| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| CRNX | Director | Jul 13, 2022 | Option Exercise | $1.45 | 5,700 | 8,265 | 18,236 | Jul 15, 2022, 04:30 PM |
| CRNX | Director | Jul 13, 2022 | Sale | $20.96 | 5,700 | 119,455 | 12,536 | Jul 15, 2022, 04:30 PM |
| RARE | Director | Mar 04, 2022 | Option Exercise | $40.37 | 7,500 | 302,775 | 23,195 | Mar 08, 2022, 12:25 PM |
| ATRA | Director | Nov 04, 2021 | Sale | $19.50 | 13,354 | 260,403 | 31,500 | Nov 05, 2021, 04:28 PM |
| CRNX | Director | Nov 01, 2021 | Option Exercise | $1.91 | 8,954 | 17,102 | 21,490 | Nov 03, 2021, 04:55 PM |
| CRNX | Director | Nov 01, 2021 | Sale | $25.50 | 8,954 | 228,327 | 12,536 | Nov 03, 2021, 04:55 PM |
| CRNX | Director | Sep 08, 2021 | Option Exercise | $1.91 | 6,046 | 11,548 | 18,582 | Sep 09, 2021, 05:00 PM |
| CRNX | Director | Sep 08, 2021 | Sale | $25.50 | 6,046 | 154,173 | 12,536 | Sep 09, 2021, 05:00 PM |
| CRNX | Director | Jul 26, 2021 | Option Exercise | $1.91 | 5,000 | 9,550 | 17,536 | Jul 27, 2021, 08:00 PM |
| CRNX | Director | Jul 26, 2021 | Sale | $19.59 | 5,000 | 97,950 | 12,536 | Jul 27, 2021, 08:00 PM |
| CRNX | Director | Jul 19, 2021 | Option Exercise | $1.91 | 5,000 | 9,550 | 17,536 | Jul 20, 2021, 05:00 PM |
| CRNX | Director | Jul 19, 2021 | Sale | $19.50 | 5,000 | 97,500 | 12,536 | Jul 20, 2021, 05:00 PM |
| CRNX | Director | Jul 12, 2021 | Option Exercise | $1.91 | 5,000 | 9,550 | 17,536 | Jul 13, 2021, 05:00 PM |
| CRNX | Director | Jul 12, 2021 | Sale | $20.71 | 5,000 | 103,550 | 12,536 | Jul 13, 2021, 05:00 PM |
| RARE | Director | Jul 06, 2020 | Option Exercise | $21.00 | 6,181 | 129,801 | 19,731 | Jul 08, 2020, 12:30 PM |
| RARE | Director | Jul 06, 2020 | Sale | $90.00 | 6,181 | 556,290 | 13,550 | Jul 08, 2020, 12:30 PM |
| RARE | Director | Jul 01, 2020 | Option Exercise | $21.00 | 5,000 | 105,000 | 18,550 | Jul 06, 2020, 02:21 PM |
| RARE | Director | Jul 01, 2020 | Sale | $85.00 | 5,000 | 425,000 | 13,550 | Jul 06, 2020, 02:21 PM |
| RARE | Director | May 18, 2020 | Sale | $75.00 | 1,875 | 140,625 | 11,000 | May 19, 2020, 07:13 PM |
| RARE | Director | Apr 22, 2020 | Sale | $65.00 | 1,875 | 121,875 | 12,875 | Apr 24, 2020, 01:00 PM |
| DERM | Director | Feb 20, 2020 | Option Exercise | $18.75 | 5,051 | 94,706 | 0 | Feb 24, 2020, 07:32 PM |
| DERM | Director | Dec 24, 2019 | Sale | $15.00 | 3,000 | 45,000 | 5,051 | Dec 26, 2019, 04:13 PM |
| CRNX | Director | Dec 16, 2019 | Option Exercise | $1.91 | 3,500 | 6,685 | 16,036 | Dec 18, 2019, 06:32 PM |
| CRNX | Director | Dec 16, 2019 | Sale | $22.50 | 3,500 | 78,750 | 12,536 | Dec 18, 2019, 06:32 PM |
| DERM | Director | Dec 12, 2019 | Sale | $12.00 | 3,000 | 36,000 | 8,051 | Dec 13, 2019, 05:13 PM |
| DERM | Director | Sep 12, 2019 | Sale | $8.77 | 6,000 | 52,636 | 11,051 | Sep 16, 2019, 04:09 PM |
| MGNX | Director | Feb 06, 2019 | Option Exercise | $20.15 | 6,924 | 139,519 | 7,424 | Feb 08, 2019, 05:41 PM |
| MGNX | Director | Feb 06, 2019 | Sale | $29.38 | 6,924 | 203,427 | 500 | Feb 08, 2019, 05:41 PM |
| DERM | Director | Oct 19, 2018 | Sale | $13.75 | 4,000 | 55,000 | 14,051 | Oct 19, 2018, 04:24 PM |
| RARE | Director | May 30, 2018 | Sale | $72.00 | 6,319 | 454,969 | 8,750 | May 30, 2018, 07:26 PM |
| ATRA | Director | May 14, 2018 | Sale | $43.57 | 12,286 | 535,301 | 19,820 | May 16, 2018, 08:40 PM |
| DERM | Director | Jun 29, 2015 | Option Exercise | $5.51 | 9,051 | 49,871 | 15,051 | Jun 30, 2015, 04:09 PM |
| RARE | Director | Mar 19, 2015 | Option Exercise | $21.00 | 6,319 | 132,699 | 11,319 | Mar 23, 2015, 04:16 PM |
| DERM | Director | Nov 25, 2014 | Buy | $16.77 | 6,000 | 100,604 | 6,000 | Nov 26, 2014, 04:11 PM |
| RARE | Director | Jan 30, 2014 | Buy | $21.00 | 5,000 | 105,000 | 5,000 | Feb 03, 2014, 08:34 PM |
| ONXX | EVP & Chief Financial Officer | Oct 01, 2013 | Option Exercise | $125.00 | 31,150 | 3,893,750 | 0 | Oct 03, 2013, 09:18 PM |
| ONXX | EVP & Chief Financial Officer | Oct 01, 2013 | Option Exercise | $125.00 | 9,153 | 1,144,125 | 31,150 | Oct 03, 2013, 09:18 PM |
| ONXX | EVP & Chief Financial Officer | Aug 08, 2013 | Sale | $128.21 | 2,492 | 319,499 | 40,303 | Aug 12, 2013, 07:11 PM |
| ONXX | EVP & Chief Financial Officer | Jul 26, 2013 | Sale | $130.50 | 6,043 | 788,612 | 42,795 | Jul 29, 2013, 07:45 PM |
| ONXX | EVP & Chief Financial Officer | Jul 02, 2013 | Sale | $132.80 | 1,551 | 205,973 | 48,961 | Jul 05, 2013, 04:03 PM |
| ONXX | EVP & Chief Financial Officer | May 13, 2013 | Option Exercise | $34.48 | 10,269 | 354,075 | 60,473 | May 15, 2013, 06:51 PM |
| ONXX | EVP & Chief Financial Officer | May 13, 2013 | Sale | $98.22 | 10,269 | 1,008,598 | 56,204 | May 15, 2013, 06:51 PM |
| ONXX | EVP & Chief Financial Officer | Apr 15, 2013 | Sale | $95.15 | 1,347 | 128,167 | 50,204 | Apr 16, 2013, 04:23 PM |
| ONXX | EVP & Chief Financial Officer | Apr 01, 2013 | Sale | $86.14 | 3,861 | 332,575 | 54,245 | Apr 03, 2013, 07:51 PM |
| ONXX | EVP & Chief Financial Officer | Mar 05, 2013 | Option Exercise | $34.48 | 2,211 | 76,235 | 47,412 | Mar 05, 2013, 08:14 PM |
| ONXX | EVP & Chief Financial Officer | Feb 28, 2013 | Option Exercise | $34.48 | 10,000 | 344,800 | 60,201 | Mar 04, 2013, 06:39 PM |
| ONXX | EVP & Chief Financial Officer | Feb 28, 2013 | Sale | $77.12 | 15,000 | 1,156,800 | 45,201 | Mar 04, 2013, 06:39 PM |
| ONXX | EVP & Chief Financial Officer | Jan 10, 2013 | Option Exercise | $34.48 | 7,112 | 245,222 | 60,400 | Jan 11, 2013, 08:32 PM |
| ONXX | EVP & Chief Financial Officer | Jan 10, 2013 | Sale | $84.87 | 10,199 | 865,582 | 53,500 | Jan 11, 2013, 08:32 PM |
| ONXX | EVP & Chief Financial Officer | Nov 28, 2012 | Option Exercise | $34.48 | 966 | 33,308 | 53,123 | Nov 30, 2012, 07:23 PM |
| ONXX | Chief Financial Officer | Aug 06, 2012 | Option Exercise | $34.48 | 17,492 | 603,124 | 85,416 | Aug 08, 2012, 09:48 PM |
| ONXX | Chief Financial Officer | Aug 06, 2012 | Sale | $71.71 | 22,009 | 1,578,267 | 70,416 | Aug 08, 2012, 09:48 PM |
| ONXX | Chief Financial Officer | Jul 25, 2012 | Sale | $73.97 | 5,207 | 385,171 | 67,924 | Jul 27, 2012, 08:23 PM |
| ONXX | Chief Financial Officer | Apr 02, 2012 | Option Exercise | $36.58 | 1,577 | 57,682 | 73,630 | Apr 03, 2012, 08:30 PM |
| ONXX | Chief Financial Officer | Mar 02, 2012 | Sale | $37.52 | 592 | 22,212 | 48,237 | Mar 06, 2012, 07:21 PM |
| ONXX | Chief Financial Officer | Feb 14, 2012 | Option Exercise | $34.48 | 5,000 | 172,400 | 48,829 | Feb 16, 2012, 05:54 PM |
| ONXX | Chief Financial Officer | Jan 06, 2012 | Sale | $43.46 | 1,789 | 77,750 | 43,829 | Jan 10, 2012, 05:29 PM |
| ONXX | Chief Financial Officer | Nov 18, 2011 | Sale | $38.05 | 867 | 32,989 | 45,310 | Nov 21, 2011, 05:21 PM |
| ONXX | Chief Financial Officer | Apr 01, 2011 | Sale | $35.02 | 800 | 28,016 | 45,801 | Apr 04, 2011, 08:25 PM |
| ONXX | Chief Financial Officer | Jan 06, 2011 | Sale | $37.28 | 1,812 | 67,551 | 18,101 | Jan 07, 2011, 07:29 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| CRNX | Director | Jul 13, 2022 | Option Exercise | 8,265 |
| CRNX | Director | Jul 13, 2022 | Sale | 119,455 |
| RARE | Director | Mar 04, 2022 | Option Exercise | 302,775 |
| ATRA | Director | Nov 04, 2021 | Sale | 260,403 |
| CRNX | Director | Nov 01, 2021 | Option Exercise | 17,102 |
| CRNX | Director | Nov 01, 2021 | Sale | 228,327 |
| CRNX | Director | Sep 08, 2021 | Option Exercise | 11,548 |
| CRNX | Director | Sep 08, 2021 | Sale | 154,173 |
| CRNX | Director | Jul 26, 2021 | Option Exercise | 9,550 |
| CRNX | Director | Jul 26, 2021 | Sale | 97,950 |
| CRNX | Director | Jul 19, 2021 | Option Exercise | 9,550 |
| CRNX | Director | Jul 19, 2021 | Sale | 97,500 |
| CRNX | Director | Jul 12, 2021 | Option Exercise | 9,550 |
| CRNX | Director | Jul 12, 2021 | Sale | 103,550 |
| RARE | Director | Jul 06, 2020 | Option Exercise | 129,801 |
| RARE | Director | Jul 06, 2020 | Sale | 556,290 |
| RARE | Director | Jul 01, 2020 | Option Exercise | 105,000 |
| RARE | Director | Jul 01, 2020 | Sale | 425,000 |
| RARE | Director | May 18, 2020 | Sale | 140,625 |
| RARE | Director | Apr 22, 2020 | Sale | 121,875 |
| DERM | Director | Feb 20, 2020 | Option Exercise | 94,706 |
| DERM | Director | Dec 24, 2019 | Sale | 45,000 |
| CRNX | Director | Dec 16, 2019 | Option Exercise | 6,685 |
| CRNX | Director | Dec 16, 2019 | Sale | 78,750 |
| DERM | Director | Dec 12, 2019 | Sale | 36,000 |
| DERM | Director | Sep 12, 2019 | Sale | 52,636 |
| MGNX | Director | Feb 06, 2019 | Option Exercise | 139,519 |
| MGNX | Director | Feb 06, 2019 | Sale | 203,427 |
| DERM | Director | Oct 19, 2018 | Sale | 55,000 |
| RARE | Director | May 30, 2018 | Sale | 454,969 |
| ATRA | Director | May 14, 2018 | Sale | 535,301 |
| DERM | Director | Jun 29, 2015 | Option Exercise | 49,871 |
| RARE | Director | Mar 19, 2015 | Option Exercise | 132,699 |
| DERM | Director | Nov 25, 2014 | Buy | 100,604 |
| RARE | Director | Jan 30, 2014 | Buy | 105,000 |
| ONXX | EVP & Chief Financial Officer | Oct 01, 2013 | Option Exercise | 3,893,750 |
| ONXX | EVP & Chief Financial Officer | Oct 01, 2013 | Option Exercise | 1,144,125 |
| ONXX | EVP & Chief Financial Officer | Aug 08, 2013 | Sale | 319,499 |
| ONXX | EVP & Chief Financial Officer | Jul 26, 2013 | Sale | 788,612 |
| ONXX | EVP & Chief Financial Officer | Jul 02, 2013 | Sale | 205,973 |
| ONXX | EVP & Chief Financial Officer | May 13, 2013 | Option Exercise | 354,075 |
| ONXX | EVP & Chief Financial Officer | May 13, 2013 | Sale | 1,008,598 |
| ONXX | EVP & Chief Financial Officer | Apr 15, 2013 | Sale | 128,167 |
| ONXX | EVP & Chief Financial Officer | Apr 01, 2013 | Sale | 332,575 |
| ONXX | EVP & Chief Financial Officer | Mar 05, 2013 | Option Exercise | 76,235 |
| ONXX | EVP & Chief Financial Officer | Feb 28, 2013 | Option Exercise | 344,800 |
| ONXX | EVP & Chief Financial Officer | Feb 28, 2013 | Sale | 1,156,800 |
| ONXX | EVP & Chief Financial Officer | Jan 10, 2013 | Option Exercise | 245,222 |
| ONXX | EVP & Chief Financial Officer | Jan 10, 2013 | Sale | 865,582 |
| ONXX | EVP & Chief Financial Officer | Nov 28, 2012 | Option Exercise | 33,308 |
| ONXX | Chief Financial Officer | Aug 06, 2012 | Option Exercise | 603,124 |
| ONXX | Chief Financial Officer | Aug 06, 2012 | Sale | 1,578,267 |
| ONXX | Chief Financial Officer | Jul 25, 2012 | Sale | 385,171 |
| ONXX | Chief Financial Officer | Apr 02, 2012 | Option Exercise | 57,682 |
| ONXX | Chief Financial Officer | Mar 02, 2012 | Sale | 22,212 |
| ONXX | Chief Financial Officer | Feb 14, 2012 | Option Exercise | 172,400 |
| ONXX | Chief Financial Officer | Jan 06, 2012 | Sale | 77,750 |
| ONXX | Chief Financial Officer | Nov 18, 2011 | Sale | 32,989 |
| ONXX | Chief Financial Officer | Apr 01, 2011 | Sale | 28,016 |
| ONXX | Chief Financial Officer | Jan 06, 2011 | Sale | 67,551 |