| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Meyer Robert J. | Director | Mar 01, 2021 | Buy | $9.80 | 1,500 | 14,700 | 15,000 | Mar 01, 2021, 02:10 PM |
| Jakeman David | Principal Accounting Officer | Jan 28, 2021 | Sale | $8.61 | 3,211 | 27,650 | 96,906 | Jan 29, 2021, 08:13 PM |
| DEMSKI MARTHA J | Director | Nov 17, 2020 | Option Exercise | $2.35 | 7,042 | 16,549 | 7,042 | Nov 19, 2020, 12:57 PM |
| Jakeman David | Principal Accounting Officer | Oct 02, 2020 | Sale | $2.48 | 4,270 | 10,590 | 85,117 | Oct 02, 2020, 04:06 PM |
| Meyer Robert J. | Director | Aug 19, 2020 | Buy | $2.92 | 3,500 | 10,220 | 13,500 | Aug 19, 2020, 05:34 PM |
| DEMSKI MARTHA J | Director | Aug 10, 2020 | Option Exercise | $3.16 | 1,584 | 5,005 | 1,584 | Aug 11, 2020, 05:49 PM |
| DEMSKI MARTHA J | Director | Aug 10, 2020 | Sale | $3.25 | 1,584 | 5,148 | 0 | Aug 11, 2020, 05:49 PM |
| DEMSKI MARTHA J | Director | Aug 06, 2020 | Option Exercise | $3.16 | 2,500 | 7,900 | 2,500 | Aug 10, 2020, 05:54 PM |
| DEMSKI MARTHA J | Director | Aug 07, 2020 | Option Exercise | $3.16 | 2,500 | 7,900 | 2,500 | Aug 10, 2020, 05:54 PM |
| DEMSKI MARTHA J | Director | Aug 07, 2020 | Sale | $3.25 | 2,500 | 8,125 | 0 | Aug 10, 2020, 05:54 PM |
| DEMSKI MARTHA J | Director | Aug 06, 2020 | Sale | $3.29 | 2,500 | 8,224 | 0 | Aug 10, 2020, 05:54 PM |
| DEMSKI MARTHA J | Director | Aug 04, 2020 | Option Exercise | $3.16 | 5,000 | 15,800 | 5,000 | Aug 06, 2020, 12:55 PM |
| DEMSKI MARTHA J | Director | Aug 05, 2020 | Option Exercise | $3.16 | 2,500 | 7,900 | 2,500 | Aug 06, 2020, 12:55 PM |
| DEMSKI MARTHA J | Director | Aug 05, 2020 | Sale | $3.27 | 2,500 | 8,187 | 0 | Aug 06, 2020, 12:55 PM |
| DEMSKI MARTHA J | Director | Aug 04, 2020 | Sale | $3.25 | 5,000 | 16,250 | 0 | Aug 06, 2020, 12:55 PM |
| Andriole Michael T. | Chief Business Officer | Mar 16, 2020 | Buy | $1.43 | 33,300 | 47,522 | 149,729 | Mar 17, 2020, 11:58 AM |
| Sherman Michael A. | Chief Executive Officer | Mar 12, 2020 | Buy | $1.45 | 72,995 | 105,653 | 102,995 | Mar 16, 2020, 12:51 PM |
| MIDDLETON FRED A | Director | Mar 12, 2020 | Buy | $1.40 | 50,000 | 69,900 | 197,523 | Mar 16, 2020, 12:19 PM |
| Nichols Garrett | Chief Medical Officer | Feb 10, 2020 | Sale | $1.68 | 8,805 | 14,830 | 260,066 | Feb 11, 2020, 04:19 PM |
| Nichols Garrett | Chief Medical Officer | Feb 07, 2020 | Sale | $1.70 | 2,550 | 4,335 | 268,871 | Feb 11, 2020, 04:19 PM |
| Jakeman David | Principal Accounting Officer | Feb 07, 2020 | Sale | $1.70 | 2,290 | 3,893 | 87,876 | Feb 11, 2020, 04:16 PM |
| Nichols Garrett | Chief Medical Officer | Jan 07, 2020 | Sale | $2.15 | 30,680 | 66,045 | 271,421 | Jan 08, 2020, 08:18 PM |
| MIDDLETON FRED A | Director | Nov 13, 2019 | Buy | $1.82 | 30,000 | 54,567 | 147,523 | Nov 13, 2019, 04:14 PM |
| MIDDLETON FRED A | Director | Nov 11, 2019 | Buy | $1.66 | 20,000 | 33,190 | 117,523 | Nov 13, 2019, 04:14 PM |
| Andriole Michael T. | Chief Business Officer | Nov 06, 2019 | Buy | $1.56 | 100,000 | 156,000 | 100,000 | Nov 07, 2019, 12:45 PM |
| Meyer Robert J. | Director | Nov 06, 2019 | Buy | $1.58 | 10,000 | 15,797 | 10,000 | Nov 06, 2019, 05:00 PM |
| Nichols Garrett | Chief Medical Officer | Jul 25, 2019 | Option Exercise | $3.49 | 7,625 | 26,634 | 300,056 | Jul 26, 2019, 12:26 PM |
| DEMSKI MARTHA J | Director | May 28, 2019 | Buy | $3.60 | 18,000 | 64,800 | 37,013 | May 29, 2019, 12:29 PM |
| Trost Timothy W. | SVP, CFO & Secretary | May 22, 2019 | Option Exercise | $3.44 | 3,795 | 13,066 | 217,088 | May 22, 2019, 05:28 PM |
| Nichols Garrett | Chief Medical Officer | May 21, 2019 | Option Exercise | $3.47 | 4,695 | 16,270 | 307,681 | May 22, 2019, 12:57 PM |
| Sherman Michael A. | Chief Executive Officer | May 20, 2019 | Buy | $3.48 | 30,000 | 104,316 | 30,000 | May 20, 2019, 04:36 PM |
| MIDDLETON FRED A | Director | May 10, 2019 | Buy | $2.92 | 30,000 | 87,678 | 97,523 | May 13, 2019, 05:21 PM |
| Nichols Garrett | Chief Medical Officer | Jan 29, 2019 | Option Exercise | $2.20 | 3,095 | 6,821 | 212,376 | Jan 30, 2019, 03:20 PM |
| Trost Timothy W. | SVP, CFO & Secretary | Jan 29, 2019 | Option Exercise | $2.20 | 2,588 | 5,694 | 114,530 | Jan 30, 2019, 03:18 PM |
| Berrey M Michelle | President and CEO | Jun 12, 2018 | Buy | $4.50 | 10,000 | 45,015 | 99,685 | Jun 14, 2018, 11:52 AM |
| MARIO ERNEST | Director | May 18, 2018 | Sale | $4.81 | 15,000 | 72,143 | 108,167 | May 21, 2018, 01:34 PM |
| MARIO ERNEST | Director | May 17, 2018 | Sale | $4.80 | 30,000 | 143,931 | 123,167 | May 21, 2018, 01:34 PM |
| MARIO ERNEST | Director | May 16, 2018 | Sale | $4.79 | 30,000 | 143,808 | 153,167 | May 17, 2018, 11:51 AM |
| MARIO ERNEST | Director | May 15, 2018 | Sale | $4.69 | 30,000 | 140,808 | 183,167 | May 16, 2018, 02:46 PM |
| MARIO ERNEST | Director | May 14, 2018 | Sale | $4.67 | 22,553 | 105,232 | 213,167 | May 15, 2018, 03:41 PM |
| MARIO ERNEST | Director | May 11, 2018 | Sale | $4.61 | 30,000 | 138,380 | 258,577 | May 15, 2018, 03:41 PM |
| Nichols Garrett | Chief Medical Officer | May 14, 2018 | Option Exercise | $4.66 | 5,680 | 26,490 | 90,471 | May 15, 2018, 01:44 PM |
| Richardson Linda M | Chief Commercial Officer | May 14, 2018 | Option Exercise | $4.66 | 4,545 | 21,199 | 54,161 | May 15, 2018, 01:42 PM |
| MARIO ERNEST | Director | May 10, 2018 | Sale | $4.60 | 2,815 | 12,949 | 265,720 | May 11, 2018, 05:25 PM |
| Berrey M Michelle | President and CEO | May 08, 2018 | Option Exercise | $4.26 | 11,250 | 47,925 | 325,256 | May 10, 2018, 05:34 PM |
| DEMSKI MARTHA J | Director | May 09, 2018 | Option Exercise | $1.57 | 4,225 | 6,633 | 19,013 | May 10, 2018, 03:20 PM |
| Berrey M Michelle | President and CEO | Mar 06, 2018 | Option Exercise | $4.26 | 10,071 | 42,902 | 311,336 | Mar 08, 2018, 04:53 PM |
| Richardson Linda M | Chief Commercial Officer | Feb 02, 2018 | Option Exercise | $4.67 | 2,290 | 10,691 | 58,706 | Feb 05, 2018, 07:44 PM |
| Nichols Garrett | Chief Medical Officer | Feb 02, 2018 | Option Exercise | $4.67 | 2,330 | 10,872 | 96,151 | Feb 05, 2018, 07:42 PM |
| Richardson Linda M | Chief Commercial Officer | Dec 01, 2017 | Sale | $4.47 | 19,833 | 88,673 | 60,996 | Dec 05, 2017, 02:08 PM |
| Berrey M Michelle | President and CEO | Jun 21, 2017 | Option Exercise | $4.26 | 23,474 | 99,999 | 323,947 | Jun 22, 2017, 04:21 PM |
| Nichols Garrett | Chief Medical Officer | May 12, 2017 | Option Exercise | $4.68 | 12,712 | 59,464 | 98,481 | May 16, 2017, 05:46 PM |
| Richardson Linda M | Chief Commercial Officer | May 12, 2017 | Option Exercise | $4.68 | 10,167 | 47,577 | 80,829 | May 16, 2017, 05:45 PM |
| Trost Timothy W. | SVP, CFO & Secretary | Mar 10, 2017 | Option Exercise | $4.10 | 5,186 | 21,247 | 111,931 | Mar 31, 2017, 04:55 PM |
| Nichols Garrett | Chief Medical Officer | Mar 10, 2017 | Option Exercise | $4.10 | 587 | 2,405 | 111,193 | Mar 31, 2017, 04:53 PM |
| Berrey M Michelle | President and CEO | Mar 10, 2017 | Option Exercise | $4.10 | 4,523 | 18,531 | 366,684 | Mar 31, 2017, 04:52 PM |
| MARIO ERNEST | Director | Dec 28, 2016 | Sale | $4.54 | 24,291 | 110,317 | 288,826 | Dec 29, 2016, 04:03 PM |
| MARIO ERNEST | Director | Dec 27, 2016 | Sale | $4.68 | 75,709 | 354,050 | 296,462 | Dec 29, 2016, 04:03 PM |
| Berrey M Michelle | President and CEO | Nov 29, 2016 | Option Exercise | $4.26 | 2,400 | 10,224 | 288,161 | Dec 01, 2016, 04:17 PM |
| Trost Timothy W. | SVP, CFO & Secretary | Sep 09, 2016 | Option Exercise | $4.05 | 4,638 | 18,784 | 81,370 | Sep 19, 2016, 05:22 PM |
| Nichols Garrett | Chief Medical Officer | Sep 09, 2016 | Option Exercise | $4.05 | 3,566 | 14,442 | 80,231 | Sep 19, 2016, 05:19 PM |
| Berrey M Michelle | President and CEO | Sep 09, 2016 | Option Exercise | $4.05 | 4,523 | 18,318 | 285,761 | Sep 19, 2016, 05:17 PM |
| LEONARD JOHN M. | Director | Sep 15, 2016 | Sale | $5.03 | 5,000 | 25,162 | 0 | Sep 16, 2016, 06:46 PM |
| Berrey M Michelle | President and CEO | Aug 29, 2016 | Buy | $4.47 | 22,417 | 100,226 | 281,238 | Aug 31, 2016, 03:01 PM |
| MARIO ERNEST | Director | Jun 24, 2016 | Buy | $3.70 | 50,000 | 184,845 | 381,440 | Jun 28, 2016, 03:17 PM |
| Berrey M Michelle | President and CEO | Jun 24, 2016 | Buy | $3.69 | 13,188 | 48,624 | 258,821 | Jun 28, 2016, 03:16 PM |
| MARIO ERNEST | Director | May 13, 2016 | Buy | $4.53 | 10,000 | 45,328 | 331,440 | May 16, 2016, 01:56 PM |
| MARIO ERNEST | Director | May 11, 2016 | Buy | $4.85 | 24,200 | 117,365 | 321,440 | May 11, 2016, 05:15 PM |
| MARIO ERNEST | Director | May 10, 2016 | Buy | $4.76 | 800 | 3,804 | 297,240 | May 11, 2016, 05:15 PM |
| MARIO ERNEST | Director | May 04, 2016 | Option Exercise | $5.05 | 1,761 | 8,893 | 296,440 | May 05, 2016, 05:05 PM |
| MARIO ERNEST | Director | Apr 04, 2016 | Option Exercise | $5.05 | 1,760 | 8,888 | 294,679 | Apr 05, 2016, 05:56 PM |
| MARIO ERNEST | Director | Mar 16, 2016 | Buy | $4.78 | 5,000 | 23,898 | 292,919 | Mar 16, 2016, 05:15 PM |
| MARIO ERNEST | Director | Mar 15, 2016 | Buy | $5.13 | 20,000 | 102,628 | 287,919 | Mar 16, 2016, 05:15 PM |
| MARIO ERNEST | Director | Mar 07, 2016 | Option Exercise | $5.05 | 1,761 | 8,893 | 267,919 | Mar 09, 2016, 01:59 PM |
| Berrey M Michelle | President and CEO | Mar 01, 2016 | Option Exercise | $4.26 | 11,001 | 46,864 | 145,633 | Mar 03, 2016, 02:34 PM |
| WOLLAEGER TIMOTHY | Director | Mar 01, 2016 | Buy | $4.61 | 10,000 | 46,100 | 10,000 | Mar 02, 2016, 02:59 PM |
| DEMSKI MARTHA J | Director | Mar 01, 2016 | Buy | $4.89 | 10,000 | 48,900 | 10,000 | Mar 02, 2016, 02:58 PM |
| MARIO ERNEST | Director | Feb 08, 2016 | Option Exercise | $5.05 | 1,760 | 8,888 | 266,158 | Feb 09, 2016, 02:06 PM |
| MARIO ERNEST | Director | Jan 13, 2016 | Option Exercise | $5.05 | 1,761 | 8,893 | 264,398 | Jan 14, 2016, 01:49 PM |
| Machado Clarence Patrick | Director | Dec 29, 2015 | Buy | $7.08 | 10,000 | 70,846 | 10,000 | Dec 30, 2015, 02:33 PM |
| MARIO ERNEST | Director | Dec 29, 2015 | Buy | $7.09 | 125,000 | 886,612 | 262,637 | Dec 30, 2015, 02:32 PM |
| MARIO ERNEST | Director | Dec 09, 2015 | Option Exercise | $5.05 | 1,760 | 8,888 | 137,637 | Dec 11, 2015, 01:45 PM |
| MARIO ERNEST | Director | Nov 06, 2015 | Option Exercise | $5.05 | 1,761 | 8,893 | 135,877 | Nov 10, 2015, 04:07 PM |
| DEMSKI MARTHA J | Director | Nov 02, 2015 | Option Exercise | $1.53 | 1,126 | 1,723 | 1,126 | Nov 03, 2015, 05:41 PM |
| DEMSKI MARTHA J | Director | Nov 02, 2015 | Sale | $41.35 | 1,126 | 46,561 | 1,026 | Nov 03, 2015, 05:41 PM |
| MARIO ERNEST | Director | Oct 06, 2015 | Option Exercise | $5.05 | 1,761 | 8,893 | 134,116 | Oct 07, 2015, 03:07 PM |
| DEMSKI MARTHA J | Director | Oct 01, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | Oct 02, 2015, 02:43 PM |
| DEMSKI MARTHA J | Director | Oct 01, 2015 | Sale | $37.68 | 2,000 | 75,368 | 200 | Oct 02, 2015, 02:43 PM |
| MARIO ERNEST | Director | Sep 04, 2015 | Option Exercise | $17.92 | 2,592 | 46,453 | 132,355 | Sep 08, 2015, 01:30 PM |
| DEMSKI MARTHA J | Director | Sep 01, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | Sep 03, 2015, 11:50 AM |
| DEMSKI MARTHA J | Director | Sep 01, 2015 | Sale | $48.18 | 2,000 | 96,366 | 438 | Sep 03, 2015, 11:50 AM |
| Berrey M Michelle | President and CEO | Aug 26, 2015 | Option Exercise | $18.75 | 2,796 | 52,425 | 133,434 | Aug 27, 2015, 04:16 PM |
| LEONARD JOHN M. | Director | Aug 21, 2015 | Buy | $47.38 | 1,000 | 47,380 | 1,000 | Aug 25, 2015, 02:25 PM |
| Trost Timothy W. | SVP, CFO & Secretary | Aug 12, 2015 | Option Exercise | $18.75 | 5,333 | 99,994 | 15,183 | Aug 13, 2015, 02:56 PM |
| MARIO ERNEST | Director | Aug 06, 2015 | Option Exercise | $14.49 | 5,232 | 75,791 | 129,763 | Aug 07, 2015, 02:49 PM |
| DEMSKI MARTHA J | Director | Aug 03, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | Aug 05, 2015, 04:52 PM |
| DEMSKI MARTHA J | Director | Aug 03, 2015 | Sale | $54.61 | 2,000 | 109,228 | 0 | Aug 05, 2015, 04:52 PM |
| Trost Timothy W. | SVP, CFO & Secretary | Jul 17, 2015 | Option Exercise | $2.35 | 28,000 | 65,800 | 37,850 | Jul 20, 2015, 05:02 PM |
| Trost Timothy W. | SVP, CFO & Secretary | Jul 17, 2015 | Sale | $50.00 | 28,000 | 1,400,000 | 9,850 | Jul 20, 2015, 05:02 PM |
| DEMSKI MARTHA J | Director | Jul 01, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | Jul 02, 2015, 04:42 PM |
| DEMSKI MARTHA J | Director | Jul 01, 2015 | Sale | $46.03 | 2,000 | 92,051 | 700 | Jul 02, 2015, 04:42 PM |
| MARIO ERNEST | Director | Jun 10, 2015 | Option Exercise | $11.11 | 5,279 | 58,672 | 124,531 | Jun 11, 2015, 02:31 PM |
| DEMSKI MARTHA J | Director | Jun 01, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | Jun 03, 2015, 02:49 PM |
| DEMSKI MARTHA J | Director | Jun 01, 2015 | Sale | $41.58 | 2,000 | 83,164 | 0 | Jun 03, 2015, 02:49 PM |
| Ricciardi Lisa | Director | May 12, 2015 | Buy | $38.54 | 1,950 | 75,153 | 1,950 | May 14, 2015, 12:46 PM |
| DEMSKI MARTHA J | Director | May 01, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | May 04, 2015, 05:04 PM |
| DEMSKI MARTHA J | Director | May 01, 2015 | Sale | $34.71 | 2,000 | 69,420 | 0 | May 04, 2015, 05:04 PM |
| MARIO ERNEST | Director | Apr 06, 2015 | Option Exercise | $11.12 | 2,641 | 29,362 | 119,252 | Apr 07, 2015, 04:08 PM |
| DEMSKI MARTHA J | Director | Apr 01, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | Apr 03, 2015, 01:09 PM |
| DEMSKI MARTHA J | Director | Apr 01, 2015 | Sale | $36.88 | 2,000 | 73,752 | 300 | Apr 03, 2015, 01:09 PM |
| Rogers Michael D. | Chief Development Officer | Mar 23, 2015 | Option Exercise | $7.57 | 6,372 | 48,236 | 21,630 | Mar 25, 2015, 03:02 PM |
| Berrey M Michelle | President and CEO | Mar 20, 2015 | Option Exercise | $10.53 | 12,926 | 136,078 | 130,638 | Mar 24, 2015, 02:25 PM |
| MARIO ERNEST | Director | Mar 18, 2015 | Option Exercise | $11.11 | 5,279 | 58,672 | 116,611 | Mar 20, 2015, 02:41 PM |
| DEMSKI MARTHA J | Director | Mar 02, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | Mar 03, 2015, 03:41 PM |
| DEMSKI MARTHA J | Director | Mar 02, 2015 | Sale | $40.18 | 2,000 | 80,350 | 500 | Mar 03, 2015, 03:41 PM |
| DEMSKI MARTHA J | Director | Feb 02, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | Feb 03, 2015, 02:36 PM |
| DEMSKI MARTHA J | Director | Feb 02, 2015 | Sale | $38.38 | 2,000 | 76,769 | 0 | Feb 03, 2015, 02:36 PM |
| Berrey M Michelle | President and CEO | Jan 21, 2015 | Option Exercise | $4.26 | 3,668 | 15,626 | 116,282 | Jan 22, 2015, 01:18 PM |
| MARIO ERNEST | Director | Jan 16, 2015 | Option Exercise | $11.11 | 5,279 | 58,672 | 111,332 | Jan 20, 2015, 05:50 PM |
| DEMSKI MARTHA J | Director | Jan 02, 2015 | Option Exercise | $1.53 | 2,000 | 3,060 | 2,000 | Jan 06, 2015, 04:40 PM |
| DEMSKI MARTHA J | Director | Jan 02, 2015 | Sale | $41.08 | 2,000 | 82,154 | 0 | Jan 06, 2015, 04:40 PM |
| Berrey M Michelle | President and CEO | Dec 22, 2014 | Option Exercise | $4.26 | 14,672 | 62,503 | 112,614 | Dec 23, 2014, 06:15 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Dec 12, 2014 | Option Exercise | $18.75 | 5,333 | 99,994 | 9,172 | Dec 16, 2014, 01:43 PM |
| MARIO ERNEST | Director | Nov 04, 2014 | Option Exercise | $12.33 | 8,799 | 108,480 | 96,053 | Nov 06, 2014, 04:56 PM |
| MARIO ERNEST | Director | Nov 05, 2014 | Buy | $29.00 | 10,000 | 290,000 | 106,053 | Nov 06, 2014, 04:56 PM |
| LEONARD JOHN M. | Director | Nov 05, 2014 | Buy | $29.00 | 4,000 | 116,000 | 4,000 | Nov 06, 2014, 04:50 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Sep 25, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 8,839 | Sep 29, 2014, 03:27 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Sep 25, 2014 | Sale | $27.75 | 5,000 | 138,774 | 3,839 | Sep 29, 2014, 03:27 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Aug 25, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 8,182 | Sep 29, 2014, 03:23 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Aug 25, 2014 | Sale | $25.13 | 5,000 | 125,672 | 3,182 | Sep 29, 2014, 03:23 PM |
| NIEDEL JAMES | Director | Sep 09, 2014 | Sale | $28.86 | 326,952 | 9,436,468 | 1,417,321 | Sep 11, 2014, 05:34 PM |
| NIEDEL JAMES | Director | Sep 11, 2014 | Sale | $29.58 | 328,680 | 9,722,354 | 1,046,082 | Sep 11, 2014, 05:34 PM |
| NIEDEL JAMES | Director | Sep 10, 2014 | Sale | $29.65 | 444,317 | 13,172,718 | 1,374,762 | Sep 11, 2014, 05:34 PM |
| NIEDEL JAMES | Director | Sep 10, 2014 | Option Exercise | $7.26 | 401,758 | 2,916,763 | 1,471,891 | Sep 11, 2014, 05:34 PM |
| NIEDEL JAMES | Director | Sep 09, 2014 | Option Exercise | $7.26 | 200,879 | 1,458,382 | 1,468,421 | Sep 11, 2014, 05:34 PM |
| WOLLAEGER TIMOTHY | Director | Sep 09, 2014 | Sale | $29.28 | 122,950 | 3,599,374 | 3,930,700 | Sep 10, 2014, 06:49 PM |
| Sanderling Venture Partners V, LP | 10% Owner | Sep 09, 2014 | Sale | $29.28 | 122,950 | 3,599,374 | 993,646 | Sep 10, 2014, 06:47 PM |
| Sanderling Venture Partners VI Co Investment Fund LP | 10% Owner | Sep 08, 2014 | Sale | $24.61 | 92,265 | 2,270,632 | 697,346 | Sep 09, 2014, 04:31 PM |
| Sanderling Venture Partners VI Co Investment Fund LP | 10% Owner | Sep 05, 2014 | Sale | $23.66 | 7,735 | 183,027 | 789,611 | Sep 09, 2014, 04:31 PM |
| WOLLAEGER TIMOTHY | Director | Sep 05, 2014 | Sale | $23.66 | 7,735 | 183,027 | 4,145,915 | Sep 09, 2014, 04:26 PM |
| WOLLAEGER TIMOTHY | Director | Sep 08, 2014 | Sale | $24.61 | 92,265 | 2,270,632 | 4,053,650 | Sep 09, 2014, 04:26 PM |
| MARIO ERNEST | Director | Sep 05, 2014 | Buy | $23.19 | 10,000 | 231,872 | 87,254 | Sep 08, 2014, 03:44 PM |
| Berrey M Michelle | President and CEO | Sep 02, 2014 | Option Exercise | $4.26 | 14,671 | 62,498 | 97,942 | Sep 04, 2014, 03:09 PM |
| MARIO ERNEST | Director | Aug 26, 2014 | Option Exercise | $5.05 | 8,803 | 44,455 | 77,254 | Aug 27, 2014, 04:31 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Aug 25, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,629 | Aug 26, 2014, 12:17 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Aug 25, 2014 | Sale | $25.13 | 5,000 | 125,672 | 629 | Aug 26, 2014, 12:17 PM |
| Trost Timothy W. | See Remarks | Jul 25, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,629 | Jul 29, 2014, 04:10 PM |
| Trost Timothy W. | See Remarks | Jul 28, 2014 | Option Exercise | $2.35 | 2,553 | 6,000 | 3,182 | Jul 29, 2014, 04:10 PM |
| Trost Timothy W. | See Remarks | Jul 25, 2014 | Sale | $22.35 | 5,000 | 111,762 | 629 | Jul 29, 2014, 04:10 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Jun 25, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,629 | Jun 27, 2014, 12:01 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Jun 25, 2014 | Sale | $22.74 | 5,000 | 113,697 | 629 | Jun 27, 2014, 12:01 PM |
| Berrey M Michelle | See Remarks | May 21, 2014 | Option Exercise | $4.26 | 18,339 | 78,124 | 69,206 | May 28, 2014, 02:23 PM |
| MARIO ERNEST | Director | May 27, 2014 | Buy | $14.22 | 10,000 | 142,200 | 68,451 | May 28, 2014, 02:16 PM |
| Trost Timothy W. | SVP and CFO | May 27, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,629 | May 28, 2014, 02:09 PM |
| Trost Timothy W. | SVP and CFO | May 27, 2014 | Sale | $17.41 | 5,000 | 87,067 | 629 | May 28, 2014, 02:09 PM |
| Berrey M Michelle | See Remarks | May 27, 2014 | Buy | $14.22 | 14,065 | 200,004 | 83,271 | May 28, 2014, 02:05 PM |
| Berrey M Michelle | See Remarks | May 21, 2014 | Option Exercise | $4.26 | 18,330 | 78,086 | 69,197 | May 22, 2014, 04:59 PM |
| Trost Timothy W. | See Remarks | Apr 25, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,629 | Apr 29, 2014, 06:08 PM |
| Trost Timothy W. | See Remarks | Apr 25, 2014 | Sale | $18.67 | 5,000 | 93,325 | 629 | Apr 29, 2014, 06:08 PM |
| Rogers Michael D. | Chief Development Officer | Apr 25, 2014 | Option Exercise | $7.57 | 13,000 | 98,410 | 13,870 | Apr 29, 2014, 03:14 PM |
| MARIO ERNEST | Director | Apr 01, 2014 | Option Exercise | $5.05 | 7,047 | 35,587 | 58,451 | Apr 01, 2014, 05:06 PM |
| Trost Timothy W. | Sr. VP and CFO | Mar 25, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,000 | Mar 26, 2014, 12:29 PM |
| Trost Timothy W. | Sr. VP and CFO | Mar 25, 2014 | Sale | $25.37 | 5,000 | 126,862 | 0 | Mar 26, 2014, 12:29 PM |
| MOCH KENNETH I | President and CEO | Mar 13, 2014 | Option Exercise | $1.57 | 15,000 | 23,550 | 20,292 | Mar 17, 2014, 09:31 PM |
| MOCH KENNETH I | President and CEO | Mar 13, 2014 | Sale | $25.00 | 18,979 | 474,475 | 1,313 | Mar 17, 2014, 09:31 PM |
| MOCH KENNETH I | President and CEO | Feb 24, 2014 | Option Exercise | $1.57 | 9,072 | 14,243 | 15,051 | Feb 26, 2014, 03:40 PM |
| MOCH KENNETH I | President and CEO | Feb 24, 2014 | Sale | $20.00 | 11,072 | 221,440 | 3,979 | Feb 26, 2014, 03:40 PM |
| Trost Timothy W. | Sr. VP & CFO | Feb 25, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,000 | Feb 26, 2014, 03:34 PM |
| Trost Timothy W. | Sr. VP & CFO | Feb 25, 2014 | Sale | $19.29 | 5,000 | 96,470 | 0 | Feb 26, 2014, 03:34 PM |
| MOCH KENNETH I | President and CEO | Jan 30, 2014 | Option Exercise | $1.57 | 928 | 1,457 | 6,907 | Feb 03, 2014, 08:22 PM |
| MOCH KENNETH I | President and CEO | Jan 30, 2014 | Sale | $20.00 | 928 | 18,560 | 5,979 | Feb 03, 2014, 08:22 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Jan 27, 2014 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,000 | Jan 28, 2014, 06:41 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Jan 27, 2014 | Sale | $18.26 | 5,000 | 91,294 | 0 | Jan 28, 2014, 06:41 PM |
| Trost Timothy W. | Sr. VP and CFO | Dec 26, 2013 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,000 | Dec 30, 2013, 05:49 PM |
| Trost Timothy W. | Sr. VP and CFO | Dec 26, 2013 | Sale | $15.21 | 5,000 | 76,073 | 0 | Dec 30, 2013, 05:49 PM |
| MARIO ERNEST | Director | Dec 13, 2013 | Buy | $13.90 | 5,000 | 69,500 | 51,404 | Dec 13, 2013, 06:27 PM |
| DRAKE RODMAN L | Director | Dec 09, 2013 | Buy | $14.35 | 1,000 | 14,350 | 3,500 | Dec 09, 2013, 06:49 PM |
| Trost Timothy W. | SVP, CFO & Secretary | Nov 25, 2013 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,000 | Nov 26, 2013, 03:34 PM |
| Trost Timothy W. | SVP, CFO & Secretary | Nov 25, 2013 | Sale | $14.99 | 5,000 | 74,934 | 0 | Nov 26, 2013, 03:34 PM |
| DRAKE RODMAN L | Director | Nov 25, 2013 | Buy | $15.01 | 1,000 | 15,010 | 2,500 | Nov 26, 2013, 03:31 PM |
| MARIO ERNEST | Director | Nov 25, 2013 | Buy | $15.20 | 8,000 | 121,600 | 46,404 | Nov 25, 2013, 06:17 PM |
| DRAKE RODMAN L | Director | Nov 22, 2013 | Buy | $15.55 | 449 | 6,982 | 1,500 | Nov 22, 2013, 03:42 PM |
| DRAKE RODMAN L | Director | Nov 20, 2013 | Buy | $15.00 | 51 | 765 | 1,051 | Nov 22, 2013, 03:42 PM |
| MARIO ERNEST | Director | Nov 19, 2013 | Option Exercise | $5.05 | 15,840 | 79,992 | 38,404 | Nov 20, 2013, 05:14 PM |
| MARIO ERNEST | Director | Nov 19, 2013 | Buy | $15.25 | 7,500 | 114,375 | 22,564 | Nov 20, 2013, 05:14 PM |
| DRAKE RODMAN L | Director | Nov 15, 2013 | Buy | $15.56 | 1,000 | 15,557 | 1,000 | Nov 19, 2013, 05:01 PM |
| Trost Timothy W. | SVP, CFO & Secretary | Nov 15, 2013 | Sale | $15.63 | 3,409 | 53,274 | 0 | Nov 19, 2013, 03:08 PM |
| MOCH KENNETH I | President and CEO | Nov 15, 2013 | Sale | $15.62 | 2,500 | 39,041 | 5,979 | Nov 19, 2013, 03:07 PM |
| Berrey M Michelle | Chief Medical Officer | Nov 15, 2013 | Option Exercise | $4.26 | 44,014 | 187,500 | 49,554 | Nov 19, 2013, 03:06 PM |
| Trost Timothy W. | Sr. Vice President and CFO | Oct 25, 2013 | Option Exercise | $2.35 | 5,000 | 11,750 | 5,000 | Oct 29, 2013, 10:52 AM |
| Trost Timothy W. | Sr. Vice President and CFO | Oct 25, 2013 | Sale | $16.04 | 5,000 | 80,187 | 0 | Oct 29, 2013, 10:52 AM |
| CHAMPSI FARAH | Director | Oct 23, 2013 | Sale | $15.51 | 447,499 | 6,940,710 | 1,714,330 | Oct 23, 2013, 06:31 PM |
| Hutton Wende S | Director | Oct 23, 2013 | Sale | $15.51 | 674,771 | 10,465,698 | 2,584,990 | Oct 23, 2013, 06:29 PM |
| PAPPAS ARTHUR M | Director | Oct 23, 2013 | Sale | $15.51 | 216,840 | 3,363,188 | 830,695 | Oct 23, 2013, 06:27 PM |
| Canaan VII L P | Director | Oct 23, 2013 | Sale | $15.51 | 674,771 | 10,465,698 | 2,584,990 | Oct 23, 2013, 06:25 PM |
| NIEDEL JAMES | Director | Oct 23, 2013 | Sale | $15.51 | 585,602 | 9,082,687 | 2,243,394 | Oct 23, 2013, 06:22 PM |
| New Leaf Ventures II, L.P. | 10% Owner | Oct 23, 2013 | Sale | $15.51 | 1,171,204 | 18,165,374 | 2,243,394 | Oct 23, 2013, 06:20 PM |
| MARIO ERNEST | Director | Aug 29, 2013 | Buy | $15.83 | 4,214 | 66,706 | 14,214 | Sep 03, 2013, 05:16 PM |
| MARIO ERNEST | Director | Aug 30, 2013 | Buy | $15.80 | 850 | 13,427 | 15,064 | Sep 03, 2013, 05:16 PM |
| MARIO ERNEST | Director | Aug 26, 2013 | Buy | $17.20 | 5,960 | 102,500 | 10,000 | Aug 27, 2013, 06:20 PM |
| Berrey M Michelle | Chief Medical Officer | Aug 23, 2013 | Buy | $18.70 | 5,540 | 103,598 | 5,540 | Aug 26, 2013, 07:05 PM |
| MARIO ERNEST | Director | Aug 19, 2013 | Buy | $17.50 | 2,000 | 35,000 | 4,000 | Aug 20, 2013, 08:30 PM |
| MARIO ERNEST | Director | Aug 16, 2013 | Buy | $17.45 | 2,000 | 34,900 | 2,000 | Aug 20, 2013, 08:30 PM |
| MARIO ERNEST | Director | Aug 20, 2013 | Buy | $17.50 | 40 | 700 | 4,040 | Aug 20, 2013, 08:30 PM |
| Hutton Wende S | Director | Apr 16, 2013 | Option Exercise | $7.26 | 211,783 | 1,537,545 | 3,272,158 | Apr 18, 2013, 03:35 PM |
| Canaan VII L P | Director | Apr 16, 2013 | Option Exercise | $7.26 | 211,783 | 1,537,545 | 3,259,761 | Apr 18, 2013, 03:29 PM |
| Owner | Relationship | Date | Transaction | Value($) |
| Meyer Robert J. | Director | Mar 01, 2021 | Buy | 14,700 |
| Jakeman David | Principal Accounting Officer | Jan 28, 2021 | Sale | 27,650 |
| DEMSKI MARTHA J | Director | Nov 17, 2020 | Option Exercise | 16,549 |
| Jakeman David | Principal Accounting Officer | Oct 02, 2020 | Sale | 10,590 |
| Meyer Robert J. | Director | Aug 19, 2020 | Buy | 10,220 |
| DEMSKI MARTHA J | Director | Aug 10, 2020 | Option Exercise | 5,005 |
| DEMSKI MARTHA J | Director | Aug 10, 2020 | Sale | 5,148 |
| DEMSKI MARTHA J | Director | Aug 06, 2020 | Option Exercise | 7,900 |
| DEMSKI MARTHA J | Director | Aug 07, 2020 | Option Exercise | 7,900 |
| DEMSKI MARTHA J | Director | Aug 07, 2020 | Sale | 8,125 |
| DEMSKI MARTHA J | Director | Aug 06, 2020 | Sale | 8,224 |
| DEMSKI MARTHA J | Director | Aug 04, 2020 | Option Exercise | 15,800 |
| DEMSKI MARTHA J | Director | Aug 05, 2020 | Option Exercise | 7,900 |
| DEMSKI MARTHA J | Director | Aug 05, 2020 | Sale | 8,187 |
| DEMSKI MARTHA J | Director | Aug 04, 2020 | Sale | 16,250 |
| Andriole Michael T. | Chief Business Officer | Mar 16, 2020 | Buy | 47,522 |
| Sherman Michael A. | Chief Executive Officer | Mar 12, 2020 | Buy | 105,653 |
| MIDDLETON FRED A | Director | Mar 12, 2020 | Buy | 69,900 |
| Nichols Garrett | Chief Medical Officer | Feb 10, 2020 | Sale | 14,830 |
| Nichols Garrett | Chief Medical Officer | Feb 07, 2020 | Sale | 4,335 |
| Jakeman David | Principal Accounting Officer | Feb 07, 2020 | Sale | 3,893 |
| Nichols Garrett | Chief Medical Officer | Jan 07, 2020 | Sale | 66,045 |
| MIDDLETON FRED A | Director | Nov 13, 2019 | Buy | 54,567 |
| MIDDLETON FRED A | Director | Nov 11, 2019 | Buy | 33,190 |
| Andriole Michael T. | Chief Business Officer | Nov 06, 2019 | Buy | 156,000 |
| Meyer Robert J. | Director | Nov 06, 2019 | Buy | 15,797 |
| Nichols Garrett | Chief Medical Officer | Jul 25, 2019 | Option Exercise | 26,634 |
| DEMSKI MARTHA J | Director | May 28, 2019 | Buy | 64,800 |
| Trost Timothy W. | SVP, CFO & Secretary | May 22, 2019 | Option Exercise | 13,066 |
| Nichols Garrett | Chief Medical Officer | May 21, 2019 | Option Exercise | 16,270 |
| Sherman Michael A. | Chief Executive Officer | May 20, 2019 | Buy | 104,316 |
| MIDDLETON FRED A | Director | May 10, 2019 | Buy | 87,678 |
| Nichols Garrett | Chief Medical Officer | Jan 29, 2019 | Option Exercise | 6,821 |
| Trost Timothy W. | SVP, CFO & Secretary | Jan 29, 2019 | Option Exercise | 5,694 |
| Berrey M Michelle | President and CEO | Jun 12, 2018 | Buy | 45,015 |
| MARIO ERNEST | Director | May 18, 2018 | Sale | 72,143 |
| MARIO ERNEST | Director | May 17, 2018 | Sale | 143,931 |
| MARIO ERNEST | Director | May 16, 2018 | Sale | 143,808 |
| MARIO ERNEST | Director | May 15, 2018 | Sale | 140,808 |
| MARIO ERNEST | Director | May 14, 2018 | Sale | 105,232 |
| MARIO ERNEST | Director | May 11, 2018 | Sale | 138,380 |
| Nichols Garrett | Chief Medical Officer | May 14, 2018 | Option Exercise | 26,490 |
| Richardson Linda M | Chief Commercial Officer | May 14, 2018 | Option Exercise | 21,199 |
| MARIO ERNEST | Director | May 10, 2018 | Sale | 12,949 |
| Berrey M Michelle | President and CEO | May 08, 2018 | Option Exercise | 47,925 |
| DEMSKI MARTHA J | Director | May 09, 2018 | Option Exercise | 6,633 |
| Berrey M Michelle | President and CEO | Mar 06, 2018 | Option Exercise | 42,902 |
| Richardson Linda M | Chief Commercial Officer | Feb 02, 2018 | Option Exercise | 10,691 |
| Nichols Garrett | Chief Medical Officer | Feb 02, 2018 | Option Exercise | 10,872 |
| Richardson Linda M | Chief Commercial Officer | Dec 01, 2017 | Sale | 88,673 |
| Berrey M Michelle | President and CEO | Jun 21, 2017 | Option Exercise | 99,999 |
| Nichols Garrett | Chief Medical Officer | May 12, 2017 | Option Exercise | 59,464 |
| Richardson Linda M | Chief Commercial Officer | May 12, 2017 | Option Exercise | 47,577 |
| Trost Timothy W. | SVP, CFO & Secretary | Mar 10, 2017 | Option Exercise | 21,247 |
| Nichols Garrett | Chief Medical Officer | Mar 10, 2017 | Option Exercise | 2,405 |
| Berrey M Michelle | President and CEO | Mar 10, 2017 | Option Exercise | 18,531 |
| MARIO ERNEST | Director | Dec 28, 2016 | Sale | 110,317 |
| MARIO ERNEST | Director | Dec 27, 2016 | Sale | 354,050 |
| Berrey M Michelle | President and CEO | Nov 29, 2016 | Option Exercise | 10,224 |
| Trost Timothy W. | SVP, CFO & Secretary | Sep 09, 2016 | Option Exercise | 18,784 |
| Nichols Garrett | Chief Medical Officer | Sep 09, 2016 | Option Exercise | 14,442 |
| Berrey M Michelle | President and CEO | Sep 09, 2016 | Option Exercise | 18,318 |
| LEONARD JOHN M. | Director | Sep 15, 2016 | Sale | 25,162 |
| Berrey M Michelle | President and CEO | Aug 29, 2016 | Buy | 100,226 |
| MARIO ERNEST | Director | Jun 24, 2016 | Buy | 184,845 |
| Berrey M Michelle | President and CEO | Jun 24, 2016 | Buy | 48,624 |
| MARIO ERNEST | Director | May 13, 2016 | Buy | 45,328 |
| MARIO ERNEST | Director | May 11, 2016 | Buy | 117,365 |
| MARIO ERNEST | Director | May 10, 2016 | Buy | 3,804 |
| MARIO ERNEST | Director | May 04, 2016 | Option Exercise | 8,893 |
| MARIO ERNEST | Director | Apr 04, 2016 | Option Exercise | 8,888 |
| MARIO ERNEST | Director | Mar 16, 2016 | Buy | 23,898 |
| MARIO ERNEST | Director | Mar 15, 2016 | Buy | 102,628 |
| MARIO ERNEST | Director | Mar 07, 2016 | Option Exercise | 8,893 |
| Berrey M Michelle | President and CEO | Mar 01, 2016 | Option Exercise | 46,864 |
| WOLLAEGER TIMOTHY | Director | Mar 01, 2016 | Buy | 46,100 |
| DEMSKI MARTHA J | Director | Mar 01, 2016 | Buy | 48,900 |
| MARIO ERNEST | Director | Feb 08, 2016 | Option Exercise | 8,888 |
| MARIO ERNEST | Director | Jan 13, 2016 | Option Exercise | 8,893 |
| Machado Clarence Patrick | Director | Dec 29, 2015 | Buy | 70,846 |
| MARIO ERNEST | Director | Dec 29, 2015 | Buy | 886,612 |
| MARIO ERNEST | Director | Dec 09, 2015 | Option Exercise | 8,888 |
| MARIO ERNEST | Director | Nov 06, 2015 | Option Exercise | 8,893 |
| DEMSKI MARTHA J | Director | Nov 02, 2015 | Option Exercise | 1,723 |
| DEMSKI MARTHA J | Director | Nov 02, 2015 | Sale | 46,561 |
| MARIO ERNEST | Director | Oct 06, 2015 | Option Exercise | 8,893 |
| DEMSKI MARTHA J | Director | Oct 01, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | Oct 01, 2015 | Sale | 75,368 |
| MARIO ERNEST | Director | Sep 04, 2015 | Option Exercise | 46,453 |
| DEMSKI MARTHA J | Director | Sep 01, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | Sep 01, 2015 | Sale | 96,366 |
| Berrey M Michelle | President and CEO | Aug 26, 2015 | Option Exercise | 52,425 |
| LEONARD JOHN M. | Director | Aug 21, 2015 | Buy | 47,380 |
| Trost Timothy W. | SVP, CFO & Secretary | Aug 12, 2015 | Option Exercise | 99,994 |
| MARIO ERNEST | Director | Aug 06, 2015 | Option Exercise | 75,791 |
| DEMSKI MARTHA J | Director | Aug 03, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | Aug 03, 2015 | Sale | 109,228 |
| Trost Timothy W. | SVP, CFO & Secretary | Jul 17, 2015 | Option Exercise | 65,800 |
| Trost Timothy W. | SVP, CFO & Secretary | Jul 17, 2015 | Sale | 1,400,000 |
| DEMSKI MARTHA J | Director | Jul 01, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | Jul 01, 2015 | Sale | 92,051 |
| MARIO ERNEST | Director | Jun 10, 2015 | Option Exercise | 58,672 |
| DEMSKI MARTHA J | Director | Jun 01, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | Jun 01, 2015 | Sale | 83,164 |
| Ricciardi Lisa | Director | May 12, 2015 | Buy | 75,153 |
| DEMSKI MARTHA J | Director | May 01, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | May 01, 2015 | Sale | 69,420 |
| MARIO ERNEST | Director | Apr 06, 2015 | Option Exercise | 29,362 |
| DEMSKI MARTHA J | Director | Apr 01, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | Apr 01, 2015 | Sale | 73,752 |
| Rogers Michael D. | Chief Development Officer | Mar 23, 2015 | Option Exercise | 48,236 |
| Berrey M Michelle | President and CEO | Mar 20, 2015 | Option Exercise | 136,078 |
| MARIO ERNEST | Director | Mar 18, 2015 | Option Exercise | 58,672 |
| DEMSKI MARTHA J | Director | Mar 02, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | Mar 02, 2015 | Sale | 80,350 |
| DEMSKI MARTHA J | Director | Feb 02, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | Feb 02, 2015 | Sale | 76,769 |
| Berrey M Michelle | President and CEO | Jan 21, 2015 | Option Exercise | 15,626 |
| MARIO ERNEST | Director | Jan 16, 2015 | Option Exercise | 58,672 |
| DEMSKI MARTHA J | Director | Jan 02, 2015 | Option Exercise | 3,060 |
| DEMSKI MARTHA J | Director | Jan 02, 2015 | Sale | 82,154 |
| Berrey M Michelle | President and CEO | Dec 22, 2014 | Option Exercise | 62,503 |
| Trost Timothy W. | Sr. Vice President and CFO | Dec 12, 2014 | Option Exercise | 99,994 |
| MARIO ERNEST | Director | Nov 04, 2014 | Option Exercise | 108,480 |
| MARIO ERNEST | Director | Nov 05, 2014 | Buy | 290,000 |
| LEONARD JOHN M. | Director | Nov 05, 2014 | Buy | 116,000 |
| Trost Timothy W. | Sr. Vice President and CFO | Sep 25, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | Sr. Vice President and CFO | Sep 25, 2014 | Sale | 138,774 |
| Trost Timothy W. | Sr. Vice President and CFO | Aug 25, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | Sr. Vice President and CFO | Aug 25, 2014 | Sale | 125,672 |
| NIEDEL JAMES | Director | Sep 09, 2014 | Sale | 9,436,468 |
| NIEDEL JAMES | Director | Sep 11, 2014 | Sale | 9,722,354 |
| NIEDEL JAMES | Director | Sep 10, 2014 | Sale | 13,172,718 |
| NIEDEL JAMES | Director | Sep 10, 2014 | Option Exercise | 2,916,763 |
| NIEDEL JAMES | Director | Sep 09, 2014 | Option Exercise | 1,458,382 |
| WOLLAEGER TIMOTHY | Director | Sep 09, 2014 | Sale | 3,599,374 |
| Sanderling Venture Partners V, LP | 10% Owner | Sep 09, 2014 | Sale | 3,599,374 |
| Sanderling Venture Partners VI Co Investment Fund LP | 10% Owner | Sep 08, 2014 | Sale | 2,270,632 |
| Sanderling Venture Partners VI Co Investment Fund LP | 10% Owner | Sep 05, 2014 | Sale | 183,027 |
| WOLLAEGER TIMOTHY | Director | Sep 05, 2014 | Sale | 183,027 |
| WOLLAEGER TIMOTHY | Director | Sep 08, 2014 | Sale | 2,270,632 |
| MARIO ERNEST | Director | Sep 05, 2014 | Buy | 231,872 |
| Berrey M Michelle | President and CEO | Sep 02, 2014 | Option Exercise | 62,498 |
| MARIO ERNEST | Director | Aug 26, 2014 | Option Exercise | 44,455 |
| Trost Timothy W. | Sr. Vice President and CFO | Aug 25, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | Sr. Vice President and CFO | Aug 25, 2014 | Sale | 125,672 |
| Trost Timothy W. | See Remarks | Jul 25, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | See Remarks | Jul 28, 2014 | Option Exercise | 6,000 |
| Trost Timothy W. | See Remarks | Jul 25, 2014 | Sale | 111,762 |
| Trost Timothy W. | Sr. Vice President and CFO | Jun 25, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | Sr. Vice President and CFO | Jun 25, 2014 | Sale | 113,697 |
| Berrey M Michelle | See Remarks | May 21, 2014 | Option Exercise | 78,124 |
| MARIO ERNEST | Director | May 27, 2014 | Buy | 142,200 |
| Trost Timothy W. | SVP and CFO | May 27, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | SVP and CFO | May 27, 2014 | Sale | 87,067 |
| Berrey M Michelle | See Remarks | May 27, 2014 | Buy | 200,004 |
| Berrey M Michelle | See Remarks | May 21, 2014 | Option Exercise | 78,086 |
| Trost Timothy W. | See Remarks | Apr 25, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | See Remarks | Apr 25, 2014 | Sale | 93,325 |
| Rogers Michael D. | Chief Development Officer | Apr 25, 2014 | Option Exercise | 98,410 |
| MARIO ERNEST | Director | Apr 01, 2014 | Option Exercise | 35,587 |
| Trost Timothy W. | Sr. VP and CFO | Mar 25, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | Sr. VP and CFO | Mar 25, 2014 | Sale | 126,862 |
| MOCH KENNETH I | President and CEO | Mar 13, 2014 | Option Exercise | 23,550 |
| MOCH KENNETH I | President and CEO | Mar 13, 2014 | Sale | 474,475 |
| MOCH KENNETH I | President and CEO | Feb 24, 2014 | Option Exercise | 14,243 |
| MOCH KENNETH I | President and CEO | Feb 24, 2014 | Sale | 221,440 |
| Trost Timothy W. | Sr. VP & CFO | Feb 25, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | Sr. VP & CFO | Feb 25, 2014 | Sale | 96,470 |
| MOCH KENNETH I | President and CEO | Jan 30, 2014 | Option Exercise | 1,457 |
| MOCH KENNETH I | President and CEO | Jan 30, 2014 | Sale | 18,560 |
| Trost Timothy W. | Sr. Vice President and CFO | Jan 27, 2014 | Option Exercise | 11,750 |
| Trost Timothy W. | Sr. Vice President and CFO | Jan 27, 2014 | Sale | 91,294 |
| Trost Timothy W. | Sr. VP and CFO | Dec 26, 2013 | Option Exercise | 11,750 |
| Trost Timothy W. | Sr. VP and CFO | Dec 26, 2013 | Sale | 76,073 |
| MARIO ERNEST | Director | Dec 13, 2013 | Buy | 69,500 |
| DRAKE RODMAN L | Director | Dec 09, 2013 | Buy | 14,350 |
| Trost Timothy W. | SVP, CFO & Secretary | Nov 25, 2013 | Option Exercise | 11,750 |
| Trost Timothy W. | SVP, CFO & Secretary | Nov 25, 2013 | Sale | 74,934 |
| DRAKE RODMAN L | Director | Nov 25, 2013 | Buy | 15,010 |
| MARIO ERNEST | Director | Nov 25, 2013 | Buy | 121,600 |
| DRAKE RODMAN L | Director | Nov 22, 2013 | Buy | 6,982 |
| DRAKE RODMAN L | Director | Nov 20, 2013 | Buy | 765 |
| MARIO ERNEST | Director | Nov 19, 2013 | Option Exercise | 79,992 |
| MARIO ERNEST | Director | Nov 19, 2013 | Buy | 114,375 |
| DRAKE RODMAN L | Director | Nov 15, 2013 | Buy | 15,557 |
| Trost Timothy W. | SVP, CFO & Secretary | Nov 15, 2013 | Sale | 53,274 |
| MOCH KENNETH I | President and CEO | Nov 15, 2013 | Sale | 39,041 |
| Berrey M Michelle | Chief Medical Officer | Nov 15, 2013 | Option Exercise | 187,500 |
| Trost Timothy W. | Sr. Vice President and CFO | Oct 25, 2013 | Option Exercise | 11,750 |
| Trost Timothy W. | Sr. Vice President and CFO | Oct 25, 2013 | Sale | 80,187 |
| CHAMPSI FARAH | Director | Oct 23, 2013 | Sale | 6,940,710 |
| Hutton Wende S | Director | Oct 23, 2013 | Sale | 10,465,698 |
| PAPPAS ARTHUR M | Director | Oct 23, 2013 | Sale | 3,363,188 |
| Canaan VII L P | Director | Oct 23, 2013 | Sale | 10,465,698 |
| NIEDEL JAMES | Director | Oct 23, 2013 | Sale | 9,082,687 |
| New Leaf Ventures II, L.P. | 10% Owner | Oct 23, 2013 | Sale | 18,165,374 |
| MARIO ERNEST | Director | Aug 29, 2013 | Buy | 66,706 |
| MARIO ERNEST | Director | Aug 30, 2013 | Buy | 13,427 |
| MARIO ERNEST | Director | Aug 26, 2013 | Buy | 102,500 |
| Berrey M Michelle | Chief Medical Officer | Aug 23, 2013 | Buy | 103,598 |
| MARIO ERNEST | Director | Aug 19, 2013 | Buy | 35,000 |
| MARIO ERNEST | Director | Aug 16, 2013 | Buy | 34,900 |
| MARIO ERNEST | Director | Aug 20, 2013 | Buy | 700 |
| Hutton Wende S | Director | Apr 16, 2013 | Option Exercise | 1,537,545 |
| Canaan VII L P | Director | Apr 16, 2013 | Option Exercise | 1,537,545 |