| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2022 | Option Exercise | $232.00 | 2,243 | 520,376 | 29,599 | Mar 17, 2022, 04:43 PM |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2022 | Option Exercise | $232.00 | 749 | 173,768 | 28,850 | Mar 17, 2022, 04:43 PM |
| CME | Sr MD Chief Commercial Officer | Sep 16, 2021 | Option Exercise | $188.69 | 315 | 59,437 | 27,356 | Sep 17, 2021, 03:31 PM |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2021 | Option Exercise | $188.96 | 780 | 147,389 | 24,703 | Sep 16, 2021, 12:54 PM |
| CME | Sr MD Chief Commercial Officer | Sep 14, 2021 | Option Exercise | $188.85 | 321 | 60,621 | 25,079 | Sep 16, 2021, 12:54 PM |
| CME | Sr MD Chief Commercial Officer | May 27, 2021 | Sale | $217.00 | 3,500 | 759,500 | 25,400 | Jun 01, 2021, 05:05 PM |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2021 | Option Exercise | $209.09 | 6,578 | 1,375,394 | 31,499 | Mar 17, 2021, 08:27 PM |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2021 | Option Exercise | $209.09 | 2,599 | 543,425 | 28,999 | Mar 17, 2021, 08:27 PM |
| CME | Sr MD Chief Commercial Officer | Dec 14, 2020 | Sale | $181.02 | 4,059 | 734,760 | 24,921 | Dec 15, 2020, 06:07 PM |
| CME | Sr MD Chief Commercial Officer | Sep 16, 2020 | Option Exercise | $170.20 | 327 | 55,655 | 28,980 | Sep 17, 2020, 06:03 PM |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2020 | Option Exercise | $168.10 | 577 | 96,994 | 25,903 | Sep 16, 2020, 09:33 PM |
| CME | Sr MD Chief Commercial Officer | Sep 14, 2020 | Option Exercise | $166.08 | 332 | 55,139 | 26,092 | Sep 16, 2020, 09:33 PM |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2020 | Option Exercise | $182.01 | 3,600 | 655,236 | 26,602 | Mar 17, 2020, 04:53 PM |
| CME | Sr MD Chief Commercial Officer | Feb 24, 2020 | Option Exercise | $54.37 | 5,620 | 305,559 | 25,114 | Feb 26, 2020, 02:34 PM |
| CME | Sr MD Chief Commercial Officer | Feb 24, 2020 | Sale | $210.97 | 5,620 | 1,185,667 | 22,304 | Feb 26, 2020, 02:34 PM |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2019 | Option Exercise | $205.80 | 836 | 172,049 | 19,842 | Sep 17, 2019, 06:35 PM |
| CME | Sr MD Chief Commercial Officer | Sep 14, 2019 | Option Exercise | $205.80 | 350 | 72,030 | 20,060 | Sep 17, 2019, 06:35 PM |
| CME | Sr MD Chief Commercial Officer | Jun 12, 2019 | Option Exercise | $54.30 | 2,670 | 144,981 | 25,177 | Jun 13, 2019, 02:53 PM |
| CME | Sr MD Chief Commercial Officer | Jun 12, 2019 | Sale | $198.03 | 4,767 | 944,009 | 22,507 | Jun 13, 2019, 02:53 PM |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2019 | Option Exercise | $170.14 | 1,755 | 298,596 | 22,692 | Mar 19, 2019, 08:37 PM |
| CME | Sr MD Chief Commercial Officer | Nov 16, 2018 | Option Exercise | $55.15 | 3,980 | 219,481 | 24,255 | Nov 20, 2018, 01:19 PM |
| CME | Sr MD Chief Commercial Officer | Nov 16, 2018 | Sale | $195.01 | 5,847 | 1,140,223 | 21,585 | Nov 20, 2018, 01:19 PM |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2018 | Option Exercise | $173.15 | 1,098 | 190,119 | 22,462 | Sep 18, 2018, 06:14 PM |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2018 | Option Exercise | $165.66 | 1,705 | 282,450 | 19,627 | Mar 19, 2018, 06:32 PM |
| CME | Sr MD Chief Commercial Officer | Dec 07, 2017 | Sale | $150.41 | 2,457 | 369,557 | 16,318 | Dec 11, 2017, 02:49 PM |
| CME | Sr MD Chief Commercial Officer | Sep 16, 2017 | Option Exercise | $131.29 | 116 | 15,230 | 18,775 | Sep 19, 2017, 02:39 PM |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2017 | Option Exercise | $131.29 | 464 | 60,919 | 18,891 | Sep 19, 2017, 02:39 PM |
| CME | Sr MD Chief Commercial Officer | Jun 12, 2017 | Option Exercise | $83.88 | 3,420 | 286,870 | 19,670 | Jun 13, 2017, 03:52 PM |
| CME | Sr MD Chief Commercial Officer | Jun 12, 2017 | Sale | $124.95 | 4,315 | 539,149 | 16,250 | Jun 13, 2017, 03:52 PM |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2017 | Option Exercise | $124.74 | 432 | 53,888 | 13,054 | Mar 17, 2017, 06:38 PM |
| CME | Sr MD Chief Commercial Officer | Feb 24, 2017 | Option Exercise | $103.80 | 3,730 | 387,162 | 16,361 | Feb 28, 2017, 12:06 PM |
| CME | Sr MD Chief Commercial Officer | Feb 24, 2017 | Sale | $122.53 | 5,888 | 721,464 | 14,095 | Feb 28, 2017, 12:06 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2022 | Option Exercise | 520,376 |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2022 | Option Exercise | 173,768 |
| CME | Sr MD Chief Commercial Officer | Sep 16, 2021 | Option Exercise | 59,437 |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2021 | Option Exercise | 147,389 |
| CME | Sr MD Chief Commercial Officer | Sep 14, 2021 | Option Exercise | 60,621 |
| CME | Sr MD Chief Commercial Officer | May 27, 2021 | Sale | 759,500 |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2021 | Option Exercise | 1,375,394 |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2021 | Option Exercise | 543,425 |
| CME | Sr MD Chief Commercial Officer | Dec 14, 2020 | Sale | 734,760 |
| CME | Sr MD Chief Commercial Officer | Sep 16, 2020 | Option Exercise | 55,655 |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2020 | Option Exercise | 96,994 |
| CME | Sr MD Chief Commercial Officer | Sep 14, 2020 | Option Exercise | 55,139 |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2020 | Option Exercise | 655,236 |
| CME | Sr MD Chief Commercial Officer | Feb 24, 2020 | Option Exercise | 305,559 |
| CME | Sr MD Chief Commercial Officer | Feb 24, 2020 | Sale | 1,185,667 |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2019 | Option Exercise | 172,049 |
| CME | Sr MD Chief Commercial Officer | Sep 14, 2019 | Option Exercise | 72,030 |
| CME | Sr MD Chief Commercial Officer | Jun 12, 2019 | Option Exercise | 144,981 |
| CME | Sr MD Chief Commercial Officer | Jun 12, 2019 | Sale | 944,009 |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2019 | Option Exercise | 298,596 |
| CME | Sr MD Chief Commercial Officer | Nov 16, 2018 | Option Exercise | 219,481 |
| CME | Sr MD Chief Commercial Officer | Nov 16, 2018 | Sale | 1,140,223 |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2018 | Option Exercise | 190,119 |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2018 | Option Exercise | 282,450 |
| CME | Sr MD Chief Commercial Officer | Dec 07, 2017 | Sale | 369,557 |
| CME | Sr MD Chief Commercial Officer | Sep 16, 2017 | Option Exercise | 15,230 |
| CME | Sr MD Chief Commercial Officer | Sep 15, 2017 | Option Exercise | 60,919 |
| CME | Sr MD Chief Commercial Officer | Jun 12, 2017 | Option Exercise | 286,870 |
| CME | Sr MD Chief Commercial Officer | Jun 12, 2017 | Sale | 539,149 |
| CME | Sr MD Chief Commercial Officer | Mar 15, 2017 | Option Exercise | 53,888 |
| CME | Sr MD Chief Commercial Officer | Feb 24, 2017 | Option Exercise | 387,162 |
| CME | Sr MD Chief Commercial Officer | Feb 24, 2017 | Sale | 721,464 |