| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| CYT | 10% Owner | Jul 20, 2022 | Sale | $3.00 | 900,000 | 2,700,000 | 3,940,413 | Jul 22, 2022, 06:52 PM |
| BOLT | 10% Owner | Jul 13, 2022 | Sale | $2.00 | 800,000 | 1,600,000 | 3,703,991 | Jul 15, 2022, 04:16 PM |
| CMPI | 10% Owner | Feb 25, 2022 | Sale | $2.70 | 300 | 811 | 2,161,990 | Feb 25, 2022, 06:21 PM |
| CMPI | 10% Owner | Feb 24, 2022 | Sale | $2.83 | 5,990 | 16,979 | 2,162,290 | Feb 25, 2022, 06:21 PM |
| CMPI | 10% Owner | Feb 23, 2022 | Sale | $2.90 | 1,820 | 5,277 | 2,168,280 | Feb 25, 2022, 06:21 PM |
| ACLX | 10% Owner | Feb 08, 2022 | Buy | $15.00 | 833,333 | 12,499,995 | 4,016,878 | Feb 09, 2022, 05:42 PM |
| IOBT | 10% Owner | Nov 09, 2021 | Buy | $14.00 | 325,000 | 4,550,000 | 3,277,932 | Nov 10, 2021, 07:04 PM |
| UTRS | 10% Owner | Oct 26, 2021 | Buy | $12.00 | 580,000 | 6,960,000 | 2,057,132 | Oct 27, 2021, 04:31 PM |
| CYT | 10% Owner | Jun 22, 2021 | Buy | $18.00 | 277,777 | 4,999,986 | 4,840,413 | Jun 23, 2021, 05:18 PM |
| SPRB | 10% Owner | May 19, 2021 | Sale | $13.90 | 475,000 | 6,602,500 | 4,514,336 | May 21, 2021, 04:32 PM |
| RPHM | 10% Owner | Apr 13, 2021 | Buy | $15.00 | 666,666 | 9,999,990 | 3,430,377 | Apr 14, 2021, 04:44 PM |
| EWTX | 10% Owner | Mar 30, 2021 | Buy | $16.00 | 625,000 | 10,000,000 | 5,587,207 | Mar 31, 2021, 04:36 PM |
| INGN | 10% Owner | Mar 01, 2021 | Sale | $49.00 | 790,000 | 38,710,000 | 2,759,320 | Mar 03, 2021, 04:33 PM |
| GRTX | 10% Owner | Feb 18, 2021 | Sale | $10.58 | 500,000 | 5,290,000 | 2,459,021 | Feb 19, 2021, 05:20 PM |
| BOLT | 10% Owner | Feb 09, 2021 | Buy | $20.00 | 400,000 | 8,000,000 | 4,503,991 | Feb 11, 2021, 04:39 PM |
| INZY | 10% Owner | Jan 28, 2021 | Sale | $21.00 | 375,000 | 7,875,000 | 2,194,379 | Feb 01, 2021, 04:30 PM |
| GLTO | 10% Owner | Nov 02, 2020 | Buy | $15.00 | 333,333 | 4,999,995 | 2,497,791 | Nov 04, 2020, 07:52 PM |
| EAR | 10% Owner | Oct 20, 2020 | Buy | $18.00 | 150,000 | 2,700,000 | 887,071 | Oct 22, 2020, 04:32 PM |
| ALGS | 10% Owner | Oct 20, 2020 | Buy | $15.00 | 200,000 | 3,000,000 | 2,614,563 | Oct 22, 2020, 04:31 PM |
| GRTX | 10% Owner | Oct 15, 2020 | Sale | $11.00 | 450,000 | 4,950,000 | 2,959,021 | Oct 19, 2020, 04:34 PM |
| SPRB | 10% Owner | Oct 14, 2020 | Buy | $15.00 | 250,000 | 3,750,000 | 4,989,336 | Oct 16, 2020, 04:49 PM |
| HRMY | 10% Owner | Aug 21, 2020 | Buy | $24.00 | 132,503 | 3,180,072 | 4,409,803 | Aug 25, 2020, 04:34 PM |
| CMPI | 10% Owner | Aug 11, 2020 | Buy | $15.00 | 500,000 | 7,500,000 | 2,170,100 | Aug 13, 2020, 04:52 PM |
| INZY | 10% Owner | Jul 28, 2020 | Buy | $16.00 | 375,000 | 6,000,000 | 2,569,379 | Jul 29, 2020, 05:29 PM |
| NKTX | 10% Owner | Jul 14, 2020 | Buy | $18.00 | 555,555 | 9,999,990 | 2,793,865 | Jul 16, 2020, 04:41 PM |
| CRVS | 10% Owner | Jul 08, 2020 | Sale | $5.37 | 741,440 | 3,985,166 | 1,389,498 | Jul 09, 2020, 04:35 PM |
| CRVS | 10% Owner | Jul 07, 2020 | Sale | $5.25 | 796,622 | 4,183,381 | 2,130,938 | Jul 09, 2020, 04:35 PM |
| MIST | 10% Owner | Nov 25, 2019 | Sale | $16.00 | 240,000 | 3,840,000 | 2,434,470 | Nov 27, 2019, 02:39 PM |
| GRTX | 10% Owner | Nov 12, 2019 | Buy | $12.00 | 500,000 | 6,000,000 | 3,409,021 | Nov 14, 2019, 02:16 PM |
| CRVS | 10% Owner | Jul 25, 2019 | Sale | $4.00 | 1,400,000 | 5,600,000 | 2,927,560 | Jul 25, 2019, 07:21 PM |
| CRVS | 10% Owner | Jul 24, 2019 | Sale | $5.01 | 53,240 | 266,711 | 4,327,560 | Jul 25, 2019, 07:21 PM |
| CRVS | 10% Owner | Jul 23, 2019 | Sale | $5.32 | 39,716 | 211,134 | 4,380,800 | Jul 25, 2019, 07:21 PM |
| MIRM | 10% Owner | Jul 22, 2019 | Buy | $15.00 | 575,000 | 8,625,000 | 2,445,147 | Jul 23, 2019, 04:32 PM |
| MORF | 10% Owner | Jun 28, 2019 | Buy | $15.00 | 666,667 | 10,000,005 | 2,645,446 | Jul 01, 2019, 04:31 PM |
| MIST | 10% Owner | May 13, 2019 | Buy | $15.00 | 333,333 | 4,999,995 | 2,674,470 | May 14, 2019, 04:31 PM |
| ETTX | 10% Owner | Sep 28, 2018 | Buy | $15.00 | 1,089,835 | 16,347,525 | 2,181,843 | Oct 01, 2018, 04:36 PM |
| CRVS | 10% Owner | Mar 12, 2018 | Buy | $8.50 | 1,176,470 | 9,999,995 | 4,420,516 | Mar 13, 2018, 05:12 PM |
| KALV | 10% Owner | Oct 11, 2017 | Sale | $10.21 | 35,519 | 362,763 | 1,726,481 | Oct 12, 2017, 05:21 PM |
| KALV | 10% Owner | Oct 10, 2017 | Sale | $11.66 | 963,283 | 11,232,599 | 2,311,927 | Oct 12, 2017, 05:21 PM |
| KALV | 10% Owner | Oct 12, 2017 | Sale | $8.50 | 1,726,481 | 14,675,820 | 1,726,000 | Oct 12, 2017, 05:21 PM |
| KALV | 10% Owner | Sep 15, 2017 | Sale | $7.00 | 140,744 | 985,841 | 2,725,283 | Sep 18, 2017, 07:04 PM |
| KALV | 10% Owner | Sep 14, 2017 | Sale | $8.05 | 10,000 | 80,500 | 2,866,027 | Sep 18, 2017, 07:04 PM |
| KALV | 10% Owner | Sep 13, 2017 | Sale | $8.02 | 25,900 | 207,614 | 2,876,027 | Sep 18, 2017, 07:04 PM |
| KALV | 10% Owner | Sep 14, 2017 | Sale | $8.05 | 10,000 | 80,500 | 2,866,027 | Sep 15, 2017, 07:18 PM |
| KALV | 10% Owner | Sep 13, 2017 | Sale | $8.02 | 25,900 | 207,614 | 2,876,027 | Sep 15, 2017, 07:18 PM |
| KALV | 10% Owner | Sep 15, 2017 | Sale | $7.00 | 140,747 | 985,865 | 2,725,283 | Sep 15, 2017, 07:18 PM |
| HTGM | 10% Owner | Aug 25, 2017 | Sale | $1.75 | 720,214 | 1,260,591 | 0 | Aug 25, 2017, 07:17 PM |
| HTGM | 10% Owner | Aug 24, 2017 | Sale | $1.91 | 382,437 | 729,919 | 720,214 | Aug 25, 2017, 07:17 PM |
| HTGM | 10% Owner | Aug 23, 2017 | Sale | $2.02 | 47,162 | 95,475 | 1,102,651 | Aug 25, 2017, 07:17 PM |
| HTGM | 10% Owner | Aug 22, 2017 | Sale | $2.01 | 12,641 | 25,412 | 1,199,599 | Aug 22, 2017, 07:25 PM |
| HTGM | 10% Owner | Aug 21, 2017 | Sale | $2.02 | 12,845 | 25,976 | 1,212,240 | Aug 22, 2017, 07:25 PM |
| HTGM | 10% Owner | Aug 18, 2017 | Sale | $2.10 | 55,100 | 115,600 | 1,225,085 | Aug 22, 2017, 07:25 PM |
| ANAB | 10% Owner | Aug 21, 2017 | Sale | $21.10 | 356,300 | 7,518,251 | 1,936,604 | Aug 21, 2017, 05:11 PM |
| ANAB | 10% Owner | Aug 14, 2017 | Sale | $21.79 | 35,172 | 766,493 | 2,436,332 | Aug 16, 2017, 04:56 PM |
| ANAB | 10% Owner | Aug 15, 2017 | Sale | $21.00 | 143,428 | 3,011,988 | 2,292,904 | Aug 16, 2017, 04:56 PM |
| ANAB | 10% Owner | Aug 07, 2017 | Sale | $21.10 | 481,023 | 10,151,443 | 2,472,527 | Aug 08, 2017, 06:08 PM |
| ANAB | 10% Owner | Aug 04, 2017 | Sale | $22.00 | 10,271 | 225,963 | 2,952,527 | Aug 08, 2017, 06:08 PM |
| ANAB | 10% Owner | Aug 03, 2017 | Sale | $22.01 | 21,451 | 472,192 | 2,962,798 | Aug 03, 2017, 05:21 PM |
| ANAB | 10% Owner | Aug 02, 2017 | Sale | $23.87 | 25,700 | 613,485 | 2,984,249 | Aug 03, 2017, 05:21 PM |
| ANAB | 10% Owner | Aug 01, 2017 | Sale | $23.87 | 23,555 | 562,270 | 3,009,949 | Aug 03, 2017, 05:21 PM |
| APEN | 10% Owner | Jul 26, 2017 | Sale | $6.84 | 8,426 | 57,643 | 1,301,842 | Jul 26, 2017, 07:22 PM |
| APEN | 10% Owner | Jul 25, 2017 | Sale | $6.96 | 24,504 | 170,585 | 1,310,268 | Jul 26, 2017, 07:22 PM |
| APEN | 10% Owner | Jul 24, 2017 | Sale | $6.83 | 17,200 | 117,538 | 1,334,772 | Jul 26, 2017, 07:22 PM |
| CRVS | 10% Owner | Jun 23, 2017 | Buy | $10.95 | 20,000 | 219,000 | 3,244,046 | Jun 27, 2017, 04:52 PM |
| RETA | 10% Owner | Jun 13, 2017 | Sale | $25.47 | 11,389 | 290,073 | 642,405 | Jun 14, 2017, 04:39 PM |
| RETA | 10% Owner | Jun 14, 2017 | Sale | $25.03 | 49,611 | 1,241,853 | 592,794 | Jun 14, 2017, 04:39 PM |
| RETA | 10% Owner | Jun 12, 2017 | Sale | $25.28 | 90,303 | 2,282,824 | 653,794 | Jun 12, 2017, 06:12 PM |
| RETA | 10% Owner | Jun 09, 2017 | Sale | $25.89 | 2,200 | 56,955 | 744,097 | Jun 12, 2017, 06:12 PM |
| RETA | 10% Owner | Jun 08, 2017 | Sale | $26.00 | 130,000 | 3,380,000 | 746,297 | Jun 12, 2017, 06:12 PM |
| RETA | 10% Owner | Jun 06, 2017 | Sale | $28.09 | 64,170 | 1,802,490 | 878,297 | Jun 07, 2017, 07:01 PM |
| RETA | 10% Owner | Jun 05, 2017 | Sale | $28.67 | 23,327 | 668,825 | 942,467 | Jun 07, 2017, 07:01 PM |
| RETA | 10% Owner | Jun 07, 2017 | Sale | $28.04 | 2,000 | 56,079 | 876,297 | Jun 07, 2017, 07:01 PM |
| APEN | 10% Owner | May 11, 2017 | Sale | $5.62 | 103,500 | 582,094 | 1,351,972 | May 11, 2017, 06:00 PM |
| APEN | 10% Owner | May 10, 2017 | Sale | $5.74 | 1,500 | 8,608 | 1,455,472 | May 11, 2017, 06:00 PM |
| ANAB | 10% Owner | Jan 31, 2017 | Buy | $15.00 | 50,000 | 750,000 | 3,033,504 | Feb 01, 2017, 04:22 PM |
| OPHT | 10% Owner | Dec 14, 2016 | Sale | $4.97 | 2,205,000 | 10,962,378 | 1,405,487 | Dec 16, 2016, 06:29 PM |
| OPHT | 10% Owner | Dec 15, 2016 | Sale | $4.72 | 1,405,487 | 6,636,007 | 0 | Dec 16, 2016, 06:29 PM |
| RARX | 10% Owner | Oct 31, 2016 | Buy | $13.00 | 246,154 | 3,200,002 | 2,031,562 | Nov 02, 2016, 04:54 PM |
| IRTC | 10% Owner | Oct 25, 2016 | Buy | $17.00 | 100,000 | 1,700,000 | 2,124,448 | Oct 26, 2016, 04:46 PM |
| CLCD | 10% Owner | Sep 09, 2016 | Buy | $20.00 | 100,000 | 2,000,000 | 3,156,563 | Sep 13, 2016, 11:48 AM |
| TBRA | 10% Owner | Jul 12, 2016 | Sale | $12.12 | 8,752 | 106,072 | 1,905,789 | Jul 13, 2016, 06:26 PM |
| TBRA | 10% Owner | Jul 11, 2016 | Sale | $12.19 | 20,431 | 249,101 | 1,914,541 | Jul 13, 2016, 06:26 PM |
| TBRA | 10% Owner | Jul 13, 2016 | Sale | $11.88 | 29,884 | 354,944 | 1,875,905 | Jul 13, 2016, 06:26 PM |
| TBRA | 10% Owner | Jul 07, 2016 | Sale | $12.03 | 21,869 | 263,150 | 1,934,972 | Jul 07, 2016, 06:46 PM |
| TBRA | 10% Owner | Jul 06, 2016 | Sale | $12.20 | 59,850 | 730,272 | 1,956,841 | Jul 07, 2016, 06:46 PM |
| TBRA | 10% Owner | Jul 05, 2016 | Sale | $12.57 | 10,400 | 130,709 | 2,016,691 | Jul 07, 2016, 06:46 PM |
| TBRA | 10% Owner | Jun 30, 2016 | Sale | $12.58 | 27,133 | 341,368 | 2,027,091 | Jun 30, 2016, 06:01 PM |
| TBRA | 10% Owner | Jun 29, 2016 | Sale | $12.63 | 16,068 | 202,947 | 2,054,224 | Jun 30, 2016, 06:01 PM |
| TBRA | 10% Owner | Jun 28, 2016 | Sale | $13.83 | 23,613 | 326,626 | 2,073,022 | Jun 30, 2016, 06:01 PM |
| TBRA | 10% Owner | Jun 06, 2016 | Sale | $10.37 | 187,500 | 1,943,906 | 2,093,905 | Jun 07, 2016, 05:08 PM |
| RETA | 10% Owner | Jun 01, 2016 | Buy | $11.00 | 750,000 | 8,250,000 | 750,000 | Jun 02, 2016, 04:17 PM |
| OPHT | 10% Owner | May 24, 2016 | Sale | $49.00 | 1,300,000 | 63,700,000 | 3,610,489 | May 25, 2016, 05:17 PM |
| CRVS | 10% Owner | May 12, 2016 | Buy | $10.00 | 70,000 | 700,000 | 3,224,046 | May 16, 2016, 05:01 PM |
| CRVS | 10% Owner | Mar 29, 2016 | Buy | $15.00 | 666,666 | 9,999,990 | 3,154,046 | Mar 30, 2016, 01:07 PM |
| TBRA | 10% Owner | Mar 04, 2016 | Sale | $6.54 | 55,000 | 359,667 | 2,281,405 | Mar 04, 2016, 06:34 PM |
| TBRA | 10% Owner | Mar 03, 2016 | Sale | $6.86 | 25,000 | 171,395 | 2,336,405 | Mar 04, 2016, 06:34 PM |
| TBRA | 10% Owner | Mar 02, 2016 | Sale | $6.92 | 110,000 | 761,024 | 2,361,405 | Mar 04, 2016, 06:34 PM |
| TBRA | 10% Owner | Nov 18, 2015 | Sale | $9.76 | 153,601 | 1,498,685 | 2,471,405 | Nov 19, 2015, 05:55 PM |
| TBRA | 10% Owner | Nov 17, 2015 | Sale | $9.87 | 71,399 | 704,394 | 2,625,006 | Nov 19, 2015, 05:55 PM |
| FLXN | 10% Owner | Jun 22, 2015 | Sale | $20.55 | 63,412 | 1,302,844 | 2,133,131 | Jun 22, 2015, 06:22 PM |
| FLXN | 10% Owner | Jun 19, 2015 | Sale | $20.07 | 50,888 | 1,021,225 | 2,196,543 | Jun 22, 2015, 06:22 PM |
| FLXN | 10% Owner | Jun 18, 2015 | Sale | $21.51 | 35,700 | 767,903 | 2,247,431 | Jun 22, 2015, 06:22 PM |
| HTGM | 10% Owner | May 11, 2015 | Buy | $14.00 | 365,106 | 5,111,484 | 1,280,185 | May 12, 2015, 05:32 PM |
| CLCD | 10% Owner | May 11, 2015 | Buy | $10.00 | 1,300,000 | 13,000,000 | 3,056,563 | May 12, 2015, 05:31 PM |
| TBRA | 10% Owner | May 04, 2015 | Buy | $10.62 | 838,041 | 8,899,995 | 2,696,405 | May 06, 2015, 06:32 PM |
| OPHT | 10% Owner | Mar 25, 2015 | Option Exercise | $0.06 | 13,668 | 806 | 4,910,487 | Mar 26, 2015, 05:03 PM |
| OPHT | 10% Owner | Mar 05, 2015 | Sale | $51.75 | 1,005,000 | 52,008,750 | 4,896,819 | Mar 09, 2015, 07:01 PM |
| FLXN | 10% Owner | Dec 17, 2014 | Buy | $17.00 | 500,000 | 8,500,000 | 2,283,131 | Dec 18, 2014, 03:44 PM |
| NVRO | 10% Owner | Nov 12, 2014 | Buy | $18.00 | 215,000 | 3,870,000 | 2,194,841 | Nov 13, 2014, 12:52 PM |
| INGN | 10% Owner | Nov 04, 2014 | Sale | $21.50 | 2,000,000 | 43,000,000 | 3,549,320 | Nov 05, 2014, 02:28 PM |
| INGN | 10% Owner | Oct 15, 2014 | Option Exercise | $38961.30 | 129,871 | 5,059,943,094 | 5,549,320 | Oct 17, 2014, 11:19 AM |
| OTIC | 10% Owner | Aug 19, 2014 | Buy | $15.50 | 15,690 | 243,135 | 2,175,025 | Aug 21, 2014, 05:15 PM |
| OTIC | 10% Owner | Aug 18, 2014 | Buy | $16.00 | 171,875 | 2,750,000 | 2,159,335 | Aug 19, 2014, 04:52 PM |
| ZSPH | 10% Owner | Jun 23, 2014 | Buy | $18.00 | 275,000 | 4,950,000 | 781,730 | Jun 24, 2014, 04:34 PM |
| ALDR | 10% Owner | May 13, 2014 | Buy | $10.00 | 550,000 | 5,500,000 | 3,201,183 | May 14, 2014, 04:24 PM |
| AKBA | 10% Owner | Mar 25, 2014 | Buy | $17.00 | 182,590 | 3,104,030 | 1,516,387 | Mar 26, 2014, 05:44 PM |
| INGN | 10% Owner | Feb 20, 2014 | Sale | $14.88 | 617,000 | 9,180,960 | 5,419,449 | Feb 24, 2014, 05:10 PM |
| FLXN | 10% Owner | Feb 18, 2014 | Buy | $13.00 | 692,308 | 9,000,004 | 1,783,131 | Feb 20, 2014, 05:11 PM |
| OPHT | 10% Owner | Sep 30, 2013 | Buy | $22.00 | 455,000 | 10,010,000 | 6,896,819 | Oct 02, 2013, 08:15 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| CYT | 10% Owner | Jul 20, 2022 | Sale | 2,700,000 |
| BOLT | 10% Owner | Jul 13, 2022 | Sale | 1,600,000 |
| CMPI | 10% Owner | Feb 25, 2022 | Sale | 811 |
| CMPI | 10% Owner | Feb 24, 2022 | Sale | 16,979 |
| CMPI | 10% Owner | Feb 23, 2022 | Sale | 5,277 |
| ACLX | 10% Owner | Feb 08, 2022 | Buy | 12,499,995 |
| IOBT | 10% Owner | Nov 09, 2021 | Buy | 4,550,000 |
| UTRS | 10% Owner | Oct 26, 2021 | Buy | 6,960,000 |
| CYT | 10% Owner | Jun 22, 2021 | Buy | 4,999,986 |
| SPRB | 10% Owner | May 19, 2021 | Sale | 6,602,500 |
| RPHM | 10% Owner | Apr 13, 2021 | Buy | 9,999,990 |
| EWTX | 10% Owner | Mar 30, 2021 | Buy | 10,000,000 |
| INGN | 10% Owner | Mar 01, 2021 | Sale | 38,710,000 |
| GRTX | 10% Owner | Feb 18, 2021 | Sale | 5,290,000 |
| BOLT | 10% Owner | Feb 09, 2021 | Buy | 8,000,000 |
| INZY | 10% Owner | Jan 28, 2021 | Sale | 7,875,000 |
| GLTO | 10% Owner | Nov 02, 2020 | Buy | 4,999,995 |
| EAR | 10% Owner | Oct 20, 2020 | Buy | 2,700,000 |
| ALGS | 10% Owner | Oct 20, 2020 | Buy | 3,000,000 |
| GRTX | 10% Owner | Oct 15, 2020 | Sale | 4,950,000 |
| SPRB | 10% Owner | Oct 14, 2020 | Buy | 3,750,000 |
| HRMY | 10% Owner | Aug 21, 2020 | Buy | 3,180,072 |
| CMPI | 10% Owner | Aug 11, 2020 | Buy | 7,500,000 |
| INZY | 10% Owner | Jul 28, 2020 | Buy | 6,000,000 |
| NKTX | 10% Owner | Jul 14, 2020 | Buy | 9,999,990 |
| CRVS | 10% Owner | Jul 08, 2020 | Sale | 3,985,166 |
| CRVS | 10% Owner | Jul 07, 2020 | Sale | 4,183,381 |
| MIST | 10% Owner | Nov 25, 2019 | Sale | 3,840,000 |
| GRTX | 10% Owner | Nov 12, 2019 | Buy | 6,000,000 |
| CRVS | 10% Owner | Jul 25, 2019 | Sale | 5,600,000 |
| CRVS | 10% Owner | Jul 24, 2019 | Sale | 266,711 |
| CRVS | 10% Owner | Jul 23, 2019 | Sale | 211,134 |
| MIRM | 10% Owner | Jul 22, 2019 | Buy | 8,625,000 |
| MORF | 10% Owner | Jun 28, 2019 | Buy | 10,000,005 |
| MIST | 10% Owner | May 13, 2019 | Buy | 4,999,995 |
| ETTX | 10% Owner | Sep 28, 2018 | Buy | 16,347,525 |
| CRVS | 10% Owner | Mar 12, 2018 | Buy | 9,999,995 |
| KALV | 10% Owner | Oct 11, 2017 | Sale | 362,763 |
| KALV | 10% Owner | Oct 10, 2017 | Sale | 11,232,599 |
| KALV | 10% Owner | Oct 12, 2017 | Sale | 14,675,820 |
| KALV | 10% Owner | Sep 15, 2017 | Sale | 985,841 |
| KALV | 10% Owner | Sep 14, 2017 | Sale | 80,500 |
| KALV | 10% Owner | Sep 13, 2017 | Sale | 207,614 |
| KALV | 10% Owner | Sep 14, 2017 | Sale | 80,500 |
| KALV | 10% Owner | Sep 13, 2017 | Sale | 207,614 |
| KALV | 10% Owner | Sep 15, 2017 | Sale | 985,865 |
| HTGM | 10% Owner | Aug 25, 2017 | Sale | 1,260,591 |
| HTGM | 10% Owner | Aug 24, 2017 | Sale | 729,919 |
| HTGM | 10% Owner | Aug 23, 2017 | Sale | 95,475 |
| HTGM | 10% Owner | Aug 22, 2017 | Sale | 25,412 |
| HTGM | 10% Owner | Aug 21, 2017 | Sale | 25,976 |
| HTGM | 10% Owner | Aug 18, 2017 | Sale | 115,600 |
| ANAB | 10% Owner | Aug 21, 2017 | Sale | 7,518,251 |
| ANAB | 10% Owner | Aug 14, 2017 | Sale | 766,493 |
| ANAB | 10% Owner | Aug 15, 2017 | Sale | 3,011,988 |
| ANAB | 10% Owner | Aug 07, 2017 | Sale | 10,151,443 |
| ANAB | 10% Owner | Aug 04, 2017 | Sale | 225,963 |
| ANAB | 10% Owner | Aug 03, 2017 | Sale | 472,192 |
| ANAB | 10% Owner | Aug 02, 2017 | Sale | 613,485 |
| ANAB | 10% Owner | Aug 01, 2017 | Sale | 562,270 |
| APEN | 10% Owner | Jul 26, 2017 | Sale | 57,643 |
| APEN | 10% Owner | Jul 25, 2017 | Sale | 170,585 |
| APEN | 10% Owner | Jul 24, 2017 | Sale | 117,538 |
| CRVS | 10% Owner | Jun 23, 2017 | Buy | 219,000 |
| RETA | 10% Owner | Jun 13, 2017 | Sale | 290,073 |
| RETA | 10% Owner | Jun 14, 2017 | Sale | 1,241,853 |
| RETA | 10% Owner | Jun 12, 2017 | Sale | 2,282,824 |
| RETA | 10% Owner | Jun 09, 2017 | Sale | 56,955 |
| RETA | 10% Owner | Jun 08, 2017 | Sale | 3,380,000 |
| RETA | 10% Owner | Jun 06, 2017 | Sale | 1,802,490 |
| RETA | 10% Owner | Jun 05, 2017 | Sale | 668,825 |
| RETA | 10% Owner | Jun 07, 2017 | Sale | 56,079 |
| APEN | 10% Owner | May 11, 2017 | Sale | 582,094 |
| APEN | 10% Owner | May 10, 2017 | Sale | 8,608 |
| ANAB | 10% Owner | Jan 31, 2017 | Buy | 750,000 |
| OPHT | 10% Owner | Dec 14, 2016 | Sale | 10,962,378 |
| OPHT | 10% Owner | Dec 15, 2016 | Sale | 6,636,007 |
| RARX | 10% Owner | Oct 31, 2016 | Buy | 3,200,002 |
| IRTC | 10% Owner | Oct 25, 2016 | Buy | 1,700,000 |
| CLCD | 10% Owner | Sep 09, 2016 | Buy | 2,000,000 |
| TBRA | 10% Owner | Jul 12, 2016 | Sale | 106,072 |
| TBRA | 10% Owner | Jul 11, 2016 | Sale | 249,101 |
| TBRA | 10% Owner | Jul 13, 2016 | Sale | 354,944 |
| TBRA | 10% Owner | Jul 07, 2016 | Sale | 263,150 |
| TBRA | 10% Owner | Jul 06, 2016 | Sale | 730,272 |
| TBRA | 10% Owner | Jul 05, 2016 | Sale | 130,709 |
| TBRA | 10% Owner | Jun 30, 2016 | Sale | 341,368 |
| TBRA | 10% Owner | Jun 29, 2016 | Sale | 202,947 |
| TBRA | 10% Owner | Jun 28, 2016 | Sale | 326,626 |
| TBRA | 10% Owner | Jun 06, 2016 | Sale | 1,943,906 |
| RETA | 10% Owner | Jun 01, 2016 | Buy | 8,250,000 |
| OPHT | 10% Owner | May 24, 2016 | Sale | 63,700,000 |
| CRVS | 10% Owner | May 12, 2016 | Buy | 700,000 |
| CRVS | 10% Owner | Mar 29, 2016 | Buy | 9,999,990 |
| TBRA | 10% Owner | Mar 04, 2016 | Sale | 359,667 |
| TBRA | 10% Owner | Mar 03, 2016 | Sale | 171,395 |
| TBRA | 10% Owner | Mar 02, 2016 | Sale | 761,024 |
| TBRA | 10% Owner | Nov 18, 2015 | Sale | 1,498,685 |
| TBRA | 10% Owner | Nov 17, 2015 | Sale | 704,394 |
| FLXN | 10% Owner | Jun 22, 2015 | Sale | 1,302,844 |
| FLXN | 10% Owner | Jun 19, 2015 | Sale | 1,021,225 |
| FLXN | 10% Owner | Jun 18, 2015 | Sale | 767,903 |
| HTGM | 10% Owner | May 11, 2015 | Buy | 5,111,484 |
| CLCD | 10% Owner | May 11, 2015 | Buy | 13,000,000 |
| TBRA | 10% Owner | May 04, 2015 | Buy | 8,899,995 |
| OPHT | 10% Owner | Mar 25, 2015 | Option Exercise | 806 |
| OPHT | 10% Owner | Mar 05, 2015 | Sale | 52,008,750 |
| FLXN | 10% Owner | Dec 17, 2014 | Buy | 8,500,000 |
| NVRO | 10% Owner | Nov 12, 2014 | Buy | 3,870,000 |
| INGN | 10% Owner | Nov 04, 2014 | Sale | 43,000,000 |
| INGN | 10% Owner | Oct 15, 2014 | Option Exercise | 5,059,943,094 |
| OTIC | 10% Owner | Aug 19, 2014 | Buy | 243,135 |
| OTIC | 10% Owner | Aug 18, 2014 | Buy | 2,750,000 |
| ZSPH | 10% Owner | Jun 23, 2014 | Buy | 4,950,000 |
| ALDR | 10% Owner | May 13, 2014 | Buy | 5,500,000 |
| AKBA | 10% Owner | Mar 25, 2014 | Buy | 3,104,030 |
| INGN | 10% Owner | Feb 20, 2014 | Sale | 9,180,960 |
| FLXN | 10% Owner | Feb 18, 2014 | Buy | 9,000,004 |
| OPHT | 10% Owner | Sep 30, 2013 | Buy | 10,010,000 |