| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| DENNER ALEXANDER J | Director | Mar 10, 2021 | Buy | $10.54 | 75,000 | 790,500 | 16,390,000 | Mar 10, 2021, 07:06 PM |
| DENNER ALEXANDER J | Director | Mar 08, 2021 | Buy | $10.30 | 150,000 | 1,545,000 | 16,315,000 | Mar 10, 2021, 07:06 PM |
| DENNER ALEXANDER J | Director | Mar 04, 2021 | Buy | $10.00 | 250,000 | 2,500,000 | 15,990,000 | Mar 05, 2021, 07:19 PM |
| DENNER ALEXANDER J | Director | Mar 03, 2021 | Buy | $10.02 | 350,000 | 3,507,000 | 15,740,000 | Mar 05, 2021, 07:19 PM |
| DENNER ALEXANDER J | Director | Mar 05, 2021 | Buy | $10.01 | 175,000 | 1,751,750 | 16,165,000 | Mar 05, 2021, 07:19 PM |
| DENNER ALEXANDER J | Director | Mar 02, 2021 | Buy | $9.56 | 500,000 | 4,780,000 | 15,390,000 | Mar 02, 2021, 08:18 PM |
| DENNER ALEXANDER J | Director | Mar 01, 2021 | Buy | $9.60 | 344,900 | 3,311,040 | 14,890,000 | Mar 02, 2021, 08:18 PM |
| DENNER ALEXANDER J | Director | Feb 26, 2021 | Buy | $9.20 | 505,100 | 4,646,920 | 14,545,100 | Mar 02, 2021, 08:18 PM |
| Shetzline Michael | CMO, SVP & Head of Drug Devt. | Feb 26, 2021 | Sale | $9.11 | 4,439 | 40,439 | 163,900 | Mar 02, 2021, 04:44 PM |
| Rickard Jason | SVP, Chief Operating Officer | Feb 26, 2021 | Sale | $9.11 | 13,651 | 124,361 | 317,665 | Mar 02, 2021, 04:43 PM |
| Owens Edward P | Director | Feb 26, 2021 | Buy | $8.90 | 3,000 | 26,700 | 218,954 | Mar 02, 2021, 04:41 PM |
| Kilroy Conor | SVP, GC & Secretary | Feb 26, 2021 | Sale | $9.11 | 6,989 | 63,670 | 127,926 | Mar 02, 2021, 04:36 PM |
| Consylman Gina | SVP, CFO & Treasurer | Feb 26, 2021 | Sale | $9.11 | 18,406 | 167,679 | 351,993 | Mar 02, 2021, 04:34 PM |
| MCCOURT Thomas A | President | Feb 26, 2021 | Sale | $9.11 | 14,685 | 133,780 | 483,680 | Mar 02, 2021, 12:00 AM |
| Mallon Mark | Chief Executive Officer | Feb 26, 2021 | Sale | $9.11 | 30,675 | 279,449 | 493,187 | Mar 02, 2021, 12:00 AM |
| Owens Edward P | Director | Feb 25, 2021 | Buy | $9.11 | 5,000 | 45,550 | 215,954 | Feb 26, 2021, 05:15 PM |
| Owens Edward P | Director | Feb 24, 2021 | Buy | $9.26 | 7,000 | 64,820 | 210,954 | Feb 26, 2021, 05:15 PM |
| MCCOURT Thomas A | President | Dec 14, 2020 | Option Exercise | $12.20 | 81,089 | 989,286 | 340,631 | Dec 16, 2020, 04:49 PM |
| MCCOURT Thomas A | President | Dec 14, 2020 | Option Exercise | $9.89 | 99,988 | 988,881 | 421,720 | Dec 16, 2020, 04:49 PM |
| MacDonald Kelly | Chief Accounting Officer | Dec 04, 2020 | Option Exercise | $9.12 | 5,639 | 51,428 | 98,680 | Dec 08, 2020, 04:01 PM |
| MacDonald Kelly | Chief Accounting Officer | Dec 04, 2020 | Sale | $12.50 | 5,639 | 70,488 | 93,041 | Dec 08, 2020, 04:01 PM |
| MacDonald Kelly | Chief Accounting Officer | Nov 11, 2020 | Option Exercise | $9.31 | 3,561 | 33,153 | 96,602 | Nov 13, 2020, 04:02 PM |
| MacDonald Kelly | Chief Accounting Officer | Nov 11, 2020 | Sale | $11.75 | 3,561 | 41,842 | 93,041 | Nov 13, 2020, 04:02 PM |
| Rickard Jason | SVP, Chief Operating Officer | Nov 09, 2020 | Sale | $10.92 | 394 | 4,302 | 235,382 | Nov 10, 2020, 04:12 PM |
| MacDonald Kelly | Chief Accounting Officer | Nov 09, 2020 | Sale | $10.92 | 925 | 10,101 | 93,141 | Nov 10, 2020, 04:10 PM |
| MacDonald Kelly | Chief Accounting Officer | Nov 06, 2020 | Sale | $11.25 | 1,872 | 21,060 | 93,966 | Nov 10, 2020, 04:10 PM |
| Kilroy Conor | SVP, GC & Secretary | Nov 09, 2020 | Sale | $10.92 | 836 | 9,129 | 129,070 | Nov 10, 2020, 04:09 PM |
| Consylman Gina | SVP, CFO & Treasurer | Nov 09, 2020 | Sale | $10.92 | 1,415 | 15,452 | 270,289 | Nov 10, 2020, 04:03 PM |
| MacDonald Kelly | Chief Accounting Officer | Oct 08, 2020 | Sale | $10.50 | 22,714 | 238,497 | 95,838 | Oct 13, 2020, 04:03 PM |
| McHugh Julie | Director | Sep 08, 2020 | Sale | $9.77 | 7,950 | 77,672 | 123,107 | Sep 09, 2020, 06:26 PM |
| Rickard Jason | SVP, Chief Operating Officer | Aug 17, 2020 | Sale | $10.14 | 689 | 6,986 | 235,776 | Aug 19, 2020, 04:05 PM |
| MacDonald Kelly | Chief Accounting Officer | Aug 17, 2020 | Sale | $10.14 | 575 | 5,831 | 118,552 | Aug 19, 2020, 04:01 PM |
| OLANOFF LAWRENCE S | Director | Jun 10, 2020 | Sale | $10.06 | 11,350 | 114,181 | 68,629 | Jun 12, 2020, 04:32 PM |
| Rickard Jason | SVP, Chief Operating Officer | May 11, 2020 | Sale | $10.35 | 510 | 5,279 | 234,580 | May 13, 2020, 05:23 PM |
| MCCOURT Thomas A | President | May 11, 2020 | Sale | $10.35 | 1,697 | 17,564 | 319,847 | May 13, 2020, 05:22 PM |
| Mallon Mark | Chief Executive Officer | May 11, 2020 | Sale | $10.35 | 23,206 | 240,182 | 501,280 | May 13, 2020, 05:21 PM |
| MacDonald Kelly | Chief Accounting Officer | May 11, 2020 | Sale | $10.35 | 1,153 | 11,934 | 118,742 | May 13, 2020, 05:20 PM |
| Kilroy Conor | SVP, GC & Secretary | May 11, 2020 | Sale | $10.35 | 716 | 7,411 | 129,479 | May 13, 2020, 05:19 PM |
| Mallon Mark | Chief Executive Officer | Feb 24, 2020 | Sale | $11.25 | 1 | 11 | 303,425 | Feb 25, 2020, 04:45 PM |
| Mallon Mark | Chief Executive Officer | Feb 21, 2020 | Sale | $11.63 | 7,983 | 92,842 | 303,426 | Feb 25, 2020, 04:45 PM |
| MCCOURT Thomas A | President | Feb 21, 2020 | Sale | $11.63 | 4,177 | 48,579 | 222,927 | Feb 25, 2020, 04:37 PM |
| Gilbert Halley E | Chief Admin Officer & SVP | Feb 21, 2020 | Sale | $11.63 | 15,328 | 178,265 | 278,566 | Feb 25, 2020, 04:33 PM |
| Consylman Gina | SVP, CFO & Treasurer | Feb 21, 2020 | Sale | $11.63 | 12,501 | 145,387 | 213,778 | Feb 25, 2020, 04:31 PM |
| MacDonald Kelly | Chief Accounting Officer | Feb 21, 2020 | Sale | $11.63 | 3,900 | 45,357 | 86,725 | Feb 25, 2020, 12:00 AM |
| Gilbert Halley E | Chief Admin Officer & SVP | Jan 31, 2020 | Option Exercise | $10.02 | 60,000 | 601,200 | 341,319 | Feb 04, 2020, 12:00 AM |
| Gilbert Halley E | Chief Admin Officer & SVP | Jan 31, 2020 | Sale | $12.05 | 60,000 | 723,000 | 281,319 | Feb 04, 2020, 12:00 AM |
| MCCOURT Thomas A | President | Jan 24, 2020 | Option Exercise | $10.02 | 20,000 | 200,400 | 245,239 | Jan 28, 2020, 04:02 PM |
| MCCOURT Thomas A | President | Jan 24, 2020 | Sale | $12.71 | 20,000 | 254,200 | 225,239 | Jan 28, 2020, 04:02 PM |
| Currie Mark G | Director | Jan 23, 2020 | Option Exercise | $9.12 | 60,000 | 547,200 | 609,272 | Jan 24, 2020, 04:43 PM |
| Currie Mark G | Director | Jan 23, 2020 | Sale | $12.59 | 60,000 | 755,400 | 549,272 | Jan 24, 2020, 04:43 PM |
| Currie Mark G | Director | Jan 16, 2020 | Option Exercise | $10.02 | 8,888 | 89,058 | 558,160 | Jan 21, 2020, 05:23 PM |
| Currie Mark G | Director | Jan 16, 2020 | Sale | $12.80 | 8,888 | 113,766 | 549,272 | Jan 21, 2020, 05:23 PM |
| MacDonald Kelly | Chief Accounting Officer | Nov 08, 2019 | Sale | $11.00 | 987 | 10,857 | 78,444 | Nov 12, 2019, 06:26 PM |
| Consylman Gina | SVP, CFO & Treasurer | Nov 08, 2019 | Sale | $11.00 | 1,510 | 16,610 | 174,768 | Nov 12, 2019, 06:23 PM |
| MCCOURT Thomas A | President | Aug 30, 2019 | Option Exercise | $4.88 | 220,000 | 1,073,600 | 329,739 | Sep 04, 2019, 04:42 PM |
| MCCOURT Thomas A | President | Aug 30, 2019 | Sale | $9.24 | 220,000 | 2,032,800 | 109,739 | Sep 04, 2019, 04:42 PM |
| Consylman Gina | SVP, CFO & Treasurer | Aug 16, 2019 | Sale | $9.04 | 212 | 1,916 | 175,648 | Aug 20, 2019, 05:37 PM |
| Gilbert Halley E | Chief Admin Officer & SVP | Jul 26, 2019 | Option Exercise | $4.88 | 20,000 | 97,600 | 260,169 | Jul 30, 2019, 04:48 PM |
| Gilbert Halley E | Chief Admin Officer & SVP | Jul 26, 2019 | Sale | $10.00 | 20,000 | 200,000 | 240,169 | Jul 30, 2019, 04:48 PM |
| OLANOFF LAWRENCE S | Director | Jun 05, 2019 | Sale | $11.25 | 2,000 | 22,500 | 58,259 | Jun 07, 2019, 04:06 PM |
| McHugh Julie | Director | Jun 05, 2019 | Sale | $11.26 | 1,500 | 16,890 | 109,337 | Jun 07, 2019, 04:05 PM |
| MCCOURT Thomas A | President | May 10, 2019 | Sale | $10.53 | 4,055 | 42,699 | 107,239 | May 14, 2019, 04:13 PM |
| Gilbert Halley E | Chief Admin Officer & SVP | May 10, 2019 | Sale | $10.53 | 4,055 | 42,699 | 238,240 | May 14, 2019, 04:12 PM |
| Currie Mark G | Director | May 10, 2019 | Sale | $10.53 | 4,055 | 42,699 | 528,903 | May 14, 2019, 04:10 PM |
| Consylman Gina | SVP, CFO & Treasurer | May 10, 2019 | Sale | $10.53 | 4,055 | 42,699 | 175,860 | May 14, 2019, 04:08 PM |
| Currie Mark G | Chief Scientific Officer | Mar 08, 2019 | Sale | $13.15 | 49,500 | 650,925 | 528,480 | Mar 08, 2019, 05:51 PM |
| Currie Mark G | Chief Scientific Officer | Mar 07, 2019 | Sale | $13.29 | 225,500 | 2,996,895 | 577,980 | Mar 08, 2019, 05:51 PM |
| McHugh Julie | Director | Mar 05, 2019 | Sale | $14.38 | 1,500 | 21,570 | 88,131 | Mar 06, 2019, 04:07 PM |
| OLANOFF LAWRENCE S | Director | Mar 05, 2019 | Sale | $14.41 | 2,000 | 28,820 | 37,553 | Mar 06, 2019, 04:06 PM |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 21, 2019 | Sale | $14.32 | 41 | 587 | 83,340 | Feb 22, 2019, 04:53 PM |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 20, 2019 | Sale | $14.31 | 4,800 | 68,688 | 86,938 | Feb 22, 2019, 04:53 PM |
| Gilbert Halley E | Chief Legal Officer | Feb 21, 2019 | Sale | $14.32 | 85 | 1,217 | 225,197 | Feb 22, 2019, 04:51 PM |
| Gilbert Halley E | Chief Legal Officer | Feb 20, 2019 | Sale | $14.31 | 10,157 | 145,347 | 233,229 | Feb 22, 2019, 04:51 PM |
| Currie Mark G | Chief Scientific Officer | Feb 21, 2019 | Sale | $14.32 | 13 | 186 | 803,480 | Feb 22, 2019, 04:49 PM |
| Currie Mark G | Chief Scientific Officer | Feb 20, 2019 | Sale | $14.31 | 1,631 | 23,340 | 803,493 | Feb 22, 2019, 04:49 PM |
| Consylman Gina | Chief Financial Officer | Feb 21, 2019 | Sale | $14.32 | 46 | 659 | 163,228 | Feb 22, 2019, 04:47 PM |
| Consylman Gina | Chief Financial Officer | Feb 20, 2019 | Sale | $14.31 | 5,631 | 80,580 | 168,543 | Feb 22, 2019, 04:47 PM |
| Gilbert Halley E | Chief Legal Officer | Jan 30, 2019 | Option Exercise | $4.89 | 20,449 | 99,996 | 235,372 | Jan 31, 2019, 05:35 PM |
| Hecht Peter M | Chief Executive Officer | Jan 23, 2019 | Option Exercise | $4.89 | 30,000 | 146,700 | 4,726,917 | Jan 25, 2019, 06:24 PM |
| Hecht Peter M | Chief Executive Officer | Jan 25, 2019 | Option Exercise | $4.89 | 50,000 | 244,500 | 4,726,468 | Jan 25, 2019, 06:24 PM |
| Hecht Peter M | Chief Executive Officer | Jan 24, 2019 | Option Exercise | $4.89 | 30,000 | 146,700 | 4,726,917 | Jan 25, 2019, 06:24 PM |
| Hecht Peter M | Chief Executive Officer | Jan 24, 2019 | Sale | $12.70 | 30,000 | 381,000 | 4,696,917 | Jan 25, 2019, 06:24 PM |
| Hecht Peter M | Chief Executive Officer | Jan 23, 2019 | Sale | $12.66 | 30,000 | 379,800 | 4,696,917 | Jan 25, 2019, 06:24 PM |
| Hecht Peter M | Chief Executive Officer | Jan 25, 2019 | Sale | $12.23 | 29,551 | 361,409 | 4,696,917 | Jan 25, 2019, 06:24 PM |
| McHugh Julie | Director | Dec 06, 2018 | Sale | $12.46 | 1,500 | 18,690 | 89,631 | Dec 10, 2018, 04:56 PM |
| OLANOFF LAWRENCE S | Director | Dec 06, 2018 | Sale | $12.47 | 2,000 | 24,940 | 39,553 | Dec 10, 2018, 04:37 PM |
| Consylman Gina | Chief Financial Officer | Nov 09, 2018 | Sale | $11.81 | 1,358 | 16,038 | 96,361 | Nov 13, 2018, 09:41 PM |
| Currie Mark G | Chief Scientific Officer | Oct 05, 2018 | Option Exercise | $10.85 | 116,651 | 1,265,465 | 146,775 | Oct 09, 2018, 06:42 PM |
| Currie Mark G | Chief Scientific Officer | Oct 04, 2018 | Option Exercise | $10.85 | 116,650 | 1,265,454 | 146,774 | Oct 09, 2018, 06:42 PM |
| Currie Mark G | Chief Scientific Officer | Oct 05, 2018 | Sale | $17.53 | 116,651 | 2,044,892 | 30,124 | Oct 09, 2018, 06:42 PM |
| Currie Mark G | Chief Scientific Officer | Oct 04, 2018 | Sale | $18.09 | 116,650 | 2,110,678 | 52,318 | Oct 09, 2018, 06:42 PM |
| OLANOFF LAWRENCE S | Director | Sep 05, 2018 | Sale | $19.10 | 2,000 | 38,200 | 41,553 | Sep 07, 2018, 04:01 PM |
| McHugh Julie | Director | Sep 05, 2018 | Sale | $19.10 | 1,500 | 28,650 | 91,131 | Sep 07, 2018, 04:01 PM |
| Currie Mark G | Chief Scientific Officer | Aug 24, 2018 | Option Exercise | $4.95 | 65,000 | 321,783 | 840,000 | Aug 28, 2018, 04:03 PM |
| Currie Mark G | Chief Scientific Officer | Aug 24, 2018 | Sale | $18.39 | 65,000 | 1,195,350 | 775,000 | Aug 28, 2018, 04:03 PM |
| Currie Mark G | Chief Scientific Officer | Aug 23, 2018 | Option Exercise | $4.95 | 65,000 | 321,784 | 840,000 | Aug 24, 2018, 05:21 PM |
| Currie Mark G | Chief Scientific Officer | Aug 22, 2018 | Option Exercise | $4.95 | 65,000 | 321,784 | 840,000 | Aug 24, 2018, 05:21 PM |
| Currie Mark G | Chief Scientific Officer | Aug 23, 2018 | Sale | $18.39 | 65,000 | 1,195,350 | 775,000 | Aug 24, 2018, 05:21 PM |
| Currie Mark G | Chief Scientific Officer | Aug 22, 2018 | Sale | $18.51 | 65,000 | 1,203,150 | 775,000 | Aug 24, 2018, 05:21 PM |
| Consylman Gina | Chief Financial Officer | Aug 17, 2018 | Sale | $18.21 | 188 | 3,423 | 97,719 | Aug 21, 2018, 04:57 PM |
| MCCOURT Thomas A | Chief Commercial Officer | Jul 06, 2018 | Option Exercise | $5.48 | 30,000 | 164,400 | 30,000 | Jul 10, 2018, 05:18 PM |
| MCCOURT Thomas A | Chief Commercial Officer | Jul 06, 2018 | Sale | $20.00 | 30,000 | 600,000 | 0 | Jul 10, 2018, 05:18 PM |
| Gilbert Halley E | Chief Legal Officer | Jul 03, 2018 | Option Exercise | $4.89 | 29,551 | 144,504 | 29,551 | Jul 05, 2018, 04:12 PM |
| Gilbert Halley E | Chief Legal Officer | Jul 03, 2018 | Sale | $19.75 | 29,551 | 583,632 | 0 | Jul 05, 2018, 04:12 PM |
| OLANOFF LAWRENCE S | Director | Jun 05, 2018 | Sale | $17.62 | 2,000 | 35,240 | 43,553 | Jun 07, 2018, 04:26 PM |
| McHugh Julie | Director | Jun 05, 2018 | Sale | $17.62 | 1,500 | 26,430 | 92,631 | Jun 07, 2018, 04:23 PM |
| OLANOFF LAWRENCE S | Director | Mar 05, 2018 | Sale | $14.05 | 2,000 | 28,100 | 29,330 | Mar 06, 2018, 07:17 PM |
| McHugh Julie | Director | Mar 05, 2018 | Sale | $14.06 | 1,500 | 21,090 | 77,908 | Mar 06, 2018, 07:15 PM |
| Currie Mark G | Chief Scientific Officer | Feb 21, 2018 | Sale | $14.66 | 1,634 | 23,954 | 18,124 | Feb 22, 2018, 06:06 PM |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 21, 2018 | Sale | $14.66 | 3,343 | 49,008 | 54,555 | Feb 22, 2018, 06:05 PM |
| Gilbert Halley E | Chief Legal Officer | Feb 21, 2018 | Sale | $14.66 | 7,741 | 113,483 | 99,602 | Feb 22, 2018, 06:04 PM |
| Consylman Gina | Chief Financial Officer | Feb 21, 2018 | Sale | $14.66 | 3,594 | 52,688 | 59,125 | Feb 22, 2018, 06:02 PM |
| Currie Mark G | Chief Scientific Officer | Jan 24, 2018 | Option Exercise | $3.76 | 60,000 | 225,600 | 835,000 | Jan 26, 2018, 04:09 PM |
| Currie Mark G | Chief Scientific Officer | Jan 24, 2018 | Sale | $15.45 | 60,000 | 927,000 | 775,000 | Jan 26, 2018, 04:09 PM |
| Hecht Peter M | Chief Executive Officer | Dec 07, 2017 | Option Exercise | $3.76 | 57,405 | 215,843 | 4,754,322 | Dec 08, 2017, 05:00 PM |
| Hecht Peter M | Chief Executive Officer | Dec 06, 2017 | Option Exercise | $3.76 | 82,595 | 310,557 | 4,752,917 | Dec 08, 2017, 05:00 PM |
| Hecht Peter M | Chief Executive Officer | Dec 06, 2017 | Sale | $15.24 | 56,000 | 853,440 | 4,696,917 | Dec 08, 2017, 05:00 PM |
| Hecht Peter M | Chief Executive Officer | Dec 07, 2017 | Sale | $15.00 | 57,405 | 861,075 | 4,696,917 | Dec 08, 2017, 05:00 PM |
| OLANOFF LAWRENCE S | Director | Dec 04, 2017 | Sale | $16.46 | 2,000 | 32,921 | 33,230 | Dec 06, 2017, 04:14 PM |
| McHugh Julie | Director | Dec 04, 2017 | Sale | $16.45 | 1,500 | 24,675 | 79,408 | Dec 06, 2017, 04:12 PM |
| Consylman Gina | Interim CFO and CAO | Nov 10, 2017 | Sale | $15.20 | 864 | 13,133 | 52,001 | Nov 14, 2017, 04:10 PM |
| OLANOFF LAWRENCE S | Director | Sep 05, 2017 | Sale | $16.15 | 2,000 | 32,300 | 33,330 | Sep 07, 2017, 04:40 PM |
| McHugh Julie | Director | Sep 05, 2017 | Sale | $16.16 | 1,500 | 24,240 | 80,908 | Sep 07, 2017, 04:38 PM |
| Consylman Gina | Chief Accounting Officer | Aug 18, 2017 | Sale | $14.34 | 207 | 2,968 | 52,865 | Aug 22, 2017, 04:07 PM |
| Gilbert Halley E | Chief Legal Officer | Jun 22, 2017 | Option Exercise | $3.76 | 35,000 | 131,600 | 35,000 | Jun 26, 2017, 04:22 PM |
| Gilbert Halley E | Chief Legal Officer | Jun 22, 2017 | Sale | $19.75 | 35,000 | 691,250 | 0 | Jun 26, 2017, 04:22 PM |
| OLANOFF LAWRENCE S | Director | Jun 08, 2017 | Sale | $17.78 | 3,200 | 56,896 | 35,330 | Jun 12, 2017, 04:27 PM |
| MCCOURT Thomas A | Chief Commercial Officer | May 15, 2017 | Option Exercise | $5.48 | 30,000 | 164,400 | 30,000 | May 16, 2017, 06:22 PM |
| MCCOURT Thomas A | Chief Commercial Officer | May 15, 2017 | Sale | $18.20 | 30,000 | 546,000 | 0 | May 16, 2017, 06:22 PM |
| Currie Mark G | Chief Scientific Officer | Mar 14, 2017 | Option Exercise | $3.76 | 60,000 | 225,600 | 835,000 | Mar 16, 2017, 05:08 PM |
| Currie Mark G | Chief Scientific Officer | Mar 14, 2017 | Sale | $17.06 | 60,000 | 1,023,600 | 775,000 | Mar 16, 2017, 05:08 PM |
| OLANOFF LAWRENCE S | Director | Mar 03, 2017 | Sale | $17.19 | 3,200 | 55,008 | 22,905 | Mar 07, 2017, 05:32 PM |
| Currie Mark G | Chief Scientific Officer | Feb 22, 2017 | Sale | $16.94 | 1,800 | 30,492 | 21,258 | Feb 24, 2017, 04:38 PM |
| Graney Thomas | Chief Financial Officer | Feb 22, 2017 | Sale | $16.94 | 1,874 | 31,746 | 22,180 | Feb 24, 2017, 04:37 PM |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 22, 2017 | Sale | $16.94 | 1,520 | 25,749 | 28,050 | Feb 24, 2017, 04:36 PM |
| Gilbert Halley E | Chief Legal Officer | Feb 22, 2017 | Sale | $16.94 | 5,039 | 85,361 | 63,481 | Feb 24, 2017, 04:35 PM |
| Consylman Gina | Chief Accounting Officer | Feb 22, 2017 | Sale | $16.94 | 1,839 | 31,153 | 31,215 | Feb 24, 2017, 04:34 PM |
| Gilbert Halley E | Chief Legal Officer | Feb 14, 2017 | Option Exercise | $3.76 | 37,385 | 140,568 | 37,385 | Feb 15, 2017, 06:12 PM |
| Gilbert Halley E | Chief Legal Officer | Feb 14, 2017 | Sale | $16.75 | 37,385 | 626,199 | 0 | Feb 15, 2017, 06:12 PM |
| Currie Mark G | Chief Scientific Officer | Jan 18, 2017 | Option Exercise | $2.94 | 55,987 | 164,602 | 775,000 | Jan 20, 2017, 05:57 PM |
| Hecht Peter M | Chief Executive Officer | Jan 11, 2017 | Option Exercise | $2.94 | 32,993 | 96,999 | 4,703,315 | Jan 13, 2017, 04:37 PM |
| Hecht Peter M | Chief Executive Officer | Jan 12, 2017 | Option Exercise | $2.94 | 32,994 | 97,002 | 4,703,316 | Jan 13, 2017, 04:37 PM |
| Hecht Peter M | Chief Executive Officer | Jan 12, 2017 | Sale | $15.50 | 32,994 | 511,407 | 4,670,322 | Jan 13, 2017, 04:37 PM |
| Hecht Peter M | Chief Executive Officer | Jan 11, 2017 | Sale | $15.84 | 32,993 | 522,609 | 4,670,322 | Jan 13, 2017, 04:37 PM |
| Currie Mark G | Chief Scientific Officer | Jan 06, 2017 | Option Exercise | $2.94 | 34,013 | 99,998 | 719,013 | Jan 10, 2017, 05:31 PM |
| OLANOFF LAWRENCE S | Director | Dec 05, 2016 | Sale | $15.68 | 3,200 | 50,176 | 26,105 | Dec 07, 2016, 06:57 PM |
| Gilbert Halley E | Chief Legal Officer | Nov 11, 2016 | Option Exercise | $3.76 | 14,000 | 52,640 | 14,000 | Nov 15, 2016, 05:11 PM |
| Gilbert Halley E | Chief Legal Officer | Nov 11, 2016 | Sale | $16.75 | 14,000 | 234,500 | 0 | Nov 15, 2016, 05:11 PM |
| Currie Mark G | Chief Scientific Officer | Oct 31, 2016 | Option Exercise | $2.94 | 300,000 | 882,000 | 685,000 | Nov 01, 2016, 06:16 PM |
| OLANOFF LAWRENCE S | Director | Sep 06, 2016 | Sale | $13.72 | 3,200 | 43,904 | 29,305 | Sep 07, 2016, 07:06 PM |
| Consylman Gina | Chief Accounting Officer | Aug 19, 2016 | Sale | $13.54 | 207 | 2,803 | 21,123 | Aug 22, 2016, 05:14 PM |
| OLANOFF LAWRENCE S | Director | Jun 03, 2016 | Sale | $12.92 | 2,200 | 28,424 | 32,505 | Jun 06, 2016, 05:15 PM |
| Gilbert Halley E | Chief Legal Officer | May 25, 2016 | Option Exercise | $3.76 | 15,865 | 59,652 | 10,000 | May 27, 2016, 04:47 PM |
| Gilbert Halley E | Chief Legal Officer | May 25, 2016 | Sale | $12.19 | 20,275 | 247,152 | 64,537 | May 27, 2016, 04:47 PM |
| Hecht Peter M | Chief Executive Officer | Mar 11, 2016 | Option Exercise | $1.56 | 40,000 | 62,400 | 4,710,322 | Mar 11, 2016, 06:19 PM |
| Hecht Peter M | Chief Executive Officer | Mar 09, 2016 | Option Exercise | $1.56 | 220,790 | 344,432 | 4,710,322 | Mar 11, 2016, 06:19 PM |
| Hecht Peter M | Chief Executive Officer | Mar 10, 2016 | Option Exercise | $1.56 | 40,000 | 62,400 | 4,710,322 | Mar 11, 2016, 06:19 PM |
| Hecht Peter M | Chief Executive Officer | Mar 10, 2016 | Sale | $10.63 | 40,000 | 425,200 | 4,670,322 | Mar 11, 2016, 06:19 PM |
| Hecht Peter M | Chief Executive Officer | Mar 11, 2016 | Sale | $10.66 | 40,000 | 426,400 | 4,670,322 | Mar 11, 2016, 06:19 PM |
| Hecht Peter M | Chief Executive Officer | Mar 09, 2016 | Sale | $10.87 | 40,000 | 434,800 | 4,670,322 | Mar 11, 2016, 06:19 PM |
| Currie Mark G | Chief Scientific Officer | Mar 09, 2016 | Option Exercise | $1.56 | 160,898 | 251,001 | 524,102 | Mar 11, 2016, 06:19 PM |
| Currie Mark G | Chief Scientific Officer | Mar 09, 2016 | Sale | $10.86 | 150,000 | 1,629,000 | 374,102 | Mar 11, 2016, 06:19 PM |
| OLANOFF LAWRENCE S | Director | Mar 07, 2016 | Sale | $11.11 | 2,200 | 24,442 | 11,031 | Mar 09, 2016, 06:21 PM |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 24, 2016 | Sale | $8.50 | 1,600 | 13,600 | 27,312 | Feb 26, 2016, 05:35 PM |
| Graney Thomas | Chief Financial Officer | Feb 24, 2016 | Sale | $8.50 | 563 | 4,786 | 5,137 | Feb 26, 2016, 05:31 PM |
| Consylman Gina | Chief Accounting Officer | Feb 24, 2016 | Sale | $8.50 | 420 | 3,570 | 6,330 | Feb 26, 2016, 05:29 PM |
| Gilbert Halley E | Chief Legal Officer | Feb 24, 2016 | Sale | $8.50 | 2,778 | 23,613 | 36,447 | Feb 26, 2016, 05:28 PM |
| Currie Mark G | Chief Scientific Officer | Feb 24, 2016 | Option Exercise | $1.56 | 150,000 | 234,000 | 524,102 | Feb 26, 2016, 05:24 PM |
| Currie Mark G | Chief Scientific Officer | Feb 24, 2016 | Sale | $8.53 | 152,154 | 1,297,809 | 374,102 | Feb 26, 2016, 05:24 PM |
| Owens Edward P | Director | Feb 24, 2016 | Buy | $8.32 | 10,000 | 83,200 | 144,006 | Feb 26, 2016, 04:34 PM |
| Currie Mark G | Chief Scientific Officer | Jan 04, 2016 | Option Exercise | $1.56 | 64,102 | 99,999 | 374,102 | Jan 06, 2016, 06:28 PM |
| Hecht Peter M | Chief Executive Officer | Dec 11, 2015 | Option Exercise | $1.56 | 250,000 | 390,000 | 4,489,532 | Dec 15, 2015, 06:32 PM |
| Hecht Peter M | Chief Executive Officer | Dec 15, 2015 | Sale | $11.07 | 73,418 | 812,737 | 0 | Dec 15, 2015, 06:32 PM |
| OLANOFF LAWRENCE S | Director | Dec 07, 2015 | Sale | $11.77 | 2,200 | 25,894 | 13,231 | Dec 08, 2015, 05:19 PM |
| Hecht Peter M | Chief Executive Officer | Oct 28, 2015 | Option Exercise | $2.04 | 98,115 | 199,997 | 4,239,532 | Oct 29, 2015, 05:57 PM |
| OLANOFF LAWRENCE S | Director | Sep 04, 2015 | Sale | $10.97 | 3,725 | 40,863 | 15,431 | Sep 09, 2015, 04:07 PM |
| ROBERTS BRYAN E | Director | Jun 15, 2015 | Option Exercise | $12.06 | 145 | 1,749 | 31,951 | Jun 16, 2015, 05:55 PM |
| Fanucci Marsha | Director | Mar 18, 2015 | Sale | $15.68 | 31,339 | 491,396 | 19,778 | Mar 20, 2015, 04:35 PM |
| Hecht Peter M | Chief Executive Officer | Mar 17, 2015 | Option Exercise | $1.56 | 125,000 | 195,000 | 4,266,417 | Mar 18, 2015, 04:28 PM |
| Hecht Peter M | Chief Executive Officer | Mar 16, 2015 | Option Exercise | $1.56 | 75,000 | 117,000 | 4,216,417 | Mar 18, 2015, 04:28 PM |
| Hecht Peter M | Chief Executive Officer | Mar 16, 2015 | Sale | $15.60 | 75,000 | 1,170,000 | 4,141,417 | Mar 18, 2015, 04:28 PM |
| Hecht Peter M | Chief Executive Officer | Mar 17, 2015 | Sale | $15.63 | 125,000 | 1,953,154 | 4,254,514 | Mar 18, 2015, 04:28 PM |
| ROBERTS BRYAN E | Director | Mar 13, 2015 | Option Exercise | $15.07 | 165 | 2,487 | 15,250 | Mar 17, 2015, 03:55 PM |
| COOK JOSEPH C JR | Director | Mar 11, 2015 | Sale | $15.53 | 2,600 | 40,378 | 43,975 | Mar 13, 2015, 04:27 PM |
| COOK JOSEPH C JR | Director | Mar 12, 2015 | Sale | $15.54 | 3,283 | 51,018 | 304,080 | Mar 13, 2015, 04:27 PM |
| ROBERTS BRYAN E | Director | Mar 09, 2015 | Sale | $15.63 | 6,500 | 101,595 | 82,270 | Mar 11, 2015, 04:12 PM |
| ROBERTS BRYAN E | Director | Mar 09, 2015 | Sale | $15.62 | 148 | 2,312 | 105 | Mar 11, 2015, 04:12 PM |
| ROBERTS BRYAN E | Director | Mar 10, 2015 | Sale | $15.17 | 89,245 | 1,353,847 | 0 | Mar 11, 2015, 04:12 PM |
| ROBERTS BRYAN E | Director | Mar 10, 2015 | Sale | $15.07 | 105 | 1,582 | 0 | Mar 11, 2015, 04:12 PM |
| Hecht Peter M | Chief Executive Officer | Mar 02, 2015 | Option Exercise | $1.56 | 13,908 | 21,696 | 4,155,325 | Mar 03, 2015, 07:54 PM |
| Hecht Peter M | Chief Executive Officer | Feb 27, 2015 | Option Exercise | $0.60 | 210,000 | 126,000 | 4,184,751 | Mar 03, 2015, 07:54 PM |
| Hecht Peter M | Chief Executive Officer | Mar 03, 2015 | Option Exercise | $1.56 | 6,200 | 9,672 | 4,147,617 | Mar 03, 2015, 07:54 PM |
| Hecht Peter M | Chief Executive Officer | Feb 27, 2015 | Sale | $15.68 | 43,334 | 679,432 | 4,164,351 | Mar 03, 2015, 07:54 PM |
| Hecht Peter M | Chief Executive Officer | Mar 03, 2015 | Sale | $15.71 | 6,200 | 97,402 | 4,141,417 | Mar 03, 2015, 07:54 PM |
| Hecht Peter M | Chief Executive Officer | Mar 02, 2015 | Sale | $16.00 | 13,908 | 222,528 | 4,141,417 | Mar 03, 2015, 07:54 PM |
| COOK JOSEPH C JR | Director | Feb 20, 2015 | Sale | $15.63 | 2,600 | 40,638 | 46,575 | Feb 23, 2015, 05:09 PM |
| COOK JOSEPH C JR | Director | Feb 19, 2015 | Sale | $15.60 | 32,900 | 513,240 | 49,175 | Feb 23, 2015, 05:09 PM |
| Currie Mark G | Chief Scientific Officer | Feb 19, 2015 | Option Exercise | $0.60 | 25,000 | 15,000 | 335,000 | Feb 23, 2015, 04:49 PM |
| Currie Mark G | Chief Scientific Officer | Feb 19, 2015 | Sale | $15.67 | 25,000 | 391,750 | 310,000 | Feb 23, 2015, 04:49 PM |
| Higgins Michael J | Chief Operating Officer | Dec 23, 2014 | Option Exercise | $1.56 | 29,102 | 45,399 | 329,102 | Dec 24, 2014, 04:01 PM |
| Higgins Michael J | Chief Operating Officer | Dec 16, 2014 | Option Exercise | $2.94 | 15,987 | 47,002 | 315,987 | Dec 18, 2014, 04:18 PM |
| Higgins Michael J | Chief Operating Officer | Dec 16, 2014 | Sale | $14.01 | 15,987 | 223,978 | 300,000 | Dec 18, 2014, 04:18 PM |
| ROBERTS BRYAN E | Director | Dec 15, 2014 | Option Exercise | $13.70 | 182 | 2,493 | 15,401 | Dec 16, 2014, 04:16 PM |
| ROBERTS BRYAN E | Director | Dec 15, 2014 | Sale | $15.06 | 1,200 | 18,072 | 16,498 | Dec 16, 2014, 04:16 PM |
| ROBERTS BRYAN E | Director | Dec 12, 2014 | Sale | $15.21 | 18,592 | 282,784 | 17,698 | Dec 16, 2014, 04:16 PM |
| COOK JOSEPH C JR | Director | Dec 11, 2014 | Sale | $15.00 | 100 | 1,500 | 80,675 | Dec 12, 2014, 04:31 PM |
| Higgins Michael J | Chief Operating Officer | Nov 24, 2014 | Option Exercise | $1.56 | 70,898 | 110,601 | 370,898 | Nov 26, 2014, 04:55 PM |
| Higgins Michael J | Chief Operating Officer | Nov 24, 2014 | Sale | $13.75 | 70,898 | 974,848 | 300,000 | Nov 26, 2014, 04:55 PM |
| Currie Mark G | Chief Scientific Officer | Nov 13, 2014 | Option Exercise | $0.60 | 20,000 | 12,000 | 330,000 | Nov 17, 2014, 05:04 PM |
| Currie Mark G | Chief Scientific Officer | Nov 13, 2014 | Sale | $13.63 | 20,000 | 272,600 | 310,000 | Nov 17, 2014, 05:04 PM |
| ROBERTS BRYAN E | Director | Sep 15, 2014 | Option Exercise | $12.59 | 198 | 2,493 | 15,219 | Sep 17, 2014, 02:38 PM |
| COOK JOSEPH C JR | Director | Jun 16, 2014 | Sale | $15.00 | 600 | 9,000 | 69,756 | Jun 18, 2014, 05:53 PM |
| ROBERTS BRYAN E | Director | Jun 13, 2014 | Option Exercise | $14.66 | 170 | 2,492 | 44,503 | Jun 16, 2014, 04:54 PM |
| ROBERTS BRYAN E | Director | Jun 12, 2014 | Sale | $14.24 | 200,000 | 2,848,000 | 0 | Jun 16, 2014, 04:54 PM |
| ROBERTS BRYAN E | Director | Jun 09, 2014 | Sale | $14.52 | 288,846 | 4,194,044 | 168,086 | Jun 11, 2014, 04:01 PM |
| ROBERTS BRYAN E | Director | May 30, 2014 | Sale | $14.52 | 411,154 | 5,969,956 | 410,839 | Jun 03, 2014, 05:13 PM |
| Higgins Michael J | Chief Operating Officer | May 29, 2014 | Sale | $14.56 | 50,000 | 728,000 | 0 | May 30, 2014, 05:07 PM |
| Currie Mark G | Chief Scientific Officer | May 22, 2014 | Option Exercise | $0.60 | 25,000 | 15,000 | 335,000 | May 23, 2014, 04:05 PM |
| Currie Mark G | Chief Scientific Officer | May 22, 2014 | Sale | $13.93 | 25,000 | 348,250 | 310,000 | May 23, 2014, 04:05 PM |
| Currie Mark G | Chief Scientific Officer | Apr 24, 2014 | Option Exercise | $0.60 | 25,000 | 15,000 | 335,000 | Apr 28, 2014, 04:24 PM |
| Currie Mark G | Chief Scientific Officer | Apr 24, 2014 | Sale | $11.67 | 25,000 | 291,750 | 310,000 | Apr 28, 2014, 04:24 PM |
| ROBERTS BRYAN E | Director | Mar 14, 2014 | Option Exercise | $12.76 | 195 | 2,488 | 24,555 | Mar 18, 2014, 04:44 PM |
| Hecht Peter M | Chief Executive Officer | Feb 20, 2014 | Option Exercise | $0.60 | 225,000 | 135,000 | 3,974,751 | Feb 24, 2014, 04:36 PM |
| Currie Mark G | Chief Scientific Officer | Feb 18, 2014 | Option Exercise | $0.60 | 15,000 | 9,000 | 325,000 | Feb 20, 2014, 06:43 PM |
| Currie Mark G | Chief Scientific Officer | Feb 18, 2014 | Sale | $14.43 | 15,000 | 216,450 | 310,000 | Feb 20, 2014, 06:43 PM |
| Currie Mark G | Chief Scientific Officer | Jan 23, 2014 | Option Exercise | $0.60 | 20,000 | 12,000 | 330,000 | Jan 24, 2014, 05:21 PM |
| Currie Mark G | Chief Scientific Officer | Jan 23, 2014 | Sale | $14.38 | 20,000 | 287,600 | 310,000 | Jan 24, 2014, 05:21 PM |
| ROBERTS BRYAN E | Director | Jan 14, 2014 | Sale | $12.57 | 21,200 | 266,484 | 756,383 | Jan 16, 2014, 04:19 PM |
| ROBERTS BRYAN E | Director | Jan 09, 2014 | Sale | $12.40 | 268,907 | 3,334,447 | 1,240,167 | Jan 13, 2014, 05:26 PM |
| ROBERTS BRYAN E | Director | Jan 13, 2014 | Sale | $12.57 | 254,443 | 3,198,348 | 774,200 | Jan 13, 2014, 05:26 PM |
| ROBERTS BRYAN E | Director | Jan 10, 2014 | Sale | $13.12 | 300,000 | 3,936,000 | 988,040 | Jan 13, 2014, 05:26 PM |
| ROBERTS BRYAN E | Director | Jan 06, 2014 | Sale | $12.06 | 1,600 | 19,296 | 1,466,163 | Jan 07, 2014, 04:53 PM |
| ROBERTS BRYAN E | Director | Jan 03, 2014 | Sale | $12.01 | 53,850 | 646,739 | 1,467,508 | Jan 07, 2014, 04:53 PM |
| ROBERTS BRYAN E | Director | Dec 31, 2013 | Option Exercise | $11.61 | 215 | 2,496 | 15,236 | Jan 03, 2014, 06:01 PM |
| MCGUIRE TERRANCE | Director | Nov 07, 2013 | Sale | $9.11 | 2,026 | 18,457 | 0 | Nov 08, 2013, 04:25 PM |
| MCGUIRE TERRANCE | Director | Nov 07, 2013 | Sale | $9.11 | 57 | 519 | 0 | Nov 08, 2013, 04:25 PM |
| ROBERTS BRYAN E | Director | Sep 30, 2013 | Option Exercise | $11.84 | 211 | 2,498 | 15,232 | Oct 02, 2013, 04:13 PM |
| Hecht Peter M | Chief Executive Officer | Jul 08, 2013 | Option Exercise | $0.60 | 100,000 | 60,000 | 3,749,751 | Jul 08, 2013, 06:23 PM |
| ROBERTS BRYAN E | Director | Jun 28, 2013 | Option Exercise | $9.93 | 251 | 2,492 | 15,272 | Jul 02, 2013, 05:09 PM |
| Higgins Michael J | Chief Operating Officer | Jun 14, 2013 | Option Exercise | $0.60 | 144,100 | 86,460 | 385,766 | Jun 18, 2013, 04:30 PM |
| Higgins Michael J | Chief Operating Officer | Jun 17, 2013 | Option Exercise | $0.60 | 114,234 | 68,540 | 300,000 | Jun 18, 2013, 04:30 PM |
| Higgins Michael J | Chief Operating Officer | Jun 17, 2013 | Sale | $11.84 | 5,900 | 69,856 | 266,666 | Jun 18, 2013, 04:30 PM |
| Higgins Michael J | Chief Operating Officer | Jun 14, 2013 | Sale | $11.74 | 144,100 | 1,691,734 | 241,666 | Jun 18, 2013, 04:30 PM |
| FMR LLC | 10% Owner | Mar 28, 2013 | Sale | $18.40 | 158,068 | 2,908,530 | 837,736 | Apr 02, 2013, 04:39 PM |
| ROBERTS BRYAN E | Director | Mar 28, 2013 | Option Exercise | $18.29 | 136 | 2,487 | 15,157 | Apr 01, 2013, 07:09 PM |
| MCCOURT Thomas A | Chief Commercial Officer | Mar 11, 2013 | Option Exercise | $5.48 | 40,000 | 219,200 | 40,000 | Mar 13, 2013, 05:04 PM |
| MCCOURT Thomas A | Chief Commercial Officer | Mar 11, 2013 | Sale | $17.00 | 40,000 | 680,000 | 0 | Mar 13, 2013, 05:04 PM |
| Higgins Michael J | Chief Operating Officer | Mar 06, 2013 | Option Exercise | $0.60 | 100,000 | 60,000 | 241,666 | Mar 07, 2013, 04:58 PM |
| Higgins Michael J | Chief Operating Officer | Mar 05, 2013 | Sale | $15.57 | 50,000 | 778,500 | 141,666 | Mar 07, 2013, 04:58 PM |
| Currie Mark G | Chief Scientific Officer | Feb 20, 2013 | Option Exercise | $0.60 | 100,000 | 60,000 | 310,000 | Feb 21, 2013, 05:40 PM |
| ROBERTS BRYAN E | Director | Dec 31, 2012 | Option Exercise | $11.08 | 225 | 2,493 | 15,788 | Jan 03, 2013, 01:23 PM |
| COOK JOSEPH C JR | Director | Nov 19, 2012 | Option Exercise | $0.60 | 40,000 | 24,000 | 101,909 | Nov 21, 2012, 04:21 PM |
| WALSH CHRISTOPHER T PHD | Director | Nov 07, 2012 | Option Exercise | $2.03 | 85,000 | 172,400 | 358,026 | Nov 08, 2012, 05:44 PM |
| Hecht Peter M | Chief Executive Officer | Nov 05, 2012 | Buy | $11.65 | 50,000 | 582,500 | 72,803 | Nov 06, 2012, 04:02 PM |
| FMR LLC | 10% Owner | Oct 12, 2012 | Sale | $13.37 | 118,220 | 1,580,743 | 1,271,057 | Oct 15, 2012, 04:33 PM |
| FMR LLC | 10% Owner | Oct 11, 2012 | Sale | $13.08 | 59,502 | 778,310 | 1,389,277 | Oct 15, 2012, 04:33 PM |
| FMR LLC | 10% Owner | Oct 15, 2012 | Sale | $13.13 | 35,153 | 461,541 | 1,235,904 | Oct 15, 2012, 04:33 PM |
| FMR LLC | 10% Owner | Oct 04, 2012 | Sale | $13.00 | 700 | 9,100 | 1,467,384 | Oct 09, 2012, 04:25 PM |
| FMR LLC | 10% Owner | Oct 08, 2012 | Sale | $13.00 | 5,878 | 76,432 | 1,448,779 | Oct 09, 2012, 04:25 PM |
| FMR LLC | 10% Owner | Oct 05, 2012 | Sale | $13.02 | 12,727 | 165,746 | 1,454,657 | Oct 09, 2012, 04:25 PM |
| FMR LLC | 10% Owner | Oct 03, 2012 | Sale | $13.00 | 6,300 | 81,900 | 1,468,084 | Oct 03, 2012, 04:30 PM |
| FMR LLC | 10% Owner | Oct 01, 2012 | Sale | $13.02 | 2,100 | 27,333 | 1,474,384 | Oct 03, 2012, 04:30 PM |
| ROBERTS BRYAN E | Director | Sep 28, 2012 | Option Exercise | $12.78 | 195 | 2,492 | 15,563 | Oct 02, 2012, 06:04 PM |
| FMR LLC | 10% Owner | Sep 27, 2012 | Sale | $13.24 | 43,622 | 577,342 | 1,476,484 | Sep 28, 2012, 04:04 PM |
| FMR LLC | 10% Owner | Sep 26, 2012 | Sale | $13.20 | 51,073 | 674,363 | 1,520,106 | Sep 28, 2012, 04:04 PM |
| FMR LLC | 10% Owner | Sep 25, 2012 | Sale | $13.88 | 36,056 | 500,634 | 1,571,179 | Sep 25, 2012, 04:46 PM |
| FMR LLC | 10% Owner | Sep 24, 2012 | Sale | $14.09 | 80,409 | 1,133,011 | 1,607,235 | Sep 25, 2012, 04:46 PM |
| FMR LLC | 10% Owner | Sep 21, 2012 | Sale | $14.89 | 119,221 | 1,775,070 | 1,806,865 | Sep 25, 2012, 04:46 PM |
| FMR LLC | 10% Owner | Sep 19, 2012 | Sale | $13.34 | 55,878 | 745,379 | 1,860,207 | Sep 20, 2012, 04:37 PM |
| FMR LLC | 10% Owner | Sep 18, 2012 | Sale | $13.53 | 49,113 | 664,317 | 1,916,085 | Sep 20, 2012, 04:37 PM |
| FMR LLC | 10% Owner | Sep 20, 2012 | Sale | $13.75 | 53,342 | 733,613 | 1,806,865 | Sep 20, 2012, 04:37 PM |
| FMR LLC | 10% Owner | Sep 13, 2012 | Sale | $13.06 | 29,514 | 385,491 | 2,089,460 | Sep 17, 2012, 04:25 PM |
| FMR LLC | 10% Owner | Sep 17, 2012 | Sale | $13.22 | 39,337 | 519,909 | 1,965,198 | Sep 17, 2012, 04:25 PM |
| FMR LLC | 10% Owner | Sep 14, 2012 | Sale | $13.14 | 84,925 | 1,115,719 | 2,004,535 | Sep 17, 2012, 04:25 PM |
| FMR LLC | 10% Owner | Aug 30, 2012 | Sale | $13.16 | 24,100 | 317,120 | 2,118,974 | Sep 04, 2012, 04:11 PM |
| FMR LLC | 10% Owner | Jul 31, 2012 | Sale | $13.09 | 5,345 | 69,971 | 2,143,074 | Aug 01, 2012, 04:42 PM |
| FMR LLC | 10% Owner | Jul 30, 2012 | Sale | $13.26 | 2,100 | 27,839 | 2,148,419 | Aug 01, 2012, 04:42 PM |
| FMR LLC | 10% Owner | Jul 27, 2012 | Sale | $13.38 | 41,419 | 554,012 | 2,150,519 | Jul 30, 2012, 08:50 AM |
| FMR LLC | 10% Owner | Jul 26, 2012 | Sale | $13.07 | 17,261 | 225,624 | 2,191,938 | Jul 30, 2012, 08:50 AM |
| FMR LLC | 10% Owner | Jul 25, 2012 | Sale | $13.00 | 200 | 2,600 | 2,209,199 | Jul 30, 2012, 08:50 AM |
| FMR LLC | 10% Owner | Jul 20, 2012 | Sale | $13.08 | 16,040 | 209,882 | 2,216,299 | Jul 24, 2012, 04:46 PM |
| FMR LLC | 10% Owner | Jul 24, 2012 | Sale | $13.01 | 6,900 | 89,743 | 2,209,399 | Jul 24, 2012, 04:46 PM |
| FMR LLC | 10% Owner | Jul 19, 2012 | Sale | $13.35 | 47,252 | 630,828 | 2,232,363 | Jul 20, 2012, 09:24 AM |
| FMR LLC | 10% Owner | Jul 18, 2012 | Sale | $13.40 | 18,060 | 242,029 | 2,279,615 | Jul 20, 2012, 09:24 AM |
| FMR LLC | 10% Owner | Jul 17, 2012 | Sale | $13.63 | 7,903 | 107,716 | 2,297,675 | Jul 20, 2012, 09:24 AM |
| FMR LLC | 10% Owner | Jul 16, 2012 | Sale | $13.80 | 14,708 | 202,956 | 2,305,578 | Jul 16, 2012, 05:10 PM |
| FMR LLC | 10% Owner | Jul 13, 2012 | Sale | $13.78 | 20,005 | 275,673 | 2,320,286 | Jul 16, 2012, 05:10 PM |
| FMR LLC | 10% Owner | Jul 12, 2012 | Sale | $13.33 | 600 | 7,999 | 2,340,291 | Jul 16, 2012, 05:10 PM |
| FMR LLC | 10% Owner | Jul 09, 2012 | Sale | $13.77 | 14,055 | 193,497 | 2,345,791 | Jul 11, 2012, 04:42 PM |
| FMR LLC | 10% Owner | Jul 10, 2012 | Sale | $13.86 | 4,900 | 67,934 | 2,340,891 | Jul 11, 2012, 04:42 PM |
| FMR LLC | 10% Owner | Jul 06, 2012 | Sale | $13.90 | 18,065 | 251,125 | 2,359,846 | Jul 06, 2012, 04:40 PM |
| FMR LLC | 10% Owner | Jul 05, 2012 | Sale | $14.00 | 16,960 | 237,423 | 2,377,911 | Jul 06, 2012, 04:40 PM |
| FMR LLC | 10% Owner | Jul 03, 2012 | Sale | $13.96 | 9,392 | 131,107 | 2,394,871 | Jul 06, 2012, 04:40 PM |
| FMR LLC | 10% Owner | Jul 02, 2012 | Sale | $13.92 | 14,700 | 204,624 | 2,404,263 | Jul 02, 2012, 05:23 PM |
| FMR LLC | 10% Owner | Jun 29, 2012 | Sale | $13.77 | 36,600 | 503,982 | 2,418,963 | Jul 02, 2012, 05:23 PM |
| FMR LLC | 10% Owner | Jun 28, 2012 | Sale | $13.94 | 5,274 | 73,520 | 2,455,563 | Jul 02, 2012, 05:23 PM |
| ROBERTS BRYAN E | Director | Jun 29, 2012 | Option Exercise | $13.78 | 181 | 2,494 | 15,368 | Jul 02, 2012, 04:33 PM |
| Hecht Peter M | Chief Executive Officer | Apr 05, 2012 | Option Exercise | $0.41 | 150,000 | 61,500 | 3,649,751 | Apr 09, 2012, 04:16 PM |
| ROBERTS BRYAN E | Director | Mar 30, 2012 | Option Exercise | $13.31 | 187 | 2,489 | 187 | Apr 03, 2012, 02:50 PM |
| Ridgeback Capital Investments L.P. | 10% Owner | Feb 06, 2012 | Sale | $14.80 | 47,229 | 698,989 | 6,842,839 | Feb 09, 2012, 09:56 PM |
| Ridgeback Capital Investments L.P. | 10% Owner | Feb 03, 2012 | Sale | $14.92 | 61,949 | 924,279 | 6,890,068 | Feb 09, 2012, 09:56 PM |
| Ridgeback Capital Investments L.P. | 10% Owner | Feb 02, 2012 | Sale | $15.03 | 3,300 | 49,599 | 6,952,017 | Feb 09, 2012, 09:56 PM |
| WALSH CHRISTOPHER T PHD | Director | Jan 13, 2012 | Option Exercise | $0.31 | 6,000 | 1,860 | 273,026 | Jan 18, 2012, 04:09 PM |
| Higgins Michael J | Chief Operating Officer | Sep 02, 2011 | Option Exercise | $0.60 | 66,666 | 40,000 | 191,666 | Sep 06, 2011, 05:20 PM |
| Higgins Michael J | Chief Operating Officer | Jun 24, 2011 | Sale | $15.94 | 25,000 | 398,500 | 125,000 | Jun 28, 2011, 04:08 PM |
| Ridgeback Capital Investments L.P. | 10% Owner | Jun 23, 2011 | Sale | $16.19 | 500,000 | 8,095,000 | 9,889,262 | Jun 27, 2011, 06:13 PM |
| Currie Mark G | Chief Scientific Officer | Apr 21, 2011 | Option Exercise | $0.60 | 20,000 | 12,000 | 230,000 | Apr 22, 2011, 01:59 PM |
| Currie Mark G | Chief Scientific Officer | Apr 21, 2011 | Sale | $15.17 | 20,000 | 303,400 | 210,000 | Apr 22, 2011, 01:59 PM |
| Currie Mark G | Chief Scientific Officer | Apr 14, 2011 | Option Exercise | $0.60 | 15,137 | 9,082 | 225,137 | Apr 15, 2011, 09:43 AM |
| Currie Mark G | Chief Scientific Officer | Apr 14, 2011 | Sale | $15.00 | 15,137 | 227,055 | 210,000 | Apr 15, 2011, 09:43 AM |
| Currie Mark G | Chief Scientific Officer | Apr 13, 2011 | Option Exercise | $0.60 | 24,263 | 14,558 | 234,263 | Apr 13, 2011, 05:12 PM |
| Currie Mark G | Chief Scientific Officer | Apr 11, 2011 | Option Exercise | $0.60 | 600 | 360 | 210,600 | Apr 13, 2011, 05:12 PM |
| Currie Mark G | Chief Scientific Officer | Apr 13, 2011 | Sale | $15.00 | 24,263 | 363,945 | 210,000 | Apr 13, 2011, 05:12 PM |
| Currie Mark G | Chief Scientific Officer | Apr 11, 2011 | Sale | $15.00 | 600 | 9,000 | 210,000 | Apr 13, 2011, 05:12 PM |
| Currie Mark G | Chief Scientific Officer | Mar 21, 2011 | Option Exercise | $0.60 | 40,000 | 24,000 | 250,000 | Mar 22, 2011, 04:18 PM |
| Currie Mark G | Chief Scientific Officer | Mar 21, 2011 | Sale | $13.21 | 40,000 | 528,400 | 210,000 | Mar 22, 2011, 04:18 PM |
| Currie Mark G | Chief Scientific Officer | Mar 03, 2011 | Option Exercise | $0.60 | 7,721 | 4,633 | 217,721 | Mar 04, 2011, 11:40 AM |
| Currie Mark G | Chief Scientific Officer | Mar 03, 2011 | Sale | $12.51 | 7,721 | 96,590 | 210,000 | Mar 04, 2011, 11:40 AM |
| Currie Mark G | Chief Scientific Officer | Feb 28, 2011 | Option Exercise | $0.60 | 1,900 | 1,140 | 211,900 | Mar 01, 2011, 03:06 PM |
| Currie Mark G | Chief Scientific Officer | Feb 25, 2011 | Option Exercise | $0.60 | 379 | 227 | 210,379 | Mar 01, 2011, 03:06 PM |
| Currie Mark G | Chief Scientific Officer | Feb 28, 2011 | Sale | $12.50 | 1,900 | 23,750 | 210,000 | Mar 01, 2011, 03:06 PM |
| Currie Mark G | Chief Scientific Officer | Feb 25, 2011 | Sale | $12.50 | 379 | 4,738 | 210,000 | Mar 01, 2011, 03:06 PM |
| Currie Mark G | Chief Scientific Officer | Feb 23, 2011 | Option Exercise | $0.60 | 5,214 | 3,128 | 215,214 | Feb 23, 2011, 09:16 PM |
| Currie Mark G | Chief Scientific Officer | Feb 22, 2011 | Option Exercise | $0.60 | 24,786 | 14,872 | 234,786 | Feb 23, 2011, 09:16 PM |
| Currie Mark G | Chief Scientific Officer | Feb 23, 2011 | Sale | $12.06 | 5,214 | 62,881 | 210,000 | Feb 23, 2011, 09:16 PM |
| Currie Mark G | Chief Scientific Officer | Feb 22, 2011 | Sale | $11.85 | 24,786 | 293,714 | 210,000 | Feb 23, 2011, 09:16 PM |
| WALSH CHRISTOPHER T PHD | Director | Feb 09, 2011 | Option Exercise | $0.31 | 6,000 | 1,860 | 267,026 | Feb 11, 2011, 02:04 PM |
| Owner | Relationship | Date | Transaction | Value($) |
| DENNER ALEXANDER J | Director | Mar 10, 2021 | Buy | 790,500 |
| DENNER ALEXANDER J | Director | Mar 08, 2021 | Buy | 1,545,000 |
| DENNER ALEXANDER J | Director | Mar 04, 2021 | Buy | 2,500,000 |
| DENNER ALEXANDER J | Director | Mar 03, 2021 | Buy | 3,507,000 |
| DENNER ALEXANDER J | Director | Mar 05, 2021 | Buy | 1,751,750 |
| DENNER ALEXANDER J | Director | Mar 02, 2021 | Buy | 4,780,000 |
| DENNER ALEXANDER J | Director | Mar 01, 2021 | Buy | 3,311,040 |
| DENNER ALEXANDER J | Director | Feb 26, 2021 | Buy | 4,646,920 |
| Shetzline Michael | CMO, SVP & Head of Drug Devt. | Feb 26, 2021 | Sale | 40,439 |
| Rickard Jason | SVP, Chief Operating Officer | Feb 26, 2021 | Sale | 124,361 |
| Owens Edward P | Director | Feb 26, 2021 | Buy | 26,700 |
| Kilroy Conor | SVP, GC & Secretary | Feb 26, 2021 | Sale | 63,670 |
| Consylman Gina | SVP, CFO & Treasurer | Feb 26, 2021 | Sale | 167,679 |
| MCCOURT Thomas A | President | Feb 26, 2021 | Sale | 133,780 |
| Mallon Mark | Chief Executive Officer | Feb 26, 2021 | Sale | 279,449 |
| Owens Edward P | Director | Feb 25, 2021 | Buy | 45,550 |
| Owens Edward P | Director | Feb 24, 2021 | Buy | 64,820 |
| MCCOURT Thomas A | President | Dec 14, 2020 | Option Exercise | 989,286 |
| MCCOURT Thomas A | President | Dec 14, 2020 | Option Exercise | 988,881 |
| MacDonald Kelly | Chief Accounting Officer | Dec 04, 2020 | Option Exercise | 51,428 |
| MacDonald Kelly | Chief Accounting Officer | Dec 04, 2020 | Sale | 70,488 |
| MacDonald Kelly | Chief Accounting Officer | Nov 11, 2020 | Option Exercise | 33,153 |
| MacDonald Kelly | Chief Accounting Officer | Nov 11, 2020 | Sale | 41,842 |
| Rickard Jason | SVP, Chief Operating Officer | Nov 09, 2020 | Sale | 4,302 |
| MacDonald Kelly | Chief Accounting Officer | Nov 09, 2020 | Sale | 10,101 |
| MacDonald Kelly | Chief Accounting Officer | Nov 06, 2020 | Sale | 21,060 |
| Kilroy Conor | SVP, GC & Secretary | Nov 09, 2020 | Sale | 9,129 |
| Consylman Gina | SVP, CFO & Treasurer | Nov 09, 2020 | Sale | 15,452 |
| MacDonald Kelly | Chief Accounting Officer | Oct 08, 2020 | Sale | 238,497 |
| McHugh Julie | Director | Sep 08, 2020 | Sale | 77,672 |
| Rickard Jason | SVP, Chief Operating Officer | Aug 17, 2020 | Sale | 6,986 |
| MacDonald Kelly | Chief Accounting Officer | Aug 17, 2020 | Sale | 5,831 |
| OLANOFF LAWRENCE S | Director | Jun 10, 2020 | Sale | 114,181 |
| Rickard Jason | SVP, Chief Operating Officer | May 11, 2020 | Sale | 5,279 |
| MCCOURT Thomas A | President | May 11, 2020 | Sale | 17,564 |
| Mallon Mark | Chief Executive Officer | May 11, 2020 | Sale | 240,182 |
| MacDonald Kelly | Chief Accounting Officer | May 11, 2020 | Sale | 11,934 |
| Kilroy Conor | SVP, GC & Secretary | May 11, 2020 | Sale | 7,411 |
| Mallon Mark | Chief Executive Officer | Feb 24, 2020 | Sale | 11 |
| Mallon Mark | Chief Executive Officer | Feb 21, 2020 | Sale | 92,842 |
| MCCOURT Thomas A | President | Feb 21, 2020 | Sale | 48,579 |
| Gilbert Halley E | Chief Admin Officer & SVP | Feb 21, 2020 | Sale | 178,265 |
| Consylman Gina | SVP, CFO & Treasurer | Feb 21, 2020 | Sale | 145,387 |
| MacDonald Kelly | Chief Accounting Officer | Feb 21, 2020 | Sale | 45,357 |
| Gilbert Halley E | Chief Admin Officer & SVP | Jan 31, 2020 | Option Exercise | 601,200 |
| Gilbert Halley E | Chief Admin Officer & SVP | Jan 31, 2020 | Sale | 723,000 |
| MCCOURT Thomas A | President | Jan 24, 2020 | Option Exercise | 200,400 |
| MCCOURT Thomas A | President | Jan 24, 2020 | Sale | 254,200 |
| Currie Mark G | Director | Jan 23, 2020 | Option Exercise | 547,200 |
| Currie Mark G | Director | Jan 23, 2020 | Sale | 755,400 |
| Currie Mark G | Director | Jan 16, 2020 | Option Exercise | 89,058 |
| Currie Mark G | Director | Jan 16, 2020 | Sale | 113,766 |
| MacDonald Kelly | Chief Accounting Officer | Nov 08, 2019 | Sale | 10,857 |
| Consylman Gina | SVP, CFO & Treasurer | Nov 08, 2019 | Sale | 16,610 |
| MCCOURT Thomas A | President | Aug 30, 2019 | Option Exercise | 1,073,600 |
| MCCOURT Thomas A | President | Aug 30, 2019 | Sale | 2,032,800 |
| Consylman Gina | SVP, CFO & Treasurer | Aug 16, 2019 | Sale | 1,916 |
| Gilbert Halley E | Chief Admin Officer & SVP | Jul 26, 2019 | Option Exercise | 97,600 |
| Gilbert Halley E | Chief Admin Officer & SVP | Jul 26, 2019 | Sale | 200,000 |
| OLANOFF LAWRENCE S | Director | Jun 05, 2019 | Sale | 22,500 |
| McHugh Julie | Director | Jun 05, 2019 | Sale | 16,890 |
| MCCOURT Thomas A | President | May 10, 2019 | Sale | 42,699 |
| Gilbert Halley E | Chief Admin Officer & SVP | May 10, 2019 | Sale | 42,699 |
| Currie Mark G | Director | May 10, 2019 | Sale | 42,699 |
| Consylman Gina | SVP, CFO & Treasurer | May 10, 2019 | Sale | 42,699 |
| Currie Mark G | Chief Scientific Officer | Mar 08, 2019 | Sale | 650,925 |
| Currie Mark G | Chief Scientific Officer | Mar 07, 2019 | Sale | 2,996,895 |
| McHugh Julie | Director | Mar 05, 2019 | Sale | 21,570 |
| OLANOFF LAWRENCE S | Director | Mar 05, 2019 | Sale | 28,820 |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 21, 2019 | Sale | 587 |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 20, 2019 | Sale | 68,688 |
| Gilbert Halley E | Chief Legal Officer | Feb 21, 2019 | Sale | 1,217 |
| Gilbert Halley E | Chief Legal Officer | Feb 20, 2019 | Sale | 145,347 |
| Currie Mark G | Chief Scientific Officer | Feb 21, 2019 | Sale | 186 |
| Currie Mark G | Chief Scientific Officer | Feb 20, 2019 | Sale | 23,340 |
| Consylman Gina | Chief Financial Officer | Feb 21, 2019 | Sale | 659 |
| Consylman Gina | Chief Financial Officer | Feb 20, 2019 | Sale | 80,580 |
| Gilbert Halley E | Chief Legal Officer | Jan 30, 2019 | Option Exercise | 99,996 |
| Hecht Peter M | Chief Executive Officer | Jan 23, 2019 | Option Exercise | 146,700 |
| Hecht Peter M | Chief Executive Officer | Jan 25, 2019 | Option Exercise | 244,500 |
| Hecht Peter M | Chief Executive Officer | Jan 24, 2019 | Option Exercise | 146,700 |
| Hecht Peter M | Chief Executive Officer | Jan 24, 2019 | Sale | 381,000 |
| Hecht Peter M | Chief Executive Officer | Jan 23, 2019 | Sale | 379,800 |
| Hecht Peter M | Chief Executive Officer | Jan 25, 2019 | Sale | 361,409 |
| McHugh Julie | Director | Dec 06, 2018 | Sale | 18,690 |
| OLANOFF LAWRENCE S | Director | Dec 06, 2018 | Sale | 24,940 |
| Consylman Gina | Chief Financial Officer | Nov 09, 2018 | Sale | 16,038 |
| Currie Mark G | Chief Scientific Officer | Oct 05, 2018 | Option Exercise | 1,265,465 |
| Currie Mark G | Chief Scientific Officer | Oct 04, 2018 | Option Exercise | 1,265,454 |
| Currie Mark G | Chief Scientific Officer | Oct 05, 2018 | Sale | 2,044,892 |
| Currie Mark G | Chief Scientific Officer | Oct 04, 2018 | Sale | 2,110,678 |
| OLANOFF LAWRENCE S | Director | Sep 05, 2018 | Sale | 38,200 |
| McHugh Julie | Director | Sep 05, 2018 | Sale | 28,650 |
| Currie Mark G | Chief Scientific Officer | Aug 24, 2018 | Option Exercise | 321,783 |
| Currie Mark G | Chief Scientific Officer | Aug 24, 2018 | Sale | 1,195,350 |
| Currie Mark G | Chief Scientific Officer | Aug 23, 2018 | Option Exercise | 321,784 |
| Currie Mark G | Chief Scientific Officer | Aug 22, 2018 | Option Exercise | 321,784 |
| Currie Mark G | Chief Scientific Officer | Aug 23, 2018 | Sale | 1,195,350 |
| Currie Mark G | Chief Scientific Officer | Aug 22, 2018 | Sale | 1,203,150 |
| Consylman Gina | Chief Financial Officer | Aug 17, 2018 | Sale | 3,423 |
| MCCOURT Thomas A | Chief Commercial Officer | Jul 06, 2018 | Option Exercise | 164,400 |
| MCCOURT Thomas A | Chief Commercial Officer | Jul 06, 2018 | Sale | 600,000 |
| Gilbert Halley E | Chief Legal Officer | Jul 03, 2018 | Option Exercise | 144,504 |
| Gilbert Halley E | Chief Legal Officer | Jul 03, 2018 | Sale | 583,632 |
| OLANOFF LAWRENCE S | Director | Jun 05, 2018 | Sale | 35,240 |
| McHugh Julie | Director | Jun 05, 2018 | Sale | 26,430 |
| OLANOFF LAWRENCE S | Director | Mar 05, 2018 | Sale | 28,100 |
| McHugh Julie | Director | Mar 05, 2018 | Sale | 21,090 |
| Currie Mark G | Chief Scientific Officer | Feb 21, 2018 | Sale | 23,954 |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 21, 2018 | Sale | 49,008 |
| Gilbert Halley E | Chief Legal Officer | Feb 21, 2018 | Sale | 113,483 |
| Consylman Gina | Chief Financial Officer | Feb 21, 2018 | Sale | 52,688 |
| Currie Mark G | Chief Scientific Officer | Jan 24, 2018 | Option Exercise | 225,600 |
| Currie Mark G | Chief Scientific Officer | Jan 24, 2018 | Sale | 927,000 |
| Hecht Peter M | Chief Executive Officer | Dec 07, 2017 | Option Exercise | 215,843 |
| Hecht Peter M | Chief Executive Officer | Dec 06, 2017 | Option Exercise | 310,557 |
| Hecht Peter M | Chief Executive Officer | Dec 06, 2017 | Sale | 853,440 |
| Hecht Peter M | Chief Executive Officer | Dec 07, 2017 | Sale | 861,075 |
| OLANOFF LAWRENCE S | Director | Dec 04, 2017 | Sale | 32,921 |
| McHugh Julie | Director | Dec 04, 2017 | Sale | 24,675 |
| Consylman Gina | Interim CFO and CAO | Nov 10, 2017 | Sale | 13,133 |
| OLANOFF LAWRENCE S | Director | Sep 05, 2017 | Sale | 32,300 |
| McHugh Julie | Director | Sep 05, 2017 | Sale | 24,240 |
| Consylman Gina | Chief Accounting Officer | Aug 18, 2017 | Sale | 2,968 |
| Gilbert Halley E | Chief Legal Officer | Jun 22, 2017 | Option Exercise | 131,600 |
| Gilbert Halley E | Chief Legal Officer | Jun 22, 2017 | Sale | 691,250 |
| OLANOFF LAWRENCE S | Director | Jun 08, 2017 | Sale | 56,896 |
| MCCOURT Thomas A | Chief Commercial Officer | May 15, 2017 | Option Exercise | 164,400 |
| MCCOURT Thomas A | Chief Commercial Officer | May 15, 2017 | Sale | 546,000 |
| Currie Mark G | Chief Scientific Officer | Mar 14, 2017 | Option Exercise | 225,600 |
| Currie Mark G | Chief Scientific Officer | Mar 14, 2017 | Sale | 1,023,600 |
| OLANOFF LAWRENCE S | Director | Mar 03, 2017 | Sale | 55,008 |
| Currie Mark G | Chief Scientific Officer | Feb 22, 2017 | Sale | 30,492 |
| Graney Thomas | Chief Financial Officer | Feb 22, 2017 | Sale | 31,746 |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 22, 2017 | Sale | 25,749 |
| Gilbert Halley E | Chief Legal Officer | Feb 22, 2017 | Sale | 85,361 |
| Consylman Gina | Chief Accounting Officer | Feb 22, 2017 | Sale | 31,153 |
| Gilbert Halley E | Chief Legal Officer | Feb 14, 2017 | Option Exercise | 140,568 |
| Gilbert Halley E | Chief Legal Officer | Feb 14, 2017 | Sale | 626,199 |
| Currie Mark G | Chief Scientific Officer | Jan 18, 2017 | Option Exercise | 164,602 |
| Hecht Peter M | Chief Executive Officer | Jan 11, 2017 | Option Exercise | 96,999 |
| Hecht Peter M | Chief Executive Officer | Jan 12, 2017 | Option Exercise | 97,002 |
| Hecht Peter M | Chief Executive Officer | Jan 12, 2017 | Sale | 511,407 |
| Hecht Peter M | Chief Executive Officer | Jan 11, 2017 | Sale | 522,609 |
| Currie Mark G | Chief Scientific Officer | Jan 06, 2017 | Option Exercise | 99,998 |
| OLANOFF LAWRENCE S | Director | Dec 05, 2016 | Sale | 50,176 |
| Gilbert Halley E | Chief Legal Officer | Nov 11, 2016 | Option Exercise | 52,640 |
| Gilbert Halley E | Chief Legal Officer | Nov 11, 2016 | Sale | 234,500 |
| Currie Mark G | Chief Scientific Officer | Oct 31, 2016 | Option Exercise | 882,000 |
| OLANOFF LAWRENCE S | Director | Sep 06, 2016 | Sale | 43,904 |
| Consylman Gina | Chief Accounting Officer | Aug 19, 2016 | Sale | 2,803 |
| OLANOFF LAWRENCE S | Director | Jun 03, 2016 | Sale | 28,424 |
| Gilbert Halley E | Chief Legal Officer | May 25, 2016 | Option Exercise | 59,652 |
| Gilbert Halley E | Chief Legal Officer | May 25, 2016 | Sale | 247,152 |
| Hecht Peter M | Chief Executive Officer | Mar 11, 2016 | Option Exercise | 62,400 |
| Hecht Peter M | Chief Executive Officer | Mar 09, 2016 | Option Exercise | 344,432 |
| Hecht Peter M | Chief Executive Officer | Mar 10, 2016 | Option Exercise | 62,400 |
| Hecht Peter M | Chief Executive Officer | Mar 10, 2016 | Sale | 425,200 |
| Hecht Peter M | Chief Executive Officer | Mar 11, 2016 | Sale | 426,400 |
| Hecht Peter M | Chief Executive Officer | Mar 09, 2016 | Sale | 434,800 |
| Currie Mark G | Chief Scientific Officer | Mar 09, 2016 | Option Exercise | 251,001 |
| Currie Mark G | Chief Scientific Officer | Mar 09, 2016 | Sale | 1,629,000 |
| OLANOFF LAWRENCE S | Director | Mar 07, 2016 | Sale | 24,442 |
| MCCOURT Thomas A | Chief Commercial Officer | Feb 24, 2016 | Sale | 13,600 |
| Graney Thomas | Chief Financial Officer | Feb 24, 2016 | Sale | 4,786 |
| Consylman Gina | Chief Accounting Officer | Feb 24, 2016 | Sale | 3,570 |
| Gilbert Halley E | Chief Legal Officer | Feb 24, 2016 | Sale | 23,613 |
| Currie Mark G | Chief Scientific Officer | Feb 24, 2016 | Option Exercise | 234,000 |
| Currie Mark G | Chief Scientific Officer | Feb 24, 2016 | Sale | 1,297,809 |
| Owens Edward P | Director | Feb 24, 2016 | Buy | 83,200 |
| Currie Mark G | Chief Scientific Officer | Jan 04, 2016 | Option Exercise | 99,999 |
| Hecht Peter M | Chief Executive Officer | Dec 11, 2015 | Option Exercise | 390,000 |
| Hecht Peter M | Chief Executive Officer | Dec 15, 2015 | Sale | 812,737 |
| OLANOFF LAWRENCE S | Director | Dec 07, 2015 | Sale | 25,894 |
| Hecht Peter M | Chief Executive Officer | Oct 28, 2015 | Option Exercise | 199,997 |
| OLANOFF LAWRENCE S | Director | Sep 04, 2015 | Sale | 40,863 |
| ROBERTS BRYAN E | Director | Jun 15, 2015 | Option Exercise | 1,749 |
| Fanucci Marsha | Director | Mar 18, 2015 | Sale | 491,396 |
| Hecht Peter M | Chief Executive Officer | Mar 17, 2015 | Option Exercise | 195,000 |
| Hecht Peter M | Chief Executive Officer | Mar 16, 2015 | Option Exercise | 117,000 |
| Hecht Peter M | Chief Executive Officer | Mar 16, 2015 | Sale | 1,170,000 |
| Hecht Peter M | Chief Executive Officer | Mar 17, 2015 | Sale | 1,953,154 |
| ROBERTS BRYAN E | Director | Mar 13, 2015 | Option Exercise | 2,487 |
| COOK JOSEPH C JR | Director | Mar 11, 2015 | Sale | 40,378 |
| COOK JOSEPH C JR | Director | Mar 12, 2015 | Sale | 51,018 |
| ROBERTS BRYAN E | Director | Mar 09, 2015 | Sale | 101,595 |
| ROBERTS BRYAN E | Director | Mar 09, 2015 | Sale | 2,312 |
| ROBERTS BRYAN E | Director | Mar 10, 2015 | Sale | 1,353,847 |
| ROBERTS BRYAN E | Director | Mar 10, 2015 | Sale | 1,582 |
| Hecht Peter M | Chief Executive Officer | Mar 02, 2015 | Option Exercise | 21,696 |
| Hecht Peter M | Chief Executive Officer | Feb 27, 2015 | Option Exercise | 126,000 |
| Hecht Peter M | Chief Executive Officer | Mar 03, 2015 | Option Exercise | 9,672 |
| Hecht Peter M | Chief Executive Officer | Feb 27, 2015 | Sale | 679,432 |
| Hecht Peter M | Chief Executive Officer | Mar 03, 2015 | Sale | 97,402 |
| Hecht Peter M | Chief Executive Officer | Mar 02, 2015 | Sale | 222,528 |
| COOK JOSEPH C JR | Director | Feb 20, 2015 | Sale | 40,638 |
| COOK JOSEPH C JR | Director | Feb 19, 2015 | Sale | 513,240 |
| Currie Mark G | Chief Scientific Officer | Feb 19, 2015 | Option Exercise | 15,000 |
| Currie Mark G | Chief Scientific Officer | Feb 19, 2015 | Sale | 391,750 |
| Higgins Michael J | Chief Operating Officer | Dec 23, 2014 | Option Exercise | 45,399 |
| Higgins Michael J | Chief Operating Officer | Dec 16, 2014 | Option Exercise | 47,002 |
| Higgins Michael J | Chief Operating Officer | Dec 16, 2014 | Sale | 223,978 |
| ROBERTS BRYAN E | Director | Dec 15, 2014 | Option Exercise | 2,493 |
| ROBERTS BRYAN E | Director | Dec 15, 2014 | Sale | 18,072 |
| ROBERTS BRYAN E | Director | Dec 12, 2014 | Sale | 282,784 |
| COOK JOSEPH C JR | Director | Dec 11, 2014 | Sale | 1,500 |
| Higgins Michael J | Chief Operating Officer | Nov 24, 2014 | Option Exercise | 110,601 |
| Higgins Michael J | Chief Operating Officer | Nov 24, 2014 | Sale | 974,848 |
| Currie Mark G | Chief Scientific Officer | Nov 13, 2014 | Option Exercise | 12,000 |
| Currie Mark G | Chief Scientific Officer | Nov 13, 2014 | Sale | 272,600 |
| ROBERTS BRYAN E | Director | Sep 15, 2014 | Option Exercise | 2,493 |
| COOK JOSEPH C JR | Director | Jun 16, 2014 | Sale | 9,000 |
| ROBERTS BRYAN E | Director | Jun 13, 2014 | Option Exercise | 2,492 |
| ROBERTS BRYAN E | Director | Jun 12, 2014 | Sale | 2,848,000 |
| ROBERTS BRYAN E | Director | Jun 09, 2014 | Sale | 4,194,044 |
| ROBERTS BRYAN E | Director | May 30, 2014 | Sale | 5,969,956 |
| Higgins Michael J | Chief Operating Officer | May 29, 2014 | Sale | 728,000 |
| Currie Mark G | Chief Scientific Officer | May 22, 2014 | Option Exercise | 15,000 |
| Currie Mark G | Chief Scientific Officer | May 22, 2014 | Sale | 348,250 |
| Currie Mark G | Chief Scientific Officer | Apr 24, 2014 | Option Exercise | 15,000 |
| Currie Mark G | Chief Scientific Officer | Apr 24, 2014 | Sale | 291,750 |
| ROBERTS BRYAN E | Director | Mar 14, 2014 | Option Exercise | 2,488 |
| Hecht Peter M | Chief Executive Officer | Feb 20, 2014 | Option Exercise | 135,000 |
| Currie Mark G | Chief Scientific Officer | Feb 18, 2014 | Option Exercise | 9,000 |
| Currie Mark G | Chief Scientific Officer | Feb 18, 2014 | Sale | 216,450 |
| Currie Mark G | Chief Scientific Officer | Jan 23, 2014 | Option Exercise | 12,000 |
| Currie Mark G | Chief Scientific Officer | Jan 23, 2014 | Sale | 287,600 |
| ROBERTS BRYAN E | Director | Jan 14, 2014 | Sale | 266,484 |
| ROBERTS BRYAN E | Director | Jan 09, 2014 | Sale | 3,334,447 |
| ROBERTS BRYAN E | Director | Jan 13, 2014 | Sale | 3,198,348 |
| ROBERTS BRYAN E | Director | Jan 10, 2014 | Sale | 3,936,000 |
| ROBERTS BRYAN E | Director | Jan 06, 2014 | Sale | 19,296 |
| ROBERTS BRYAN E | Director | Jan 03, 2014 | Sale | 646,739 |
| ROBERTS BRYAN E | Director | Dec 31, 2013 | Option Exercise | 2,496 |
| MCGUIRE TERRANCE | Director | Nov 07, 2013 | Sale | 18,457 |
| MCGUIRE TERRANCE | Director | Nov 07, 2013 | Sale | 519 |
| ROBERTS BRYAN E | Director | Sep 30, 2013 | Option Exercise | 2,498 |
| Hecht Peter M | Chief Executive Officer | Jul 08, 2013 | Option Exercise | 60,000 |
| ROBERTS BRYAN E | Director | Jun 28, 2013 | Option Exercise | 2,492 |
| Higgins Michael J | Chief Operating Officer | Jun 14, 2013 | Option Exercise | 86,460 |
| Higgins Michael J | Chief Operating Officer | Jun 17, 2013 | Option Exercise | 68,540 |
| Higgins Michael J | Chief Operating Officer | Jun 17, 2013 | Sale | 69,856 |
| Higgins Michael J | Chief Operating Officer | Jun 14, 2013 | Sale | 1,691,734 |
| FMR LLC | 10% Owner | Mar 28, 2013 | Sale | 2,908,530 |
| ROBERTS BRYAN E | Director | Mar 28, 2013 | Option Exercise | 2,487 |
| MCCOURT Thomas A | Chief Commercial Officer | Mar 11, 2013 | Option Exercise | 219,200 |
| MCCOURT Thomas A | Chief Commercial Officer | Mar 11, 2013 | Sale | 680,000 |
| Higgins Michael J | Chief Operating Officer | Mar 06, 2013 | Option Exercise | 60,000 |
| Higgins Michael J | Chief Operating Officer | Mar 05, 2013 | Sale | 778,500 |
| Currie Mark G | Chief Scientific Officer | Feb 20, 2013 | Option Exercise | 60,000 |
| ROBERTS BRYAN E | Director | Dec 31, 2012 | Option Exercise | 2,493 |
| COOK JOSEPH C JR | Director | Nov 19, 2012 | Option Exercise | 24,000 |
| WALSH CHRISTOPHER T PHD | Director | Nov 07, 2012 | Option Exercise | 172,400 |
| Hecht Peter M | Chief Executive Officer | Nov 05, 2012 | Buy | 582,500 |
| FMR LLC | 10% Owner | Oct 12, 2012 | Sale | 1,580,743 |
| FMR LLC | 10% Owner | Oct 11, 2012 | Sale | 778,310 |
| FMR LLC | 10% Owner | Oct 15, 2012 | Sale | 461,541 |
| FMR LLC | 10% Owner | Oct 04, 2012 | Sale | 9,100 |
| FMR LLC | 10% Owner | Oct 08, 2012 | Sale | 76,432 |
| FMR LLC | 10% Owner | Oct 05, 2012 | Sale | 165,746 |
| FMR LLC | 10% Owner | Oct 03, 2012 | Sale | 81,900 |
| FMR LLC | 10% Owner | Oct 01, 2012 | Sale | 27,333 |
| ROBERTS BRYAN E | Director | Sep 28, 2012 | Option Exercise | 2,492 |
| FMR LLC | 10% Owner | Sep 27, 2012 | Sale | 577,342 |
| FMR LLC | 10% Owner | Sep 26, 2012 | Sale | 674,363 |
| FMR LLC | 10% Owner | Sep 25, 2012 | Sale | 500,634 |
| FMR LLC | 10% Owner | Sep 24, 2012 | Sale | 1,133,011 |
| FMR LLC | 10% Owner | Sep 21, 2012 | Sale | 1,775,070 |
| FMR LLC | 10% Owner | Sep 19, 2012 | Sale | 745,379 |
| FMR LLC | 10% Owner | Sep 18, 2012 | Sale | 664,317 |
| FMR LLC | 10% Owner | Sep 20, 2012 | Sale | 733,613 |
| FMR LLC | 10% Owner | Sep 13, 2012 | Sale | 385,491 |
| FMR LLC | 10% Owner | Sep 17, 2012 | Sale | 519,909 |
| FMR LLC | 10% Owner | Sep 14, 2012 | Sale | 1,115,719 |
| FMR LLC | 10% Owner | Aug 30, 2012 | Sale | 317,120 |
| FMR LLC | 10% Owner | Jul 31, 2012 | Sale | 69,971 |
| FMR LLC | 10% Owner | Jul 30, 2012 | Sale | 27,839 |
| FMR LLC | 10% Owner | Jul 27, 2012 | Sale | 554,012 |
| FMR LLC | 10% Owner | Jul 26, 2012 | Sale | 225,624 |
| FMR LLC | 10% Owner | Jul 25, 2012 | Sale | 2,600 |
| FMR LLC | 10% Owner | Jul 20, 2012 | Sale | 209,882 |
| FMR LLC | 10% Owner | Jul 24, 2012 | Sale | 89,743 |
| FMR LLC | 10% Owner | Jul 19, 2012 | Sale | 630,828 |
| FMR LLC | 10% Owner | Jul 18, 2012 | Sale | 242,029 |
| FMR LLC | 10% Owner | Jul 17, 2012 | Sale | 107,716 |
| FMR LLC | 10% Owner | Jul 16, 2012 | Sale | 202,956 |
| FMR LLC | 10% Owner | Jul 13, 2012 | Sale | 275,673 |
| FMR LLC | 10% Owner | Jul 12, 2012 | Sale | 7,999 |
| FMR LLC | 10% Owner | Jul 09, 2012 | Sale | 193,497 |
| FMR LLC | 10% Owner | Jul 10, 2012 | Sale | 67,934 |
| FMR LLC | 10% Owner | Jul 06, 2012 | Sale | 251,125 |
| FMR LLC | 10% Owner | Jul 05, 2012 | Sale | 237,423 |
| FMR LLC | 10% Owner | Jul 03, 2012 | Sale | 131,107 |
| FMR LLC | 10% Owner | Jul 02, 2012 | Sale | 204,624 |
| FMR LLC | 10% Owner | Jun 29, 2012 | Sale | 503,982 |
| FMR LLC | 10% Owner | Jun 28, 2012 | Sale | 73,520 |
| ROBERTS BRYAN E | Director | Jun 29, 2012 | Option Exercise | 2,494 |
| Hecht Peter M | Chief Executive Officer | Apr 05, 2012 | Option Exercise | 61,500 |
| ROBERTS BRYAN E | Director | Mar 30, 2012 | Option Exercise | 2,489 |
| Ridgeback Capital Investments L.P. | 10% Owner | Feb 06, 2012 | Sale | 698,989 |
| Ridgeback Capital Investments L.P. | 10% Owner | Feb 03, 2012 | Sale | 924,279 |
| Ridgeback Capital Investments L.P. | 10% Owner | Feb 02, 2012 | Sale | 49,599 |
| WALSH CHRISTOPHER T PHD | Director | Jan 13, 2012 | Option Exercise | 1,860 |
| Higgins Michael J | Chief Operating Officer | Sep 02, 2011 | Option Exercise | 40,000 |
| Higgins Michael J | Chief Operating Officer | Jun 24, 2011 | Sale | 398,500 |
| Ridgeback Capital Investments L.P. | 10% Owner | Jun 23, 2011 | Sale | 8,095,000 |
| Currie Mark G | Chief Scientific Officer | Apr 21, 2011 | Option Exercise | 12,000 |
| Currie Mark G | Chief Scientific Officer | Apr 21, 2011 | Sale | 303,400 |
| Currie Mark G | Chief Scientific Officer | Apr 14, 2011 | Option Exercise | 9,082 |
| Currie Mark G | Chief Scientific Officer | Apr 14, 2011 | Sale | 227,055 |
| Currie Mark G | Chief Scientific Officer | Apr 13, 2011 | Option Exercise | 14,558 |
| Currie Mark G | Chief Scientific Officer | Apr 11, 2011 | Option Exercise | 360 |
| Currie Mark G | Chief Scientific Officer | Apr 13, 2011 | Sale | 363,945 |
| Currie Mark G | Chief Scientific Officer | Apr 11, 2011 | Sale | 9,000 |
| Currie Mark G | Chief Scientific Officer | Mar 21, 2011 | Option Exercise | 24,000 |
| Currie Mark G | Chief Scientific Officer | Mar 21, 2011 | Sale | 528,400 |
| Currie Mark G | Chief Scientific Officer | Mar 03, 2011 | Option Exercise | 4,633 |
| Currie Mark G | Chief Scientific Officer | Mar 03, 2011 | Sale | 96,590 |
| Currie Mark G | Chief Scientific Officer | Feb 28, 2011 | Option Exercise | 1,140 |
| Currie Mark G | Chief Scientific Officer | Feb 25, 2011 | Option Exercise | 227 |
| Currie Mark G | Chief Scientific Officer | Feb 28, 2011 | Sale | 23,750 |
| Currie Mark G | Chief Scientific Officer | Feb 25, 2011 | Sale | 4,738 |
| Currie Mark G | Chief Scientific Officer | Feb 23, 2011 | Option Exercise | 3,128 |
| Currie Mark G | Chief Scientific Officer | Feb 22, 2011 | Option Exercise | 14,872 |
| Currie Mark G | Chief Scientific Officer | Feb 23, 2011 | Sale | 62,881 |
| Currie Mark G | Chief Scientific Officer | Feb 22, 2011 | Sale | 293,714 |
| WALSH CHRISTOPHER T PHD | Director | Feb 09, 2011 | Option Exercise | 1,860 |