| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| IOBT | 10% Owner | Nov 09, 2021 | Buy | $14.00 | 2,142,857 | 29,999,998 | 6,049,452 | Nov 12, 2021, 04:15 PM |
| IMRA | 10% Owner | Mar 16, 2020 | Buy | $16.00 | 187,500 | 3,000,000 | 1,432,722 | Mar 16, 2020, 05:07 PM |
| TRVI | 10% Owner | May 09, 2019 | Buy | $10.00 | 375,000 | 3,750,000 | 1,151,544 | May 13, 2019, 05:00 PM |
| SCPH | 10% Owner | Nov 21, 2017 | Buy | $14.00 | 654,762 | 9,166,668 | 3,183,986 | Nov 21, 2017, 07:24 PM |
| CLDN | 10% Owner | Feb 04, 2014 | Option Exercise | $8.00 | 18,605 | 148,840 | 1,563,002 | Feb 06, 2014, 03:47 PM |
| CLDN | 10% Owner | Feb 04, 2014 | Buy | $8.00 | 182,681 | 1,461,448 | 1,745,683 | Feb 06, 2014, 03:47 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| IOBT | 10% Owner | Nov 09, 2021 | Buy | 29,999,998 |
| IMRA | 10% Owner | Mar 16, 2020 | Buy | 3,000,000 |
| TRVI | 10% Owner | May 09, 2019 | Buy | 3,750,000 |
| SCPH | 10% Owner | Nov 21, 2017 | Buy | 9,166,668 |
| CLDN | 10% Owner | Feb 04, 2014 | Option Exercise | 148,840 |
| CLDN | 10% Owner | Feb 04, 2014 | Buy | 1,461,448 |