| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| CLDN | VP, Clinical Operations | Jan 09, 2015 | Option Exercise | $1.12 | 10,000 | 11,200 | 11,024 | Jan 12, 2015, 06:28 PM |
| CLDN | VP, Clinical Operations | Jan 09, 2015 | Sale | $18.51 | 10,000 | 185,100 | 1,024 | Jan 12, 2015, 06:28 PM |
| CLDN | VP, Clinical Operations | Dec 09, 2014 | Option Exercise | $1.12 | 10,000 | 11,200 | 10,414 | Dec 10, 2014, 06:43 PM |
| CLDN | VP, Clinical Operations | Dec 09, 2014 | Sale | $15.00 | 10,000 | 150,000 | 414 | Dec 10, 2014, 06:43 PM |
| CLDN | VP, Clinical Operations | Nov 14, 2014 | Option Exercise | $1.12 | 18,000 | 20,160 | 18,000 | Nov 18, 2014, 04:05 PM |
| CLDN | VP, Clinical Operations | Nov 14, 2014 | Sale | $11.67 | 18,000 | 210,060 | 0 | Nov 18, 2014, 04:05 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| CLDN | VP, Clinical Operations | Jan 09, 2015 | Option Exercise | 11,200 |
| CLDN | VP, Clinical Operations | Jan 09, 2015 | Sale | 185,100 |
| CLDN | VP, Clinical Operations | Dec 09, 2014 | Option Exercise | 11,200 |
| CLDN | VP, Clinical Operations | Dec 09, 2014 | Sale | 150,000 |
| CLDN | VP, Clinical Operations | Nov 14, 2014 | Option Exercise | 20,160 |
| CLDN | VP, Clinical Operations | Nov 14, 2014 | Sale | 210,060 |