Insider Transactions for AMARIN CORP PLCUK (AMRN)

Owner Relationship Date Transaction Cost # Shares Value($) Total Shares Form 4
THERO JOHN F President and CEO Aug 21, 2019 Option Exercise $2.50 24,999 62,498 2,313,310 Aug 23, 2019, 08:19 PM
THERO JOHN F President and CEO Aug 21, 2019 Option Exercise $1.56 191,997 300,010 2,324,911 Aug 22, 2019, 08:02 PM
STACK DAVID M Director Jul 11, 2019 Option Exercise $2.33 51,991 121,035 51,991 Jul 12, 2019, 08:03 PM
STACK DAVID M Director Jul 11, 2019 Sale $22.28 51,991 1,158,354 0 Jul 12, 2019, 08:03 PM
Zakrzewski Joseph S Director Jul 05, 2019 Option Exercise $9.00 100,000 900,000 184,547 Jul 05, 2019, 09:00 PM
Zakrzewski Joseph S Director Jul 05, 2019 Sale $23.82 100,000 2,381,580 84,547 Jul 05, 2019, 09:00 PM
Kennedy Joseph T General Counsel Jul 01, 2019 Option Exercise $2.57 27,244 69,962 85,446 Jul 03, 2019, 08:01 PM
Kennedy Joseph T General Counsel Jul 01, 2019 Sale $19.52 54,186 1,057,906 31,260 Jul 03, 2019, 08:01 PM
Kalb Michael Wayne SVP and CFO Jul 01, 2019 Option Exercise $2.19 50,000 109,500 70,840 Jul 03, 2019, 08:00 PM
Kalb Michael Wayne SVP and CFO Jul 01, 2019 Sale $19.67 50,000 983,270 20,840 Jul 03, 2019, 08:00 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 02, 2019 Option Exercise $2.50 69,564 173,910 105,915 Jul 03, 2019, 08:00 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 03, 2019 Option Exercise $2.80 29,250 81,900 65,601 Jul 03, 2019, 08:00 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 03, 2019 Sale $22.64 29,250 662,238 36,351 Jul 03, 2019, 08:00 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 02, 2019 Sale $20.73 69,564 1,442,141 55,915 Jul 03, 2019, 08:00 PM
Kennedy Joseph T General Counsel Jun 30, 2019 Option Exercise $19.39 26,495 513,738 58,202 Jul 02, 2019, 08:05 PM
THERO JOHN F President and CEO Jun 30, 2019 Option Exercise $19.39 14,757 286,138 2,132,914 Jul 02, 2019, 08:05 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jun 24, 2019 Option Exercise $2.50 100,000 250,000 149,546 Jun 26, 2019, 08:09 PM
Berg Aaron CHIEF COMMERCIAL OFFICER Jun 24, 2019 Sale $18.59 113,195 2,104,521 36,351 Jun 26, 2019, 08:09 PM
Zakrzewski Joseph S Director Jun 18, 2019 Option Exercise $3.40 100,000 340,000 184,547 Jun 20, 2019, 08:05 PM
Zakrzewski Joseph S Director Jun 18, 2019 Sale $19.02 100,000 1,902,090 84,547 Jun 20, 2019, 08:05 PM
Kennedy Joseph T General Counsel May 31, 2019 Option Exercise $2.57 27,229 69,925 58,489 May 31, 2019, 08:04 PM
Kennedy Joseph T General Counsel May 31, 2019 Sale $17.92 27,229 488,058 31,260 May 31, 2019, 08:04 PM
STACK DAVID M Director May 29, 2019 Option Exercise $3.21 33,799 108,495 33,799 May 31, 2019, 08:02 PM
STACK DAVID M Director May 29, 2019 Sale $18.45 33,799 623,534 0 May 31, 2019, 08:02 PM
STACK DAVID M Director May 17, 2019 Option Exercise $3.21 13,174 42,289 13,174 May 21, 2019, 08:14 PM
STACK DAVID M Director May 17, 2019 Sale $18.00 13,174 237,139 0 May 21, 2019, 08:14 PM
Ketchum Steven B Chief Scientific Officer Apr 30, 2019 Option Exercise $2.33 9,541 22,235 364,033 May 02, 2019, 09:05 PM
Ketchum Steven B Chief Scientific Officer Apr 30, 2019 Sale $18.67 9,541 178,107 354,492 May 02, 2019, 09:05 PM
Kennedy Joseph T General Counsel Apr 30, 2019 Option Exercise $2.57 27,230 69,927 58,490 May 02, 2019, 09:01 PM
Kennedy Joseph T General Counsel Apr 30, 2019 Sale $18.69 27,230 508,839 31,260 May 02, 2019, 09:01 PM
Berg Aaron CHIEF COMMERCIAL OFFICER May 01, 2019 Option Exercise $18.70 12,805 239,454 49,546 May 02, 2019, 08:02 PM
THERO JOHN F President and CEO Mar 31, 2019 Option Exercise $20.76 14,757 306,355 2,110,171 Apr 01, 2019, 08:24 PM
Ketchum Steven B Chief Scientific Officer Apr 01, 2019 Option Exercise $2.33 9,542 22,236 364,034 Apr 01, 2019, 08:22 PM
Ketchum Steven B Chief Scientific Officer Apr 01, 2019 Sale $20.06 9,542 191,392 354,592 Apr 01, 2019, 08:22 PM
Kennedy Joseph T General Counsel Mar 31, 2019 Option Exercise $20.76 26,495 550,036 58,202 Apr 01, 2019, 08:20 PM
Kennedy Joseph T General Counsel Apr 01, 2019 Option Exercise $2.57 27,230 69,926 85,432 Apr 01, 2019, 08:20 PM
Kennedy Joseph T General Counsel Apr 01, 2019 Sale $20.05 54,172 1,086,122 32,372 Apr 01, 2019, 08:20 PM
THERO JOHN F President and CEO Mar 04, 2019 Sale $21.31 250,000 5,327,234 2,158,101 Mar 06, 2019, 08:16 PM
Ekman Lars Director Mar 04, 2019 Option Exercise $2.04 135,377 276,743 135,377 Mar 06, 2019, 08:16 PM
Ekman Lars Director Mar 04, 2019 Sale $21.31 135,377 2,884,905 36,700 Mar 06, 2019, 08:16 PM
Ketchum Steven B Chief Scientific Officer Mar 01, 2019 Option Exercise $2.50 46,000 115,000 400,492 Mar 01, 2019, 08:19 PM
Ketchum Steven B Chief Scientific Officer Feb 28, 2019 Option Exercise $2.33 9,543 22,239 364,035 Mar 01, 2019, 08:19 PM
Ketchum Steven B Chief Scientific Officer Feb 28, 2019 Sale $20.67 9,543 197,249 354,492 Mar 01, 2019, 08:19 PM
Ketchum Steven B Chief Scientific Officer Mar 01, 2019 Sale $22.09 46,000 1,016,275 396,989 Mar 01, 2019, 08:19 PM
Kalb Michael Wayne SVP and CFO Mar 01, 2019 Option Exercise $2.83 100,000 283,350 120,551 Mar 01, 2019, 08:18 PM
Kalb Michael Wayne SVP and CFO Mar 01, 2019 Sale $22.09 100,000 2,209,098 113,427 Mar 01, 2019, 08:18 PM
Kennedy Joseph T General Counsel Feb 28, 2019 Option Exercise $2.57 27,231 69,928 58,491 Mar 01, 2019, 08:17 PM
Kennedy Joseph T General Counsel Feb 28, 2019 Sale $20.72 27,231 564,172 31,260 Mar 01, 2019, 08:17 PM
Zakrzewski Joseph S Director Feb 22, 2019 Option Exercise $8.70 180,625 1,572,312 265,172 Feb 22, 2019, 09:34 PM
Zakrzewski Joseph S Director Feb 22, 2019 Sale $19.90 180,625 3,594,437 84,547 Feb 22, 2019, 09:34 PM
VAN HEEK G JAN Director Feb 22, 2019 Option Exercise $4.46 192,347 857,170 217,550 Feb 22, 2019, 09:33 PM
VAN HEEK G JAN Director Feb 22, 2019 Sale $20.02 203,382 4,071,423 14,168 Feb 22, 2019, 09:33 PM
Peterson Kristine Director Feb 22, 2019 Option Exercise $5.80 163,500 947,730 163,500 Feb 22, 2019, 09:32 PM
Peterson Kristine Director Feb 22, 2019 Sale $20.02 163,500 3,274,038 0 Feb 22, 2019, 09:32 PM
Kalb Michael Wayne SVP and CFO Feb 22, 2019 Option Exercise $2.95 50,000 147,500 70,551 Feb 22, 2019, 09:31 PM
Kalb Michael Wayne SVP and CFO Feb 22, 2019 Sale $18.97 50,000 948,500 20,551 Feb 22, 2019, 09:31 PM
Kalb Michael Wayne SVP and CFO Feb 15, 2019 Sale $17.58 25,000 439,525 20,551 Feb 15, 2019, 08:16 PM
THERO JOHN F President and CEO Jan 31, 2019 Option Exercise $16.94 143,177 2,425,418 2,337,428 Feb 01, 2019, 08:35 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2019 Option Exercise $16.94 40,482 685,765 382,481 Feb 01, 2019, 08:35 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2019 Option Exercise $2.33 9,541 22,235 350,838 Feb 01, 2019, 08:35 PM
Ketchum Steven B Chief Scientific Officer Feb 01, 2019 Sale $17.06 27,989 477,498 354,492 Feb 01, 2019, 08:35 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2019 Sale $17.49 9,541 166,875 341,297 Feb 01, 2019, 08:35 PM
Kennedy Joseph T General Counsel Jan 31, 2019 Option Exercise $16.94 43,962 744,716 73,884 Feb 01, 2019, 08:34 PM
Kennedy Joseph T General Counsel Jan 31, 2019 Option Exercise $2.46 29,180 71,910 29,180 Feb 01, 2019, 08:34 PM
Kennedy Joseph T General Counsel Jan 31, 2019 Sale $17.49 42,624 745,468 31,260 Feb 01, 2019, 08:34 PM
Kalb Michael Wayne SVP and CFO Jan 31, 2019 Option Exercise $16.94 26,935 456,279 45,551 Feb 01, 2019, 08:33 PM
Kennedy Joseph T General Counsel Jan 23, 2019 Option Exercise $7.19 255,779 1,840,134 473,713 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 22, 2019 Option Exercise $4.59 175,300 804,656 393,234 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 24, 2019 Option Exercise $6.06 391,181 2,370,612 609,115 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 22, 2019 Sale $17.92 175,300 3,141,884 217,934 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 24, 2019 Sale $17.66 609,115 10,754,717 0 Jan 24, 2019, 08:20 PM
Kennedy Joseph T General Counsel Jan 23, 2019 Sale $17.95 255,779 4,591,310 217,934 Jan 24, 2019, 08:20 PM
Zakrzewski Joseph S Director Jan 10, 2019 Option Exercise $3.40 200,000 680,000 284,547 Jan 11, 2019, 08:18 PM
Zakrzewski Joseph S Director Jan 10, 2019 Sale $16.98 200,000 3,396,390 184,547 Jan 11, 2019, 08:18 PM
STACK DAVID M Director Jan 10, 2019 Option Exercise $2.94 26,932 79,172 26,932 Jan 11, 2019, 08:18 PM
STACK DAVID M Director Jan 10, 2019 Option Exercise $5.86 98,572 577,855 98,572 Jan 11, 2019, 08:18 PM
STACK DAVID M Director Jan 10, 2019 Sale $18.00 98,572 1,774,296 0 Jan 11, 2019, 08:18 PM
STACK DAVID M Director Jan 10, 2019 Sale $18.00 26,932 484,776 0 Jan 11, 2019, 08:18 PM
Kennedy Joseph T General Counsel Jan 11, 2019 Option Exercise $2.95 3,173 9,360 221,107 Jan 11, 2019, 08:17 PM
Kennedy Joseph T General Counsel Jan 11, 2019 Sale $18.92 3,173 60,033 217,934 Jan 11, 2019, 08:17 PM
Kalb Michael Wayne SVP and CFO Jan 09, 2019 Option Exercise $2.19 200,000 438,000 217,486 Jan 11, 2019, 08:16 PM
Kalb Michael Wayne SVP and CFO Jan 09, 2019 Sale $15.26 200,000 3,051,080 17,486 Jan 11, 2019, 08:16 PM
Ekman Lars Director Jan 10, 2019 Option Exercise $1.03 100,416 103,428 140,416 Jan 11, 2019, 08:16 PM
Ekman Lars Director Jan 10, 2019 Sale $17.28 140,416 2,426,489 119,216 Jan 11, 2019, 08:16 PM
Zakrzewski Joseph S Director Jan 02, 2019 Option Exercise $3.21 385,000 1,237,250 469,547 Jan 02, 2019, 07:54 PM
Zakrzewski Joseph S Director Dec 28, 2018 Sale $13.19 141,500 1,866,668 84,547 Jan 02, 2019, 07:54 PM
Zakrzewski Joseph S Director Jan 02, 2019 Sale $13.03 385,000 5,015,703 84,547 Jan 02, 2019, 07:54 PM
Kennedy Joseph T General Counsel Dec 31, 2018 Option Exercise $13.24 26,495 350,794 244,877 Jan 02, 2019, 07:53 PM
Kennedy Joseph T General Counsel Dec 31, 2018 Sale $13.49 26,943 363,547 217,934 Jan 02, 2019, 07:53 PM
Ketchum Steven B Chief Scientific Officer Dec 31, 2018 Option Exercise $2.41 17,041 40,985 358,338 Jan 02, 2019, 07:51 PM
Ketchum Steven B Chief Scientific Officer Dec 31, 2018 Sale $13.51 17,041 230,212 341,297 Jan 02, 2019, 07:51 PM
THERO JOHN F President and CEO Dec 31, 2018 Option Exercise $13.24 14,757 195,383 2,117,271 Jan 02, 2019, 07:45 PM
Ketchum Steven B Chief Scientific Officer Nov 30, 2018 Option Exercise $2.41 17,042 40,988 358,339 Nov 30, 2018, 06:34 PM
Ketchum Steven B Chief Scientific Officer Nov 30, 2018 Sale $17.79 17,042 303,174 341,297 Nov 30, 2018, 06:34 PM
Kennedy Joseph T General Counsel Nov 30, 2018 Option Exercise $2.25 23,306 52,510 241,240 Nov 30, 2018, 06:33 PM
Kennedy Joseph T General Counsel Nov 30, 2018 Sale $17.81 23,306 414,998 217,934 Nov 30, 2018, 06:33 PM
THERO JOHN F President and CEO Nov 12, 2018 Option Exercise $1.35 407,611 550,275 2,702,139 Nov 14, 2018, 06:02 PM
THERO JOHN F President and CEO Nov 12, 2018 Sale $19.07 607,611 11,587,896 2,565,717 Nov 14, 2018, 06:02 PM
Ketchum Steven B Chief Scientific Officer Oct 31, 2018 Option Exercise $2.41 17,042 40,988 358,339 Nov 02, 2018, 06:11 PM
Ketchum Steven B Chief Scientific Officer Oct 31, 2018 Sale $20.74 17,042 353,454 341,797 Nov 02, 2018, 06:11 PM
Kennedy Joseph T General Counsel Oct 31, 2018 Option Exercise $2.25 23,307 52,513 241,241 Nov 02, 2018, 06:10 PM
Kennedy Joseph T General Counsel Oct 31, 2018 Sale $20.74 23,307 483,362 218,534 Nov 02, 2018, 06:10 PM
THERO JOHN F President and CEO Sep 30, 2018 Option Exercise $16.27 14,757 240,096 2,294,528 Oct 02, 2018, 07:11 PM
Ketchum Steven B Chief Scientific Officer Sep 28, 2018 Option Exercise $8.77 200,000 1,754,000 541,297 Oct 02, 2018, 07:05 PM
Ketchum Steven B Chief Scientific Officer Oct 01, 2018 Option Exercise $7.86 116,604 916,893 457,901 Oct 02, 2018, 07:05 PM
Ketchum Steven B Chief Scientific Officer Sep 28, 2018 Sale $15.50 200,000 3,100,000 441,297 Oct 02, 2018, 07:05 PM
Ketchum Steven B Chief Scientific Officer Oct 01, 2018 Sale $17.20 116,604 2,005,589 341,297 Oct 02, 2018, 07:05 PM
Kennedy Joseph T General Counsel Sep 30, 2018 Option Exercise $16.27 26,495 431,074 244,877 Oct 02, 2018, 07:02 PM
Kennedy Joseph T General Counsel Oct 01, 2018 Option Exercise $2.25 23,306 52,510 268,183 Oct 02, 2018, 07:02 PM
Kennedy Joseph T General Counsel Oct 01, 2018 Sale $16.81 50,249 844,528 235,134 Oct 02, 2018, 07:02 PM
Zakrzewski Joseph S Director Sep 24, 2018 Option Exercise $3.40 500,000 1,700,000 726,047 Sep 26, 2018, 08:54 PM
Zakrzewski Joseph S Director Sep 24, 2018 Sale $10.60 500,000 5,299,334 318,796 Sep 26, 2018, 08:54 PM
Ketchum Steven B Chief Scientific Officer Sep 25, 2018 Option Exercise $8.77 200,000 1,754,000 541,297 Sep 26, 2018, 08:52 PM
Ketchum Steven B Chief Scientific Officer Sep 24, 2018 Option Exercise $3.82 620,065 2,366,711 1,020,538 Sep 26, 2018, 08:52 PM
Ketchum Steven B Chief Scientific Officer Sep 24, 2018 Sale $10.39 679,241 7,060,024 490,747 Sep 26, 2018, 08:52 PM
Ketchum Steven B Chief Scientific Officer Sep 25, 2018 Sale $13.50 200,000 2,700,000 441,297 Sep 26, 2018, 08:52 PM
Kennedy Joseph T General Counsel Sep 24, 2018 Option Exercise $2.22 1,079,706 2,393,014 1,297,640 Sep 26, 2018, 08:50 PM
Kennedy Joseph T General Counsel Sep 24, 2018 Sale $10.56 1,079,706 11,400,975 412,840 Sep 26, 2018, 08:50 PM
Kalb Michael Wayne SVP and CFO Sep 24, 2018 Option Exercise $2.19 150,000 328,500 164,996 Sep 26, 2018, 08:47 PM
Kalb Michael Wayne SVP and CFO Sep 24, 2018 Sale $10.42 150,000 1,562,751 85,196 Sep 26, 2018, 08:47 PM
THERO JOHN F President and CEO Sep 22, 2018 Option Exercise $2.99 497,876 1,488,649 2,271,785 Sep 25, 2018, 06:35 PM
THERO JOHN F President and CEO Jun 30, 2018 Option Exercise $3.09 14,757 45,599 1,504,411 Jul 03, 2018, 12:00 AM
Kennedy Joseph T General Counsel Jun 30, 2018 Option Exercise $3.09 26,495 81,870 45,376 Jul 03, 2018, 12:00 AM
Kennedy Joseph T General Counsel Jul 02, 2018 Sale $3.00 26,942 80,955 18,434 Jul 03, 2018, 12:00 AM
THERO JOHN F President and CEO Mar 31, 2018 Option Exercise $3.01 14,757 44,419 1,481,668 Apr 03, 2018, 08:12 PM
Kennedy Joseph T General Counsel Mar 31, 2018 Option Exercise $3.01 26,495 79,750 45,376 Apr 03, 2018, 08:12 PM
Kennedy Joseph T General Counsel Apr 03, 2018 Sale $2.89 19,042 55,052 18,434 Apr 03, 2018, 08:12 PM
Kennedy Joseph T General Counsel Apr 02, 2018 Sale $2.91 7,900 23,020 37,476 Apr 03, 2018, 08:12 PM
THERO JOHN F President and CEO Jan 31, 2018 Option Exercise $3.83 197,513 756,475 1,458,925 Feb 02, 2018, 08:28 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2018 Option Exercise $3.83 57,428 219,949 200,973 Feb 02, 2018, 08:26 PM
Kennedy Joseph T General Counsel Jan 31, 2018 Option Exercise $3.83 60,313 230,999 63,291 Feb 02, 2018, 08:25 PM
Kennedy Joseph T General Counsel Jan 31, 2018 Sale $3.73 44,857 167,388 18,434 Feb 02, 2018, 08:25 PM
Kalb Michael Wayne SVP and CFO Jan 31, 2018 Option Exercise $3.83 14,004 53,635 14,996 Feb 02, 2018, 08:24 PM
Ketchum Steven B Chief Scientific Officer Jan 23, 2018 Option Exercise $2.04 135,205 275,818 277,002 Jan 23, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 23, 2018 Sale $4.41 135,205 596,430 141,797 Jan 23, 2018, 06:00 PM
Kennedy Joseph T General Counsel Jan 12, 2018 Sale $4.29 9,587 41,128 41,519 Jan 17, 2018, 05:58 PM
Kennedy Joseph T General Counsel Jan 17, 2018 Sale $4.03 31,519 127,022 0 Jan 17, 2018, 05:58 PM
Kennedy Joseph T General Counsel Jan 16, 2018 Sale $4.13 10,000 41,300 31,519 Jan 17, 2018, 05:58 PM
Ketchum Steven B Chief Scientific Officer Jan 11, 2018 Option Exercise $2.04 2,612 5,328 144,409 Jan 16, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 11, 2018 Sale $4.40 2,612 11,493 141,797 Jan 16, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 05, 2018 Option Exercise $2.04 64,683 131,953 206,480 Jan 09, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 05, 2018 Sale $4.40 64,683 284,631 141,797 Jan 09, 2018, 06:00 PM
Ketchum Steven B Chief Scientific Officer Jan 02, 2018 Option Exercise $1.20 128,257 153,583 270,054 Jan 04, 2018, 07:40 PM
Ketchum Steven B Chief Scientific Officer Jan 02, 2018 Sale $4.25 128,257 545,092 141,797 Jan 04, 2018, 07:40 PM
THERO JOHN F President and CEO Dec 31, 2017 Option Exercise $4.01 15,732 63,085 1,156,771 Jan 02, 2018, 04:32 PM
Kennedy Joseph T General Counsel Dec 31, 2017 Option Exercise $4.01 27,885 111,819 51,106 Jan 02, 2018, 04:32 PM
THERO JOHN F President and CEO Nov 30, 2017 Buy $3.24 10,000 32,446 1,135,003 Dec 04, 2017, 09:02 AM
Ketchum Steven B Chief Scientific Officer Oct 05, 2017 Sale $3.48 63,479 221,199 141,797 Oct 06, 2017, 07:22 PM
THERO JOHN F President and CEO Sep 30, 2017 Option Exercise $3.50 15,732 55,062 1,125,003 Oct 03, 2017, 04:24 PM
Kennedy Joseph T General Counsel Sep 30, 2017 Option Exercise $3.50 27,885 97,598 25,553 Oct 03, 2017, 04:24 PM
THERO JOHN F President and CEO Jun 30, 2017 Option Exercise $4.03 15,732 63,400 1,103,235 Jul 03, 2017, 07:21 PM
Kennedy Joseph T General Counsel Jun 30, 2017 Option Exercise $4.03 27,885 112,377 156,143 Jul 03, 2017, 07:20 PM
Kennedy Joseph T General Counsel Jun 29, 2017 Sale $3.98 151,768 603,824 130,591 Jul 03, 2017, 07:20 PM
Kennedy Joseph T General Counsel Jul 03, 2017 Sale $4.09 51,104 209,158 0 Jul 03, 2017, 07:20 PM
Kennedy Joseph T General Counsel Jun 30, 2017 Sale $3.98 105,039 417,950 51,104 Jul 03, 2017, 07:20 PM
Kennedy Joseph T General Counsel Mar 31, 2017 Option Exercise $3.20 26,981 86,339 282,359 Apr 03, 2017, 05:01 PM
THERO JOHN F President and CEO Mar 31, 2017 Option Exercise $3.20 15,732 50,342 1,081,467 Apr 03, 2017, 05:00 PM
THERO JOHN F President and CEO Jan 31, 2017 Option Exercise $2.97 231,718 688,202 1,059,699 Feb 02, 2017, 05:07 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2017 Option Exercise $2.97 70,236 208,601 205,276 Feb 02, 2017, 05:06 PM
Kennedy Joseph T General Counsel Jan 31, 2017 Option Exercise $2.97 75,875 225,349 255,903 Feb 02, 2017, 05:04 PM
Kennedy Joseph T General Counsel Dec 31, 2016 Option Exercise $3.08 27,885 85,886 187,673 Jan 03, 2017, 04:31 PM
THERO JOHN F President and CEO Dec 31, 2016 Option Exercise $3.08 20,194 62,198 741,917 Jan 03, 2017, 04:30 PM
Kennedy Joseph T General Counsel Nov 09, 2016 Sale $3.04 122,358 372,042 162,120 Nov 10, 2016, 05:00 PM
Kennedy Joseph T General Counsel Sep 30, 2016 Option Exercise $3.19 27,885 88,953 284,478 Sep 30, 2016, 09:26 PM
THERO JOHN F President and CEO Sep 30, 2016 Option Exercise $3.19 20,194 64,419 724,611 Sep 30, 2016, 09:25 PM
THERO JOHN F President and CEO Jun 30, 2016 Option Exercise $2.16 14,719 31,793 707,305 Jul 05, 2016, 07:09 PM
Kennedy Joseph T General Counsel Jun 30, 2016 Option Exercise $2.16 27,885 60,232 258,925 Jul 05, 2016, 07:08 PM
Kennedy Joseph T General Counsel Mar 31, 2016 Option Exercise $1.53 20,082 30,725 233,373 Apr 01, 2016, 06:00 PM
THERO JOHN F President and CEO Mar 31, 2016 Option Exercise $1.53 14,719 22,520 684,524 Apr 01, 2016, 05:58 PM
THERO JOHN F President and CEO Feb 01, 2016 Buy $1.37 25,000 34,250 661,743 Feb 03, 2016, 08:11 AM
THERO JOHN F President and CEO Jan 31, 2016 Option Exercise $1.36 172,157 234,134 636,743 Feb 02, 2016, 04:18 PM
Ketchum Steven B Chief Scientific Officer Jan 31, 2016 Option Exercise $1.36 42,531 57,842 131,407 Feb 02, 2016, 04:17 PM
Kennedy Joseph T General Counsel Jan 31, 2016 Option Exercise $1.36 47,581 64,710 200,018 Feb 02, 2016, 04:15 PM
Farrell Michael James VP, Finance Jan 31, 2016 Option Exercise $1.36 11,597 15,772 30,190 Feb 02, 2016, 04:14 PM
Kennedy Joseph T General Counsel Dec 31, 2015 Option Exercise $1.89 20,082 37,955 130,161 Jan 04, 2016, 05:14 PM
Kennedy Joseph T General Counsel Oct 05, 2015 Option Exercise $2.05 2,349 4,815 96,805 Oct 06, 2015, 04:31 PM
Kennedy Joseph T General Counsel Sep 30, 2015 Option Exercise $1.93 17,734 34,227 92,904 Oct 02, 2015, 04:31 PM
THERO JOHN F President and CEO Aug 11, 2015 Buy $2.35 20,000 47,000 304,400 Aug 11, 2015, 04:30 PM
Farrell Michael James Controller Nov 11, 2014 Buy $0.84 5,500 4,606 6,037 Nov 12, 2014, 07:59 PM
THERO JOHN F President, Chief Exec. Officer Nov 12, 2014 Buy $0.88 20,000 17,600 114,900 Nov 12, 2014, 07:59 PM
THERO JOHN F President, Chief Exec. Officer Nov 11, 2014 Buy $0.80 30,000 24,000 94,900 Nov 12, 2014, 07:59 PM
Ekman Lars Director Nov 20, 2013 Buy $1.80 40,000 72,000 40,000 Nov 20, 2013, 06:11 PM
THERO JOHN F President Nov 20, 2013 Buy $1.90 5,000 9,500 64,900 Nov 20, 2013, 04:18 PM
Zakrzewski Joseph S Chief Executive Officer Nov 18, 2013 Buy $1.54 50,777 78,197 226,047 Nov 18, 2013, 04:15 PM
VAN HEEK G JAN Director Jul 10, 2013 Option Exercise $5.59 1,755 9,810 25,203 Jul 11, 2013, 06:59 AM
Zakrzewski Joseph S Chief Executive Officer Jun 25, 2013 Option Exercise $1.35 10,000 13,500 141,937 Jun 25, 2013, 04:05 PM
Zakrzewski Joseph S Chief Executive Officer Jun 21, 2013 Option Exercise $1.35 10,000 13,500 131,937 Jun 21, 2013, 04:05 PM
THERO JOHN F President May 29, 2013 Option Exercise $1.35 11,000 14,850 50,450 May 29, 2013, 04:30 PM
Zakrzewski Joseph S Chief Executive Officer Apr 25, 2013 Option Exercise $1.35 10,000 13,500 121,937 Apr 25, 2013, 04:23 PM
VAN HEEK G JAN Director Apr 10, 2013 Option Exercise $7.38 1,329 9,808 23,448 Apr 15, 2013, 08:44 AM
THERO JOHN F President Jan 30, 2013 Option Exercise $1.35 10,000 13,500 39,450 Jan 30, 2013, 05:58 PM
VAN HEEK G JAN Director Jan 10, 2013 Option Exercise $8.37 948 7,935 22,119 Jan 14, 2013, 07:08 AM
VAN HEEK G JAN Director Oct 10, 2012 Option Exercise $11.20 708 7,930 21,171 Oct 12, 2012, 08:32 AM
Zakrzewski Joseph S Chief Executive Officer Oct 01, 2012 Option Exercise $1.35 150,000 202,500 261,937 Oct 03, 2012, 09:50 PM
Zakrzewski Joseph S Chief Executive Officer Oct 01, 2012 Sale $12.56 150,000 1,884,315 111,937 Oct 03, 2012, 09:50 PM
THERO JOHN F President Sep 24, 2012 Option Exercise $1.35 10,000 13,500 29,450 Sep 24, 2012, 04:35 PM
THERO JOHN F President Sep 11, 2012 Option Exercise $1.35 10,000 13,500 19,450 Sep 11, 2012, 06:13 PM
HEALY JAMES Director Aug 31, 2012 Option Exercise $1.03 30,000 30,900 90,000 Sep 05, 2012, 06:33 PM
GORDON CARL L Director Sep 04, 2012 Sale $14.43 233,700 3,372,992 594,300 Sep 05, 2012, 05:38 PM
ORBIMED ADVISORS LLC Director Sep 04, 2012 Sale $14.43 233,700 3,372,992 594,300 Sep 05, 2012, 05:33 PM
HEALY JAMES Director Aug 14, 2012 Option Exercise $1.50 808,200 1,212,300 6,321,588 Aug 15, 2012, 07:28 PM
GORDON CARL L Director Jul 27, 2012 Sale $14.61 366,300 5,350,691 825,756 Jul 30, 2012, 07:32 PM
ORBIMED ADVISORS LLC Director Jul 27, 2012 Sale $14.61 3,456 50,483 7,944 Jul 30, 2012, 07:26 PM
ORBIMED ADVISORS LLC Director Jul 27, 2012 Sale $14.61 362,844 5,300,207 825,756 Jul 30, 2012, 07:26 PM
Zakrzewski Joseph S Chief Executive Officer Jul 27, 2012 Option Exercise $1.35 150,000 202,500 261,937 Jul 30, 2012, 06:51 PM
Zakrzewski Joseph S Chief Executive Officer Jul 27, 2012 Sale $14.31 150,000 2,147,192 189,991 Jul 30, 2012, 06:51 PM
THERO JOHN F President Jul 27, 2012 Option Exercise $2.37 300,926 713,750 160,376 Jul 30, 2012, 06:50 PM
THERO JOHN F President Jul 27, 2012 Sale $14.34 300,926 4,315,862 9,450 Jul 30, 2012, 06:50 PM
Kennedy Joseph T Senior VP and General Counsel Jul 27, 2012 Sale $13.85 6,950 96,290 6,409 Jul 30, 2012, 06:49 PM
Huff Paul Chief Commercial Officer Jul 27, 2012 Sale $13.85 6,950 96,290 6,409 Jul 30, 2012, 06:48 PM
SEDLACK STUART D Senior Vice President Jul 27, 2012 Sale $13.85 6,950 96,290 6,409 Jul 30, 2012, 06:46 PM
VAN HEEK G JAN Director Jul 10, 2012 Option Exercise $14.40 551 7,934 20,463 Jul 12, 2012, 06:36 PM
Huff Paul Chief Commercial Officer Jun 26, 2012 Option Exercise $8.79 1,100 9,669 1,100 Jun 27, 2012, 05:30 PM
Huff Paul Chief Commercial Officer Jun 27, 2012 Option Exercise $8.79 48,900 429,831 48,900 Jun 27, 2012, 05:30 PM
Huff Paul Chief Commercial Officer Jun 27, 2012 Sale $15.01 48,900 734,204 0 Jun 27, 2012, 05:30 PM
Huff Paul Chief Commercial Officer Jun 26, 2012 Sale $13.52 1,100 14,870 0 Jun 27, 2012, 05:30 PM
GORDON CARL L Director Jun 19, 2012 Sale $12.94 617,100 7,986,701 1,188,600 Jun 19, 2012, 07:37 PM
ORBIMED ADVISORS LLC Director Jun 19, 2012 Sale $12.91 5,900 76,185 11,400 Jun 19, 2012, 07:31 PM
ORBIMED ADVISORS LLC Director Jun 19, 2012 Sale $12.91 611,200 7,892,242 1,188,600 Jun 19, 2012, 07:31 PM
Huff Paul Chief Commercial Officer Jun 15, 2012 Option Exercise $8.79 100 879 100 Jun 19, 2012, 07:03 PM
Huff Paul Chief Commercial Officer Jun 18, 2012 Option Exercise $8.79 162,925 1,432,111 162,925 Jun 19, 2012, 07:03 PM
Huff Paul Chief Commercial Officer Jun 15, 2012 Sale $12.00 100 1,200 0 Jun 19, 2012, 07:03 PM
Huff Paul Chief Commercial Officer Jun 18, 2012 Sale $12.00 162,925 1,955,524 0 Jun 19, 2012, 07:03 PM
Huff Paul Chief Commercial Officer Jun 07, 2012 Option Exercise $6.64 16,725 111,008 16,725 Jun 08, 2012, 05:08 PM
Huff Paul Chief Commercial Officer Jun 07, 2012 Sale $12.06 16,725 201,635 0 Jun 08, 2012, 05:08 PM
Zakrzewski Joseph S Chief Executive Officer May 29, 2012 Option Exercise $1.35 150,000 202,500 228,604 May 31, 2012, 07:46 PM
Zakrzewski Joseph S Chief Executive Officer May 29, 2012 Sale $11.97 150,000 1,795,215 78,604 May 31, 2012, 07:46 PM
Abingworth LLP 10% Owner Apr 17, 2012 Sale $9.61 1,712,000 16,454,204 3,895,509 Apr 26, 2012, 05:04 PM
Abingworth LLP 10% Owner Apr 19, 2012 Sale $9.66 682,000 6,586,347 1,599,168 Apr 26, 2012, 05:04 PM
Abingworth LLP 10% Owner Apr 18, 2012 Sale $9.60 1,614,341 15,505,584 2,281,168 Apr 26, 2012, 05:04 PM
Abingworth LLP 10% Owner Apr 19, 2012 Sale $9.66 682,000 6,586,347 1,599,168 Apr 19, 2012, 05:58 PM
Abingworth LLP 10% Owner Apr 18, 2012 Sale $9.60 1,614,341 15,505,584 2,281,168 Apr 19, 2012, 05:58 PM
Abingworth LLP 10% Owner Apr 17, 2012 Sale $9.61 1,712,000 16,454,204 3,895,509 Apr 19, 2012, 05:58 PM
VAN HEEK G JAN Director Apr 10, 2012 Option Exercise $9.35 848 7,929 19,912 Apr 12, 2012, 07:46 PM
THERO JOHN F President Apr 09, 2012 Option Exercise $1.35 150,926 203,750 150,926 Apr 11, 2012, 05:57 PM
THERO JOHN F President Apr 09, 2012 Sale $9.96 150,926 1,503,072 0 Apr 11, 2012, 05:57 PM
Abingworth LLP 10% Owner Apr 03, 2012 Sale $11.00 2,300,000 25,300,000 5,607,509 Apr 05, 2012, 05:15 PM
HEALY JAMES Director Apr 02, 2012 Sale $10.99 264,350 2,905,286 7,249,038 Apr 04, 2012, 05:00 PM
HEALY JAMES Director Apr 03, 2012 Sale $10.98 1,735,650 19,059,665 6,513,388 Apr 04, 2012, 05:00 PM
HEALY JAMES Director Mar 29, 2012 Sale $10.98 993,698 10,910,804 7,513,388 Mar 30, 2012, 04:15 PM
HEALY JAMES Director Mar 28, 2012 Sale $11.73 6,302 73,922 8,507,086 Mar 30, 2012, 04:15 PM
Zakrzewski Joseph S Chief Executive Officer Mar 23, 2012 Option Exercise $1.35 160,000 216,000 238,604 Mar 27, 2012, 07:01 PM
Zakrzewski Joseph S Chief Executive Officer Mar 23, 2012 Sale $11.59 160,000 1,854,560 78,604 Mar 27, 2012, 07:01 PM
HEALY JAMES Director Jan 27, 2012 Option Exercise $1.03 60,000 61,800 60,000 Jan 31, 2012, 05:51 PM
VAN HEEK G JAN Director Jan 10, 2012 Option Exercise $7.06 894 6,312 19,064 Jan 12, 2012, 06:07 PM
Zakrzewski Joseph S Chief Executive Officer Nov 07, 2011 Option Exercise $1.35 5,000 6,750 78,604 Nov 07, 2011, 04:50 PM
VAN HEEK G JAN Director Oct 11, 2011 Option Exercise $9.47 666 6,307 18,170 Oct 18, 2011, 06:34 PM
Anderson Joseph Director Oct 11, 2011 Option Exercise $9.47 832 7,879 11,683 Oct 18, 2011, 06:32 PM
Zakrzewski Joseph S Chief Executive Officer Aug 22, 2011 Option Exercise $1.35 5,000 6,750 73,604 Aug 22, 2011, 05:01 PM
Zakrzewski Joseph S Chief Executive Officer Jul 15, 2011 Option Exercise $1.35 5,000 6,750 68,604 Jul 15, 2011, 07:07 PM
Zakrzewski Joseph S Chief Executive Officer Jul 15, 2011 Option Exercise $1.35 5,000 6,750 68,604 Jul 15, 2011, 05:57 PM
VAN HEEK G JAN Director Jul 11, 2011 Option Exercise $14.18 445 6,310 17,504 Jul 13, 2011, 05:27 PM
Anderson Joseph Director Jul 11, 2011 Option Exercise $14.18 468 6,636 10,851 Jul 13, 2011, 05:25 PM
Anderson Joseph Director Jul 12, 2010 Option Exercise $2.28 2,801 6,386 6,743 May 16, 2011, 09:46 PM
Anderson Joseph Director Apr 12, 2010 Option Exercise $1.62 3,942 6,386 3,942 May 16, 2011, 09:46 PM
Anderson Joseph Director Apr 11, 2011 Option Exercise $8.50 751 6,384 10,383 May 16, 2011, 09:46 PM
Anderson Joseph Director Jan 10, 2011 Option Exercise $8.81 724 6,378 9,632 May 16, 2011, 09:46 PM
Anderson Joseph Director Oct 11, 2010 Option Exercise $2.95 2,165 6,387 8,908 May 16, 2011, 09:46 PM
VAN HEEK G JAN Director Apr 11, 2011 Option Exercise $8.50 742 6,307 17,059 May 16, 2011, 09:25 PM
ORBIMED ADVISORS LLC Director May 02, 2011 Sale $16.30 300 4,890 17,300 May 03, 2011, 07:26 PM
ORBIMED ADVISORS LLC Director May 02, 2011 Sale $16.30 32,600 531,380 1,799,800 May 03, 2011, 07:26 PM
ORBIMED ADVISORS LLC Director Apr 29, 2011 Sale $16.01 1,000 16,010 17,600 May 03, 2011, 07:26 PM
ORBIMED ADVISORS LLC Director Apr 29, 2011 Sale $16.01 99,000 1,584,990 1,832,400 May 03, 2011, 07:26 PM
GORDON CARL L Director Apr 29, 2011 Sale $16.01 100,000 1,601,000 1,832,400 May 03, 2011, 07:20 PM
GORDON CARL L Director May 02, 2011 Sale $16.30 32,900 536,270 1,799,800 May 03, 2011, 07:20 PM
VAN HEEK G JAN Director Apr 25, 2011 Option Exercise $1.03 30,000 30,900 46,317 Apr 27, 2011, 06:44 PM
VAN HEEK G JAN Director Apr 25, 2011 Sale $16.58 30,000 497,379 16,317 Apr 27, 2011, 06:44 PM
VAN HEEK G JAN Director Apr 18, 2011 Sale $1.03 3,000 3,090 16,317 Apr 27, 2011, 06:37 PM
ORBIMED ADVISORS LLC Director Apr 20, 2011 Sale $15.79 7,600 120,004 25,700 Apr 26, 2011, 08:21 PM
ORBIMED ADVISORS LLC Director Apr 20, 2011 Sale $15.79 792,400 12,511,996 2,674,300 Apr 26, 2011, 08:21 PM
GORDON CARL L Director Apr 20, 2011 Sale $15.79 7,600 120,004 25,700 Apr 26, 2011, 08:16 PM
GORDON CARL L Director Apr 20, 2011 Sale $15.79 792,400 12,511,996 2,674,300 Apr 26, 2011, 08:16 PM
GORDON CARL L Director Apr 21, 2011 Sale $16.67 750,000 12,500,000 2,426,667 Apr 25, 2011, 09:51 PM
ORBIMED ADVISORS LLC Director Apr 21, 2011 Sale $16.67 7,100 118,333 23,333 Apr 25, 2011, 09:46 PM
ORBIMED ADVISORS LLC Director Apr 21, 2011 Sale $16.67 742,900 12,381,667 2,426,667 Apr 25, 2011, 09:46 PM
GORDON CARL L Director Apr 18, 2011 Sale $15.18 3,000,000 45,549,897 4,682,029 Apr 20, 2011, 09:43 PM
GORDON CARL L Director Apr 20, 2011 Sale $15.79 800,000 12,632,000 2,674,300 Apr 20, 2011, 09:43 PM
ORBIMED ADVISORS LLC Director Apr 20, 2011 Sale $15.79 800,000 12,632,000 2,674,300 Apr 20, 2011, 09:39 PM
ORBIMED ADVISORS LLC Director Apr 18, 2011 Sale $15.18 28,200 428,168 44,832 Apr 20, 2011, 09:39 PM
ORBIMED ADVISORS LLC Director Apr 18, 2011 Sale $15.18 2,971,800 45,121,729 4,682,029 Apr 20, 2011, 09:39 PM
Zakrzewski Joseph S Chief Executive Officer Apr 18, 2011 Option Exercise $2.72 300,000 815,000 363,604 Apr 20, 2011, 07:49 PM
Zakrzewski Joseph S Chief Executive Officer Apr 18, 2011 Sale $15.76 300,000 4,728,210 63,604 Apr 20, 2011, 07:49 PM
VAN HEEK G JAN Director Apr 18, 2011 Option Exercise $1.03 3,000 3,090 22,317 Apr 20, 2011, 07:41 PM
VAN HEEK G JAN Director Apr 18, 2011 Sale $16.51 3,000 49,530 19,317 Apr 20, 2011, 07:41 PM
Soni Paresh SVP and Head of Development Apr 19, 2011 Option Exercise $1.35 80,000 108,000 80,000 Apr 20, 2011, 07:39 PM
Soni Paresh SVP and Head of Development Apr 19, 2011 Sale $15.11 80,000 1,208,624 0 Apr 20, 2011, 07:39 PM
Ahlholm Frederick W Vice President Finance Apr 20, 2011 Option Exercise $1.70 31,250 53,125 31,250 Apr 20, 2011, 07:38 PM
Ahlholm Frederick W Vice President Finance Apr 20, 2011 Sale $15.88 31,250 496,344 0 Apr 20, 2011, 07:38 PM
Abingworth LLP 10% Owner Apr 18, 2011 Sale $14.87 4,179,174 62,143,480 7,895,826 Apr 20, 2011, 04:33 PM
Ahlholm Frederick W Vice President Finance Apr 04, 2011 Option Exercise $1.70 31,250 53,125 31,250 Apr 06, 2011, 05:42 PM
Ahlholm Frederick W Vice President Finance Apr 04, 2011 Sale $7.48 31,250 233,688 0 Apr 06, 2011, 05:42 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 29, 2011 Sale $7.25 424,900 3,080,610 8,513,388 Mar 31, 2011, 03:16 PM
GORDON CARL L Director Mar 28, 2011 Sale $7.35 93,100 684,285 6,438,500 Mar 28, 2011, 09:45 PM
GORDON CARL L Director Mar 25, 2011 Sale $7.47 56,900 425,043 6,530,700 Mar 28, 2011, 09:45 PM
GORDON CARL L Director Mar 24, 2011 Sale $7.50 23,000 172,500 6,587,100 Mar 28, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 24, 2011 Sale $7.50 22,800 171,000 6,587,100 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 28, 2011 Sale $7.35 92,200 677,670 6,438,500 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 25, 2011 Sale $7.47 500 3,735 62,400 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 25, 2011 Sale $7.47 56,400 421,308 6,530,700 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 24, 2011 Sale $7.50 200 1,500 62,900 Mar 28, 2011, 09:41 PM
ORBIMED ADVISORS LLC Director Mar 28, 2011 Sale $7.35 900 6,615 61,500 Mar 28, 2011, 09:41 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 25, 2011 Sale $7.50 75,100 563,333 8,938,288 Mar 28, 2011, 08:37 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 24, 2011 Sale $7.56 500,000 3,778,000 9,013,388 Mar 28, 2011, 08:37 PM
GORDON CARL L Director Mar 21, 2011 Sale $7.05 77,000 542,850 6,609,900 Mar 23, 2011, 06:31 PM
ORBIMED ADVISORS LLC Director Mar 21, 2011 Sale $7.05 700 4,935 63,100 Mar 23, 2011, 06:27 PM
ORBIMED ADVISORS LLC Director Mar 21, 2011 Sale $7.05 76,300 537,915 6,609,900 Mar 23, 2011, 06:27 PM
GORDON CARL L Director Mar 11, 2011 Sale $7.43 100,000 743,000 6,810,000 Mar 15, 2011, 09:34 PM
GORDON CARL L Director Mar 15, 2011 Sale $7.24 50,000 362,000 6,686,200 Mar 15, 2011, 09:34 PM
GORDON CARL L Director Mar 14, 2011 Sale $7.33 75,000 549,750 6,735,700 Mar 15, 2011, 09:34 PM
ORBIMED ADVISORS LLC Director Mar 14, 2011 Sale $7.33 74,300 544,619 6,735,700 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 15, 2011 Sale $7.24 500 3,620 63,800 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 11, 2011 Sale $7.43 900 6,687 65,000 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 15, 2011 Sale $7.24 49,500 358,380 6,686,200 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 11, 2011 Sale $7.43 99,100 736,313 6,810,000 Mar 15, 2011, 09:29 PM
ORBIMED ADVISORS LLC Director Mar 14, 2011 Sale $7.33 700 5,131 64,300 Mar 15, 2011, 09:29 PM
Abingworth LLP 10% Owner Mar 11, 2011 Sale $7.50 2,750,000 20,636,001 12,075,000 Mar 15, 2011, 02:16 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 11, 2011 Sale $7.50 2,000,000 15,000,000 9,513,388 Mar 14, 2011, 06:35 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 10, 2011 Sale $7.26 606,300 4,400,283 11,513,388 Mar 11, 2011, 09:27 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 09, 2011 Sale $7.25 30,700 222,575 12,119,688 Mar 11, 2011, 09:27 PM
Abingworth LLP 10% Owner Mar 08, 2011 Sale $7.50 550,000 4,125,990 14,825,000 Mar 10, 2011, 04:22 PM
Zakrzewski Joseph S Chief Executive Officer Mar 09, 2011 Option Exercise $1.35 10,000 13,500 63,604 Mar 09, 2011, 06:22 PM
Abingworth LLP 10% Owner Mar 04, 2011 Sale $7.60 100,000 760,000 15,375,000 Mar 08, 2011, 05:15 PM
GORDON CARL L Director Mar 07, 2011 Sale $7.68 25,000 192,000 6,909,100 Mar 07, 2011, 09:51 PM
GORDON CARL L Director Mar 04, 2011 Sale $7.62 43,000 327,660 6,933,900 Mar 07, 2011, 09:51 PM
GORDON CARL L Director Mar 03, 2011 Sale $7.76 7,000 54,320 6,976,500 Mar 07, 2011, 09:51 PM
ORBIMED ADVISORS LLC Director Mar 03, 2011 Sale $7.76 100 776 66,500 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 07, 2011 Sale $7.68 200 1,536 65,900 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 03, 2011 Sale $7.76 6,900 53,544 6,976,500 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 07, 2011 Sale $7.68 24,800 190,464 6,909,100 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 04, 2011 Sale $7.62 400 3,048 66,100 Mar 07, 2011, 09:45 PM
ORBIMED ADVISORS LLC Director Mar 04, 2011 Sale $7.62 42,600 324,612 6,933,900 Mar 07, 2011, 09:45 PM
Abingworth LLP 10% Owner Mar 02, 2011 Sale $7.70 1,200,000 9,239,040 15,475,000 Mar 04, 2011, 01:31 PM
ORBIMED ADVISORS LLC Director Feb 28, 2011 Sale $7.73 99,100 766,043 7,127,000 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Mar 02, 2011 Sale $7.72 94,100 726,452 6,983,400 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Mar 01, 2011 Sale $7.56 500 3,780 67,500 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Mar 01, 2011 Sale $7.56 49,500 374,220 7,077,500 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Feb 28, 2011 Sale $7.73 900 6,957 68,000 Mar 02, 2011, 08:40 PM
ORBIMED ADVISORS LLC Director Mar 02, 2011 Sale $7.72 900 6,948 66,600 Mar 02, 2011, 08:40 PM
GORDON CARL L Director Mar 02, 2011 Sale $7.72 95,000 733,400 6,983,400 Mar 02, 2011, 08:33 PM
GORDON CARL L Director Mar 01, 2011 Sale $7.56 50,000 378,000 7,077,500 Mar 02, 2011, 08:33 PM
GORDON CARL L Director Feb 28, 2011 Sale $7.73 100,000 773,000 7,127,000 Mar 02, 2011, 08:33 PM
Abingworth LLP 10% Owner Mar 01, 2011 Sale $7.61 50,000 380,485 16,675,000 Mar 02, 2011, 01:57 PM
Abingworth LLP 10% Owner Feb 28, 2011 Sale $7.92 275,000 2,178,137 16,725,000 Mar 02, 2011, 01:57 PM
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Feb 25, 2011 Sale $8.13 363,000 2,952,787 12,150,388 Mar 01, 2011, 05:24 PM
Zakrzewski Joseph S Chief Executive Officer Feb 25, 2011 Option Exercise $1.35 60,000 81,000 103,604 Feb 28, 2011, 07:08 PM
Zakrzewski Joseph S Chief Executive Officer Feb 25, 2011 Sale $8.16 60,000 489,755 53,604 Feb 28, 2011, 07:08 PM
Zakrzewski Joseph S Chief Executive Officer Feb 22, 2011 Option Exercise $1.35 100,000 135,000 153,604 Feb 24, 2011, 06:05 PM
Zakrzewski Joseph S Chief Executive Officer Feb 22, 2011 Sale $8.54 100,000 854,060 53,604 Feb 24, 2011, 06:05 PM
Soni Paresh SVP and Head of Development Feb 22, 2011 Option Exercise $1.35 120,000 162,000 120,000 Feb 24, 2011, 06:01 PM
Soni Paresh SVP and Head of Development Feb 22, 2011 Sale $8.49 120,000 1,018,764 0 Feb 24, 2011, 06:01 PM

Desktop Version

Owner Relationship Date Transaction Value($)
THERO JOHN F President and CEO Aug 21, 2019 Option Exercise 62,498
THERO JOHN F President and CEO Aug 21, 2019 Option Exercise 300,010
STACK DAVID M Director Jul 11, 2019 Option Exercise 121,035
STACK DAVID M Director Jul 11, 2019 Sale 1,158,354
Zakrzewski Joseph S Director Jul 05, 2019 Option Exercise 900,000
Zakrzewski Joseph S Director Jul 05, 2019 Sale 2,381,580
Kennedy Joseph T General Counsel Jul 01, 2019 Option Exercise 69,962
Kennedy Joseph T General Counsel Jul 01, 2019 Sale 1,057,906
Kalb Michael Wayne SVP and CFO Jul 01, 2019 Option Exercise 109,500
Kalb Michael Wayne SVP and CFO Jul 01, 2019 Sale 983,270
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 02, 2019 Option Exercise 173,910
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 03, 2019 Option Exercise 81,900
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 03, 2019 Sale 662,238
Berg Aaron CHIEF COMMERCIAL OFFICER Jul 02, 2019 Sale 1,442,141
Kennedy Joseph T General Counsel Jun 30, 2019 Option Exercise 513,738
THERO JOHN F President and CEO Jun 30, 2019 Option Exercise 286,138
Berg Aaron CHIEF COMMERCIAL OFFICER Jun 24, 2019 Option Exercise 250,000
Berg Aaron CHIEF COMMERCIAL OFFICER Jun 24, 2019 Sale 2,104,521
Zakrzewski Joseph S Director Jun 18, 2019 Option Exercise 340,000
Zakrzewski Joseph S Director Jun 18, 2019 Sale 1,902,090
Kennedy Joseph T General Counsel May 31, 2019 Option Exercise 69,925
Kennedy Joseph T General Counsel May 31, 2019 Sale 488,058
STACK DAVID M Director May 29, 2019 Option Exercise 108,495
STACK DAVID M Director May 29, 2019 Sale 623,534
STACK DAVID M Director May 17, 2019 Option Exercise 42,289
STACK DAVID M Director May 17, 2019 Sale 237,139
Ketchum Steven B Chief Scientific Officer Apr 30, 2019 Option Exercise 22,235
Ketchum Steven B Chief Scientific Officer Apr 30, 2019 Sale 178,107
Kennedy Joseph T General Counsel Apr 30, 2019 Option Exercise 69,927
Kennedy Joseph T General Counsel Apr 30, 2019 Sale 508,839
Berg Aaron CHIEF COMMERCIAL OFFICER May 01, 2019 Option Exercise 239,454
THERO JOHN F President and CEO Mar 31, 2019 Option Exercise 306,355
Ketchum Steven B Chief Scientific Officer Apr 01, 2019 Option Exercise 22,236
Ketchum Steven B Chief Scientific Officer Apr 01, 2019 Sale 191,392
Kennedy Joseph T General Counsel Mar 31, 2019 Option Exercise 550,036
Kennedy Joseph T General Counsel Apr 01, 2019 Option Exercise 69,926
Kennedy Joseph T General Counsel Apr 01, 2019 Sale 1,086,122
THERO JOHN F President and CEO Mar 04, 2019 Sale 5,327,234
Ekman Lars Director Mar 04, 2019 Option Exercise 276,743
Ekman Lars Director Mar 04, 2019 Sale 2,884,905
Ketchum Steven B Chief Scientific Officer Mar 01, 2019 Option Exercise 115,000
Ketchum Steven B Chief Scientific Officer Feb 28, 2019 Option Exercise 22,239
Ketchum Steven B Chief Scientific Officer Feb 28, 2019 Sale 197,249
Ketchum Steven B Chief Scientific Officer Mar 01, 2019 Sale 1,016,275
Kalb Michael Wayne SVP and CFO Mar 01, 2019 Option Exercise 283,350
Kalb Michael Wayne SVP and CFO Mar 01, 2019 Sale 2,209,098
Kennedy Joseph T General Counsel Feb 28, 2019 Option Exercise 69,928
Kennedy Joseph T General Counsel Feb 28, 2019 Sale 564,172
Zakrzewski Joseph S Director Feb 22, 2019 Option Exercise 1,572,312
Zakrzewski Joseph S Director Feb 22, 2019 Sale 3,594,437
VAN HEEK G JAN Director Feb 22, 2019 Option Exercise 857,170
VAN HEEK G JAN Director Feb 22, 2019 Sale 4,071,423
Peterson Kristine Director Feb 22, 2019 Option Exercise 947,730
Peterson Kristine Director Feb 22, 2019 Sale 3,274,038
Kalb Michael Wayne SVP and CFO Feb 22, 2019 Option Exercise 147,500
Kalb Michael Wayne SVP and CFO Feb 22, 2019 Sale 948,500
Kalb Michael Wayne SVP and CFO Feb 15, 2019 Sale 439,525
THERO JOHN F President and CEO Jan 31, 2019 Option Exercise 2,425,418
Ketchum Steven B Chief Scientific Officer Jan 31, 2019 Option Exercise 685,765
Ketchum Steven B Chief Scientific Officer Jan 31, 2019 Option Exercise 22,235
Ketchum Steven B Chief Scientific Officer Feb 01, 2019 Sale 477,498
Ketchum Steven B Chief Scientific Officer Jan 31, 2019 Sale 166,875
Kennedy Joseph T General Counsel Jan 31, 2019 Option Exercise 744,716
Kennedy Joseph T General Counsel Jan 31, 2019 Option Exercise 71,910
Kennedy Joseph T General Counsel Jan 31, 2019 Sale 745,468
Kalb Michael Wayne SVP and CFO Jan 31, 2019 Option Exercise 456,279
Kennedy Joseph T General Counsel Jan 23, 2019 Option Exercise 1,840,134
Kennedy Joseph T General Counsel Jan 22, 2019 Option Exercise 804,656
Kennedy Joseph T General Counsel Jan 24, 2019 Option Exercise 2,370,612
Kennedy Joseph T General Counsel Jan 22, 2019 Sale 3,141,884
Kennedy Joseph T General Counsel Jan 24, 2019 Sale 10,754,717
Kennedy Joseph T General Counsel Jan 23, 2019 Sale 4,591,310
Zakrzewski Joseph S Director Jan 10, 2019 Option Exercise 680,000
Zakrzewski Joseph S Director Jan 10, 2019 Sale 3,396,390
STACK DAVID M Director Jan 10, 2019 Option Exercise 79,172
STACK DAVID M Director Jan 10, 2019 Option Exercise 577,855
STACK DAVID M Director Jan 10, 2019 Sale 1,774,296
STACK DAVID M Director Jan 10, 2019 Sale 484,776
Kennedy Joseph T General Counsel Jan 11, 2019 Option Exercise 9,360
Kennedy Joseph T General Counsel Jan 11, 2019 Sale 60,033
Kalb Michael Wayne SVP and CFO Jan 09, 2019 Option Exercise 438,000
Kalb Michael Wayne SVP and CFO Jan 09, 2019 Sale 3,051,080
Ekman Lars Director Jan 10, 2019 Option Exercise 103,428
Ekman Lars Director Jan 10, 2019 Sale 2,426,489
Zakrzewski Joseph S Director Jan 02, 2019 Option Exercise 1,237,250
Zakrzewski Joseph S Director Dec 28, 2018 Sale 1,866,668
Zakrzewski Joseph S Director Jan 02, 2019 Sale 5,015,703
Kennedy Joseph T General Counsel Dec 31, 2018 Option Exercise 350,794
Kennedy Joseph T General Counsel Dec 31, 2018 Sale 363,547
Ketchum Steven B Chief Scientific Officer Dec 31, 2018 Option Exercise 40,985
Ketchum Steven B Chief Scientific Officer Dec 31, 2018 Sale 230,212
THERO JOHN F President and CEO Dec 31, 2018 Option Exercise 195,383
Ketchum Steven B Chief Scientific Officer Nov 30, 2018 Option Exercise 40,988
Ketchum Steven B Chief Scientific Officer Nov 30, 2018 Sale 303,174
Kennedy Joseph T General Counsel Nov 30, 2018 Option Exercise 52,510
Kennedy Joseph T General Counsel Nov 30, 2018 Sale 414,998
THERO JOHN F President and CEO Nov 12, 2018 Option Exercise 550,275
THERO JOHN F President and CEO Nov 12, 2018 Sale 11,587,896
Ketchum Steven B Chief Scientific Officer Oct 31, 2018 Option Exercise 40,988
Ketchum Steven B Chief Scientific Officer Oct 31, 2018 Sale 353,454
Kennedy Joseph T General Counsel Oct 31, 2018 Option Exercise 52,513
Kennedy Joseph T General Counsel Oct 31, 2018 Sale 483,362
THERO JOHN F President and CEO Sep 30, 2018 Option Exercise 240,096
Ketchum Steven B Chief Scientific Officer Sep 28, 2018 Option Exercise 1,754,000
Ketchum Steven B Chief Scientific Officer Oct 01, 2018 Option Exercise 916,893
Ketchum Steven B Chief Scientific Officer Sep 28, 2018 Sale 3,100,000
Ketchum Steven B Chief Scientific Officer Oct 01, 2018 Sale 2,005,589
Kennedy Joseph T General Counsel Sep 30, 2018 Option Exercise 431,074
Kennedy Joseph T General Counsel Oct 01, 2018 Option Exercise 52,510
Kennedy Joseph T General Counsel Oct 01, 2018 Sale 844,528
Zakrzewski Joseph S Director Sep 24, 2018 Option Exercise 1,700,000
Zakrzewski Joseph S Director Sep 24, 2018 Sale 5,299,334
Ketchum Steven B Chief Scientific Officer Sep 25, 2018 Option Exercise 1,754,000
Ketchum Steven B Chief Scientific Officer Sep 24, 2018 Option Exercise 2,366,711
Ketchum Steven B Chief Scientific Officer Sep 24, 2018 Sale 7,060,024
Ketchum Steven B Chief Scientific Officer Sep 25, 2018 Sale 2,700,000
Kennedy Joseph T General Counsel Sep 24, 2018 Option Exercise 2,393,014
Kennedy Joseph T General Counsel Sep 24, 2018 Sale 11,400,975
Kalb Michael Wayne SVP and CFO Sep 24, 2018 Option Exercise 328,500
Kalb Michael Wayne SVP and CFO Sep 24, 2018 Sale 1,562,751
THERO JOHN F President and CEO Sep 22, 2018 Option Exercise 1,488,649
THERO JOHN F President and CEO Jun 30, 2018 Option Exercise 45,599
Kennedy Joseph T General Counsel Jun 30, 2018 Option Exercise 81,870
Kennedy Joseph T General Counsel Jul 02, 2018 Sale 80,955
THERO JOHN F President and CEO Mar 31, 2018 Option Exercise 44,419
Kennedy Joseph T General Counsel Mar 31, 2018 Option Exercise 79,750
Kennedy Joseph T General Counsel Apr 03, 2018 Sale 55,052
Kennedy Joseph T General Counsel Apr 02, 2018 Sale 23,020
THERO JOHN F President and CEO Jan 31, 2018 Option Exercise 756,475
Ketchum Steven B Chief Scientific Officer Jan 31, 2018 Option Exercise 219,949
Kennedy Joseph T General Counsel Jan 31, 2018 Option Exercise 230,999
Kennedy Joseph T General Counsel Jan 31, 2018 Sale 167,388
Kalb Michael Wayne SVP and CFO Jan 31, 2018 Option Exercise 53,635
Ketchum Steven B Chief Scientific Officer Jan 23, 2018 Option Exercise 275,818
Ketchum Steven B Chief Scientific Officer Jan 23, 2018 Sale 596,430
Kennedy Joseph T General Counsel Jan 12, 2018 Sale 41,128
Kennedy Joseph T General Counsel Jan 17, 2018 Sale 127,022
Kennedy Joseph T General Counsel Jan 16, 2018 Sale 41,300
Ketchum Steven B Chief Scientific Officer Jan 11, 2018 Option Exercise 5,328
Ketchum Steven B Chief Scientific Officer Jan 11, 2018 Sale 11,493
Ketchum Steven B Chief Scientific Officer Jan 05, 2018 Option Exercise 131,953
Ketchum Steven B Chief Scientific Officer Jan 05, 2018 Sale 284,631
Ketchum Steven B Chief Scientific Officer Jan 02, 2018 Option Exercise 153,583
Ketchum Steven B Chief Scientific Officer Jan 02, 2018 Sale 545,092
THERO JOHN F President and CEO Dec 31, 2017 Option Exercise 63,085
Kennedy Joseph T General Counsel Dec 31, 2017 Option Exercise 111,819
THERO JOHN F President and CEO Nov 30, 2017 Buy 32,446
Ketchum Steven B Chief Scientific Officer Oct 05, 2017 Sale 221,199
THERO JOHN F President and CEO Sep 30, 2017 Option Exercise 55,062
Kennedy Joseph T General Counsel Sep 30, 2017 Option Exercise 97,598
THERO JOHN F President and CEO Jun 30, 2017 Option Exercise 63,400
Kennedy Joseph T General Counsel Jun 30, 2017 Option Exercise 112,377
Kennedy Joseph T General Counsel Jun 29, 2017 Sale 603,824
Kennedy Joseph T General Counsel Jul 03, 2017 Sale 209,158
Kennedy Joseph T General Counsel Jun 30, 2017 Sale 417,950
Kennedy Joseph T General Counsel Mar 31, 2017 Option Exercise 86,339
THERO JOHN F President and CEO Mar 31, 2017 Option Exercise 50,342
THERO JOHN F President and CEO Jan 31, 2017 Option Exercise 688,202
Ketchum Steven B Chief Scientific Officer Jan 31, 2017 Option Exercise 208,601
Kennedy Joseph T General Counsel Jan 31, 2017 Option Exercise 225,349
Kennedy Joseph T General Counsel Dec 31, 2016 Option Exercise 85,886
THERO JOHN F President and CEO Dec 31, 2016 Option Exercise 62,198
Kennedy Joseph T General Counsel Nov 09, 2016 Sale 372,042
Kennedy Joseph T General Counsel Sep 30, 2016 Option Exercise 88,953
THERO JOHN F President and CEO Sep 30, 2016 Option Exercise 64,419
THERO JOHN F President and CEO Jun 30, 2016 Option Exercise 31,793
Kennedy Joseph T General Counsel Jun 30, 2016 Option Exercise 60,232
Kennedy Joseph T General Counsel Mar 31, 2016 Option Exercise 30,725
THERO JOHN F President and CEO Mar 31, 2016 Option Exercise 22,520
THERO JOHN F President and CEO Feb 01, 2016 Buy 34,250
THERO JOHN F President and CEO Jan 31, 2016 Option Exercise 234,134
Ketchum Steven B Chief Scientific Officer Jan 31, 2016 Option Exercise 57,842
Kennedy Joseph T General Counsel Jan 31, 2016 Option Exercise 64,710
Farrell Michael James VP, Finance Jan 31, 2016 Option Exercise 15,772
Kennedy Joseph T General Counsel Dec 31, 2015 Option Exercise 37,955
Kennedy Joseph T General Counsel Oct 05, 2015 Option Exercise 4,815
Kennedy Joseph T General Counsel Sep 30, 2015 Option Exercise 34,227
THERO JOHN F President and CEO Aug 11, 2015 Buy 47,000
Farrell Michael James Controller Nov 11, 2014 Buy 4,606
THERO JOHN F President, Chief Exec. Officer Nov 12, 2014 Buy 17,600
THERO JOHN F President, Chief Exec. Officer Nov 11, 2014 Buy 24,000
Ekman Lars Director Nov 20, 2013 Buy 72,000
THERO JOHN F President Nov 20, 2013 Buy 9,500
Zakrzewski Joseph S Chief Executive Officer Nov 18, 2013 Buy 78,197
VAN HEEK G JAN Director Jul 10, 2013 Option Exercise 9,810
Zakrzewski Joseph S Chief Executive Officer Jun 25, 2013 Option Exercise 13,500
Zakrzewski Joseph S Chief Executive Officer Jun 21, 2013 Option Exercise 13,500
THERO JOHN F President May 29, 2013 Option Exercise 14,850
Zakrzewski Joseph S Chief Executive Officer Apr 25, 2013 Option Exercise 13,500
VAN HEEK G JAN Director Apr 10, 2013 Option Exercise 9,808
THERO JOHN F President Jan 30, 2013 Option Exercise 13,500
VAN HEEK G JAN Director Jan 10, 2013 Option Exercise 7,935
VAN HEEK G JAN Director Oct 10, 2012 Option Exercise 7,930
Zakrzewski Joseph S Chief Executive Officer Oct 01, 2012 Option Exercise 202,500
Zakrzewski Joseph S Chief Executive Officer Oct 01, 2012 Sale 1,884,315
THERO JOHN F President Sep 24, 2012 Option Exercise 13,500
THERO JOHN F President Sep 11, 2012 Option Exercise 13,500
HEALY JAMES Director Aug 31, 2012 Option Exercise 30,900
GORDON CARL L Director Sep 04, 2012 Sale 3,372,992
ORBIMED ADVISORS LLC Director Sep 04, 2012 Sale 3,372,992
HEALY JAMES Director Aug 14, 2012 Option Exercise 1,212,300
GORDON CARL L Director Jul 27, 2012 Sale 5,350,691
ORBIMED ADVISORS LLC Director Jul 27, 2012 Sale 50,483
ORBIMED ADVISORS LLC Director Jul 27, 2012 Sale 5,300,207
Zakrzewski Joseph S Chief Executive Officer Jul 27, 2012 Option Exercise 202,500
Zakrzewski Joseph S Chief Executive Officer Jul 27, 2012 Sale 2,147,192
THERO JOHN F President Jul 27, 2012 Option Exercise 713,750
THERO JOHN F President Jul 27, 2012 Sale 4,315,862
Kennedy Joseph T Senior VP and General Counsel Jul 27, 2012 Sale 96,290
Huff Paul Chief Commercial Officer Jul 27, 2012 Sale 96,290
SEDLACK STUART D Senior Vice President Jul 27, 2012 Sale 96,290
VAN HEEK G JAN Director Jul 10, 2012 Option Exercise 7,934
Huff Paul Chief Commercial Officer Jun 26, 2012 Option Exercise 9,669
Huff Paul Chief Commercial Officer Jun 27, 2012 Option Exercise 429,831
Huff Paul Chief Commercial Officer Jun 27, 2012 Sale 734,204
Huff Paul Chief Commercial Officer Jun 26, 2012 Sale 14,870
GORDON CARL L Director Jun 19, 2012 Sale 7,986,701
ORBIMED ADVISORS LLC Director Jun 19, 2012 Sale 76,185
ORBIMED ADVISORS LLC Director Jun 19, 2012 Sale 7,892,242
Huff Paul Chief Commercial Officer Jun 15, 2012 Option Exercise 879
Huff Paul Chief Commercial Officer Jun 18, 2012 Option Exercise 1,432,111
Huff Paul Chief Commercial Officer Jun 15, 2012 Sale 1,200
Huff Paul Chief Commercial Officer Jun 18, 2012 Sale 1,955,524
Huff Paul Chief Commercial Officer Jun 07, 2012 Option Exercise 111,008
Huff Paul Chief Commercial Officer Jun 07, 2012 Sale 201,635
Zakrzewski Joseph S Chief Executive Officer May 29, 2012 Option Exercise 202,500
Zakrzewski Joseph S Chief Executive Officer May 29, 2012 Sale 1,795,215
Abingworth LLP 10% Owner Apr 17, 2012 Sale 16,454,204
Abingworth LLP 10% Owner Apr 19, 2012 Sale 6,586,347
Abingworth LLP 10% Owner Apr 18, 2012 Sale 15,505,584
Abingworth LLP 10% Owner Apr 19, 2012 Sale 6,586,347
Abingworth LLP 10% Owner Apr 18, 2012 Sale 15,505,584
Abingworth LLP 10% Owner Apr 17, 2012 Sale 16,454,204
VAN HEEK G JAN Director Apr 10, 2012 Option Exercise 7,929
THERO JOHN F President Apr 09, 2012 Option Exercise 203,750
THERO JOHN F President Apr 09, 2012 Sale 1,503,072
Abingworth LLP 10% Owner Apr 03, 2012 Sale 25,300,000
HEALY JAMES Director Apr 02, 2012 Sale 2,905,286
HEALY JAMES Director Apr 03, 2012 Sale 19,059,665
HEALY JAMES Director Mar 29, 2012 Sale 10,910,804
HEALY JAMES Director Mar 28, 2012 Sale 73,922
Zakrzewski Joseph S Chief Executive Officer Mar 23, 2012 Option Exercise 216,000
Zakrzewski Joseph S Chief Executive Officer Mar 23, 2012 Sale 1,854,560
HEALY JAMES Director Jan 27, 2012 Option Exercise 61,800
VAN HEEK G JAN Director Jan 10, 2012 Option Exercise 6,312
Zakrzewski Joseph S Chief Executive Officer Nov 07, 2011 Option Exercise 6,750
VAN HEEK G JAN Director Oct 11, 2011 Option Exercise 6,307
Anderson Joseph Director Oct 11, 2011 Option Exercise 7,879
Zakrzewski Joseph S Chief Executive Officer Aug 22, 2011 Option Exercise 6,750
Zakrzewski Joseph S Chief Executive Officer Jul 15, 2011 Option Exercise 6,750
Zakrzewski Joseph S Chief Executive Officer Jul 15, 2011 Option Exercise 6,750
VAN HEEK G JAN Director Jul 11, 2011 Option Exercise 6,310
Anderson Joseph Director Jul 11, 2011 Option Exercise 6,636
Anderson Joseph Director Jul 12, 2010 Option Exercise 6,386
Anderson Joseph Director Apr 12, 2010 Option Exercise 6,386
Anderson Joseph Director Apr 11, 2011 Option Exercise 6,384
Anderson Joseph Director Jan 10, 2011 Option Exercise 6,378
Anderson Joseph Director Oct 11, 2010 Option Exercise 6,387
VAN HEEK G JAN Director Apr 11, 2011 Option Exercise 6,307
ORBIMED ADVISORS LLC Director May 02, 2011 Sale 4,890
ORBIMED ADVISORS LLC Director May 02, 2011 Sale 531,380
ORBIMED ADVISORS LLC Director Apr 29, 2011 Sale 16,010
ORBIMED ADVISORS LLC Director Apr 29, 2011 Sale 1,584,990
GORDON CARL L Director Apr 29, 2011 Sale 1,601,000
GORDON CARL L Director May 02, 2011 Sale 536,270
VAN HEEK G JAN Director Apr 25, 2011 Option Exercise 30,900
VAN HEEK G JAN Director Apr 25, 2011 Sale 497,379
VAN HEEK G JAN Director Apr 18, 2011 Sale 3,090
ORBIMED ADVISORS LLC Director Apr 20, 2011 Sale 120,004
ORBIMED ADVISORS LLC Director Apr 20, 2011 Sale 12,511,996
GORDON CARL L Director Apr 20, 2011 Sale 120,004
GORDON CARL L Director Apr 20, 2011 Sale 12,511,996
GORDON CARL L Director Apr 21, 2011 Sale 12,500,000
ORBIMED ADVISORS LLC Director Apr 21, 2011 Sale 118,333
ORBIMED ADVISORS LLC Director Apr 21, 2011 Sale 12,381,667
GORDON CARL L Director Apr 18, 2011 Sale 45,549,897
GORDON CARL L Director Apr 20, 2011 Sale 12,632,000
ORBIMED ADVISORS LLC Director Apr 20, 2011 Sale 12,632,000
ORBIMED ADVISORS LLC Director Apr 18, 2011 Sale 428,168
ORBIMED ADVISORS LLC Director Apr 18, 2011 Sale 45,121,729
Zakrzewski Joseph S Chief Executive Officer Apr 18, 2011 Option Exercise 815,000
Zakrzewski Joseph S Chief Executive Officer Apr 18, 2011 Sale 4,728,210
VAN HEEK G JAN Director Apr 18, 2011 Option Exercise 3,090
VAN HEEK G JAN Director Apr 18, 2011 Sale 49,530
Soni Paresh SVP and Head of Development Apr 19, 2011 Option Exercise 108,000
Soni Paresh SVP and Head of Development Apr 19, 2011 Sale 1,208,624
Ahlholm Frederick W Vice President Finance Apr 20, 2011 Option Exercise 53,125
Ahlholm Frederick W Vice President Finance Apr 20, 2011 Sale 496,344
Abingworth LLP 10% Owner Apr 18, 2011 Sale 62,143,480
Ahlholm Frederick W Vice President Finance Apr 04, 2011 Option Exercise 53,125
Ahlholm Frederick W Vice President Finance Apr 04, 2011 Sale 233,688
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 29, 2011 Sale 3,080,610
GORDON CARL L Director Mar 28, 2011 Sale 684,285
GORDON CARL L Director Mar 25, 2011 Sale 425,043
GORDON CARL L Director Mar 24, 2011 Sale 172,500
ORBIMED ADVISORS LLC Director Mar 24, 2011 Sale 171,000
ORBIMED ADVISORS LLC Director Mar 28, 2011 Sale 677,670
ORBIMED ADVISORS LLC Director Mar 25, 2011 Sale 3,735
ORBIMED ADVISORS LLC Director Mar 25, 2011 Sale 421,308
ORBIMED ADVISORS LLC Director Mar 24, 2011 Sale 1,500
ORBIMED ADVISORS LLC Director Mar 28, 2011 Sale 6,615
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 25, 2011 Sale 563,333
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 24, 2011 Sale 3,778,000
GORDON CARL L Director Mar 21, 2011 Sale 542,850
ORBIMED ADVISORS LLC Director Mar 21, 2011 Sale 4,935
ORBIMED ADVISORS LLC Director Mar 21, 2011 Sale 537,915
GORDON CARL L Director Mar 11, 2011 Sale 743,000
GORDON CARL L Director Mar 15, 2011 Sale 362,000
GORDON CARL L Director Mar 14, 2011 Sale 549,750
ORBIMED ADVISORS LLC Director Mar 14, 2011 Sale 544,619
ORBIMED ADVISORS LLC Director Mar 15, 2011 Sale 3,620
ORBIMED ADVISORS LLC Director Mar 11, 2011 Sale 6,687
ORBIMED ADVISORS LLC Director Mar 15, 2011 Sale 358,380
ORBIMED ADVISORS LLC Director Mar 11, 2011 Sale 736,313
ORBIMED ADVISORS LLC Director Mar 14, 2011 Sale 5,131
Abingworth LLP 10% Owner Mar 11, 2011 Sale 20,636,001
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 11, 2011 Sale 15,000,000
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 10, 2011 Sale 4,400,283
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Mar 09, 2011 Sale 222,575
Abingworth LLP 10% Owner Mar 08, 2011 Sale 4,125,990
Zakrzewski Joseph S Chief Executive Officer Mar 09, 2011 Option Exercise 13,500
Abingworth LLP 10% Owner Mar 04, 2011 Sale 760,000
GORDON CARL L Director Mar 07, 2011 Sale 192,000
GORDON CARL L Director Mar 04, 2011 Sale 327,660
GORDON CARL L Director Mar 03, 2011 Sale 54,320
ORBIMED ADVISORS LLC Director Mar 03, 2011 Sale 776
ORBIMED ADVISORS LLC Director Mar 07, 2011 Sale 1,536
ORBIMED ADVISORS LLC Director Mar 03, 2011 Sale 53,544
ORBIMED ADVISORS LLC Director Mar 07, 2011 Sale 190,464
ORBIMED ADVISORS LLC Director Mar 04, 2011 Sale 3,048
ORBIMED ADVISORS LLC Director Mar 04, 2011 Sale 324,612
Abingworth LLP 10% Owner Mar 02, 2011 Sale 9,239,040
ORBIMED ADVISORS LLC Director Feb 28, 2011 Sale 766,043
ORBIMED ADVISORS LLC Director Mar 02, 2011 Sale 726,452
ORBIMED ADVISORS LLC Director Mar 01, 2011 Sale 3,780
ORBIMED ADVISORS LLC Director Mar 01, 2011 Sale 374,220
ORBIMED ADVISORS LLC Director Feb 28, 2011 Sale 6,957
ORBIMED ADVISORS LLC Director Mar 02, 2011 Sale 6,948
GORDON CARL L Director Mar 02, 2011 Sale 733,400
GORDON CARL L Director Mar 01, 2011 Sale 378,000
GORDON CARL L Director Feb 28, 2011 Sale 773,000
Abingworth LLP 10% Owner Mar 01, 2011 Sale 380,485
Abingworth LLP 10% Owner Feb 28, 2011 Sale 2,178,137
SOFINNOVA VENTURE PARTNERS VII L P 10% Owner Feb 25, 2011 Sale 2,952,787
Zakrzewski Joseph S Chief Executive Officer Feb 25, 2011 Option Exercise 81,000
Zakrzewski Joseph S Chief Executive Officer Feb 25, 2011 Sale 489,755
Zakrzewski Joseph S Chief Executive Officer Feb 22, 2011 Option Exercise 135,000
Zakrzewski Joseph S Chief Executive Officer Feb 22, 2011 Sale 854,060
Soni Paresh SVP and Head of Development Feb 22, 2011 Option Exercise 162,000
Soni Paresh SVP and Head of Development Feb 22, 2011 Sale 1,018,764