| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| DRNA | Director | Dec 28, 2021 | Option Exercise | $38.25 | 3,333 | 127,487 | 0 | Dec 29, 2021, 04:21 PM |
| AKBA | Director | Jun 08, 2020 | Sale | $12.10 | 4,567 | 55,261 | 37,833 | Jun 09, 2020, 04:17 PM |
| AKBA | Director | Nov 20, 2019 | Buy | $3.52 | 15,000 | 52,800 | 28,700 | Nov 22, 2019, 06:20 AM |
| ZSPH | Chief Commercial Officer | Dec 17, 2015 | Option Exercise | $90.00 | 12,598 | 1,133,820 | 0 | Dec 21, 2015, 06:46 PM |
| ZSPH | Chief Commercial Officer | Dec 08, 2015 | Option Exercise | $10.92 | 9,155 | 100,011 | 9,155 | Dec 10, 2015, 09:23 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| DRNA | Director | Dec 28, 2021 | Option Exercise | 127,487 |
| AKBA | Director | Jun 08, 2020 | Sale | 55,261 |
| AKBA | Director | Nov 20, 2019 | Buy | 52,800 |
| ZSPH | Chief Commercial Officer | Dec 17, 2015 | Option Exercise | 1,133,820 |
| ZSPH | Chief Commercial Officer | Dec 08, 2015 | Option Exercise | 100,011 |