| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| ZYNE | Director | Jun 14, 2022 | Sale | $1.01 | 53 | 54 | 33,056 | Jun 16, 2022, 09:48 PM |
| AKBA | CEO and President | Feb 28, 2022 | Sale | $2.15 | 25,053 | 53,984 | 1,164,095 | Mar 02, 2022, 09:25 PM |
| AKBA | CEO and President | Mar 01, 2022 | Sale | $2.17 | 53,973 | 117,159 | 1,432,409 | Mar 02, 2022, 09:25 PM |
| AKBA | CEO and President | Apr 01, 2021 | Sale | $3.40 | 4,109 | 13,971 | 1,152,153 | Apr 01, 2021, 08:32 PM |
| AKBA | CEO and President | Mar 01, 2021 | Sale | $3.40 | 49,990 | 169,771 | 1,141,416 | Mar 02, 2021, 04:10 PM |
| AKBA | CEO and President | Nov 20, 2019 | Buy | $3.44 | 50,000 | 172,000 | 887,732 | Nov 21, 2019, 06:32 AM |
| AKBA | CEO and President | Jun 03, 2019 | Option Exercise | $0.47 | 287,000 | 134,890 | 836,232 | Jun 05, 2019, 04:05 PM |
| AKBA | CEO & President | Dec 12, 2018 | Option Exercise | $8.94 | 135,697 | 1,213,131 | 374,617 | Dec 13, 2018, 08:10 AM |
| ZYNE | Director | Aug 22, 2018 | Buy | $6.43 | 5,000 | 32,153 | 5,000 | Aug 22, 2018, 04:39 PM |
| AKBA | CEO and President | Jul 11, 2018 | Option Exercise | $0.47 | 100,000 | 47,000 | 510,314 | Jul 12, 2018, 04:59 PM |
| AKBA | CEO and President | Jan 19, 2017 | Option Exercise | $0.47 | 20,000 | 9,400 | 373,480 | Jan 23, 2017, 04:10 PM |
| RLYP | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,250 | 72,000 | 0 | Sep 02, 2016, 12:33 PM |
| RLYP | Director | Sep 01, 2016 | Option Exercise | $32.00 | 2,849 | 91,168 | 2,250 | Sep 02, 2016, 12:33 PM |
| RLYP | Director | Jun 07, 2016 | Sale | $19.32 | 1,013 | 19,570 | 2,849 | Jun 08, 2016, 05:19 PM |
| AKBA | CEO and President | Jan 15, 2016 | Option Exercise | $0.47 | 25,000 | 11,750 | 225,673 | Jan 19, 2016, 04:00 PM |
| RLYP | Director | Jun 11, 2015 | Sale | $34.62 | 1,100 | 38,087 | 3,862 | Jun 15, 2015, 06:40 PM |
| AKBA | CEO and President | May 26, 2015 | Option Exercise | $0.47 | 50,000 | 23,500 | 198,350 | May 28, 2015, 06:31 AM |
| AKBA | CEO and President | Mar 09, 2015 | Option Exercise | $0.47 | 100,000 | 47,000 | 148,350 | Mar 11, 2015, 06:23 AM |
| AKBA | CEO and President | Dec 29, 2014 | Buy | $11.57 | 1,000 | 11,567 | 48,350 | Dec 29, 2014, 05:16 PM |
| AKBA | CEO and President | Dec 22, 2014 | Buy | $11.92 | 1,000 | 11,916 | 47,350 | Dec 22, 2014, 04:11 PM |
| AKBA | CEO and President | Dec 15, 2014 | Buy | $11.34 | 1,000 | 11,336 | 46,350 | Dec 18, 2014, 04:02 PM |
| AKBA | CEO and President | Nov 11, 2014 | Option Exercise | $0.47 | 30,500 | 14,335 | 44,350 | Nov 13, 2014, 06:21 AM |
| AKBA | CEO and President | Nov 12, 2014 | Buy | $10.31 | 1,000 | 10,305 | 45,350 | Nov 13, 2014, 06:21 AM |
| AKBA | President and CEO | Mar 25, 2014 | Buy | $17.00 | 13,850 | 235,450 | 13,850 | Mar 27, 2014, 04:00 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| ZYNE | Director | Jun 14, 2022 | Sale | 54 |
| AKBA | CEO and President | Feb 28, 2022 | Sale | 53,984 |
| AKBA | CEO and President | Mar 01, 2022 | Sale | 117,159 |
| AKBA | CEO and President | Apr 01, 2021 | Sale | 13,971 |
| AKBA | CEO and President | Mar 01, 2021 | Sale | 169,771 |
| AKBA | CEO and President | Nov 20, 2019 | Buy | 172,000 |
| AKBA | CEO and President | Jun 03, 2019 | Option Exercise | 134,890 |
| AKBA | CEO & President | Dec 12, 2018 | Option Exercise | 1,213,131 |
| ZYNE | Director | Aug 22, 2018 | Buy | 32,153 |
| AKBA | CEO and President | Jul 11, 2018 | Option Exercise | 47,000 |
| AKBA | CEO and President | Jan 19, 2017 | Option Exercise | 9,400 |
| RLYP | Director | Sep 01, 2016 | Option Exercise | 72,000 |
| RLYP | Director | Sep 01, 2016 | Option Exercise | 91,168 |
| RLYP | Director | Jun 07, 2016 | Sale | 19,570 |
| AKBA | CEO and President | Jan 15, 2016 | Option Exercise | 11,750 |
| RLYP | Director | Jun 11, 2015 | Sale | 38,087 |
| AKBA | CEO and President | May 26, 2015 | Option Exercise | 23,500 |
| AKBA | CEO and President | Mar 09, 2015 | Option Exercise | 47,000 |
| AKBA | CEO and President | Dec 29, 2014 | Buy | 11,567 |
| AKBA | CEO and President | Dec 22, 2014 | Buy | 11,916 |
| AKBA | CEO and President | Dec 15, 2014 | Buy | 11,336 |
| AKBA | CEO and President | Nov 11, 2014 | Option Exercise | 14,335 |
| AKBA | CEO and President | Nov 12, 2014 | Buy | 10,305 |
| AKBA | President and CEO | Mar 25, 2014 | Buy | 235,450 |