| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| AKBA | Director | Jun 03, 2022 | Sale | $0.36 | 4,567 | 1,653 | 43,430 | Jun 07, 2022, 04:03 PM |
| VCEL | Director | Apr 29, 2022 | Sale | $30.94 | 900 | 27,846 | 5,200 | May 02, 2022, 04:07 PM |
| VCEL | Director | Nov 29, 2021 | Option Exercise | $3.74 | 5,000 | 18,700 | 8,500 | Dec 01, 2021, 04:07 PM |
| VCEL | Director | Nov 29, 2021 | Sale | $39.17 | 5,000 | 195,855 | 3,500 | Dec 01, 2021, 04:07 PM |
| VCEL | Director | Oct 27, 2021 | Option Exercise | $3.74 | 5,000 | 18,700 | 8,500 | Oct 28, 2021, 04:12 PM |
| VCEL | Director | Oct 27, 2021 | Sale | $50.57 | 5,000 | 252,870 | 3,500 | Oct 28, 2021, 04:12 PM |
| VCEL | Director | Sep 30, 2021 | Option Exercise | $3.74 | 5,000 | 18,700 | 8,500 | Oct 01, 2021, 04:12 PM |
| VCEL | Director | Sep 30, 2021 | Sale | $48.85 | 5,000 | 244,255 | 3,500 | Oct 01, 2021, 04:12 PM |
| SCYX | Director | Dec 21, 2020 | Buy | $6.25 | 4,000 | 25,000 | 4,000 | Dec 23, 2020, 09:06 AM |
| MNTA | Director | Aug 05, 2020 | Option Exercise | $10.63 | 13,000 | 138,190 | 20,796 | Aug 07, 2020, 05:04 PM |
| MNTA | Director | Aug 05, 2020 | Sale | $32.75 | 13,000 | 425,750 | 7,796 | Aug 07, 2020, 05:04 PM |
| MNTA | Director | Jul 29, 2020 | Option Exercise | $10.63 | 10,000 | 106,300 | 17,796 | Jul 30, 2020, 07:03 PM |
| MNTA | Director | Jul 29, 2020 | Sale | $29.70 | 10,000 | 297,000 | 7,796 | Jul 30, 2020, 07:03 PM |
| MNTA | Director | Jul 22, 2020 | Option Exercise | $10.63 | 10,000 | 106,300 | 17,796 | Jul 23, 2020, 05:55 PM |
| MNTA | Director | Jul 22, 2020 | Sale | $33.23 | 10,000 | 332,300 | 7,796 | Jul 23, 2020, 05:55 PM |
| AKBA | Director | Jun 08, 2020 | Sale | $12.08 | 4,567 | 55,169 | 38,864 | Jun 09, 2020, 04:17 PM |
| AKBA | Director | Nov 20, 2019 | Buy | $3.43 | 5,800 | 19,894 | 29,731 | Nov 22, 2019, 06:20 AM |
| VCEL | Director | May 01, 2019 | Option Exercise | $2.76 | 7,500 | 20,700 | 7,500 | May 03, 2019, 04:07 PM |
| VCEL | Director | May 01, 2019 | Sale | $16.81 | 7,500 | 126,094 | 0 | May 03, 2019, 04:07 PM |
| VCEL | Director | Feb 28, 2019 | Option Exercise | $2.76 | 7,500 | 20,700 | 7,500 | Mar 04, 2019, 12:00 AM |
| VCEL | Director | Feb 28, 2019 | Sale | $18.02 | 7,500 | 135,129 | 0 | Mar 04, 2019, 12:00 AM |
| VCEL | Director | Dec 03, 2018 | Option Exercise | $2.63 | 8,500 | 22,355 | 8,500 | Dec 04, 2018, 04:05 PM |
| VCEL | Director | Dec 03, 2018 | Sale | $17.75 | 8,500 | 150,908 | 0 | Dec 04, 2018, 04:05 PM |
| VCEL | Director | Sep 04, 2018 | Option Exercise | $2.63 | 9,000 | 23,670 | 9,000 | Sep 06, 2018, 04:05 PM |
| VCEL | Director | Sep 04, 2018 | Sale | $12.03 | 9,000 | 108,270 | 0 | Sep 06, 2018, 04:05 PM |
| MNTA | Director | Jun 22, 2018 | Sale | $21.50 | 2,294 | 49,321 | 3,440 | Jun 26, 2018, 04:29 PM |
| KERX | Director | Jun 11, 2018 | Sale | $5.12 | 1,334 | 6,830 | 17,333 | Jun 12, 2018, 04:01 PM |
| KERX | Director | May 29, 2018 | Sale | $5.22 | 1,333 | 6,958 | 18,667 | May 31, 2018, 04:19 PM |
| CFRX | CEO | Jul 25, 2017 | Buy | $1.24 | 800 | 992 | 20,800 | Jul 26, 2017, 04:42 PM |
| CFRX | CEO | Jul 27, 2016 | Buy | $2.48 | 20,000 | 49,600 | 20,000 | Jul 27, 2016, 05:18 PM |
| CBST | EVP & Chief Scientific Officer | Jan 21, 2015 | Option Exercise | $102.00 | 30,531 | 3,114,162 | 0 | Jan 21, 2015, 05:07 PM |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2014 | Option Exercise | $59.96 | 82 | 4,917 | 27,680 | Jan 05, 2015, 04:00 PM |
| CBST | EVP & Chief Scientific Officer | Oct 01, 2014 | Option Exercise | $65.39 | 48,125 | 3,146,711 | 75,723 | Oct 02, 2014, 04:07 PM |
| CBST | EVP & Chief Scientific Officer | Oct 01, 2014 | Sale | $65.39 | 48,125 | 3,146,710 | 50,223 | Oct 02, 2014, 04:07 PM |
| CBST | EVP & Chief Scientific Officer | Jul 28, 2014 | Option Exercise | $25.23 | 40,625 | 1,024,969 | 68,223 | Jul 29, 2014, 04:01 PM |
| CBST | EVP & Chief Scientific Officer | Jul 28, 2014 | Sale | $61.57 | 40,625 | 2,501,104 | 34,123 | Jul 29, 2014, 04:01 PM |
| CBST | EVP & Chief Scientific Officer | Jun 30, 2014 | Option Exercise | $69.82 | 107 | 7,471 | 2,851 | Jul 02, 2014, 04:18 PM |
| CBST | EVP & Chief Scientific Officer | May 15, 2014 | Option Exercise | $16.76 | 15,125 | 253,495 | 42,723 | May 15, 2014, 02:43 PM |
| CBST | EVP & Chief Scientific Officer | May 15, 2014 | Sale | $67.82 | 16,340 | 1,108,240 | 33,823 | May 15, 2014, 02:43 PM |
| CBST | EVP & Chief Scientific Officer | May 14, 2014 | Sale | $69.00 | 1,680 | 115,920 | 26,313 | May 14, 2014, 04:11 PM |
| CBST | EVP & Chief Scientific Officer | Mar 31, 2014 | Option Exercise | $73.15 | 111 | 8,120 | 2,744 | Apr 02, 2014, 04:12 PM |
| CBST | EVP & Chief Scientific Officer | Feb 18, 2014 | Sale | $75.00 | 2,645 | 198,375 | 24,493 | Feb 19, 2014, 03:37 PM |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2013 | Option Exercise | $42.59 | 111 | 4,728 | 22,778 | Jan 02, 2014, 03:34 PM |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2014 | Option Exercise | $18.69 | 25,000 | 467,250 | 47,778 | Jan 02, 2014, 03:34 PM |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2014 | Sale | $67.82 | 25,000 | 1,695,443 | 23,288 | Jan 02, 2014, 03:34 PM |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2013 | Option Exercise | $42.59 | 111 | 4,728 | 23,540 | Jan 02, 2014, 03:15 PM |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2014 | Option Exercise | $18.69 | 25,000 | 467,250 | 48,540 | Jan 02, 2014, 03:15 PM |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2014 | Sale | $67.82 | 25,000 | 1,695,443 | 24,050 | Jan 02, 2014, 03:15 PM |
| CBST | EVP & Chief Scientific Officer | Jun 28, 2013 | Option Exercise | $48.29 | 154 | 7,437 | 2,633 | Jul 02, 2013, 02:40 PM |
| CBST | EVP & Chief Scientific Officer | Jun 28, 2013 | Option Exercise | $36.69 | 129 | 4,732 | 23,636 | Jul 02, 2013, 02:40 PM |
| CBST | EVP & Chief Scientific Officer | Jun 03, 2013 | Option Exercise | $16.76 | 15,125 | 253,495 | 38,632 | Jun 03, 2013, 06:00 PM |
| CBST | EVP & Chief Scientific Officer | Jun 03, 2013 | Sale | $54.49 | 15,125 | 824,204 | 23,507 | Jun 03, 2013, 06:00 PM |
| CBST | EVP & Chief Scientific Officer | May 16, 2013 | Sale | $48.88 | 1,201 | 58,700 | 23,507 | May 17, 2013, 12:33 PM |
| CBST | EVP & Chief Scientific Officer | May 15, 2013 | Sale | $48.41 | 1,017 | 49,238 | 22,208 | May 16, 2013, 03:45 PM |
| CBST | EVP & Chief Scientific Officer | May 14, 2013 | Sale | $49.18 | 1,135 | 55,818 | 20,725 | May 15, 2013, 05:16 PM |
| CBST | EVP & Chief Scientific Officer | Mar 28, 2013 | Option Exercise | $46.82 | 167 | 7,819 | 445 | Apr 02, 2013, 04:08 PM |
| CBST | EVP & Chief Scientific Officer | Feb 19, 2013 | Sale | $41.40 | 1,233 | 51,047 | 18,360 | Feb 20, 2013, 11:43 AM |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2012 | Option Exercise | $33.12 | 138 | 4,571 | 15,843 | Jan 03, 2013, 01:21 PM |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2013 | Option Exercise | $18.69 | 15,000 | 280,350 | 30,843 | Jan 03, 2013, 01:21 PM |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2013 | Sale | $42.98 | 15,000 | 644,745 | 15,843 | Jan 03, 2013, 01:21 PM |
| CBST | EVP & Chief Scientific Officer | Jun 29, 2012 | Option Exercise | $32.22 | 142 | 4,576 | 18,521 | Jul 03, 2012, 12:20 PM |
| CBST | EVP & Chief Scientific Officer | Jun 29, 2012 | Option Exercise | $37.91 | 147 | 5,573 | 2,181 | Jul 03, 2012, 12:20 PM |
| CBST | EVP & Chief Scientific Officer | May 17, 2012 | Option Exercise | $18.69 | 20,000 | 373,800 | 38,379 | May 17, 2012, 04:09 PM |
| CBST | EVP & Chief Scientific Officer | May 17, 2012 | Sale | $41.57 | 20,000 | 831,466 | 18,379 | May 17, 2012, 04:09 PM |
| CBST | EVP & Chief Scientific Officer | May 16, 2012 | Sale | $41.85 | 798 | 33,396 | 18,379 | May 16, 2012, 03:07 PM |
| CBST | EVP & Chief Scientific Officer | May 15, 2012 | Sale | $41.90 | 799 | 33,479 | 19,177 | May 16, 2012, 03:07 PM |
| CBST | EVP & Chief Scientific Officer | May 14, 2012 | Sale | $41.55 | 1,135 | 47,162 | 14,976 | May 15, 2012, 04:11 PM |
| CBST | EVP & Chief Scientific Officer | Mar 30, 2012 | Option Exercise | $43.25 | 131 | 5,666 | 12,611 | Apr 03, 2012, 04:15 PM |
| CBST | EVP & Chief Scientific Officer | Oct 26, 2011 | Option Exercise | $17.84 | 71,250 | 1,271,350 | 83,730 | Oct 28, 2011, 12:00 PM |
| CBST | EVP & Chief Scientific Officer | Oct 26, 2011 | Sale | $38.70 | 71,250 | 2,757,596 | 12,480 | Oct 28, 2011, 12:00 PM |
| CBST | EVP & Chief Scientific Officer | Sep 30, 2011 | Option Exercise | $35.32 | 11 | 389 | 12,480 | Oct 04, 2011, 09:53 AM |
| CBST | EVP & Chief Scientific Officer | Jun 30, 2011 | Option Exercise | $35.99 | 147 | 5,291 | 12,469 | Jul 05, 2011, 02:50 PM |
| CBST | EVP & Chief Scientific Officer | Mar 31, 2011 | Option Exercise | $25.24 | 211 | 5,326 | 7,322 | Apr 04, 2011, 01:48 PM |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2010 | Option Exercise | $17.36 | 604 | 10,484 | 7,111 | Jan 03, 2011, 01:30 PM |
| CBST | EVP & Chief Scientific Officer | Sep 30, 2010 | Option Exercise | $23.39 | 46 | 1,076 | 6,507 | Oct 04, 2010, 11:28 AM |
| Symbol | Relationship | Date | Transaction | Value($) |
| AKBA | Director | Jun 03, 2022 | Sale | 1,653 |
| VCEL | Director | Apr 29, 2022 | Sale | 27,846 |
| VCEL | Director | Nov 29, 2021 | Option Exercise | 18,700 |
| VCEL | Director | Nov 29, 2021 | Sale | 195,855 |
| VCEL | Director | Oct 27, 2021 | Option Exercise | 18,700 |
| VCEL | Director | Oct 27, 2021 | Sale | 252,870 |
| VCEL | Director | Sep 30, 2021 | Option Exercise | 18,700 |
| VCEL | Director | Sep 30, 2021 | Sale | 244,255 |
| SCYX | Director | Dec 21, 2020 | Buy | 25,000 |
| MNTA | Director | Aug 05, 2020 | Option Exercise | 138,190 |
| MNTA | Director | Aug 05, 2020 | Sale | 425,750 |
| MNTA | Director | Jul 29, 2020 | Option Exercise | 106,300 |
| MNTA | Director | Jul 29, 2020 | Sale | 297,000 |
| MNTA | Director | Jul 22, 2020 | Option Exercise | 106,300 |
| MNTA | Director | Jul 22, 2020 | Sale | 332,300 |
| AKBA | Director | Jun 08, 2020 | Sale | 55,169 |
| AKBA | Director | Nov 20, 2019 | Buy | 19,894 |
| VCEL | Director | May 01, 2019 | Option Exercise | 20,700 |
| VCEL | Director | May 01, 2019 | Sale | 126,094 |
| VCEL | Director | Feb 28, 2019 | Option Exercise | 20,700 |
| VCEL | Director | Feb 28, 2019 | Sale | 135,129 |
| VCEL | Director | Dec 03, 2018 | Option Exercise | 22,355 |
| VCEL | Director | Dec 03, 2018 | Sale | 150,908 |
| VCEL | Director | Sep 04, 2018 | Option Exercise | 23,670 |
| VCEL | Director | Sep 04, 2018 | Sale | 108,270 |
| MNTA | Director | Jun 22, 2018 | Sale | 49,321 |
| KERX | Director | Jun 11, 2018 | Sale | 6,830 |
| KERX | Director | May 29, 2018 | Sale | 6,958 |
| CFRX | CEO | Jul 25, 2017 | Buy | 992 |
| CFRX | CEO | Jul 27, 2016 | Buy | 49,600 |
| CBST | EVP & Chief Scientific Officer | Jan 21, 2015 | Option Exercise | 3,114,162 |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2014 | Option Exercise | 4,917 |
| CBST | EVP & Chief Scientific Officer | Oct 01, 2014 | Option Exercise | 3,146,711 |
| CBST | EVP & Chief Scientific Officer | Oct 01, 2014 | Sale | 3,146,710 |
| CBST | EVP & Chief Scientific Officer | Jul 28, 2014 | Option Exercise | 1,024,969 |
| CBST | EVP & Chief Scientific Officer | Jul 28, 2014 | Sale | 2,501,104 |
| CBST | EVP & Chief Scientific Officer | Jun 30, 2014 | Option Exercise | 7,471 |
| CBST | EVP & Chief Scientific Officer | May 15, 2014 | Option Exercise | 253,495 |
| CBST | EVP & Chief Scientific Officer | May 15, 2014 | Sale | 1,108,240 |
| CBST | EVP & Chief Scientific Officer | May 14, 2014 | Sale | 115,920 |
| CBST | EVP & Chief Scientific Officer | Mar 31, 2014 | Option Exercise | 8,120 |
| CBST | EVP & Chief Scientific Officer | Feb 18, 2014 | Sale | 198,375 |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2013 | Option Exercise | 4,728 |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2014 | Option Exercise | 467,250 |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2014 | Sale | 1,695,443 |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2013 | Option Exercise | 4,728 |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2014 | Option Exercise | 467,250 |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2014 | Sale | 1,695,443 |
| CBST | EVP & Chief Scientific Officer | Jun 28, 2013 | Option Exercise | 7,437 |
| CBST | EVP & Chief Scientific Officer | Jun 28, 2013 | Option Exercise | 4,732 |
| CBST | EVP & Chief Scientific Officer | Jun 03, 2013 | Option Exercise | 253,495 |
| CBST | EVP & Chief Scientific Officer | Jun 03, 2013 | Sale | 824,204 |
| CBST | EVP & Chief Scientific Officer | May 16, 2013 | Sale | 58,700 |
| CBST | EVP & Chief Scientific Officer | May 15, 2013 | Sale | 49,238 |
| CBST | EVP & Chief Scientific Officer | May 14, 2013 | Sale | 55,818 |
| CBST | EVP & Chief Scientific Officer | Mar 28, 2013 | Option Exercise | 7,819 |
| CBST | EVP & Chief Scientific Officer | Feb 19, 2013 | Sale | 51,047 |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2012 | Option Exercise | 4,571 |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2013 | Option Exercise | 280,350 |
| CBST | EVP & Chief Scientific Officer | Jan 02, 2013 | Sale | 644,745 |
| CBST | EVP & Chief Scientific Officer | Jun 29, 2012 | Option Exercise | 4,576 |
| CBST | EVP & Chief Scientific Officer | Jun 29, 2012 | Option Exercise | 5,573 |
| CBST | EVP & Chief Scientific Officer | May 17, 2012 | Option Exercise | 373,800 |
| CBST | EVP & Chief Scientific Officer | May 17, 2012 | Sale | 831,466 |
| CBST | EVP & Chief Scientific Officer | May 16, 2012 | Sale | 33,396 |
| CBST | EVP & Chief Scientific Officer | May 15, 2012 | Sale | 33,479 |
| CBST | EVP & Chief Scientific Officer | May 14, 2012 | Sale | 47,162 |
| CBST | EVP & Chief Scientific Officer | Mar 30, 2012 | Option Exercise | 5,666 |
| CBST | EVP & Chief Scientific Officer | Oct 26, 2011 | Option Exercise | 1,271,350 |
| CBST | EVP & Chief Scientific Officer | Oct 26, 2011 | Sale | 2,757,596 |
| CBST | EVP & Chief Scientific Officer | Sep 30, 2011 | Option Exercise | 389 |
| CBST | EVP & Chief Scientific Officer | Jun 30, 2011 | Option Exercise | 5,291 |
| CBST | EVP & Chief Scientific Officer | Mar 31, 2011 | Option Exercise | 5,326 |
| CBST | EVP & Chief Scientific Officer | Dec 31, 2010 | Option Exercise | 10,484 |
| CBST | EVP & Chief Scientific Officer | Sep 30, 2010 | Option Exercise | 1,076 |