| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| AGLE | Director | Dec 13, 2021 | Buy | $3.65 | 14,685 | 53,600 | 150,000 | Dec 13, 2021, 08:41 PM |
| AGLE | Director | Dec 10, 2021 | Buy | $3.65 | 13,516 | 49,333 | 135,315 | Dec 13, 2021, 08:41 PM |
| AGLE | Director | Dec 09, 2021 | Buy | $3.67 | 121,799 | 446,759 | 121,799 | Dec 13, 2021, 08:41 PM |
| SURF | Director | Apr 23, 2018 | Buy | $15.00 | 266,000 | 3,990,000 | 3,447,817 | Apr 23, 2018, 04:16 PM |
| ALRN | Director | Jul 05, 2017 | Buy | $15.00 | 250,000 | 3,750,000 | 1,094,987 | Jul 07, 2017, 07:18 PM |
| PTGX | Director | Aug 16, 2016 | Buy | $12.00 | 583,333 | 6,999,996 | 2,099,482 | Aug 16, 2016, 06:20 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| AGLE | Director | Dec 13, 2021 | Buy | 53,600 |
| AGLE | Director | Dec 10, 2021 | Buy | 49,333 |
| AGLE | Director | Dec 09, 2021 | Buy | 446,759 |
| SURF | Director | Apr 23, 2018 | Buy | 3,990,000 |
| ALRN | Director | Jul 05, 2017 | Buy | 3,750,000 |
| PTGX | Director | Aug 16, 2016 | Buy | 6,999,996 |