| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| SCPH | 10% Owner | Apr 11, 2022 | Sale | $5.00 | 9,171 | 45,855 | 120,966 | Apr 13, 2022, 04:51 PM |
| SCPH | 10% Owner | Apr 11, 2022 | Sale | $5.00 | 220,096 | 1,100,480 | 2,903,207 | Apr 13, 2022, 04:51 PM |
| SCPH | 10% Owner | Apr 11, 2022 | Sale | $5.00 | 40,733 | 203,665 | 537,301 | Apr 13, 2022, 04:51 PM |
| FIXX | 10% Owner | Dec 22, 2020 | Sale | $12.82 | 500,000 | 6,410,000 | 4,354,484 | Dec 28, 2020, 09:35 PM |
| FIXX | 10% Owner | Dec 14, 2020 | Sale | $12.25 | 500,000 | 6,125,915 | 5,163,346 | Dec 16, 2020, 07:15 PM |
| IDYA | 10% Owner | Nov 11, 2020 | Sale | $13.66 | 800,000 | 10,928,000 | 2,187,428 | Nov 13, 2020, 08:53 PM |
| APRE | Former 10% holder | Oct 05, 2020 | Sale | $25.30 | 175,000 | 4,427,500 | 138,497 | Oct 07, 2020, 09:30 PM |
| APRE | 10% Owner | Jun 16, 2020 | Sale | $33.30 | 140,000 | 4,662,000 | 1,823,192 | Jun 18, 2020, 07:22 PM |
| APRE | 10% Owner | Jun 11, 2020 | Sale | $28.75 | 245,000 | 7,044,412 | 1,938,549 | Jun 15, 2020, 09:12 PM |
| APRE | 10% Owner | May 19, 2020 | Sale | $35.15 | 255,000 | 8,963,250 | 2,173,748 | May 21, 2020, 09:31 PM |
| APRE | 10% Owner | Oct 07, 2019 | Buy | $15.00 | 333,333 | 4,999,995 | 333,333 | Oct 09, 2019, 06:23 PM |
| CRNX | Former 10% holder | Jun 21, 2019 | Sale | $22.20 | 250,000 | 5,550,000 | 2,267,797 | Jun 25, 2019, 07:03 PM |
| IDYA | 10% Owner | May 28, 2019 | Buy | $10.00 | 750,000 | 7,500,000 | 2,844,545 | May 28, 2019, 08:40 PM |
| FIXX | 10% Owner | May 16, 2019 | Sale | $21.47 | 615,000 | 13,204,050 | 5,314,484 | May 20, 2019, 04:26 PM |
| CRNX | 10% Owner | Mar 18, 2019 | Sale | $24.25 | 154,839 | 3,754,954 | 2,507,797 | Mar 20, 2019, 04:48 PM |
| CRNX | 10% Owner | Jan 22, 2019 | Sale | $21.88 | 262,153 | 5,734,597 | 3,107,642 | Jan 24, 2019, 07:01 PM |
| FIXX | 10% Owner | Dec 10, 2018 | Sale | $26.01 | 15,575 | 405,029 | 5,904,884 | Dec 12, 2018, 08:10 PM |
| FIXX | 10% Owner | Nov 23, 2018 | Sale | $20.04 | 29,682 | 594,709 | 5,919,836 | Nov 27, 2018, 06:08 PM |
| FIXX | 10% Owner | Nov 16, 2018 | Sale | $20.20 | 525,900 | 10,623,180 | 5,948,331 | Nov 20, 2018, 05:05 PM |
| CRNX | 10% Owner | Jul 20, 2018 | Buy | $17.00 | 115,000 | 1,955,000 | 3,359,309 | Jul 20, 2018, 07:02 PM |
| SCPH | 10% Owner | Nov 21, 2017 | Buy | $14.00 | 26,190 | 366,660 | 130,135 | Nov 21, 2017, 07:16 PM |
| SCPH | 10% Owner | Nov 21, 2017 | Buy | $14.00 | 628,572 | 8,800,008 | 3,123,302 | Nov 21, 2017, 07:16 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| SCPH | 10% Owner | Apr 11, 2022 | Sale | 45,855 |
| SCPH | 10% Owner | Apr 11, 2022 | Sale | 1,100,480 |
| SCPH | 10% Owner | Apr 11, 2022 | Sale | 203,665 |
| FIXX | 10% Owner | Dec 22, 2020 | Sale | 6,410,000 |
| FIXX | 10% Owner | Dec 14, 2020 | Sale | 6,125,915 |
| IDYA | 10% Owner | Nov 11, 2020 | Sale | 10,928,000 |
| APRE | Former 10% holder | Oct 05, 2020 | Sale | 4,427,500 |
| APRE | 10% Owner | Jun 16, 2020 | Sale | 4,662,000 |
| APRE | 10% Owner | Jun 11, 2020 | Sale | 7,044,412 |
| APRE | 10% Owner | May 19, 2020 | Sale | 8,963,250 |
| APRE | 10% Owner | Oct 07, 2019 | Buy | 4,999,995 |
| CRNX | Former 10% holder | Jun 21, 2019 | Sale | 5,550,000 |
| IDYA | 10% Owner | May 28, 2019 | Buy | 7,500,000 |
| FIXX | 10% Owner | May 16, 2019 | Sale | 13,204,050 |
| CRNX | 10% Owner | Mar 18, 2019 | Sale | 3,754,954 |
| CRNX | 10% Owner | Jan 22, 2019 | Sale | 5,734,597 |
| FIXX | 10% Owner | Dec 10, 2018 | Sale | 405,029 |
| FIXX | 10% Owner | Nov 23, 2018 | Sale | 594,709 |
| FIXX | 10% Owner | Nov 16, 2018 | Sale | 10,623,180 |
| CRNX | 10% Owner | Jul 20, 2018 | Buy | 1,955,000 |
| SCPH | 10% Owner | Nov 21, 2017 | Buy | 366,660 |
| SCPH | 10% Owner | Nov 21, 2017 | Buy | 8,800,008 |