P/IL 10% Owner Oct 26, 2012 Buy $15.26 12,515 190,926 737,551 Nov 02, 2012, 06:36 PM
Berkman Charles S VP, Gen. Counsel & Secretary Sep 07, 2012 Sale $18.77 4,249 79,754 14,329 Sep 10, 2012, 01:55 PM
HIGGINS JOHN L President & CEO Aug 13, 2012 Buy $16.39 500 8,195 110,025 Aug 14, 2012, 07:19 PM
HIGGINS JOHN L President & CEO Jun 29, 2012 Option Exercise $10.12 1,250 12,654 109,525 Jul 03, 2012, 05:47 PM
FOEHR MATTHEW W EVP and COO Jun 29, 2012 Option Exercise $10.12 1,250 12,654 37,500 Jul 03, 2012, 05:46 PM
Berkman Charles S VP, Gen. Counsel & Secretary Jun 29, 2012 Option Exercise $10.12 1,250 12,654 18,578 Jul 03, 2012, 05:46 PM
Aryeh Jason Director Jun 01, 2012 Buy $11.98 700 8,386 285,036 Jun 05, 2012, 12:56 PM
Sabba Stephen L Director Jun 01, 2012 Option Exercise $12.02 2,000 24,040 17,425 Jun 04, 2012, 08:28 PM
KNOTT DAVID M Director May 24, 2012 Buy $11.62 23,900 277,718 264,661 May 25, 2012, 01:50 PM
KNOTT DAVID M Director May 24, 2012 Buy $11.62 172,100 1,999,802 972,100 May 25, 2012, 01:50 PM
KNOTT DAVID M Director May 24, 2012 Sale $11.62 76,167 885,061 331,396 May 25, 2012, 01:50 PM
KNOTT DAVID M Director May 24, 2012 Sale $11.62 98,633 1,146,115 0 May 25, 2012, 01:50 PM
KNOTT DAVID M Director May 24, 2012 Sale $11.62 21,200 246,344 41,583 May 25, 2012, 01:50 PM
Patel Sunil Director May 23, 2012 Buy $11.38 1,500 17,070 29,705 May 24, 2012, 02:01 PM
HIGGINS JOHN L President & CEO May 04, 2012 Buy $12.04 1,000 12,040 108,275 May 08, 2012, 01:54 PM
Berkman Charles S VP, Gen. Counsel & Secretary Mar 08, 2012 Sale $15.76 3,606 56,832 17,434 Mar 08, 2012, 06:24 PM
HIGGINS JOHN L President & CEO Dec 30, 2011 Option Exercise $10.09 210 2,119 89,275 Jan 06, 2012, 05:21 PM
FOEHR MATTHEW W EVP and COO Dec 30, 2011 Option Exercise $10.09 1,250 12,612 26,250 Jan 06, 2012, 05:20 PM
Berkman Charles S VP, Gen. Counsel & Secretary Dec 30, 2011 Option Exercise $10.09 1,238 12,491 15,934 Jan 06, 2012, 05:19 PM
BVF PARTNERS L P/IL 10% Owner Nov 18, 2011 Buy $11.01 72,669 799,795 1,788,226 Nov 22, 2011, 04:29 PM
BVF PARTNERS L P/IL 10% Owner Nov 21, 2011 Buy $10.59 340,200 3,602,718 2,068,326 Nov 22, 2011, 04:29 PM
BVF PARTNERS L P/IL 10% Owner Nov 21, 2011 Buy $10.59 98,171 1,039,631 725,036 Nov 22, 2011, 04:29 PM
KOZARICH JOHN W Director Nov 11, 2011 Buy $11.79 1,000 11,787 27,098 Nov 14, 2011, 07:00 PM
Sabba Stephen L Director Nov 10, 2011 Buy $11.69 1,000 11,690 11,704 Nov 14, 2011, 06:31 PM
Sabba Stephen L Director Nov 14, 2011 Buy $11.50 1,000 11,500 12,704 Nov 14, 2011, 06:31 PM
KNOTT DAVID M Director Nov 10, 2011 Buy $11.58 4,000 46,320 54,704 Nov 14, 2011, 06:29 PM
Aryeh Jason Director Nov 10, 2011 Buy $10.90 1,000 10,900 5,025 Nov 10, 2011, 07:28 PM
Aryeh Jason Director Nov 10, 2011 Buy $11.01 1,000 11,010 284,336 Nov 10, 2011, 07:28 PM
Patel Sunil Director Nov 10, 2011 Buy $11.11 2,500 27,774 28,205 Nov 10, 2011, 07:20 PM
BVF PARTNERS L P/IL 10% Owner Oct 26, 2011 Buy $13.91 6,020 83,751 1,741,800 Oct 28, 2011, 04:55 PM
BVF PARTNERS L P/IL 10% Owner Oct 21, 2011 Buy $13.93 4,600 64,062 1,738,000 Oct 25, 2011, 04:22 PM
BVF PARTNERS L P/IL 10% Owner Oct 20, 2011 Buy $13.93 11,900 165,809 1,735,000 Oct 20, 2011, 05:40 PM
BVF PARTNERS L P/IL 10% Owner Oct 18, 2011 Buy $13.73 2,200 30,215 1,727,400 Oct 20, 2011, 05:40 PM
BVF PARTNERS L P/IL 10% Owner Oct 13, 2011 Buy $13.55 17,258 233,880 1,726,000 Oct 14, 2011, 04:16 PM
BVF PARTNERS L P/IL 10% Owner Oct 13, 2011 Buy $13.55 4,995 67,692 605,053 Oct 14, 2011, 04:16 PM
BVF PARTNERS L P/IL 10% Owner Oct 12, 2011 Buy $13.69 53,100 726,992 1,711,762 Oct 14, 2011, 04:16 PM
BVF PARTNERS L P/IL 10% Owner Oct 04, 2011 Buy $12.78 14,400 183,961 1,675,562 Oct 06, 2011, 05:02 PM
KNOTT DAVID M Director Sep 01, 2011 Buy $15.21 2,480 37,721 407,563 Sep 06, 2011, 04:59 PM
KNOTT DAVID M Director Sep 01, 2011 Buy $15.21 700 10,647 98,633 Sep 06, 2011, 04:59 PM
KNOTT DAVID M Director Sep 01, 2011 Buy $15.21 1,500 22,815 240,761 Sep 06, 2011, 04:59 PM
KNOTT DAVID M Director Sep 01, 2011 Buy $15.21 5,320 80,917 800,000 Sep 06, 2011, 04:59 PM
KNOTT DAVID M Director Aug 31, 2011 Buy $14.94 600 8,964 405,083 Sep 01, 2011, 01:26 PM
KNOTT DAVID M Director Aug 30, 2011 Buy $14.83 1,640 24,321 404,483 Sep 01, 2011, 01:26 PM
KNOTT DAVID M Director Aug 31, 2011 Buy $14.94 200 2,988 97,933 Sep 01, 2011, 01:26 PM
KNOTT DAVID M Director Aug 30, 2011 Buy $14.83 700 10,381 97,733 Sep 01, 2011, 01:26 PM
KNOTT DAVID M Director Aug 31, 2011 Buy $14.94 500 7,470 239,261 Sep 01, 2011, 01:26 PM
KNOTT DAVID M Director Aug 30, 2011 Buy $14.83 1,400 20,762 238,761 Sep 01, 2011, 01:26 PM
KNOTT DAVID M Director Aug 31, 2011 Buy $14.94 1,700 25,398 794,680 Sep 01, 2011, 01:26 PM
KNOTT DAVID M Director Aug 30, 2011 Buy $14.83 5,200 77,116 792,980 Sep 01, 2011, 01:26 PM
KNOTT DAVID M Director Aug 26, 2011 Buy $12.54 11,159 139,934 397,543 Aug 30, 2011, 05:00 PM
KNOTT DAVID M Director Aug 29, 2011 Buy $14.21 5,300 75,313 402,843 Aug 30, 2011, 05:00 PM
KNOTT DAVID M Director Aug 26, 2011 Buy $12.54 2,600 32,604 95,833 Aug 30, 2011, 05:00 PM
KNOTT DAVID M Director Aug 29, 2011 Buy $14.21 1,200 17,052 97,033 Aug 30, 2011, 05:00 PM
KNOTT DAVID M Director Aug 26, 2011 Buy $12.54 6,600 82,764 234,261 Aug 30, 2011, 05:00 PM
KNOTT DAVID M Director Aug 29, 2011 Buy $14.21 3,100 44,051 237,361 Aug 30, 2011, 05:00 PM
KNOTT DAVID M Director Aug 26, 2011 Buy $12.54 21,200 265,848 777,380 Aug 30, 2011, 05:00 PM
KNOTT DAVID M Director Aug 29, 2011 Buy $14.21 10,400 147,784 787,780 Aug 30, 2011, 05:00 PM
KNOTT DAVID M Director Aug 25, 2011 Buy $12.57 19,600 246,372 756,180 Aug 26, 2011, 05:48 PM
KNOTT DAVID M Director Aug 25, 2011 Buy $12.57 17,200 216,204 62,783 Aug 26, 2011, 05:48 PM
KNOTT DAVID M Director Aug 25, 2011 Buy $12.57 9,900 124,443 386,384 Aug 26, 2011, 05:48 PM
KNOTT DAVID M Director Aug 25, 2011 Buy $12.57 2,500 31,425 93,233 Aug 26, 2011, 05:48 PM
KNOTT DAVID M Director Aug 25, 2011 Buy $12.57 5,800 72,906 227,661 Aug 26, 2011, 05:48 PM
KNOTT DAVID M Director Aug 23, 2011 Buy $12.18 1,200 14,616 89,833 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 24, 2011 Buy $12.95 900 11,655 90,733 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 23, 2011 Buy $12.18 3,100 37,758 219,471 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 24, 2011 Buy $12.95 2,390 30,950 221,861 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 24, 2011 Buy $12.95 2,600 33,670 28,300 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 23, 2011 Buy $12.18 10,300 125,454 729,080 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 24, 2011 Buy $12.95 7,500 97,125 736,580 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 24, 2011 Buy $12.95 4,100 53,095 45,583 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 23, 2011 Buy $12.18 5,400 65,772 372,484 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 24, 2011 Buy $12.95 4,000 51,800 376,484 Aug 25, 2011, 04:41 PM
KNOTT DAVID M Director Aug 19, 2011 Buy $11.96 1,800 21,528 88,433 Aug 24, 2011, 06:16 AM
KNOTT DAVID M Director Aug 22, 2011 Buy $12.00 200 2,400 88,633 Aug 24, 2011, 06:16 AM
KNOTT DAVID M Director Aug 22, 2011 Buy $12.00 500 6,000 216,371 Aug 24, 2011, 06:16 AM
KNOTT DAVID M Director Aug 19, 2011 Buy $11.96 4,300 51,428 215,871 Aug 24, 2011, 06:16 AM
KNOTT DAVID M Director Aug 22, 2011 Buy $12.00 1,700 20,400 718,780 Aug 24, 2011, 06:16 AM
KNOTT DAVID M Director Aug 19, 2011 Buy $11.96 14,300 171,028 717,080 Aug 24, 2011, 06:16 AM
KNOTT DAVID M Director Aug 19, 2011 Buy $11.96 7,400 88,504 366,015 Aug 24, 2011, 06:16 AM
KNOTT DAVID M Director Aug 22, 2011 Buy $12.00 1,069 12,828 367,084 Aug 24, 2011, 06:16 AM
BVF PARTNERS L P/IL 10% Owner Aug 18, 2011 Buy $11.91 16,571 197,371 1,652,562 Aug 22, 2011, 06:05 PM
BVF PARTNERS L P/IL 10% Owner Aug 19, 2011 Buy $11.93 21,300 254,020 1,671,562 Aug 22, 2011, 06:05 PM
KNOTT DAVID M Director Aug 17, 2011 Buy $12.35 4,200 51,870 694,380 Aug 19, 2011, 03:49 PM
KNOTT DAVID M Director Aug 18, 2011 Buy $11.91 8,400 100,044 702,780 Aug 19, 2011, 03:49 PM
KNOTT DAVID M Director Aug 17, 2011 Buy $12.35 2,133 26,343 354,515 Aug 19, 2011, 03:49 PM
KNOTT DAVID M Director Aug 18, 2011 Buy $11.91 4,100 48,831 358,615 Aug 19, 2011, 03:49 PM
KNOTT DAVID M Director Aug 17, 2011 Buy $12.35 600 7,410 85,633 Aug 19, 2011, 03:49 PM
KNOTT DAVID M Director Aug 18, 2011 Buy $11.91 1,000 11,910 86,633 Aug 19, 2011, 03:49 PM
KNOTT DAVID M Director Aug 17, 2011 Buy $12.35 1,200 14,820 209,071 Aug 19, 2011, 03:49 PM
KNOTT DAVID M Director Aug 18, 2011 Buy $11.91 2,500 29,775 211,571 Aug 19, 2011, 03:49 PM
BVF PARTNERS L P/IL 10% Owner Aug 11, 2011 Buy $11.19 1,394 15,601 1,636,862 Aug 15, 2011, 06:24 PM
KNOTT DAVID M Director Aug 12, 2011 Buy $11.99 2,200 26,378 207,171 Aug 15, 2011, 06:00 PM
KNOTT DAVID M Director Aug 15, 2011 Buy $11.97 700 8,379 207,871 Aug 15, 2011, 06:00 PM
KNOTT DAVID M Director Aug 12, 2011 Buy $11.99 7,300 87,527 687,780 Aug 15, 2011, 06:00 PM
KNOTT DAVID M Director Aug 15, 2011 Buy $11.97 2,400 28,728 690,180 Aug 15, 2011, 06:00 PM
KNOTT DAVID M Director Aug 12, 2011 Buy $11.99 3,448 41,342 351,182 Aug 15, 2011, 06:00 PM
KNOTT DAVID M Director Aug 15, 2011 Buy $11.97 1,200 14,364 352,382 Aug 15, 2011, 06:00 PM
KNOTT DAVID M Director Aug 12, 2011 Buy $11.99 800 9,592 84,733 Aug 15, 2011, 06:00 PM
KNOTT DAVID M Director Aug 15, 2011 Buy $11.97 300 3,591 85,033 Aug 15, 2011, 06:00 PM
KNOTT DAVID M Director Aug 10, 2011 Buy $10.80 7,400 79,920 82,433 Aug 12, 2011, 04:13 PM
KNOTT DAVID M Director Aug 11, 2011 Buy $11.45 3,900 44,655 204,971 Aug 12, 2011, 04:13 PM
KNOTT DAVID M Director Aug 10, 2011 Buy $10.80 24,500 264,600 201,071 Aug 12, 2011, 04:13 PM
KNOTT DAVID M Director Aug 11, 2011 Buy $11.45 12,700 145,415 680,480 Aug 12, 2011, 04:13 PM
KNOTT DAVID M Director Aug 10, 2011 Buy $10.80 80,600 870,480 667,780 Aug 12, 2011, 04:13 PM
KNOTT DAVID M Director Aug 10, 2011 Buy $10.80 5,600 60,480 25,700 Aug 12, 2011, 04:13 PM
KNOTT DAVID M Director Aug 11, 2011 Buy $11.45 1,900 21,755 347,734 Aug 12, 2011, 04:13 PM
KNOTT DAVID M Director Aug 10, 2011 Buy $10.80 6,900 74,520 41,483 Aug 12, 2011, 04:13 PM
KNOTT DAVID M Director Aug 11, 2011 Buy $11.45 1,500 17,175 83,933 Aug 12, 2011, 04:13 PM
Davis Todd C Director Aug 10, 2011 Buy $10.90 15,000 163,500 29,201 Aug 11, 2011, 08:08 PM
Patel Sunil Director Aug 10, 2011 Buy $10.74 5,000 53,705 25,705 Aug 11, 2011, 06:00 PM
Aryeh Jason Director Aug 10, 2011 Buy $10.57 2,000 21,140 283,336 Aug 11, 2011, 02:20 PM
BVF PARTNERS L P/IL 10% Owner Aug 09, 2011 Buy $10.86 57,900 629,026 527,236 Aug 10, 2011, 06:28 PM
BVF PARTNERS L P/IL 10% Owner Aug 08, 2011 Buy $11.20 175,800 1,969,663 1,354,736 Aug 10, 2011, 06:28 PM
BVF PARTNERS L P/IL 10% Owner Aug 10, 2011 Buy $10.91 233,000 2,542,659 1,635,936 Aug 10, 2011, 06:28 PM
BVF PARTNERS L P/IL 10% Owner Aug 09, 2011 Buy $10.86 133,000 1,444,912 1,487,736 Aug 10, 2011, 06:28 PM
HIGGINS JOHN L President & CEO Jun 30, 2011 Option Exercise $7.64 277 2,116 89,065 Jul 26, 2011, 06:02 PM
HIGGINS JOHN L President & CEO Dec 31, 2010 Option Exercise $7.14 294 2,099 73,788 Jul 26, 2011, 06:02 PM
Aryeh Jason Director May 12, 2011 Buy $10.96 1,725 18,906 281,336 May 13, 2011, 05:45 PM
Aryeh Jason Director Mar 11, 2011 Buy $9.83 1,000 9,830 3,025 May 13, 2011, 05:41 PM
Aryeh Jason Director Mar 11, 2011 Buy $9.84 3,000 29,525 270,111 May 13, 2011, 05:41 PM
Aryeh Jason Director Mar 15, 2011 Buy $9.49 1,500 14,235 272,611 Mar 16, 2011, 07:14 PM
Aryeh Jason Director Mar 16, 2011 Buy $9.35 4,000 37,405 276,611 Mar 16, 2011, 07:14 PM
Aryeh Jason Director Mar 14, 2011 Buy $9.69 3,500 33,900 271,111 Mar 15, 2011, 01:22 PM
LAMATTINA JOHN L Director Mar 11, 2011 Buy $9.80 10,000 98,030 11,666 Mar 14, 2011, 04:12 PM
Aryeh Jason Director Mar 10, 2011 Buy $10.16 500 5,080 267,611 Mar 14, 2011, 03:24 PM
Aryeh Jason Director Mar 10, 2011 Buy $10.05 1,000 10,045 3,025 Mar 14, 2011, 03:24 PM
KNOTT DAVID M Director Mar 03, 2011 Buy $11.02 13,400 147,668 20,100 Mar 07, 2011, 05:45 PM
KNOTT DAVID M Director Mar 03, 2011 Buy $11.02 23,000 253,460 34,583 Mar 07, 2011, 05:45 PM
KNOTT DAVID M Director Mar 03, 2011 Buy $11.02 1,000 11,020 1,666 Mar 07, 2011, 05:45 PM
KOZARICH JOHN W Director Feb 25, 2011 Buy $9.99 1,789 17,872 18,726 Mar 03, 2011, 01:59 PM
KOZARICH JOHN W Director Feb 24, 2011 Buy $9.98 3,211 32,056 16,937 Mar 03, 2011, 01:59 PM
Kazmi Syed VP, Bus. Dev. & Strategic Plan Feb 28, 2011 Sale $10.69 1,166 12,459 15,296 Mar 01, 2011, 03:06 PM
KOZARICH JOHN W Director Feb 24, 2011 Option Exercise $9.98 3,211 32,056 16,937 Feb 28, 2011, 07:05 PM
KOZARICH JOHN W Director Feb 25, 2011 Option Exercise $9.99 1,789 17,872 18,726 Feb 28, 2011, 07:05 PM
KNOTT DAVID M Director Feb 24, 2011 Buy $9.99 16,316 162,997 18,816 Feb 28, 2011, 04:19 PM
KNOTT DAVID M Director Feb 28, 2011 Buy $10.84 9,252 100,292 42,500 Feb 28, 2011, 04:19 PM
KNOTT DAVID M Director Feb 25, 2011 Buy $10.02 14,432 144,609 33,248 Feb 28, 2011, 04:19 PM
KNOTT DAVID M Director Feb 23, 2011 Buy $9.95 21,400 212,930 75,033 Feb 25, 2011, 01:46 PM
KNOTT DAVID M Director Feb 23, 2011 Buy $9.99 6,700 66,933 6,700 Feb 25, 2011, 01:46 PM
KNOTT DAVID M Director Feb 23, 2011 Buy $9.95 2,200 21,890 176,571 Feb 25, 2011, 01:46 PM
KNOTT DAVID M Director Feb 23, 2011 Buy $9.95 65,200 648,740 587,180 Feb 25, 2011, 01:46 PM
KNOTT DAVID M Director Feb 23, 2011 Sale $9.95 47,087 468,516 345,834 Feb 25, 2011, 01:46 PM
KNOTT DAVID M Director Feb 23, 2011 Sale $9.95 31,331 311,743 0 Feb 25, 2011, 01:46 PM
KNOTT DAVID M Director Feb 23, 2011 Sale $9.95 10,382 103,301 0 Feb 25, 2011, 01:46 PM
Aryeh Jason Director Feb 23, 2011 Buy $9.94 5,000 49,700 267,111 Feb 23, 2011, 05:02 PM
Berkman Charles S VP, Gen. Counsel & Secretary Feb 16, 2011 Sale $9.75 5,000 48,751 11,696 Feb 18, 2011, 05:38 PM
KOZARICH JOHN W Director Feb 17, 2011 Buy $9.90 1,000 9,900 13,726 Feb 17, 2011, 06:07 PM
Patel Sunil Director Feb 16, 2011 Buy $9.22 10,000 92,174 13,333 Feb 17, 2011, 01:57 PM
KOZARICH JOHN W Director Nov 11, 2010 Buy $1.60 10,000 15,954 76,357 Nov 12, 2010, 02:03 PM

Desktop Version

Owner Relationship Date Transaction Value($)
Aryeh Jason Director Jun 11, 2019 Buy 26,753
FOEHR MATTHEW W President and COO Jun 11, 2019 Option Exercise 22,008
HIGGINS JOHN L Chief Executive Officer May 31, 2019 Buy 108,202
Aryeh Jason Director May 31, 2019 Buy 54,255
Aryeh Jason Director May 30, 2019 Buy 27,503
Aryeh Jason Director May 29, 2019 Buy 27,753
Aryeh Jason Director May 20, 2019 Buy 28,003
Aryeh Jason Director May 14, 2019 Buy 28,128
HIGGINS JOHN L Chief Executive Officer May 14, 2019 Buy 283,750
KOZARICH JOHN W Director May 14, 2019 Option Exercise 44,700
KOZARICH JOHN W Director May 14, 2019 Sale 282,300
FOEHR MATTHEW W President and COO Mar 14, 2019 Option Exercise 148,493
Aryeh Jason Director Mar 13, 2019 Buy 22,727
HIGGINS JOHN L Chief Executive Officer Mar 13, 2019 Buy 285,725
FOEHR MATTHEW W President and COO Jan 23, 2019 Option Exercise 287,051
HIGGINS JOHN L Chief Executive Officer Jan 23, 2019 Option Exercise 756,192
Korenberg Matthew E EVP,Finance & Strategy and CFO Jan 23, 2019 Option Exercise 148,108
Berkman Charles S SVP, Gen. Counsel & Secretary Jan 10, 2019 Option Exercise 187,029
HIGGINS JOHN L Chief Executive Officer Jan 10, 2019 Option Exercise 545,371
Berkman Charles S SVP, Gen. Counsel & Secretary Dec 17, 2018 Option Exercise 74,528
FOEHR MATTHEW W President and COO Dec 12, 2018 Option Exercise 79,750
Berkman Charles S SVP, Gen. Counsel & Secretary Oct 24, 2018 Option Exercise 65,462
Davis Todd C Director Oct 12, 2018 Option Exercise 525,021
Berkman Charles S SVP, Gen. Counsel & Secretary Oct 11, 2018 Option Exercise 28,940
Davis Todd C Director Oct 08, 2018 Sale 634,978
KOZARICH JOHN W Director Oct 01, 2018 Sale 687,610
FOEHR MATTHEW W President and COO Oct 01, 2018 Option Exercise 194,457
FOEHR MATTHEW W President and COO Oct 01, 2018 Sale 3,286,560
Berkman Charles S SVP, Gen. Counsel & Secretary Sep 17, 2018 Option Exercise 282,369
Berkman Charles S SVP, Gen. Counsel & Secretary Sep 17, 2018 Sale 705,183
Sabba Stephen L Director Sep 04, 2018 Option Exercise 66,150
Sabba Stephen L Director Sep 04, 2018 Sale 1,275,250
FOEHR MATTHEW W President and COO Sep 04, 2018 Option Exercise 184,049
FOEHR MATTHEW W President and COO Sep 04, 2018 Sale 3,060,084
Berkman Charles S SVP, Gen. Counsel & Secretary Sep 04, 2018 Option Exercise 1,358,796
Berkman Charles S SVP, Gen. Counsel & Secretary Sep 04, 2018 Sale 4,951,063
LAMATTINA JOHN L Director Sep 04, 2018 Option Exercise 41,788
LAMATTINA JOHN L Director Sep 04, 2018 Sale 850,292
HIGGINS JOHN L Chief Executive Officer Aug 30, 2018 Sale 903,875
Korenberg Matthew E EVP,Finance & Strategy and CFO Aug 29, 2018 Option Exercise 990,017
Korenberg Matthew E EVP,Finance & Strategy and CFO Aug 29, 2018 Sale 4,712,058
Aryeh Jason Director Aug 17, 2018 Sale 6,495,554
Aryeh Jason Director Aug 16, 2018 Sale 264,600
Davis Todd C Director Aug 17, 2018 Sale 758,497
Davis Todd C Director Aug 16, 2018 Sale 1,399,506
HIGGINS JOHN L Chief Executive Officer Aug 17, 2018 Option Exercise 188,009
HIGGINS JOHN L Chief Executive Officer Aug 16, 2018 Option Exercise 43,511
HIGGINS JOHN L Chief Executive Officer Aug 17, 2018 Sale 3,157,299
HIGGINS JOHN L Chief Executive Officer Aug 16, 2018 Sale 5,190,263
Patel Sunil Director Aug 16, 2018 Option Exercise 451,058
Patel Sunil Director Aug 16, 2018 Sale 10,150,825
Korenberg Matthew E EVP,Finance & Strategy and CFO Aug 06, 2018 Option Exercise 189,555
KOZARICH JOHN W Director Jul 02, 2018 Sale 518,700
Korenberg Matthew E EVP,Finance & Strategy and CFO Jun 29, 2018 Option Exercise 21,210
Berkman Charles S SVP, Gen. Counsel & Secretary Jun 29, 2018 Option Exercise 21,210
LAMATTINA JOHN L Director Jun 04, 2018 Option Exercise 50,120
LAMATTINA JOHN L Director Jun 04, 2018 Sale 778,040
HIGGINS JOHN L Chief Executive Officer May 15, 2018 Option Exercise 200,217
HIGGINS JOHN L Chief Executive Officer May 15, 2018 Sale 2,232,491
FOEHR MATTHEW W President and COO May 10, 2018 Option Exercise 139,026
FOEHR MATTHEW W President and COO May 10, 2018 Sale 1,488,687
KOZARICH JOHN W Director Apr 02, 2018 Sale 401,063
Sabba Stephen L Director Mar 12, 2018 Sale 112,414
Aryeh Jason Director Mar 09, 2018 Sale 705,900
Aryeh Jason Director Mar 08, 2018 Sale 612,094
LAMATTINA JOHN L Director Mar 05, 2018 Option Exercise 33,750
LAMATTINA JOHN L Director Mar 05, 2018 Sale 536,605
Korenberg Matthew E EVP,Finance & Strategy and CFO Mar 06, 2018 Option Exercise 91,228
Berkman Charles S SVP, Gen. Counsel & Secretary Mar 06, 2018 Option Exercise 65,021
HIGGINS JOHN L Chief Executive Officer Mar 06, 2018 Option Exercise 494,624
FOEHR MATTHEW W President and COO Mar 06, 2018 Option Exercise 241,673
Aryeh Jason Director Feb 23, 2018 Sale 529,635
Davis Todd C Director Feb 27, 2018 Sale 1,873,711
Davis Todd C Director Feb 26, 2018 Sale 742,535
FOEHR MATTHEW W President and COO Feb 23, 2018 Option Exercise 88,785
FOEHR MATTHEW W President and COO Feb 23, 2018 Sale 832,823
Berkman Charles S SVP, Gen. Counsel & Secretary Feb 15, 2018 Option Exercise 162,838
FOEHR MATTHEW W President and COO Feb 15, 2018 Option Exercise 575,750
HIGGINS JOHN L Chief Executive Officer Feb 15, 2018 Option Exercise 981,118
HIGGINS JOHN L Chief Executive Officer Feb 15, 2018 Sale 1,413,279
Korenberg Matthew E EVP,Finance & Strategy and CFO Feb 15, 2018 Option Exercise 106,882
HIGGINS JOHN L Chief Executive Officer Jan 24, 2018 Sale 3,712,500
HIGGINS JOHN L Chief Executive Officer Jan 19, 2018 Option Exercise 262,259
HIGGINS JOHN L Chief Executive Officer Jan 19, 2018 Sale 4,318,906
KOZARICH JOHN W Director Jan 10, 2018 Sale 362,500
Korenberg Matthew E VP, Finance and CFO Dec 28, 2017 Option Exercise 212,150
FOEHR MATTHEW W President and COO Dec 28, 2017 Option Exercise 411,959
HIGGINS JOHN L Chief Executive Officer Dec 28, 2017 Option Exercise 720,893
Berkman Charles S VP, Gen. Counsel & Secretary Dec 28, 2017 Option Exercise 162,926
Sabba Stephen L Director Dec 20, 2017 Sale 126,956
Aryeh Jason Director Nov 17, 2017 Sale 3,421,368
HIGGINS JOHN L Chief Executive Officer Nov 17, 2017 Sale 316,888
LAMATTINA JOHN L Director Nov 17, 2017 Option Exercise 40,480
LAMATTINA JOHN L Director Nov 17, 2017 Sale 559,160
KOZARICH JOHN W Director Nov 16, 2017 Sale 708,550
Korenberg Matthew E VP, Finance and CFO Nov 17, 2017 Sale 935,510
HIGGINS JOHN L Chief Executive Officer Nov 16, 2017 Sale 750,991
HIGGINS JOHN L Chief Executive Officer Oct 13, 2017 Option Exercise 249,462
HIGGINS JOHN L Chief Executive Officer Oct 13, 2017 Option Exercise 249,537
HIGGINS JOHN L Chief Executive Officer Sep 05, 2017 Option Exercise 105,000
HIGGINS JOHN L Chief Executive Officer Sep 05, 2017 Sale 650,000
Aryeh Jason Director Aug 23, 2017 Sale 255,980
FOEHR MATTHEW W President and COO Aug 09, 2017 Option Exercise 69,292
FOEHR MATTHEW W President and COO Aug 09, 2017 Sale 777,823
Berkman Charles S VP, Gen. Counsel & Secretary Aug 09, 2017 Sale 2,364,667
HIGGINS JOHN L Chief Executive Officer Aug 08, 2017 Option Exercise 115,143
HIGGINS JOHN L Chief Executive Officer Aug 08, 2017 Sale 685,375
Korenberg Matthew E VP, Finance and CFO Aug 06, 2017 Option Exercise 74,335
Berkman Charles S VP, Gen. Counsel & Secretary Jun 30, 2017 Option Exercise 21,171
Korenberg Matthew E VP, Finance and CFO Jun 30, 2017 Option Exercise 21,171
HIGGINS JOHN L Chief Executive Officer Jun 21, 2017 Option Exercise 97,986
HIGGINS JOHN L Chief Executive Officer Jun 21, 2017 Sale 559,920
HIGGINS JOHN L Chief Executive Officer Jun 09, 2017 Option Exercise 252,000
HIGGINS JOHN L Chief Executive Officer Jun 09, 2017 Sale 1,378,440
FOEHR MATTHEW W President and COO May 12, 2017 Option Exercise 56,041
FOEHR MATTHEW W President and COO May 15, 2017 Option Exercise 21,934
FOEHR MATTHEW W President and COO May 12, 2017 Sale 630,648
Aryeh Jason Director May 12, 2017 Sale 1,631,332
Aryeh Jason Director May 11, 2017 Sale 2,494,034
HIGGINS JOHN L Chief Executive Officer Mar 20, 2017 Sale 436,400
HIGGINS JOHN L Chief Executive Officer Mar 08, 2017 Option Exercise 157,493
HIGGINS JOHN L Chief Executive Officer Mar 08, 2017 Option Exercise 157,534
HIGGINS JOHN L Chief Executive Officer Mar 08, 2017 Sale 428,240
FOEHR MATTHEW W President and COO Mar 03, 2017 Option Exercise 19,940
FOEHR MATTHEW W President and COO Mar 02, 2017 Option Exercise 68,584
FOEHR MATTHEW W President and COO Mar 02, 2017 Sale 711,213
Aryeh Jason Director Feb 28, 2017 Sale 753,060
Aryeh Jason Director Feb 27, 2017 Sale 2,650,000
Korenberg Matthew E VP, Finance and CFO Feb 24, 2017 Option Exercise 105,499
Korenberg Matthew E VP, Finance and CFO Feb 15, 2017 Option Exercise 40,773
Korenberg Matthew E VP, Finance and CFO Aug 06, 2016 Option Exercise 75,090
FOEHR MATTHEW W President and COO Feb 15, 2017 Option Exercise 246,831
FOEHR MATTHEW W President and COO Feb 24, 2017 Option Exercise 274,339
HIGGINS JOHN L Chief Executive Officer Feb 24, 2017 Option Exercise 480,118
HIGGINS JOHN L Chief Executive Officer Feb 15, 2017 Option Exercise 448,821
Korenberg Matthew E VP, Finance and CFO Dec 30, 2016 Option Exercise 3,455
Aryeh Jason Director Nov 25, 2016 Sale 372,007
Aryeh Jason Director Nov 22, 2016 Sale 1,611,062
Aryeh Jason Director Nov 16, 2016 Sale 141,419
Aryeh Jason Director Nov 18, 2016 Sale 525,000
Davis Todd C Director Oct 31, 2016 Option Exercise 638,362
HIGGINS JOHN L Chief Executive Officer Sep 22, 2016 Sale 352,020
KOZARICH JOHN W Director Sep 07, 2016 Sale 115,000
KOZARICH JOHN W Director Sep 01, 2016 Option Exercise 75,970
KOZARICH JOHN W Director Sep 01, 2016 Sale 175,597
FOEHR MATTHEW W President and COO Aug 08, 2016 Option Exercise 41,126
FOEHR MATTHEW W President and COO Aug 05, 2016 Option Exercise 124,625
FOEHR MATTHEW W President and COO Aug 05, 2016 Sale 1,526,750
Berkman Charles S VP, Gen. Counsel & Secretary Aug 05, 2016 Option Exercise 1,661,857
Berkman Charles S VP, Gen. Counsel & Secretary Aug 05, 2016 Sale 2,717,772
KOZARICH JOHN W Director Aug 01, 2016 Sale 137,569
Korenberg Matthew E VP, Finance and CFO Jun 30, 2016 Option Exercise 17,072
Herman Melanie J Director of Accounting Jun 30, 2016 Option Exercise 13,675
KOZARICH JOHN W Director Jul 01, 2016 Sale 121,402
KOZARICH JOHN W Director Jun 01, 2016 Sale 117,419
Herman Melanie J Director of Accounting May 18, 2016 Sale 40,247
Aryeh Jason Director May 06, 2016 Sale 1,777,830
Aryeh Jason Director May 05, 2016 Sale 1,202,120
KOZARICH JOHN W Director May 02, 2016 Sale 121,568
KOZARICH JOHN W Director Apr 06, 2016 Sale 575,000
FOEHR MATTHEW W President and COO Mar 17, 2016 Option Exercise 86,241
FOEHR MATTHEW W President and COO Mar 17, 2016 Sale 618,880
Aryeh Jason Director Mar 07, 2016 Sale 568,895
Aryeh Jason Director Mar 08, 2016 Sale 51,245
HIGGINS JOHN L Chief Executive Officer Mar 08, 2016 Option Exercise 126,000
HIGGINS JOHN L Chief Executive Officer Mar 07, 2016 Sale 1,110,027
HIGGINS JOHN L Chief Executive Officer Feb 15, 2016 Option Exercise 214,237
FOEHR MATTHEW W President and COO Feb 15, 2016 Option Exercise 141,163
Herman Melanie J Director of Accounting Feb 15, 2016 Option Exercise 13,755
KOZARICH JOHN W Director Jan 20, 2016 Option Exercise 98,960
KOZARICH JOHN W Director Jan 20, 2016 Sale 158,173
Herman Melanie J Director of Accounting Dec 31, 2015 Option Exercise 11,554
Aryeh Jason Director Nov 11, 2015 Sale 304,470
Herman Melanie J Director of Accounting Nov 11, 2015 Option Exercise 365,034
Herman Melanie J Director of Accounting Nov 11, 2015 Sale 779,619
KNOTT DAVID M Director Aug 17, 2015 Sale 383,937
KNOTT DAVID M Director Aug 12, 2015 Sale 77,163
KNOTT DAVID M Director Aug 13, 2015 Sale 2,626,143
KNOTT DAVID M Director Aug 13, 2015 Sale 192,391
KNOTT DAVID M Director Aug 12, 2015 Sale 250,781
KNOTT DAVID M Director Aug 12, 2015 Sale 952,486
KNOTT DAVID M Director Aug 13, 2015 Sale 695,014
KNOTT DAVID M Director Aug 07, 2015 Sale 19,803
HIGGINS JOHN L Chief Executive Officer Aug 06, 2015 Sale 516,946
Davis Todd C Director Aug 06, 2015 Option Exercise 232,288
Berkman Charles S VP, Gen. Counsel & Secretary Jul 10, 2015 Option Exercise 178,687
Berkman Charles S VP, Gen. Counsel & Secretary Jul 13, 2015 Option Exercise 53,100
Berkman Charles S VP, Gen. Counsel & Secretary Jul 10, 2015 Sale 1,394,610
Berkman Charles S VP, Gen. Counsel & Secretary Jun 30, 2015 Option Exercise 21,237
Herman Melanie J Interim CFO Jun 30, 2015 Option Exercise 7,536
FOEHR MATTHEW W President and COO Jun 26, 2015 Option Exercise 124,625
FOEHR MATTHEW W President and COO Jun 29, 2015 Option Exercise 24,925
FOEHR MATTHEW W President and COO Jun 26, 2015 Sale 1,262,125
FOEHR MATTHEW W President and COO Jun 22, 2015 Option Exercise 249,709
FOEHR MATTHEW W President and COO Jun 22, 2015 Sale 2,222,815
Herman Melanie J Interim CFO Jun 10, 2015 Option Exercise 156,885
Herman Melanie J Interim CFO Jun 10, 2015 Sale 385,688
HIGGINS JOHN L Chief Executive Officer Jun 09, 2015 Sale 928,809
Aryeh Jason Director Jun 04, 2015 Sale 151,995
Aryeh Jason Director May 18, 2015 Sale 520,440
Aryeh Jason Director May 20, 2015 Sale 87,650
Aryeh Jason Director May 19, 2015 Sale 198,957
DeSilva Nishan M VP, Finance & Strategy and CFO May 13, 2015 Option Exercise 436,408
DeSilva Nishan M VP, Finance & Strategy and CFO May 12, 2015 Option Exercise 409,664
DeSilva Nishan M VP, Finance & Strategy and CFO May 14, 2015 Option Exercise 1,558,206
DeSilva Nishan M VP, Finance & Strategy and CFO May 12, 2015 Sale 1,990,403
DeSilva Nishan M VP, Finance & Strategy and CFO May 14, 2015 Sale 1,755,442
DeSilva Nishan M VP, Finance & Strategy and CFO May 13, 2015 Sale 1,990,671
Patel Sunil Director Mar 19, 2015 Sale 341,662
Berkman Charles S VP, Gen. Counsel & Secretary Mar 16, 2015 Option Exercise 106,939
Berkman Charles S VP, Gen. Counsel & Secretary Mar 16, 2015 Sale 839,649
Berkman Charles S VP, Gen. Counsel & Secretary Dec 31, 2014 Option Exercise 5,699
Herman Melanie J Director of Accounting Mar 02, 2015 Sale 32,469
Herman Melanie J Director of Accounting Dec 31, 2014 Option Exercise 4,659
Herman Melanie J Director of Accounting Feb 19, 2015 Sale 29,498
DeSilva Nishan M VP, Corporate Development Feb 10, 2015 Sale 129,582
Berkman Charles S VP, Gen. Counsel & Secretary Dec 31, 2014 Buy 5,699
FOEHR MATTHEW W EVP and COO Dec 31, 2014 Buy 2,081
Herman Melanie J Director of Accounting Dec 31, 2014 Buy 4,659
KOZARICH JOHN W Director Oct 15, 2014 Buy 91,360
FOEHR MATTHEW W EVP and COO Oct 13, 2014 Option Exercise 9,970
FOEHR MATTHEW W EVP and COO Oct 10, 2014 Buy 3,817
Sabba Stephen L Director Oct 09, 2014 Buy 86,230
KNOTT DAVID M Director Oct 09, 2014 Buy 172,029
Sabba Stephen L Director Oct 09, 2014 Option Exercise 86,230
KNOTT DAVID M Director Oct 09, 2014 Option Exercise 172,029
Aryeh Jason Director Oct 09, 2014 Buy 472,890
KOZARICH JOHN W Director Oct 07, 2014 Option Exercise 21,450
Aryeh Jason Director Oct 01, 2014 Option Exercise 236,920
Aryeh Jason Director Sep 25, 2014 Option Exercise 236,584
HIGGINS JOHN L President & CEO Aug 15, 2014 Buy 54,970
Herman Melanie J Director of Accounting Jun 30, 2014 Buy 4,292
Berkman Charles S VP, Gen. Counsel & Secretary Jun 30, 2014 Buy 14,408
FOEHR MATTHEW W EVP and COO Jun 30, 2014 Buy 18,743
Herman Melanie J Director of Accounting Jun 09, 2014 Option Exercise 13,741
Herman Melanie J Director of Accounting Jun 09, 2014 Sale 76,648
Berkman Charles S VP, Gen. Counsel & Secretary May 27, 2014 Option Exercise 47,007
Berkman Charles S VP, Gen. Counsel & Secretary May 27, 2014 Sale 479,434
BVF PARTNERS L P/IL See Explanation of Responses Mar 25, 2014 Sale 713,734
BVF PARTNERS L P/IL See Explanation of Responses Mar 25, 2014 Sale 1,260,489
BVF PARTNERS L P/IL See Explanation of Responses Mar 24, 2014 Sale 1,284,483
BVF PARTNERS L P/IL See Explanation of Responses Mar 24, 2014 Sale 2,224,163
Davis Todd C Director Mar 19, 2014 Sale 398,147
Davis Todd C Director Mar 18, 2014 Sale 198,637
LAMATTINA JOHN L Director Mar 18, 2014 Option Exercise 44,850
LAMATTINA JOHN L Director Mar 18, 2014 Sale 394,150
Sabba Stephen L Director Feb 27, 2014 Sale 36,125
KNOTT DAVID M Director Feb 20, 2014 Sale 65,676
BVF PARTNERS L P/IL 10% Owner Feb 18, 2014 Sale 1,045,409
BVF PARTNERS L P/IL 10% Owner Feb 19, 2014 Sale 202,375
BVF PARTNERS L P/IL 10% Owner Feb 20, 2014 Sale 391,464
BVF PARTNERS L P/IL 10% Owner Feb 18, 2014 Sale 11,478,450
BVF PARTNERS L P/IL 10% Owner Feb 19, 2014 Sale 4,189,921
BVF PARTNERS L P/IL 10% Owner Feb 20, 2014 Sale 8,208,319
BVF PARTNERS L P/IL 10% Owner Feb 18, 2014 Sale 1,219,209
BVF PARTNERS L P/IL 10% Owner Feb 19, 2014 Sale 394,015
BVF PARTNERS L P/IL 10% Owner Feb 20, 2014 Sale 771,167
BVF PARTNERS L P/IL 10% Owner Feb 18, 2014 Sale 1,262,808
BVF PARTNERS L P/IL 10% Owner Feb 19, 2014 Sale 691,187
BVF PARTNERS L P/IL 10% Owner Feb 20, 2014 Sale 1,359,787
KNOTT DAVID M Director Feb 18, 2014 Sale 285,919
KNOTT DAVID M Director Feb 18, 2014 Sale 845,368
KNOTT DAVID M Director Feb 14, 2014 Sale 516,583
KNOTT DAVID M Director Feb 14, 2014 Sale 1,524,229
Aryeh Jason Director Feb 14, 2014 Sale 749,265
Aryeh Jason Director Feb 13, 2014 Sale 518,779
Aryeh Jason Director Feb 12, 2014 Sale 1,814,121
Sharp John P VP Finance and CFO Feb 12, 2014 Option Exercise 1,528,059
Sharp John P VP Finance and CFO Feb 12, 2014 Sale 6,498,898
Berkman Charles S VP, Gen. Counsel & Secretary Feb 13, 2014 Option Exercise 28,940
Berkman Charles S VP, Gen. Counsel & Secretary Feb 12, 2014 Option Exercise 240,784
Berkman Charles S VP, Gen. Counsel & Secretary Feb 12, 2014 Sale 1,108,635
HIGGINS JOHN L President & CEO Feb 12, 2014 Option Exercise 168,075
HIGGINS JOHN L President & CEO Feb 12, 2014 Sale 1,265,625
FOEHR MATTHEW W EVP and COO Feb 14, 2014 Option Exercise 258,662
FOEHR MATTHEW W EVP and COO Feb 14, 2014 Sale 1,789,650
HIGGINS JOHN L President & CEO Jan 21, 2014 Option Exercise 189,000
HIGGINS JOHN L President & CEO Jan 16, 2014 Sale 960,000
FOEHR MATTHEW W EVP and COO Dec 31, 2013 Buy 2,849
Berkman Charles S VP, Gen. Counsel & Secretary Dec 31, 2013 Buy 7,088
Sharp John P VP Finance and CFO Dec 12, 2013 Option Exercise 6,972
Sharp John P VP Finance and CFO Dec 12, 2013 Sale 37,408
FOEHR MATTHEW W EVP and COO Dec 12, 2013 Option Exercise 59,820
FOEHR MATTHEW W EVP and COO Dec 12, 2013 Sale 320,400
Sharp John P VP Finance and CFO Dec 06, 2013 Sale 336,480
BVF PARTNERS L P/IL 10% Owner Nov 26, 2013 Sale 12,003,345
BVF PARTNERS L P/IL 10% Owner Nov 27, 2013 Sale 18,207,114
KOZARICH JOHN W Director Nov 25, 2013 Option Exercise 8,833
KOZARICH JOHN W Director Nov 18, 2013 Option Exercise 6,836
Sharp John P VP Finance and CFO Nov 18, 2013 Option Exercise 6,215
Sharp John P VP Finance and CFO Nov 18, 2013 Sale 59,519
HIGGINS JOHN L President & CEO Oct 22, 2013 Option Exercise 169,763
HIGGINS JOHN L President & CEO Oct 18, 2013 Sale 550,000
BVF PARTNERS L P/IL 10% Owner Sep 23, 2013 Sale 15,976,524
KNOTT DAVID M Director Sep 12, 2013 Sale 7,484,080
Berkman Charles S VP, Gen. Counsel & Secretary Aug 30, 2013 Option Exercise 653,697
Berkman Charles S VP, Gen. Counsel & Secretary Aug 30, 2013 Sale 1,346,456
Sharp John P VP Finance and CFO Aug 16, 2013 Option Exercise 74,700
Sharp John P VP Finance and CFO Aug 16, 2013 Sale 320,619
Berkman Charles S VP, Gen. Counsel & Secretary Aug 16, 2013 Option Exercise 145,247
Berkman Charles S VP, Gen. Counsel & Secretary Aug 19, 2013 Option Exercise 43,054
Berkman Charles S VP, Gen. Counsel & Secretary Aug 16, 2013 Sale 621,732
HIGGINS JOHN L President & CEO Aug 19, 2013 Option Exercise 105,814
HIGGINS JOHN L President & CEO Aug 16, 2013 Sale 428,500
DeSilva Nishan M VP, Corporate Development Jun 28, 2013 Buy 2,934
FOEHR MATTHEW W EVP and COO Jun 28, 2013 Buy 18,384
Berkman Charles S VP, Gen. Counsel & Secretary Jun 28, 2013 Buy 14,148
Berkman Charles S VP, Gen. Counsel & Secretary May 10, 2013 Sale 106,640
BVF PARTNERS L P/IL 10% Owner Jan 23, 2013 Buy 783,181
DeSilva Nishan M VP, Corporate Development Dec 31, 2012 Option Exercise 7,122
KOZARICH JOHN W Director Dec 21, 2012 Option Exercise 40,196
BVF PARTNERS L P/IL 10% Owner Dec 14, 2012 Buy 100,365
BVF PARTNERS L P/IL 10% Owner Dec 06, 2012 Buy 898,959
FOEHR MATTHEW W EVP and COO Dec 05, 2012 Buy 6,656
HIGGINS JOHN L President & CEO Dec 05, 2012 Buy 36,060
KNOTT DAVID M Director Nov 30, 2012 Sale 131,111
KNOTT DAVID M Director Nov 29, 2012 Sale 266,960
KNOTT DAVID M Director Nov 28, 2012 Sale 682,850
KNOTT DAVID M Director Nov 27, 2012 Sale 1,270,750
BVF PARTNERS L P/IL 10% Owner Oct 31, 2012 Buy 61,096
BVF PARTNERS L P/IL 10% Owner Oct 26, 2012 Buy 190,926
KNOTT DAVID M Director Aug 29, 2012 Buy 44,875
BVF PARTNERS L P/IL 10% Owner Oct 31, 2012 Buy 61,096
BVF PARTNERS L P/IL 10% Owner Oct 26, 2012 Buy 190,926
Berkman Charles S VP, Gen. Counsel & Secretary Sep 07, 2012 Sale 79,754
HIGGINS JOHN L President & CEO Aug 13, 2012 Buy 8,195
HIGGINS JOHN L President & CEO Jun 29, 2012 Option Exercise 12,654
FOEHR MATTHEW W EVP and COO Jun 29, 2012 Option Exercise 12,654
Berkman Charles S VP, Gen. Counsel & Secretary Jun 29, 2012 Option Exercise 12,654
Aryeh Jason Director Jun 01, 2012 Buy 8,386
Sabba Stephen L Director Jun 01, 2012 Option Exercise 24,040
KNOTT DAVID M Director May 24, 2012 Buy 277,718
KNOTT DAVID M Director May 24, 2012 Buy 1,999,802
KNOTT DAVID M Director May 24, 2012 Sale 885,061
KNOTT DAVID M Director May 24, 2012 Sale 1,146,115
KNOTT DAVID M Director May 24, 2012 Sale 246,344
Patel Sunil Director May 23, 2012 Buy 17,070
HIGGINS JOHN L President & CEO May 04, 2012 Buy 12,040
Berkman Charles S VP, Gen. Counsel & Secretary Mar 08, 2012 Sale 56,832
HIGGINS JOHN L President & CEO Dec 30, 2011 Option Exercise 2,119
FOEHR MATTHEW W EVP and COO Dec 30, 2011 Option Exercise 12,612
Berkman Charles S VP, Gen. Counsel & Secretary Dec 30, 2011 Option Exercise 12,491
BVF PARTNERS L P/IL 10% Owner Nov 18, 2011 Buy 799,795
BVF PARTNERS L P/IL 10% Owner Nov 21, 2011 Buy 3,602,718
BVF PARTNERS L P/IL 10% Owner Nov 21, 2011 Buy 1,039,631
KOZARICH JOHN W Director Nov 11, 2011 Buy 11,787
Sabba Stephen L Director Nov 10, 2011 Buy 11,690
Sabba Stephen L Director Nov 14, 2011 Buy 11,500
KNOTT DAVID M Director Nov 10, 2011 Buy 46,320
Aryeh Jason Director Nov 10, 2011 Buy 10,900
Aryeh Jason Director Nov 10, 2011 Buy 11,010
Patel Sunil Director Nov 10, 2011 Buy 27,774
BVF PARTNERS L P/IL 10% Owner Oct 26, 2011 Buy 83,751
BVF PARTNERS L P/IL 10% Owner Oct 21, 2011 Buy 64,062
BVF PARTNERS L P/IL 10% Owner Oct 20, 2011 Buy 165,809
BVF PARTNERS L P/IL 10% Owner Oct 18, 2011 Buy 30,215
BVF PARTNERS L P/IL 10% Owner Oct 13, 2011 Buy 233,880
BVF PARTNERS L P/IL 10% Owner Oct 13, 2011 Buy 67,692
BVF PARTNERS L P/IL 10% Owner Oct 12, 2011 Buy 726,992
BVF PARTNERS L P/IL 10% Owner Oct 04, 2011 Buy 183,961
KNOTT DAVID M Director Sep 01, 2011 Buy 37,721
KNOTT DAVID M Director Sep 01, 2011 Buy 10,647
KNOTT DAVID M Director Sep 01, 2011 Buy 22,815
KNOTT DAVID M Director Sep 01, 2011 Buy 80,917
KNOTT DAVID M Director Aug 31, 2011 Buy 8,964
KNOTT DAVID M Director Aug 30, 2011 Buy 24,321
KNOTT DAVID M Director Aug 31, 2011 Buy 2,988
KNOTT DAVID M Director Aug 30, 2011 Buy 10,381
KNOTT DAVID M Director Aug 31, 2011 Buy 7,470
KNOTT DAVID M Director Aug 30, 2011 Buy 20,762
KNOTT DAVID M Director Aug 31, 2011 Buy 25,398
KNOTT DAVID M Director Aug 30, 2011 Buy 77,116
KNOTT DAVID M Director Aug 26, 2011 Buy 139,934
KNOTT DAVID M Director Aug 29, 2011 Buy 75,313
KNOTT DAVID M Director Aug 26, 2011 Buy 32,604
KNOTT DAVID M Director Aug 29, 2011 Buy 17,052
KNOTT DAVID M Director Aug 26, 2011 Buy 82,764
KNOTT DAVID M Director Aug 29, 2011 Buy 44,051
KNOTT DAVID M Director Aug 26, 2011 Buy 265,848
KNOTT DAVID M Director Aug 29, 2011 Buy 147,784
KNOTT DAVID M Director Aug 25, 2011 Buy 246,372
KNOTT DAVID M Director Aug 25, 2011 Buy 216,204
KNOTT DAVID M Director Aug 25, 2011 Buy 124,443
KNOTT DAVID M Director Aug 25, 2011 Buy 31,425
KNOTT DAVID M Director Aug 25, 2011 Buy 72,906
KNOTT DAVID M Director Aug 23, 2011 Buy 14,616
KNOTT DAVID M Director Aug 24, 2011 Buy 11,655
KNOTT DAVID M Director Aug 23, 2011 Buy 37,758
KNOTT DAVID M Director Aug 24, 2011 Buy 30,950
KNOTT DAVID M Director Aug 24, 2011 Buy 33,670
KNOTT DAVID M Director Aug 23, 2011 Buy 125,454
KNOTT DAVID M Director Aug 24, 2011 Buy 97,125
KNOTT DAVID M Director Aug 24, 2011 Buy 53,095
KNOTT DAVID M Director Aug 23, 2011 Buy 65,772
KNOTT DAVID M Director Aug 24, 2011 Buy 51,800
KNOTT DAVID M Director Aug 19, 2011 Buy 21,528
KNOTT DAVID M Director Aug 22, 2011 Buy 2,400
KNOTT DAVID M Director Aug 22, 2011 Buy 6,000
KNOTT DAVID M Director Aug 19, 2011 Buy 51,428
KNOTT DAVID M Director Aug 22, 2011 Buy 20,400
KNOTT DAVID M Director Aug 19, 2011 Buy 171,028
KNOTT DAVID M Director Aug 19, 2011 Buy 88,504