| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| EPZM | 10% Owner | Feb 10, 2014 | Sale | $29.25 | 466,666 | 13,649,981 | 2,413,819 | Feb 11, 2014, 03:56 PM |
| CNAT | 10% Owner | Jul 30, 2013 | Option Exercise | $11.00 | 16,716 | 183,876 | 1,026,815 | Aug 01, 2013, 02:18 PM |
| CNAT | 10% Owner | Jul 30, 2013 | Buy | $11.00 | 165,265 | 1,817,915 | 1,192,080 | Aug 01, 2013, 02:18 PM |
| PCRX | Former 10% Owner | Mar 11, 2013 | Sale | $27.86 | 500,000 | 13,930,000 | 2,790,479 | Mar 13, 2013, 12:31 PM |
| PCRX | 10% Owner | Nov 21, 2011 | Buy | $6.50 | 461,538 | 2,999,997 | 3,290,479 | Nov 22, 2011, 02:04 PM |
| PCRX | 10% Owner | Feb 08, 2011 | Buy | $7.00 | 535,714 | 3,749,998 | 2,828,941 | Feb 17, 2011, 02:58 PM |
| PCRX | 10% Owner | Feb 08, 2012 | Buy | $7.00 | 535,714 | 3,749,998 | 2,828,941 | Feb 10, 2011, 04:27 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| EPZM | 10% Owner | Feb 10, 2014 | Sale | 13,649,981 |
| CNAT | 10% Owner | Jul 30, 2013 | Option Exercise | 183,876 |
| CNAT | 10% Owner | Jul 30, 2013 | Buy | 1,817,915 |
| PCRX | Former 10% Owner | Mar 11, 2013 | Sale | 13,930,000 |
| PCRX | 10% Owner | Nov 21, 2011 | Buy | 2,999,997 |
| PCRX | 10% Owner | Feb 08, 2011 | Buy | 3,749,998 |
| PCRX | 10% Owner | Feb 08, 2012 | Buy | 3,749,998 |