Insider Transactions for IONIS PHARMACEUTICALS INC (IONS)

Owner Relationship Date Transaction Cost # Shares Value($) Total Shares Form 4
MUTO FREDERICK T Director Jun 30, 2020 Option Exercise $9.22 15,000 138,300 27,683 Jul 02, 2020, 05:11 PM
Castleman Breaux Director Jun 25, 2020 Option Exercise $26.66 10,000 266,600 25,183 Jun 29, 2020, 09:47 PM
Castleman Breaux Director Jun 25, 2020 Sale $60.00 10,000 600,000 15,183 Jun 29, 2020, 09:47 PM
BENNETT C FRANK EVP, Chief Scientific Officer Jun 25, 2020 Option Exercise $39.87 15,000 598,050 47,364 Jun 29, 2020, 09:47 PM
BENNETT C FRANK EVP, Chief Scientific Officer Jun 25, 2020 Sale $59.77 15,000 896,505 32,364 Jun 29, 2020, 09:47 PM
CROOKE STANLEY T Exec Chairman of the Board Jun 25, 2020 Sale $60.11 9,914 595,907 2,021 Jun 26, 2020, 07:47 PM
CROOKE STANLEY T Exec Chairman of the Board Jun 24, 2020 Sale $58.80 5,000 294,000 11,935 Jun 26, 2020, 07:47 PM
BERTHELSEN SPENCER R Director Jun 23, 2020 Option Exercise $9.22 15,000 138,300 111,983 Jun 25, 2020, 07:28 PM
BERTHELSEN SPENCER R Director Jun 23, 2020 Sale $58.76 15,000 881,400 96,983 Jun 25, 2020, 07:28 PM
CROOKE STANLEY T Exec Chairman of the Board Jun 17, 2020 Sale $57.90 15,000 868,521 26,935 Jun 19, 2020, 07:03 PM
CROOKE STANLEY T Exec Chairman of the Board Jun 19, 2020 Sale $58.33 10,000 583,250 16,935 Jun 19, 2020, 07:03 PM
CROOKE STANLEY T Exec Chairman of the Board Jun 17, 2020 Sale $58.25 2,000 116,500 3,581 Jun 19, 2020, 07:03 PM
CROOKE STANLEY T Exec Chairman of the Board Mar 25, 2020 Sale $47.00 1,000 47,000 5,581 Mar 27, 2020, 07:05 PM
CROOKE STANLEY T Exec Chairman of the Board Mar 25, 2020 Sale $47.00 15,000 705,000 41,935 Mar 27, 2020, 07:05 PM
CROOKE STANLEY T Exec Chairman of the Board Mar 17, 2020 Sale $44.75 20,000 895,000 87,356 Mar 27, 2020, 07:01 PM
CROOKE STANLEY T Exec Chairman of the Board Mar 19, 2020 Sale $45.00 1,000 45,000 6,581 Mar 23, 2020, 06:17 PM
CROOKE STANLEY T Exec Chairman of the Board Mar 19, 2020 Sale $45.17 15,000 677,546 61,545 Mar 23, 2020, 06:17 PM
CROOKE STANLEY T Exec Chairman of the Board Mar 17, 2020 Sale $44.75 20,390 912,355 86,966 Mar 19, 2020, 01:55 PM
Swayze Eric SVP, Research Feb 29, 2020 Option Exercise $43.16 378 16,316 5,301 Mar 03, 2020, 07:18 PM
O'NEIL PATRICK R. SVP & General Counsel Feb 29, 2020 Option Exercise $43.16 289 12,474 21,009 Mar 03, 2020, 07:16 PM
Monia Brett P Chief Executive Officer Feb 29, 2020 Option Exercise $43.16 314 13,553 28,957 Mar 03, 2020, 07:14 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Feb 29, 2020 Option Exercise $43.16 147 6,345 32,374 Mar 03, 2020, 07:12 PM
Geary Richard S SVP, Development Feb 29, 2020 Option Exercise $43.16 378 16,316 30,446 Mar 03, 2020, 07:11 PM
BENNETT C FRANK Chief Scientific Officer Feb 29, 2020 Option Exercise $43.16 169 7,295 32,364 Mar 03, 2020, 07:09 PM
O'NEIL PATRICK R. SVP & General Counsel Feb 10, 2020 Sale $59.60 3,882 231,367 20,720 Feb 11, 2020, 05:40 PM
Swayze Eric SVP, Research Jan 15, 2020 Option Exercise $62.06 2,367 146,896 4,923 Jan 17, 2020, 06:47 PM
PARSHALL B LYNNE Director Jan 15, 2020 Option Exercise $62.06 3,905 242,344 64,797 Jan 17, 2020, 06:42 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 15, 2020 Option Exercise $62.06 4,277 265,431 24,602 Jan 17, 2020, 06:39 PM
Monia Brett P Chief Executive Officer Jan 15, 2020 Option Exercise $62.06 7,563 469,360 28,643 Jan 17, 2020, 06:36 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 15, 2020 Option Exercise $62.06 4,277 265,431 32,227 Jan 17, 2020, 06:33 PM
Geary Richard S SVP, Development Jan 15, 2020 Option Exercise $62.06 4,654 288,827 30,068 Jan 17, 2020, 06:30 PM
CROOKE STANLEY T Executive Chairman of Board Jan 15, 2020 Option Exercise $62.06 1,268 78,692 7,581 Jan 17, 2020, 06:28 PM
CROOKE STANLEY T Executive Chairman of Board Jan 15, 2020 Option Exercise $62.06 17,342 1,076,245 91,935 Jan 17, 2020, 06:28 PM
BENNETT C FRANK Chief Scientific Officer Jan 15, 2020 Option Exercise $62.06 4,162 258,294 32,195 Jan 17, 2020, 06:11 PM
Monia Brett P Chief Executive Officer Jan 02, 2020 Sale $60.25 173 10,423 16,285 Jan 03, 2020, 07:04 PM
KLEIN JOSEPH III Director Dec 23, 2019 Option Exercise $35.53 1,000 35,530 13,683 Dec 23, 2019, 07:28 PM
KLEIN JOSEPH III Director Dec 23, 2019 Sale $61.87 1,000 61,874 12,683 Dec 23, 2019, 07:28 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 20, 2019 Option Exercise $61.52 6,229 383,208 24,460 Dec 20, 2019, 07:23 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 20, 2019 Option Exercise $10.82 10,634 115,060 27,251 Dec 20, 2019, 07:23 PM
KLEIN JOSEPH III Director Dec 16, 2019 Option Exercise $35.53 1,000 35,530 13,683 Dec 18, 2019, 05:07 PM
KLEIN JOSEPH III Director Dec 16, 2019 Sale $65.45 1,000 65,447 12,683 Dec 18, 2019, 05:07 PM
KLEIN JOSEPH III Director Dec 09, 2019 Option Exercise $35.53 1,000 35,530 13,683 Dec 10, 2019, 06:54 PM
KLEIN JOSEPH III Director Dec 09, 2019 Sale $63.74 1,000 63,745 12,683 Dec 10, 2019, 06:54 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 04, 2019 Option Exercise $10.82 4,566 49,404 24,117 Dec 05, 2019, 05:31 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 04, 2019 Sale $65.00 4,566 296,790 20,055 Dec 05, 2019, 05:31 PM
Geary Richard S SVP, Development Dec 04, 2019 Option Exercise $14.69 10,000 146,900 31,583 Dec 05, 2019, 05:26 PM
Geary Richard S SVP, Development Dec 04, 2019 Sale $65.00 10,000 650,000 21,583 Dec 05, 2019, 05:26 PM
KLEIN JOSEPH III Director Dec 02, 2019 Option Exercise $35.53 1,000 35,530 13,683 Dec 04, 2019, 06:26 PM
KLEIN JOSEPH III Director Dec 02, 2019 Sale $64.08 1,000 64,083 12,683 Dec 04, 2019, 06:26 PM
Geary Richard S SVP, Development Dec 02, 2019 Option Exercise $14.69 5,000 73,450 26,583 Dec 04, 2019, 06:22 PM
Geary Richard S SVP, Development Dec 02, 2019 Sale $65.06 5,000 325,287 21,583 Dec 04, 2019, 06:22 PM
KLEIN JOSEPH III Director Nov 25, 2019 Sale $62.90 812 51,075 12,683 Nov 26, 2019, 05:43 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 25, 2019 Option Exercise $10.82 4,000 43,280 24,055 Nov 26, 2019, 05:40 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 25, 2019 Sale $62.50 4,000 250,000 20,055 Nov 26, 2019, 05:40 PM
KLEIN JOSEPH III Director Nov 20, 2019 Sale $60.00 2,000 120,000 13,495 Nov 21, 2019, 06:40 PM
Monia Brett P COO & SVP, Translational Med Nov 20, 2019 Sale $60.01 5,776 346,618 16,458 Nov 21, 2019, 06:38 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 19, 2019 Option Exercise $10.82 4,000 43,280 24,055 Nov 21, 2019, 06:36 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 19, 2019 Sale $58.80 4,000 235,200 20,055 Nov 21, 2019, 06:36 PM
CROOKE STANLEY T Chairman and CEO Aug 20, 2019 Option Exercise $39.87 10,000 398,700 79,634 Aug 22, 2019, 06:41 PM
CROOKE STANLEY T Chairman and CEO Aug 21, 2019 Option Exercise $39.87 10,000 398,700 79,634 Aug 22, 2019, 06:41 PM
CROOKE STANLEY T Chairman and CEO Aug 20, 2019 Option Exercise $39.87 2,000 79,740 7,532 Aug 22, 2019, 06:41 PM
CROOKE STANLEY T Chairman and CEO Aug 20, 2019 Sale $71.00 2,000 142,000 5,532 Aug 22, 2019, 06:41 PM
CROOKE STANLEY T Chairman and CEO Aug 20, 2019 Sale $71.00 10,000 710,000 69,634 Aug 22, 2019, 06:41 PM
CROOKE STANLEY T Chairman and CEO Aug 21, 2019 Sale $72.15 10,000 721,500 69,634 Aug 22, 2019, 06:41 PM
CROOKE STANLEY T Chairman & CEO Jul 18, 2019 Option Exercise $39.87 10,000 398,700 79,634 Jul 22, 2019, 05:34 PM
CROOKE STANLEY T Chairman & CEO Jul 18, 2019 Sale $70.25 10,000 702,506 69,634 Jul 22, 2019, 05:34 PM
McDevitt Damien Chief Business Officer Jul 15, 2019 Option Exercise $67.86 1,225 83,129 2,573 Jul 17, 2019, 05:39 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jul 01, 2019 Option Exercise $45.70 161 7,358 16,834 Jul 02, 2019, 08:56 PM
Monia Brett P Chief Operating Officer Jul 01, 2019 Option Exercise $45.70 173 7,907 22,444 Jul 02, 2019, 08:50 PM
Monia Brett P Chief Operating Officer Jul 02, 2019 Sale $66.40 210 13,944 22,234 Jul 02, 2019, 08:50 PM
HOUGEN ELIZABETH L SVP Finance & CFO Jul 01, 2019 Option Exercise $45.70 105 4,799 20,055 Jul 02, 2019, 08:45 PM
Geary Richard S SVP, Development Jul 01, 2019 Option Exercise $45.70 141 6,444 21,583 Jul 02, 2019, 08:43 PM
BENNETT C FRANK SVP, Antisense Research Jul 01, 2019 Option Exercise $45.70 118 5,393 24,646 Jul 02, 2019, 08:39 PM
McDevitt Damien Chief Business Officer Jul 01, 2019 Option Exercise $45.70 256 11,700 256 Jul 02, 2019, 08:35 PM
BERTHELSEN SPENCER R Director Jun 24, 2019 Option Exercise $16.32 15,000 244,800 103,784 Jun 26, 2019, 06:52 PM
BERTHELSEN SPENCER R Director Jun 24, 2019 Sale $63.67 15,000 955,113 94,094 Jun 26, 2019, 06:52 PM
MUTO FREDERICK T Director Jun 04, 2019 Option Exercise $16.32 15,000 244,800 24,794 Jun 06, 2019, 06:35 PM
MUTO FREDERICK T Director Jun 04, 2019 Sale $65.29 15,000 979,350 9,794 Jun 06, 2019, 06:35 PM
MUTO FREDERICK T Director May 06, 2019 Option Exercise $24.42 8,000 195,360 17,794 May 08, 2019, 06:16 PM
MUTO FREDERICK T Director May 06, 2019 Sale $72.75 8,000 582,002 9,794 May 08, 2019, 06:16 PM
PARSHALL B LYNNE Director Apr 29, 2019 Option Exercise $39.87 50,000 1,993,500 102,677 May 01, 2019, 05:48 PM
PARSHALL B LYNNE Director Apr 29, 2019 Sale $75.01 50,000 3,750,635 52,677 May 01, 2019, 05:48 PM
CROOKE STANLEY T Chairman and CEO Apr 15, 2019 Option Exercise $10.82 1,000 10,820 6,532 Apr 17, 2019, 07:30 PM
CROOKE STANLEY T Chairman and CEO Apr 16, 2019 Option Exercise $31.15 1,000 31,155 6,232 Apr 17, 2019, 07:30 PM
CROOKE STANLEY T Chairman and CEO Apr 15, 2019 Option Exercise $14.69 10,000 146,900 79,634 Apr 17, 2019, 07:30 PM
CROOKE STANLEY T Chairman and CEO Apr 16, 2019 Option Exercise $31.46 20,000 629,198 82,954 Apr 17, 2019, 07:30 PM
CROOKE STANLEY T Chairman and CEO Apr 15, 2019 Sale $85.25 10,000 852,500 69,634 Apr 17, 2019, 07:30 PM
CROOKE STANLEY T Chairman and CEO Apr 16, 2019 Sale $84.62 20,000 1,692,500 69,634 Apr 17, 2019, 07:30 PM
CROOKE STANLEY T Chairman and CEO Apr 15, 2019 Sale $85.25 1,000 85,250 5,532 Apr 17, 2019, 07:30 PM
CROOKE STANLEY T Chairman and CEO Apr 16, 2019 Sale $84.75 1,000 84,750 5,532 Apr 17, 2019, 07:30 PM
Geary Richard S SVP, Development Apr 08, 2019 Option Exercise $42.53 46,240 1,966,466 45,442 Apr 10, 2019, 06:24 PM
Geary Richard S SVP, Development Apr 08, 2019 Sale $84.01 46,240 3,884,753 21,442 Apr 10, 2019, 06:24 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Apr 04, 2019 Option Exercise $56.76 36,622 2,078,809 35,165 Apr 05, 2019, 07:29 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Apr 03, 2019 Option Exercise $61.68 7,654 472,099 27,327 Apr 05, 2019, 07:29 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Apr 05, 2019 Option Exercise $61.68 2,252 138,903 18,925 Apr 05, 2019, 07:29 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Apr 03, 2019 Sale $84.83 7,654 649,289 19,673 Apr 05, 2019, 07:29 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Apr 05, 2019 Sale $84.75 2,252 190,857 16,673 Apr 05, 2019, 07:29 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Apr 04, 2019 Sale $83.79 39,622 3,319,929 19,673 Apr 05, 2019, 07:29 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Mar 18, 2019 Option Exercise $61.57 28,800 1,773,216 48,473 Mar 20, 2019, 06:15 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Mar 18, 2019 Sale $78.79 28,800 2,269,187 19,673 Mar 20, 2019, 06:15 PM
WENDER JOSEPH H Director Mar 19, 2019 Sale $79.63 10,000 796,258 58,916 Mar 20, 2019, 06:05 PM
PARSHALL B LYNNE Director Mar 12, 2019 Option Exercise $39.87 8,334 332,277 61,011 Mar 14, 2019, 06:24 PM
PARSHALL B LYNNE Director Mar 12, 2019 Sale $75.00 8,334 625,050 52,677 Mar 14, 2019, 06:24 PM
PARSHALL B LYNNE Director Feb 27, 2019 Option Exercise $39.87 8,333 332,237 61,010 Mar 01, 2019, 05:56 PM
PARSHALL B LYNNE Director Feb 27, 2019 Sale $70.00 8,333 583,310 52,677 Mar 01, 2019, 05:56 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Feb 27, 2019 Option Exercise $45.11 26,800 1,208,952 33,773 Mar 01, 2019, 05:40 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Feb 27, 2019 Sale $68.01 26,800 1,822,580 19,673 Mar 01, 2019, 05:40 PM
CROOKE STANLEY T Chairman and CEO Feb 26, 2019 Option Exercise $39.87 37,000 1,475,190 106,634 Feb 27, 2019, 07:31 PM
CROOKE STANLEY T Chairman and CEO Feb 25, 2019 Option Exercise $39.87 40,000 1,594,800 109,634 Feb 27, 2019, 07:31 PM
CROOKE STANLEY T Chairman and CEO Feb 26, 2019 Sale $61.54 37,000 2,276,799 69,634 Feb 27, 2019, 07:31 PM
CROOKE STANLEY T Chairman and CEO Feb 25, 2019 Sale $60.07 40,000 2,402,700 69,634 Feb 27, 2019, 07:31 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Feb 12, 2019 Option Exercise $39.87 275 10,964 19,948 Feb 14, 2019, 06:01 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Feb 12, 2019 Sale $59.50 275 16,363 19,673 Feb 14, 2019, 06:01 PM
CROOKE STANLEY T Chairman and CEO Feb 13, 2019 Option Exercise $33.12 6,904 228,666 10,832 Feb 14, 2019, 05:57 PM
CROOKE STANLEY T Chairman and CEO Feb 13, 2019 Option Exercise $39.87 40,000 1,594,800 109,634 Feb 14, 2019, 05:57 PM
CROOKE STANLEY T Chairman and CEO Feb 13, 2019 Sale $60.00 6,904 414,240 5,532 Feb 14, 2019, 05:57 PM
CROOKE STANLEY T Chairman and CEO Feb 13, 2019 Sale $60.10 40,000 2,404,028 69,634 Feb 14, 2019, 05:57 PM
Geary Richard S SVP, Development Feb 13, 2019 Sale $60.00 999 59,940 21,442 Feb 14, 2019, 05:51 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Feb 01, 2019 Option Exercise $39.87 4,000 159,480 23,673 Feb 05, 2019, 06:05 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Feb 05, 2019 Option Exercise $39.87 15,600 621,972 35,273 Feb 05, 2019, 06:05 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Feb 05, 2019 Sale $59.50 15,600 928,200 19,673 Feb 05, 2019, 06:05 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Feb 01, 2019 Sale $58.29 4,000 233,160 19,673 Feb 05, 2019, 06:05 PM
BENNETT C FRANK SVP, Antisense Research Feb 01, 2019 Option Exercise $14.69 9,013 132,401 33,541 Feb 05, 2019, 05:59 PM
BENNETT C FRANK SVP, Antisense Research Feb 01, 2019 Sale $58.29 9,013 525,368 24,528 Feb 05, 2019, 05:59 PM
BENNETT C FRANK SVP, Antisense Research Jan 15, 2019 Option Exercise $58.26 2,818 164,177 24,400 Jan 17, 2019, 07:39 PM
Geary Richard S SVP, Development Jan 15, 2019 Option Exercise $58.26 2,908 169,420 22,034 Jan 17, 2019, 07:36 PM
HOUGEN ELIZABETH L SVP Finance & CFO Jan 15, 2019 Option Exercise $58.26 2,842 165,575 19,823 Jan 17, 2019, 07:35 PM
Monia Brett P Chief Operating Officer Jan 15, 2019 Option Exercise $58.26 3,572 208,105 22,275 Jan 17, 2019, 07:34 PM
CROOKE STANLEY T Chairman and CEO Jan 15, 2019 Option Exercise $58.26 942 54,881 5,532 Jan 17, 2019, 07:27 PM
CROOKE STANLEY T Chairman and CEO Jan 15, 2019 Option Exercise $58.26 12,686 739,086 69,634 Jan 17, 2019, 07:27 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jan 15, 2019 Option Exercise $58.26 2,734 159,283 19,607 Jan 17, 2019, 07:24 PM
PARSHALL B LYNNE Director Jan 15, 2019 Option Exercise $58.26 6,159 358,823 52,677 Jan 17, 2019, 07:19 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jan 01, 2019 Option Exercise $36.45 66 2,406 14,584 Jan 03, 2019, 07:50 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jan 03, 2019 Option Exercise $37.23 4,400 163,808 18,584 Jan 03, 2019, 07:50 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jan 03, 2019 Sale $54.80 4,400 241,120 14,584 Jan 03, 2019, 07:50 PM
HOUGEN ELIZABETH L SVP Finance & CFO Jan 01, 2019 Option Exercise $36.45 127 4,629 14,901 Jan 03, 2019, 07:44 PM
Monia Brett P Chief Operating Officer Jan 01, 2019 Option Exercise $36.45 210 7,654 16,051 Jan 03, 2019, 07:42 PM
Monia Brett P Chief Operating Officer Jan 02, 2019 Sale $53.50 214 11,449 15,837 Jan 03, 2019, 07:42 PM
Geary Richard S SVP, Development Jan 01, 2019 Option Exercise $36.45 407 14,834 17,264 Jan 03, 2019, 07:34 PM
BENNETT C FRANK SVP, Antisense Research Jan 01, 2019 Option Exercise $36.45 128 4,665 19,524 Jan 03, 2019, 07:32 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 18, 2018 Option Exercise $7.25 2,000 14,500 16,774 Dec 20, 2018, 05:55 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 19, 2018 Option Exercise $7.25 2,063 14,957 16,837 Dec 20, 2018, 05:55 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 19, 2018 Sale $52.05 2,063 107,379 14,774 Dec 20, 2018, 05:55 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 18, 2018 Sale $52.00 2,000 104,000 14,774 Dec 20, 2018, 05:55 PM
Monia Brett P Chief Operating Officer Nov 23, 2018 Option Exercise $14.69 34,000 499,460 49,841 Nov 26, 2018, 08:01 PM
Monia Brett P Chief Operating Officer Nov 23, 2018 Sale $55.00 34,000 1,870,058 15,841 Nov 26, 2018, 08:01 PM
BENNETT C FRANK SVP, Antisense Research Nov 01, 2018 Option Exercise $14.69 12,500 183,625 31,896 Nov 01, 2018, 07:34 PM
BENNETT C FRANK SVP, Antisense Research Nov 01, 2018 Sale $49.54 12,500 619,245 19,396 Nov 01, 2018, 07:34 PM
Monia Brett P Chief Operating Officer Aug 27, 2018 Option Exercise $7.23 16,493 119,274 24,834 Aug 29, 2018, 04:49 PM
Monia Brett P Chief Operating Officer Aug 27, 2018 Sale $54.00 16,493 890,622 15,841 Aug 29, 2018, 04:49 PM
BENNETT C FRANK SVP, Antisense Research Aug 08, 2018 Option Exercise $14.68 12,500 183,528 31,883 Aug 09, 2018, 06:34 PM
BENNETT C FRANK SVP, Antisense Research Aug 08, 2018 Sale $45.00 12,500 562,500 19,396 Aug 09, 2018, 06:34 PM
Monia Brett P Chief Operating Officer Jul 24, 2018 Sale $47.03 156 7,337 15,841 Jul 25, 2018, 07:19 PM
WENDER JOSEPH H Director Jul 17, 2018 Option Exercise $9.26 30,000 277,800 68,916 Jul 19, 2018, 06:45 PM
BENNETT C FRANK SVP, Antisense Research Jul 01, 2018 Option Exercise $35.42 282 9,988 19,396 Jul 03, 2018, 03:35 PM
Geary Richard S SVP, Development Jul 01, 2018 Option Exercise $35.42 177 6,269 16,857 Jul 03, 2018, 03:33 PM
HOUGEN ELIZABETH L SVP Finance & CFO Jul 01, 2018 Option Exercise $35.42 274 9,705 14,774 Jul 03, 2018, 03:31 PM
Monia Brett P Chief Operating Officer Jul 01, 2018 Option Exercise $35.42 214 7,580 15,997 Jul 03, 2018, 03:30 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jul 01, 2018 Option Exercise $35.42 66 2,338 14,518 Jul 03, 2018, 03:28 PM
BERTHELSEN SPENCER R Director Jun 25, 2018 Option Exercise $13.88 15,000 208,200 100,727 Jun 25, 2018, 08:28 PM
BERTHELSEN SPENCER R Director Jun 25, 2018 Sale $42.30 15,000 634,542 91,427 Jun 25, 2018, 08:28 PM
MUTO FREDERICK T Director May 31, 2018 Option Exercise $13.88 15,000 208,200 22,127 May 31, 2018, 08:02 PM
MUTO FREDERICK T Director May 31, 2018 Sale $46.45 15,000 696,750 7,127 May 31, 2018, 08:02 PM
BENNETT C FRANK SVP, Antisense Research May 11, 2018 Option Exercise $7.25 12,500 90,625 31,614 May 11, 2018, 09:06 PM
BENNETT C FRANK SVP, Antisense Research May 11, 2018 Sale $45.00 12,500 562,500 19,114 May 11, 2018, 09:06 PM
WENDER JOSEPH H Director May 11, 2018 Option Exercise $13.88 15,000 208,200 44,839 May 11, 2018, 09:00 PM
WENDER JOSEPH H Director May 11, 2018 Sale $45.31 15,000 679,614 36,249 May 11, 2018, 09:00 PM
CROOKE STANLEY T Chairman and CEO Apr 17, 2018 Option Exercise $10.82 4,000 43,280 6,128 Apr 19, 2018, 05:22 PM
CROOKE STANLEY T Chairman and CEO Apr 17, 2018 Option Exercise $14.69 9,962 146,342 56,714 Apr 19, 2018, 05:22 PM
CROOKE STANLEY T Chairman and CEO Apr 17, 2018 Sale $44.40 4,000 177,600 4,128 Apr 19, 2018, 05:22 PM
CROOKE STANLEY T Chairman and CEO Apr 17, 2018 Sale $44.40 9,962 442,313 51,733 Apr 19, 2018, 05:22 PM
KLEIN JOSEPH III Director Mar 29, 2018 Option Exercise $24.42 2,000 48,840 11,939 Mar 30, 2018, 03:51 PM
KLEIN JOSEPH III Director Mar 29, 2018 Sale $46.15 2,000 92,300 9,939 Mar 30, 2018, 03:51 PM
KLEIN JOSEPH III Director Mar 15, 2018 Option Exercise $24.42 2,000 48,840 10,839 Mar 16, 2018, 04:19 PM
KLEIN JOSEPH III Director Mar 15, 2018 Sale $51.13 2,000 102,258 9,939 Mar 16, 2018, 04:19 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Mar 12, 2018 Option Exercise $10.82 1,000 10,820 15,452 Mar 13, 2018, 09:14 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Mar 12, 2018 Sale $55.00 1,000 55,000 14,452 Mar 13, 2018, 09:14 PM
KLEIN JOSEPH III Director Feb 28, 2018 Option Exercise $35.53 3,000 106,590 12,039 Mar 01, 2018, 05:52 PM
KLEIN JOSEPH III Director Feb 28, 2018 Sale $51.91 3,000 155,727 9,939 Mar 01, 2018, 05:52 PM
KLEIN JOSEPH III Director Feb 15, 2018 Option Exercise $35.53 3,000 106,590 11,539 Feb 16, 2018, 06:00 PM
KLEIN JOSEPH III Director Feb 15, 2018 Sale $48.99 3,000 146,984 9,939 Feb 16, 2018, 06:00 PM
BENNETT C FRANK SVP, Antisense Research Feb 01, 2018 Option Exercise $7.25 12,500 90,625 31,614 Feb 01, 2018, 07:58 PM
BENNETT C FRANK SVP, Antisense Research Feb 01, 2018 Sale $52.50 12,500 656,260 19,114 Feb 01, 2018, 07:58 PM
KLEIN JOSEPH III Director Jan 30, 2018 Option Exercise $35.53 3,000 106,590 12,939 Jan 31, 2018, 04:18 PM
KLEIN JOSEPH III Director Jan 30, 2018 Sale $52.86 3,000 158,580 9,939 Jan 31, 2018, 04:18 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jan 29, 2018 Option Exercise $10.82 355 3,841 14,752 Jan 31, 2018, 04:16 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jan 29, 2018 Sale $55.00 355 19,525 14,452 Jan 31, 2018, 04:16 PM
CROOKE STANLEY T Chairman and CEO Jan 29, 2018 Option Exercise $10.82 1,000 10,820 5,128 Jan 31, 2018, 04:15 PM
CROOKE STANLEY T Chairman and CEO Jan 29, 2018 Option Exercise $14.69 10,000 146,900 61,733 Jan 31, 2018, 04:15 PM
CROOKE STANLEY T Chairman and CEO Jan 29, 2018 Sale $54.12 1,000 54,120 4,128 Jan 31, 2018, 04:15 PM
CROOKE STANLEY T Chairman and CEO Jan 29, 2018 Sale $54.12 10,000 541,200 51,733 Jan 31, 2018, 04:15 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jan 25, 2018 Option Exercise $10.82 645 6,979 15,097 Jan 29, 2018, 04:08 PM
O'NEIL PATRICK R. SVP Legal & General Counsel Jan 25, 2018 Sale $55.00 645 35,475 14,452 Jan 29, 2018, 04:08 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 16, 2018 Sale $51.76 2,724 140,994 14,500 Jan 17, 2018, 09:46 PM
KLEIN JOSEPH III Director Jan 16, 2018 Option Exercise $35.53 3,000 106,590 11,539 Jan 17, 2018, 09:28 PM
KLEIN JOSEPH III Director Jan 16, 2018 Sale $52.52 3,000 157,566 9,939 Jan 17, 2018, 09:28 PM
Geary Richard S SVP, Development Jan 16, 2018 Sale $51.76 2,723 140,942 16,680 Jan 17, 2018, 09:26 PM
PARSHALL B LYNNE Director Jan 16, 2018 Sale $51.76 5,986 309,835 38,180 Jan 17, 2018, 09:25 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 16, 2018 Sale $51.76 2,697 139,597 14,452 Jan 17, 2018, 09:25 PM
Boyce Sarah Chief Business Officer Jan 16, 2018 Sale $51.76 2,196 113,665 8,931 Jan 17, 2018, 09:23 PM
BENNETT C FRANK SVP, Antisense Research Jan 16, 2018 Sale $51.76 2,696 139,545 19,114 Jan 17, 2018, 09:22 PM
CROOKE STANLEY T Chairman and CEO Jan 15, 2018 Sale $51.76 656 33,955 4,128 Jan 17, 2018, 09:22 PM
CROOKE STANLEY T Chairman and CEO Jan 15, 2018 Sale $51.76 15,893 822,622 51,733 Jan 17, 2018, 09:22 PM
Monia Brett P COO Jan 16, 2018 Sale $51.76 2,821 146,015 15,783 Jan 17, 2018, 09:21 PM
CROOKE STANLEY T Chairman and CEO Jan 08, 2018 Option Exercise $14.69 10,000 146,900 48,014 Jan 10, 2018, 06:43 PM
CROOKE STANLEY T Chairman and CEO Jan 08, 2018 Option Exercise $10.82 1,000 10,820 4,062 Jan 10, 2018, 06:43 PM
CROOKE STANLEY T Chairman and CEO Jan 08, 2018 Sale $52.01 1,000 52,010 3,062 Jan 10, 2018, 06:43 PM
CROOKE STANLEY T Chairman and CEO Jan 08, 2018 Sale $52.01 10,000 520,100 38,014 Jan 10, 2018, 06:43 PM
CROOKE STANLEY T Chairman and CEO Jan 03, 2018 Option Exercise $14.69 20,000 293,800 58,014 Jan 05, 2018, 04:41 PM
CROOKE STANLEY T Chairman and CEO Jan 03, 2018 Option Exercise $9.21 2,000 18,413 4,158 Jan 05, 2018, 04:41 PM
CROOKE STANLEY T Chairman and CEO Jan 03, 2018 Sale $49.88 2,000 99,760 3,062 Jan 05, 2018, 04:41 PM
CROOKE STANLEY T Chairman and CEO Jan 03, 2018 Sale $50.02 20,000 1,000,400 38,014 Jan 05, 2018, 04:41 PM
PARSHALL B LYNNE COO Jan 01, 2018 Option Exercise $42.76 86 3,677 25,827 Jan 02, 2018, 08:51 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 01, 2018 Option Exercise $42.76 53 2,266 10,486 Jan 02, 2018, 08:50 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 01, 2018 Option Exercise $42.76 156 6,670 11,782 Jan 02, 2018, 08:49 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 02, 2018 Sale $50.00 163 8,150 11,619 Jan 02, 2018, 08:49 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 01, 2018 Option Exercise $42.76 100 4,276 10,492 Jan 02, 2018, 08:49 PM
Geary Richard S SVP, Development Jan 01, 2018 Option Exercise $42.76 320 13,682 12,671 Jan 02, 2018, 08:48 PM
Boyce Sarah Chief Business Officer Jan 01, 2018 Option Exercise $42.76 491 20,993 5,760 Jan 02, 2018, 08:45 PM
BENNETT C FRANK SVP, Antisense Research Jan 01, 2018 Option Exercise $42.76 106 4,532 15,147 Jan 02, 2018, 08:45 PM
KLEIN JOSEPH III Director Dec 29, 2017 Option Exercise $28.47 3,000 85,410 12,939 Jan 02, 2018, 05:50 PM
KLEIN JOSEPH III Director Dec 29, 2017 Sale $50.56 3,000 151,680 9,939 Jan 02, 2018, 05:50 PM
KLEIN JOSEPH III Director Dec 15, 2017 Option Exercise $28.47 3,000 85,410 12,939 Dec 19, 2017, 08:27 PM
KLEIN JOSEPH III Director Dec 15, 2017 Sale $51.69 3,000 155,070 9,939 Dec 19, 2017, 08:27 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 15, 2017 Option Exercise $10.29 5,000 51,450 15,392 Dec 19, 2017, 08:20 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 15, 2017 Sale $52.55 5,000 262,750 10,392 Dec 19, 2017, 08:20 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 04, 2017 Option Exercise $10.29 4,000 41,160 14,392 Dec 06, 2017, 06:36 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 04, 2017 Sale $57.00 4,000 228,000 10,392 Dec 06, 2017, 06:36 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 29, 2017 Option Exercise $10.29 6,000 61,740 16,392 Dec 01, 2017, 07:12 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 29, 2017 Sale $53.02 6,000 318,120 10,392 Dec 01, 2017, 07:12 PM
KLEIN JOSEPH III Director Nov 30, 2017 Option Exercise $28.47 3,000 85,410 12,939 Dec 01, 2017, 07:04 PM
KLEIN JOSEPH III Director Nov 30, 2017 Sale $53.55 3,000 160,650 9,939 Dec 01, 2017, 07:04 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Dec 01, 2017 Option Exercise $10.82 1,000 10,820 11,433 Dec 01, 2017, 07:03 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Dec 01, 2017 Sale $55.50 1,000 55,500 10,433 Dec 01, 2017, 07:03 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 16, 2017 Option Exercise $10.29 7,000 72,030 17,392 Nov 17, 2017, 05:57 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 16, 2017 Sale $54.35 7,000 380,450 10,392 Nov 17, 2017, 05:57 PM
KLEIN JOSEPH III Director Nov 16, 2017 Option Exercise $12.94 2,812 36,387 9,939 Nov 17, 2017, 05:57 PM
KLEIN JOSEPH III Director Nov 15, 2017 Option Exercise $28.47 2,250 64,057 9,377 Nov 17, 2017, 05:57 PM
KLEIN JOSEPH III Director Nov 15, 2017 Sale $53.56 2,250 120,510 7,127 Nov 17, 2017, 05:57 PM
KLEIN JOSEPH III Director Nov 13, 2017 Sale $55.39 3,000 166,170 7,127 Nov 14, 2017, 06:29 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Nov 01, 2017 Option Exercise $10.82 1,000 10,820 11,433 Nov 03, 2017, 05:20 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Nov 01, 2017 Sale $58.35 1,000 58,350 10,433 Nov 03, 2017, 05:20 PM
BENNETT C FRANK SVP, Antisense Research Oct 18, 2017 Option Exercise $10.29 12,250 126,052 27,291 Oct 20, 2017, 05:35 PM
BENNETT C FRANK SVP, Antisense Research Oct 18, 2017 Sale $65.00 12,250 796,250 15,041 Oct 20, 2017, 05:35 PM
PARSHALL B LYNNE COO Oct 18, 2017 Option Exercise $27.71 16,118 446,598 34,074 Oct 20, 2017, 05:34 PM
PARSHALL B LYNNE COO Oct 18, 2017 Sale $65.00 16,118 1,047,670 25,741 Oct 20, 2017, 05:34 PM
CROOKE STANLEY T Chairman and CEO Oct 13, 2017 Option Exercise $7.25 1,500 10,875 4,562 Oct 17, 2017, 05:36 PM
CROOKE STANLEY T Chairman and CEO Oct 13, 2017 Option Exercise $14.69 15,000 220,350 53,014 Oct 17, 2017, 05:36 PM
CROOKE STANLEY T Chairman and CEO Oct 13, 2017 Sale $59.46 15,000 891,900 38,014 Oct 17, 2017, 05:36 PM
CROOKE STANLEY T Chairman and CEO Oct 13, 2017 Sale $59.46 1,500 89,190 3,062 Oct 17, 2017, 05:36 PM
Geary Richard S SVP, Development Oct 13, 2017 Option Exercise $7.42 7,461 55,387 19,386 Oct 17, 2017, 05:36 PM
Geary Richard S SVP, Development Oct 13, 2017 Sale $60.00 8,268 496,080 12,351 Oct 17, 2017, 05:36 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Oct 05, 2017 Option Exercise $10.11 1,000 10,106 11,233 Oct 06, 2017, 04:41 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Oct 05, 2017 Sale $55.00 1,000 55,000 10,433 Oct 06, 2017, 04:41 PM
CROOKE STANLEY T Chairman and CEO Oct 02, 2017 Option Exercise $7.25 1,500 10,875 3,562 Oct 04, 2017, 07:15 PM
CROOKE STANLEY T Chairman and CEO Oct 04, 2017 Option Exercise $7.25 1,000 7,250 3,562 Oct 04, 2017, 07:15 PM
CROOKE STANLEY T Chairman and CEO Oct 02, 2017 Option Exercise $14.69 15,000 220,350 43,014 Oct 04, 2017, 07:15 PM
CROOKE STANLEY T Chairman and CEO Oct 04, 2017 Option Exercise $14.69 10,000 146,900 43,014 Oct 04, 2017, 07:15 PM
CROOKE STANLEY T Chairman and CEO Oct 02, 2017 Sale $52.00 15,000 780,000 38,014 Oct 04, 2017, 07:15 PM
CROOKE STANLEY T Chairman and CEO Oct 04, 2017 Sale $54.23 10,000 542,250 38,014 Oct 04, 2017, 07:15 PM
CROOKE STANLEY T Chairman and CEO Oct 02, 2017 Sale $52.00 1,500 78,000 3,062 Oct 04, 2017, 07:15 PM
CROOKE STANLEY T Chairman and CEO Oct 04, 2017 Sale $54.23 1,000 54,225 3,062 Oct 04, 2017, 07:15 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Sep 06, 2017 Option Exercise $7.25 800 5,800 11,233 Sep 07, 2017, 08:23 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Sep 05, 2017 Option Exercise $7.25 200 1,450 10,633 Sep 07, 2017, 08:23 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Sep 05, 2017 Sale $55.00 200 11,000 10,433 Sep 07, 2017, 08:23 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Sep 06, 2017 Sale $55.00 800 44,000 10,433 Sep 07, 2017, 08:23 PM
BENNETT C FRANK SVP, Antisense Research Jul 24, 2017 Option Exercise $10.29 10,000 102,900 25,041 Jul 26, 2017, 08:03 PM
BENNETT C FRANK SVP, Antisense Research Jul 24, 2017 Sale $59.29 10,000 592,900 15,041 Jul 26, 2017, 08:03 PM
CROOKE STANLEY T Chairman and CEO Jul 20, 2017 Option Exercise $14.69 10,000 146,900 48,014 Jul 24, 2017, 05:54 PM
CROOKE STANLEY T Chairman and CEO Jul 20, 2017 Option Exercise $7.25 1,000 7,250 4,062 Jul 24, 2017, 05:54 PM
CROOKE STANLEY T Chairman and CEO Jul 20, 2017 Sale $55.35 1,000 55,350 3,062 Jul 24, 2017, 05:54 PM
CROOKE STANLEY T Chairman and CEO Jul 20, 2017 Sale $55.35 10,000 553,500 38,014 Jul 24, 2017, 05:54 PM
CROOKE STANLEY T Chairman and CEO Jul 17, 2017 Option Exercise $14.69 15,000 220,350 53,014 Jul 18, 2017, 07:01 PM
CROOKE STANLEY T Chairman and CEO Jul 17, 2017 Option Exercise $7.25 1,500 10,875 4,562 Jul 18, 2017, 07:01 PM
CROOKE STANLEY T Chairman and CEO Jul 17, 2017 Sale $52.45 1,500 78,675 3,062 Jul 18, 2017, 07:01 PM
CROOKE STANLEY T Chairman and CEO Jul 17, 2017 Sale $52.45 15,000 786,750 38,014 Jul 18, 2017, 07:01 PM
Monia Brett P SVP, Antisense Drug Discovery Jul 01, 2017 Option Exercise $40.66 163 6,627 11,935 Jul 03, 2017, 05:38 PM
Monia Brett P SVP, Antisense Drug Discovery Jul 03, 2017 Sale $51.35 309 15,867 11,626 Jul 03, 2017, 05:38 PM
PARSHALL B LYNNE COO Jul 01, 2017 Option Exercise $40.66 90 3,659 25,741 Jul 03, 2017, 05:38 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jul 01, 2017 Option Exercise $40.66 134 5,448 10,433 Jul 03, 2017, 05:37 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jul 01, 2017 Option Exercise $40.66 104 4,228 10,392 Jul 03, 2017, 05:36 PM
Geary Richard S SVP, Development Jul 01, 2017 Option Exercise $40.66 196 7,968 13,158 Jul 03, 2017, 05:36 PM
Boyce Sarah Chief Business Officer Jul 01, 2017 Option Exercise $40.66 17 691 5,269 Jul 03, 2017, 05:35 PM
BENNETT C FRANK SVP, Antisense Research Jul 01, 2017 Option Exercise $40.66 253 10,286 15,041 Jul 03, 2017, 05:35 PM
CROOKE STANLEY T Chairman and CEO Jul 03, 2017 Option Exercise $8.01 15,000 120,193 51,476 Jul 03, 2017, 05:34 PM
CROOKE STANLEY T Chairman and CEO Jul 03, 2017 Option Exercise $7.25 1,500 10,875 4,562 Jul 03, 2017, 05:34 PM
CROOKE STANLEY T Chairman and CEO Jul 03, 2017 Sale $52.10 1,500 78,150 3,062 Jul 03, 2017, 05:34 PM
CROOKE STANLEY T Chairman and CEO Jul 03, 2017 Sale $52.10 15,000 781,538 38,014 Jul 03, 2017, 05:34 PM
MUTO FREDERICK T Director May 31, 2017 Option Exercise $9.77 12,500 122,125 17,158 Jun 02, 2017, 06:16 PM
MUTO FREDERICK T Director May 31, 2017 Sale $45.22 12,500 565,250 4,658 Jun 02, 2017, 06:16 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jun 01, 2017 Option Exercise $10.82 70 757 10,369 Jun 02, 2017, 06:15 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jun 01, 2017 Sale $48.00 70 3,360 10,299 Jun 02, 2017, 06:15 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel May 01, 2017 Option Exercise $10.82 500 5,410 10,799 May 03, 2017, 06:01 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel May 01, 2017 Sale $48.75 650 31,688 10,299 May 03, 2017, 06:01 PM
CROOKE STANLEY T Chairman and CEO Apr 25, 2017 Option Exercise $7.25 1,500 10,875 4,562 Apr 27, 2017, 06:03 PM
CROOKE STANLEY T Chairman and CEO Apr 25, 2017 Option Exercise $7.25 15,000 108,750 53,014 Apr 27, 2017, 06:03 PM
CROOKE STANLEY T Chairman and CEO Apr 25, 2017 Sale $47.81 15,000 717,150 38,014 Apr 27, 2017, 06:03 PM
CROOKE STANLEY T Chairman and CEO Apr 25, 2017 Sale $47.81 1,500 71,715 3,062 Apr 27, 2017, 06:03 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Apr 24, 2017 Option Exercise $10.82 500 5,410 10,875 Apr 26, 2017, 05:58 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Apr 24, 2017 Sale $45.00 500 22,500 10,449 Apr 26, 2017, 05:58 PM
CROOKE STANLEY T Chairman and CEO Apr 19, 2017 Option Exercise $7.25 5,000 36,250 43,014 Apr 21, 2017, 05:42 PM
CROOKE STANLEY T Chairman and CEO Apr 19, 2017 Option Exercise $7.25 500 3,625 3,562 Apr 21, 2017, 05:42 PM
CROOKE STANLEY T Chairman and CEO Apr 19, 2017 Sale $43.25 500 21,625 3,062 Apr 21, 2017, 05:42 PM
CROOKE STANLEY T Chairman and CEO Apr 19, 2017 Sale $43.25 5,000 216,250 38,014 Apr 21, 2017, 05:42 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Apr 12, 2017 Sale $40.07 1,000 40,070 10,449 Apr 13, 2017, 07:25 PM
CROOKE STANLEY T Chairman and CEO Apr 12, 2017 Option Exercise $7.25 10,000 72,500 48,014 Apr 13, 2017, 07:24 PM
CROOKE STANLEY T Chairman and CEO Apr 13, 2017 Option Exercise $7.25 10,000 72,500 48,014 Apr 13, 2017, 07:24 PM
CROOKE STANLEY T Chairman and CEO Apr 12, 2017 Option Exercise $10.29 1,000 10,290 4,062 Apr 13, 2017, 07:24 PM
CROOKE STANLEY T Chairman and CEO Apr 13, 2017 Option Exercise $8.77 1,000 8,770 3,562 Apr 13, 2017, 07:24 PM
CROOKE STANLEY T Chairman and CEO Apr 12, 2017 Sale $40.07 10,000 400,700 38,014 Apr 13, 2017, 07:24 PM
CROOKE STANLEY T Chairman and CEO Apr 13, 2017 Sale $41.30 10,000 413,000 38,014 Apr 13, 2017, 07:24 PM
CROOKE STANLEY T Chairman and CEO Apr 13, 2017 Sale $41.30 1,000 41,300 3,062 Apr 13, 2017, 07:24 PM
CROOKE STANLEY T Chairman and CEO Apr 12, 2017 Sale $40.07 1,000 40,070 3,062 Apr 13, 2017, 07:24 PM
BENNETT C FRANK SVP, Antisense Research Mar 03, 2017 Option Exercise $10.29 5,000 51,450 19,788 Mar 06, 2017, 07:25 PM
BENNETT C FRANK SVP, Antisense Research Mar 03, 2017 Sale $55.00 5,000 275,000 14,788 Mar 06, 2017, 07:25 PM
CROOKE STANLEY T Chairman and CEO Mar 02, 2017 Option Exercise $10.29 1,100 11,319 4,162 Mar 06, 2017, 07:23 PM
CROOKE STANLEY T Chairman and CEO Mar 02, 2017 Option Exercise $7.25 11,000 79,750 49,014 Mar 06, 2017, 07:23 PM
CROOKE STANLEY T Chairman and CEO Mar 02, 2017 Sale $51.05 1,100 56,155 3,062 Mar 06, 2017, 07:23 PM
CROOKE STANLEY T Chairman and CEO Mar 02, 2017 Sale $51.05 11,000 561,550 38,014 Mar 06, 2017, 07:23 PM
PARSHALL B LYNNE COO Mar 01, 2017 Option Exercise $14.69 4,625 67,941 30,276 Mar 02, 2017, 07:12 PM
PARSHALL B LYNNE COO Mar 01, 2017 Sale $49.26 4,625 227,827 25,651 Mar 02, 2017, 07:12 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 01, 2017 Option Exercise $10.82 500 5,410 12,949 Mar 02, 2017, 07:11 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 01, 2017 Sale $49.29 1,500 73,935 12,449 Mar 02, 2017, 07:11 PM
BERTHELSEN SPENCER R Director Feb 24, 2017 Option Exercise $9.77 12,500 122,125 88,958 Feb 27, 2017, 07:15 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Feb 06, 2017 Option Exercise $10.68 500 5,342 12,930 Feb 08, 2017, 06:32 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Feb 06, 2017 Sale $46.17 1,500 69,254 12,449 Feb 08, 2017, 06:32 PM
Boyce Sarah Chief Business Officer Jan 17, 2017 Sale $46.29 1,361 63,001 5,252 Jan 18, 2017, 06:48 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 17, 2017 Sale $46.29 2,502 115,819 11,772 Jan 18, 2017, 06:38 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 17, 2017 Sale $46.29 2,246 103,968 13,449 Jan 18, 2017, 06:37 PM
BENNETT C FRANK SVP, Antisense Research Jan 17, 2017 Sale $46.29 2,421 112,069 14,788 Jan 18, 2017, 06:37 PM
CROOKE STANLEY T Chairman and CEO Jan 17, 2017 Sale $46.29 15,382 712,026 38,014 Jan 18, 2017, 06:36 PM
CROOKE STANLEY T Chairman and CEO Jan 17, 2017 Sale $46.29 575 26,617 3,062 Jan 18, 2017, 06:36 PM
PARSHALL B LYNNE COO Jan 17, 2017 Sale $46.29 7,246 335,414 25,651 Jan 18, 2017, 06:36 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 17, 2017 Sale $46.29 2,273 105,218 10,288 Jan 18, 2017, 06:35 PM
Geary Richard S SVP, Development Jan 17, 2017 Sale $46.29 2,441 112,996 12,962 Jan 18, 2017, 06:35 PM
CROOKE STANLEY T Chairman and CEO Jan 10, 2017 Option Exercise $10.29 1,200 12,348 3,370 Jan 12, 2017, 06:18 PM
CROOKE STANLEY T Chairman and CEO Jan 10, 2017 Option Exercise $7.25 12,000 87,000 37,029 Jan 12, 2017, 06:18 PM
CROOKE STANLEY T Chairman and CEO Jan 10, 2017 Sale $49.25 1,200 59,100 2,170 Jan 12, 2017, 06:18 PM
CROOKE STANLEY T Chairman and CEO Jan 10, 2017 Sale $49.25 12,000 591,000 25,029 Jan 12, 2017, 06:18 PM
CROOKE STANLEY T Chairman and CEO Jan 03, 2017 Option Exercise $7.25 10,000 72,500 30,029 Jan 04, 2017, 06:35 PM
CROOKE STANLEY T Chairman and CEO Jan 04, 2017 Option Exercise $7.25 7,000 50,750 32,029 Jan 04, 2017, 06:35 PM
CROOKE STANLEY T Chairman and CEO Jan 03, 2017 Option Exercise $10.29 1,000 10,290 2,670 Jan 04, 2017, 06:35 PM
CROOKE STANLEY T Chairman and CEO Jan 04, 2017 Option Exercise $10.29 700 7,203 2,870 Jan 04, 2017, 06:35 PM
CROOKE STANLEY T Chairman and CEO Jan 03, 2017 Sale $48.05 10,000 480,500 25,029 Jan 04, 2017, 06:35 PM
CROOKE STANLEY T Chairman and CEO Jan 04, 2017 Sale $50.10 7,000 350,700 25,029 Jan 04, 2017, 06:35 PM
CROOKE STANLEY T Chairman and CEO Jan 03, 2017 Sale $48.05 1,000 48,050 2,170 Jan 04, 2017, 06:35 PM
CROOKE STANLEY T Chairman and CEO Jan 04, 2017 Sale $50.10 700 35,070 2,170 Jan 04, 2017, 06:35 PM
Boyce Sarah Chief Business Officer Jan 01, 2017 Option Exercise $20.76 992 20,591 3,130 Jan 04, 2017, 06:35 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 01, 2017 Option Exercise $20.76 309 6,414 8,181 Jan 04, 2017, 06:34 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 03, 2017 Sale $48.60 309 15,017 7,872 Jan 04, 2017, 06:34 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 01, 2017 Option Exercise $20.76 424 8,801 9,950 Jan 04, 2017, 06:34 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 01, 2017 Option Exercise $20.76 199 4,131 6,747 Jan 04, 2017, 06:33 PM
BENNETT C FRANK SVP, Antisense Research Jan 01, 2017 Option Exercise $20.76 211 4,380 11,014 Jan 04, 2017, 06:32 PM
PARSHALL B LYNNE COO Jan 01, 2017 Option Exercise $20.76 171 3,549 16,864 Jan 04, 2017, 06:31 PM
Geary Richard S SVP, Development Jan 01, 2017 Option Exercise $20.76 640 13,284 9,157 Jan 04, 2017, 06:30 PM
Monia Brett P SVP, Antisense Drug Discovery Dec 20, 2016 Sale $52.48 130 6,822 7,872 Dec 20, 2016, 06:48 PM
PARSHALL B LYNNE COO Dec 15, 2016 Option Exercise $7.25 1,000 7,250 1,000 Dec 16, 2016, 07:21 PM
PARSHALL B LYNNE COO Dec 15, 2016 Option Exercise $7.25 2,000 14,500 1,000 Dec 16, 2016, 07:21 PM
PARSHALL B LYNNE COO Dec 15, 2016 Option Exercise $7.25 1,000 7,250 1,000 Dec 16, 2016, 07:21 PM
PARSHALL B LYNNE COO Dec 15, 2016 Sale $50.00 2,000 100,000 0 Dec 16, 2016, 07:21 PM
PARSHALL B LYNNE COO Dec 15, 2016 Sale $50.00 1,000 50,000 0 Dec 16, 2016, 07:21 PM
PARSHALL B LYNNE COO Dec 15, 2016 Sale $50.00 1,000 50,000 0 Dec 16, 2016, 07:21 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 05, 2016 Option Exercise $11.27 2,500 28,175 9,048 Dec 07, 2016, 07:51 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Dec 05, 2016 Sale $46.05 2,500 115,125 6,548 Dec 07, 2016, 07:51 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Dec 05, 2016 Option Exercise $10.82 350 3,787 9,876 Dec 07, 2016, 07:27 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Dec 05, 2016 Sale $45.00 350 15,750 9,526 Dec 07, 2016, 07:27 PM
PARSHALL B LYNNE COO Dec 01, 2016 Option Exercise $14.69 12,500 183,625 23,693 Dec 02, 2016, 06:58 PM
PARSHALL B LYNNE COO Dec 01, 2016 Sale $42.23 12,500 527,865 16,693 Dec 02, 2016, 06:58 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Nov 14, 2016 Option Exercise $10.82 1,000 10,820 10,332 Nov 14, 2016, 06:53 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Nov 14, 2016 Sale $45.00 1,000 45,000 9,526 Nov 14, 2016, 06:53 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 11, 2016 Option Exercise $11.27 2,500 28,175 9,048 Nov 14, 2016, 06:52 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 09, 2016 Option Exercise $11.27 2,500 28,175 9,048 Nov 14, 2016, 06:52 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 09, 2016 Sale $38.49 2,500 96,225 6,548 Nov 14, 2016, 06:52 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Nov 11, 2016 Sale $41.00 2,500 102,500 6,548 Nov 14, 2016, 06:52 PM
CROOKE STANLEY T Chairman and CEO Nov 10, 2016 Option Exercise $10.29 1,000 10,290 3,170 Nov 14, 2016, 06:51 PM
CROOKE STANLEY T Chairman and CEO Nov 09, 2016 Option Exercise $10.29 2,000 20,580 3,170 Nov 14, 2016, 06:51 PM
CROOKE STANLEY T Chairman and CEO Nov 09, 2016 Option Exercise $9.72 20,000 194,427 35,029 Nov 14, 2016, 06:51 PM
CROOKE STANLEY T Chairman and CEO Nov 10, 2016 Option Exercise $7.25 10,000 72,500 35,029 Nov 14, 2016, 06:51 PM
CROOKE STANLEY T Chairman and CEO Nov 10, 2016 Sale $40.23 10,000 402,300 25,029 Nov 14, 2016, 06:51 PM
CROOKE STANLEY T Chairman and CEO Nov 09, 2016 Sale $36.40 20,000 727,996 25,029 Nov 14, 2016, 06:51 PM
CROOKE STANLEY T Chairman and CEO Nov 10, 2016 Sale $42.22 1,000 42,220 2,170 Nov 14, 2016, 06:51 PM
CROOKE STANLEY T Chairman and CEO Nov 09, 2016 Sale $36.17 2,000 72,350 2,170 Nov 14, 2016, 06:51 PM
BENNETT C FRANK SVP, Antisense Research Nov 09, 2016 Option Exercise $11.27 22,805 257,012 28,608 Nov 14, 2016, 06:51 PM
BENNETT C FRANK SVP, Antisense Research Nov 09, 2016 Sale $37.56 22,805 856,605 10,803 Nov 14, 2016, 06:51 PM
BENNETT C FRANK SVP, Antisense Research Nov 07, 2016 Option Exercise $11.27 5,000 56,350 15,803 Nov 09, 2016, 06:22 PM
BENNETT C FRANK SVP, Antisense Research Nov 07, 2016 Sale $34.00 5,000 170,000 10,803 Nov 09, 2016, 06:22 PM
CROOKE STANLEY T Chairman and CEO Oct 05, 2016 Option Exercise $10.29 1,000 10,290 3,170 Oct 07, 2016, 05:49 PM
CROOKE STANLEY T Chairman and CEO Oct 05, 2016 Option Exercise $10.29 10,000 102,900 35,029 Oct 07, 2016, 05:49 PM
CROOKE STANLEY T Chairman and CEO Oct 05, 2016 Sale $36.61 10,000 366,100 25,029 Oct 07, 2016, 05:49 PM
CROOKE STANLEY T Chairman and CEO Oct 05, 2016 Sale $36.61 1,000 36,610 2,170 Oct 07, 2016, 05:49 PM
CROOKE STANLEY T Chairman and CEO Sep 27, 2016 Option Exercise $10.29 2,000 20,580 4,170 Sep 29, 2016, 05:05 PM
CROOKE STANLEY T Chairman and CEO Sep 27, 2016 Option Exercise $10.29 20,000 205,800 45,029 Sep 29, 2016, 05:05 PM
CROOKE STANLEY T Chairman and CEO Sep 27, 2016 Sale $36.02 20,000 720,400 25,029 Sep 29, 2016, 05:05 PM
CROOKE STANLEY T Chairman and CEO Sep 27, 2016 Sale $36.05 2,000 72,100 2,170 Sep 29, 2016, 05:05 PM
CROOKE STANLEY T Chairman and CEO Sep 21, 2016 Option Exercise $10.29 2,000 20,580 4,170 Sep 23, 2016, 06:31 PM
CROOKE STANLEY T Chairman and CEO Sep 21, 2016 Option Exercise $10.29 20,000 205,800 45,029 Sep 23, 2016, 06:31 PM
CROOKE STANLEY T Chairman and CEO Sep 21, 2016 Sale $35.50 20,000 710,000 25,029 Sep 23, 2016, 06:31 PM
CROOKE STANLEY T Chairman and CEO Sep 21, 2016 Sale $35.50 2,000 71,000 2,170 Sep 23, 2016, 06:31 PM
PARSHALL B LYNNE COO Sep 01, 2016 Option Exercise $9.41 12,500 117,669 25,558 Sep 06, 2016, 06:52 PM
PARSHALL B LYNNE COO Sep 01, 2016 Sale $29.88 12,500 373,545 16,693 Sep 06, 2016, 06:52 PM
PARSHALL B LYNNE COO Jul 01, 2016 Option Exercise $20.76 403 8,365 16,693 Jul 01, 2016, 08:22 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jul 01, 2016 Option Exercise $20.76 402 8,344 9,526 Jul 01, 2016, 08:21 PM
Monia Brett P SVP, Antisense Drug Discovery Jul 01, 2016 Option Exercise $20.76 309 6,414 8,002 Jul 01, 2016, 08:20 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jul 01, 2016 Option Exercise $20.76 217 4,504 6,548 Jul 01, 2016, 08:20 PM
Geary Richard S SVP, Development Jul 01, 2016 Option Exercise $20.76 163 3,383 8,517 Jul 01, 2016, 08:19 PM
Boyce Sarah Chief Business Officer Jul 01, 2016 Option Exercise $20.76 403 8,365 2,138 Jul 01, 2016, 08:18 PM
BENNETT C FRANK SVP, Antisense Research Jul 01, 2016 Option Exercise $20.76 213 4,421 10,803 Jul 01, 2016, 08:18 PM
MUTO FREDERICK T Director May 31, 2016 Option Exercise $5.93 12,500 74,125 15,043 Jun 02, 2016, 06:25 PM
MUTO FREDERICK T Director May 31, 2016 Sale $22.31 12,500 278,900 2,543 Jun 02, 2016, 06:25 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Apr 06, 2016 Option Exercise $10.82 1,000 10,820 10,124 Apr 07, 2016, 06:18 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Apr 06, 2016 Sale $45.00 1,000 45,000 9,124 Apr 07, 2016, 06:18 PM
CROOKE STANLEY T Chairman and CEO Apr 06, 2016 Option Exercise $10.29 10,000 102,900 30,029 Apr 07, 2016, 06:18 PM
CROOKE STANLEY T Chairman and CEO Apr 06, 2016 Option Exercise $10.29 1,000 10,290 2,670 Apr 07, 2016, 06:18 PM
CROOKE STANLEY T Chairman and CEO Apr 06, 2016 Sale $46.13 10,000 461,250 25,029 Apr 07, 2016, 06:18 PM
CROOKE STANLEY T Chairman and CEO Apr 06, 2016 Sale $46.13 1,000 46,125 2,170 Apr 07, 2016, 06:18 PM
CROOKE STANLEY T Chairman and CEO Mar 31, 2016 Option Exercise $9.76 1,000 9,755 2,670 Apr 01, 2016, 06:18 PM
CROOKE STANLEY T Chairman and CEO Mar 31, 2016 Option Exercise $10.29 10,000 102,900 30,029 Apr 01, 2016, 06:18 PM
CROOKE STANLEY T Chairman and CEO Mar 31, 2016 Sale $40.74 1,000 40,735 2,170 Apr 01, 2016, 06:18 PM
CROOKE STANLEY T Chairman and CEO Mar 31, 2016 Sale $40.74 10,000 407,350 25,029 Apr 01, 2016, 06:18 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 23, 2016 Option Exercise $10.82 1,000 10,820 10,124 Mar 24, 2016, 07:13 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 23, 2016 Sale $45.40 1,000 45,400 9,124 Mar 24, 2016, 07:13 PM
BERTHELSEN SPENCER R Director Feb 19, 2016 Option Exercise $5.93 12,500 74,125 74,343 Feb 22, 2016, 04:10 PM
CROOKE STANLEY T Chairman and CEO Jan 19, 2016 Sale $41.46 12,825 531,716 25,029 Jan 19, 2016, 08:27 PM
CROOKE STANLEY T Chairman and CEO Jan 19, 2016 Sale $41.46 576 23,882 2,170 Jan 19, 2016, 08:27 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 19, 2016 Sale $41.46 1,899 78,742 6,331 Jan 19, 2016, 08:27 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 19, 2016 Sale $41.46 1,871 77,574 9,124 Jan 19, 2016, 08:12 PM
PARSHALL B LYNNE COO & Secretary Jan 19, 2016 Sale $41.46 5,192 215,257 16,290 Jan 19, 2016, 08:11 PM
Geary Richard S SVP, Development Jan 19, 2016 Sale $41.46 2,162 89,634 8,354 Jan 19, 2016, 08:09 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 19, 2016 Sale $41.46 2,208 91,541 7,693 Jan 19, 2016, 08:09 PM
Boyce Sarah Chief Business Officer Jan 19, 2016 Sale $41.46 872 36,151 1,735 Jan 19, 2016, 08:08 PM
BENNETT C FRANK SVP, Antisense Research Jan 19, 2016 Sale $41.46 2,110 87,474 10,590 Jan 19, 2016, 08:08 PM
CROOKE STANLEY T Chairman and CEO Jan 05, 2016 Option Exercise $9.22 500 4,610 1,797 Jan 07, 2016, 06:52 PM
CROOKE STANLEY T Chairman and CEO Jan 05, 2016 Option Exercise $10.29 5,000 51,450 19,642 Jan 07, 2016, 06:52 PM
CROOKE STANLEY T Chairman and CEO Jan 05, 2016 Sale $62.10 500 31,050 1,297 Jan 07, 2016, 06:52 PM
CROOKE STANLEY T Chairman and CEO Jan 05, 2016 Sale $62.10 5,000 310,500 14,642 Jan 07, 2016, 06:52 PM
PARSHALL B LYNNE COO & Secretary Jan 01, 2016 Option Exercise $47.71 72 3,435 8,215 Jan 04, 2016, 09:26 PM
PARSHALL B LYNNE COO & Secretary Jan 04, 2016 Option Exercise $14.69 809 11,884 9,024 Jan 04, 2016, 09:26 PM
PARSHALL B LYNNE COO & Secretary Jan 04, 2016 Sale $61.05 809 49,389 8,215 Jan 04, 2016, 09:26 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 01, 2016 Option Exercise $47.71 43 2,052 6,302 Jan 04, 2016, 09:25 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 04, 2016 Option Exercise $7.79 1,000 7,793 7,150 Jan 04, 2016, 09:25 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 04, 2016 Sale $61.10 1,000 61,100 6,302 Jan 04, 2016, 09:25 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 01, 2016 Option Exercise $47.71 130 6,202 4,485 Jan 04, 2016, 09:24 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 04, 2016 Sale $61.00 127 7,747 4,358 Jan 04, 2016, 09:24 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 01, 2016 Option Exercise $47.71 41 1,956 3,468 Jan 04, 2016, 09:23 PM
Geary Richard S SVP, Development Jan 01, 2016 Option Exercise $47.71 269 12,834 5,089 Jan 04, 2016, 09:23 PM
CROOKE STANLEY T Chairman and CEO Jan 04, 2016 Option Exercise $9.22 1,000 9,220 2,297 Jan 04, 2016, 09:22 PM
CROOKE STANLEY T Chairman and CEO Jan 04, 2016 Option Exercise $10.29 10,000 102,900 24,642 Jan 04, 2016, 09:22 PM
CROOKE STANLEY T Chairman and CEO Jan 04, 2016 Sale $61.05 10,000 610,500 14,642 Jan 04, 2016, 09:22 PM
CROOKE STANLEY T Chairman and CEO Jan 04, 2016 Sale $61.05 1,000 61,050 1,297 Jan 04, 2016, 09:22 PM
Boyce Sarah Chief Business Officer Jan 01, 2016 Option Exercise $47.71 419 19,991 419 Jan 04, 2016, 09:21 PM
BENNETT C FRANK SVP, Antisense Research Jan 01, 2016 Option Exercise $47.71 89 4,246 7,405 Jan 04, 2016, 09:19 PM
BENNETT C FRANK SVP, Antisense Research Dec 15, 2015 Option Exercise $14.47 4,000 57,880 11,316 Dec 17, 2015, 07:23 PM
BENNETT C FRANK SVP, Antisense Research Dec 16, 2015 Option Exercise $14.47 3,909 56,563 11,225 Dec 17, 2015, 07:23 PM
BENNETT C FRANK SVP, Antisense Research Dec 16, 2015 Sale $58.85 3,909 230,045 7,316 Dec 17, 2015, 07:23 PM
BENNETT C FRANK SVP, Antisense Research Dec 15, 2015 Sale $56.00 4,000 224,000 7,316 Dec 17, 2015, 07:23 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Dec 01, 2015 Option Exercise $7.25 1,000 7,250 7,259 Dec 02, 2015, 06:49 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Dec 01, 2015 Sale $61.50 1,000 61,500 6,259 Dec 02, 2015, 06:49 PM
BENNETT C FRANK SVP, Antisense Research Nov 10, 2015 Option Exercise $14.47 5,000 72,350 12,316 Nov 12, 2015, 07:03 PM
BENNETT C FRANK SVP, Antisense Research Nov 10, 2015 Sale $64.00 5,000 320,000 7,316 Nov 12, 2015, 07:03 PM
KLEIN JOSEPH III Director Nov 11, 2015 Option Exercise $10.95 6,875 75,312 9,293 Nov 12, 2015, 07:02 PM
KLEIN JOSEPH III Director Nov 11, 2015 Sale $64.18 6,875 441,234 5,543 Nov 12, 2015, 07:02 PM
BENNETT C FRANK SVP, Antisense Research Nov 06, 2015 Option Exercise $14.47 5,000 72,350 12,316 Nov 09, 2015, 07:28 PM
BENNETT C FRANK SVP, Antisense Research Nov 06, 2015 Sale $56.00 5,000 280,000 7,316 Nov 09, 2015, 07:28 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Nov 03, 2015 Option Exercise $7.25 1,000 7,250 7,259 Nov 04, 2015, 07:00 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Nov 03, 2015 Sale $51.95 1,000 51,950 6,259 Nov 04, 2015, 07:00 PM
CROOKE STANLEY T Chairman and CEO Oct 21, 2015 Option Exercise $10.59 1,500 15,880 2,297 Oct 23, 2015, 07:35 PM
CROOKE STANLEY T Chairman and CEO Oct 23, 2015 Option Exercise $9.22 2,500 23,050 3,297 Oct 23, 2015, 07:35 PM
CROOKE STANLEY T Chairman and CEO Oct 21, 2015 Option Exercise $11.27 15,000 169,050 29,642 Oct 23, 2015, 07:35 PM
CROOKE STANLEY T Chairman and CEO Oct 23, 2015 Option Exercise $10.45 25,000 261,330 30,479 Oct 23, 2015, 07:35 PM
CROOKE STANLEY T Chairman and CEO Oct 21, 2015 Sale $43.00 15,000 645,000 14,642 Oct 23, 2015, 07:35 PM
CROOKE STANLEY T Chairman and CEO Oct 23, 2015 Sale $44.35 25,000 1,108,855 14,642 Oct 23, 2015, 07:35 PM
CROOKE STANLEY T Chairman and CEO Oct 21, 2015 Sale $43.00 1,500 64,500 1,297 Oct 23, 2015, 07:35 PM
CROOKE STANLEY T Chairman and CEO Oct 23, 2015 Sale $44.40 2,500 111,000 1,297 Oct 23, 2015, 07:35 PM
PARSHALL B LYNNE COO & Secretary Oct 02, 2015 Option Exercise $14.69 5,436 79,855 11,579 Oct 05, 2015, 07:14 PM
PARSHALL B LYNNE COO & Secretary Oct 01, 2015 Option Exercise $10.27 7,000 71,865 12,305 Oct 05, 2015, 07:14 PM
PARSHALL B LYNNE COO & Secretary Oct 02, 2015 Sale $41.55 5,436 225,867 8,143 Oct 05, 2015, 07:14 PM
PARSHALL B LYNNE COO & Secretary Oct 01, 2015 Sale $40.13 7,000 280,880 8,143 Oct 05, 2015, 07:14 PM
PARSHALL B LYNNE COO & Secretary Jul 06, 2015 Option Exercise $7.92 6,218 49,260 12,986 Jul 08, 2015, 05:55 PM
PARSHALL B LYNNE COO & Secretary Jul 06, 2015 Sale $57.01 6,218 354,470 8,143 Jul 08, 2015, 05:55 PM
CROOKE STANLEY T Chairman and CEO Jul 06, 2015 Option Exercise $9.22 1,175 10,834 2,472 Jul 08, 2015, 05:54 PM
CROOKE STANLEY T Chairman and CEO Jul 06, 2015 Option Exercise $11.27 5,000 56,350 19,642 Jul 08, 2015, 05:54 PM
CROOKE STANLEY T Chairman and CEO Jul 06, 2015 Sale $57.01 5,000 285,035 14,642 Jul 08, 2015, 05:54 PM
CROOKE STANLEY T Chairman and CEO Jul 06, 2015 Sale $57.01 1,175 66,983 1,297 Jul 08, 2015, 05:54 PM
PARSHALL B LYNNE COO & Secretary Jul 01, 2015 Option Exercise $48.59 71 3,450 8,143 Jul 02, 2015, 06:06 PM
PARSHALL B LYNNE COO & Secretary Jul 01, 2015 Option Exercise $10.29 6,218 63,983 14,361 Jul 02, 2015, 06:06 PM
PARSHALL B LYNNE COO & Secretary Jul 01, 2015 Sale $57.56 6,218 357,914 8,143 Jul 02, 2015, 06:06 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jul 01, 2015 Option Exercise $48.59 85 4,130 6,259 Jul 02, 2015, 06:05 PM
Monia Brett P SVP, Antisense Drug Discovery Jul 01, 2015 Option Exercise $48.59 127 6,170 4,553 Jul 02, 2015, 06:05 PM
Monia Brett P SVP, Antisense Drug Discovery Jul 02, 2015 Sale $56.30 198 11,147 4,355 Jul 02, 2015, 06:05 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jul 01, 2015 Option Exercise $48.59 40 1,943 3,427 Jul 02, 2015, 06:04 PM
Geary Richard S SVP, Development Jul 01, 2015 Option Exercise $48.59 265 12,875 4,820 Jul 02, 2015, 06:03 PM
CROOKE STANLEY T Chairman and CEO Jul 01, 2015 Option Exercise $9.22 1,175 10,834 2,472 Jul 02, 2015, 06:02 PM
CROOKE STANLEY T Chairman and CEO Jul 01, 2015 Option Exercise $11.27 5,000 56,350 19,642 Jul 02, 2015, 06:02 PM
CROOKE STANLEY T Chairman and CEO Jul 01, 2015 Sale $57.56 5,000 287,805 14,642 Jul 02, 2015, 06:02 PM
CROOKE STANLEY T Chairman and CEO Jul 01, 2015 Sale $57.56 1,175 67,634 1,297 Jul 02, 2015, 06:02 PM
BENNETT C FRANK SVP, Antisense Research Jul 01, 2015 Option Exercise $48.59 87 4,227 7,316 Jul 02, 2015, 06:01 PM
Monia Brett P SVP, Antisense Drug Discovery Jun 08, 2015 Option Exercise $10.29 7,600 78,204 12,026 Jun 10, 2015, 06:36 PM
Monia Brett P SVP, Antisense Drug Discovery Jun 08, 2015 Sale $66.22 7,600 503,280 4,426 Jun 10, 2015, 06:36 PM
MUTO FREDERICK T Director Jun 01, 2015 Option Exercise $3.95 10,000 39,500 11,095 Jun 03, 2015, 05:29 PM
MUTO FREDERICK T Director Jun 01, 2015 Sale $66.91 10,000 669,110 1,095 Jun 03, 2015, 05:29 PM
BERTHELSEN SPENCER R Director Apr 17, 2015 Option Exercise $3.95 10,000 39,500 60,395 Apr 17, 2015, 06:13 PM
PARSHALL B LYNNE COO & Secretary Apr 07, 2015 Option Exercise $14.69 5,565 81,750 13,637 Apr 08, 2015, 05:12 PM
PARSHALL B LYNNE COO & Secretary Apr 07, 2015 Sale $63.07 5,565 350,990 8,072 Apr 08, 2015, 05:12 PM
CROOKE STANLEY T Chairman and CEO Apr 07, 2015 Option Exercise $9.22 2,034 18,753 3,331 Apr 08, 2015, 05:11 PM
CROOKE STANLEY T Chairman and CEO Apr 07, 2015 Option Exercise $11.27 20,343 229,266 34,985 Apr 08, 2015, 05:11 PM
CROOKE STANLEY T Chairman and CEO Apr 07, 2015 Sale $63.07 20,343 1,283,053 14,642 Apr 08, 2015, 05:11 PM
CROOKE STANLEY T Chairman and CEO Apr 07, 2015 Sale $63.07 2,034 128,286 1,297 Apr 08, 2015, 05:11 PM
PARSHALL B LYNNE COO & Secretary Apr 01, 2015 Option Exercise $14.69 5,377 78,988 13,449 Apr 06, 2015, 11:51 AM
PARSHALL B LYNNE COO & Secretary Apr 01, 2015 Sale $61.93 5,377 333,009 8,072 Apr 06, 2015, 11:51 AM
CROOKE STANLEY T Chairman and CEO Apr 01, 2015 Option Exercise $11.27 19,657 221,534 34,299 Apr 06, 2015, 11:50 AM
CROOKE STANLEY T Chairman and CEO Apr 01, 2015 Option Exercise $9.22 1,966 18,127 3,263 Apr 06, 2015, 11:50 AM
CROOKE STANLEY T Chairman and CEO Apr 01, 2015 Sale $61.93 1,966 121,759 1,297 Apr 06, 2015, 11:50 AM
CROOKE STANLEY T Chairman and CEO Apr 01, 2015 Sale $61.93 19,657 1,217,399 14,642 Apr 06, 2015, 11:50 AM
BENNETT C FRANK SVP, Antisense Research Mar 23, 2015 Option Exercise $14.47 6,000 86,820 12,229 Mar 25, 2015, 04:23 PM
BENNETT C FRANK SVP, Antisense Research Mar 24, 2015 Option Exercise $14.47 9,000 130,230 16,229 Mar 25, 2015, 04:23 PM
BENNETT C FRANK SVP, Antisense Research Mar 24, 2015 Sale $71.01 9,000 639,090 7,229 Mar 25, 2015, 04:23 PM
BENNETT C FRANK SVP, Antisense Research Mar 23, 2015 Sale $70.00 6,000 420,020 7,229 Mar 25, 2015, 04:23 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Mar 19, 2015 Option Exercise $11.27 10,000 112,700 13,387 Mar 20, 2015, 06:58 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Mar 19, 2015 Sale $73.33 10,000 733,260 3,387 Mar 20, 2015, 06:58 PM
WENDER JOSEPH H Director Mar 18, 2015 Option Exercise $5.93 12,500 74,125 36,617 Mar 20, 2015, 06:57 PM
WENDER JOSEPH H Director Mar 18, 2015 Sale $71.41 12,500 892,586 30,217 Mar 20, 2015, 06:57 PM
Geary Richard S SVP, Development Mar 19, 2015 Option Exercise $14.69 8,000 117,520 12,555 Mar 20, 2015, 06:56 PM
Geary Richard S SVP, Development Mar 19, 2015 Sale $75.00 8,000 600,032 4,555 Mar 20, 2015, 06:56 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 19, 2015 Option Exercise $22.62 30,525 690,416 16,699 Mar 20, 2015, 06:55 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 19, 2015 Sale $74.85 30,525 2,284,757 6,174 Mar 20, 2015, 06:55 PM
Geary Richard S SVP, Development Mar 05, 2015 Option Exercise $8.88 15,080 133,972 12,555 Mar 09, 2015, 07:45 PM
Geary Richard S SVP, Development Mar 05, 2015 Sale $71.15 18,095 1,287,382 4,555 Mar 09, 2015, 07:45 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Mar 05, 2015 Option Exercise $10.50 28,094 295,065 16,044 Mar 09, 2015, 07:27 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Mar 05, 2015 Sale $71.57 28,094 2,010,823 3,387 Mar 09, 2015, 07:27 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 05, 2015 Option Exercise $9.63 5,800 55,865 10,307 Mar 09, 2015, 07:27 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 05, 2015 Sale $71.67 5,800 415,674 6,174 Mar 09, 2015, 07:27 PM
WENDER JOSEPH H Director Mar 05, 2015 Option Exercise $9.77 12,500 122,125 42,717 Mar 09, 2015, 07:26 PM
WENDER JOSEPH H Director Mar 05, 2015 Sale $71.61 12,500 895,174 30,217 Mar 09, 2015, 07:26 PM
KLEIN JOSEPH III Director Mar 05, 2015 Option Exercise $10.18 10,000 101,800 11,095 Mar 09, 2015, 07:25 PM
KLEIN JOSEPH III Director Mar 05, 2015 Sale $70.95 7,000 496,681 4,095 Mar 09, 2015, 07:25 PM
WENDER JOSEPH H Director Mar 02, 2015 Sale $65.97 7,000 461,785 30,217 Mar 04, 2015, 07:15 PM
WENDER JOSEPH H Director Feb 12, 2015 Option Exercise $3.95 10,000 39,500 47,217 Feb 17, 2015, 05:39 PM
WENDER JOSEPH H Director Feb 12, 2015 Sale $62.15 10,000 621,460 37,217 Feb 17, 2015, 05:39 PM
CROOKE STANLEY T Chairman and CEO Jan 27, 2015 Option Exercise $11.27 10,000 112,700 24,642 Jan 29, 2015, 07:03 PM
CROOKE STANLEY T Chairman and CEO Jan 27, 2015 Option Exercise $9.22 1,000 9,220 2,297 Jan 29, 2015, 07:03 PM
CROOKE STANLEY T Chairman and CEO Jan 27, 2015 Sale $72.93 1,000 72,926 1,297 Jan 29, 2015, 07:03 PM
CROOKE STANLEY T Chairman and CEO Jan 27, 2015 Sale $72.93 10,000 729,260 14,642 Jan 29, 2015, 07:03 PM
CROOKE STANLEY T Chairman and CEO Jan 16, 2015 Sale $67.96 417 28,341 1,297 Jan 20, 2015, 08:00 PM
CROOKE STANLEY T Chairman and CEO Jan 16, 2015 Sale $67.96 8,637 587,007 14,642 Jan 20, 2015, 08:00 PM
PARSHALL B LYNNE COO & Secretary Jan 16, 2015 Sale $67.96 4,093 278,177 8,072 Jan 20, 2015, 07:58 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 16, 2015 Sale $67.96 1,534 104,257 4,426 Jan 20, 2015, 07:57 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 16, 2015 Sale $67.96 1,291 87,742 3,387 Jan 20, 2015, 07:57 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 16, 2015 Sale $67.96 1,291 87,742 6,174 Jan 20, 2015, 07:56 PM
BENNETT C FRANK SVP, Antisense Research Jan 16, 2015 Sale $67.96 1,518 103,169 7,229 Jan 20, 2015, 07:55 PM
Geary Richard S SVP, Development Jan 16, 2015 Sale $67.96 1,543 104,868 7,570 Jan 20, 2015, 07:53 PM
CROOKE STANLEY T Chairman and CEO Jan 09, 2015 Option Exercise $9.22 1,000 9,220 1,627 Jan 13, 2015, 06:51 PM
CROOKE STANLEY T Chairman and CEO Jan 09, 2015 Option Exercise $11.27 10,000 112,700 16,941 Jan 13, 2015, 06:51 PM
CROOKE STANLEY T Chairman and CEO Jan 09, 2015 Sale $73.57 1,000 73,570 627 Jan 13, 2015, 06:51 PM
CROOKE STANLEY T Chairman and CEO Jan 09, 2015 Sale $73.57 10,000 735,700 6,941 Jan 13, 2015, 06:51 PM
Geary Richard S SVP, Development Jan 12, 2015 Sale $73.10 597 43,641 5,064 Jan 13, 2015, 06:49 PM
CROOKE STANLEY T Chairman and CEO Jan 06, 2015 Option Exercise $11.27 10,000 112,700 16,941 Jan 08, 2015, 07:15 PM
CROOKE STANLEY T Chairman and CEO Jan 07, 2015 Option Exercise $11.27 10,000 112,700 16,941 Jan 08, 2015, 07:15 PM
CROOKE STANLEY T Chairman and CEO Jan 06, 2015 Option Exercise $9.22 1,000 9,220 1,627 Jan 08, 2015, 07:15 PM
CROOKE STANLEY T Chairman and CEO Jan 07, 2015 Option Exercise $9.22 1,000 9,220 1,627 Jan 08, 2015, 07:15 PM
CROOKE STANLEY T Chairman and CEO Jan 06, 2015 Sale $66.04 1,000 66,038 627 Jan 08, 2015, 07:15 PM
CROOKE STANLEY T Chairman and CEO Jan 07, 2015 Sale $68.05 1,000 68,048 627 Jan 08, 2015, 07:15 PM
CROOKE STANLEY T Chairman and CEO Jan 06, 2015 Sale $66.04 10,000 660,380 6,941 Jan 08, 2015, 07:15 PM
CROOKE STANLEY T Chairman and CEO Jan 07, 2015 Sale $68.05 10,000 680,480 6,941 Jan 08, 2015, 07:15 PM
PARSHALL B LYNNE COO & Secretary Jan 01, 2015 Option Exercise $30.05 111 3,335 4,417 Jan 05, 2015, 08:04 PM
PARSHALL B LYNNE COO & Secretary Jan 02, 2015 Option Exercise $14.69 11,200 164,528 15,617 Jan 05, 2015, 08:04 PM
PARSHALL B LYNNE COO & Secretary Jan 02, 2015 Sale $62.12 11,200 695,688 4,417 Jan 05, 2015, 08:04 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 01, 2015 Option Exercise $30.05 329 9,886 4,082 Jan 05, 2015, 08:03 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 02, 2015 Option Exercise $10.15 1,500 15,220 5,299 Jan 05, 2015, 08:03 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 02, 2015 Sale $62.12 1,500 93,173 4,082 Jan 05, 2015, 08:03 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 01, 2015 Option Exercise $30.05 63 1,893 1,295 Jan 05, 2015, 08:01 PM
BENNETT C FRANK SVP, Antisense Research Jan 01, 2015 Option Exercise $30.05 136 4,086 4,763 Jan 05, 2015, 07:59 PM
Geary Richard S SVP, Development Jan 01, 2015 Option Exercise $30.05 273 8,203 5,661 Jan 05, 2015, 07:57 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 01, 2015 Option Exercise $30.05 198 5,949 2,011 Jan 05, 2015, 07:56 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 02, 2015 Sale $62.75 76 4,769 1,935 Jan 05, 2015, 07:56 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Dec 01, 2014 Option Exercise $7.25 1,500 10,875 4,253 Dec 03, 2014, 07:27 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Dec 01, 2014 Sale $51.21 1,500 76,815 3,753 Dec 03, 2014, 07:27 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Nov 03, 2014 Option Exercise $7.25 1,500 10,875 5,253 Nov 05, 2014, 06:07 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Nov 03, 2014 Sale $46.17 1,500 69,255 3,753 Nov 05, 2014, 06:07 PM
PARSHALL B LYNNE COO & Secretary Oct 30, 2014 Option Exercise $8.94 11,071 98,939 12,867 Oct 31, 2014, 06:05 PM
PARSHALL B LYNNE COO & Secretary Oct 30, 2014 Sale $45.12 11,071 499,535 4,306 Oct 31, 2014, 06:05 PM
CROOKE STANLEY T Chairman and CEO Oct 23, 2014 Option Exercise $9.22 1,600 14,752 2,227 Oct 24, 2014, 04:57 PM
CROOKE STANLEY T Chairman and CEO Oct 23, 2014 Option Exercise $12.01 13,000 156,110 16,941 Oct 24, 2014, 04:57 PM
CROOKE STANLEY T Chairman and CEO Oct 23, 2014 Sale $42.22 1,600 67,552 627 Oct 24, 2014, 04:57 PM
CROOKE STANLEY T Chairman and CEO Oct 23, 2014 Sale $42.22 13,000 548,860 6,941 Oct 24, 2014, 04:57 PM
CROOKE STANLEY T Chairman and CEO Oct 03, 2014 Option Exercise $9.22 1,000 9,220 1,627 Oct 03, 2014, 07:07 PM
CROOKE STANLEY T Chairman and CEO Oct 01, 2014 Option Exercise $10.45 2,000 20,900 1,827 Oct 03, 2014, 07:07 PM
CROOKE STANLEY T Chairman and CEO Oct 01, 2014 Option Exercise $14.47 20,000 289,400 26,941 Oct 03, 2014, 07:07 PM
CROOKE STANLEY T Chairman and CEO Oct 03, 2014 Option Exercise $14.47 13,000 188,110 19,941 Oct 03, 2014, 07:07 PM
CROOKE STANLEY T Chairman and CEO Oct 03, 2014 Sale $39.49 13,000 513,331 6,941 Oct 03, 2014, 07:07 PM
CROOKE STANLEY T Chairman and CEO Oct 01, 2014 Sale $37.91 20,000 758,220 6,941 Oct 03, 2014, 07:07 PM
CROOKE STANLEY T Chairman and CEO Oct 03, 2014 Sale $39.49 1,000 39,487 627 Oct 03, 2014, 07:07 PM
CROOKE STANLEY T Chairman and CEO Oct 01, 2014 Sale $37.91 2,000 75,822 627 Oct 03, 2014, 07:07 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Oct 01, 2014 Option Exercise $7.72 1,500 11,583 4,553 Oct 03, 2014, 07:06 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Oct 01, 2014 Sale $38.04 1,500 57,060 3,753 Oct 03, 2014, 07:06 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Sep 02, 2014 Option Exercise $10.29 1,500 15,435 4,553 Sep 04, 2014, 07:13 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Sep 02, 2014 Sale $40.44 1,500 60,660 3,753 Sep 04, 2014, 07:13 PM
PARSHALL B LYNNE COO Sep 02, 2014 Option Exercise $10.17 11,071 112,574 14,934 Sep 04, 2014, 07:13 PM
PARSHALL B LYNNE COO Sep 02, 2014 Sale $40.24 11,071 445,507 4,306 Sep 04, 2014, 07:13 PM
BENNETT C FRANK SVP, Antisense Research Aug 27, 2014 Option Exercise $15.38 5,000 76,900 6,627 Aug 28, 2014, 06:49 PM
BENNETT C FRANK SVP, Antisense Research Aug 27, 2014 Sale $40.53 5,000 202,630 4,627 Aug 28, 2014, 06:49 PM
Monia Brett P SVP, Antisense Drug Discovery Aug 26, 2014 Option Exercise $9.26 27,344 253,267 16,813 Aug 28, 2014, 06:48 PM
Monia Brett P SVP, Antisense Drug Discovery Aug 26, 2014 Sale $38.14 27,344 1,043,010 1,813 Aug 28, 2014, 06:48 PM
CROOKE STANLEY T Chairman, President and CEO Aug 13, 2014 Option Exercise $11.27 1,600 18,032 2,227 Aug 15, 2014, 06:39 PM
CROOKE STANLEY T Chairman, President and CEO Aug 13, 2014 Option Exercise $14.47 15,500 224,285 22,441 Aug 15, 2014, 06:39 PM
CROOKE STANLEY T Chairman, President and CEO Aug 13, 2014 Sale $35.45 15,500 549,537 6,941 Aug 15, 2014, 06:39 PM
CROOKE STANLEY T Chairman, President and CEO Aug 13, 2014 Sale $35.45 1,600 56,726 627 Aug 15, 2014, 06:39 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Aug 12, 2014 Option Exercise $10.29 800 8,232 4,553 Aug 12, 2014, 06:51 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Aug 11, 2014 Option Exercise $10.29 700 7,203 4,453 Aug 12, 2014, 06:51 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Aug 11, 2014 Sale $35.00 700 24,500 3,753 Aug 12, 2014, 06:51 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Aug 12, 2014 Sale $35.00 800 28,000 3,753 Aug 12, 2014, 06:51 PM
CROOKE STANLEY T Chairman, President and CEO Aug 01, 2014 Option Exercise $11.27 1,000 11,270 1,627 Aug 01, 2014, 07:44 PM
CROOKE STANLEY T Chairman, President and CEO Aug 01, 2014 Option Exercise $14.47 15,000 217,050 21,941 Aug 01, 2014, 07:44 PM
CROOKE STANLEY T Chairman, President and CEO Aug 01, 2014 Sale $30.52 15,000 457,875 6,941 Aug 01, 2014, 07:44 PM
CROOKE STANLEY T Chairman, President and CEO Aug 01, 2014 Sale $30.52 1,000 30,525 627 Aug 01, 2014, 07:44 PM
Monia Brett P SVP, Antisense Drug Discovery Jul 31, 2014 Sale $31.50 79 2,489 1,813 Aug 01, 2014, 07:16 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jul 01, 2014 Option Exercise $30.20 403 12,171 3,753 Jul 02, 2014, 04:09 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jul 01, 2014 Option Exercise $10.29 1,500 15,435 5,253 Jul 02, 2014, 04:09 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jul 01, 2014 Sale $35.33 1,500 53,000 3,753 Jul 02, 2014, 04:09 PM
CROOKE STANLEY T Chairman and CEO Jul 01, 2014 Option Exercise $11.59 2,000 23,180 2,427 Jul 02, 2014, 04:08 PM
CROOKE STANLEY T Chairman and CEO Jul 01, 2014 Option Exercise $14.47 15,500 224,285 22,441 Jul 02, 2014, 04:08 PM
CROOKE STANLEY T Chairman and CEO Jul 01, 2014 Sale $35.55 2,000 71,100 627 Jul 02, 2014, 04:08 PM
CROOKE STANLEY T Chairman and CEO Jul 01, 2014 Sale $35.58 15,500 551,459 6,941 Jul 02, 2014, 04:08 PM
Geary Richard S SVP, Development Jul 01, 2014 Option Exercise $30.20 597 18,030 5,552 Jul 02, 2014, 04:08 PM
Geary Richard S SVP, Development Jul 02, 2014 Sale $35.95 164 5,896 5,388 Jul 02, 2014, 04:08 PM
PARSHALL B LYNNE COO & Secretary Jul 01, 2014 Option Exercise $30.20 284 8,577 4,306 Jul 01, 2014, 08:19 PM
Monia Brett P SVP, Antisense Drug Discovery Jul 01, 2014 Option Exercise $30.20 76 2,295 1,892 Jul 01, 2014, 08:18 PM
BENNETT C FRANK SVP, Antisense Research Jul 01, 2014 Option Exercise $30.20 291 8,788 4,627 Jul 01, 2014, 08:17 PM
BENNETT C FRANK SVP, Antisense Research Jun 23, 2014 Option Exercise $15.38 11,200 172,256 10,536 Jun 25, 2014, 07:47 PM
BENNETT C FRANK SVP, Antisense Research Jun 23, 2014 Sale $36.78 11,200 411,910 4,336 Jun 25, 2014, 07:47 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Jun 19, 2014 Option Exercise $10.18 700 7,127 3,650 Jun 20, 2014, 04:15 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Jun 19, 2014 Sale $35.35 700 24,748 3,350 Jun 20, 2014, 04:15 PM
CROOKE STANLEY T Chairman, President and CEO Jun 19, 2014 Option Exercise $14.47 11,000 159,170 17,941 Jun 20, 2014, 04:14 PM
CROOKE STANLEY T Chairman, President and CEO Jun 19, 2014 Sale $35.10 11,000 386,111 6,941 Jun 20, 2014, 04:14 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Jun 16, 2014 Option Exercise $8.00 800 6,400 3,750 Jun 18, 2014, 07:06 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Jun 16, 2014 Sale $35.14 800 28,110 3,350 Jun 18, 2014, 07:06 PM
CROOKE STANLEY T Chairman, President and CEO Jun 10, 2014 Option Exercise $14.47 10,000 144,700 16,941 Jun 12, 2014, 06:43 PM
CROOKE STANLEY T Chairman, President and CEO Jun 10, 2014 Option Exercise $14.47 1,000 14,470 1,627 Jun 12, 2014, 06:43 PM
CROOKE STANLEY T Chairman, President and CEO Jun 10, 2014 Sale $33.46 1,000 33,455 627 Jun 12, 2014, 06:43 PM
CROOKE STANLEY T Chairman, President and CEO Jun 10, 2014 Sale $33.46 10,000 334,550 6,941 Jun 12, 2014, 06:43 PM
MUTO FREDERICK T Director Jun 02, 2014 Option Exercise $5.72 10,000 57,200 10,313 Jun 03, 2014, 07:17 PM
MUTO FREDERICK T Director Jun 02, 2014 Sale $28.59 10,000 285,900 313 Jun 03, 2014, 07:17 PM
BERTHELSEN SPENCER R Director Apr 17, 2014 Option Exercise $5.72 10,000 57,200 49,613 Apr 17, 2014, 07:43 PM
CROOKE STANLEY T Chairman, President and CEO Apr 02, 2014 Option Exercise $14.47 1,800 26,046 2,427 Apr 04, 2014, 07:24 PM
CROOKE STANLEY T Chairman, President and CEO Apr 02, 2014 Option Exercise $14.47 7,000 101,290 13,941 Apr 04, 2014, 07:24 PM
CROOKE STANLEY T Chairman, President and CEO Apr 02, 2014 Sale $43.65 1,800 78,566 627 Apr 04, 2014, 07:24 PM
CROOKE STANLEY T Chairman, President and CEO Apr 02, 2014 Sale $43.65 7,000 305,536 6,941 Apr 04, 2014, 07:24 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Apr 01, 2014 Option Exercise $8.00 1,500 12,000 3,850 Apr 03, 2014, 07:32 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Apr 01, 2014 Sale $44.40 1,500 66,600 3,350 Apr 03, 2014, 07:32 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 03, 2014 Option Exercise $10.93 1,500 16,396 4,150 Mar 05, 2014, 06:55 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Mar 03, 2014 Sale $50.00 1,500 75,000 3,350 Mar 05, 2014, 06:55 PM
WENDER JOSEPH H Director Feb 06, 2014 Option Exercise $5.72 5,300 30,316 36,435 Feb 07, 2014, 07:54 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Feb 03, 2014 Option Exercise $11.27 1,500 16,905 4,850 Feb 05, 2014, 07:30 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Feb 03, 2014 Sale $50.45 1,500 75,677 3,350 Feb 05, 2014, 07:30 PM
WENDER JOSEPH H Director Feb 03, 2014 Option Exercise $5.72 4,700 26,884 35,835 Feb 05, 2014, 07:29 PM
WENDER JOSEPH H Director Feb 03, 2014 Sale $48.78 4,700 229,278 31,135 Feb 05, 2014, 07:29 PM
PARSHALL B LYNNE COO Jan 29, 2014 Option Exercise $10.40 35,000 364,043 35,050 Jan 31, 2014, 07:34 PM
PARSHALL B LYNNE COO Jan 29, 2014 Option Exercise $7.25 5,000 36,250 5,000 Jan 31, 2014, 07:34 PM
PARSHALL B LYNNE COO Jan 29, 2014 Option Exercise $7.25 10,000 72,500 5,000 Jan 31, 2014, 07:34 PM
PARSHALL B LYNNE COO Jan 30, 2014 Option Exercise $9.07 39,510 358,298 27,657 Jan 31, 2014, 07:34 PM
PARSHALL B LYNNE COO Jan 29, 2014 Sale $48.81 10,000 488,070 0 Jan 31, 2014, 07:34 PM
PARSHALL B LYNNE COO Jan 30, 2014 Sale $50.36 39,510 1,989,882 4,022 Jan 31, 2014, 07:34 PM
PARSHALL B LYNNE COO Jan 29, 2014 Sale $48.81 35,000 1,708,245 4,022 Jan 31, 2014, 07:34 PM
PARSHALL B LYNNE COO Jan 29, 2014 Sale $48.81 5,000 244,035 0 Jan 31, 2014, 07:34 PM
KLEIN JOSEPH III Director Jan 24, 2014 Option Exercise $15.40 10,313 158,800 9,813 Jan 24, 2014, 08:26 PM
KLEIN JOSEPH III Director Jan 24, 2014 Sale $48.66 10,313 501,838 2,313 Jan 24, 2014, 08:26 PM
Geary Richard S SVP, Development Jan 22, 2014 Option Exercise $10.03 22,200 222,702 18,855 Jan 24, 2014, 08:07 PM
Geary Richard S SVP, Development Jan 22, 2014 Sale $50.05 22,200 1,111,021 4,955 Jan 24, 2014, 08:07 PM
WENDER JOSEPH H Director Jan 22, 2014 Sale $50.98 10,000 509,803 31,135 Jan 24, 2014, 08:06 PM
BENNETT C FRANK SVP, Antisense Research Jan 16, 2014 Sale $47.08 804 37,853 4,336 Jan 17, 2014, 07:41 PM
Geary Richard S SVP, Development Jan 16, 2014 Sale $47.08 829 39,030 4,955 Jan 17, 2014, 07:41 PM
HOUGEN ELIZABETH L SVP, Finance & CFO Jan 16, 2014 Sale $47.08 577 27,165 1,232 Jan 17, 2014, 07:40 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 16, 2014 Sale $47.08 821 38,653 1,816 Jan 17, 2014, 07:39 PM
PARSHALL B LYNNE COO & Secretary Jan 16, 2014 Sale $47.08 1,641 77,262 4,022 Jan 17, 2014, 07:38 PM
CROOKE STANLEY T Chairman and CEO Jan 16, 2014 Sale $47.08 3,246 152,825 6,941 Jan 17, 2014, 07:37 PM
CROOKE STANLEY T Chairman and CEO Jan 16, 2014 Sale $47.08 281 13,230 627 Jan 17, 2014, 07:37 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jan 16, 2014 Sale $47.08 577 27,166 3,350 Jan 17, 2014, 07:36 PM
CROOKE STANLEY T Chairman, President and CEO Jan 08, 2014 Option Exercise $14.47 11,000 159,170 12,661 Jan 10, 2014, 07:24 PM
CROOKE STANLEY T Chairman, President and CEO Jan 08, 2014 Option Exercise $14.47 1,500 21,705 1,674 Jan 10, 2014, 07:24 PM
CROOKE STANLEY T Chairman, President and CEO Jan 08, 2014 Sale $40.05 1,500 60,078 174 Jan 10, 2014, 07:24 PM
CROOKE STANLEY T Chairman, President and CEO Jan 08, 2014 Sale $40.05 11,000 440,572 1,661 Jan 10, 2014, 07:24 PM
Geary Richard S SVP, Development Jan 06, 2014 Option Exercise $11.27 7,400 83,398 11,010 Jan 08, 2014, 07:40 PM
Geary Richard S SVP, Development Jan 08, 2014 Option Exercise $10.29 7,600 78,204 11,210 Jan 08, 2014, 07:40 PM
Geary Richard S SVP, Development Jan 06, 2014 Sale $38.83 7,400 287,364 3,610 Jan 08, 2014, 07:40 PM
Geary Richard S SVP, Development Jan 08, 2014 Sale $42.02 7,600 319,352 3,610 Jan 08, 2014, 07:40 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 01, 2014 Option Exercise $24.20 79 1,912 848 Jan 03, 2014, 07:58 PM
Monia Brett P SVP, Antisense Drug Discovery Jan 02, 2014 Sale $39.25 362 14,210 486 Jan 03, 2014, 07:58 PM
BENNETT C FRANK SVP, Antisense Research Jan 01, 2014 Option Exercise $24.20 164 3,969 3,030 Jan 03, 2014, 07:50 PM
CROOKE STANLEY T Chairman, President and CEO Jan 02, 2014 Option Exercise $14.47 29,000 419,630 26,661 Jan 03, 2014, 07:46 PM
CROOKE STANLEY T Chairman, President and CEO Jan 02, 2014 Option Exercise $14.47 2,500 36,175 2,674 Jan 03, 2014, 07:46 PM
CROOKE STANLEY T Chairman, President and CEO Jan 02, 2014 Sale $39.25 2,500 98,132 174 Jan 03, 2014, 07:46 PM
CROOKE STANLEY T Chairman, President and CEO Jan 02, 2014 Sale $39.36 29,000 1,141,325 1,661 Jan 03, 2014, 07:46 PM
Geary Richard S SVP, Development Jan 01, 2014 Option Exercise $24.20 164 3,969 3,610 Jan 03, 2014, 07:46 PM
O'NEIL PATRICK R. SVP, Legal and General Counsel Jan 01, 2014 Option Exercise $24.20 395 9,559 2,418 Jan 03, 2014, 07:45 PM
PARSHALL B LYNNE COO Jan 01, 2014 Option Exercise $24.20 397 9,607 1,353 Jan 03, 2014, 07:44 PM
PARSHALL B LYNNE COO Dec 26, 2013 Option Exercise $11.27 37,811 426,130 38,767 Dec 30, 2013, 06:29 PM
PARSHALL B LYNNE COO Dec 26, 2013 Sale $40.91 37,811 1,546,772 956 Dec 30, 2013, 06:29 PM
PARSHALL B LYNNE COO & Secretary Dec 23, 2013 Option Exercise $14.36 50,000 717,833 49,185 Dec 24, 2013, 03:21 PM
PARSHALL B LYNNE COO & Secretary Dec 24, 2013 Option Exercise $11.27 20,000 225,400 20,956 Dec 24, 2013, 03:21 PM
PARSHALL B LYNNE COO & Secretary Dec 24, 2013 Sale $41.00 20,000 819,920 956 Dec 24, 2013, 03:21 PM
PARSHALL B LYNNE COO & Secretary Dec 23, 2013 Sale $41.68 50,000 2,084,050 956 Dec 24, 2013, 03:21 PM
WENDER JOSEPH H Director Dec 19, 2013 Option Exercise $16.32 15,000 244,800 60,866 Dec 20, 2013, 09:27 PM
WENDER JOSEPH H Director Dec 20, 2013 Sale $40.01 10,000 400,125 41,135 Dec 20, 2013, 09:27 PM
WENDER JOSEPH H Director Dec 19, 2013 Sale $39.13 9,731 380,813 51,135 Dec 20, 2013, 09:27 PM
BENNETT C FRANK SVP, Antisense Research Dec 05, 2013 Option Exercise $15.38 10,000 153,800 7,416 Dec 06, 2013, 07:39 PM
BENNETT C FRANK SVP, Antisense Research Dec 05, 2013 Sale $39.92 10,000 399,182 2,866 Dec 06, 2013, 07:39 PM
WENDER JOSEPH H Director Nov 26, 2013 Sale $36.63 10,000 366,336 45,866 Nov 27, 2013, 04:41 PM
KLEIN JOSEPH III Director Nov 25, 2013 Sale $36.86 6,000 221,156 2,313 Nov 27, 2013, 04:40 PM
CROOKE STANLEY T Chairman and CEO Sep 20, 2013 Option Exercise $11.12 8,740 97,189 10,401 Sep 23, 2013, 07:39 PM
CROOKE STANLEY T Chairman and CEO Sep 19, 2013 Option Exercise $11.12 50,000 556,000 31,661 Sep 23, 2013, 07:39 PM
CROOKE STANLEY T Chairman and CEO Sep 20, 2013 Sale $35.90 8,740 313,749 1,661 Sep 23, 2013, 07:39 PM
CROOKE STANLEY T Chairman and CEO Sep 19, 2013 Sale $35.06 50,000 1,753,080 1,661 Sep 23, 2013, 07:39 PM
PARSHALL B LYNNE COO & Secretary Sep 20, 2013 Option Exercise $14.70 40,000 587,900 30,956 Sep 23, 2013, 07:38 PM
PARSHALL B LYNNE COO & Secretary Sep 19, 2013 Option Exercise $16.02 50,000 801,100 30,956 Sep 23, 2013, 07:38 PM
PARSHALL B LYNNE COO & Secretary Sep 20, 2013 Sale $35.90 40,000 1,435,920 956 Sep 23, 2013, 07:38 PM
PARSHALL B LYNNE COO & Secretary Sep 19, 2013 Sale $35.06 50,000 1,753,080 956 Sep 23, 2013, 07:38 PM
Monia Brett P SVP, Antisense Drug Discovery Sep 20, 2013 Option Exercise $11.27 18,281 206,027 19,050 Sep 23, 2013, 07:37 PM
Monia Brett P SVP, Antisense Drug Discovery Sep 19, 2013 Option Exercise $14.75 50,000 737,400 23,269 Sep 23, 2013, 07:37 PM
Monia Brett P SVP, Antisense Drug Discovery Sep 20, 2013 Sale $35.89 18,281 656,105 769 Sep 23, 2013, 07:37 PM
Monia Brett P SVP, Antisense Drug Discovery Sep 19, 2013 Sale $33.59 50,000 1,679,700 769 Sep 23, 2013, 07:37 PM
BENNETT C FRANK SVP, Antisense Research Sep 19, 2013 Option Exercise $15.38 10,000 153,800 12,866 Sep 23, 2013, 07:36 PM
BENNETT C FRANK SVP, Antisense Research Sep 19, 2013 Sale $35.02 10,000 350,200 2,866 Sep 23, 2013, 07:36 PM
CROOKE STANLEY T COO, President Sep 09, 2013 Option Exercise $11.12 26,615 295,959 28,276 Sep 11, 2013, 07:27 PM
CROOKE STANLEY T COO, President Sep 09, 2013 Sale $30.42 26,615 809,495 1,661 Sep 11, 2013, 07:27 PM
CROOKE STANLEY T COO, President Sep 11, 2013 Sale $31.18 20,000 623,620 725,391 Sep 11, 2013, 07:27 PM
CROOKE STANLEY T COO, President Sep 10, 2013 Sale $31.65 30,000 949,440 745,391 Sep 11, 2013, 07:27 PM
BENNETT C FRANK SVP, Antisense Research Sep 09, 2013 Option Exercise $15.38 10,000 153,800 12,866 Sep 11, 2013, 07:26 PM
BENNETT C FRANK SVP, Antisense Research Sep 09, 2013 Sale $30.23 10,000 302,250 2,866 Sep 11, 2013, 07:26 PM
PARSHALL B LYNNE COO Sep 09, 2013 Option Exercise $15.38 30,000 461,400 32,941 Sep 11, 2013, 07:26 PM
PARSHALL B LYNNE COO Sep 11, 2013 Option Exercise $15.38 1,520 23,378 4,461 Sep 11, 2013, 07:26 PM
PARSHALL B LYNNE COO Sep 10, 2013 Option Exercise $15.38 30,000 461,400 32,941 Sep 11, 2013, 07:26 PM
PARSHALL B LYNNE COO Sep 09, 2013 Sale $30.42 30,000 912,450 2,941 Sep 11, 2013, 07:26 PM
PARSHALL B LYNNE COO Sep 11, 2013 Sale $31.18 3,505 109,289 2,941 Sep 11, 2013, 07:26 PM
PARSHALL B LYNNE COO Sep 10, 2013 Sale $31.65 30,000 949,440 2,941 Sep 11, 2013, 07:26 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Sep 04, 2013 Option Exercise $11.29 2,500 28,236 3,340 Sep 06, 2013, 07:03 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Sep 04, 2013 Sale $27.09 2,500 67,731 2,023 Sep 06, 2013, 07:03 PM
Monia Brett P SVP, Antisense Drug Discovery Aug 26, 2013 Sale $25.58 2,909 74,403 769 Aug 28, 2013, 07:19 PM
KLEIN JOSEPH III Director Aug 09, 2013 Option Exercise $10.18 18,750 190,950 15,813 Aug 13, 2013, 07:45 PM
KLEIN JOSEPH III Director Aug 09, 2013 Sale $28.22 18,750 529,126 8,313 Aug 13, 2013, 07:45 PM
CROOKE STANLEY T COO, President Jul 23, 2013 Option Exercise $11.12 11,500 127,880 13,161 Jul 25, 2013, 08:18 PM
CROOKE STANLEY T COO, President Jul 23, 2013 Sale $30.00 11,500 345,000 1,661 Jul 25, 2013, 08:18 PM
CROOKE STANLEY T Chairman and CEO Jul 19, 2013 Option Exercise $15.38 22,200 341,436 11,661 Jul 22, 2013, 07:51 PM
CROOKE STANLEY T Chairman and CEO Jul 18, 2013 Option Exercise $11.12 20,000 222,400 11,661 Jul 22, 2013, 07:51 PM
CROOKE STANLEY T Chairman and CEO Jul 22, 2013 Option Exercise $14.98 20,000 299,570 11,661 Jul 22, 2013, 07:51 PM
CROOKE STANLEY T Chairman and CEO Jul 18, 2013 Sale $30.11 20,000 602,220 1,661 Jul 22, 2013, 07:51 PM
CROOKE STANLEY T Chairman and CEO Jul 22, 2013 Sale $30.77 20,000 615,450 1,661 Jul 22, 2013, 07:51 PM
CROOKE STANLEY T Chairman and CEO Jul 19, 2013 Sale $30.61 22,200 679,650 1,661 Jul 22, 2013, 07:51 PM
CROOKE STANLEY T Chairman and CEO Jul 15, 2013 Option Exercise $11.12 90,000 1,000,800 11,661 Jul 17, 2013, 07:41 PM
CROOKE STANLEY T Chairman and CEO Jul 17, 2013 Option Exercise $13.33 39,900 531,762 8,430 Jul 17, 2013, 07:41 PM
CROOKE STANLEY T Chairman and CEO Jul 16, 2013 Option Exercise $11.12 18,000 200,160 7,661 Jul 17, 2013, 07:41 PM
CROOKE STANLEY T Chairman and CEO Jul 16, 2013 Sale $33.31 18,000 599,526 1,661 Jul 17, 2013, 07:41 PM
CROOKE STANLEY T Chairman and CEO Jul 15, 2013 Sale $33.81 90,000 3,042,540 1,661 Jul 17, 2013, 07:41 PM
CROOKE STANLEY T Chairman and CEO Jul 17, 2013 Sale $31.50 39,900 1,256,876 174 Jul 17, 2013, 07:41 PM
CROOKE STANLEY T Chairman and CEO Jul 11, 2013 Option Exercise $15.38 30,000 461,400 311,661 Jul 12, 2013, 07:44 PM
CROOKE STANLEY T Chairman and CEO Jul 10, 2013 Option Exercise $15.38 30,000 461,400 31,661 Jul 12, 2013, 07:44 PM
CROOKE STANLEY T Chairman and CEO Jul 12, 2013 Option Exercise $11.97 30,000 359,160 13,661 Jul 12, 2013, 07:44 PM
CROOKE STANLEY T Chairman and CEO Jul 10, 2013 Sale $30.05 30,000 901,440 1,661 Jul 12, 2013, 07:44 PM
CROOKE STANLEY T Chairman and CEO Jul 12, 2013 Sale $33.20 30,000 995,998 1,661 Jul 12, 2013, 07:44 PM
CROOKE STANLEY T Chairman and CEO Jul 11, 2013 Sale $32.00 30,000 960,090 1,661 Jul 12, 2013, 07:44 PM
Geary Richard S SVP, Development Jul 11, 2013 Option Exercise $11.12 9,000 100,080 12,446 Jul 12, 2013, 07:43 PM
Geary Richard S SVP, Development Jul 11, 2013 Sale $31.90 9,000 287,100 3,446 Jul 12, 2013, 07:43 PM
Geary Richard S SVP, Development Jul 08, 2013 Option Exercise $11.04 30,000 331,181 21,379 Jul 09, 2013, 08:35 PM
Geary Richard S SVP, Development Jul 05, 2013 Option Exercise $15.13 24,180 365,831 20,406 Jul 09, 2013, 08:35 PM
Geary Richard S SVP, Development Jul 09, 2013 Option Exercise $10.29 10,358 106,584 13,804 Jul 09, 2013, 08:35 PM
Geary Richard S SVP, Development Jul 09, 2013 Sale $30.04 10,358 311,185 3,446 Jul 09, 2013, 08:35 PM
Geary Richard S SVP, Development Jul 05, 2013 Sale $29.97 25,805 773,294 3,446 Jul 09, 2013, 08:35 PM
Geary Richard S SVP, Development Jul 08, 2013 Sale $30.08 30,000 902,380 3,446 Jul 09, 2013, 08:35 PM
CROOKE STANLEY T Chairman and CEO Jul 09, 2013 Option Exercise $15.38 30,000 461,400 31,661 Jul 09, 2013, 07:38 PM
CROOKE STANLEY T Chairman and CEO Jul 05, 2013 Option Exercise $15.38 24,180 371,888 25,841 Jul 09, 2013, 07:38 PM
CROOKE STANLEY T Chairman and CEO Jul 08, 2013 Option Exercise $15.38 5,008 77,023 6,669 Jul 09, 2013, 07:38 PM
CROOKE STANLEY T Chairman and CEO Jul 08, 2013 Sale $23.40 54,992 1,286,756 26,653 Jul 09, 2013, 07:38 PM
CROOKE STANLEY T Chairman and CEO Jul 09, 2013 Sale $30.04 30,000 901,290 1,661 Jul 09, 2013, 07:38 PM
CROOKE STANLEY T Chairman and CEO Jul 05, 2013 Sale $30.01 24,180 725,763 1,661 Jul 09, 2013, 07:38 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jul 01, 2013 Option Exercise $9.20 976 8,976 2,300 Jul 05, 2013, 06:01 PM
O'NEIL PATRICK R. SVP, Legal & General Counsel Jul 05, 2013 Sale $29.25 277 8,102 2,023 Jul 05, 2013, 06:01 PM
Geary Richard S SVP, Development Jul 01, 2013 Option Exercise $9.20 817 7,514 5,071 Jul 03, 2013, 05:16 PM
Geary Richard S SVP, Development Jul 03, 2013 Option Exercise $19.08 5,000 95,400 10,071 Jul 03, 2013, 05:16 PM
Geary Richard S SVP, Development Jul 03, 2013 Sale $29.02 5,000 145,100 5,071 Jul 03, 2013, 05:16 PM
Monia Brett P SVP, Antisense Drug Discovery Jul 01, 2013 Option Exercise $9.20 362 3,329 6,057 Jul 03, 2013, 05:15 PM
Monia Brett P SVP, Antisense Drug Discovery Jul 02, 2013 Sale $28.69 215 6,169 5,842 Jul 03, 2013, 05:15 PM
BENNETT C FRANK SVP, Antisense Research Jul 01, 2013 Option Exercise $9.20 756 6,953 2,866 Jul 03, 2013, 05:13 PM
CROOKE STANLEY T Chairman and CEO Jun 27, 2013 Option Exercise $6.81 20,000 136,200 11,661 Jul 01, 2013, 07:33 PM
CROOKE STANLEY T Chairman and CEO Jun 28, 2013 Option Exercise $9.21 10,683 98,430 6,132 Jul 01, 2013, 07:33 PM
CROOKE STANLEY T Chairman and CEO Jun 28, 2013 Option Exercise $6.81 10,000 68,100 11,661 Jul 01, 2013, 07:33 PM
CROOKE STANLEY T Chairman and CEO Jun 27, 2013 Sale $27.85 20,000 557,000 1,661 Jul 01, 2013, 07:33 PM
CROOKE STANLEY T Chairman and CEO Jun 28, 2013 Sale $27.31 10,683 291,753 174 Jul 01, 2013, 07:33 PM
CROOKE STANLEY T Chairman and CEO Jun 28, 2013 Sale $27.07 10,000 270,700 1,661 Jul 01, 2013, 07:33 PM
CROOKE STANLEY T Chairman and CEO Jul 01, 2013 Sale $28.17 10,000 281,700 775,391 Jul 01, 2013, 07:33 PM
CROOKE STANLEY T Chairman and CEO Jun 26, 2013 Option Exercise $6.81 20,000 136,200 21,661 Jun 26, 2013, 07:46 PM
CROOKE STANLEY T Chairman and CEO Jun 25, 2013 Option Exercise $6.81 30,000 204,300 21,226 Jun 26, 2013, 07:46 PM
CROOKE STANLEY T Chairman and CEO Jun 25, 2013 Sale $28.02 30,000 840,698 1,661 Jun 26, 2013, 07:46 PM
CROOKE STANLEY T Chairman and CEO Jun 26, 2013 Sale $26.70 10,000 267,000 785,391 Jun 26, 2013, 07:46 PM
CROOKE STANLEY T Chairman and CEO Jun 24, 2013 Sale $25.19 30,000 755,624 809,121 Jun 26, 2013, 07:46 PM
CROOKE STANLEY T Chairman and CEO Jun 26, 2013 Sale $27.10 20,000 542,020 1,661 Jun 26, 2013, 07:46 PM
Geary Richard S SVP, Development Jun 25, 2013 Option Exercise $14.21 17,049 242,304 14,689 Jun 26, 2013, 07:45 PM
Geary Richard S SVP, Development Jun 24, 2013 Option Exercise $15.50 30,000 465,100 17,984 Jun 26, 2013, 07:45 PM
Geary Richard S SVP, Development Jun 25, 2013 Sale $27.99 17,049 477,283 4,254 Jun 26, 2013, 07:45 PM
Geary Richard S SVP, Development Jun 24, 2013 Sale $25.19 30,000 755,624 4,254 Jun 26, 2013, 07:45 PM
WENDER JOSEPH H Director Jun 20, 2013 Option Exercise $5.17 10,000 51,700 61,000 Jun 24, 2013, 08:33 PM