| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| USMAN NASSIM | President & CEO | Feb 09, 2021 | Buy | $4.81 | 582 | 2,799 | 12,174 | Feb 22, 2021, 09:33 PM |
| Levy Howard | Chief Medical Officer | Feb 09, 2021 | Buy | $4.81 | 1,670 | 8,033 | 23,390 | Feb 22, 2021, 09:33 PM |
| USMAN NASSIM | President & CEO | Aug 10, 2020 | Buy | $4.81 | 582 | 2,799 | 11,592 | Aug 12, 2020, 04:12 PM |
| Levy Howard | Chief Medical Officer | Aug 10, 2020 | Buy | $4.81 | 1,768 | 8,504 | 4,268 | Aug 12, 2020, 04:11 PM |
| Levy Howard | Chief Medical Officer | Mar 16, 2020 | Buy | $4.05 | 2,500 | 10,131 | 2,500 | Mar 17, 2020, 04:23 PM |
| USMAN NASSIM | President & CEO | Mar 13, 2020 | Buy | $3.91 | 4,000 | 15,647 | 11,010 | Mar 13, 2020, 06:56 PM |
| Richard John P | Director | Mar 13, 2020 | Buy | $3.98 | 2,500 | 9,950 | 3,716 | Mar 13, 2020, 06:56 PM |
| Cai Veronica | Controller | Mar 13, 2020 | Buy | $4.11 | 2,000 | 8,220 | 7,353 | Mar 13, 2020, 06:55 PM |
| Williams Eddie | Director | Mar 04, 2020 | Buy | $5.78 | 2,000 | 11,560 | 10,839 | Mar 04, 2020, 12:00 AM |
| Ling Geoffrey M.D. | Director | Feb 25, 2020 | Buy | $6.23 | 3,000 | 18,692 | 3,000 | Feb 27, 2020, 04:06 PM |
| LAWLOR AUGUSTINE | Director | Feb 25, 2020 | Sale | $6.10 | 69,401 | 423,506 | 0 | Feb 25, 2020, 04:21 PM |
| USMAN NASSIM | President & CEO | Feb 10, 2020 | Option Exercise | $6.23 | 430 | 2,679 | 7,010 | Feb 12, 2020, 08:28 PM |
| Levy Howard | Chief Medical Officer | Feb 10, 2020 | Option Exercise | $6.23 | 1,358 | 8,460 | 1,358 | Feb 12, 2020, 08:28 PM |
| Cai Veronica | Controller | Feb 10, 2020 | Option Exercise | $6.23 | 1,678 | 10,454 | 5,353 | Feb 12, 2020, 08:27 PM |
| Payne Fletcher | Chief Financial Officer | Aug 12, 2019 | Option Exercise | $6.51 | 1,180 | 7,682 | 3,744 | Aug 12, 2019, 04:22 PM |
| USMAN NASSIM | President & CEO | Aug 12, 2019 | Option Exercise | $6.51 | 413 | 2,689 | 6,580 | Aug 12, 2019, 04:21 PM |
| Richard John P | Director | May 24, 2019 | Buy | $8.03 | 1,000 | 8,030 | 1,216 | May 28, 2019, 09:45 AM |
| USMAN NASSIM | President & CEO | May 21, 2019 | Option Exercise | $4.63 | 4,400 | 20,372 | 10,567 | May 22, 2019, 02:17 PM |
| Levy Howard | Chief Medical Officer | May 21, 2019 | Option Exercise | $4.63 | 4,400 | 20,372 | 16,094 | May 22, 2019, 12:23 PM |
| Payne Fletcher | Chief Financial Officer | Feb 11, 2019 | Option Exercise | $7.04 | 1,002 | 7,054 | 3,731 | Feb 13, 2019, 07:19 PM |
| USMAN NASSIM | President & CEO | Feb 11, 2019 | Option Exercise | $7.04 | 350 | 2,464 | 6,167 | Feb 13, 2019, 05:01 PM |
| Levy Howard | Chief Medical Officer | Feb 11, 2019 | Option Exercise | $7.04 | 2,485 | 17,494 | 11,867 | Feb 13, 2019, 05:00 PM |
| Levy Howard | Chief Medical Officer | Jan 31, 2019 | Option Exercise | $4.63 | 1,500 | 6,945 | 9,382 | Feb 04, 2019, 04:53 PM |
| Payne Fletcher | Chief Financial Officer | Feb 04, 2019 | Option Exercise | $4.63 | 1,503 | 6,959 | 3,230 | Feb 04, 2019, 04:52 PM |
| USMAN NASSIM | President & CEO | Jan 31, 2019 | Option Exercise | $4.63 | 5,729 | 26,525 | 11,041 | Feb 04, 2019, 04:51 PM |
| Levy Howard | Chief Medical Officer | Nov 26, 2018 | Option Exercise | $4.63 | 149 | 690 | 7,709 | Nov 27, 2018, 05:01 PM |
| Levy Howard | Chief Medical Officer | Nov 16, 2018 | Option Exercise | $4.63 | 173 | 801 | 7,733 | Nov 16, 2018, 05:56 PM |
| Levy Howard | Chief Medical Officer | Nov 16, 2018 | Sale | $11.00 | 173 | 1,903 | 7,560 | Nov 16, 2018, 05:56 PM |
| HILL STEPHEN A | Director | Sep 06, 2018 | Option Exercise | $10.07 | 190 | 1,913 | 1,190 | Sep 06, 2018, 09:41 PM |
| Levy Howard | Chief Medical Officer | May 03, 2018 | Option Exercise | $4.63 | 7,560 | 35,003 | 7,560 | May 04, 2018, 04:58 PM |
| USMAN NASSIM | President & CEO | Apr 04, 2018 | Option Exercise | $4.63 | 88 | 407 | 88 | Apr 06, 2018, 05:03 PM |
| Payne Fletcher | Chief Financial Officer | Mar 26, 2018 | Option Exercise | $4.63 | 59 | 273 | 59 | Mar 28, 2018, 04:11 PM |
| Flynn James E | 10% Owner | Mar 06, 2018 | Sale | $30.87 | 38,042 | 1,174,315 | 849,763 | Mar 21, 2018, 04:12 PM |
| Flynn James E | 10% Owner | Mar 08, 2018 | Sale | $29.15 | 6,756 | 196,967 | 813,147 | Mar 21, 2018, 04:12 PM |
| Flynn James E | 10% Owner | Mar 07, 2018 | Sale | $30.00 | 2,748 | 82,440 | 308,526 | Mar 21, 2018, 04:12 PM |
| Flynn James E | 10% Owner | Mar 07, 2018 | Sale | $30.00 | 7,252 | 217,560 | 814,013 | Mar 21, 2018, 04:12 PM |
| Flynn James E | 10% Owner | Mar 06, 2018 | Sale | $30.87 | 14,419 | 445,099 | 322,076 | Mar 21, 2018, 04:12 PM |
| Flynn James E | 10% Owner | Mar 08, 2018 | Sale | $29.15 | 2,561 | 74,664 | 308,198 | Mar 21, 2018, 04:12 PM |
| Flynn James E | 10% Owner | Mar 08, 2018 | Sale | $29.15 | 9,317 | 271,631 | 1,121,345 | Mar 08, 2018, 05:18 PM |
| Flynn James E | 10% Owner | Mar 07, 2018 | Sale | $30.00 | 10,000 | 300,000 | 1,122,539 | Mar 08, 2018, 05:18 PM |
| Flynn James E | 10% Owner | Mar 06, 2018 | Sale | $30.87 | 52,461 | 1,619,414 | 1,171,839 | Mar 08, 2018, 05:18 PM |
| USMAN NASSIM | President & CEO | Dec 17, 2015 | Buy | $2.00 | 4,000 | 8,000 | 78,375 | Dec 18, 2015, 05:43 PM |
| Payne Fletcher | Chief Financial Officer | Dec 17, 2015 | Buy | $2.00 | 10,000 | 20,000 | 25,032 | Dec 18, 2015, 05:42 PM |
| HILL STEPHEN A | Director | Dec 17, 2015 | Buy | $2.03 | 5,000 | 10,150 | 20,711 | Dec 18, 2015, 05:42 PM |
| HILL STEPHEN A | Director | Aug 28, 2015 | Option Exercise | $6.72 | 12,146 | 81,621 | 15,711 | Aug 31, 2015, 03:55 PM |
| BARRIS PETER J | 10% Owner | Dec 05, 2013 | Sale | $5.13 | 1,000 | 5,131 | 0 | Dec 05, 2013, 03:15 PM |
| SANDELL SCOTT D | 10% Owner | Dec 05, 2013 | Sale | $5.13 | 1,000 | 5,131 | 0 | Dec 05, 2013, 03:15 PM |
| BARRETT M JAMES | 10% Owner | Dec 03, 2013 | Option Exercise | $3.43 | 15,000 | 51,525 | 15,000 | Dec 05, 2013, 03:07 PM |
| BARRETT M JAMES | 10% Owner | Dec 05, 2013 | Sale | $5.13 | 1,000 | 5,131 | 0 | Dec 05, 2013, 03:07 PM |
| BARRETT M JAMES | 10% Owner | Dec 03, 2013 | Sale | $5.38 | 15,000 | 80,754 | 0 | Dec 05, 2013, 03:07 PM |
| BARRIS PETER J | 10% Owner | Nov 21, 2013 | Sale | $5.16 | 5,333 | 27,533 | 1,000 | Nov 22, 2013, 05:10 PM |
| BARRETT M JAMES | 10% Owner | Nov 21, 2013 | Sale | $5.16 | 5,333 | 27,533 | 1,000 | Nov 22, 2013, 05:09 PM |
| SANDELL SCOTT D | 10% Owner | Nov 21, 2013 | Sale | $5.16 | 5,333 | 27,533 | 1,000 | Nov 22, 2013, 05:08 PM |
| BARRIS PETER J | 10% Owner | Jun 03, 2013 | Option Exercise | $0.08 | 1,000 | 75 | 6,333 | Jun 04, 2013, 05:47 PM |
| SANDELL SCOTT D | 10% Owner | Jun 03, 2013 | Option Exercise | $0.08 | 1,000 | 75 | 6,333 | Jun 04, 2013, 05:47 PM |
| BARRETT M JAMES | 10% Owner | Jun 03, 2013 | Option Exercise | $0.08 | 1,000 | 75 | 6,333 | Jun 04, 2013, 05:46 PM |
| BROWN JULIA R | Director | May 10, 2013 | Buy | $5.09 | 6,000 | 30,534 | 6,000 | May 13, 2013, 04:26 PM |
| HILL STEPHEN A | President and CEO | Mar 08, 2013 | Buy | $4.48 | 10,000 | 44,796 | 10,000 | Mar 11, 2013, 04:43 PM |
| HILL STEPHEN A | President and CEO | Mar 11, 2013 | Buy | $4.38 | 10,000 | 43,781 | 20,000 | Mar 11, 2013, 04:43 PM |
| HILL STEPHEN A | President and CEO | Mar 11, 2013 | Buy | $4.38 | 10,000 | 43,781 | 20,000 | Mar 11, 2013, 04:33 PM |
| HILL STEPHEN A | President and CEO | Mar 08, 2013 | Buy | $4.48 | 10,000 | 44,796 | 10,000 | Mar 11, 2013, 04:33 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 16, 2012 | Buy | $4.00 | 595,000 | 2,379,822 | 2,977,919 | Nov 20, 2012, 04:21 PM |
| BARRIS PETER J | 10% Owner | Nov 19, 2012 | Option Exercise | $0.08 | 3,333 | 250 | 5,333 | Nov 20, 2012, 03:51 PM |
| SANDELL SCOTT D | 10% Owner | Nov 19, 2012 | Option Exercise | $0.08 | 3,333 | 250 | 5,333 | Nov 20, 2012, 03:50 PM |
| KRAMLICH C RICHARD | 10% Owner | Nov 19, 2012 | Option Exercise | $0.08 | 3,333 | 250 | 5,333 | Nov 20, 2012, 03:50 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 16, 2012 | Buy | $5.11 | 73,500 | 375,460 | 2,646,619 | Nov 19, 2012, 05:21 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 14, 2012 | Buy | $4.00 | 1,216,712 | 4,866,848 | 2,599,919 | Nov 19, 2012, 05:21 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 08, 2012 | Buy | $4.01 | 49,329 | 197,651 | 1,827,856 | Nov 09, 2012, 04:52 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 07, 2012 | Buy | $4.08 | 23,100 | 94,276 | 1,795,927 | Nov 09, 2012, 04:52 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 02, 2012 | Buy | $4.05 | 57,600 | 233,482 | 1,781,627 | Nov 02, 2012, 06:35 PM |
| BVF PARTNERS L P/IL | 10% Owner | Nov 01, 2012 | Buy | $4.05 | 30,100 | 121,800 | 1,745,527 | Nov 02, 2012, 06:35 PM |
| BVF PARTNERS L P/IL | 10% Owner | Oct 31, 2012 | Buy | $4.06 | 52,000 | 210,896 | 1,738,827 | Nov 02, 2012, 06:35 PM |
| BURRILL STEVEN | Director | Jul 31, 2012 | Option Exercise | $0.08 | 4,333 | 325 | 4,333 | Aug 01, 2012, 05:22 PM |
| Richard John P | Director | Jun 08, 2012 | Buy | $4.16 | 7,500 | 31,192 | 7,500 | Jun 11, 2012, 04:54 PM |
| Bencherif Merouane | SVP, Preclinical Research | May 18, 2012 | Option Exercise | $2.93 | 15,938 | 46,698 | 15,938 | May 22, 2012, 03:10 PM |
| deBethizy J Donald | President and CEO | Feb 14, 2012 | Option Exercise | $5.10 | 798 | 4,070 | 798 | Feb 16, 2012, 05:54 PM |
| Richard John P | Director | Jul 01, 2011 | Option Exercise | $9.27 | 2,500 | 23,175 | 7,833 | Jul 06, 2011, 09:20 AM |
| Richard John P | Director | Jul 01, 2011 | Sale | $21.02 | 2,500 | 52,550 | 5,333 | Jul 06, 2011, 09:20 AM |
| Musso Alan A | SVP, CFO & Treasurer | Jun 07, 2011 | Option Exercise | $5.39 | 30,875 | 166,340 | 33,674 | Jun 08, 2011, 06:31 PM |
| Musso Alan A | SVP, CFO & Treasurer | Jun 07, 2011 | Sale | $21.80 | 30,875 | 672,973 | 2,799 | Jun 08, 2011, 06:31 PM |
| BROWN JULIA R | Director | May 13, 2011 | Option Exercise | $8.70 | 9,100 | 79,170 | 9,100 | May 13, 2011, 07:34 PM |
| BROWN JULIA R | Director | May 13, 2011 | Sale | $23.38 | 9,100 | 212,782 | 0 | May 13, 2011, 07:34 PM |
| BURRILL STEVEN | Director | May 10, 2011 | Option Exercise | $9.37 | 16,948 | 158,803 | 16,948 | May 13, 2011, 07:52 AM |
| BURRILL STEVEN | Director | May 12, 2011 | Option Exercise | $7.32 | 33,052 | 241,972 | 33,052 | May 13, 2011, 07:52 AM |
| BURRILL STEVEN | Director | May 10, 2011 | Sale | $24.04 | 16,948 | 407,471 | 0 | May 13, 2011, 07:52 AM |
| BURRILL STEVEN | Director | May 12, 2011 | Sale | $23.88 | 33,052 | 789,345 | 0 | May 13, 2011, 07:52 AM |
| BURRILL STEVEN | Director | May 10, 2011 | Sale | $24.13 | 2,000 | 48,253 | 0 | May 13, 2011, 07:52 AM |
| BURRILL STEVEN | Director | May 10, 2011 | Option Exercise | $9.37 | 16,948 | 158,803 | 16,948 | May 12, 2011, 06:59 PM |
| BURRILL STEVEN | Director | May 11, 2011 | Option Exercise | $7.32 | 33,052 | 241,972 | 33,052 | May 12, 2011, 06:59 PM |
| BURRILL STEVEN | Director | May 10, 2011 | Sale | $24.13 | 2,000 | 48,253 | 0 | May 12, 2011, 06:59 PM |
| BURRILL STEVEN | Director | May 10, 2011 | Sale | $24.04 | 16,948 | 407,471 | 0 | May 12, 2011, 06:59 PM |
| BURRILL STEVEN | Director | May 11, 2011 | Sale | $23.88 | 33,052 | 789,345 | 0 | May 12, 2011, 06:59 PM |
| Richard John P | Director | Apr 01, 2011 | Option Exercise | $9.27 | 2,500 | 23,175 | 7,833 | Apr 04, 2011, 06:41 PM |
| Richard John P | Director | Apr 01, 2011 | Sale | $26.60 | 2,500 | 66,500 | 5,333 | Apr 04, 2011, 06:41 PM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Mar 31, 2011 | Option Exercise | $2.93 | 2,655 | 7,779 | 10,390 | Apr 04, 2011, 06:34 PM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Mar 31, 2011 | Sale | $26.37 | 2,655 | 70,012 | 7,735 | Apr 04, 2011, 06:34 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 09, 2011 | Option Exercise | $5.55 | 1,500 | 8,325 | 2,659 | Mar 11, 2011, 04:41 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 09, 2011 | Sale | $30.00 | 1,500 | 45,000 | 1,159 | Mar 11, 2011, 04:41 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 07, 2011 | Option Exercise | $5.55 | 500 | 2,775 | 1,659 | Mar 09, 2011, 02:53 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 03, 2011 | Option Exercise | $5.55 | 5,030 | 27,917 | 6,189 | Mar 09, 2011, 02:53 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 03, 2011 | Sale | $30.00 | 5,030 | 150,900 | 1,159 | Mar 09, 2011, 02:53 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 07, 2011 | Sale | $30.00 | 500 | 15,001 | 1,159 | Mar 09, 2011, 02:53 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 02, 2011 | Option Exercise | $5.55 | 200 | 1,110 | 1,359 | Mar 03, 2011, 05:10 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 01, 2011 | Option Exercise | $5.55 | 12,703 | 70,502 | 13,862 | Mar 03, 2011, 05:10 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 01, 2011 | Sale | $30.16 | 12,703 | 383,144 | 1,159 | Mar 03, 2011, 05:10 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 02, 2011 | Sale | $30.00 | 200 | 6,000 | 1,159 | Mar 03, 2011, 05:10 PM |
| Brennan Jeffrey P | SVP - Bus. & Commercial Dev. | Mar 01, 2011 | Option Exercise | $2.93 | 1,264 | 3,704 | 1,264 | Mar 03, 2011, 05:04 PM |
| Brennan Jeffrey P | SVP - Bus. & Commercial Dev. | Mar 01, 2011 | Sale | $30.00 | 1,264 | 37,920 | 0 | Mar 03, 2011, 05:04 PM |
| Hicks Karen A | VP Human Resources | Mar 01, 2011 | Option Exercise | $8.44 | 1,243 | 10,489 | 1,243 | Mar 03, 2011, 05:03 PM |
| Hicks Karen A | VP Human Resources | Mar 01, 2011 | Sale | $30.00 | 1,243 | 37,290 | 0 | Mar 03, 2011, 05:03 PM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Feb 28, 2011 | Option Exercise | $5.55 | 15,481 | 85,920 | 23,216 | Mar 02, 2011, 06:05 PM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Mar 01, 2011 | Option Exercise | $8.51 | 11,360 | 96,674 | 19,095 | Mar 02, 2011, 06:05 PM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Mar 01, 2011 | Sale | $30.00 | 11,360 | 340,800 | 7,735 | Mar 02, 2011, 06:05 PM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Feb 28, 2011 | Sale | $28.00 | 15,481 | 433,468 | 7,735 | Mar 02, 2011, 06:05 PM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Feb 16, 2011 | Option Exercise | $1.75 | 16,655 | 29,146 | 24,390 | Feb 18, 2011, 04:42 PM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Feb 16, 2011 | Sale | $26.52 | 16,655 | 441,656 | 7,735 | Feb 18, 2011, 04:42 PM |
| Richard John P | Director | Jan 19, 2011 | Option Exercise | $2.71 | 5,000 | 13,550 | 10,333 | Jan 20, 2011, 05:45 PM |
| Richard John P | Director | Jan 18, 2011 | Option Exercise | $2.71 | 2,500 | 6,775 | 7,833 | Jan 20, 2011, 05:45 PM |
| Richard John P | Director | Jan 18, 2011 | Sale | $27.38 | 2,500 | 68,440 | 5,333 | Jan 20, 2011, 05:45 PM |
| Richard John P | Director | Jan 19, 2011 | Sale | $27.11 | 5,000 | 135,542 | 5,333 | Jan 20, 2011, 05:45 PM |
| Bencherif Merouane | SVP, Preclinical Research | Jan 18, 2011 | Option Exercise | $5.55 | 22,800 | 126,540 | 22,800 | Jan 20, 2011, 05:40 PM |
| Bencherif Merouane | SVP, Preclinical Research | Jan 19, 2011 | Option Exercise | $2.75 | 30,203 | 83,069 | 30,203 | Jan 20, 2011, 05:40 PM |
| Bencherif Merouane | SVP, Preclinical Research | Jan 19, 2011 | Sale | $27.09 | 30,203 | 818,257 | 0 | Jan 20, 2011, 05:40 PM |
| Bencherif Merouane | SVP, Preclinical Research | Jan 18, 2011 | Sale | $27.17 | 22,800 | 619,476 | 0 | Jan 20, 2011, 05:40 PM |
| Hicks Karen A | VP Human Resources | Jan 14, 2011 | Option Exercise | $2.93 | 1,719 | 5,037 | 1,719 | Jan 18, 2011, 06:34 AM |
| Hicks Karen A | VP Human Resources | Jan 13, 2011 | Option Exercise | $2.93 | 3,369 | 9,871 | 3,369 | Jan 18, 2011, 06:34 AM |
| Hicks Karen A | VP Human Resources | Jan 13, 2011 | Sale | $27.24 | 3,369 | 91,760 | 0 | Jan 18, 2011, 06:34 AM |
| Hicks Karen A | VP Human Resources | Jan 14, 2011 | Sale | $27.50 | 1,719 | 47,273 | 0 | Jan 18, 2011, 06:34 AM |
| Hicks Karen A | VP Human Resources | Jan 12, 2011 | Option Exercise | $5.91 | 11,231 | 66,420 | 11,231 | Jan 13, 2011, 06:55 PM |
| Hicks Karen A | VP Human Resources | Jan 11, 2011 | Option Exercise | $6.26 | 13,825 | 86,479 | 13,825 | Jan 13, 2011, 06:55 PM |
| Hicks Karen A | VP Human Resources | Jan 11, 2011 | Sale | $27.02 | 13,825 | 373,571 | 0 | Jan 13, 2011, 06:55 PM |
| Hicks Karen A | VP Human Resources | Jan 12, 2011 | Sale | $27.18 | 11,231 | 305,298 | 0 | Jan 13, 2011, 06:55 PM |
| Musso Alan A | SVP, CFO & Treasurer | Dec 22, 2010 | Option Exercise | $5.10 | 4,881 | 24,893 | 7,680 | Dec 23, 2010, 10:11 AM |
| Musso Alan A | SVP, CFO & Treasurer | Dec 21, 2010 | Option Exercise | $5.10 | 15,535 | 79,228 | 18,334 | Dec 23, 2010, 10:11 AM |
| Musso Alan A | SVP, CFO & Treasurer | Dec 21, 2010 | Sale | $26.61 | 15,535 | 413,386 | 2,799 | Dec 23, 2010, 10:11 AM |
| Musso Alan A | SVP, CFO & Treasurer | Dec 22, 2010 | Sale | $26.47 | 4,881 | 129,200 | 2,799 | Dec 23, 2010, 10:11 AM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 20, 2010 | Option Exercise | $1.75 | 8,882 | 15,544 | 10,035 | Dec 21, 2010, 01:46 PM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 17, 2010 | Option Exercise | $1.75 | 2,100 | 3,675 | 3,253 | Dec 21, 2010, 01:46 PM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 17, 2010 | Sale | $26.08 | 2,100 | 54,765 | 1,153 | Dec 21, 2010, 01:46 PM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 20, 2010 | Sale | $26.02 | 8,882 | 231,120 | 1,153 | Dec 21, 2010, 01:46 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Dec 16, 2010 | Option Exercise | $8.51 | 2,700 | 22,977 | 3,859 | Dec 20, 2010, 11:48 AM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Dec 16, 2010 | Sale | $25.24 | 2,700 | 68,142 | 1,159 | Dec 20, 2010, 11:48 AM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 16, 2010 | Option Exercise | $1.75 | 200 | 350 | 1,353 | Dec 20, 2010, 11:47 AM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 16, 2010 | Sale | $25.15 | 200 | 5,030 | 1,153 | Dec 20, 2010, 11:47 AM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Dec 13, 2010 | Option Exercise | $1.75 | 12,000 | 21,000 | 19,735 | Dec 14, 2010, 05:24 PM |
| Caldwell William S | SVP - Drug Discovery and Dev. | Dec 13, 2010 | Sale | $23.95 | 12,000 | 287,377 | 7,735 | Dec 14, 2010, 05:24 PM |
| Brennan Jeffrey P | SVP - Bus. & Commercial Dev. | Dec 13, 2010 | Option Exercise | $2.93 | 10,000 | 29,300 | 10,000 | Dec 14, 2010, 05:23 PM |
| Brennan Jeffrey P | SVP - Bus. & Commercial Dev. | Dec 13, 2010 | Sale | $23.86 | 10,000 | 238,553 | 0 | Dec 14, 2010, 05:23 PM |
| Bencherif Merouane | SVP, Preclinical Research | Dec 10, 2010 | Option Exercise | $6.00 | 32,093 | 192,535 | 32,093 | Dec 14, 2010, 05:22 PM |
| Bencherif Merouane | SVP, Preclinical Research | Dec 10, 2010 | Sale | $24.05 | 32,093 | 771,955 | 0 | Dec 14, 2010, 05:22 PM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 08, 2010 | Option Exercise | $5.10 | 11,250 | 57,375 | 12,403 | Dec 10, 2010, 05:43 PM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 08, 2010 | Sale | $22.68 | 11,250 | 255,150 | 1,153 | Dec 10, 2010, 05:43 PM |
| SKALETSKY MARK B | Director | Nov 17, 2010 | Option Exercise | $7.23 | 29,500 | 213,145 | 40,832 | Nov 18, 2010, 05:23 PM |
| SKALETSKY MARK B | Director | Nov 16, 2010 | Option Exercise | $2.71 | 3,000 | 8,130 | 14,332 | Nov 18, 2010, 05:23 PM |
| SKALETSKY MARK B | Director | Nov 16, 2010 | Sale | $21.76 | 3,000 | 65,295 | 11,332 | Nov 18, 2010, 05:23 PM |
| SKALETSKY MARK B | Director | Nov 17, 2010 | Sale | $22.00 | 29,500 | 649,000 | 11,332 | Nov 18, 2010, 05:23 PM |
| BLIXT CHARLES A | Director | Nov 17, 2010 | Option Exercise | $9.27 | 5,500 | 50,985 | 5,500 | Nov 18, 2010, 05:14 PM |
| BLIXT CHARLES A | Director | Nov 16, 2010 | Option Exercise | $7.56 | 9,500 | 71,790 | 9,500 | Nov 18, 2010, 05:14 PM |
| BLIXT CHARLES A | Director | Nov 16, 2010 | Sale | $21.80 | 9,500 | 207,067 | 0 | Nov 18, 2010, 05:14 PM |
| BLIXT CHARLES A | Director | Nov 17, 2010 | Sale | $21.76 | 5,500 | 119,666 | 0 | Nov 18, 2010, 05:14 PM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 05, 2010 | Option Exercise | $1.75 | 700 | 1,225 | 1,853 | Nov 09, 2010, 06:43 PM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 05, 2010 | Sale | $25.02 | 700 | 17,512 | 1,153 | Nov 09, 2010, 06:43 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 05, 2010 | Option Exercise | $8.51 | 1,400 | 11,914 | 2,559 | Nov 09, 2010, 06:39 PM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 05, 2010 | Sale | $25.01 | 1,400 | 35,014 | 1,159 | Nov 09, 2010, 06:39 PM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 04, 2010 | Option Exercise | $1.75 | 7,784 | 13,622 | 8,937 | Nov 05, 2010, 11:27 AM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 03, 2010 | Option Exercise | $1.75 | 986 | 1,726 | 2,139 | Nov 05, 2010, 11:27 AM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 03, 2010 | Sale | $25.05 | 986 | 24,699 | 1,153 | Nov 05, 2010, 11:27 AM |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 04, 2010 | Sale | $25.07 | 7,784 | 195,139 | 1,153 | Nov 05, 2010, 11:27 AM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 04, 2010 | Option Exercise | $8.51 | 7,800 | 66,378 | 8,959 | Nov 05, 2010, 11:25 AM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 03, 2010 | Option Exercise | $8.51 | 1,000 | 8,510 | 2,159 | Nov 05, 2010, 11:25 AM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 03, 2010 | Sale | $25.06 | 1,000 | 25,055 | 1,159 | Nov 05, 2010, 11:25 AM |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 04, 2010 | Sale | $25.08 | 7,800 | 195,605 | 1,159 | Nov 05, 2010, 11:25 AM |
| Musso Alan A | SVP, CFO & Treasurer | Oct 28, 2010 | Option Exercise | $2.93 | 1,500 | 4,395 | 4,299 | Oct 28, 2010, 05:32 PM |
| Musso Alan A | SVP, CFO & Treasurer | Oct 26, 2010 | Option Exercise | $2.93 | 2,000 | 5,860 | 4,799 | Oct 28, 2010, 05:32 PM |
| Musso Alan A | SVP, CFO & Treasurer | Oct 26, 2010 | Sale | $24.65 | 2,000 | 49,295 | 2,799 | Oct 28, 2010, 05:32 PM |
| Musso Alan A | SVP, CFO & Treasurer | Oct 28, 2010 | Sale | $24.60 | 1,500 | 36,900 | 2,799 | Oct 28, 2010, 05:32 PM |
| Musso Alan A | SVP, CFO & Treasurer | Oct 25, 2010 | Option Exercise | $2.93 | 8,500 | 24,905 | 11,299 | Oct 26, 2010, 04:44 PM |
| Musso Alan A | SVP, CFO & Treasurer | Oct 22, 2010 | Option Exercise | $2.93 | 600 | 1,758 | 3,399 | Oct 26, 2010, 04:44 PM |
| Musso Alan A | SVP, CFO & Treasurer | Oct 22, 2010 | Sale | $24.60 | 600 | 14,760 | 2,799 | Oct 26, 2010, 04:44 PM |
| Musso Alan A | SVP, CFO & Treasurer | Oct 25, 2010 | Sale | $24.69 | 8,500 | 209,892 | 2,799 | Oct 26, 2010, 04:44 PM |
| DUNTON ALAN W | Director | Aug 02, 2010 | Option Exercise | $5.69 | 6,000 | 34,140 | 6,000 | Aug 03, 2010, 08:07 PM |
| DUNTON ALAN W | Director | Aug 02, 2010 | Sale | $22.30 | 6,000 | 133,791 | 0 | Aug 03, 2010, 08:07 PM |
| DUNTON ALAN W | Director | Jul 23, 2010 | Option Exercise | $5.69 | 2,336 | 13,292 | 2,336 | Jul 27, 2010, 07:01 PM |
| DUNTON ALAN W | Director | Jul 26, 2010 | Option Exercise | $5.69 | 2,864 | 16,296 | 2,864 | Jul 27, 2010, 07:01 PM |
| DUNTON ALAN W | Director | Jul 26, 2010 | Sale | $21.12 | 2,864 | 60,476 | 0 | Jul 27, 2010, 07:01 PM |
| DUNTON ALAN W | Director | Jul 23, 2010 | Sale | $21.00 | 2,336 | 49,063 | 0 | Jul 27, 2010, 07:01 PM |
| Owner | Relationship | Date | Transaction | Value($) |
| USMAN NASSIM | President & CEO | Feb 09, 2021 | Buy | 2,799 |
| Levy Howard | Chief Medical Officer | Feb 09, 2021 | Buy | 8,033 |
| USMAN NASSIM | President & CEO | Aug 10, 2020 | Buy | 2,799 |
| Levy Howard | Chief Medical Officer | Aug 10, 2020 | Buy | 8,504 |
| Levy Howard | Chief Medical Officer | Mar 16, 2020 | Buy | 10,131 |
| USMAN NASSIM | President & CEO | Mar 13, 2020 | Buy | 15,647 |
| Richard John P | Director | Mar 13, 2020 | Buy | 9,950 |
| Cai Veronica | Controller | Mar 13, 2020 | Buy | 8,220 |
| Williams Eddie | Director | Mar 04, 2020 | Buy | 11,560 |
| Ling Geoffrey M.D. | Director | Feb 25, 2020 | Buy | 18,692 |
| LAWLOR AUGUSTINE | Director | Feb 25, 2020 | Sale | 423,506 |
| USMAN NASSIM | President & CEO | Feb 10, 2020 | Option Exercise | 2,679 |
| Levy Howard | Chief Medical Officer | Feb 10, 2020 | Option Exercise | 8,460 |
| Cai Veronica | Controller | Feb 10, 2020 | Option Exercise | 10,454 |
| Payne Fletcher | Chief Financial Officer | Aug 12, 2019 | Option Exercise | 7,682 |
| USMAN NASSIM | President & CEO | Aug 12, 2019 | Option Exercise | 2,689 |
| Richard John P | Director | May 24, 2019 | Buy | 8,030 |
| USMAN NASSIM | President & CEO | May 21, 2019 | Option Exercise | 20,372 |
| Levy Howard | Chief Medical Officer | May 21, 2019 | Option Exercise | 20,372 |
| Payne Fletcher | Chief Financial Officer | Feb 11, 2019 | Option Exercise | 7,054 |
| USMAN NASSIM | President & CEO | Feb 11, 2019 | Option Exercise | 2,464 |
| Levy Howard | Chief Medical Officer | Feb 11, 2019 | Option Exercise | 17,494 |
| Levy Howard | Chief Medical Officer | Jan 31, 2019 | Option Exercise | 6,945 |
| Payne Fletcher | Chief Financial Officer | Feb 04, 2019 | Option Exercise | 6,959 |
| USMAN NASSIM | President & CEO | Jan 31, 2019 | Option Exercise | 26,525 |
| Levy Howard | Chief Medical Officer | Nov 26, 2018 | Option Exercise | 690 |
| Levy Howard | Chief Medical Officer | Nov 16, 2018 | Option Exercise | 801 |
| Levy Howard | Chief Medical Officer | Nov 16, 2018 | Sale | 1,903 |
| HILL STEPHEN A | Director | Sep 06, 2018 | Option Exercise | 1,913 |
| Levy Howard | Chief Medical Officer | May 03, 2018 | Option Exercise | 35,003 |
| USMAN NASSIM | President & CEO | Apr 04, 2018 | Option Exercise | 407 |
| Payne Fletcher | Chief Financial Officer | Mar 26, 2018 | Option Exercise | 273 |
| Flynn James E | 10% Owner | Mar 06, 2018 | Sale | 1,174,315 |
| Flynn James E | 10% Owner | Mar 08, 2018 | Sale | 196,967 |
| Flynn James E | 10% Owner | Mar 07, 2018 | Sale | 82,440 |
| Flynn James E | 10% Owner | Mar 07, 2018 | Sale | 217,560 |
| Flynn James E | 10% Owner | Mar 06, 2018 | Sale | 445,099 |
| Flynn James E | 10% Owner | Mar 08, 2018 | Sale | 74,664 |
| Flynn James E | 10% Owner | Mar 08, 2018 | Sale | 271,631 |
| Flynn James E | 10% Owner | Mar 07, 2018 | Sale | 300,000 |
| Flynn James E | 10% Owner | Mar 06, 2018 | Sale | 1,619,414 |
| USMAN NASSIM | President & CEO | Dec 17, 2015 | Buy | 8,000 |
| Payne Fletcher | Chief Financial Officer | Dec 17, 2015 | Buy | 20,000 |
| HILL STEPHEN A | Director | Dec 17, 2015 | Buy | 10,150 |
| HILL STEPHEN A | Director | Aug 28, 2015 | Option Exercise | 81,621 |
| BARRIS PETER J | 10% Owner | Dec 05, 2013 | Sale | 5,131 |
| SANDELL SCOTT D | 10% Owner | Dec 05, 2013 | Sale | 5,131 |
| BARRETT M JAMES | 10% Owner | Dec 03, 2013 | Option Exercise | 51,525 |
| BARRETT M JAMES | 10% Owner | Dec 05, 2013 | Sale | 5,131 |
| BARRETT M JAMES | 10% Owner | Dec 03, 2013 | Sale | 80,754 |
| BARRIS PETER J | 10% Owner | Nov 21, 2013 | Sale | 27,533 |
| BARRETT M JAMES | 10% Owner | Nov 21, 2013 | Sale | 27,533 |
| SANDELL SCOTT D | 10% Owner | Nov 21, 2013 | Sale | 27,533 |
| BARRIS PETER J | 10% Owner | Jun 03, 2013 | Option Exercise | 75 |
| SANDELL SCOTT D | 10% Owner | Jun 03, 2013 | Option Exercise | 75 |
| BARRETT M JAMES | 10% Owner | Jun 03, 2013 | Option Exercise | 75 |
| BROWN JULIA R | Director | May 10, 2013 | Buy | 30,534 |
| HILL STEPHEN A | President and CEO | Mar 08, 2013 | Buy | 44,796 |
| HILL STEPHEN A | President and CEO | Mar 11, 2013 | Buy | 43,781 |
| HILL STEPHEN A | President and CEO | Mar 11, 2013 | Buy | 43,781 |
| HILL STEPHEN A | President and CEO | Mar 08, 2013 | Buy | 44,796 |
| BVF PARTNERS L P/IL | 10% Owner | Nov 16, 2012 | Buy | 2,379,822 |
| BARRIS PETER J | 10% Owner | Nov 19, 2012 | Option Exercise | 250 |
| SANDELL SCOTT D | 10% Owner | Nov 19, 2012 | Option Exercise | 250 |
| KRAMLICH C RICHARD | 10% Owner | Nov 19, 2012 | Option Exercise | 250 |
| BVF PARTNERS L P/IL | 10% Owner | Nov 16, 2012 | Buy | 375,460 |
| BVF PARTNERS L P/IL | 10% Owner | Nov 14, 2012 | Buy | 4,866,848 |
| BVF PARTNERS L P/IL | 10% Owner | Nov 08, 2012 | Buy | 197,651 |
| BVF PARTNERS L P/IL | 10% Owner | Nov 07, 2012 | Buy | 94,276 |
| BVF PARTNERS L P/IL | 10% Owner | Nov 02, 2012 | Buy | 233,482 |
| BVF PARTNERS L P/IL | 10% Owner | Nov 01, 2012 | Buy | 121,800 |
| BVF PARTNERS L P/IL | 10% Owner | Oct 31, 2012 | Buy | 210,896 |
| BURRILL STEVEN | Director | Jul 31, 2012 | Option Exercise | 325 |
| Richard John P | Director | Jun 08, 2012 | Buy | 31,192 |
| Bencherif Merouane | SVP, Preclinical Research | May 18, 2012 | Option Exercise | 46,698 |
| deBethizy J Donald | President and CEO | Feb 14, 2012 | Option Exercise | 4,070 |
| Richard John P | Director | Jul 01, 2011 | Option Exercise | 23,175 |
| Richard John P | Director | Jul 01, 2011 | Sale | 52,550 |
| Musso Alan A | SVP, CFO & Treasurer | Jun 07, 2011 | Option Exercise | 166,340 |
| Musso Alan A | SVP, CFO & Treasurer | Jun 07, 2011 | Sale | 672,973 |
| BROWN JULIA R | Director | May 13, 2011 | Option Exercise | 79,170 |
| BROWN JULIA R | Director | May 13, 2011 | Sale | 212,782 |
| BURRILL STEVEN | Director | May 10, 2011 | Option Exercise | 158,803 |
| BURRILL STEVEN | Director | May 12, 2011 | Option Exercise | 241,972 |
| BURRILL STEVEN | Director | May 10, 2011 | Sale | 407,471 |
| BURRILL STEVEN | Director | May 12, 2011 | Sale | 789,345 |
| BURRILL STEVEN | Director | May 10, 2011 | Sale | 48,253 |
| BURRILL STEVEN | Director | May 10, 2011 | Option Exercise | 158,803 |
| BURRILL STEVEN | Director | May 11, 2011 | Option Exercise | 241,972 |
| BURRILL STEVEN | Director | May 10, 2011 | Sale | 48,253 |
| BURRILL STEVEN | Director | May 10, 2011 | Sale | 407,471 |
| BURRILL STEVEN | Director | May 11, 2011 | Sale | 789,345 |
| Richard John P | Director | Apr 01, 2011 | Option Exercise | 23,175 |
| Richard John P | Director | Apr 01, 2011 | Sale | 66,500 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Mar 31, 2011 | Option Exercise | 7,779 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Mar 31, 2011 | Sale | 70,012 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 09, 2011 | Option Exercise | 8,325 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 09, 2011 | Sale | 45,000 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 07, 2011 | Option Exercise | 2,775 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 03, 2011 | Option Exercise | 27,917 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 03, 2011 | Sale | 150,900 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 07, 2011 | Sale | 15,001 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 02, 2011 | Option Exercise | 1,110 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 01, 2011 | Option Exercise | 70,502 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 01, 2011 | Sale | 383,144 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Mar 02, 2011 | Sale | 6,000 |
| Brennan Jeffrey P | SVP - Bus. & Commercial Dev. | Mar 01, 2011 | Option Exercise | 3,704 |
| Brennan Jeffrey P | SVP - Bus. & Commercial Dev. | Mar 01, 2011 | Sale | 37,920 |
| Hicks Karen A | VP Human Resources | Mar 01, 2011 | Option Exercise | 10,489 |
| Hicks Karen A | VP Human Resources | Mar 01, 2011 | Sale | 37,290 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Feb 28, 2011 | Option Exercise | 85,920 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Mar 01, 2011 | Option Exercise | 96,674 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Mar 01, 2011 | Sale | 340,800 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Feb 28, 2011 | Sale | 433,468 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Feb 16, 2011 | Option Exercise | 29,146 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Feb 16, 2011 | Sale | 441,656 |
| Richard John P | Director | Jan 19, 2011 | Option Exercise | 13,550 |
| Richard John P | Director | Jan 18, 2011 | Option Exercise | 6,775 |
| Richard John P | Director | Jan 18, 2011 | Sale | 68,440 |
| Richard John P | Director | Jan 19, 2011 | Sale | 135,542 |
| Bencherif Merouane | SVP, Preclinical Research | Jan 18, 2011 | Option Exercise | 126,540 |
| Bencherif Merouane | SVP, Preclinical Research | Jan 19, 2011 | Option Exercise | 83,069 |
| Bencherif Merouane | SVP, Preclinical Research | Jan 19, 2011 | Sale | 818,257 |
| Bencherif Merouane | SVP, Preclinical Research | Jan 18, 2011 | Sale | 619,476 |
| Hicks Karen A | VP Human Resources | Jan 14, 2011 | Option Exercise | 5,037 |
| Hicks Karen A | VP Human Resources | Jan 13, 2011 | Option Exercise | 9,871 |
| Hicks Karen A | VP Human Resources | Jan 13, 2011 | Sale | 91,760 |
| Hicks Karen A | VP Human Resources | Jan 14, 2011 | Sale | 47,273 |
| Hicks Karen A | VP Human Resources | Jan 12, 2011 | Option Exercise | 66,420 |
| Hicks Karen A | VP Human Resources | Jan 11, 2011 | Option Exercise | 86,479 |
| Hicks Karen A | VP Human Resources | Jan 11, 2011 | Sale | 373,571 |
| Hicks Karen A | VP Human Resources | Jan 12, 2011 | Sale | 305,298 |
| Musso Alan A | SVP, CFO & Treasurer | Dec 22, 2010 | Option Exercise | 24,893 |
| Musso Alan A | SVP, CFO & Treasurer | Dec 21, 2010 | Option Exercise | 79,228 |
| Musso Alan A | SVP, CFO & Treasurer | Dec 21, 2010 | Sale | 413,386 |
| Musso Alan A | SVP, CFO & Treasurer | Dec 22, 2010 | Sale | 129,200 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 20, 2010 | Option Exercise | 15,544 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 17, 2010 | Option Exercise | 3,675 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 17, 2010 | Sale | 54,765 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 20, 2010 | Sale | 231,120 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Dec 16, 2010 | Option Exercise | 22,977 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Dec 16, 2010 | Sale | 68,142 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 16, 2010 | Option Exercise | 350 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 16, 2010 | Sale | 5,030 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Dec 13, 2010 | Option Exercise | 21,000 |
| Caldwell William S | SVP - Drug Discovery and Dev. | Dec 13, 2010 | Sale | 287,377 |
| Brennan Jeffrey P | SVP - Bus. & Commercial Dev. | Dec 13, 2010 | Option Exercise | 29,300 |
| Brennan Jeffrey P | SVP - Bus. & Commercial Dev. | Dec 13, 2010 | Sale | 238,553 |
| Bencherif Merouane | SVP, Preclinical Research | Dec 10, 2010 | Option Exercise | 192,535 |
| Bencherif Merouane | SVP, Preclinical Research | Dec 10, 2010 | Sale | 771,955 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 08, 2010 | Option Exercise | 57,375 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Dec 08, 2010 | Sale | 255,150 |
| SKALETSKY MARK B | Director | Nov 17, 2010 | Option Exercise | 213,145 |
| SKALETSKY MARK B | Director | Nov 16, 2010 | Option Exercise | 8,130 |
| SKALETSKY MARK B | Director | Nov 16, 2010 | Sale | 65,295 |
| SKALETSKY MARK B | Director | Nov 17, 2010 | Sale | 649,000 |
| BLIXT CHARLES A | Director | Nov 17, 2010 | Option Exercise | 50,985 |
| BLIXT CHARLES A | Director | Nov 16, 2010 | Option Exercise | 71,790 |
| BLIXT CHARLES A | Director | Nov 16, 2010 | Sale | 207,067 |
| BLIXT CHARLES A | Director | Nov 17, 2010 | Sale | 119,666 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 05, 2010 | Option Exercise | 1,225 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 05, 2010 | Sale | 17,512 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 05, 2010 | Option Exercise | 11,914 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 05, 2010 | Sale | 35,014 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 04, 2010 | Option Exercise | 13,622 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 03, 2010 | Option Exercise | 1,726 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 03, 2010 | Sale | 24,699 |
| Dunbar Geoffrey C | SVP, Clin. Dev. & Reg. Affairs | Nov 04, 2010 | Sale | 195,139 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 04, 2010 | Option Exercise | 66,378 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 03, 2010 | Option Exercise | 8,510 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 03, 2010 | Sale | 25,055 |
| Hodges Mauri K | VP Fin + Corp Sys & Controller | Nov 04, 2010 | Sale | 195,605 |
| Musso Alan A | SVP, CFO & Treasurer | Oct 28, 2010 | Option Exercise | 4,395 |
| Musso Alan A | SVP, CFO & Treasurer | Oct 26, 2010 | Option Exercise | 5,860 |
| Musso Alan A | SVP, CFO & Treasurer | Oct 26, 2010 | Sale | 49,295 |
| Musso Alan A | SVP, CFO & Treasurer | Oct 28, 2010 | Sale | 36,900 |
| Musso Alan A | SVP, CFO & Treasurer | Oct 25, 2010 | Option Exercise | 24,905 |
| Musso Alan A | SVP, CFO & Treasurer | Oct 22, 2010 | Option Exercise | 1,758 |
| Musso Alan A | SVP, CFO & Treasurer | Oct 22, 2010 | Sale | 14,760 |
| Musso Alan A | SVP, CFO & Treasurer | Oct 25, 2010 | Sale | 209,892 |
| DUNTON ALAN W | Director | Aug 02, 2010 | Option Exercise | 34,140 |
| DUNTON ALAN W | Director | Aug 02, 2010 | Sale | 133,791 |
| DUNTON ALAN W | Director | Jul 23, 2010 | Option Exercise | 13,292 |
| DUNTON ALAN W | Director | Jul 26, 2010 | Option Exercise | 16,296 |
| DUNTON ALAN W | Director | Jul 26, 2010 | Sale | 60,476 |
| DUNTON ALAN W | Director | Jul 23, 2010 | Sale | 49,063 |