| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| HRC | Chief Human Resources Officer | Nov 09, 2020 | Option Exercise | $95.75 | 1,366 | 130,795 | 38,621 | Nov 10, 2020, 06:10 PM |
| HRC | Chief Human Resources Officer | Nov 09, 2020 | Option Exercise | $95.75 | 4,658 | 446,004 | 38,870 | Nov 10, 2020, 06:10 PM |
| HRC | Chief Human Resources Officer | Nov 03, 2020 | Option Exercise | $91.54 | 1,070 | 97,948 | 35,329 | Nov 05, 2020, 04:05 PM |
| HRC | Chief Human Resources Officer | Nov 03, 2020 | Option Exercise | $91.54 | 3,651 | 334,213 | 36,399 | Nov 05, 2020, 04:05 PM |
| SYNH | Director | May 27, 2020 | Option Exercise | $62.43 | 2,803 | 174,991 | 14,944 | May 29, 2020, 05:04 PM |
| HRC | Chief Human Resources Officer | Nov 15, 2019 | Option Exercise | $104.43 | 1,533 | 160,091 | 32,748 | Nov 18, 2019, 04:08 PM |
| HRC | Chief Human Resources Officer | Nov 15, 2019 | Option Exercise | $104.43 | 3,459 | 361,223 | 34,281 | Nov 18, 2019, 04:08 PM |
| HRC | Chief Human Resources Officer | Nov 08, 2019 | Option Exercise | $103.73 | 571 | 59,230 | 30,822 | Nov 12, 2019, 04:16 PM |
| HRC | Chief Human Resources Officer | Nov 08, 2019 | Option Exercise | $103.73 | 1,287 | 133,501 | 31,393 | Nov 12, 2019, 04:16 PM |
| HRC | Chief Human Resources Officer | Nov 05, 2019 | Option Exercise | $103.72 | 3,130 | 324,644 | 30,106 | Nov 07, 2019, 06:53 PM |
| HRC | Chief Human Resources Officer | Nov 05, 2019 | Option Exercise | $103.72 | 10,330 | 1,071,428 | 33,236 | Nov 07, 2019, 06:53 PM |
| SYNH | Director | May 24, 2019 | Option Exercise | $42.45 | 4,122 | 174,979 | 12,141 | May 29, 2019, 04:08 PM |
| HRC | Chief Human Resources Officer | Nov 17, 2018 | Option Exercise | $93.18 | 1,621 | 151,045 | 22,906 | Nov 20, 2018, 04:14 PM |
| HRC | Chief Human Resources Officer | Nov 17, 2018 | Option Exercise | $93.18 | 3,659 | 340,946 | 24,527 | Nov 20, 2018, 04:14 PM |
| HRC | Chief Human Resources Officer | Oct 01, 2018 | Option Exercise | $94.26 | 3,554 | 335,000 | 20,868 | Oct 03, 2018, 04:12 PM |
| HRC | Chief Human Resources Officer | Oct 01, 2018 | Option Exercise | $94.26 | 9,204 | 867,569 | 24,411 | Oct 03, 2018, 04:12 PM |
| HRC | Chief Human Resources Officer | Sep 22, 2018 | Option Exercise | $91.36 | 2,146 | 196,059 | 15,207 | Sep 26, 2018, 04:02 PM |
| HRC | Chief Human Resources Officer | Sep 22, 2018 | Option Exercise | $91.36 | 7,323 | 669,029 | 17,341 | Sep 26, 2018, 04:02 PM |
| HRC | Chief Human Resources Officer | Sep 22, 2017 | Option Exercise | $73.43 | 2,343 | 172,046 | 10,018 | Sep 26, 2017, 04:04 PM |
| HRC | Chief Human Resources Officer | Sep 22, 2017 | Option Exercise | $73.43 | 7,253 | 532,588 | 12,361 | Sep 26, 2017, 04:04 PM |
| HRC | Chief Human Resources Officer | Sep 30, 2016 | Option Exercise | $61.58 | 7 | 431 | 5,803 | Oct 04, 2016, 08:41 PM |
| HRC | SVP, Chief HR Officer | Sep 22, 2016 | Option Exercise | $60.41 | 2,300 | 138,943 | 5,789 | Sep 26, 2016, 10:51 AM |
| HSP | SVP, Chief Human Resources Ofr | Sep 03, 2015 | Option Exercise | $90.00 | 224,329 | 20,189,610 | 0 | Sep 03, 2015, 11:44 AM |
| HSP | SVP, Chief Human Resources Ofr | Sep 03, 2015 | Option Exercise | $40.67 | 149,321 | 6,072,525 | 224,329 | Sep 03, 2015, 11:44 AM |
| HSP | SVP, Chief Human Resources Ofr | Feb 27, 2015 | Option Exercise | $87.54 | 1,403 | 122,819 | 50,671 | Mar 03, 2015, 05:34 PM |
| HSP | SVP, Chief Human Resources Ofr | Feb 25, 2015 | Option Exercise | $87.50 | 17,296 | 1,513,400 | 45,989 | Feb 27, 2015, 04:24 PM |
| HSP | SVP, Chief Human Resources Ofr | Feb 25, 2015 | Option Exercise | $87.49 | 3,089 | 270,257 | 52,803 | Feb 27, 2015, 04:24 PM |
| HSP | SVP, Chief Human Resources Ofr | Feb 26, 2015 | Option Exercise | $87.54 | 729 | 63,817 | 52,074 | Feb 27, 2015, 04:24 PM |
| HSP | SVP, Chief Human Resources Ofr | Nov 24, 2014 | Option Exercise | $22.15 | 46,250 | 1,024,437 | 59,543 | Nov 25, 2014, 05:10 PM |
| HSP | SVP, Chief Human Resources Ofr | Nov 24, 2014 | Sale | $59.66 | 46,250 | 2,759,267 | 28,693 | Nov 25, 2014, 05:10 PM |
| HSP | SVP, Chief Human Resources Ofr | Feb 26, 2014 | Option Exercise | $43.09 | 1,013 | 43,650 | 22,448 | Feb 28, 2014, 09:38 PM |
| HSP | SVP, Org. Transformation | Aug 16, 2013 | Option Exercise | $40.20 | 1,618 | 65,044 | 21,843 | Aug 20, 2013, 11:43 AM |
| HSP | SVP, Org. Transformation | Dec 31, 2011 | Option Exercise | $30.37 | 2,132 | 64,749 | 9,747 | Jan 03, 2012, 04:27 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| HRC | Chief Human Resources Officer | Nov 09, 2020 | Option Exercise | 130,795 |
| HRC | Chief Human Resources Officer | Nov 09, 2020 | Option Exercise | 446,004 |
| HRC | Chief Human Resources Officer | Nov 03, 2020 | Option Exercise | 97,948 |
| HRC | Chief Human Resources Officer | Nov 03, 2020 | Option Exercise | 334,213 |
| SYNH | Director | May 27, 2020 | Option Exercise | 174,991 |
| HRC | Chief Human Resources Officer | Nov 15, 2019 | Option Exercise | 160,091 |
| HRC | Chief Human Resources Officer | Nov 15, 2019 | Option Exercise | 361,223 |
| HRC | Chief Human Resources Officer | Nov 08, 2019 | Option Exercise | 59,230 |
| HRC | Chief Human Resources Officer | Nov 08, 2019 | Option Exercise | 133,501 |
| HRC | Chief Human Resources Officer | Nov 05, 2019 | Option Exercise | 324,644 |
| HRC | Chief Human Resources Officer | Nov 05, 2019 | Option Exercise | 1,071,428 |
| SYNH | Director | May 24, 2019 | Option Exercise | 174,979 |
| HRC | Chief Human Resources Officer | Nov 17, 2018 | Option Exercise | 151,045 |
| HRC | Chief Human Resources Officer | Nov 17, 2018 | Option Exercise | 340,946 |
| HRC | Chief Human Resources Officer | Oct 01, 2018 | Option Exercise | 335,000 |
| HRC | Chief Human Resources Officer | Oct 01, 2018 | Option Exercise | 867,569 |
| HRC | Chief Human Resources Officer | Sep 22, 2018 | Option Exercise | 196,059 |
| HRC | Chief Human Resources Officer | Sep 22, 2018 | Option Exercise | 669,029 |
| HRC | Chief Human Resources Officer | Sep 22, 2017 | Option Exercise | 172,046 |
| HRC | Chief Human Resources Officer | Sep 22, 2017 | Option Exercise | 532,588 |
| HRC | Chief Human Resources Officer | Sep 30, 2016 | Option Exercise | 431 |
| HRC | SVP, Chief HR Officer | Sep 22, 2016 | Option Exercise | 138,943 |
| HSP | SVP, Chief Human Resources Ofr | Sep 03, 2015 | Option Exercise | 20,189,610 |
| HSP | SVP, Chief Human Resources Ofr | Sep 03, 2015 | Option Exercise | 6,072,525 |
| HSP | SVP, Chief Human Resources Ofr | Feb 27, 2015 | Option Exercise | 122,819 |
| HSP | SVP, Chief Human Resources Ofr | Feb 25, 2015 | Option Exercise | 1,513,400 |
| HSP | SVP, Chief Human Resources Ofr | Feb 25, 2015 | Option Exercise | 270,257 |
| HSP | SVP, Chief Human Resources Ofr | Feb 26, 2015 | Option Exercise | 63,817 |
| HSP | SVP, Chief Human Resources Ofr | Nov 24, 2014 | Option Exercise | 1,024,437 |
| HSP | SVP, Chief Human Resources Ofr | Nov 24, 2014 | Sale | 2,759,267 |
| HSP | SVP, Chief Human Resources Ofr | Feb 26, 2014 | Option Exercise | 43,650 |
| HSP | SVP, Org. Transformation | Aug 16, 2013 | Option Exercise | 65,044 |
| HSP | SVP, Org. Transformation | Dec 31, 2011 | Option Exercise | 64,749 |