| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| AVTX | Chief Scientific Officer | Dec 10, 2021 | Buy | $1.57 | 4,267 | 6,699 | 85,639 | Dec 14, 2021, 05:15 PM |
| CERC | Chief Scientific Officer | Jun 10, 2021 | Buy | $2.28 | 3,692 | 8,418 | 81,372 | Jun 14, 2021, 05:04 PM |
| CERC | Chief Scientific Officer | Dec 10, 2020 | Buy | $2.28 | 3,599 | 8,199 | 77,680 | Dec 14, 2020, 04:06 PM |
| CERC | Chief Scientific Officer | Jun 10, 2020 | Buy | $2.28 | 1,799 | 4,098 | 74,081 | Jun 11, 2020, 09:02 PM |
| GNMX | Chief Scientific Officer | Dec 05, 2019 | Buy | $0.13 | 2,049,376 | 274,616 | 2,164,150 | Dec 09, 2019, 09:12 PM |
| GTXI | Director | Jan 02, 2019 | Option Exercise | $0.86 | 14,535 | 12,500 | 36,759 | Jan 03, 2019, 04:27 PM |
| GTXI | Director | Oct 01, 2018 | Option Exercise | $1.50 | 8,333 | 12,500 | 22,224 | Oct 02, 2018, 05:02 PM |
| GTXI | Director | Jul 02, 2018 | Option Exercise | $15.47 | 808 | 12,500 | 13,891 | Jul 03, 2018, 11:05 AM |
| GTXI | Director | Apr 02, 2018 | Option Exercise | $17.47 | 716 | 12,509 | 13,083 | Apr 03, 2018, 04:46 PM |
| GTXI | Director | Jan 02, 2018 | Option Exercise | $11.46 | 1,091 | 12,503 | 12,367 | Jan 04, 2018, 12:40 PM |
| GNMX | Chief Scientific Officer | Oct 17, 2017 | Buy | $1.26 | 75,000 | 94,500 | 114,774 | Oct 18, 2017, 04:16 PM |
| GTXI | Director | Oct 02, 2017 | Option Exercise | $7.94 | 1,574 | 12,498 | 11,277 | Oct 04, 2017, 04:06 PM |
| GTXI | Director | Jul 03, 2017 | Option Exercise | $5.26 | 2,376 | 12,498 | 9,702 | Jul 05, 2017, 12:00 AM |
| GTXI | Director | Apr 03, 2017 | Option Exercise | $4.90 | 2,551 | 12,500 | 7,326 | Apr 05, 2017, 04:58 PM |
| GTXI | Director | Jan 03, 2017 | Option Exercise | $5.21 | 2,399 | 12,499 | 4,775 | Jan 04, 2017, 05:03 PM |
| MDGN | Chief Scientific Officer | Oct 06, 2015 | Buy | $6.50 | 15,384 | 99,996 | 39,774 | Oct 08, 2015, 04:46 PM |
| MDGN | Global Head of R&D | Dec 01, 2014 | Buy | $4.10 | 24,390 | 99,999 | 24,390 | Dec 02, 2014, 08:51 AM |
| Symbol | Relationship | Date | Transaction | Value($) |
| AVTX | Chief Scientific Officer | Dec 10, 2021 | Buy | 6,699 |
| CERC | Chief Scientific Officer | Jun 10, 2021 | Buy | 8,418 |
| CERC | Chief Scientific Officer | Dec 10, 2020 | Buy | 8,199 |
| CERC | Chief Scientific Officer | Jun 10, 2020 | Buy | 4,098 |
| GNMX | Chief Scientific Officer | Dec 05, 2019 | Buy | 274,616 |
| GTXI | Director | Jan 02, 2019 | Option Exercise | 12,500 |
| GTXI | Director | Oct 01, 2018 | Option Exercise | 12,500 |
| GTXI | Director | Jul 02, 2018 | Option Exercise | 12,500 |
| GTXI | Director | Apr 02, 2018 | Option Exercise | 12,509 |
| GTXI | Director | Jan 02, 2018 | Option Exercise | 12,503 |
| GNMX | Chief Scientific Officer | Oct 17, 2017 | Buy | 94,500 |
| GTXI | Director | Oct 02, 2017 | Option Exercise | 12,498 |
| GTXI | Director | Jul 03, 2017 | Option Exercise | 12,498 |
| GTXI | Director | Apr 03, 2017 | Option Exercise | 12,500 |
| GTXI | Director | Jan 03, 2017 | Option Exercise | 12,499 |
| MDGN | Chief Scientific Officer | Oct 06, 2015 | Buy | 99,996 |
| MDGN | Global Head of R&D | Dec 01, 2014 | Buy | 99,999 |