| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| ALRN | 10% Owner | Jul 05, 2017 | Buy | $15.00 | 60,000 | 900,000 | 1,016,100 | Jul 06, 2017, 06:16 PM |
| TTPH | 10% Owner | Mar 25, 2013 | Buy | $7.00 | 496,121 | 3,472,847 | 1,468,505 | Mar 27, 2013, 08:14 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| ALRN | 10% Owner | Jul 05, 2017 | Buy | 900,000 |
| TTPH | 10% Owner | Mar 25, 2013 | Buy | 3,472,847 |