| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| AKBA | SVP, Chief Medical Officer | Mar 01, 2022 | Sale | $2.17 | 7,656 | 16,619 | 217,663 | Mar 02, 2022, 09:12 PM |
| AKBA | SVP, Chief Medical Officer | Feb 28, 2022 | Sale | $2.15 | 7,400 | 15,946 | 163,819 | Mar 02, 2022, 09:12 PM |
| AKBA | SVP, Chief Medical Officer | Aug 31, 2021 | Sale | $2.83 | 1,042 | 2,949 | 171,219 | Sep 02, 2021, 04:07 PM |
| AKBA | SVP, Chief Medical Officer | Apr 01, 2021 | Sale | $3.40 | 1,081 | 3,675 | 170,761 | Apr 01, 2021, 08:31 PM |
| AKBA | SVP, Chief Medical Officer | Mar 01, 2021 | Sale | $3.40 | 7,558 | 25,668 | 161,442 | Mar 02, 2021, 04:06 PM |
| AKBA | SVP, Chief Medical Officer | Nov 20, 2019 | Buy | $3.58 | 27,000 | 96,660 | 37,000 | Nov 22, 2019, 06:19 AM |
| PRTO | SVP and Chief Medical Officer | Dec 31, 2018 | Option Exercise | $1.93 | 2,448 | 4,725 | 123,917 | Jan 03, 2019, 08:19 AM |
| PRTO | SVP and Chief Medical Officer | Jun 29, 2018 | Option Exercise | $1.62 | 10,000 | 16,150 | 121,469 | Jul 03, 2018, 08:19 AM |
| PRTO | SVP and Chief Medical Officer | Dec 29, 2017 | Option Exercise | $1.30 | 3,934 | 5,098 | 111,469 | Jan 03, 2018, 08:15 AM |
| PRTO | SVP and Chief Medical Officer | Dec 15, 2017 | Buy | $1.88 | 12,000 | 22,560 | 117,535 | Dec 18, 2017, 05:11 PM |
| PRTO | SVP and Chief Medical Officer | Jun 30, 2017 | Option Exercise | $1.30 | 10,000 | 12,960 | 105,535 | Jul 05, 2017, 12:00 AM |
| PRTO | SVP and Chief Medical Officer | Mar 10, 2017 | Option Exercise | $1.46 | 70,221 | 102,819 | 95,535 | Mar 13, 2017, 05:00 PM |
| PRTO | SVP & Chief Medical Officer | Jun 30, 2015 | Option Exercise | $8.84 | 2,403 | 21,243 | 32,814 | Jul 08, 2015, 08:00 AM |
| Symbol | Relationship | Date | Transaction | Value($) |
| AKBA | SVP, Chief Medical Officer | Mar 01, 2022 | Sale | 16,619 |
| AKBA | SVP, Chief Medical Officer | Feb 28, 2022 | Sale | 15,946 |
| AKBA | SVP, Chief Medical Officer | Aug 31, 2021 | Sale | 2,949 |
| AKBA | SVP, Chief Medical Officer | Apr 01, 2021 | Sale | 3,675 |
| AKBA | SVP, Chief Medical Officer | Mar 01, 2021 | Sale | 25,668 |
| AKBA | SVP, Chief Medical Officer | Nov 20, 2019 | Buy | 96,660 |
| PRTO | SVP and Chief Medical Officer | Dec 31, 2018 | Option Exercise | 4,725 |
| PRTO | SVP and Chief Medical Officer | Jun 29, 2018 | Option Exercise | 16,150 |
| PRTO | SVP and Chief Medical Officer | Dec 29, 2017 | Option Exercise | 5,098 |
| PRTO | SVP and Chief Medical Officer | Dec 15, 2017 | Buy | 22,560 |
| PRTO | SVP and Chief Medical Officer | Jun 30, 2017 | Option Exercise | 12,960 |
| PRTO | SVP and Chief Medical Officer | Mar 10, 2017 | Option Exercise | 102,819 |
| PRTO | SVP & Chief Medical Officer | Jun 30, 2015 | Option Exercise | 21,243 |