| Owner | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| Vounatsos Michel | Chief Executive Officer | May 02, 2019 | Option Exercise | $230.52 | 658 | 151,682 | 21,829 | May 06, 2019, 04:20 PM |
| DENNER ALEXANDER J | Director | Apr 30, 2019 | Buy | $229.25 | 50,342 | 11,540,904 | 575,000 | May 02, 2019, 05:06 PM |
| DENNER ALEXANDER J | Director | May 02, 2019 | Buy | $231.24 | 38,000 | 8,787,120 | 643,000 | May 02, 2019, 05:06 PM |
| DENNER ALEXANDER J | Director | May 01, 2019 | Buy | $229.46 | 30,000 | 6,883,800 | 605,000 | May 02, 2019, 05:06 PM |
| Vounatsos Michel | Chief Executive Officer | May 01, 2019 | Buy | $231.48 | 4,351 | 1,007,169 | 21,007 | May 02, 2019, 04:30 PM |
| PANGIA ROBERT W | Director | Mar 18, 2019 | Option Exercise | $52.22 | 6,114 | 319,273 | 24,701 | Mar 19, 2019, 04:08 PM |
| PANGIA ROBERT W | Director | Mar 18, 2019 | Sale | $328.55 | 6,114 | 2,008,755 | 18,587 | Mar 19, 2019, 04:08 PM |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Mar 01, 2019 | Option Exercise | $334.10 | 658 | 219,838 | 7,235 | Mar 05, 2019, 12:00 AM |
| ALEXANDER SUSAN H | EVP Chief Legal Officer & Sec. | Feb 22, 2019 | Option Exercise | $325.33 | 4,109 | 1,336,781 | 32,715 | Feb 26, 2019, 05:09 PM |
| ALEXANDER SUSAN H | EVP Chief Legal Officer & Sec. | Feb 22, 2019 | Option Exercise | $48.52 | 6,395 | 310,285 | 36,085 | Feb 26, 2019, 05:09 PM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 22, 2019 | Option Exercise | $325.33 | 739 | 240,419 | 10,409 | Feb 26, 2019, 05:07 PM |
| Vounatsos Michel | Chief Executive Officer | Feb 15, 2019 | Option Exercise | $332.87 | 2,340 | 778,916 | 16,574 | Feb 20, 2019, 06:10 PM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 15, 2019 | Option Exercise | $332.87 | 586 | 195,062 | 9,485 | Feb 20, 2019, 06:08 PM |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Feb 15, 2019 | Option Exercise | $332.87 | 643 | 214,035 | 7,325 | Feb 20, 2019, 06:07 PM |
| Ehlers Michael D | EVP, Research and Development | Feb 15, 2019 | Option Exercise | $332.87 | 749 | 249,320 | 7,777 | Feb 20, 2019, 05:54 PM |
| ALEXANDER SUSAN H | EVP Chief Legal Officer & Sec. | Feb 15, 2019 | Option Exercise | $332.87 | 749 | 249,320 | 28,027 | Feb 20, 2019, 05:53 PM |
| Vounatsos Michel | Chief Executive Officer | Feb 12, 2019 | Option Exercise | $319.43 | 2,622 | 837,545 | 13,645 | Feb 14, 2019, 06:33 PM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 12, 2019 | Option Exercise | $319.43 | 2,518 | 804,325 | 8,753 | Feb 14, 2019, 06:29 PM |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Feb 12, 2019 | Option Exercise | $319.43 | 919 | 293,556 | 6,520 | Feb 14, 2019, 06:17 PM |
| Gregory Ginger | EVP, Human Resources | Feb 12, 2019 | Option Exercise | $319.43 | 551 | 176,006 | 2,244 | Feb 14, 2019, 06:10 PM |
| Ehlers Michael D | EVP, Research and Development | Feb 12, 2019 | Option Exercise | $319.43 | 1,267 | 404,718 | 6,841 | Feb 14, 2019, 06:07 PM |
| ALEXANDER SUSAN H | EVP Chief Legal Officer & Sec. | Feb 12, 2019 | Option Exercise | $319.43 | 1,021 | 326,138 | 27,091 | Feb 14, 2019, 06:04 PM |
| DENNER ALEXANDER J | Director | Jan 31, 2019 | Buy | $330.52 | 25,800 | 8,527,393 | 517,658 | Feb 01, 2019, 04:19 PM |
| DENNER ALEXANDER J | Director | Jan 30, 2019 | Buy | $324.86 | 30,000 | 9,745,851 | 491,858 | Feb 01, 2019, 04:19 PM |
| DENNER ALEXANDER J | Director | Feb 01, 2019 | Buy | $328.45 | 7,000 | 2,299,163 | 524,658 | Feb 01, 2019, 04:19 PM |
| CAPELLO JEFFREY D | EVP & Chief Financial Officer | Jan 02, 2019 | Option Exercise | $304.69 | 414 | 126,142 | 917 | Jan 04, 2019, 04:17 PM |
| Guindo Chirfi | EVP Glob. Mkt Acc & Cust Innov | Dec 01, 2018 | Option Exercise | $333.72 | 409 | 136,491 | 2,543 | Dec 04, 2018, 08:21 PM |
| Ehlers Michael D | EVP, Research and Development | Sep 26, 2018 | Sale | $350.00 | 1,000 | 350,000 | 4,281 | Sep 27, 2018, 04:16 PM |
| Gregory Ginger | EVP, Human Resources | Aug 01, 2018 | Option Exercise | $344.06 | 163 | 56,082 | 1,044 | Aug 03, 2018, 04:14 PM |
| Ehlers Michael D | EVP, Research and Development | Jun 01, 2018 | Option Exercise | $297.09 | 1,076 | 319,669 | 5,281 | Jun 05, 2018, 04:31 PM |
| Vounatsos Michel | Chief Executive Officer | May 02, 2018 | Option Exercise | $274.13 | 750 | 205,598 | 9,368 | May 04, 2018, 06:09 PM |
| DENNER ALEXANDER J | Director | Apr 25, 2018 | Buy | $269.91 | 48,000 | 12,955,680 | 461,858 | Apr 27, 2018, 07:48 AM |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Mar 01, 2018 | Option Exercise | $282.35 | 642 | 181,269 | 4,302 | Mar 05, 2018, 04:41 PM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 27, 2018 | Sale | $290.83 | 259 | 75,325 | 6,553 | Feb 28, 2018, 05:39 PM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 23, 2018 | Option Exercise | $292.78 | 208 | 60,898 | 6,812 | Feb 27, 2018, 06:25 PM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 23, 2018 | Sale | $293.44 | 908 | 266,444 | 6,553 | Feb 27, 2018, 06:25 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 23, 2018 | Option Exercise | $292.78 | 28 | 8,198 | 4,744 | Feb 27, 2018, 06:24 PM |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Feb 23, 2018 | Option Exercise | $292.78 | 381 | 111,549 | 24,844 | Feb 27, 2018, 06:22 PM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 22, 2018 | Option Exercise | $284.81 | 727 | 207,057 | 7,461 | Feb 26, 2018, 04:12 PM |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Feb 22, 2018 | Option Exercise | $284.81 | 727 | 207,057 | 24,368 | Feb 26, 2018, 12:00 AM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 22, 2018 | Option Exercise | $284.81 | 58 | 16,519 | 4,680 | Feb 26, 2018, 12:00 AM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 20, 2018 | Sale | $292.00 | 743 | 216,956 | 6,553 | Feb 21, 2018, 04:10 PM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 15, 2018 | Sale | $298.85 | 1,294 | 386,712 | 7,296 | Feb 20, 2018, 08:09 PM |
| Vounatsos Michel | Chief Executive Officer | Feb 15, 2018 | Option Exercise | $299.38 | 1,877 | 561,936 | 8,356 | Feb 20, 2018, 04:27 PM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 15, 2018 | Option Exercise | $299.38 | 596 | 178,430 | 8,590 | Feb 20, 2018, 04:25 PM |
| Ehlers Michael D | EVP, Research and Development | Feb 15, 2018 | Option Exercise | $299.38 | 509 | 152,384 | 4,898 | Feb 20, 2018, 04:20 PM |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Feb 15, 2018 | Option Exercise | $299.38 | 510 | 152,684 | 23,460 | Feb 20, 2018, 04:17 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 15, 2018 | Option Exercise | $299.38 | 56 | 16,765 | 4,544 | Feb 20, 2018, 12:00 AM |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Feb 15, 2018 | Option Exercise | $299.38 | 442 | 132,326 | 4,412 | Feb 20, 2018, 12:00 AM |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 12, 2018 | Option Exercise | $316.63 | 1,316 | 416,685 | 7,847 | Feb 14, 2018, 06:37 PM |
| PANGIA ROBERT W | Director | Jan 09, 2018 | Option Exercise | $57.83 | 5,832 | 337,265 | 23,539 | Jan 10, 2018, 05:28 PM |
| PANGIA ROBERT W | Director | Jan 09, 2018 | Sale | $329.65 | 5,832 | 1,922,519 | 17,707 | Jan 10, 2018, 05:28 PM |
| Vounatsos Michel | Chief Executive Officer | Dec 29, 2017 | Buy | $320.55 | 780 | 250,029 | 4,879 | Jan 02, 2018, 04:21 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Dec 01, 2017 | Option Exercise | $319.35 | 157 | 50,138 | 4,542 | Dec 05, 2017, 04:36 PM |
| DENNER ALEXANDER J | Director | Nov 28, 2017 | Buy | $316.12 | 20,000 | 6,322,400 | 403,858 | Nov 30, 2017, 07:30 AM |
| DENNER ALEXANDER J | Director | Nov 29, 2017 | Buy | $319.84 | 10,000 | 3,198,400 | 413,858 | Nov 30, 2017, 07:30 AM |
| DENNER ALEXANDER J | Director | Aug 31, 2017 | Option Exercise | $316.56 | 933 | 295,350 | 383,858 | Aug 31, 2017, 09:45 PM |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Jul 25, 2017 | Sale | $290.01 | 4,974 | 1,442,510 | 22,258 | Jul 26, 2017, 04:22 PM |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Jul 19, 2017 | Sale | $285.00 | 7,758 | 2,211,030 | 27,232 | Jul 20, 2017, 05:00 PM |
| Posner Brian S | Director | Jun 09, 2017 | Sale | $256.31 | 1,084 | 277,840 | 6,330 | Jun 12, 2017, 04:29 PM |
| Ehlers Michael D | EVP, Research and Development | Jun 01, 2017 | Option Exercise | $252.38 | 747 | 188,528 | 3,616 | Jun 05, 2017, 04:38 PM |
| Vounatsos Michel | Chief Executive Officer | May 02, 2017 | Option Exercise | $271.34 | 564 | 153,036 | 4,099 | May 04, 2017, 04:16 PM |
| Vounatsos Michel | Chief Executive Officer | May 01, 2017 | Buy | $271.35 | 1,402 | 380,433 | 2,927 | May 02, 2017, 04:18 PM |
| DENNER ALEXANDER J | Director | Apr 27, 2017 | Buy | $278.50 | 73,858 | 20,569,476 | 383,858 | May 01, 2017, 05:47 PM |
| Clancy Paul J | Executive VP and CFO | Apr 25, 2017 | Sale | $290.00 | 9,892 | 2,868,680 | 10,813 | Apr 27, 2017, 04:23 PM |
| Clancy Paul J | Executive VP and CFO | Mar 13, 2017 | Sale | $291.55 | 9,891 | 2,883,721 | 20,705 | Mar 14, 2017, 07:32 PM |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Mar 01, 2017 | Option Exercise | $293.26 | 157 | 46,042 | 561 | Mar 03, 2017, 06:07 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Mar 01, 2017 | Sale | $290.07 | 973 | 282,238 | 9,041 | Mar 03, 2017, 06:02 PM |
| Clancy Paul J | Executive VP and CFO | Feb 28, 2017 | Option Exercise | $279.35 | 3,054 | 853,135 | 30,596 | Mar 02, 2017, 05:24 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 28, 2017 | Option Exercise | $278.17 | 2,981 | 829,217 | 10,014 | Mar 02, 2017, 05:22 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 28, 2017 | Option Exercise | $278.54 | 2,409 | 670,996 | 34,990 | Mar 02, 2017, 05:20 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 28, 2017 | Option Exercise | $285.23 | 89 | 25,386 | 4,505 | Mar 02, 2017, 05:18 PM |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Feb 28, 2017 | Option Exercise | $286.64 | 738 | 211,542 | 8,752 | Mar 02, 2017, 05:16 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 28, 2017 | Option Exercise | $278.66 | 2,456 | 684,399 | 7,177 | Mar 02, 2017, 05:12 PM |
| PANGIA ROBERT W | Director | Jan 09, 2017 | Option Exercise | $52.22 | 5,450 | 284,599 | 22,078 | Jan 10, 2017, 04:15 PM |
| PANGIA ROBERT W | Director | Jan 09, 2017 | Sale | $295.39 | 5,450 | 1,609,876 | 16,628 | Jan 10, 2017, 04:15 PM |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Dec 01, 2016 | Option Exercise | $295.78 | 171 | 50,578 | 7,408 | Dec 05, 2016, 04:34 PM |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Dec 01, 2016 | Sale | $296.53 | 48 | 14,233 | 7,360 | Dec 05, 2016, 04:34 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Dec 01, 2016 | Option Exercise | $295.78 | 53 | 15,676 | 3,884 | Dec 05, 2016, 04:32 PM |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Oct 04, 2016 | Sale | $311.94 | 262 | 81,728 | 7,579 | Oct 05, 2016, 04:24 PM |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Oct 01, 2016 | Option Exercise | $313.03 | 1,888 | 591,001 | 8,221 | Oct 04, 2016, 05:02 PM |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Oct 03, 2016 | Sale | $313.00 | 380 | 118,940 | 7,841 | Oct 04, 2016, 05:02 PM |
| DORSA CAROLINE | Director | Sep 22, 2016 | Option Exercise | $53.64 | 27,570 | 1,478,855 | 44,663 | Sep 26, 2016, 04:24 PM |
| DORSA CAROLINE | Director | Sep 22, 2016 | Sale | $314.00 | 27,570 | 8,656,980 | 17,093 | Sep 26, 2016, 04:24 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 21, 2016 | Sale | $280.00 | 157 | 43,960 | 54,779 | Jul 22, 2016, 05:03 PM |
| Koppel Adam | EVP, Strategy and Bus. Dev. | Jun 06, 2016 | Sale | $290.00 | 555 | 160,950 | 2,402 | Jun 07, 2016, 04:09 PM |
| Koppel Adam | EVP, Strategy and Bus. Dev. | Jun 02, 2016 | Option Exercise | $289.73 | 534 | 154,716 | 2,957 | Jun 06, 2016, 08:48 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 03, 2016 | Sale | $290.00 | 842 | 244,180 | 54,936 | Jun 06, 2016, 08:14 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 01, 2016 | Sale | $287.97 | 487 | 140,241 | 55,778 | Jun 02, 2016, 04:39 PM |
| SCANGOS GEORGE A | Chief Executive Officer | May 31, 2016 | Sale | $290.00 | 3,368 | 976,720 | 56,265 | Jun 02, 2016, 04:39 PM |
| SCANGOS GEORGE A | Chief Executive Officer | May 25, 2016 | Sale | $280.00 | 157 | 43,960 | 59,633 | May 27, 2016, 08:59 AM |
| SCANGOS GEORGE A | Chief Executive Officer | May 02, 2016 | Sale | $274.74 | 487 | 133,798 | 59,790 | May 04, 2016, 05:03 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2016 | Option Exercise | $274.99 | 113 | 31,074 | 3,007 | May 02, 2016, 04:36 PM |
| Koppel Adam | EVP, Strategy and Bus. Dev. | Apr 06, 2016 | Sale | $275.00 | 102 | 28,050 | 1,848 | Apr 07, 2016, 05:03 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 06, 2016 | Sale | $280.00 | 157 | 43,960 | 60,277 | Apr 07, 2016, 05:01 PM |
| Artavanis-Tsakonas Spyridon | EVP, Chief Scientific Officer | Apr 02, 2016 | Option Exercise | $260.54 | 459 | 119,588 | 3,150 | Apr 05, 2016, 05:06 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 01, 2016 | Sale | $258.83 | 487 | 126,050 | 60,434 | Apr 05, 2016, 05:02 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 01, 2016 | Sale | $261.37 | 487 | 127,287 | 60,921 | Mar 03, 2016, 04:36 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 25, 2016 | Sale | $261.90 | 183 | 47,928 | 7,990 | Feb 26, 2016, 04:08 PM |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Feb 25, 2016 | Sale | $261.90 | 84 | 22,000 | 8,127 | Feb 26, 2016, 04:06 PM |
| Clancy Paul J | Executive VP and CFO | Feb 23, 2016 | Option Exercise | $258.99 | 273 | 70,704 | 26,870 | Feb 25, 2016, 05:13 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 23, 2016 | Option Exercise | $258.99 | 22 | 5,698 | 2,687 | Feb 25, 2016, 05:09 PM |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Feb 23, 2016 | Option Exercise | $258.99 | 48 | 12,432 | 2,549 | Feb 25, 2016, 05:07 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 23, 2016 | Option Exercise | $258.99 | 300 | 77,697 | 31,840 | Feb 25, 2016, 05:05 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 23, 2016 | Option Exercise | $258.99 | 382 | 98,934 | 30,516 | Feb 25, 2016, 05:04 PM |
| Koppel Adam | EVP, Strategy and Bus. Dev. | Feb 23, 2016 | Option Exercise | $258.99 | 98 | 25,381 | 1,865 | Feb 25, 2016, 05:02 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 23, 2016 | Option Exercise | $258.99 | 300 | 77,697 | 3,937 | Feb 25, 2016, 05:01 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 23, 2016 | Option Exercise | $258.99 | 273 | 70,704 | 8,326 | Feb 25, 2016, 04:59 PM |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Feb 23, 2016 | Option Exercise | $258.99 | 162 | 41,956 | 8,211 | Feb 25, 2016, 04:57 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 23, 2016 | Option Exercise | $258.99 | 164 | 42,474 | 8,173 | Feb 25, 2016, 04:52 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 23, 2016 | Option Exercise | $258.99 | 1,395 | 361,291 | 61,417 | Feb 25, 2016, 04:51 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 17, 2016 | Sale | $256.16 | 487 | 124,750 | 59,848 | Feb 19, 2016, 04:20 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 17, 2016 | Sale | $256.16 | 722 | 184,948 | 7,990 | Feb 19, 2016, 04:18 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 12, 2016 | Option Exercise | $247.22 | 11,815 | 2,920,904 | 60,335 | Feb 17, 2016, 06:03 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 12, 2016 | Option Exercise | $247.22 | 1,552 | 383,685 | 30,088 | Feb 17, 2016, 06:01 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 12, 2016 | Option Exercise | $247.22 | 1,369 | 338,444 | 3,601 | Feb 17, 2016, 06:00 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 12, 2016 | Option Exercise | $247.22 | 26 | 6,428 | 2,643 | Feb 17, 2016, 05:59 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 12, 2016 | Option Exercise | $247.22 | 1,827 | 451,671 | 8,712 | Feb 17, 2016, 05:57 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 12, 2016 | Option Exercise | $247.22 | 1,314 | 324,847 | 8,020 | Feb 17, 2016, 05:56 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 12, 2016 | Option Exercise | $247.22 | 1,328 | 328,308 | 31,504 | Feb 17, 2016, 05:55 PM |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Feb 12, 2016 | Option Exercise | $247.22 | 352 | 87,021 | 2,452 | Feb 17, 2016, 05:54 PM |
| Clancy Paul J | Executive VP and CFO | Feb 12, 2016 | Option Exercise | $247.22 | 1,699 | 420,027 | 26,564 | Feb 17, 2016, 05:53 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 09, 2016 | Option Exercise | $249.99 | 5,305 | 1,326,197 | 47,059 | Feb 10, 2016, 04:19 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 08, 2016 | Option Exercise | $250.77 | 426 | 106,828 | 8,592 | Feb 10, 2016, 04:17 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 09, 2016 | Sale | $246.54 | 852 | 210,052 | 7,740 | Feb 10, 2016, 04:17 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 08, 2016 | Option Exercise | $250.77 | 822 | 206,133 | 29,543 | Feb 09, 2016, 04:58 PM |
| Clancy Paul J | Executive VP and CFO | Feb 08, 2016 | Option Exercise | $250.77 | 1,047 | 262,556 | 24,404 | Feb 09, 2016, 04:53 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 08, 2016 | Option Exercise | $250.77 | 1,324 | 332,019 | 28,342 | Feb 09, 2016, 04:51 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 08, 2016 | Option Exercise | $250.77 | 890 | 223,185 | 6,140 | Feb 09, 2016, 04:48 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 01, 2016 | Option Exercise | $273.45 | 812 | 222,041 | 1,654 | Feb 02, 2016, 04:05 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 01, 2016 | Option Exercise | $273.45 | 2,466 | 674,328 | 2,466 | Feb 02, 2016, 04:05 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Dec 03, 2015 | Option Exercise | $275.44 | 393 | 108,248 | 8,181 | Dec 07, 2015, 04:20 PM |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Dec 04, 2015 | Sale | $277.00 | 441 | 122,157 | 7,740 | Dec 07, 2015, 04:20 PM |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Dec 01, 2015 | Option Exercise | $290.04 | 171 | 49,597 | 7,923 | Dec 03, 2015, 04:19 PM |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Dec 02, 2015 | Sale | $289.14 | 48 | 13,879 | 7,875 | Dec 03, 2015, 04:19 PM |
| DENNER ALEXANDER J | Director | Oct 23, 2015 | Buy | $276.77 | 100,000 | 27,676,999 | 310,000 | Oct 26, 2015, 07:03 PM |
| DENNER ALEXANDER J | Director | Oct 22, 2015 | Buy | $277.80 | 210,000 | 58,337,997 | 210,000 | Oct 26, 2015, 07:03 PM |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Oct 05, 2015 | Sale | $291.43 | 269 | 78,395 | 8,094 | Oct 06, 2015, 04:40 PM |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Oct 01, 2015 | Option Exercise | $287.30 | 1,666 | 478,642 | 9,642 | Oct 05, 2015, 04:10 PM |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Oct 02, 2015 | Sale | $283.38 | 417 | 118,169 | 8,363 | Oct 05, 2015, 04:10 PM |
| PAPADOPOULOS STELIOS | Director | Jul 27, 2015 | Buy | $304.78 | 5,000 | 1,523,880 | 5,000 | Jul 27, 2015, 05:03 PM |
| PAPADOPOULOS STELIOS | Director | Jul 27, 2015 | Buy | $304.98 | 5,000 | 1,524,895 | 5,000 | Jul 27, 2015, 05:03 PM |
| Posner Brian S | Director | Jun 22, 2015 | Sale | $415.00 | 470 | 195,050 | 5,275 | Jun 23, 2015, 04:14 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Jun 19, 2015 | Sale | $410.00 | 3,841 | 1,574,810 | 11,817 | Jun 22, 2015, 04:15 PM |
| Posner Brian S | Director | Jun 15, 2015 | Sale | $386.64 | 400 | 154,656 | 5,745 | Jun 16, 2015, 06:54 PM |
| Koppel Adam | SVP, Chief Strategy Officer | Jun 02, 2015 | Option Exercise | $387.62 | 852 | 330,252 | 1,662 | Jun 04, 2015, 05:49 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 01, 2015 | Sale | $398.87 | 1,362 | 543,261 | 41,090 | Jun 02, 2015, 04:10 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2015 | Option Exercise | $386.22 | 113 | 43,643 | 1,761 | May 05, 2015, 04:36 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2015 | Option Exercise | $386.22 | 347 | 134,018 | 1,874 | May 05, 2015, 04:36 PM |
| SCANGOS GEORGE A | Chief Executive Officer | May 01, 2015 | Sale | $377.52 | 1,362 | 514,182 | 42,452 | May 05, 2015, 04:34 PM |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Apr 02, 2015 | Option Exercise | $412.44 | 460 | 189,722 | 1,674 | Apr 03, 2015, 04:24 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 01, 2015 | Sale | $423.20 | 1,362 | 576,398 | 43,814 | Apr 02, 2015, 04:29 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 27, 2015 | Sale | $430.12 | 430 | 184,952 | 8,574 | Mar 30, 2015, 04:13 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Mar 25, 2015 | Option Exercise | $65.85 | 5,066 | 333,571 | 37,577 | Mar 26, 2015, 04:31 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Mar 25, 2015 | Sale | $449.06 | 12,010 | 5,393,211 | 25,567 | Mar 26, 2015, 04:31 PM |
| Rowinsky Eric K | Director | Mar 20, 2015 | Option Exercise | $59.82 | 11,667 | 697,920 | 22,977 | Mar 23, 2015, 04:33 PM |
| Rowinsky Eric K | Director | Mar 20, 2015 | Sale | $475.00 | 11,667 | 5,541,825 | 11,310 | Mar 23, 2015, 04:33 PM |
| Rowinsky Eric K | Director | Mar 19, 2015 | Option Exercise | $59.82 | 2,333 | 139,560 | 13,643 | Mar 20, 2015, 05:03 PM |
| Rowinsky Eric K | Director | Mar 19, 2015 | Sale | $436.14 | 2,333 | 1,017,508 | 11,310 | Mar 20, 2015, 05:03 PM |
| Rowinsky Eric K | Director | Mar 17, 2015 | Option Exercise | $59.82 | 4,667 | 279,180 | 15,977 | Mar 18, 2015, 05:03 PM |
| Rowinsky Eric K | Director | Mar 17, 2015 | Sale | $425.45 | 4,667 | 1,985,589 | 11,310 | Mar 18, 2015, 05:03 PM |
| DiPietro Kenneth | EVP Human Resources | Mar 16, 2015 | Sale | $415.46 | 803 | 333,614 | 0 | Mar 17, 2015, 08:10 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 13, 2015 | Sale | $412.69 | 537 | 221,613 | 45,176 | Mar 16, 2015, 08:39 PM |
| SHERWIN STEPHEN A | Director | Mar 10, 2015 | Option Exercise | $59.82 | 6,000 | 358,920 | 10,150 | Mar 11, 2015, 04:17 PM |
| SHERWIN STEPHEN A | Director | Mar 10, 2015 | Sale | $409.67 | 6,000 | 2,458,020 | 4,150 | Mar 11, 2015, 04:17 PM |
| Rowinsky Eric K | Director | Mar 09, 2015 | Option Exercise | $59.82 | 4,666 | 279,120 | 15,976 | Mar 11, 2015, 04:15 PM |
| Rowinsky Eric K | Director | Mar 09, 2015 | Sale | $417.23 | 4,666 | 1,946,795 | 11,310 | Mar 11, 2015, 04:15 PM |
| PANGIA ROBERT W | Director | Mar 10, 2015 | Option Exercise | $47.71 | 3,625 | 172,954 | 17,998 | Mar 11, 2015, 04:13 PM |
| PANGIA ROBERT W | Director | Mar 10, 2015 | Sale | $413.40 | 3,625 | 1,498,578 | 17,798 | Mar 11, 2015, 04:13 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 01, 2015 | Option Exercise | $409.59 | 2,826 | 1,157,501 | 12,178 | Mar 03, 2015, 04:44 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 02, 2015 | Sale | $409.49 | 3,174 | 1,299,715 | 12,078 | Mar 03, 2015, 04:44 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 02, 2015 | Sale | $410.67 | 825 | 338,803 | 45,713 | Mar 03, 2015, 04:39 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 12, 2015 | Option Exercise | $392.11 | 8 | 3,137 | 1,302 | Feb 23, 2015, 04:24 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 19, 2015 | Sale | $401.04 | 537 | 215,358 | 46,538 | Feb 20, 2015, 04:28 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 17, 2015 | Sale | $389.11 | 825 | 321,016 | 47,075 | Feb 18, 2015, 04:45 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 17, 2015 | Sale | $389.11 | 2,128 | 828,026 | 4,321 | Feb 18, 2015, 04:41 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 17, 2015 | Sale | $389.11 | 1,188 | 462,263 | 803 | Feb 18, 2015, 04:37 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 17, 2015 | Sale | $389.11 | 418 | 162,648 | 15,004 | Feb 18, 2015, 04:36 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 12, 2015 | Option Exercise | $392.11 | 12,125 | 4,754,334 | 47,900 | Feb 17, 2015, 09:32 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 12, 2015 | Option Exercise | $392.11 | 20 | 7,842 | 1,446 | Feb 17, 2015, 09:16 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 12, 2015 | Option Exercise | $392.11 | 1,712 | 671,292 | 6,449 | Feb 17, 2015, 08:54 PM |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Feb 12, 2015 | Option Exercise | $392.11 | 394 | 154,491 | 1,159 | Feb 17, 2015, 08:50 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 12, 2015 | Option Exercise | $392.11 | 757 | 296,827 | 15,422 | Feb 17, 2015, 08:47 PM |
| Clancy Paul J | Executive VP and CFO | Feb 12, 2015 | Option Exercise | $392.11 | 2,026 | 794,415 | 22,257 | Feb 17, 2015, 08:44 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 12, 2015 | Option Exercise | $392.11 | 1,761 | 690,506 | 32,511 | Feb 17, 2015, 08:40 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 12, 2015 | Option Exercise | $392.11 | 2,450 | 960,669 | 15,658 | Feb 17, 2015, 08:37 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 12, 2015 | Option Exercise | $392.11 | 1,776 | 696,387 | 27,867 | Feb 17, 2015, 08:34 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 12, 2015 | Option Exercise | $392.11 | 1,773 | 695,211 | 1,991 | Feb 17, 2015, 08:30 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 12, 2015 | Option Exercise | $392.11 | 1,697 | 665,411 | 8,132 | Feb 17, 2015, 08:26 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 10, 2015 | Sale | $398.11 | 1,143 | 455,039 | 15,417 | Feb 11, 2015, 04:26 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 09, 2015 | Option Exercise | $396.88 | 4,940 | 1,960,587 | 24,315 | Feb 11, 2015, 04:25 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 10, 2015 | Option Exercise | $395.13 | 8,871 | 3,505,198 | 34,277 | Feb 11, 2015, 04:25 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 08, 2015 | Option Exercise | $402.00 | 1,634 | 656,868 | 12,908 | Feb 10, 2015, 05:14 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 08, 2015 | Option Exercise | $402.00 | 818 | 328,836 | 23,807 | Feb 10, 2015, 05:12 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 09, 2015 | Option Exercise | $396.88 | 1,842 | 731,053 | 25,874 | Feb 10, 2015, 05:12 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 09, 2015 | Option Exercise | $396.88 | 681 | 270,275 | 15,717 | Feb 10, 2015, 05:11 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 08, 2015 | Option Exercise | $402.00 | 421 | 169,242 | 15,430 | Feb 10, 2015, 05:11 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 09, 2015 | Sale | $398.05 | 856 | 340,731 | 14,574 | Feb 10, 2015, 05:11 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 08, 2015 | Option Exercise | $402.00 | 1,275 | 512,550 | 4,527 | Feb 10, 2015, 05:10 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 09, 2015 | Option Exercise | $396.88 | 860 | 341,317 | 6,228 | Feb 10, 2015, 05:08 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 08, 2015 | Option Exercise | $402.00 | 883 | 354,966 | 5,264 | Feb 10, 2015, 05:08 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 09, 2015 | Option Exercise | $396.88 | 2,210 | 877,105 | 30,534 | Feb 10, 2015, 05:07 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 08, 2015 | Option Exercise | $402.00 | 1,537 | 617,874 | 28,053 | Feb 10, 2015, 05:07 PM |
| Clancy Paul J | Executive VP and CFO | Feb 08, 2015 | Option Exercise | $402.00 | 1,143 | 459,486 | 17,503 | Feb 10, 2015, 05:06 PM |
| Clancy Paul J | Executive VP and CFO | Feb 09, 2015 | Option Exercise | $396.88 | 2,210 | 877,105 | 19,984 | Feb 10, 2015, 05:06 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 02, 2015 | Sale | $389.03 | 1,656 | 644,234 | 0 | Feb 03, 2015, 06:35 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 01, 2015 | Option Exercise | $389.16 | 807 | 314,052 | 1,656 | Feb 02, 2015, 07:46 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 01, 2015 | Option Exercise | $389.16 | 2,059 | 801,280 | 11,074 | Feb 02, 2015, 07:43 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 01, 2015 | Option Exercise | $389.16 | 2,060 | 801,670 | 3,097 | Feb 02, 2015, 07:40 PM |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Dec 15, 2014 | Sale | $346.50 | 1,981 | 686,417 | 352 | Dec 16, 2014, 04:36 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Dec 03, 2014 | Option Exercise | $347.34 | 393 | 136,505 | 15,014 | Dec 05, 2014, 05:20 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Dec 04, 2014 | Sale | $345.88 | 440 | 152,187 | 14,574 | Dec 05, 2014, 05:20 PM |
| Holtzman Steven H | EVP Corporate Development | Dec 02, 2014 | Sale | $335.65 | 1,749 | 587,052 | 0 | Dec 03, 2014, 04:32 PM |
| Holtzman Steven H | EVP Corporate Development | Nov 11, 2014 | Sale | $330.00 | 1,750 | 577,500 | 1,749 | Nov 12, 2014, 04:24 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Nov 03, 2014 | Sale | $320.78 | 1,128 | 361,840 | 17,985 | Nov 04, 2014, 04:18 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Oct 01, 2014 | Sale | $330.97 | 1,127 | 373,003 | 19,113 | Oct 02, 2014, 04:44 PM |
| Holtzman Steven H | EVP Corporate Development | Oct 01, 2014 | Sale | $330.97 | 1,750 | 579,198 | 3,499 | Oct 02, 2014, 04:42 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Sep 02, 2014 | Sale | $345.47 | 1,128 | 389,690 | 20,240 | Sep 04, 2014, 04:15 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Aug 01, 2014 | Sale | $332.93 | 1,128 | 375,545 | 21,368 | Aug 04, 2014, 04:43 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 16, 2014 | Sale | $312.37 | 12,316 | 3,847,149 | 22,496 | Jul 18, 2014, 05:59 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 15, 2014 | Option Exercise | $312.00 | 10,062 | 3,139,344 | 34,812 | Jul 17, 2014, 04:45 PM |
| Posner Brian S | Director | Jun 20, 2014 | Sale | $315.00 | 605 | 190,575 | 6,000 | Jun 23, 2014, 04:37 PM |
| Posner Brian S | Director | Jun 13, 2014 | Sale | $310.50 | 700 | 217,350 | 6,605 | Jun 16, 2014, 04:37 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 02, 2014 | Sale | $318.93 | 484 | 154,362 | 23,535 | Jun 03, 2014, 04:29 PM |
| Holtzman Steven H | EVP Corporate Development | May 19, 2014 | Sale | $289.15 | 1,221 | 353,052 | 5,749 | May 20, 2014, 04:16 PM |
| SCANGOS GEORGE A | Chief Executive Officer | May 01, 2014 | Sale | $285.56 | 2,123 | 606,241 | 25,656 | May 02, 2014, 04:22 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2014 | Option Exercise | $286.75 | 113 | 32,403 | 916 | May 02, 2014, 04:20 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2014 | Option Exercise | $286.75 | 347 | 99,502 | 1,029 | May 02, 2014, 04:20 PM |
| Holtzman Steven H | EVP Corporate Development | Apr 17, 2014 | Sale | $291.00 | 1,221 | 355,311 | 6,970 | Apr 21, 2014, 05:07 PM |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Apr 02, 2014 | Option Exercise | $309.70 | 433 | 134,100 | 2,244 | Apr 03, 2014, 04:27 PM |
| PANGIA ROBERT W | Director | Apr 01, 2014 | Option Exercise | $47.55 | 6,250 | 297,187 | 20,253 | Apr 02, 2014, 04:19 PM |
| PANGIA ROBERT W | Director | Apr 01, 2014 | Sale | $308.42 | 6,250 | 1,927,625 | 14,003 | Apr 02, 2014, 04:19 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 01, 2014 | Sale | $308.42 | 2,123 | 654,776 | 26,142 | Apr 02, 2014, 04:16 PM |
| Posner Brian S | Director | Mar 31, 2014 | Sale | $296.76 | 3,000 | 890,275 | 8,935 | Apr 01, 2014, 04:15 PM |
| DORSA CAROLINE | Director | Mar 20, 2014 | Option Exercise | $53.64 | 10,000 | 536,400 | 24,468 | Mar 21, 2014, 04:17 PM |
| DORSA CAROLINE | Director | Mar 20, 2014 | Sale | $348.88 | 10,000 | 3,488,812 | 22,268 | Mar 21, 2014, 04:17 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Mar 19, 2014 | Sale | $352.29 | 3,505 | 1,234,776 | 9,886 | Mar 21, 2014, 04:15 PM |
| Holtzman Steven H | EVP Corporate Development | Mar 17, 2014 | Sale | $334.83 | 1,221 | 408,827 | 8,191 | Mar 18, 2014, 05:08 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 10, 2014 | Sale | $333.77 | 26,124 | 8,719,378 | 53,689 | Mar 12, 2014, 07:20 PM |
| LEAMING NANCY | Director | Mar 10, 2014 | Sale | $327.65 | 2,000 | 655,300 | 7,660 | Mar 12, 2014, 07:16 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Mar 11, 2014 | Sale | $336.83 | 8,428 | 2,838,766 | 9,054 | Mar 12, 2014, 07:15 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 04, 2014 | Sale | $342.58 | 3,171 | 1,086,321 | 15,407 | Mar 05, 2014, 03:12 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 03, 2014 | Option Exercise | $340.68 | 2,829 | 963,784 | 18,578 | Mar 04, 2014, 03:22 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 03, 2014 | Sale | $335.79 | 2,942 | 987,894 | 56,368 | Mar 04, 2014, 03:19 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 26, 2014 | Sale | $342.17 | 1,048 | 358,594 | 21,407 | Feb 27, 2014, 04:19 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 23, 2014 | Option Exercise | $347.11 | 940 | 326,283 | 22,455 | Feb 25, 2014, 02:21 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 23, 2014 | Option Exercise | $347.11 | 1,228 | 426,251 | 25,478 | Feb 25, 2014, 02:17 PM |
| Clancy Paul J | Executive VP and CFO | Feb 23, 2014 | Option Exercise | $347.11 | 2,018 | 700,468 | 15,455 | Feb 25, 2014, 02:11 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 23, 2014 | Option Exercise | $347.11 | 1,803 | 625,839 | 22,127 | Feb 25, 2014, 02:07 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 18, 2014 | Sale | $327.90 | 1,222 | 400,694 | 9,412 | Feb 19, 2014, 04:23 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 12, 2014 | Option Exercise | $323.04 | 1,685 | 544,322 | 11,481 | Feb 14, 2014, 04:48 PM |
| Clancy Paul J | Executive VP and CFO | Feb 12, 2014 | Option Exercise | $323.04 | 1,324 | 427,705 | 13,193 | Feb 14, 2014, 04:46 PM |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Feb 12, 2014 | Option Exercise | $323.04 | 239 | 77,207 | 1,702 | Feb 14, 2014, 04:45 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 12, 2014 | Option Exercise | $323.04 | 1,010 | 326,270 | 20,109 | Feb 14, 2014, 04:43 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 12, 2014 | Option Exercise | $323.04 | 367 | 118,556 | 14,092 | Feb 14, 2014, 04:42 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 13, 2014 | Sale | $316.42 | 425 | 134,478 | 21,407 | Feb 14, 2014, 04:42 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 12, 2014 | Option Exercise | $323.04 | 1,010 | 326,270 | 10,634 | Feb 14, 2014, 04:39 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 12, 2014 | Option Exercise | $323.04 | 8 | 2,584 | 682 | Feb 14, 2014, 04:38 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 12, 2014 | Option Exercise | $323.04 | 4,333 | 1,399,732 | 57,817 | Feb 14, 2014, 04:37 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 13, 2014 | Sale | $316.81 | 486 | 153,970 | 57,331 | Feb 14, 2014, 04:37 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 12, 2014 | Option Exercise | $323.04 | 956 | 308,826 | 1,290 | Feb 14, 2014, 04:36 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 13, 2014 | Sale | $316.81 | 1,290 | 408,685 | 0 | Feb 14, 2014, 04:36 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 12, 2014 | Option Exercise | $323.04 | 1,059 | 342,099 | 24,108 | Feb 14, 2014, 04:34 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 11, 2014 | Sale | $314.31 | 2,085 | 655,336 | 14,522 | Feb 12, 2014, 05:03 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 11, 2014 | Sale | $314.31 | 2,456 | 771,945 | 54,454 | Feb 12, 2014, 05:00 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 10, 2014 | Option Exercise | $315.54 | 8,880 | 2,801,995 | 55,417 | Feb 11, 2014, 07:55 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 09, 2014 | Option Exercise | $315.54 | 4,850 | 1,530,369 | 45,464 | Feb 11, 2014, 07:55 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 09, 2014 | Option Exercise | $315.54 | 861 | 271,680 | 10,752 | Feb 11, 2014, 07:52 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 08, 2014 | Option Exercise | $315.54 | 1,243 | 392,216 | 9,789 | Feb 11, 2014, 07:52 PM |
| Clancy Paul J | Executive VP and CFO | Feb 09, 2014 | Option Exercise | $315.54 | 2,212 | 697,974 | 11,710 | Feb 11, 2014, 07:49 PM |
| Clancy Paul J | Executive VP and CFO | Feb 08, 2014 | Option Exercise | $315.54 | 1,047 | 330,370 | 9,231 | Feb 11, 2014, 07:49 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 08, 2014 | Option Exercise | $315.54 | 1,636 | 516,223 | 9,593 | Feb 11, 2014, 07:47 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 08, 2014 | Option Exercise | $315.54 | 1,276 | 402,629 | 9,502 | Feb 11, 2014, 07:45 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 09, 2014 | Option Exercise | $315.54 | 594 | 187,431 | 15,752 | Feb 11, 2014, 07:43 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 08, 2014 | Option Exercise | $315.54 | 422 | 133,158 | 14,522 | Feb 11, 2014, 07:43 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 08, 2014 | Option Exercise | $315.54 | 819 | 258,427 | 16,814 | Feb 11, 2014, 06:07 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 09, 2014 | Option Exercise | $315.54 | 1,746 | 550,933 | 18,977 | Feb 11, 2014, 06:07 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 09, 2014 | Option Exercise | $315.54 | 2,212 | 697,974 | 22,921 | Feb 11, 2014, 06:07 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 08, 2014 | Option Exercise | $315.54 | 1,441 | 454,693 | 20,442 | Feb 11, 2014, 06:07 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 04, 2014 | Sale | $299.01 | 1,655 | 494,862 | 0 | Feb 05, 2014, 04:36 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 01, 2014 | Option Exercise | $312.64 | 808 | 252,613 | 1,655 | Feb 03, 2014, 05:29 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 01, 2014 | Option Exercise | $312.64 | 1,969 | 615,588 | 7,761 | Feb 03, 2014, 05:25 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 01, 2014 | Option Exercise | $312.64 | 1,701 | 531,801 | 8,396 | Feb 03, 2014, 05:20 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 01, 2014 | Option Exercise | $312.64 | 1,971 | 616,213 | 8,073 | Feb 03, 2014, 05:15 PM |
| Rowinsky Eric K | Director | Jan 21, 2014 | Sale | $310.09 | 2,020 | 626,382 | 10,440 | Jan 22, 2014, 04:49 PM |
| SCHENK LYNN | Director | Jan 15, 2014 | Sale | $297.48 | 1,000 | 297,480 | 3,100 | Jan 16, 2014, 10:27 AM |
| YOUNG WILLIAM | Director | Jan 08, 2014 | Sale | $285.11 | 15,000 | 4,276,590 | 18,509 | Jan 09, 2014, 04:24 PM |
| PANGIA ROBERT W | Director | Jan 06, 2014 | Option Exercise | $47.55 | 6,250 | 297,187 | 20,253 | Jan 07, 2014, 12:22 PM |
| PANGIA ROBERT W | Director | Jan 06, 2014 | Sale | $278.03 | 6,250 | 1,737,687 | 14,003 | Jan 07, 2014, 12:22 PM |
| SHERWIN STEPHEN A | Director | Jan 02, 2014 | Option Exercise | $59.82 | 5,500 | 329,010 | 9,460 | Jan 06, 2014, 11:19 AM |
| SHERWIN STEPHEN A | Director | Jan 02, 2014 | Sale | $279.28 | 5,500 | 1,536,059 | 7,660 | Jan 06, 2014, 11:19 AM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Dec 03, 2013 | Option Exercise | $287.76 | 394 | 113,377 | 14,106 | Dec 05, 2013, 02:53 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Dec 04, 2013 | Sale | $285.90 | 439 | 125,510 | 13,667 | Dec 05, 2013, 02:53 PM |
| SCHENK LYNN | Director | Dec 02, 2013 | Sale | $291.71 | 1,000 | 291,710 | 4,100 | Dec 02, 2013, 03:28 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Nov 22, 2013 | Option Exercise | $49.95 | 4,000 | 199,800 | 12,710 | Nov 25, 2013, 02:11 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Nov 22, 2013 | Sale | $288.00 | 4,000 | 1,152,000 | 8,710 | Nov 25, 2013, 02:11 PM |
| SCHENK LYNN | Director | Nov 01, 2013 | Sale | $245.00 | 1,000 | 245,000 | 5,100 | Nov 05, 2013, 12:18 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Nov 01, 2013 | Sale | $245.57 | 2,239 | 549,831 | 40,156 | Nov 05, 2013, 12:13 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Oct 22, 2013 | Option Exercise | $60.56 | 15,030 | 910,217 | 29,530 | Oct 23, 2013, 05:03 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Oct 22, 2013 | Sale | $250.11 | 15,030 | 3,759,123 | 14,500 | Oct 23, 2013, 05:03 PM |
| SCHENK LYNN | Director | Oct 01, 2013 | Sale | $242.85 | 1,000 | 242,850 | 6,100 | Oct 02, 2013, 05:09 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Oct 01, 2013 | Sale | $242.85 | 2,239 | 543,741 | 42,395 | Oct 02, 2013, 04:35 PM |
| DiPietro Kenneth | EVP Human Resources | Sep 30, 2013 | Sale | $242.00 | 1,440 | 348,480 | 0 | Oct 02, 2013, 01:36 PM |
| Clancy Paul J | Executive VP and CFO | Sep 18, 2013 | Option Exercise | $49.65 | 26,785 | 1,329,875 | 33,872 | Sep 19, 2013, 02:14 PM |
| Clancy Paul J | Executive VP and CFO | Sep 18, 2013 | Sale | $245.00 | 26,785 | 6,562,325 | 7,087 | Sep 19, 2013, 02:14 PM |
| Clancy Paul J | Executive VP and CFO | Sep 16, 2013 | Option Exercise | $56.11 | 99,030 | 5,556,895 | 51,027 | Sep 18, 2013, 04:34 PM |
| Clancy Paul J | Executive VP and CFO | Sep 16, 2013 | Sale | $238.27 | 99,030 | 23,596,311 | 42,027 | Sep 18, 2013, 04:34 PM |
| Holtzman Steven H | EVP Corporate Development | Sep 17, 2013 | Sale | $238.98 | 3,501 | 836,669 | 4,885 | Sep 18, 2013, 04:31 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Sep 16, 2013 | Option Exercise | $49.65 | 9,820 | 487,563 | 24,320 | Sep 18, 2013, 04:28 PM |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Sep 16, 2013 | Sale | $240.10 | 9,820 | 2,357,821 | 14,500 | Sep 18, 2013, 04:28 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Sep 16, 2013 | Option Exercise | $49.59 | 4,000 | 198,360 | 12,710 | Sep 18, 2013, 04:26 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Sep 16, 2013 | Sale | $238.03 | 4,000 | 952,120 | 8,710 | Sep 18, 2013, 04:26 PM |
| SCHENK LYNN | Director | Sep 11, 2013 | Sale | $235.25 | 900 | 211,726 | 3,325 | Sep 13, 2013, 02:33 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Sep 03, 2013 | Sale | $214.40 | 2,239 | 480,042 | 45,534 | Sep 04, 2013, 04:52 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Aug 26, 2013 | Sale | $211.35 | 4,368 | 923,168 | 4,571 | Aug 28, 2013, 12:30 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Aug 01, 2013 | Sale | $218.82 | 2,239 | 489,938 | 45,761 | Aug 02, 2013, 10:55 AM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 16, 2013 | Sale | $223.94 | 2,239 | 501,402 | 48,000 | Jul 18, 2013, 11:24 AM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 15, 2013 | Option Exercise | $224.33 | 20,011 | 4,489,068 | 60,177 | Jul 16, 2013, 06:19 PM |
| DENNER ALEXANDER J | Director | Jun 14, 2013 | Sale | $212.00 | 2,900 | 614,800 | 6,325 | Jun 17, 2013, 03:46 PM |
| PAPADOPOULOS STELIOS | Director | Jun 11, 2013 | Sale | $219.62 | 2,020 | 443,632 | 12,930 | Jun 13, 2013, 04:27 PM |
| Posner Brian S | Director | Jun 11, 2013 | Sale | $219.62 | 2,020 | 443,632 | 8,130 | Jun 13, 2013, 04:23 PM |
| SCHENK LYNN | Director | Jun 10, 2013 | Sale | $225.82 | 2,000 | 451,633 | 3,920 | Jun 11, 2013, 03:55 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 03, 2013 | Sale | $234.16 | 1,598 | 374,188 | 48,911 | Jun 04, 2013, 03:29 PM |
| SHERWIN STEPHEN A | Director | Jun 03, 2013 | Option Exercise | $59.82 | 12,825 | 767,191 | 15,480 | Jun 04, 2013, 03:26 PM |
| SHERWIN STEPHEN A | Director | Jun 03, 2013 | Sale | $233.26 | 12,825 | 2,991,605 | 12,047 | Jun 04, 2013, 03:26 PM |
| Mulligan Richard | Director | May 29, 2013 | Option Exercise | $53.43 | 3,000 | 160,290 | 5,020 | May 31, 2013, 12:27 PM |
| DENNER ALEXANDER J | Director | May 29, 2013 | Option Exercise | $53.43 | 3,000 | 160,290 | 7,920 | May 31, 2013, 12:26 PM |
| Mulligan Richard | Director | May 28, 2013 | Option Exercise | $53.43 | 37,975 | 2,029,004 | 37,020 | May 29, 2013, 05:16 PM |
| Mulligan Richard | Director | May 28, 2013 | Sale | $240.69 | 37,975 | 9,140,100 | 36,120 | May 29, 2013, 05:16 PM |
| DENNER ALEXANDER J | Director | May 28, 2013 | Option Exercise | $53.43 | 37,975 | 2,029,004 | 39,920 | May 29, 2013, 05:15 PM |
| DENNER ALEXANDER J | Director | May 28, 2013 | Sale | $240.57 | 37,975 | 9,135,697 | 37,620 | May 29, 2013, 05:15 PM |
| PANGIA ROBERT W | Director | May 28, 2013 | Sale | $237.23 | 5,900 | 1,399,657 | 12,698 | May 29, 2013, 05:12 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | May 03, 2013 | Option Exercise | $218.85 | 866 | 189,524 | 8,710 | May 07, 2013, 01:36 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | May 03, 2013 | Option Exercise | $218.85 | 866 | 189,524 | 18,060 | May 07, 2013, 01:33 PM |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2013 | Option Exercise | $214.33 | 114 | 24,434 | 375 | May 03, 2013, 03:10 PM |
| SCANGOS GEORGE A | Chief Executive Officer | May 01, 2013 | Sale | $215.39 | 1,598 | 344,193 | 50,509 | May 03, 2013, 03:07 PM |
| Clancy Paul J | Executive VP and CFO | Apr 30, 2013 | Sale | $224.66 | 14,489 | 3,255,090 | 19,608 | May 01, 2013, 03:45 PM |
| Clancy Paul J | Executive VP and CFO | Apr 29, 2013 | Sale | $219.71 | 9,123 | 2,004,414 | 21,576 | May 01, 2013, 03:45 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 01, 2013 | Sale | $193.66 | 1,598 | 309,469 | 52,107 | Apr 03, 2013, 12:31 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 01, 2013 | Sale | $193.66 | 1,598 | 309,469 | 52,107 | Apr 02, 2013, 01:23 PM |
| Mulligan Richard | Director | Mar 22, 2013 | Sale | $176.88 | 2,900 | 512,952 | 2,020 | Mar 25, 2013, 02:20 PM |
| SHERWIN STEPHEN A | Director | Mar 22, 2013 | Sale | $176.88 | 1,500 | 265,320 | 2,655 | Mar 25, 2013, 02:18 PM |
| Posner Brian S | Director | Mar 18, 2013 | Sale | $174.81 | 4,500 | 786,645 | 10,150 | Mar 19, 2013, 03:15 PM |
| Mulligan Richard | Director | Mar 13, 2013 | Sale | $175.38 | 7,980 | 1,399,530 | 9,920 | Mar 13, 2013, 02:56 PM |
| PAPADOPOULOS STELIOS | Director | Mar 11, 2013 | Option Exercise | $58.44 | 46,675 | 2,727,463 | 49,950 | Mar 12, 2013, 02:22 PM |
| PAPADOPOULOS STELIOS | Director | Mar 11, 2013 | Sale | $172.26 | 46,675 | 8,040,003 | 18,916 | Mar 12, 2013, 02:22 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Mar 01, 2013 | Option Exercise | $168.70 | 630 | 106,281 | 9,410 | Mar 04, 2013, 04:42 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 01, 2013 | Sale | $165.30 | 1,598 | 264,149 | 53,705 | Mar 04, 2013, 04:40 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 23, 2013 | Option Exercise | $164.40 | 1,227 | 201,719 | 18,759 | Feb 26, 2013, 01:26 PM |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 23, 2013 | Option Exercise | $164.40 | 1,803 | 296,413 | 15,135 | Feb 26, 2013, 01:25 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Feb 23, 2013 | Option Exercise | $164.40 | 722 | 118,697 | 10,040 | Feb 26, 2013, 01:24 PM |
| Clancy Paul J | Executive VP and CFO | Feb 23, 2013 | Option Exercise | $164.40 | 2,021 | 332,252 | 30,699 | Feb 26, 2013, 01:23 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 13, 2013 | Sale | $163.39 | 1,598 | 261,097 | 55,303 | Feb 14, 2013, 02:59 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 09, 2013 | Option Exercise | $164.44 | 861 | 141,583 | 5,511 | Feb 12, 2013, 05:26 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 08, 2013 | Option Exercise | $164.44 | 831 | 136,650 | 4,548 | Feb 12, 2013, 05:26 PM |
| Clancy Paul J | Executive VP and CFO | Feb 09, 2013 | Option Exercise | $164.44 | 1,731 | 284,646 | 28,439 | Feb 12, 2013, 05:24 PM |
| Clancy Paul J | Executive VP and CFO | Feb 08, 2013 | Option Exercise | $164.44 | 899 | 147,832 | 25,478 | Feb 12, 2013, 05:24 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 08, 2013 | Option Exercise | $164.44 | 940 | 154,574 | 8,386 | Feb 12, 2013, 05:22 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Feb 08, 2013 | Option Exercise | $164.44 | 523 | 86,002 | 8,236 | Feb 12, 2013, 05:20 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Feb 09, 2013 | Option Exercise | $164.44 | 893 | 146,845 | 9,233 | Feb 12, 2013, 05:20 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 09, 2013 | Option Exercise | $164.44 | 1,275 | 209,661 | 13,117 | Feb 12, 2013, 05:12 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 08, 2013 | Option Exercise | $164.44 | 702 | 115,437 | 10,483 | Feb 12, 2013, 05:12 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 08, 2013 | Option Exercise | $164.44 | 1,133 | 186,311 | 14,532 | Feb 12, 2013, 05:10 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 09, 2013 | Option Exercise | $164.44 | 1,836 | 301,912 | 17,388 | Feb 12, 2013, 05:10 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 08, 2013 | Option Exercise | $164.44 | 1,252 | 205,879 | 8,939 | Feb 12, 2013, 05:08 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 10, 2013 | Option Exercise | $164.44 | 8,890 | 1,461,872 | 56,901 | Feb 12, 2013, 05:05 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 09, 2013 | Option Exercise | $164.44 | 3,723 | 612,210 | 46,958 | Feb 12, 2013, 05:05 PM |
| PANGIA ROBERT W | Director | Feb 06, 2013 | Option Exercise | $66.29 | 2,500 | 165,725 | 21,098 | Feb 07, 2013, 01:58 PM |
| PANGIA ROBERT W | Director | Feb 06, 2013 | Sale | $165.55 | 2,500 | 413,875 | 18,598 | Feb 07, 2013, 01:58 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Feb 06, 2013 | Option Exercise | $49.65 | 10,000 | 496,500 | 17,653 | Feb 07, 2013, 01:55 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Feb 06, 2013 | Sale | $165.55 | 10,000 | 1,655,500 | 7,653 | Feb 07, 2013, 01:55 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 01, 2013 | Option Exercise | $157.30 | 1,679 | 264,107 | 7,185 | Feb 05, 2013, 06:23 PM |
| Holtzman Steven H | EVP Corporate Development | Feb 01, 2013 | Option Exercise | $157.30 | 1,678 | 263,949 | 6,982 | Feb 05, 2013, 04:25 PM |
| DiPietro Kenneth | EVP Human Resources | Feb 01, 2013 | Option Exercise | $157.30 | 711 | 111,840 | 1,440 | Feb 05, 2013, 04:23 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 01, 2013 | Option Exercise | $157.30 | 1,491 | 234,534 | 3,095 | Feb 05, 2013, 04:22 PM |
| DENNER ALEXANDER J | Director | Dec 26, 2012 | Sale | $148.89 | 3,989 | 593,914 | 8,911 | Dec 28, 2012, 10:15 AM |
| DENNER ALEXANDER J | Director | Dec 27, 2012 | Sale | $148.36 | 3,991 | 592,086 | 6,220 | Dec 28, 2012, 10:15 AM |
| SCANGOS GEORGE A | Chief Executive Officer | Nov 01, 2012 | Sale | $139.42 | 2,472 | 344,640 | 52,898 | Nov 02, 2012, 03:49 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Oct 01, 2012 | Sale | $149.16 | 3,654 | 545,031 | 54,142 | Oct 02, 2012, 01:10 PM |
| PANGIA ROBERT W | Director | Sep 17, 2012 | Option Exercise | $66.29 | 5,000 | 331,450 | 23,598 | Sep 18, 2012, 05:26 PM |
| PANGIA ROBERT W | Director | Sep 17, 2012 | Sale | $155.00 | 5,000 | 775,000 | 18,598 | Sep 18, 2012, 05:26 PM |
| PANGIA ROBERT W | Director | Sep 06, 2012 | Option Exercise | $66.29 | 5,000 | 331,450 | 23,598 | Sep 10, 2012, 02:20 PM |
| PANGIA ROBERT W | Director | Sep 06, 2012 | Sale | $150.00 | 5,000 | 750,000 | 18,598 | Sep 10, 2012, 02:20 PM |
| SHERWIN STEPHEN A | Director | Sep 04, 2012 | Sale | $145.90 | 2,000 | 291,800 | 4,155 | Sep 05, 2012, 03:20 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Sep 04, 2012 | Sale | $145.90 | 3,654 | 533,119 | 57,796 | Sep 05, 2012, 03:17 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Aug 02, 2012 | Sale | $142.99 | 1,165 | 166,583 | 9,020 | Aug 03, 2012, 11:12 AM |
| SCANGOS GEORGE A | Chief Executive Officer | Aug 01, 2012 | Sale | $146.30 | 3,655 | 534,727 | 61,450 | Aug 02, 2012, 03:24 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Jul 27, 2012 | Option Exercise | $57.04 | 58,070 | 3,312,157 | 68,255 | Jul 30, 2012, 02:58 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Jul 27, 2012 | Sale | $150.00 | 58,070 | 8,710,500 | 10,185 | Jul 30, 2012, 02:58 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 17, 2012 | Sale | $146.04 | 2,472 | 361,011 | 66,333 | Jul 18, 2012, 03:35 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 16, 2012 | Option Exercise | $144.61 | 17,679 | 2,556,560 | 76,357 | Jul 17, 2012, 01:03 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 02, 2012 | Sale | $143.50 | 1,183 | 169,761 | 63,917 | Jul 03, 2012, 10:40 AM |
| Pawlicki Raymond | SVP, Chief Information Officer | Jun 19, 2012 | Option Exercise | $49.59 | 10,000 | 495,900 | 17,653 | Jun 21, 2012, 11:41 AM |
| Pawlicki Raymond | SVP, Chief Information Officer | Jun 19, 2012 | Sale | $143.00 | 10,000 | 1,430,000 | 7,653 | Jun 21, 2012, 11:41 AM |
| ALEXANDER SUSAN H | EVP, General Counsel | Jun 15, 2012 | Option Exercise | $47.87 | 49,800 | 2,383,838 | 59,985 | Jun 18, 2012, 01:53 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Jun 15, 2012 | Sale | $140.00 | 49,800 | 6,972,000 | 10,185 | Jun 18, 2012, 01:53 PM |
| PANGIA ROBERT W | Director | Jun 15, 2012 | Option Exercise | $36.94 | 5,000 | 184,700 | 23,598 | Jun 18, 2012, 01:50 PM |
| PANGIA ROBERT W | Director | Jun 15, 2012 | Sale | $140.00 | 5,000 | 700,000 | 18,598 | Jun 18, 2012, 01:50 PM |
| Posner Brian S | Director | Jun 07, 2012 | Option Exercise | $71.38 | 2,500 | 178,450 | 15,130 | Jun 11, 2012, 11:22 AM |
| Posner Brian S | Director | Jun 07, 2012 | Sale | $135.00 | 2,500 | 337,500 | 12,630 | Jun 11, 2012, 11:22 AM |
| PANGIA ROBERT W | Director | Jun 04, 2012 | Option Exercise | $36.94 | 5,000 | 184,700 | 21,578 | Jun 05, 2012, 03:45 PM |
| PANGIA ROBERT W | Director | Jun 04, 2012 | Sale | $130.00 | 5,000 | 650,000 | 16,578 | Jun 05, 2012, 03:45 PM |
| SHERWIN STEPHEN A | Director | Jun 04, 2012 | Sale | $126.45 | 2,500 | 316,125 | 4,135 | Jun 05, 2012, 03:43 PM |
| Posner Brian S | Director | Jun 04, 2012 | Option Exercise | $71.38 | 2,400 | 171,312 | 15,030 | Jun 05, 2012, 03:41 PM |
| Posner Brian S | Director | Jun 04, 2012 | Sale | $126.45 | 2,400 | 303,480 | 12,630 | Jun 05, 2012, 03:41 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | Jun 04, 2012 | Sale | $126.45 | 1,068 | 135,049 | 7,653 | Jun 05, 2012, 03:39 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 01, 2012 | Sale | $128.63 | 1,183 | 152,169 | 65,100 | Jun 04, 2012, 04:26 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | May 03, 2012 | Option Exercise | $134.26 | 765 | 102,709 | 12,178 | May 04, 2012, 02:03 PM |
| Pawlicki Raymond | SVP, Chief Information Officer | May 03, 2012 | Option Exercise | $134.26 | 765 | 102,709 | 8,721 | May 04, 2012, 02:02 PM |
| SCHENK LYNN | Director | May 02, 2012 | Option Exercise | $53.43 | 5,975 | 319,244 | 8,875 | May 03, 2012, 04:46 PM |
| SCHENK LYNN | Director | May 02, 2012 | Sale | $135.00 | 5,975 | 806,625 | 2,900 | May 03, 2012, 04:46 PM |
| SCHENK LYNN | Director | May 02, 2012 | Sale | $135.00 | 8,480 | 1,144,800 | 7,100 | May 03, 2012, 04:46 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | May 02, 2012 | Option Exercise | $44.73 | 20,000 | 894,600 | 30,185 | May 03, 2012, 04:34 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | May 02, 2012 | Sale | $135.00 | 20,000 | 2,700,000 | 10,185 | May 03, 2012, 04:34 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Apr 25, 2012 | Option Exercise | $44.73 | 16,764 | 749,854 | 26,949 | Apr 26, 2012, 03:44 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Apr 25, 2012 | Sale | $130.00 | 16,764 | 2,179,320 | 10,185 | Apr 26, 2012, 03:44 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Apr 04, 2012 | Option Exercise | $44.73 | 3,236 | 144,746 | 13,421 | Apr 06, 2012, 03:28 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Apr 04, 2012 | Sale | $130.00 | 3,236 | 420,680 | 10,185 | Apr 06, 2012, 03:28 PM |
| PANGIA ROBERT W | Director | Mar 08, 2012 | Option Exercise | $35.21 | 7,500 | 264,050 | 21,578 | Mar 12, 2012, 03:02 PM |
| PANGIA ROBERT W | Director | Mar 08, 2012 | Sale | $120.00 | 7,500 | 900,000 | 16,578 | Mar 12, 2012, 03:02 PM |
| Gagnon Robert E. | Vice President, Finance | Feb 29, 2012 | Sale | $115.51 | 717 | 82,821 | 4,356 | Mar 01, 2012, 03:23 PM |
| Gagnon Robert E. | Vice President, Finance | Feb 28, 2012 | Sale | $115.03 | 835 | 96,050 | 4,716 | Mar 01, 2012, 03:23 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 27, 2012 | Sale | $115.43 | 4,255 | 491,155 | 12,302 | Feb 28, 2012, 04:01 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 23, 2012 | Option Exercise | $116.70 | 1,413 | 164,897 | 19,186 | Feb 27, 2012, 04:20 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 24, 2012 | Option Exercise | $116.39 | 2,601 | 302,730 | 15,747 | Feb 27, 2012, 04:20 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 24, 2012 | Sale | $115.53 | 2,145 | 247,812 | 17,447 | Feb 27, 2012, 04:20 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 24, 2012 | Option Exercise | $116.39 | 1,578 | 183,663 | 13,506 | Feb 27, 2012, 04:19 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 23, 2012 | Option Exercise | $116.70 | 1,085 | 126,619 | 14,291 | Feb 27, 2012, 04:19 PM |
| Gagnon Robert E. | Vice President, Finance | Feb 24, 2012 | Option Exercise | $116.39 | 334 | 38,874 | 5,719 | Feb 27, 2012, 04:18 PM |
| Gagnon Robert E. | Vice President, Finance | Feb 23, 2012 | Option Exercise | $116.70 | 388 | 45,280 | 5,885 | Feb 27, 2012, 04:18 PM |
| Gagnon Robert E. | Vice President, Finance | Feb 24, 2012 | Option Exercise | $49.65 | 1,054 | 52,331 | 6,939 | Feb 27, 2012, 04:18 PM |
| Gagnon Robert E. | Vice President, Finance | Feb 24, 2012 | Sale | $115.53 | 1,054 | 121,769 | 5,885 | Feb 27, 2012, 04:18 PM |
| Clancy Paul J | Executive VP and CFO | Feb 24, 2012 | Option Exercise | $116.39 | 2,786 | 324,263 | 25,012 | Feb 27, 2012, 04:17 PM |
| Clancy Paul J | Executive VP and CFO | Feb 23, 2012 | Option Exercise | $116.70 | 1,786 | 208,426 | 26,398 | Feb 27, 2012, 04:17 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 15, 2011 | Option Exercise | $104.00 | 8,791 | 914,264 | 54,374 | Feb 22, 2012, 12:03 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 14, 2012 | Sale | $118.61 | 1,247 | 147,907 | 0 | Feb 16, 2012, 02:39 PM |
| Gagnon Robert E. | Vice President, Finance | Feb 14, 2012 | Sale | $118.61 | 560 | 66,422 | 5,050 | Feb 16, 2012, 02:37 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 13, 2012 | Sale | $118.01 | 2,842 | 335,384 | 16,777 | Feb 14, 2012, 03:58 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 09, 2012 | Option Exercise | $117.78 | 579 | 68,195 | 1,247 | Feb 14, 2012, 03:57 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 09, 2012 | Option Exercise | $117.78 | 1,504 | 177,141 | 12,776 | Feb 13, 2012, 04:28 PM |
| Gagnon Robert E. | Vice President, Finance | Feb 09, 2012 | Option Exercise | $117.78 | 301 | 35,452 | 5,610 | Feb 13, 2012, 04:27 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 09, 2012 | Option Exercise | $117.78 | 1,257 | 148,049 | 19,619 | Feb 13, 2012, 04:26 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 10, 2012 | Option Exercise | $118.14 | 7,007 | 827,807 | 66,283 | Feb 13, 2012, 04:24 PM |
| Clancy Paul J | Executive VP and CFO | Feb 09, 2012 | Option Exercise | $117.78 | 1,957 | 230,495 | 23,903 | Feb 13, 2012, 04:21 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 06, 2012 | Sale | $121.03 | 3,110 | 376,403 | 0 | Feb 08, 2012, 03:07 PM |
| Clancy Paul J | Executive VP and CFO | Feb 01, 2012 | Option Exercise | $52.95 | 21,400 | 1,133,088 | 42,568 | Feb 03, 2012, 02:56 PM |
| Clancy Paul J | Executive VP and CFO | Feb 01, 2012 | Sale | $120.00 | 21,400 | 2,568,000 | 29,568 | Feb 03, 2012, 02:56 PM |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 01, 2012 | Option Exercise | $121.26 | 1,656 | 200,807 | 3,906 | Feb 03, 2012, 02:55 PM |
| Holtzman Steven H | EVP Corp Devel and Strategy | Feb 01, 2012 | Option Exercise | $121.26 | 1,658 | 201,049 | 3,501 | Feb 03, 2012, 02:54 PM |
| Granata Francesco | EVP Global Commercial Operatio | Feb 01, 2012 | Option Exercise | $121.26 | 1,669 | 202,383 | 3,529 | Feb 03, 2012, 02:53 PM |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 01, 2012 | Option Exercise | $121.26 | 1,477 | 179,101 | 3,110 | Feb 03, 2012, 02:52 PM |
| LEAMING NANCY | Director | Feb 01, 2012 | Option Exercise | $59.17 | 5,700 | 337,269 | 12,035 | Feb 03, 2012, 02:51 PM |
| LEAMING NANCY | Director | Feb 01, 2012 | Sale | $120.00 | 5,700 | 684,000 | 6,335 | Feb 03, 2012, 02:51 PM |
| LEAMING NANCY | Director | Jan 20, 2012 | Option Exercise | $55.97 | 3,000 | 167,910 | 9,335 | Jan 24, 2012, 03:55 PM |
| LEAMING NANCY | Director | Jan 20, 2012 | Sale | $118.00 | 3,000 | 354,000 | 6,335 | Jan 24, 2012, 03:55 PM |
| LEAMING NANCY | Director | Jan 06, 2012 | Option Exercise | $55.97 | 3,000 | 167,910 | 9,335 | Jan 09, 2012, 03:54 PM |
| LEAMING NANCY | Director | Jan 06, 2012 | Sale | $116.00 | 3,000 | 348,000 | 6,335 | Jan 09, 2012, 03:54 PM |
| Rowinsky Eric K | Director | Jan 06, 2012 | Option Exercise | $59.82 | 12,992 | 777,181 | 20,802 | Jan 09, 2012, 03:52 PM |
| Rowinsky Eric K | Director | Jan 06, 2012 | Sale | $116.00 | 12,992 | 1,507,072 | 9,135 | Jan 09, 2012, 03:52 PM |
| LEAMING NANCY | Director | Jan 03, 2012 | Option Exercise | $55.97 | 4,000 | 223,880 | 10,335 | Jan 04, 2012, 01:27 PM |
| LEAMING NANCY | Director | Jan 03, 2012 | Sale | $114.00 | 4,000 | 456,000 | 6,335 | Jan 04, 2012, 01:27 PM |
| Clancy Paul J | Executive VP and CFO | Jan 03, 2012 | Sale | $112.35 | 20,244 | 2,274,398 | 26,742 | Jan 04, 2012, 01:24 PM |
| SHERWIN STEPHEN A | Director | Dec 19, 2011 | Sale | $110.88 | 2,500 | 277,200 | 6,635 | Dec 20, 2011, 03:10 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Dec 06, 2011 | Sale | $112.31 | 795 | 89,286 | 5,050 | Dec 08, 2011, 02:05 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Dec 01, 2011 | Option Exercise | $116.48 | 371 | 43,214 | 5,845 | Dec 02, 2011, 02:10 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Nov 09, 2011 | Sale | $112.04 | 796 | 89,184 | 6,216 | Nov 14, 2011, 11:26 AM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Nov 02, 2011 | Option Exercise | $113.43 | 371 | 42,083 | 7,012 | Nov 04, 2011, 11:50 AM |
| Cox John | EVP Pharmaceutical Oper & Tech | Nov 01, 2011 | Option Exercise | $72.87 | 2,175 | 158,492 | 11,763 | Nov 03, 2011, 10:52 AM |
| Cox John | EVP Pharmaceutical Oper & Tech | Nov 01, 2011 | Sale | $114.37 | 2,175 | 248,755 | 9,588 | Nov 03, 2011, 10:52 AM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Oct 05, 2011 | Sale | $97.66 | 252 | 24,610 | 7,383 | Oct 07, 2011, 01:48 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Oct 01, 2011 | Option Exercise | $93.15 | 118 | 10,992 | 7,635 | Oct 04, 2011, 06:28 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Oct 03, 2011 | Option Exercise | $49.59 | 778 | 38,581 | 8,413 | Oct 04, 2011, 06:28 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Oct 03, 2011 | Sale | $92.55 | 778 | 72,004 | 7,635 | Oct 04, 2011, 06:28 PM |
| YOUNG WILLIAM | Director | Sep 27, 2011 | Option Exercise | $51.38 | 33,250 | 1,708,441 | 60,109 | Sep 29, 2011, 01:01 PM |
| YOUNG WILLIAM | Director | Sep 27, 2011 | Sale | $96.14 | 33,250 | 3,196,655 | 26,859 | Sep 29, 2011, 01:01 PM |
| LEAMING NANCY | Director | Sep 16, 2011 | Sale | $100.00 | 3,085 | 308,500 | 6,335 | Sep 19, 2011, 05:18 PM |
| YOUNG WILLIAM | Director | Sep 01, 2011 | Option Exercise | $46.68 | 35,000 | 1,633,775 | 61,859 | Sep 02, 2011, 12:45 PM |
| YOUNG WILLIAM | Director | Sep 01, 2011 | Sale | $95.00 | 35,000 | 3,325,000 | 26,859 | Sep 02, 2011, 12:45 PM |
| Posner Brian S | Director | Aug 29, 2011 | Option Exercise | $71.38 | 15,000 | 1,070,700 | 27,630 | Aug 31, 2011, 11:44 AM |
| Posner Brian S | Director | Aug 29, 2011 | Sale | $92.53 | 15,000 | 1,387,894 | 12,630 | Aug 31, 2011, 11:44 AM |
| YOUNG WILLIAM | Director | Aug 29, 2011 | Option Exercise | $68.15 | 10,000 | 681,500 | 36,859 | Aug 31, 2011, 11:42 AM |
| YOUNG WILLIAM | Director | Aug 29, 2011 | Sale | $92.58 | 10,000 | 925,784 | 26,859 | Aug 31, 2011, 11:42 AM |
| ALEXANDER SUSAN H | EVP, General Counsel | Aug 01, 2011 | Option Exercise | $102.90 | 835 | 85,922 | 18,130 | Aug 03, 2011, 11:24 AM |
| ALEXANDER SUSAN H | EVP, General Counsel | Aug 02, 2011 | Sale | $102.04 | 1,165 | 118,877 | 16,965 | Aug 03, 2011, 11:24 AM |
| Clancy Paul J | Executive VP and CFO | Aug 01, 2011 | Option Exercise | $102.90 | 835 | 85,922 | 41,412 | Aug 03, 2011, 11:23 AM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 20, 2011 | Sale | $106.51 | 12,347 | 1,315,035 | 64,164 | Jul 21, 2011, 02:30 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 14, 2011 | Option Exercise | $104.00 | 8,791 | 914,264 | 54,374 | Jul 19, 2011, 04:29 PM |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 15, 2011 | Option Exercise | $104.00 | 8,911 | 926,744 | 66,804 | Jul 19, 2011, 04:29 PM |
| Granata Francesco | EVP Global Commercial Operatio | Jul 01, 2011 | Sale | $107.52 | 2,901 | 311,918 | 0 | Jul 01, 2011, 01:51 PM |
| LEAMING NANCY | Director | Jun 14, 2011 | Sale | $92.62 | 2,300 | 213,022 | 9,420 | Jun 14, 2011, 05:20 PM |
| Posner Brian S | Director | May 25, 2011 | Option Exercise | $67.25 | 25,975 | 1,746,844 | 35,705 | May 27, 2011, 03:15 PM |
| Posner Brian S | Director | May 25, 2011 | Sale | $94.09 | 25,975 | 2,444,027 | 22,900 | May 27, 2011, 03:15 PM |
| LEAMING NANCY | Director | May 26, 2011 | Option Exercise | $55.51 | 33,175 | 1,841,628 | 41,995 | May 27, 2011, 03:13 PM |
| LEAMING NANCY | Director | May 26, 2011 | Sale | $93.05 | 33,175 | 3,087,085 | 13,451 | May 27, 2011, 03:13 PM |
| PANGIA ROBERT W | Director | May 26, 2011 | Option Exercise | $56.88 | 15,000 | 853,200 | 29,080 | May 27, 2011, 03:11 PM |
| PANGIA ROBERT W | Director | May 26, 2011 | Sale | $93.11 | 15,000 | 1,396,647 | 16,280 | May 27, 2011, 03:11 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | May 06, 2011 | Sale | $96.13 | 967 | 92,960 | 7,753 | May 09, 2011, 04:38 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | May 03, 2011 | Option Exercise | $97.99 | 450 | 44,095 | 8,935 | May 04, 2011, 02:53 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | May 04, 2011 | Sale | $96.03 | 215 | 20,646 | 8,720 | May 04, 2011, 02:53 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | May 03, 2011 | Option Exercise | $97.99 | 765 | 74,962 | 9,588 | May 04, 2011, 02:51 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | May 01, 2011 | Option Exercise | $97.65 | 101 | 9,863 | 9,385 | May 03, 2011, 01:03 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | May 02, 2011 | Sale | $97.20 | 20,993 | 2,040,497 | 35,834 | May 03, 2011, 01:01 PM |
| Clancy Paul J | Executive VP and CFO | Apr 28, 2011 | Option Exercise | $41.18 | 14,766 | 608,119 | 57,202 | Apr 29, 2011, 03:03 PM |
| Clancy Paul J | Executive VP and CFO | Apr 28, 2011 | Sale | $98.91 | 19,716 | 1,950,088 | 48,497 | Apr 29, 2011, 03:03 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Apr 21, 2011 | Option Exercise | $72.87 | 4,350 | 316,985 | 14,703 | Apr 25, 2011, 02:02 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Apr 21, 2011 | Sale | $100.00 | 4,350 | 435,000 | 10,353 | Apr 25, 2011, 02:02 PM |
| SCHENK LYNN | Director | Apr 20, 2011 | Option Exercise | $61.84 | 37,275 | 2,304,947 | 35,255 | Apr 21, 2011, 04:41 PM |
| SCHENK LYNN | Director | Apr 20, 2011 | Sale | $85.22 | 37,275 | 3,176,461 | 7,980 | Apr 21, 2011, 04:41 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Apr 13, 2011 | Option Exercise | $56.73 | 36,234 | 2,055,646 | 46,587 | Apr 15, 2011, 11:50 AM |
| Cox John | EVP Pharmaceutical Oper & Tech | Apr 13, 2011 | Sale | $80.00 | 36,234 | 2,898,720 | 10,353 | Apr 15, 2011, 11:50 AM |
| Cox John | EVP Pharmaceutical Oper & Tech | Apr 11, 2011 | Option Exercise | $47.92 | 6,900 | 330,648 | 17,253 | Apr 13, 2011, 10:14 AM |
| Cox John | EVP Pharmaceutical Oper & Tech | Apr 11, 2011 | Sale | $78.00 | 6,900 | 538,200 | 10,353 | Apr 13, 2011, 10:14 AM |
| Clancy Paul J | Executive VP and CFO | Mar 05, 2011 | Option Exercise | $71.15 | 25,888 | 1,841,931 | 47,197 | Apr 08, 2011, 10:38 AM |
| Clancy Paul J | Executive VP and CFO | Mar 05, 2011 | Option Exercise | $58.99 | 28,750 | 1,695,963 | 73,085 | Apr 08, 2011, 10:38 AM |
| Cox John | EVP Pharmaceutical Oper & Tech | Mar 31, 2011 | Option Exercise | $43.50 | 2,840 | 123,540 | 12,658 | Apr 01, 2011, 03:20 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Mar 31, 2011 | Sale | $73.00 | 2,840 | 207,320 | 9,818 | Apr 01, 2011, 03:20 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Mar 01, 2011 | Option Exercise | $49.65 | 6,250 | 310,313 | 23,962 | Mar 03, 2011, 03:17 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Mar 01, 2011 | Sale | $68.62 | 6,250 | 428,875 | 17,712 | Mar 03, 2011, 03:17 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Mar 02, 2011 | Sale | $70.10 | 7,511 | 526,552 | 13,633 | Mar 03, 2011, 03:17 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Mar 02, 2011 | Sale | $70.10 | 4,041 | 283,259 | 12,401 | Mar 03, 2011, 03:10 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Mar 02, 2011 | Sale | $70.02 | 1,402 | 98,164 | 10,788 | Mar 03, 2011, 03:08 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 24, 2011 | Option Exercise | $67.26 | 1,980 | 133,175 | 40,953 | Feb 28, 2011, 03:41 PM |
| Clancy Paul J | Executive VP and CFO | Feb 24, 2011 | Option Exercise | $67.26 | 2,164 | 145,551 | 45,401 | Feb 28, 2011, 03:39 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Feb 24, 2011 | Option Exercise | $67.26 | 335 | 22,532 | 11,056 | Feb 28, 2011, 03:36 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Feb 24, 2011 | Option Exercise | $67.26 | 2,156 | 145,013 | 18,707 | Feb 28, 2011, 03:34 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 24, 2011 | Option Exercise | $67.26 | 1,202 | 80,847 | 14,463 | Feb 28, 2011, 03:32 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 23, 2011 | Option Exercise | $66.76 | 680 | 45,397 | 15,190 | Feb 25, 2011, 03:56 PM |
| Clancy Paul J | Executive VP and CFO | Feb 23, 2011 | Option Exercise | $66.76 | 1,119 | 74,704 | 46,711 | Feb 25, 2011, 03:55 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Feb 23, 2011 | Option Exercise | $66.76 | 320 | 21,363 | 11,284 | Feb 25, 2011, 03:54 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Feb 24, 2011 | Option Exercise | $49.65 | 1,054 | 52,331 | 12,277 | Feb 25, 2011, 03:54 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Feb 24, 2011 | Sale | $66.99 | 1,054 | 70,606 | 11,223 | Feb 25, 2011, 03:54 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Feb 23, 2011 | Option Exercise | $66.76 | 1,598 | 106,682 | 20,171 | Feb 25, 2011, 03:53 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Feb 25, 2011 | Option Exercise | $49.31 | 9,725 | 479,540 | 29,593 | Feb 25, 2011, 03:53 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Feb 25, 2011 | Sale | $68.20 | 9,725 | 663,245 | 19,868 | Feb 25, 2011, 03:53 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 23, 2011 | Option Exercise | $66.76 | 999 | 66,693 | 42,128 | Feb 25, 2011, 03:51 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Feb 17, 2011 | Sale | $67.10 | 732 | 49,115 | 10,537 | Feb 18, 2011, 03:09 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Feb 17, 2011 | Sale | $67.08 | 3,194 | 214,242 | 16,436 | Feb 18, 2011, 03:07 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 17, 2011 | Sale | $67.08 | 1,843 | 123,620 | 13,603 | Feb 18, 2011, 03:06 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Feb 12, 2011 | Option Exercise | $65.83 | 1,486 | 97,823 | 19,630 | Feb 15, 2011, 02:31 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Feb 12, 2011 | Option Exercise | $65.83 | 341 | 22,448 | 11,269 | Feb 15, 2011, 02:29 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 12, 2011 | Option Exercise | $65.83 | 910 | 59,905 | 15,446 | Feb 15, 2011, 02:27 PM |
| Clancy Paul J | Executive VP and CFO | Feb 12, 2011 | Option Exercise | $65.83 | 1,686 | 110,989 | 44,097 | Feb 15, 2011, 02:26 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Feb 12, 2011 | Option Exercise | $65.83 | 1,515 | 99,732 | 39,793 | Feb 15, 2011, 02:24 PM |
| Granata Francesco | EVP Global Commercial Operatio | Feb 01, 2011 | Option Exercise | $65.49 | 1,385 | 90,704 | 3,162 | Feb 03, 2011, 05:14 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Jan 20, 2011 | Option Exercise | $49.65 | 6,250 | 310,313 | 27,366 | Jan 24, 2011, 02:59 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Jan 20, 2011 | Sale | $68.62 | 6,250 | 428,875 | 21,116 | Jan 24, 2011, 02:59 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Jan 04, 2011 | Option Exercise | $46.07 | 4,307 | 198,415 | 12,514 | Jan 05, 2011, 02:45 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Jan 04, 2011 | Sale | $66.57 | 5,103 | 339,690 | 10,814 | Jan 05, 2011, 02:45 PM |
| YOUNG WILLIAM | Director | Dec 31, 2010 | Option Exercise | $67.05 | 13,256 | 888,815 | 21,059 | Jan 04, 2011, 03:58 PM |
| YOUNG WILLIAM | Director | Dec 31, 2010 | Option Exercise | $59.25 | 15,000 | 888,750 | 34,315 | Jan 04, 2011, 03:58 PM |
| SCHENK LYNN | Director | Dec 30, 2010 | Option Exercise | $59.25 | 15,000 | 888,750 | 22,980 | Jan 03, 2011, 09:57 AM |
| SCHENK LYNN | Director | Dec 30, 2010 | Sale | $66.80 | 15,000 | 1,001,988 | 7,980 | Jan 03, 2011, 09:57 AM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Dec 17, 2010 | Option Exercise | $49.31 | 19,450 | 959,080 | 40,566 | Dec 21, 2010, 03:32 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Dec 17, 2010 | Sale | $68.20 | 19,450 | 1,326,490 | 21,116 | Dec 21, 2010, 03:32 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Dec 06, 2010 | Sale | $66.53 | 796 | 52,957 | 11,610 | Dec 07, 2010, 05:14 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Dec 03, 2010 | Option Exercise | $44.24 | 1,907 | 84,366 | 23,023 | Dec 07, 2010, 05:13 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Dec 07, 2010 | Option Exercise | $44.24 | 28,093 | 1,242,834 | 49,209 | Dec 07, 2010, 05:13 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Dec 07, 2010 | Sale | $67.20 | 28,093 | 1,887,850 | 21,116 | Dec 07, 2010, 05:13 PM |
| SCHNEIER CRAIG ERIC | EVP, HR, Public Affairs & Comm | Dec 03, 2010 | Sale | $67.20 | 1,907 | 128,150 | 21,116 | Dec 07, 2010, 05:13 PM |
| Gagnon Robert E. | Chief Acct Officer VP & Contr | Dec 01, 2010 | Option Exercise | $65.37 | 371 | 24,252 | 12,406 | Dec 03, 2010, 01:46 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Nov 09, 2010 | Sale | $62.87 | 773 | 48,597 | 16,356 | Nov 10, 2010, 02:21 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Nov 09, 2010 | Sale | $62.87 | 773 | 48,597 | 16,356 | Nov 10, 2010, 02:21 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Nov 01, 2010 | Option Exercise | $62.55 | 360 | 22,518 | 17,894 | Nov 03, 2010, 01:50 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Nov 01, 2010 | Option Exercise | $62.55 | 360 | 22,518 | 17,894 | Nov 03, 2010, 01:50 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Nov 02, 2010 | Sale | $63.04 | 765 | 48,228 | 17,129 | Nov 03, 2010, 01:50 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Nov 02, 2010 | Sale | $63.04 | 765 | 48,228 | 17,129 | Nov 03, 2010, 01:50 PM |
| PANGIA ROBERT W | Director | Oct 28, 2010 | Option Exercise | $59.25 | 15,000 | 888,750 | 29,080 | Oct 29, 2010, 02:27 PM |
| PANGIA ROBERT W | Director | Oct 28, 2010 | Sale | $64.00 | 15,000 | 960,000 | 14,080 | Oct 29, 2010, 02:27 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Oct 28, 2010 | Option Exercise | $33.97 | 6,900 | 234,393 | 25,154 | Oct 29, 2010, 02:25 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Oct 28, 2010 | Option Exercise | $33.97 | 6,900 | 234,393 | 25,154 | Oct 29, 2010, 02:25 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Oct 28, 2010 | Sale | $63.00 | 6,900 | 434,700 | 18,254 | Oct 29, 2010, 02:25 PM |
| Cox John | EVP Pharmaceutical Oper & Tech | Oct 28, 2010 | Sale | $63.00 | 6,900 | 434,700 | 18,254 | Oct 29, 2010, 02:25 PM |
| MacLean Michael F | SVP, Chief Accounting Officer | Oct 01, 2010 | Option Exercise | $56.53 | 953 | 53,873 | 10,681 | Oct 04, 2010, 04:14 PM |
| Clancy Paul J | Executive VP and CFO | Sep 04, 2010 | Option Exercise | $56.24 | 1,114 | 62,651 | 45,783 | Sep 07, 2010, 04:05 PM |
| DORSA CAROLINE | Director | Aug 13, 2010 | Buy | $56.41 | 177 | 9,985 | 8,243 | Aug 17, 2010, 04:35 PM |
| MacLean Michael F | SVP, Chief Accounting Officer | Aug 02, 2010 | Sale | $56.85 | 9,542 | 542,457 | 20,494 | Aug 03, 2010, 04:03 PM |
| MacLean Michael F | SVP, Chief Accounting Officer | Aug 02, 2010 | Sale | $56.85 | 9,542 | 542,457 | 20,494 | Aug 03, 2010, 04:03 PM |
| Clancy Paul J | Executive VP and CFO | Aug 01, 2010 | Option Exercise | $55.88 | 835 | 46,660 | 46,897 | Aug 03, 2010, 04:01 PM |
| ALEXANDER SUSAN H | EVP, General Counsel | Aug 01, 2010 | Option Exercise | $55.88 | 835 | 46,660 | 41,308 | Aug 03, 2010, 04:00 PM |
| DORSA CAROLINE | Director | Jul 30, 2010 | Buy | $54.57 | 183 | 9,986 | 8,066 | Aug 03, 2010, 03:58 PM |
| Owner | Relationship | Date | Transaction | Value($) |
| Vounatsos Michel | Chief Executive Officer | May 02, 2019 | Option Exercise | 151,682 |
| DENNER ALEXANDER J | Director | Apr 30, 2019 | Buy | 11,540,904 |
| DENNER ALEXANDER J | Director | May 02, 2019 | Buy | 8,787,120 |
| DENNER ALEXANDER J | Director | May 01, 2019 | Buy | 6,883,800 |
| Vounatsos Michel | Chief Executive Officer | May 01, 2019 | Buy | 1,007,169 |
| PANGIA ROBERT W | Director | Mar 18, 2019 | Option Exercise | 319,273 |
| PANGIA ROBERT W | Director | Mar 18, 2019 | Sale | 2,008,755 |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Mar 01, 2019 | Option Exercise | 219,838 |
| ALEXANDER SUSAN H | EVP Chief Legal Officer & Sec. | Feb 22, 2019 | Option Exercise | 1,336,781 |
| ALEXANDER SUSAN H | EVP Chief Legal Officer & Sec. | Feb 22, 2019 | Option Exercise | 310,285 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 22, 2019 | Option Exercise | 240,419 |
| Vounatsos Michel | Chief Executive Officer | Feb 15, 2019 | Option Exercise | 778,916 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 15, 2019 | Option Exercise | 195,062 |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Feb 15, 2019 | Option Exercise | 214,035 |
| Ehlers Michael D | EVP, Research and Development | Feb 15, 2019 | Option Exercise | 249,320 |
| ALEXANDER SUSAN H | EVP Chief Legal Officer & Sec. | Feb 15, 2019 | Option Exercise | 249,320 |
| Vounatsos Michel | Chief Executive Officer | Feb 12, 2019 | Option Exercise | 837,545 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 12, 2019 | Option Exercise | 804,325 |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Feb 12, 2019 | Option Exercise | 293,556 |
| Gregory Ginger | EVP, Human Resources | Feb 12, 2019 | Option Exercise | 176,006 |
| Ehlers Michael D | EVP, Research and Development | Feb 12, 2019 | Option Exercise | 404,718 |
| ALEXANDER SUSAN H | EVP Chief Legal Officer & Sec. | Feb 12, 2019 | Option Exercise | 326,138 |
| DENNER ALEXANDER J | Director | Jan 31, 2019 | Buy | 8,527,393 |
| DENNER ALEXANDER J | Director | Jan 30, 2019 | Buy | 9,745,851 |
| DENNER ALEXANDER J | Director | Feb 01, 2019 | Buy | 2,299,163 |
| CAPELLO JEFFREY D | EVP & Chief Financial Officer | Jan 02, 2019 | Option Exercise | 126,142 |
| Guindo Chirfi | EVP Glob. Mkt Acc & Cust Innov | Dec 01, 2018 | Option Exercise | 136,491 |
| Ehlers Michael D | EVP, Research and Development | Sep 26, 2018 | Sale | 350,000 |
| Gregory Ginger | EVP, Human Resources | Aug 01, 2018 | Option Exercise | 56,082 |
| Ehlers Michael D | EVP, Research and Development | Jun 01, 2018 | Option Exercise | 319,669 |
| Vounatsos Michel | Chief Executive Officer | May 02, 2018 | Option Exercise | 205,598 |
| DENNER ALEXANDER J | Director | Apr 25, 2018 | Buy | 12,955,680 |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Mar 01, 2018 | Option Exercise | 181,269 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 27, 2018 | Sale | 75,325 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 23, 2018 | Option Exercise | 60,898 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 23, 2018 | Sale | 266,444 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 23, 2018 | Option Exercise | 8,198 |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Feb 23, 2018 | Option Exercise | 111,549 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 22, 2018 | Option Exercise | 207,057 |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Feb 22, 2018 | Option Exercise | 207,057 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 22, 2018 | Option Exercise | 16,519 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 20, 2018 | Sale | 216,956 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 15, 2018 | Sale | 386,712 |
| Vounatsos Michel | Chief Executive Officer | Feb 15, 2018 | Option Exercise | 561,936 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 15, 2018 | Option Exercise | 178,430 |
| Ehlers Michael D | EVP, Research and Development | Feb 15, 2018 | Option Exercise | 152,384 |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Feb 15, 2018 | Option Exercise | 152,684 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 15, 2018 | Option Exercise | 16,765 |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Feb 15, 2018 | Option Exercise | 132,326 |
| Sandrock Alfred | EVP, Chief Medical Officer | Feb 12, 2018 | Option Exercise | 416,685 |
| PANGIA ROBERT W | Director | Jan 09, 2018 | Option Exercise | 337,265 |
| PANGIA ROBERT W | Director | Jan 09, 2018 | Sale | 1,922,519 |
| Vounatsos Michel | Chief Executive Officer | Dec 29, 2017 | Buy | 250,029 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Dec 01, 2017 | Option Exercise | 50,138 |
| DENNER ALEXANDER J | Director | Nov 28, 2017 | Buy | 6,322,400 |
| DENNER ALEXANDER J | Director | Nov 29, 2017 | Buy | 3,198,400 |
| DENNER ALEXANDER J | Director | Aug 31, 2017 | Option Exercise | 295,350 |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Jul 25, 2017 | Sale | 1,442,510 |
| ALEXANDER SUSAN H | EVP Chief Legal Corp Svc & Sec | Jul 19, 2017 | Sale | 2,211,030 |
| Posner Brian S | Director | Jun 09, 2017 | Sale | 277,840 |
| Ehlers Michael D | EVP, Research and Development | Jun 01, 2017 | Option Exercise | 188,528 |
| Vounatsos Michel | Chief Executive Officer | May 02, 2017 | Option Exercise | 153,036 |
| Vounatsos Michel | Chief Executive Officer | May 01, 2017 | Buy | 380,433 |
| DENNER ALEXANDER J | Director | Apr 27, 2017 | Buy | 20,569,476 |
| Clancy Paul J | Executive VP and CFO | Apr 25, 2017 | Sale | 2,868,680 |
| Clancy Paul J | Executive VP and CFO | Mar 13, 2017 | Sale | 2,883,721 |
| McKenzie Paul | EVP Pharmaceutical Oper & Tech | Mar 01, 2017 | Option Exercise | 46,042 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Mar 01, 2017 | Sale | 282,238 |
| Clancy Paul J | Executive VP and CFO | Feb 28, 2017 | Option Exercise | 853,135 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 28, 2017 | Option Exercise | 829,217 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 28, 2017 | Option Exercise | 670,996 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 28, 2017 | Option Exercise | 25,386 |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Feb 28, 2017 | Option Exercise | 211,542 |
| DiPietro Kenneth | EVP Human Resources | Feb 28, 2017 | Option Exercise | 684,399 |
| PANGIA ROBERT W | Director | Jan 09, 2017 | Option Exercise | 284,599 |
| PANGIA ROBERT W | Director | Jan 09, 2017 | Sale | 1,609,876 |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Dec 01, 2016 | Option Exercise | 50,578 |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Dec 01, 2016 | Sale | 14,233 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Dec 01, 2016 | Option Exercise | 15,676 |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Oct 04, 2016 | Sale | 81,728 |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Oct 01, 2016 | Option Exercise | 591,001 |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Oct 03, 2016 | Sale | 118,940 |
| DORSA CAROLINE | Director | Sep 22, 2016 | Option Exercise | 1,478,855 |
| DORSA CAROLINE | Director | Sep 22, 2016 | Sale | 8,656,980 |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 21, 2016 | Sale | 43,960 |
| Koppel Adam | EVP, Strategy and Bus. Dev. | Jun 06, 2016 | Sale | 160,950 |
| Koppel Adam | EVP, Strategy and Bus. Dev. | Jun 02, 2016 | Option Exercise | 154,716 |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 03, 2016 | Sale | 244,180 |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 01, 2016 | Sale | 140,241 |
| SCANGOS GEORGE A | Chief Executive Officer | May 31, 2016 | Sale | 976,720 |
| SCANGOS GEORGE A | Chief Executive Officer | May 25, 2016 | Sale | 43,960 |
| SCANGOS GEORGE A | Chief Executive Officer | May 02, 2016 | Sale | 133,798 |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2016 | Option Exercise | 31,074 |
| Koppel Adam | EVP, Strategy and Bus. Dev. | Apr 06, 2016 | Sale | 28,050 |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 06, 2016 | Sale | 43,960 |
| Artavanis-Tsakonas Spyridon | EVP, Chief Scientific Officer | Apr 02, 2016 | Option Exercise | 119,588 |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 01, 2016 | Sale | 126,050 |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 01, 2016 | Sale | 127,287 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 25, 2016 | Sale | 47,928 |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Feb 25, 2016 | Sale | 22,000 |
| Clancy Paul J | Executive VP and CFO | Feb 23, 2016 | Option Exercise | 70,704 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 23, 2016 | Option Exercise | 5,698 |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Feb 23, 2016 | Option Exercise | 12,432 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 23, 2016 | Option Exercise | 77,697 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 23, 2016 | Option Exercise | 98,934 |
| Koppel Adam | EVP, Strategy and Bus. Dev. | Feb 23, 2016 | Option Exercise | 25,381 |
| DiPietro Kenneth | EVP Human Resources | Feb 23, 2016 | Option Exercise | 77,697 |
| Holtzman Steven H | EVP Corporate Development | Feb 23, 2016 | Option Exercise | 70,704 |
| Karaboutis Adriana | EVP, Tech, Bus. Sol & Corp Aff | Feb 23, 2016 | Option Exercise | 41,956 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 23, 2016 | Option Exercise | 42,474 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 23, 2016 | Option Exercise | 361,291 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 17, 2016 | Sale | 124,750 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 17, 2016 | Sale | 184,948 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 12, 2016 | Option Exercise | 2,920,904 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 12, 2016 | Option Exercise | 383,685 |
| DiPietro Kenneth | EVP Human Resources | Feb 12, 2016 | Option Exercise | 338,444 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 12, 2016 | Option Exercise | 6,428 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 12, 2016 | Option Exercise | 451,671 |
| Holtzman Steven H | EVP Corporate Development | Feb 12, 2016 | Option Exercise | 324,847 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 12, 2016 | Option Exercise | 328,308 |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Feb 12, 2016 | Option Exercise | 87,021 |
| Clancy Paul J | Executive VP and CFO | Feb 12, 2016 | Option Exercise | 420,027 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 09, 2016 | Option Exercise | 1,326,197 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 08, 2016 | Option Exercise | 106,828 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Feb 09, 2016 | Sale | 210,052 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 08, 2016 | Option Exercise | 206,133 |
| Clancy Paul J | Executive VP and CFO | Feb 08, 2016 | Option Exercise | 262,556 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 08, 2016 | Option Exercise | 332,019 |
| Holtzman Steven H | EVP Corporate Development | Feb 08, 2016 | Option Exercise | 223,185 |
| DiPietro Kenneth | EVP Human Resources | Feb 01, 2016 | Option Exercise | 222,041 |
| DiPietro Kenneth | EVP Human Resources | Feb 01, 2016 | Option Exercise | 674,328 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Dec 03, 2015 | Option Exercise | 108,248 |
| Sandrock Alfred | EVP CMO Neuro & Neurodegenerat | Dec 04, 2015 | Sale | 122,157 |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Dec 01, 2015 | Option Exercise | 49,597 |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Dec 02, 2015 | Sale | 13,879 |
| DENNER ALEXANDER J | Director | Oct 23, 2015 | Buy | 27,676,999 |
| DENNER ALEXANDER J | Director | Oct 22, 2015 | Buy | 58,337,997 |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Oct 05, 2015 | Sale | 78,395 |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Oct 01, 2015 | Option Exercise | 478,642 |
| Karaboutis Adriana | EVP, Tech. and Bus. Solutions | Oct 02, 2015 | Sale | 118,169 |
| PAPADOPOULOS STELIOS | Director | Jul 27, 2015 | Buy | 1,523,880 |
| PAPADOPOULOS STELIOS | Director | Jul 27, 2015 | Buy | 1,524,895 |
| Posner Brian S | Director | Jun 22, 2015 | Sale | 195,050 |
| WILLIAMS DOUGLAS E | EVP Research & Development | Jun 19, 2015 | Sale | 1,574,810 |
| Posner Brian S | Director | Jun 15, 2015 | Sale | 154,656 |
| Koppel Adam | SVP, Chief Strategy Officer | Jun 02, 2015 | Option Exercise | 330,252 |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 01, 2015 | Sale | 543,261 |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2015 | Option Exercise | 43,643 |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2015 | Option Exercise | 134,018 |
| SCANGOS GEORGE A | Chief Executive Officer | May 01, 2015 | Sale | 514,182 |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Apr 02, 2015 | Option Exercise | 189,722 |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 01, 2015 | Sale | 576,398 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 27, 2015 | Sale | 184,952 |
| Cox John | EVP Pharmaceutical Oper & Tech | Mar 25, 2015 | Option Exercise | 333,571 |
| Cox John | EVP Pharmaceutical Oper & Tech | Mar 25, 2015 | Sale | 5,393,211 |
| Rowinsky Eric K | Director | Mar 20, 2015 | Option Exercise | 697,920 |
| Rowinsky Eric K | Director | Mar 20, 2015 | Sale | 5,541,825 |
| Rowinsky Eric K | Director | Mar 19, 2015 | Option Exercise | 139,560 |
| Rowinsky Eric K | Director | Mar 19, 2015 | Sale | 1,017,508 |
| Rowinsky Eric K | Director | Mar 17, 2015 | Option Exercise | 279,180 |
| Rowinsky Eric K | Director | Mar 17, 2015 | Sale | 1,985,589 |
| DiPietro Kenneth | EVP Human Resources | Mar 16, 2015 | Sale | 333,614 |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 13, 2015 | Sale | 221,613 |
| SHERWIN STEPHEN A | Director | Mar 10, 2015 | Option Exercise | 358,920 |
| SHERWIN STEPHEN A | Director | Mar 10, 2015 | Sale | 2,458,020 |
| Rowinsky Eric K | Director | Mar 09, 2015 | Option Exercise | 279,120 |
| Rowinsky Eric K | Director | Mar 09, 2015 | Sale | 1,946,795 |
| PANGIA ROBERT W | Director | Mar 10, 2015 | Option Exercise | 172,954 |
| PANGIA ROBERT W | Director | Mar 10, 2015 | Sale | 1,498,578 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 01, 2015 | Option Exercise | 1,157,501 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 02, 2015 | Sale | 1,299,715 |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 02, 2015 | Sale | 338,803 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 12, 2015 | Option Exercise | 3,137 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 19, 2015 | Sale | 215,358 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 17, 2015 | Sale | 321,016 |
| Holtzman Steven H | EVP Corporate Development | Feb 17, 2015 | Sale | 828,026 |
| DiPietro Kenneth | EVP Human Resources | Feb 17, 2015 | Sale | 462,263 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 17, 2015 | Sale | 162,648 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 12, 2015 | Option Exercise | 4,754,334 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 12, 2015 | Option Exercise | 7,842 |
| Holtzman Steven H | EVP Corporate Development | Feb 12, 2015 | Option Exercise | 671,292 |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Feb 12, 2015 | Option Exercise | 154,491 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 12, 2015 | Option Exercise | 296,827 |
| Clancy Paul J | Executive VP and CFO | Feb 12, 2015 | Option Exercise | 794,415 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 12, 2015 | Option Exercise | 690,506 |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 12, 2015 | Option Exercise | 960,669 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 12, 2015 | Option Exercise | 696,387 |
| DiPietro Kenneth | EVP Human Resources | Feb 12, 2015 | Option Exercise | 695,211 |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 12, 2015 | Option Exercise | 665,411 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 10, 2015 | Sale | 455,039 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 09, 2015 | Option Exercise | 1,960,587 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 10, 2015 | Option Exercise | 3,505,198 |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 08, 2015 | Option Exercise | 656,868 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 08, 2015 | Option Exercise | 328,836 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 09, 2015 | Option Exercise | 731,053 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 09, 2015 | Option Exercise | 270,275 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 08, 2015 | Option Exercise | 169,242 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 09, 2015 | Sale | 340,731 |
| Holtzman Steven H | EVP Corporate Development | Feb 08, 2015 | Option Exercise | 512,550 |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 09, 2015 | Option Exercise | 341,317 |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 08, 2015 | Option Exercise | 354,966 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 09, 2015 | Option Exercise | 877,105 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 08, 2015 | Option Exercise | 617,874 |
| Clancy Paul J | Executive VP and CFO | Feb 08, 2015 | Option Exercise | 459,486 |
| Clancy Paul J | Executive VP and CFO | Feb 09, 2015 | Option Exercise | 877,105 |
| DiPietro Kenneth | EVP Human Resources | Feb 02, 2015 | Sale | 644,234 |
| DiPietro Kenneth | EVP Human Resources | Feb 01, 2015 | Option Exercise | 314,052 |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 01, 2015 | Option Exercise | 801,280 |
| Holtzman Steven H | EVP Corporate Development | Feb 01, 2015 | Option Exercise | 801,670 |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Dec 15, 2014 | Sale | 686,417 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Dec 03, 2014 | Option Exercise | 136,505 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Dec 04, 2014 | Sale | 152,187 |
| Holtzman Steven H | EVP Corporate Development | Dec 02, 2014 | Sale | 587,052 |
| Holtzman Steven H | EVP Corporate Development | Nov 11, 2014 | Sale | 577,500 |
| SCANGOS GEORGE A | Chief Executive Officer | Nov 03, 2014 | Sale | 361,840 |
| SCANGOS GEORGE A | Chief Executive Officer | Oct 01, 2014 | Sale | 373,003 |
| Holtzman Steven H | EVP Corporate Development | Oct 01, 2014 | Sale | 579,198 |
| SCANGOS GEORGE A | Chief Executive Officer | Sep 02, 2014 | Sale | 389,690 |
| SCANGOS GEORGE A | Chief Executive Officer | Aug 01, 2014 | Sale | 375,545 |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 16, 2014 | Sale | 3,847,149 |
| SCANGOS GEORGE A | Chief Executive Officer | Jul 15, 2014 | Option Exercise | 3,139,344 |
| Posner Brian S | Director | Jun 20, 2014 | Sale | 190,575 |
| Posner Brian S | Director | Jun 13, 2014 | Sale | 217,350 |
| SCANGOS GEORGE A | Chief Executive Officer | Jun 02, 2014 | Sale | 154,362 |
| Holtzman Steven H | EVP Corporate Development | May 19, 2014 | Sale | 353,052 |
| SCANGOS GEORGE A | Chief Executive Officer | May 01, 2014 | Sale | 606,241 |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2014 | Option Exercise | 32,403 |
| COVINO GREGORY F | VP, Chief Accounting Officer | May 01, 2014 | Option Exercise | 99,502 |
| Holtzman Steven H | EVP Corporate Development | Apr 17, 2014 | Sale | 355,311 |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Apr 02, 2014 | Option Exercise | 134,100 |
| PANGIA ROBERT W | Director | Apr 01, 2014 | Option Exercise | 297,187 |
| PANGIA ROBERT W | Director | Apr 01, 2014 | Sale | 1,927,625 |
| SCANGOS GEORGE A | Chief Executive Officer | Apr 01, 2014 | Sale | 654,776 |
| Posner Brian S | Director | Mar 31, 2014 | Sale | 890,275 |
| DORSA CAROLINE | Director | Mar 20, 2014 | Option Exercise | 536,400 |
| DORSA CAROLINE | Director | Mar 20, 2014 | Sale | 3,488,812 |
| WILLIAMS DOUGLAS E | EVP Research & Development | Mar 19, 2014 | Sale | 1,234,776 |
| Holtzman Steven H | EVP Corporate Development | Mar 17, 2014 | Sale | 408,827 |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 10, 2014 | Sale | 8,719,378 |
| LEAMING NANCY | Director | Mar 10, 2014 | Sale | 655,300 |
| Kingsley Stuart A | EVP, Global Comm. Operations | Mar 11, 2014 | Sale | 2,838,766 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 04, 2014 | Sale | 1,086,321 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Mar 03, 2014 | Option Exercise | 963,784 |
| SCANGOS GEORGE A | Chief Executive Officer | Mar 03, 2014 | Sale | 987,894 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 26, 2014 | Sale | 358,594 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 23, 2014 | Option Exercise | 326,283 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 23, 2014 | Option Exercise | 426,251 |
| Clancy Paul J | Executive VP and CFO | Feb 23, 2014 | Option Exercise | 700,468 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 23, 2014 | Option Exercise | 625,839 |
| Holtzman Steven H | EVP Corporate Development | Feb 18, 2014 | Sale | 400,694 |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 12, 2014 | Option Exercise | 544,322 |
| Clancy Paul J | Executive VP and CFO | Feb 12, 2014 | Option Exercise | 427,705 |
| Artavanis-Tsakonas Spyridon | SVP, Chief Scientific Officer | Feb 12, 2014 | Option Exercise | 77,207 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 12, 2014 | Option Exercise | 326,270 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 12, 2014 | Option Exercise | 118,556 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 13, 2014 | Sale | 134,478 |
| Holtzman Steven H | EVP Corporate Development | Feb 12, 2014 | Option Exercise | 326,270 |
| COVINO GREGORY F | VP, Chief Accounting Officer | Feb 12, 2014 | Option Exercise | 2,584 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 12, 2014 | Option Exercise | 1,399,732 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 13, 2014 | Sale | 153,970 |
| DiPietro Kenneth | EVP Human Resources | Feb 12, 2014 | Option Exercise | 308,826 |
| DiPietro Kenneth | EVP Human Resources | Feb 13, 2014 | Sale | 408,685 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 12, 2014 | Option Exercise | 342,099 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 11, 2014 | Sale | 655,336 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 11, 2014 | Sale | 771,945 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 10, 2014 | Option Exercise | 2,801,995 |
| SCANGOS GEORGE A | Chief Executive Officer | Feb 09, 2014 | Option Exercise | 1,530,369 |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 09, 2014 | Option Exercise | 271,680 |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 08, 2014 | Option Exercise | 392,216 |
| Clancy Paul J | Executive VP and CFO | Feb 09, 2014 | Option Exercise | 697,974 |
| Clancy Paul J | Executive VP and CFO | Feb 08, 2014 | Option Exercise | 330,370 |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 08, 2014 | Option Exercise | 516,223 |
| Holtzman Steven H | EVP Corporate Development | Feb 08, 2014 | Option Exercise | 402,629 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 09, 2014 | Option Exercise | 187,431 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Feb 08, 2014 | Option Exercise | 133,158 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 08, 2014 | Option Exercise | 258,427 |
| ALEXANDER SUSAN H | EVP, Chief Legal Officer | Feb 09, 2014 | Option Exercise | 550,933 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 09, 2014 | Option Exercise | 697,974 |
| Cox John | EVP Pharmaceutical Oper & Tech | Feb 08, 2014 | Option Exercise | 454,693 |
| DiPietro Kenneth | EVP Human Resources | Feb 04, 2014 | Sale | 494,862 |
| DiPietro Kenneth | EVP Human Resources | Feb 01, 2014 | Option Exercise | 252,613 |
| WILLIAMS DOUGLAS E | EVP Research & Development | Feb 01, 2014 | Option Exercise | 615,588 |
| Kingsley Stuart A | EVP, Global Comm. Operations | Feb 01, 2014 | Option Exercise | 531,801 |
| Holtzman Steven H | EVP Corporate Development | Feb 01, 2014 | Option Exercise | 616,213 |
| Rowinsky Eric K | Director | Jan 21, 2014 | Sale | 626,382 |
| SCHENK LYNN | Director | Jan 15, 2014 | Sale | 297,480 |
| YOUNG WILLIAM | Director | Jan 08, 2014 | Sale | 4,276,590 |
| PANGIA ROBERT W | Director | Jan 06, 2014 | Option Exercise | 297,187 |
| PANGIA ROBERT W | Director | Jan 06, 2014 | Sale | 1,737,687 |
| SHERWIN STEPHEN A | Director | Jan 02, 2014 | Option Exercise | 329,010 |
| SHERWIN STEPHEN A | Director | Jan 02, 2014 | Sale | 1,536,059 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Dec 03, 2013 | Option Exercise | 113,377 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Dec 04, 2013 | Sale | 125,510 |
| SCHENK LYNN | Director | Dec 02, 2013 | Sale | 291,710 |
| Pawlicki Raymond | SVP, Chief Information Officer | Nov 22, 2013 | Option Exercise | 199,800 |
| Pawlicki Raymond | SVP, Chief Information Officer | Nov 22, 2013 | Sale | 1,152,000 |
| SCHENK LYNN | Director | Nov 01, 2013 | Sale | 245,000 |
| SCANGOS GEORGE A | Chief Executive Officer | Nov 01, 2013 | Sale | 549,831 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Oct 22, 2013 | Option Exercise | 910,217 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Oct 22, 2013 | Sale | 3,759,123 |
| SCHENK LYNN | Director | Oct 01, 2013 | Sale | 242,850 |
| SCANGOS GEORGE A | Chief Executive Officer | Oct 01, 2013 | Sale | 543,741 |
| DiPietro Kenneth | EVP Human Resources | Sep 30, 2013 | Sale | 348,480 |
| Clancy Paul J | Executive VP and CFO | Sep 18, 2013 | Option Exercise | 1,329,875 |
| Clancy Paul J | Executive VP and CFO | Sep 18, 2013 | Sale | 6,562,325 |
| Clancy Paul J | Executive VP and CFO | Sep 16, 2013 | Option Exercise | 5,556,895 |
| Clancy Paul J | Executive VP and CFO | Sep 16, 2013 | Sale | 23,596,311 |
| Holtzman Steven H | EVP Corporate Development | Sep 17, 2013 | Sale | 836,669 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Sep 16, 2013 | Option Exercise | 487,563 |
| Sandrock Alfred | Grp SVP, Chief Medical Officer | Sep 16, 2013 | Sale | 2,357,821 |
| Pawlicki Raymond | SVP, Chief Information Officer | Sep 16, 2013 | Option Exercise | 198,360 |
| Pawlicki Raymond | SVP, Chief Information Officer | Sep 16, 2013 | Sale | 952,120 |
| SCHENK LYNN | Director | Sep 11, 2013 | Sale | 211,726 |
| SCANGOS GEORGE A | Chief Executive Officer | Sep 03, 2013 | Sale | 480,042 |
| WILLIAMS DOUGLAS E | EVP Research & Development | Aug 26, 2013 | Sale | 923,168 |