| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| BRZE | 10% Owner | Nov 19, 2021 | Sale | $61.42 | 1,130,000 | 69,404,598 | 0 | Nov 23, 2021, 05:00 PM |
| DOCS | 10% Owner | Jun 28, 2021 | Sale | $24.57 | 4,289,250 | 105,386,871 | 0 | Jun 28, 2021, 06:18 PM |
| PMVP | 10% Owner | Sep 25, 2020 | Buy | $18.00 | 55,555 | 999,990 | 55,555 | Oct 02, 2020, 06:41 PM |
| PMVP | 10% Owner | Sep 25, 2020 | Buy | $18.00 | 55,000 | 990,000 | 55,000 | Sep 29, 2020, 04:35 PM |
| OBLN | 10% Owner | Aug 06, 2019 | Buy | $4.00 | 25,000 | 100,000 | 380,224 | Aug 08, 2019, 11:10 AM |
| EIGR | 10% Owner | Oct 18, 2018 | Sale | $12.06 | 237,265 | 2,862,321 | 1,388,792 | Oct 22, 2018, 04:33 PM |
| OBLN | 10% Owner | Aug 23, 2018 | Buy | $1.82 | 1,098,901 | 2,000,000 | 3,552,239 | Aug 27, 2018, 04:24 PM |
| TSRO | 10% Owner | Jul 03, 2012 | Buy | $13.50 | 444,444 | 5,999,994 | 3,071,701 | Jul 05, 2012, 08:18 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| BRZE | 10% Owner | Nov 19, 2021 | Sale | 69,404,598 |
| DOCS | 10% Owner | Jun 28, 2021 | Sale | 105,386,871 |
| PMVP | 10% Owner | Sep 25, 2020 | Buy | 999,990 |
| PMVP | 10% Owner | Sep 25, 2020 | Buy | 990,000 |
| OBLN | 10% Owner | Aug 06, 2019 | Buy | 100,000 |
| EIGR | 10% Owner | Oct 18, 2018 | Sale | 2,862,321 |
| OBLN | 10% Owner | Aug 23, 2018 | Buy | 2,000,000 |
| TSRO | 10% Owner | Jul 03, 2012 | Buy | 5,999,994 |