| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Krieg Arthur M | Chief Scientific Officer | Jan 27, 2021 | Buy | $13.05 | 1,701 | 22,198 | 733,191 | Jan 28, 2021, 04:05 PM |
| Krieg Arthur M | Chief Scientific Officer | Jan 19, 2021 | Buy | $13.09 | 500 | 6,545 | 731,490 | Jan 21, 2021, 05:17 PM |
| Chaudhary Kleem | Chief Business Officer | Jan 14, 2021 | Option Exercise | $2.62 | 2,000 | 5,240 | 6,000 | Jan 15, 2021, 04:30 PM |
| Krieg Arthur M | Chief Scientific Officer | Dec 29, 2020 | Buy | $14.16 | 443 | 6,273 | 730,990 | Dec 31, 2020, 04:20 PM |
| Chaudhary Kleem | Chief Business Officer | Dec 22, 2020 | Option Exercise | $2.62 | 4,000 | 10,480 | 4,000 | Dec 23, 2020, 04:15 PM |
| Krieg Arthur M | Chief Scientific Officer | Dec 22, 2020 | Buy | $14.64 | 5,103 | 74,708 | 730,547 | Dec 23, 2020, 04:13 PM |
| Krieg Arthur M | Chief Scientific Officer | Dec 15, 2020 | Buy | $14.49 | 42 | 609 | 720,639 | Dec 17, 2020, 05:21 PM |
| Krieg Arthur M | Chief Scientific Officer | Dec 16, 2020 | Buy | $14.62 | 4,805 | 70,249 | 725,444 | Dec 17, 2020, 05:21 PM |
| Novo Holdings A/S | 10% Owner | Aug 11, 2020 | Buy | $15.00 | 500,000 | 7,500,000 | 2,170,100 | Aug 13, 2020, 04:52 PM |
| POWELL MICHAEL | Director | Aug 11, 2020 | Buy | $15.00 | 133,333 | 1,999,995 | 3,606,707 | Aug 12, 2020, 09:04 PM |
| venBio Global Strategic Fund II L.P. | 10% Owner | Aug 11, 2020 | Buy | $15.00 | 200,000 | 3,000,000 | 3,673,374 | Aug 12, 2020, 09:00 PM |
| Owner | Relationship | Date | Transaction | Value($) |
| Krieg Arthur M | Chief Scientific Officer | Jan 27, 2021 | Buy | 22,198 |
| Krieg Arthur M | Chief Scientific Officer | Jan 19, 2021 | Buy | 6,545 |
| Chaudhary Kleem | Chief Business Officer | Jan 14, 2021 | Option Exercise | 5,240 |
| Krieg Arthur M | Chief Scientific Officer | Dec 29, 2020 | Buy | 6,273 |
| Chaudhary Kleem | Chief Business Officer | Dec 22, 2020 | Option Exercise | 10,480 |
| Krieg Arthur M | Chief Scientific Officer | Dec 22, 2020 | Buy | 74,708 |
| Krieg Arthur M | Chief Scientific Officer | Dec 15, 2020 | Buy | 609 |
| Krieg Arthur M | Chief Scientific Officer | Dec 16, 2020 | Buy | 70,249 |
| Novo Holdings A/S | 10% Owner | Aug 11, 2020 | Buy | 7,500,000 |
| POWELL MICHAEL | Director | Aug 11, 2020 | Buy | 1,999,995 |
| venBio Global Strategic Fund II L.P. | 10% Owner | Aug 11, 2020 | Buy | 3,000,000 |