| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 | |
| Y! | IRWD | Director | Feb 26, 2021 | Buy | $8.90 | 3,000 | 26,700 | 218,954 | Mar 02, 2021, 04:41 PM |
| Y! | IRWD | Director | Feb 24, 2021 | Buy | $9.26 | 7,000 | 64,820 | 210,954 | Feb 26, 2021, 05:15 PM |
| Y! | IRWD | Director | Feb 25, 2021 | Buy | $9.11 | 5,000 | 45,550 | 215,954 | Feb 26, 2021, 05:15 PM |
| Y! | IRWD | Director | Feb 24, 2016 | Buy | $8.32 | 10,000 | 83,200 | 144,006 | Feb 26, 2016, 04:34 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| IRWD | Director | Feb 26, 2021 | Buy | 26,700 |
| IRWD | Director | Feb 24, 2021 | Buy | 64,820 |
| IRWD | Director | Feb 25, 2021 | Buy | 45,550 |
| IRWD | Director | Feb 24, 2016 | Buy | 83,200 |