| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| EFTR | Director | Jun 23, 2022 | Buy | $1.59 | 30,000 | 47,700 | 30,000 | Jun 27, 2022, 06:00 AM |
| TBIO | Director | Jul 02, 2018 | Buy | $13.00 | 269,230 | 3,499,990 | 3,697,912 | Jul 05, 2018, 04:30 PM |
| ALRN | Director | Jul 05, 2017 | Buy | $15.00 | 273,333 | 4,099,995 | 1,431,519 | Jul 06, 2017, 06:26 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| EFTR | Director | Jun 23, 2022 | Buy | 47,700 |
| TBIO | Director | Jul 02, 2018 | Buy | 3,499,990 |
| ALRN | Director | Jul 05, 2017 | Buy | 4,099,995 |