| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| ITOS | 10% Owner | Jan 05, 2022 | Sale | $42.03 | 18,135 | 762,214 | 2,738,785 | Jan 06, 2022, 04:12 PM |
| ITOS | 10% Owner | Jan 04, 2022 | Sale | $42.66 | 128,550 | 5,483,836 | 2,790,725 | Jan 06, 2022, 04:12 PM |
| ITOS | 10% Owner | Dec 07, 2021 | Sale | $33.22 | 19,456 | 646,401 | 2,886,964 | Dec 07, 2021, 06:35 PM |
| ITOS | 10% Owner | Dec 06, 2021 | Sale | $32.59 | 10,208 | 332,698 | 2,906,665 | Dec 07, 2021, 06:35 PM |
| ITOS | 10% Owner | Dec 03, 2021 | Sale | $34.79 | 20,167 | 701,513 | 2,917,732 | Dec 07, 2021, 06:35 PM |
| ITOS | 10% Owner | Dec 01, 2021 | Sale | $34.28 | 12,395 | 424,872 | 2,978,841 | Dec 02, 2021, 06:53 PM |
| ITOS | 10% Owner | Nov 30, 2021 | Sale | $35.09 | 33,937 | 1,190,902 | 3,012,959 | Dec 02, 2021, 06:53 PM |
| ITOS | 10% Owner | Dec 02, 2021 | Sale | $34.83 | 7,430 | 258,787 | 2,935,301 | Dec 02, 2021, 06:53 PM |
| ITOS | 10% Owner | Dec 02, 2021 | Sale | $33.74 | 29,757 | 1,004,001 | 2,942,731 | Dec 02, 2021, 06:53 PM |
| ITOS | 10% Owner | Nov 29, 2021 | Sale | $34.49 | 10,371 | 357,656 | 3,019,118 | Nov 30, 2021, 04:53 PM |
| ITOS | 10% Owner | Nov 26, 2021 | Sale | $35.75 | 12,674 | 453,110 | 3,035,320 | Nov 30, 2021, 04:53 PM |
| ITOS | 10% Owner | Nov 22, 2021 | Sale | $37.52 | 21,114 | 792,271 | 3,110,013 | Nov 24, 2021, 06:34 PM |
| ITOS | 10% Owner | Nov 24, 2021 | Sale | $36.29 | 36,337 | 1,318,543 | 3,073,334 | Nov 24, 2021, 06:34 PM |
| ITOS | 10% Owner | Nov 23, 2021 | Sale | $36.22 | 20,004 | 724,449 | 3,078,561 | Nov 24, 2021, 06:34 PM |
| TRDA | Director | Nov 02, 2021 | Buy | $20.00 | 100,000 | 2,000,000 | 4,425,784 | Nov 04, 2021, 05:36 PM |
| ITOS | 10% Owner | Oct 18, 2021 | Sale | $27.14 | 6,167 | 167,372 | 3,134,991 | Oct 18, 2021, 04:34 PM |
| ITOS | 10% Owner | Oct 15, 2021 | Sale | $27.62 | 10,932 | 301,937 | 3,143,197 | Oct 18, 2021, 04:34 PM |
| ITOS | 10% Owner | Oct 13, 2021 | Sale | $27.13 | 20,929 | 567,804 | 3,179,410 | Oct 14, 2021, 05:27 PM |
| ITOS | 10% Owner | Oct 12, 2021 | Sale | $27.09 | 8,521 | 230,834 | 3,200,339 | Oct 14, 2021, 05:27 PM |
| ITOS | 10% Owner | Oct 14, 2021 | Sale | $27.30 | 27,320 | 745,836 | 3,152,090 | Oct 14, 2021, 05:27 PM |
| ITOS | 10% Owner | Oct 11, 2021 | Sale | $27.24 | 48,812 | 1,329,639 | 3,208,860 | Oct 12, 2021, 04:34 PM |
| ITOS | 10% Owner | Oct 08, 2021 | Sale | $27.01 | 2,032 | 54,884 | 3,257,672 | Oct 12, 2021, 04:34 PM |
| ITOS | 10% Owner | Oct 07, 2021 | Sale | $27.00 | 1,149 | 31,023 | 3,259,704 | Oct 12, 2021, 04:34 PM |
| ITOS | 10% Owner | Oct 04, 2021 | Sale | $27.06 | 20,711 | 560,440 | 3,260,853 | Oct 05, 2021, 04:32 PM |
| ITOS | 10% Owner | Oct 01, 2021 | Sale | $27.00 | 6,855 | 185,085 | 3,281,564 | Oct 05, 2021, 04:32 PM |
| ITOS | 10% Owner | Sep 30, 2021 | Sale | $27.00 | 2,292 | 61,884 | 3,288,419 | Sep 30, 2021, 05:06 PM |
| ITOS | 10% Owner | Sep 28, 2021 | Sale | $27.00 | 19,214 | 518,778 | 3,290,711 | Sep 30, 2021, 05:06 PM |
| ITOS | 10% Owner | Sep 23, 2021 | Sale | $27.97 | 36,930 | 1,032,864 | 3,327,180 | Sep 27, 2021, 05:51 PM |
| ITOS | 10% Owner | Sep 27, 2021 | Sale | $27.09 | 11,625 | 314,921 | 3,309,925 | Sep 27, 2021, 05:51 PM |
| ITOS | 10% Owner | Sep 24, 2021 | Sale | $27.81 | 4,913 | 136,631 | 3,321,550 | Sep 27, 2021, 05:51 PM |
| ITOS | 10% Owner | Sep 22, 2021 | Sale | $27.54 | 14,294 | 393,657 | 3,363,393 | Sep 23, 2021, 04:19 PM |
| ITOS | 10% Owner | Sep 21, 2021 | Sale | $27.47 | 19,635 | 539,373 | 3,377,687 | Sep 23, 2021, 04:19 PM |
| ITOS | 10% Owner | Sep 16, 2021 | Sale | $28.47 | 21,253 | 605,073 | 3,467,323 | Sep 20, 2021, 06:38 PM |
| ITOS | 10% Owner | Sep 20, 2021 | Sale | $27.49 | 24,303 | 668,008 | 3,411,023 | Sep 20, 2021, 06:38 PM |
| ITOS | 10% Owner | Sep 17, 2021 | Sale | $28.82 | 45,698 | 1,317,016 | 3,421,625 | Sep 20, 2021, 06:38 PM |
| ITOS | 10% Owner | Sep 15, 2021 | Sale | $27.80 | 24,104 | 670,207 | 3,489,567 | Sep 16, 2021, 04:48 PM |
| ITOS | 10% Owner | Sep 14, 2021 | Sale | $27.58 | 21,561 | 594,703 | 3,516,303 | Sep 16, 2021, 04:48 PM |
| ITOS | 10% Owner | Sep 09, 2021 | Sale | $28.97 | 22,725 | 658,343 | 3,569,156 | Sep 13, 2021, 07:01 PM |
| ITOS | 10% Owner | Sep 13, 2021 | Sale | $27.64 | 21,384 | 591,054 | 3,534,241 | Sep 13, 2021, 07:01 PM |
| ITOS | 10% Owner | Sep 10, 2021 | Sale | $28.30 | 13,531 | 382,864 | 3,562,396 | Sep 13, 2021, 07:01 PM |
| ITOS | 10% Owner | Sep 08, 2021 | Sale | $28.65 | 12,092 | 346,413 | 3,592,821 | Sep 08, 2021, 07:13 PM |
| ITOS | 10% Owner | Sep 07, 2021 | Sale | $29.18 | 30,474 | 889,231 | 3,635,313 | Sep 08, 2021, 07:13 PM |
| RPTX | Director | Jul 12, 2021 | Sale | $33.59 | 25,559 | 858,434 | 2,242,949 | Jul 13, 2021, 04:22 PM |
| RPTX | Director | Jul 09, 2021 | Sale | $33.06 | 1,792 | 59,244 | 2,268,195 | Jul 13, 2021, 04:22 PM |
| RPTX | Director | Jun 28, 2021 | Sale | $34.18 | 7,270 | 248,521 | 2,272,367 | Jun 30, 2021, 05:26 PM |
| RPTX | Director | Jun 29, 2021 | Sale | $33.29 | 1,190 | 39,615 | 2,269,987 | Jun 30, 2021, 05:26 PM |
| RPTX | Director | Jun 23, 2021 | Sale | $32.98 | 622 | 20,514 | 2,291,087 | Jun 23, 2021, 05:38 PM |
| RPTX | Director | Jun 22, 2021 | Sale | $33.44 | 1,675 | 56,016 | 2,291,898 | Jun 23, 2021, 05:38 PM |
| RPTX | Director | Jun 21, 2021 | Sale | $34.50 | 16,562 | 571,421 | 2,307,390 | Jun 23, 2021, 05:38 PM |
| RPTX | Director | Jun 08, 2021 | Sale | $33.20 | 11,544 | 383,254 | 2,354,065 | Jun 10, 2021, 04:05 PM |
| RPTX | Director | Jun 09, 2021 | Sale | $34.68 | 15,523 | 538,275 | 2,341,721 | Jun 10, 2021, 04:05 PM |
| RPTX | Director | Jun 07, 2021 | Sale | $32.68 | 10,186 | 332,850 | 2,367,178 | Jun 07, 2021, 06:40 PM |
| RPTX | Director | Jun 04, 2021 | Sale | $30.98 | 5,612 | 173,842 | 2,370,304 | Jun 07, 2021, 06:40 PM |
| RPTX | Director | Jun 03, 2021 | Sale | $31.92 | 9,824 | 313,582 | 2,373,848 | Jun 07, 2021, 06:40 PM |
| RPTX | Director | Jun 01, 2021 | Sale | $32.50 | 6,671 | 216,808 | 2,386,410 | Jun 02, 2021, 05:40 PM |
| RPTX | Director | May 28, 2021 | Sale | $32.67 | 7,377 | 241,007 | 2,393,081 | Jun 02, 2021, 05:40 PM |
| RPTX | Director | Jun 02, 2021 | Sale | $31.86 | 2,738 | 87,227 | 2,383,802 | Jun 02, 2021, 05:40 PM |
| RPTX | Director | May 24, 2021 | Sale | $34.12 | 9,782 | 333,795 | 2,425,666 | May 24, 2021, 08:13 PM |
| RPTX | Director | May 21, 2021 | Sale | $34.80 | 133,359 | 4,640,893 | 2,427,229 | May 24, 2021, 08:13 PM |
| HARP | Former 10% Owner | Apr 13, 2021 | Sale | $19.46 | 1,943 | 37,806 | 3,223,853 | Apr 15, 2021, 08:01 PM |
| HARP | Former 10% Owner | Apr 15, 2021 | Sale | $20.49 | 1,052 | 21,555 | 3,220,844 | Apr 15, 2021, 08:01 PM |
| HARP | Former 10% Owner | Apr 14, 2021 | Sale | $20.77 | 1,671 | 34,714 | 3,223,446 | Apr 15, 2021, 08:01 PM |
| ITOS | 10% Owner | Apr 09, 2021 | Sale | $29.99 | 119 | 3,569 | 3,665,787 | Apr 13, 2021, 04:16 PM |
| HARP | 10% Owner | Apr 12, 2021 | Sale | $21.02 | 2,496 | 52,460 | 3,226,369 | Apr 13, 2021, 04:12 PM |
| HARP | 10% Owner | Apr 09, 2021 | Sale | $23.67 | 10,300 | 243,801 | 3,228,006 | Apr 13, 2021, 04:12 PM |
| ITOS | 10% Owner | Apr 07, 2021 | Sale | $32.55 | 5,783 | 188,254 | 3,703,499 | Apr 09, 2021, 04:10 PM |
| ITOS | 10% Owner | Apr 08, 2021 | Sale | $30.52 | 19,304 | 589,089 | 3,666,153 | Apr 09, 2021, 04:10 PM |
| RYTM | Director | Mar 15, 2021 | Sale | $25.10 | 1,000,000 | 25,100,000 | 909,258 | Mar 16, 2021, 05:13 PM |
| RPTX | Director | Mar 12, 2021 | Sale | $28.18 | 376,412 | 10,607,290 | 2,627,360 | Mar 15, 2021, 05:11 PM |
| HARP | 10% Owner | Feb 10, 2021 | Sale | $20.00 | 183,051 | 3,661,020 | 3,238,306 | Feb 12, 2021, 05:03 PM |
| HARP | 10% Owner | Feb 10, 2021 | Sale | $20.00 | 183,051 | 3,661,020 | 3,238,306 | Feb 12, 2021, 05:03 PM |
| HARP | 10% Owner | Feb 09, 2021 | Sale | $20.25 | 9,400 | 190,350 | 3,421,357 | Feb 09, 2021, 06:14 PM |
| HARP | 10% Owner | Feb 08, 2021 | Sale | $20.04 | 72,128 | 1,445,445 | 3,430,757 | Feb 09, 2021, 06:14 PM |
| HARP | 10% Owner | Feb 05, 2021 | Sale | $20.01 | 10,172 | 203,542 | 3,502,885 | Feb 09, 2021, 06:14 PM |
| HARP | 10% Owner | Feb 04, 2021 | Sale | $20.37 | 29,730 | 605,600 | 3,513,057 | Feb 04, 2021, 07:30 PM |
| HARP | 10% Owner | Feb 03, 2021 | Sale | $20.21 | 41,922 | 847,244 | 3,542,787 | Feb 04, 2021, 07:30 PM |
| HARP | 10% Owner | Feb 02, 2021 | Sale | $20.13 | 48,421 | 974,715 | 3,584,709 | Feb 04, 2021, 07:30 PM |
| HARP | 10% Owner | Jan 27, 2021 | Sale | $20.00 | 706,825 | 14,136,500 | 3,633,130 | Jan 27, 2021, 08:35 PM |
| HARP | 10% Owner | Jan 26, 2021 | Sale | $21.08 | 1,363 | 28,732 | 4,339,955 | Jan 27, 2021, 08:35 PM |
| HARP | 10% Owner | Jan 25, 2021 | Sale | $21.23 | 13,006 | 276,117 | 4,341,318 | Jan 27, 2021, 08:35 PM |
| HARP | 10% Owner | Jan 20, 2021 | Sale | $24.04 | 17,694 | 425,291 | 4,508,731 | Jan 22, 2021, 08:16 PM |
| HARP | 10% Owner | Jan 22, 2021 | Sale | $21.72 | 24,695 | 536,375 | 4,354,324 | Jan 22, 2021, 08:16 PM |
| HARP | 10% Owner | Jan 21, 2021 | Sale | $22.22 | 26,066 | 579,095 | 4,384,106 | Jan 22, 2021, 08:16 PM |
| ONCR | 10% Owner | Oct 06, 2020 | Buy | $15.00 | 173,776 | 2,606,640 | 2,849,453 | Oct 08, 2020, 06:31 PM |
| ITOS | 10% Owner | Jul 28, 2020 | Buy | $19.00 | 160,000 | 3,040,000 | 2,083,887 | Jul 29, 2020, 09:18 PM |
| RYTM | Director | Jun 26, 2020 | Sale | $25.04 | 300 | 7,512 | 1,909,258 | Jun 30, 2020, 04:35 PM |
| RYTM | Director | Jun 24, 2020 | Sale | $25.34 | 97,388 | 2,467,812 | 1,927,505 | Jun 25, 2020, 05:38 PM |
| RYTM | Director | Jun 25, 2020 | Sale | $25.41 | 17,947 | 456,033 | 1,909,558 | Jun 25, 2020, 05:38 PM |
| RPTX | Director | Jun 23, 2020 | Buy | $20.00 | 250,000 | 5,000,000 | 3,003,772 | Jun 25, 2020, 04:32 PM |
| RYTM | Director | Jun 05, 2020 | Sale | $20.00 | 1,896 | 37,920 | 2,024,893 | Jun 05, 2020, 04:16 PM |
| RYTM | Director | Jun 03, 2020 | Sale | $20.27 | 18,245 | 369,826 | 2,026,789 | Jun 03, 2020, 05:08 PM |
| RYTM | Director | Jun 02, 2020 | Sale | $20.23 | 15,578 | 315,143 | 2,045,034 | Jun 03, 2020, 05:08 PM |
| RYTM | Director | Jun 01, 2020 | Sale | $20.08 | 10,535 | 211,543 | 2,060,612 | Jun 03, 2020, 05:08 PM |
| RYTM | Director | May 28, 2020 | Sale | $20.19 | 19,152 | 386,679 | 2,071,147 | May 28, 2020, 06:39 PM |
| RYTM | Director | May 27, 2020 | Sale | $20.13 | 10,148 | 204,279 | 2,090,299 | May 28, 2020, 06:39 PM |
| RYTM | Director | May 26, 2020 | Sale | $20.47 | 44,421 | 909,298 | 2,100,447 | May 26, 2020, 05:14 PM |
| RYTM | Director | May 22, 2020 | Sale | $20.13 | 26,906 | 541,618 | 2,144,868 | May 26, 2020, 05:14 PM |
| RYTM | Director | May 21, 2020 | Sale | $20.25 | 25,594 | 518,279 | 2,171,774 | May 26, 2020, 05:14 PM |
| RYTM | Director | May 20, 2020 | Sale | $20.01 | 10,527 | 210,645 | 2,197,368 | May 20, 2020, 05:48 PM |
| RYTM | Director | May 19, 2020 | Sale | $20.00 | 2,633 | 52,660 | 2,207,895 | May 20, 2020, 05:48 PM |
| RYTM | Director | May 18, 2020 | Sale | $20.00 | 21,349 | 426,980 | 2,210,528 | May 20, 2020, 05:48 PM |
| RYTM | Director | May 13, 2020 | Sale | $20.04 | 1,837 | 36,813 | 2,231,877 | May 15, 2020, 05:59 PM |
| RYTM | Director | May 11, 2020 | Sale | $20.34 | 22,155 | 450,633 | 2,258,056 | May 12, 2020, 05:28 PM |
| RYTM | Director | May 08, 2020 | Sale | $20.05 | 6,633 | 132,992 | 2,280,211 | May 12, 2020, 05:28 PM |
| RYTM | Director | May 12, 2020 | Sale | $20.23 | 24,342 | 492,439 | 2,233,714 | May 12, 2020, 05:28 PM |
| RYTM | Director | May 07, 2020 | Sale | $20.01 | 200 | 4,002 | 2,286,844 | May 07, 2020, 05:02 PM |
| RYTM | Director | May 06, 2020 | Sale | $20.00 | 1,626 | 32,520 | 2,287,044 | May 07, 2020, 05:02 PM |
| RYTM | Director | Apr 29, 2020 | Sale | $20.12 | 20,397 | 410,388 | 2,288,670 | Apr 30, 2020, 04:45 PM |
| RYTM | Director | Apr 28, 2020 | Sale | $20.07 | 15,826 | 317,628 | 2,309,067 | Apr 30, 2020, 04:45 PM |
| RYTM | Director | Apr 01, 2020 | Sale | $15.10 | 15,462 | 233,476 | 2,324,893 | Apr 01, 2020, 04:20 PM |
| RYTM | Director | Mar 31, 2020 | Sale | $15.16 | 19,108 | 289,677 | 2,340,355 | Apr 01, 2020, 04:20 PM |
| RYTM | Director | Mar 26, 2020 | Sale | $15.04 | 2,300 | 34,592 | 2,359,463 | Mar 30, 2020, 04:57 PM |
| RYTM | Director | Mar 20, 2020 | Sale | $15.00 | 1,100 | 16,500 | 2,361,763 | Mar 24, 2020, 04:58 PM |
| RYTM | Director | Mar 18, 2020 | Sale | $15.14 | 12,781 | 193,504 | 2,371,063 | Mar 19, 2020, 05:04 PM |
| RYTM | Director | Mar 17, 2020 | Sale | $15.12 | 9,653 | 145,953 | 2,383,844 | Mar 19, 2020, 05:04 PM |
| RYTM | Director | Mar 19, 2020 | Sale | $15.07 | 8,200 | 123,574 | 2,362,863 | Mar 19, 2020, 05:04 PM |
| RYTM | Director | Dec 12, 2019 | Sale | $25.01 | 3,762 | 94,088 | 2,393,497 | Dec 13, 2019, 04:25 PM |
| RYTM | Director | Dec 11, 2019 | Sale | $25.14 | 13,600 | 341,904 | 2,397,259 | Dec 13, 2019, 04:25 PM |
| RYTM | Director | Dec 09, 2019 | Sale | $25.04 | 22,195 | 555,763 | 2,452,698 | Dec 11, 2019, 04:13 PM |
| RYTM | Director | Dec 10, 2019 | Sale | $25.36 | 41,839 | 1,061,037 | 2,410,859 | Dec 11, 2019, 04:13 PM |
| RYTM | Director | Dec 03, 2019 | Sale | $22.33 | 16,777 | 374,630 | 2,474,893 | Dec 03, 2019, 08:05 PM |
| RYTM | Director | Dec 02, 2019 | Sale | $22.03 | 25,366 | 558,813 | 2,491,670 | Dec 03, 2019, 08:05 PM |
| RYTM | Director | Nov 29, 2019 | Sale | $22.67 | 18,359 | 416,199 | 2,517,036 | Nov 29, 2019, 02:40 PM |
| RYTM | Director | Nov 27, 2019 | Sale | $22.91 | 34,960 | 800,934 | 2,535,395 | Nov 29, 2019, 02:40 PM |
| RYTM | Director | Nov 26, 2019 | Sale | $23.31 | 74,225 | 1,730,185 | 2,570,355 | Nov 29, 2019, 02:40 PM |
| RYTM | Director | Nov 25, 2019 | Sale | $23.16 | 121,343 | 2,810,839 | 2,694,900 | Nov 26, 2019, 04:22 PM |
| RYTM | Director | Nov 22, 2019 | Sale | $21.78 | 102,682 | 2,236,718 | 2,767,094 | Nov 26, 2019, 04:22 PM |
| RYTM | Director | Nov 21, 2019 | Sale | $20.55 | 64,923 | 1,334,141 | 2,874,062 | Nov 22, 2019, 05:30 PM |
| RYTM | Director | Nov 20, 2019 | Sale | $22.02 | 141,365 | 3,112,857 | 2,933,528 | Nov 22, 2019, 05:30 PM |
| TCRR | 10% Owner | Feb 19, 2019 | Buy | $15.00 | 706,666 | 10,599,990 | 4,050,865 | Feb 21, 2019, 06:05 PM |
| HARP | 10% Owner | Feb 12, 2019 | Buy | $14.00 | 250,000 | 3,500,000 | 4,524,425 | Feb 14, 2019, 05:32 PM |
| HARP | 10% Owner | Feb 12, 2019 | Sale | $14.00 | 1,524 | 21,336 | 4,274,425 | Feb 14, 2019, 05:32 PM |
| HARP | 10% Owner | Feb 12, 2019 | Option Exercise | $0.05 | 432,119 | 21,260 | 4,275,949 | Feb 14, 2019, 05:32 PM |
| RYTM | Director | Oct 10, 2017 | Buy | $17.00 | 100,000 | 1,700,000 | 2,696,392 | Oct 11, 2017, 02:24 PM |
| PETX | 10% Owner | Mar 10, 2014 | Sale | $20.02 | 600,000 | 12,012,000 | 2,751,048 | Mar 12, 2014, 06:55 PM |
| PETX | 10% Owner | Mar 07, 2014 | Sale | $19.95 | 12,539 | 250,153 | 0 | Mar 11, 2014, 04:47 PM |
| EPZM | 10% Owner | Feb 10, 2014 | Sale | $29.25 | 466,666 | 13,649,981 | 2,413,819 | Feb 11, 2014, 03:56 PM |
| CLDN | Director | Feb 04, 2014 | Option Exercise | $8.00 | 11,370 | 90,960 | 955,167 | Feb 06, 2014, 04:30 PM |
| CLDN | Director | Feb 04, 2014 | Buy | $8.00 | 111,608 | 892,864 | 1,066,775 | Feb 06, 2014, 04:30 PM |
| CNAT | 10% Owner | Jul 30, 2013 | Option Exercise | $11.00 | 16,716 | 183,876 | 1,026,815 | Aug 01, 2013, 02:19 PM |
| CNAT | 10% Owner | Jul 30, 2013 | Buy | $11.00 | 165,265 | 1,817,915 | 1,192,080 | Aug 01, 2013, 02:19 PM |
| PETX | 10% Owner | Jul 02, 2013 | Buy | $6.00 | 500,000 | 3,000,000 | 4,351,050 | Jul 02, 2013, 05:06 PM |
| PCRX | Former 10% Owner | Mar 11, 2013 | Sale | $27.86 | 500,000 | 13,930,000 | 2,790,479 | Mar 13, 2013, 12:31 PM |
| PCRX | 10% Owner | Nov 21, 2011 | Buy | $6.50 | 461,538 | 2,999,997 | 3,290,479 | Nov 22, 2011, 02:04 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| ITOS | 10% Owner | Jan 05, 2022 | Sale | 762,214 |
| ITOS | 10% Owner | Jan 04, 2022 | Sale | 5,483,836 |
| ITOS | 10% Owner | Dec 07, 2021 | Sale | 646,401 |
| ITOS | 10% Owner | Dec 06, 2021 | Sale | 332,698 |
| ITOS | 10% Owner | Dec 03, 2021 | Sale | 701,513 |
| ITOS | 10% Owner | Dec 01, 2021 | Sale | 424,872 |
| ITOS | 10% Owner | Nov 30, 2021 | Sale | 1,190,902 |
| ITOS | 10% Owner | Dec 02, 2021 | Sale | 258,787 |
| ITOS | 10% Owner | Dec 02, 2021 | Sale | 1,004,001 |
| ITOS | 10% Owner | Nov 29, 2021 | Sale | 357,656 |
| ITOS | 10% Owner | Nov 26, 2021 | Sale | 453,110 |
| ITOS | 10% Owner | Nov 22, 2021 | Sale | 792,271 |
| ITOS | 10% Owner | Nov 24, 2021 | Sale | 1,318,543 |
| ITOS | 10% Owner | Nov 23, 2021 | Sale | 724,449 |
| TRDA | Director | Nov 02, 2021 | Buy | 2,000,000 |
| ITOS | 10% Owner | Oct 18, 2021 | Sale | 167,372 |
| ITOS | 10% Owner | Oct 15, 2021 | Sale | 301,937 |
| ITOS | 10% Owner | Oct 13, 2021 | Sale | 567,804 |
| ITOS | 10% Owner | Oct 12, 2021 | Sale | 230,834 |
| ITOS | 10% Owner | Oct 14, 2021 | Sale | 745,836 |
| ITOS | 10% Owner | Oct 11, 2021 | Sale | 1,329,639 |
| ITOS | 10% Owner | Oct 08, 2021 | Sale | 54,884 |
| ITOS | 10% Owner | Oct 07, 2021 | Sale | 31,023 |
| ITOS | 10% Owner | Oct 04, 2021 | Sale | 560,440 |
| ITOS | 10% Owner | Oct 01, 2021 | Sale | 185,085 |
| ITOS | 10% Owner | Sep 30, 2021 | Sale | 61,884 |
| ITOS | 10% Owner | Sep 28, 2021 | Sale | 518,778 |
| ITOS | 10% Owner | Sep 23, 2021 | Sale | 1,032,864 |
| ITOS | 10% Owner | Sep 27, 2021 | Sale | 314,921 |
| ITOS | 10% Owner | Sep 24, 2021 | Sale | 136,631 |
| ITOS | 10% Owner | Sep 22, 2021 | Sale | 393,657 |
| ITOS | 10% Owner | Sep 21, 2021 | Sale | 539,373 |
| ITOS | 10% Owner | Sep 16, 2021 | Sale | 605,073 |
| ITOS | 10% Owner | Sep 20, 2021 | Sale | 668,008 |
| ITOS | 10% Owner | Sep 17, 2021 | Sale | 1,317,016 |
| ITOS | 10% Owner | Sep 15, 2021 | Sale | 670,207 |
| ITOS | 10% Owner | Sep 14, 2021 | Sale | 594,703 |
| ITOS | 10% Owner | Sep 09, 2021 | Sale | 658,343 |
| ITOS | 10% Owner | Sep 13, 2021 | Sale | 591,054 |
| ITOS | 10% Owner | Sep 10, 2021 | Sale | 382,864 |
| ITOS | 10% Owner | Sep 08, 2021 | Sale | 346,413 |
| ITOS | 10% Owner | Sep 07, 2021 | Sale | 889,231 |
| RPTX | Director | Jul 12, 2021 | Sale | 858,434 |
| RPTX | Director | Jul 09, 2021 | Sale | 59,244 |
| RPTX | Director | Jun 28, 2021 | Sale | 248,521 |
| RPTX | Director | Jun 29, 2021 | Sale | 39,615 |
| RPTX | Director | Jun 23, 2021 | Sale | 20,514 |
| RPTX | Director | Jun 22, 2021 | Sale | 56,016 |
| RPTX | Director | Jun 21, 2021 | Sale | 571,421 |
| RPTX | Director | Jun 08, 2021 | Sale | 383,254 |
| RPTX | Director | Jun 09, 2021 | Sale | 538,275 |
| RPTX | Director | Jun 07, 2021 | Sale | 332,850 |
| RPTX | Director | Jun 04, 2021 | Sale | 173,842 |
| RPTX | Director | Jun 03, 2021 | Sale | 313,582 |
| RPTX | Director | Jun 01, 2021 | Sale | 216,808 |
| RPTX | Director | May 28, 2021 | Sale | 241,007 |
| RPTX | Director | Jun 02, 2021 | Sale | 87,227 |
| RPTX | Director | May 24, 2021 | Sale | 333,795 |
| RPTX | Director | May 21, 2021 | Sale | 4,640,893 |
| HARP | Former 10% Owner | Apr 13, 2021 | Sale | 37,806 |
| HARP | Former 10% Owner | Apr 15, 2021 | Sale | 21,555 |
| HARP | Former 10% Owner | Apr 14, 2021 | Sale | 34,714 |
| ITOS | 10% Owner | Apr 09, 2021 | Sale | 3,569 |
| HARP | 10% Owner | Apr 12, 2021 | Sale | 52,460 |
| HARP | 10% Owner | Apr 09, 2021 | Sale | 243,801 |
| ITOS | 10% Owner | Apr 07, 2021 | Sale | 188,254 |
| ITOS | 10% Owner | Apr 08, 2021 | Sale | 589,089 |
| RYTM | Director | Mar 15, 2021 | Sale | 25,100,000 |
| RPTX | Director | Mar 12, 2021 | Sale | 10,607,290 |
| HARP | 10% Owner | Feb 10, 2021 | Sale | 3,661,020 |
| HARP | 10% Owner | Feb 10, 2021 | Sale | 3,661,020 |
| HARP | 10% Owner | Feb 09, 2021 | Sale | 190,350 |
| HARP | 10% Owner | Feb 08, 2021 | Sale | 1,445,445 |
| HARP | 10% Owner | Feb 05, 2021 | Sale | 203,542 |
| HARP | 10% Owner | Feb 04, 2021 | Sale | 605,600 |
| HARP | 10% Owner | Feb 03, 2021 | Sale | 847,244 |
| HARP | 10% Owner | Feb 02, 2021 | Sale | 974,715 |
| HARP | 10% Owner | Jan 27, 2021 | Sale | 14,136,500 |
| HARP | 10% Owner | Jan 26, 2021 | Sale | 28,732 |
| HARP | 10% Owner | Jan 25, 2021 | Sale | 276,117 |
| HARP | 10% Owner | Jan 20, 2021 | Sale | 425,291 |
| HARP | 10% Owner | Jan 22, 2021 | Sale | 536,375 |
| HARP | 10% Owner | Jan 21, 2021 | Sale | 579,095 |
| ONCR | 10% Owner | Oct 06, 2020 | Buy | 2,606,640 |
| ITOS | 10% Owner | Jul 28, 2020 | Buy | 3,040,000 |
| RYTM | Director | Jun 26, 2020 | Sale | 7,512 |
| RYTM | Director | Jun 24, 2020 | Sale | 2,467,812 |
| RYTM | Director | Jun 25, 2020 | Sale | 456,033 |
| RPTX | Director | Jun 23, 2020 | Buy | 5,000,000 |
| RYTM | Director | Jun 05, 2020 | Sale | 37,920 |
| RYTM | Director | Jun 03, 2020 | Sale | 369,826 |
| RYTM | Director | Jun 02, 2020 | Sale | 315,143 |
| RYTM | Director | Jun 01, 2020 | Sale | 211,543 |
| RYTM | Director | May 28, 2020 | Sale | 386,679 |
| RYTM | Director | May 27, 2020 | Sale | 204,279 |
| RYTM | Director | May 26, 2020 | Sale | 909,298 |
| RYTM | Director | May 22, 2020 | Sale | 541,618 |
| RYTM | Director | May 21, 2020 | Sale | 518,279 |
| RYTM | Director | May 20, 2020 | Sale | 210,645 |
| RYTM | Director | May 19, 2020 | Sale | 52,660 |
| RYTM | Director | May 18, 2020 | Sale | 426,980 |
| RYTM | Director | May 13, 2020 | Sale | 36,813 |
| RYTM | Director | May 11, 2020 | Sale | 450,633 |
| RYTM | Director | May 08, 2020 | Sale | 132,992 |
| RYTM | Director | May 12, 2020 | Sale | 492,439 |
| RYTM | Director | May 07, 2020 | Sale | 4,002 |
| RYTM | Director | May 06, 2020 | Sale | 32,520 |
| RYTM | Director | Apr 29, 2020 | Sale | 410,388 |
| RYTM | Director | Apr 28, 2020 | Sale | 317,628 |
| RYTM | Director | Apr 01, 2020 | Sale | 233,476 |
| RYTM | Director | Mar 31, 2020 | Sale | 289,677 |
| RYTM | Director | Mar 26, 2020 | Sale | 34,592 |
| RYTM | Director | Mar 20, 2020 | Sale | 16,500 |
| RYTM | Director | Mar 18, 2020 | Sale | 193,504 |
| RYTM | Director | Mar 17, 2020 | Sale | 145,953 |
| RYTM | Director | Mar 19, 2020 | Sale | 123,574 |
| RYTM | Director | Dec 12, 2019 | Sale | 94,088 |
| RYTM | Director | Dec 11, 2019 | Sale | 341,904 |
| RYTM | Director | Dec 09, 2019 | Sale | 555,763 |
| RYTM | Director | Dec 10, 2019 | Sale | 1,061,037 |
| RYTM | Director | Dec 03, 2019 | Sale | 374,630 |
| RYTM | Director | Dec 02, 2019 | Sale | 558,813 |
| RYTM | Director | Nov 29, 2019 | Sale | 416,199 |
| RYTM | Director | Nov 27, 2019 | Sale | 800,934 |
| RYTM | Director | Nov 26, 2019 | Sale | 1,730,185 |
| RYTM | Director | Nov 25, 2019 | Sale | 2,810,839 |
| RYTM | Director | Nov 22, 2019 | Sale | 2,236,718 |
| RYTM | Director | Nov 21, 2019 | Sale | 1,334,141 |
| RYTM | Director | Nov 20, 2019 | Sale | 3,112,857 |
| TCRR | 10% Owner | Feb 19, 2019 | Buy | 10,599,990 |
| HARP | 10% Owner | Feb 12, 2019 | Buy | 3,500,000 |
| HARP | 10% Owner | Feb 12, 2019 | Sale | 21,336 |
| HARP | 10% Owner | Feb 12, 2019 | Option Exercise | 21,260 |
| RYTM | Director | Oct 10, 2017 | Buy | 1,700,000 |
| PETX | 10% Owner | Mar 10, 2014 | Sale | 12,012,000 |
| PETX | 10% Owner | Mar 07, 2014 | Sale | 250,153 |
| EPZM | 10% Owner | Feb 10, 2014 | Sale | 13,649,981 |
| CLDN | Director | Feb 04, 2014 | Option Exercise | 90,960 |
| CLDN | Director | Feb 04, 2014 | Buy | 892,864 |
| CNAT | 10% Owner | Jul 30, 2013 | Option Exercise | 183,876 |
| CNAT | 10% Owner | Jul 30, 2013 | Buy | 1,817,915 |
| PETX | 10% Owner | Jul 02, 2013 | Buy | 3,000,000 |
| PCRX | Former 10% Owner | Mar 11, 2013 | Sale | 13,930,000 |
| PCRX | 10% Owner | Nov 21, 2011 | Buy | 2,999,997 |