| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| ANTX | 10% Owner | Jun 21, 2022 | Buy | $7.99 | 302 | 2,413 | 3,748,389 | Jun 23, 2022, 04:31 PM |
| WVE | Director | Jun 16, 2022 | Buy | $2.15 | 9,480,052 | 20,382,113 | 17,202,009 | Jun 21, 2022, 04:33 PM |
| ANTX | 10% Owner | Jun 14, 2022 | Buy | $7.97 | 61,424 | 489,402 | 3,748,087 | Jun 15, 2022, 04:25 PM |
| ANTX | 10% Owner | Jun 13, 2022 | Buy | $7.90 | 20,000 | 158,000 | 3,686,663 | Jun 15, 2022, 04:25 PM |
| KALA | 10% Owner | May 26, 2022 | Sale | $0.36 | 1,005,686 | 365,667 | 7,039,613 | May 26, 2022, 05:09 PM |
| KALA | 10% Owner | May 23, 2022 | Sale | $0.65 | 1,250,000 | 812,500 | 9,624,613 | May 25, 2022, 05:17 PM |
| KALA | 10% Owner | May 25, 2022 | Sale | $0.42 | 1,434,509 | 602,494 | 8,045,299 | May 25, 2022, 05:17 PM |
| KALA | 10% Owner | May 24, 2022 | Sale | $0.51 | 144,805 | 73,851 | 9,479,808 | May 25, 2022, 05:17 PM |
| PEPG | Director | May 10, 2022 | Buy | $12.00 | 3,229,200 | 38,750,400 | 6,621,680 | May 12, 2022, 07:06 PM |
| NKTX | Director | Apr 26, 2022 | Buy | $15.00 | 2,200,000 | 33,000,000 | 7,805,129 | Apr 28, 2022, 04:32 PM |
| ANTX | 10% Owner | Mar 29, 2022 | Buy | $15.00 | 1,666,666 | 24,999,990 | 3,251,051 | Mar 31, 2022, 04:31 PM |
| ICVX | Director | Mar 28, 2022 | Buy | $4.53 | 175,318 | 794,611 | 5,953,665 | Mar 30, 2022, 04:31 PM |
| ICVX | Director | Mar 29, 2022 | Buy | $4.75 | 8,900 | 42,271 | 5,963,565 | Mar 30, 2022, 04:31 PM |
| CTKB | Director | Mar 15, 2022 | Buy | $12.27 | 241,727 | 2,964,999 | 13,381,054 | Mar 16, 2022, 05:10 PM |
| CTKB | Director | Mar 14, 2022 | Buy | $12.35 | 342,143 | 4,223,926 | 13,139,327 | Mar 16, 2022, 05:10 PM |
| CTKB | Director | Mar 09, 2022 | Buy | $12.99 | 40,154 | 521,753 | 12,202,700 | Mar 11, 2022, 05:27 PM |
| CTKB | Director | Mar 11, 2022 | Buy | $12.77 | 337,492 | 4,309,334 | 12,797,184 | Mar 11, 2022, 05:27 PM |
| CTKB | Director | Mar 10, 2022 | Buy | $12.95 | 256,992 | 3,327,584 | 12,459,692 | Mar 11, 2022, 05:27 PM |
| CTKB | Director | Mar 08, 2022 | Buy | $12.86 | 245,701 | 3,160,059 | 12,162,546 | Mar 08, 2022, 04:59 PM |
| CTKB | Director | Mar 07, 2022 | Buy | $12.61 | 337,901 | 4,260,965 | 11,916,845 | Mar 08, 2022, 04:59 PM |
| CTKB | Director | Mar 04, 2022 | Buy | $12.99 | 63,662 | 827,230 | 11,578,944 | Mar 08, 2022, 04:59 PM |
| CTKB | Director | Feb 28, 2022 | Buy | $12.97 | 8,746 | 113,430 | 11,082,163 | Mar 02, 2022, 05:29 PM |
| CTKB | Director | Mar 02, 2022 | Buy | $12.89 | 138,255 | 1,782,218 | 11,515,282 | Mar 02, 2022, 05:29 PM |
| CTKB | Director | Mar 01, 2022 | Buy | $12.98 | 294,864 | 3,826,303 | 11,377,027 | Mar 02, 2022, 05:29 PM |
| CTKB | Director | Feb 25, 2022 | Buy | $12.99 | 18,991 | 246,699 | 11,073,417 | Feb 25, 2022, 05:43 PM |
| CTKB | Director | Feb 24, 2022 | Buy | $13.03 | 186,467 | 2,429,852 | 11,054,426 | Feb 25, 2022, 05:43 PM |
| CTKB | Director | Feb 23, 2022 | Buy | $13.41 | 214,922 | 2,883,114 | 10,867,959 | Feb 25, 2022, 05:43 PM |
| CTKB | Director | Feb 18, 2022 | Buy | $14.12 | 166,229 | 2,346,389 | 10,438,115 | Feb 22, 2022, 05:22 PM |
| CTKB | Director | Feb 17, 2022 | Buy | $14.78 | 166,229 | 2,457,264 | 10,271,886 | Feb 22, 2022, 05:22 PM |
| CTKB | Director | Feb 22, 2022 | Buy | $13.46 | 214,922 | 2,892,055 | 10,653,037 | Feb 22, 2022, 05:22 PM |
| CTKB | Director | Feb 16, 2022 | Buy | $14.98 | 166,200 | 2,489,377 | 10,105,657 | Feb 16, 2022, 07:39 PM |
| CTKB | Director | Feb 15, 2022 | Buy | $14.99 | 166,200 | 2,490,524 | 9,939,457 | Feb 16, 2022, 07:39 PM |
| CTKB | Director | Feb 14, 2022 | Buy | $14.72 | 166,229 | 2,446,924 | 9,773,257 | Feb 16, 2022, 07:39 PM |
| DICE | Director | Sep 17, 2021 | Buy | $17.00 | 1,400,000 | 23,800,000 | 4,422,504 | Sep 20, 2021, 04:30 PM |
| TYRA | Director | Sep 17, 2021 | Buy | $16.00 | 1,250,000 | 20,000,000 | 5,297,120 | Sep 17, 2021, 04:34 PM |
| ELYM | Director | Aug 12, 2021 | Buy | $12.50 | 3,200,000 | 40,000,000 | 10,599,586 | Aug 16, 2021, 04:47 PM |
| ICVX | Director | Aug 02, 2021 | Buy | $15.00 | 2,666,666 | 39,999,990 | 5,140,679 | Aug 04, 2021, 04:31 PM |
| CTKB | Director | Jul 27, 2021 | Buy | $17.00 | 2,950,000 | 50,150,000 | 7,913,537 | Jul 29, 2021, 04:30 PM |
| ABOS | Director | Jul 06, 2021 | Buy | $16.00 | 1,875,000 | 30,000,000 | 7,881,889 | Jul 08, 2021, 04:32 PM |
| AVTE | Director | Jul 02, 2021 | Buy | $14.00 | 2,785,714 | 38,999,996 | 6,965,568 | Jul 06, 2021, 05:03 PM |
| RACA | Director | Jun 29, 2021 | Buy | $10.00 | 209,100 | 2,091,000 | 1,098,318 | Jun 30, 2021, 04:30 PM |
| ETNB | Director | Jun 02, 2021 | Buy | $18.77 | 22,138 | 415,530 | 4,965,769 | Jun 04, 2021, 04:31 PM |
| HOWL | Director | May 04, 2021 | Buy | $16.00 | 1,715,000 | 27,440,000 | 3,524,758 | May 06, 2021, 04:31 PM |
| SLDB | Director | Mar 19, 2021 | Buy | $5.75 | 2,206,685 | 12,688,439 | 10,916,567 | Mar 23, 2021, 04:30 PM |
| SCPH | 10% Owner | Mar 15, 2021 | Sale | $7.03 | 110,588 | 777,787 | 2,727,446 | Mar 16, 2021, 04:30 PM |
| SCPH | 10% Owner | Mar 12, 2021 | Sale | $7.22 | 39,469 | 284,816 | 2,838,034 | Mar 16, 2021, 04:30 PM |
| PHAT | 10% Owner | Mar 11, 2021 | Sale | $43.75 | 710,000 | 31,062,500 | 3,115,008 | Mar 15, 2021, 04:36 PM |
| STSA | Director | Feb 26, 2021 | Buy | $5.68 | 1,232,394 | 6,999,998 | 5,155,854 | Mar 02, 2021, 04:30 PM |
| VOR | Director | Feb 09, 2021 | Buy | $18.00 | 2,979,566 | 53,632,188 | 8,297,265 | Feb 09, 2021, 06:25 PM |
| RYTM | Former 10% Owner | Dec 03, 2020 | Sale | $29.03 | 207,604 | 6,027,391 | 4,557,882 | Dec 04, 2020, 04:30 PM |
| RYTM | Former 10% Owner | Dec 02, 2020 | Sale | $32.39 | 30,939 | 1,002,261 | 4,580,524 | Dec 04, 2020, 04:30 PM |
| ORTX | 10% Owner | Aug 18, 2020 | Buy | $4.72 | 45,249 | 213,575 | 9,216,011 | Nov 06, 2020, 04:32 PM |
| ORTX | 10% Owner | Aug 17, 2020 | Buy | $4.74 | 8,235 | 39,034 | 9,170,762 | Nov 06, 2020, 04:32 PM |
| ORTX | 10% Owner | Sep 24, 2020 | Buy | $4.61 | 473,327 | 2,182,038 | 9,880,865 | Nov 06, 2020, 04:32 PM |
| ORTX | 10% Owner | Aug 14, 2020 | Buy | $4.74 | 13,031 | 61,767 | 9,162,527 | Nov 06, 2020, 04:32 PM |
| ORTX | 10% Owner | Aug 21, 2020 | Buy | $4.62 | 64,642 | 298,609 | 9,407,538 | Nov 06, 2020, 04:32 PM |
| ORTX | 10% Owner | Aug 12, 2020 | Buy | $4.74 | 16,291 | 77,219 | 9,149,496 | Nov 06, 2020, 04:32 PM |
| ORTX | 10% Owner | Aug 20, 2020 | Buy | $4.61 | 62,631 | 288,729 | 9,342,896 | Nov 06, 2020, 04:32 PM |
| ORTX | 10% Owner | Aug 10, 2020 | Buy | $4.74 | 21,357 | 101,174 | 9,133,205 | Nov 06, 2020, 04:32 PM |
| ORTX | 10% Owner | Aug 19, 2020 | Buy | $4.68 | 64,254 | 300,989 | 9,280,265 | Nov 06, 2020, 04:32 PM |
| PCVX | 10% Owner | Oct 08, 2020 | Sale | $50.69 | 167,661 | 8,498,066 | 5,001,593 | Oct 09, 2020, 04:22 PM |
| PCVX | 10% Owner | Oct 07, 2020 | Sale | $50.95 | 98,597 | 5,023,527 | 5,169,254 | Oct 09, 2020, 04:22 PM |
| PCVX | 10% Owner | Oct 01, 2020 | Sale | $48.64 | 15,967 | 776,705 | 5,267,851 | Oct 01, 2020, 05:25 PM |
| PCVX | 10% Owner | Sep 30, 2020 | Sale | $50.27 | 124,656 | 6,265,871 | 5,283,818 | Oct 01, 2020, 05:25 PM |
| PCVX | 10% Owner | Sep 29, 2020 | Sale | $52.08 | 80,707 | 4,202,986 | 5,408,474 | Oct 01, 2020, 05:25 PM |
| PMVP | 10% Owner | Sep 29, 2020 | Buy | $18.00 | 950,000 | 17,100,000 | 1,710,265 | Sep 29, 2020, 04:30 PM |
| DYN | 10% Owner | Sep 21, 2020 | Buy | $19.00 | 660,000 | 12,540,000 | 2,805,045 | Sep 23, 2020, 06:55 PM |
| ETNB | Director | Sep 17, 2020 | Buy | $28.00 | 1,300,000 | 36,400,000 | 4,736,214 | Sep 21, 2020, 04:30 PM |
| TGTX | 10% Owner | Sep 09, 2020 | Sale | $25.81 | 158,589 | 4,092,738 | 12,629,868 | Sep 11, 2020, 04:31 PM |
| ITOS | 10% Owner | Jul 28, 2020 | Buy | $19.00 | 1,425,000 | 27,075,000 | 4,417,259 | Jul 29, 2020, 09:35 PM |
| INZY | 10% Owner | Jul 28, 2020 | Buy | $16.00 | 600,000 | 9,600,000 | 2,003,653 | Jul 28, 2020, 06:33 PM |
| PAND | 10% Owner | Jul 21, 2020 | Buy | $18.00 | 361,111 | 6,499,998 | 1,770,023 | Jul 22, 2020, 04:30 PM |
| NKTX | 10% Owner | Jul 14, 2020 | Buy | $18.00 | 3,333,333 | 59,999,994 | 5,605,129 | Jul 16, 2020, 04:30 PM |
| ETNB | Director | Jul 08, 2020 | Buy | $27.50 | 275,000 | 7,562,500 | 3,436,214 | Jul 10, 2020, 04:32 PM |
| RYTM | 10% Owner | Jul 01, 2020 | Sale | $21.87 | 25,527 | 558,311 | 5,184,561 | Jul 02, 2020, 04:46 PM |
| RYTM | 10% Owner | Jun 30, 2020 | Sale | $22.15 | 61,901 | 1,371,237 | 5,210,088 | Jul 02, 2020, 04:46 PM |
| RYTM | 10% Owner | Jul 02, 2020 | Sale | $22.04 | 44,153 | 972,969 | 5,140,408 | Jul 02, 2020, 04:46 PM |
| AKUS | 10% Owner | Jun 30, 2020 | Buy | $17.00 | 825,000 | 14,025,000 | 2,281,249 | Jul 02, 2020, 12:00 AM |
| RYTM | 10% Owner | Jun 29, 2020 | Sale | $22.19 | 52,049 | 1,154,999 | 5,271,989 | Jun 29, 2020, 06:31 PM |
| RYTM | 10% Owner | Jun 26, 2020 | Sale | $23.31 | 86,706 | 2,020,848 | 5,324,038 | Jun 29, 2020, 06:31 PM |
| RYTM | 10% Owner | Jun 25, 2020 | Sale | $25.05 | 11,568 | 289,768 | 5,410,744 | Jun 29, 2020, 06:31 PM |
| VSTM | 10% Owner | Jun 25, 2020 | Sale | $1.91 | 1,161,300 | 2,219,941 | 16,142,051 | Jun 29, 2020, 06:29 PM |
| FMTX | 10% Owner | Jun 23, 2020 | Buy | $20.00 | 4,000,000 | 80,000,000 | 9,011,651 | Jun 24, 2020, 09:20 PM |
| VSTM | 10% Owner | Apr 27, 2020 | Sale | $2.31 | 1,301,300 | 3,002,099 | 17,303,351 | Apr 29, 2020, 04:30 PM |
| PHAT | 10% Owner | Apr 01, 2020 | Buy | $24.86 | 117,600 | 2,923,642 | 3,825,008 | Apr 03, 2020, 04:30 PM |
| RARX | Director | Apr 02, 2020 | Option Exercise | $48.00 | 4,858,260 | 233,196,480 | 0 | Apr 03, 2020, 12:00 AM |
| PHAT | 10% Owner | Mar 27, 2020 | Buy | $24.60 | 30,000 | 738,000 | 3,676,808 | Mar 31, 2020, 05:02 PM |
| PHAT | 10% Owner | Mar 31, 2020 | Buy | $24.55 | 30,600 | 751,264 | 3,707,408 | Mar 31, 2020, 05:02 PM |
| IMRA | 10% Owner | Mar 16, 2020 | Buy | $16.00 | 625,000 | 10,000,000 | 1,454,348 | Mar 17, 2020, 04:31 PM |
| KALA | Director | Mar 13, 2020 | Buy | $7.89 | 6,337,135 | 49,999,994 | 10,874,613 | Mar 13, 2020, 06:45 PM |
| SCPH | 10% Owner | Feb 14, 2020 | Buy | $8.20 | 271,993 | 2,230,343 | 3,518,998 | Feb 21, 2020, 04:46 PM |
| SCPH | 10% Owner | Feb 14, 2020 | Buy | $8.20 | 271,993 | 2,230,343 | 3,247,005 | Feb 19, 2020, 12:00 AM |
| THOR | 10% Owner | Jan 23, 2020 | Option Exercise | $68.00 | 9,724,598 | 661,272,664 | 0 | Jan 24, 2020, 05:53 PM |
| THOR | 10% Owner | Jan 23, 2020 | Option Exercise | $68.00 | 9,724,598 | 661,272,664 | 0 | Jan 24, 2020, 05:11 PM |
| ETNB | Director | Nov 11, 2019 | Buy | $16.00 | 1,500,000 | 24,000,000 | 1,500,000 | Nov 13, 2019, 07:06 PM |
| STSA | Director | Sep 17, 2019 | Buy | $15.00 | 1,333,333 | 19,999,995 | 4,681,858 | Sep 17, 2019, 05:04 PM |
| SCPH | 10% Owner | Apr 11, 2019 | Buy | $2.70 | 389,862 | 1,052,627 | 3,247,005 | Apr 15, 2019, 04:31 PM |
| WVE | Director | Jan 24, 2019 | Buy | $38.00 | 263,158 | 10,000,004 | 7,775,207 | Jan 28, 2019, 04:33 PM |
| RARX | Director | Dec 12, 2018 | Buy | $15.50 | 1,006,452 | 15,600,006 | 4,858,260 | Dec 14, 2018, 06:17 PM |
| THOR | 10% Owner | Dec 11, 2018 | Buy | $11.00 | 4,545,455 | 50,000,005 | 9,724,598 | Dec 13, 2018, 06:30 PM |
| KALA | Director | Oct 03, 2018 | Buy | $8.25 | 2,424,242 | 19,999,997 | 4,537,478 | Oct 05, 2018, 04:33 PM |
| ARVN | Former 10% Owner | Oct 01, 2018 | Buy | $16.00 | 1,000,000 | 16,000,000 | 3,138,412 | Oct 03, 2018, 04:36 PM |
| EIDX | Director | Jun 22, 2018 | Buy | $17.00 | 1,058,824 | 18,000,008 | 2,162,671 | Jun 22, 2018, 07:33 PM |
| RARX | Director | Feb 14, 2018 | Buy | $6.00 | 2,500,000 | 15,000,000 | 3,851,808 | Feb 16, 2018, 04:42 PM |
| WVE | Director | Nov 14, 2017 | Buy | $24.00 | 23,398 | 561,550 | 7,512,049 | Nov 15, 2017, 04:35 PM |
| WVE | Director | Nov 13, 2017 | Buy | $23.30 | 400,000 | 9,320,000 | 7,488,651 | Nov 15, 2017, 04:35 PM |
| KALV | Director | Oct 12, 2017 | Buy | $8.50 | 850,000 | 7,225,000 | 1,441,070 | Oct 16, 2017, 04:32 PM |
| KALA | Director | Jul 25, 2017 | Buy | $15.00 | 533,333 | 7,999,995 | 2,113,236 | Jul 26, 2017, 04:44 PM |
| GTHX | Fmr 10% Owner See Footnote (2) | May 22, 2017 | Buy | $15.00 | 400,000 | 6,000,000 | 2,684,244 | May 24, 2017, 04:34 PM |
| RARX | Director | Oct 31, 2016 | Buy | $13.00 | 161,538 | 2,099,994 | 1,351,808 | Oct 31, 2016, 07:41 PM |
| ACRS | 10% Owner | Sep 16, 2016 | Sale | $24.51 | 173,600 | 4,254,212 | 2,125,769 | Sep 19, 2016, 05:15 PM |
| ACRS | 10% Owner | Sep 15, 2016 | Sale | $24.04 | 351,950 | 8,459,290 | 2,607,719 | Sep 19, 2016, 05:15 PM |
| ACRS | 10% Owner | Feb 22, 2016 | Buy | $15.99 | 11,318 | 180,958 | 2,599,311 | Feb 24, 2016, 04:56 PM |
| ACRS | 10% Owner | Feb 23, 2016 | Buy | $17.62 | 28,408 | 500,512 | 2,627,719 | Feb 24, 2016, 04:56 PM |
| ACRS | 10% Owner | Jan 20, 2016 | Buy | $19.88 | 1,803 | 35,849 | 2,587,993 | Jan 20, 2016, 04:51 PM |
| ACRS | 10% Owner | Jan 19, 2016 | Buy | $19.88 | 4,200 | 83,480 | 2,586,190 | Jan 20, 2016, 04:51 PM |
| ACRS | 10% Owner | Jan 15, 2016 | Buy | $19.86 | 1,800 | 35,743 | 2,581,990 | Jan 20, 2016, 04:51 PM |
| ACRS | 10% Owner | Jan 11, 2016 | Buy | $17.93 | 4,153 | 74,479 | 2,568,706 | Jan 13, 2016, 04:39 PM |
| ACRS | 10% Owner | Jan 13, 2016 | Buy | $19.97 | 5,543 | 110,674 | 2,580,190 | Jan 13, 2016, 04:39 PM |
| ACRS | 10% Owner | Jan 12, 2016 | Buy | $19.12 | 5,941 | 113,585 | 2,574,647 | Jan 13, 2016, 04:39 PM |
| WVE | Director | Nov 16, 2015 | Buy | $16.00 | 1,875,000 | 30,000,000 | 7,088,651 | Nov 18, 2015, 05:30 PM |
| ACRS | 10% Owner | Oct 29, 2015 | Buy | $14.00 | 95,000 | 1,330,000 | 2,564,552 | Oct 30, 2015, 03:53 PM |
| ACRS | 10% Owner | Oct 28, 2015 | Buy | $14.00 | 149,200 | 2,088,800 | 2,469,552 | Oct 30, 2015, 03:53 PM |
| ACRS | 10% Owner | Oct 22, 2015 | Buy | $14.03 | 5,410 | 75,883 | 2,320,352 | Oct 26, 2015, 04:17 PM |
| ACRS | 10% Owner | Oct 19, 2015 | Buy | $14.88 | 23,934 | 356,049 | 2,303,877 | Oct 21, 2015, 04:35 PM |
| ACRS | 10% Owner | Oct 21, 2015 | Buy | $14.83 | 3,100 | 45,976 | 2,314,942 | Oct 21, 2015, 04:35 PM |
| ACRS | 10% Owner | Oct 20, 2015 | Buy | $14.95 | 7,965 | 119,070 | 2,311,842 | Oct 21, 2015, 04:35 PM |
| ACRS | 10% Owner | Oct 14, 2015 | Buy | $14.06 | 42,813 | 601,792 | 2,279,943 | Oct 16, 2015, 04:17 PM |
| ACRS | 10% Owner | Oct 08, 2015 | Buy | $11.00 | 21,691 | 238,555 | 2,237,130 | Oct 13, 2015, 09:34 AM |
| ACRS | 10% Owner | Oct 07, 2015 | Buy | $10.86 | 2,215,439 | 24,051,364 | 2,215,439 | Oct 13, 2015, 09:34 AM |
| SGMO | Former 10% Owner | Jul 17, 2014 | Buy | $12.26 | 37,215 | 456,211 | 2,199,753 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jul 01, 2014 | Sale | $16.01 | 82,700 | 1,323,999 | 2,212,158 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jul 29, 2014 | Sale | $12.41 | 1,407 | 17,464 | 1,966,786 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jun 16, 2014 | Sale | $16.55 | 250,500 | 4,146,531 | 2,493,900 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jul 28, 2014 | Sale | $12.11 | 60,081 | 727,474 | 2,003,464 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jun 09, 2014 | Sale | $15.50 | 83,500 | 1,294,159 | 2,518,283 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jul 25, 2014 | Sale | $12.31 | 47,429 | 583,951 | 2,028,274 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jun 06, 2014 | Sale | $14.29 | 135,101 | 1,930,949 | 2,704,487 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jul 24, 2014 | Sale | $12.28 | 124,050 | 1,523,235 | 2,075,703 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Aug 01, 2014 | Sale | $12.82 | 27,770 | 356,100 | 1,829,426 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jun 05, 2014 | Sale | $14.13 | 115,102 | 1,626,669 | 2,763,188 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | Jul 30, 2014 | Sale | $12.42 | 109,590 | 1,361,606 | 1,946,194 | Feb 18, 2015, 09:54 PM |
| SGMO | Former 10% Owner | May 07, 2014 | Buy | $12.09 | 35,736 | 431,870 | 4,857,972 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | Jun 05, 2014 | Sale | $13.06 | 970,361 | 12,669,888 | 2,881,303 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | May 08, 2014 | Sale | $12.40 | 83,300 | 1,032,587 | 4,837,147 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | May 27, 2014 | Sale | $13.55 | 263,437 | 3,570,473 | 4,426,386 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | Jun 04, 2014 | Sale | $13.10 | 70,640 | 925,227 | 3,849,783 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | May 23, 2014 | Sale | $13.27 | 51,597 | 684,713 | 4,580,960 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | Jun 03, 2014 | Sale | $12.86 | 76,833 | 988,072 | 3,870,442 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | May 22, 2014 | Sale | $13.56 | 56,396 | 764,537 | 4,673,375 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | May 30, 2014 | Sale | $13.40 | 65,884 | 883,147 | 3,971,508 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | May 13, 2014 | Sale | $13.12 | 56,060 | 735,305 | 4,688,953 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | May 29, 2014 | Sale | $13.53 | 155,675 | 2,106,559 | 4,159,444 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | May 12, 2014 | Sale | $13.03 | 29,659 | 386,330 | 4,755,283 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | May 28, 2014 | Sale | $13.43 | 148,689 | 1,996,952 | 4,193,136 | Feb 18, 2015, 09:53 PM |
| SGMO | Former 10% Owner | Apr 25, 2014 | Buy | $13.63 | 166,000 | 2,262,779 | 4,575,328 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 07, 2014 | Buy | $15.42 | 33,667 | 519,310 | 4,475,024 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 11, 2014 | Buy | $14.48 | 116,992 | 1,694,299 | 4,723,633 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 04, 2014 | Buy | $15.38 | 179,031 | 2,753,712 | 4,441,357 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 17, 2014 | Buy | $14.02 | 41,500 | 581,959 | 4,762,078 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | May 07, 2014 | Buy | $11.73 | 47,564 | 557,989 | 4,822,236 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 03, 2014 | Buy | $16.61 | 195,126 | 3,241,999 | 4,262,326 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 10, 2014 | Buy | $14.91 | 83,000 | 1,237,339 | 4,610,044 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 30, 2014 | Buy | $13.45 | 124,500 | 1,674,679 | 4,774,672 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 15, 2014 | Buy | $13.16 | 21,829 | 287,206 | 4,742,407 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 28, 2014 | Buy | $13.29 | 74,844 | 995,014 | 4,650,172 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 08, 2014 | Buy | $15.49 | 121,876 | 1,888,274 | 4,596,900 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 22, 2014 | Sale | $14.86 | 352,750 | 5,243,538 | 4,722,487 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 10, 2014 | Sale | $15.67 | 3,403 | 53,326 | 4,606,641 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 16, 2014 | Sale | $14.09 | 21,829 | 307,658 | 4,720,578 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 09, 2014 | Sale | $16.27 | 69,856 | 1,136,424 | 4,527,044 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Apr 14, 2014 | Sale | $14.78 | 3,055 | 45,165 | 4,720,578 | Feb 18, 2015, 09:52 PM |
| SGMO | Former 10% Owner | Mar 27, 2014 | Buy | $17.65 | 256,187 | 4,522,356 | 4,233,200 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 17, 2014 | Buy | $23.02 | 52,161 | 1,200,835 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 26, 2014 | Buy | $18.14 | 210,013 | 3,808,711 | 3,977,013 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 13, 2014 | Buy | $22.76 | 71,319 | 1,623,356 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 25, 2014 | Buy | $19.42 | 84,000 | 1,631,041 | 3,767,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 21, 2014 | Buy | $21.22 | 101,808 | 2,159,989 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 10, 2014 | Buy | $22.30 | 12,522 | 279,180 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 28, 2014 | Buy | $17.10 | 84,000 | 1,436,056 | 4,317,200 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 07, 2014 | Buy | $22.25 | 258,377 | 5,748,552 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 06, 2014 | Sale | $24.10 | 61,483 | 1,481,538 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 12, 2014 | Sale | $23.40 | 123,480 | 2,889,432 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Apr 01, 2014 | Sale | $18.01 | 250,000 | 4,502,381 | 4,268,700 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 19, 2014 | Sale | $24.28 | 17,808 | 432,432 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Mar 18, 2014 | Sale | $23.74 | 84,000 | 1,994,573 | 3,683,000 | Feb 18, 2015, 09:51 PM |
| SGMO | Former 10% Owner | Feb 05, 2014 | Buy | $18.23 | 42,000 | 765,828 | 3,725,002 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 26, 2014 | Buy | $19.57 | 74,194 | 1,452,243 | 3,757,196 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 12, 2014 | Buy | $18.04 | 42,000 | 757,621 | 3,767,002 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Mar 06, 2014 | Buy | $22.50 | 84,001 | 1,890,245 | 3,683,000 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 11, 2014 | Buy | $19.65 | 42,000 | 825,275 | 3,725,002 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 28, 2014 | Buy | $18.10 | 42,000 | 760,145 | 3,767,000 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 27, 2014 | Sale | $19.37 | 32,196 | 623,499 | 3,742,243 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 13, 2014 | Sale | $18.46 | 15,409 | 284,438 | 3,751,593 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Mar 06, 2014 | Sale | $23.28 | 293,417 | 6,831,412 | 3,683,000 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 20, 2014 | Sale | $18.40 | 35,319 | 649,869 | 3,718,282 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 19, 2014 | Sale | $18.51 | 6,720 | 124,420 | 3,718,321 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Mar 03, 2014 | Sale | $18.21 | 84,000 | 1,529,902 | 3,699,800 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 07, 2014 | Sale | $18.52 | 34,688 | 642,432 | 3,683,002 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 18, 2014 | Sale | $18.11 | 11,172 | 202,278 | 3,725,041 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 06, 2014 | Sale | $18.42 | 7,312 | 134,683 | 3,717,690 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner | Feb 14, 2014 | Sale | $18.61 | 15,380 | 286,166 | 3,736,213 | Feb 18, 2015, 09:49 PM |
| SGMO | Former 10% Owner. | Dec 13, 2013 | Buy | $12.09 | 5,040 | 60,921 | 4,043,002 | Feb 18, 2015, 06:38 PM |
| SGMO | Former 10% Owner. | Dec 12, 2013 | Buy | $12.09 | 9,600 | 116,071 | 4,037,962 | Feb 18, 2015, 06:38 PM |
| SGMO | Former 10% Owner. | Jan 09, 2014 | Sale | $18.35 | 72,440 | 1,329,365 | 4,015,519 | Feb 18, 2015, 06:38 PM |
| SGMO | Former 10% Owner | Jul 17, 2013 | Buy | $9.79 | 19,200 | 187,895 | 3,645,703 | Feb 18, 2015, 06:37 PM |
| SGMO | Former 10% Owner | Jul 23, 2013 | Sale | $9.37 | 5,012 | 46,938 | 3,487,088 | Feb 18, 2015, 06:37 PM |
| SGMO | Former 10% Owner | Jul 22, 2013 | Sale | $9.57 | 111,363 | 1,065,610 | 3,526,662 | Feb 18, 2015, 06:37 PM |
| SGMO | Former 10% Owner | Jul 19, 2013 | Sale | $9.84 | 209,894 | 2,065,714 | 3,603,463 | Feb 18, 2015, 06:37 PM |
| SGMO | Former 10% Owner | Jul 18, 2013 | Sale | $10.02 | 74,035 | 741,498 | 3,626,503 | Feb 18, 2015, 06:37 PM |
| SGMO | Former 10% Owner | Jul 17, 2013 | Sale | $10.22 | 48,270 | 493,401 | 3,626,503 | Feb 18, 2015, 06:37 PM |
| SGMO | Former 10% Owner | Jul 25, 2013 | Sale | $9.71 | 368,870 | 3,582,848 | 3,483,017 | Feb 18, 2015, 06:37 PM |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 30, 2013 | Buy | $3.50 | 1,552,000 | 5,432,000 | 4,816,562 | Jan 20, 2015, 06:10 PM |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 27, 2013 | Buy | $4.00 | 600,000 | 2,400,000 | 5,416,562 | Jan 20, 2015, 06:10 PM |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 20, 2013 | Sale | $7.40 | 26,539 | 196,481 | 5,039,346 | Jan 20, 2015, 06:10 PM |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 18, 2013 | Sale | $7.48 | 2,328 | 17,413 | 5,037,018 | Jan 20, 2015, 06:10 PM |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 17, 2013 | Sale | $7.42 | 77,600 | 575,994 | 4,959,418 | Jan 20, 2015, 06:10 PM |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 25, 2013 | Sale | $7.26 | 135,800 | 985,908 | 5,280,762 | Jan 20, 2015, 06:10 PM |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 16, 2013 | Sale | $7.53 | 91,801 | 690,913 | 4,867,617 | Jan 20, 2015, 06:10 PM |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 24, 2013 | Sale | $7.34 | 181,429 | 1,330,789 | 5,230,711 | Jan 20, 2015, 06:10 PM |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 23, 2013 | Sale | $7.42 | 33,448 | 248,134 | 5,071,550 | Jan 20, 2015, 06:10 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Sep 12, 2013 | Buy | $7.20 | 18,857 | 135,796 | 4,867,617 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 09, 2013 | Buy | $6.30 | 77,000 | 485,100 | 5,314,106 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 22, 2013 | Buy | $6.76 | 52,652 | 356,164 | 5,189,769 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 25, 2013 | Buy | $7.19 | 37,250 | 268,003 | 5,310,452 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Sep 11, 2013 | Buy | $7.19 | 38,800 | 279,069 | 4,867,617 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 02, 2013 | Buy | $6.98 | 23,100 | 161,319 | 5,314,106 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 21, 2013 | Buy | $6.69 | 23,100 | 154,590 | 5,208,557 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 28, 2013 | Buy | $6.39 | 38,500 | 245,823 | 4,906,117 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 22, 2013 | Buy | $7.20 | 63,283 | 455,837 | 5,365,873 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 27, 2013 | Buy | $6.49 | 77,000 | 499,345 | 4,983,117 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 29, 2013 | Buy | $6.90 | 17,894 | 123,501 | 5,328,623 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 20, 2013 | Buy | $6.75 | 38,500 | 259,844 | 5,237,106 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 26, 2013 | Buy | $6.58 | 154,000 | 1,012,742 | 5,137,117 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 17, 2013 | Buy | $7.09 | 38,400 | 272,387 | 5,365,873 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 25, 2013 | Sale | $7.18 | 55,421 | 398,089 | 5,287,794 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Sep 11, 2013 | Sale | $7.30 | 38,800 | 283,240 | 4,828,817 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 05, 2013 | Sale | $7.11 | 23,100 | 164,336 | 5,291,006 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 21, 2013 | Sale | $6.87 | 4,312 | 29,641 | 5,185,457 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 24, 2013 | Sale | $7.26 | 7,862 | 57,040 | 5,302,590 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 29, 2013 | Sale | $6.95 | 3,377 | 23,479 | 5,310,729 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 20, 2013 | Sale | $6.86 | 9,951 | 68,307 | 5,198,606 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 19, 2013 | Sale | $7.21 | 38,400 | 276,960 | 5,327,473 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner. See FN(1)(6) | Sep 12, 2013 | Sale | $7.26 | 18,857 | 136,996 | 4,848,760 | Jan 20, 2015, 06:09 PM |
| ACHN | Former 10% Owner, See FN(5)(6) | Sep 30, 2014 | Sale | $10.05 | 1,111,000 | 11,163,820 | 7,400,000 | Oct 01, 2014, 05:12 PM |
| ACHN | Former 10% Owner, See FN(5)(6) | Sep 29, 2014 | Sale | $10.96 | 221,014 | 2,423,264 | 7,811,000 | Oct 01, 2014, 05:12 PM |
| ACHN | 10% Owner | Sep 26, 2014 | Sale | $11.08 | 670,000 | 7,424,790 | 8,402,014 | Sep 26, 2014, 05:32 PM |
| ACHN | 10% Owner | Sep 25, 2014 | Sale | $11.05 | 497,986 | 5,501,745 | 9,083,814 | Sep 26, 2014, 05:32 PM |
| ACHN | 10% Owner | Sep 24, 2014 | Sale | $11.27 | 1,204,929 | 13,574,954 | 10,229,209 | Sep 26, 2014, 05:32 PM |
| ACHN | 10% Owner | Sep 23, 2014 | Sale | $11.08 | 984,522 | 10,909,010 | 11,377,668 | Sep 23, 2014, 04:58 PM |
| ACHN | 10% Owner | Sep 22, 2014 | Sale | $11.08 | 445,689 | 4,940,414 | 11,500,000 | Sep 23, 2014, 04:58 PM |
| ACHN | 10% Owner | Sep 19, 2014 | Sale | $11.55 | 1,164,860 | 13,450,957 | 12,672,287 | Sep 23, 2014, 04:58 PM |
| ACHN | 10% Owner | Sep 11, 2014 | Sale | $12.36 | 1,181,912 | 14,605,225 | 13,997,269 | Sep 12, 2014, 10:44 AM |
| ACHN | 10% Owner | Sep 10, 2014 | Sale | $12.67 | 522,450 | 6,619,270 | 14,695,762 | Sep 12, 2014, 10:44 AM |
| ACHN | 10% Owner | Sep 11, 2014 | Sale | $12.36 | 1,181,912 | 14,605,225 | 13,997,269 | Sep 12, 2014, 09:27 AM |
| ACHN | 10% Owner | Sep 10, 2014 | Sale | $66379.29 | 522,450 | 34,679,859,820 | 14,695,762 | Sep 12, 2014, 09:27 AM |
| ACHN | 10% Owner | Aug 29, 2014 | Sale | $11.41 | 398,845 | 4,551,768 | 15,361,864 | Sep 02, 2014, 05:14 PM |
| ACHN | 10% Owner | Aug 28, 2014 | Sale | $11.51 | 173,641 | 1,999,372 | 15,366,014 | Sep 02, 2014, 05:14 PM |
| ACHN | 10% Owner | Sep 02, 2014 | Sale | $12.03 | 262,807 | 3,160,329 | 14,966,069 | Sep 02, 2014, 05:14 PM |
| ACHN | 10% Owner | Aug 27, 2014 | Sale | $11.59 | 267,089 | 3,096,776 | 15,689,755 | Aug 27, 2014, 05:50 PM |
| ACHN | 10% Owner | Aug 26, 2014 | Sale | $11.35 | 2,112,867 | 23,981,550 | 16,571,972 | Aug 27, 2014, 05:50 PM |
| ACHN | 10% Owner | Aug 25, 2014 | Sale | $10.96 | 331,396 | 3,632,282 | 18,024,807 | Aug 27, 2014, 05:50 PM |
| ACHN | 10% Owner | Aug 15, 2014 | Sale | $9.40 | 2,241,022 | 21,069,424 | 21,805,285 | Aug 19, 2014, 05:05 PM |
| ACHN | 10% Owner | Aug 18, 2014 | Sale | $9.67 | 1,993,978 | 19,279,545 | 19,986,007 | Aug 19, 2014, 05:05 PM |
| ACHN | 10% Owner | Jun 20, 2014 | Sale | $8.40 | 880,000 | 7,390,400 | 22,566,007 | Jun 24, 2014, 04:28 PM |
| DRNA | 10% Owner | Feb 04, 2014 | Buy | $15.00 | 1,000,000 | 15,000,000 | 2,428,571 | Feb 05, 2014, 05:30 PM |
| DSCI | Fmr 10% Owner - See Fn (1)-(5) | Jan 10, 2014 | Sale | $11.83 | 300,000 | 3,549,500 | 1,884,876 | Jan 13, 2014, 04:50 PM |
| ACHN | 10% Owner | Nov 20, 2013 | Buy | $2.55 | 1,110,000 | 2,826,275 | 23,366,007 | Nov 22, 2013, 02:36 PM |
| ACHN | 10% Owner | Nov 12, 2013 | Buy | $2.48 | 1,795,000 | 4,451,600 | 22,256,007 | Nov 13, 2013, 02:51 PM |
| ACHN | 10% Owner | Oct 31, 2013 | Buy | $2.45 | 1,186,007 | 2,902,711 | 20,461,007 | Nov 01, 2013, 05:26 PM |
| ACHN | 10% Owner | Oct 14, 2013 | Buy | $2.79 | 2,369,229 | 6,615,933 | 19,275,000 | Oct 16, 2013, 09:35 AM |
| ACHN | 10% Owner | Oct 11, 2013 | Buy | $2.56 | 2,448,710 | 6,279,017 | 16,905,771 | Oct 15, 2013, 03:39 PM |
| ACHN | 10% Owner | Sep 30, 2013 | Buy | $2.98 | 2,800,000 | 8,354,089 | 14,457,061 | Oct 04, 2013, 04:18 PM |
| DSCI | 10% Owner | Apr 29, 2013 | Buy | $11.40 | 3,945 | 44,973 | 1,994,876 | May 01, 2013, 04:35 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| ANTX | 10% Owner | Jun 21, 2022 | Buy | 2,413 |
| WVE | Director | Jun 16, 2022 | Buy | 20,382,113 |
| ANTX | 10% Owner | Jun 14, 2022 | Buy | 489,402 |
| ANTX | 10% Owner | Jun 13, 2022 | Buy | 158,000 |
| KALA | 10% Owner | May 26, 2022 | Sale | 365,667 |
| KALA | 10% Owner | May 23, 2022 | Sale | 812,500 |
| KALA | 10% Owner | May 25, 2022 | Sale | 602,494 |
| KALA | 10% Owner | May 24, 2022 | Sale | 73,851 |
| PEPG | Director | May 10, 2022 | Buy | 38,750,400 |
| NKTX | Director | Apr 26, 2022 | Buy | 33,000,000 |
| ANTX | 10% Owner | Mar 29, 2022 | Buy | 24,999,990 |
| ICVX | Director | Mar 28, 2022 | Buy | 794,611 |
| ICVX | Director | Mar 29, 2022 | Buy | 42,271 |
| CTKB | Director | Mar 15, 2022 | Buy | 2,964,999 |
| CTKB | Director | Mar 14, 2022 | Buy | 4,223,926 |
| CTKB | Director | Mar 09, 2022 | Buy | 521,753 |
| CTKB | Director | Mar 11, 2022 | Buy | 4,309,334 |
| CTKB | Director | Mar 10, 2022 | Buy | 3,327,584 |
| CTKB | Director | Mar 08, 2022 | Buy | 3,160,059 |
| CTKB | Director | Mar 07, 2022 | Buy | 4,260,965 |
| CTKB | Director | Mar 04, 2022 | Buy | 827,230 |
| CTKB | Director | Feb 28, 2022 | Buy | 113,430 |
| CTKB | Director | Mar 02, 2022 | Buy | 1,782,218 |
| CTKB | Director | Mar 01, 2022 | Buy | 3,826,303 |
| CTKB | Director | Feb 25, 2022 | Buy | 246,699 |
| CTKB | Director | Feb 24, 2022 | Buy | 2,429,852 |
| CTKB | Director | Feb 23, 2022 | Buy | 2,883,114 |
| CTKB | Director | Feb 18, 2022 | Buy | 2,346,389 |
| CTKB | Director | Feb 17, 2022 | Buy | 2,457,264 |
| CTKB | Director | Feb 22, 2022 | Buy | 2,892,055 |
| CTKB | Director | Feb 16, 2022 | Buy | 2,489,377 |
| CTKB | Director | Feb 15, 2022 | Buy | 2,490,524 |
| CTKB | Director | Feb 14, 2022 | Buy | 2,446,924 |
| DICE | Director | Sep 17, 2021 | Buy | 23,800,000 |
| TYRA | Director | Sep 17, 2021 | Buy | 20,000,000 |
| ELYM | Director | Aug 12, 2021 | Buy | 40,000,000 |
| ICVX | Director | Aug 02, 2021 | Buy | 39,999,990 |
| CTKB | Director | Jul 27, 2021 | Buy | 50,150,000 |
| ABOS | Director | Jul 06, 2021 | Buy | 30,000,000 |
| AVTE | Director | Jul 02, 2021 | Buy | 38,999,996 |
| RACA | Director | Jun 29, 2021 | Buy | 2,091,000 |
| ETNB | Director | Jun 02, 2021 | Buy | 415,530 |
| HOWL | Director | May 04, 2021 | Buy | 27,440,000 |
| SLDB | Director | Mar 19, 2021 | Buy | 12,688,439 |
| SCPH | 10% Owner | Mar 15, 2021 | Sale | 777,787 |
| SCPH | 10% Owner | Mar 12, 2021 | Sale | 284,816 |
| PHAT | 10% Owner | Mar 11, 2021 | Sale | 31,062,500 |
| STSA | Director | Feb 26, 2021 | Buy | 6,999,998 |
| VOR | Director | Feb 09, 2021 | Buy | 53,632,188 |
| RYTM | Former 10% Owner | Dec 03, 2020 | Sale | 6,027,391 |
| RYTM | Former 10% Owner | Dec 02, 2020 | Sale | 1,002,261 |
| ORTX | 10% Owner | Aug 18, 2020 | Buy | 213,575 |
| ORTX | 10% Owner | Aug 17, 2020 | Buy | 39,034 |
| ORTX | 10% Owner | Sep 24, 2020 | Buy | 2,182,038 |
| ORTX | 10% Owner | Aug 14, 2020 | Buy | 61,767 |
| ORTX | 10% Owner | Aug 21, 2020 | Buy | 298,609 |
| ORTX | 10% Owner | Aug 12, 2020 | Buy | 77,219 |
| ORTX | 10% Owner | Aug 20, 2020 | Buy | 288,729 |
| ORTX | 10% Owner | Aug 10, 2020 | Buy | 101,174 |
| ORTX | 10% Owner | Aug 19, 2020 | Buy | 300,989 |
| PCVX | 10% Owner | Oct 08, 2020 | Sale | 8,498,066 |
| PCVX | 10% Owner | Oct 07, 2020 | Sale | 5,023,527 |
| PCVX | 10% Owner | Oct 01, 2020 | Sale | 776,705 |
| PCVX | 10% Owner | Sep 30, 2020 | Sale | 6,265,871 |
| PCVX | 10% Owner | Sep 29, 2020 | Sale | 4,202,986 |
| PMVP | 10% Owner | Sep 29, 2020 | Buy | 17,100,000 |
| DYN | 10% Owner | Sep 21, 2020 | Buy | 12,540,000 |
| ETNB | Director | Sep 17, 2020 | Buy | 36,400,000 |
| TGTX | 10% Owner | Sep 09, 2020 | Sale | 4,092,738 |
| ITOS | 10% Owner | Jul 28, 2020 | Buy | 27,075,000 |
| INZY | 10% Owner | Jul 28, 2020 | Buy | 9,600,000 |
| PAND | 10% Owner | Jul 21, 2020 | Buy | 6,499,998 |
| NKTX | 10% Owner | Jul 14, 2020 | Buy | 59,999,994 |
| ETNB | Director | Jul 08, 2020 | Buy | 7,562,500 |
| RYTM | 10% Owner | Jul 01, 2020 | Sale | 558,311 |
| RYTM | 10% Owner | Jun 30, 2020 | Sale | 1,371,237 |
| RYTM | 10% Owner | Jul 02, 2020 | Sale | 972,969 |
| AKUS | 10% Owner | Jun 30, 2020 | Buy | 14,025,000 |
| RYTM | 10% Owner | Jun 29, 2020 | Sale | 1,154,999 |
| RYTM | 10% Owner | Jun 26, 2020 | Sale | 2,020,848 |
| RYTM | 10% Owner | Jun 25, 2020 | Sale | 289,768 |
| VSTM | 10% Owner | Jun 25, 2020 | Sale | 2,219,941 |
| FMTX | 10% Owner | Jun 23, 2020 | Buy | 80,000,000 |
| VSTM | 10% Owner | Apr 27, 2020 | Sale | 3,002,099 |
| PHAT | 10% Owner | Apr 01, 2020 | Buy | 2,923,642 |
| RARX | Director | Apr 02, 2020 | Option Exercise | 233,196,480 |
| PHAT | 10% Owner | Mar 27, 2020 | Buy | 738,000 |
| PHAT | 10% Owner | Mar 31, 2020 | Buy | 751,264 |
| IMRA | 10% Owner | Mar 16, 2020 | Buy | 10,000,000 |
| KALA | Director | Mar 13, 2020 | Buy | 49,999,994 |
| SCPH | 10% Owner | Feb 14, 2020 | Buy | 2,230,343 |
| SCPH | 10% Owner | Feb 14, 2020 | Buy | 2,230,343 |
| THOR | 10% Owner | Jan 23, 2020 | Option Exercise | 661,272,664 |
| THOR | 10% Owner | Jan 23, 2020 | Option Exercise | 661,272,664 |
| ETNB | Director | Nov 11, 2019 | Buy | 24,000,000 |
| STSA | Director | Sep 17, 2019 | Buy | 19,999,995 |
| SCPH | 10% Owner | Apr 11, 2019 | Buy | 1,052,627 |
| WVE | Director | Jan 24, 2019 | Buy | 10,000,004 |
| RARX | Director | Dec 12, 2018 | Buy | 15,600,006 |
| THOR | 10% Owner | Dec 11, 2018 | Buy | 50,000,005 |
| KALA | Director | Oct 03, 2018 | Buy | 19,999,997 |
| ARVN | Former 10% Owner | Oct 01, 2018 | Buy | 16,000,000 |
| EIDX | Director | Jun 22, 2018 | Buy | 18,000,008 |
| RARX | Director | Feb 14, 2018 | Buy | 15,000,000 |
| WVE | Director | Nov 14, 2017 | Buy | 561,550 |
| WVE | Director | Nov 13, 2017 | Buy | 9,320,000 |
| KALV | Director | Oct 12, 2017 | Buy | 7,225,000 |
| KALA | Director | Jul 25, 2017 | Buy | 7,999,995 |
| GTHX | Fmr 10% Owner See Footnote (2) | May 22, 2017 | Buy | 6,000,000 |
| RARX | Director | Oct 31, 2016 | Buy | 2,099,994 |
| ACRS | 10% Owner | Sep 16, 2016 | Sale | 4,254,212 |
| ACRS | 10% Owner | Sep 15, 2016 | Sale | 8,459,290 |
| ACRS | 10% Owner | Feb 22, 2016 | Buy | 180,958 |
| ACRS | 10% Owner | Feb 23, 2016 | Buy | 500,512 |
| ACRS | 10% Owner | Jan 20, 2016 | Buy | 35,849 |
| ACRS | 10% Owner | Jan 19, 2016 | Buy | 83,480 |
| ACRS | 10% Owner | Jan 15, 2016 | Buy | 35,743 |
| ACRS | 10% Owner | Jan 11, 2016 | Buy | 74,479 |
| ACRS | 10% Owner | Jan 13, 2016 | Buy | 110,674 |
| ACRS | 10% Owner | Jan 12, 2016 | Buy | 113,585 |
| WVE | Director | Nov 16, 2015 | Buy | 30,000,000 |
| ACRS | 10% Owner | Oct 29, 2015 | Buy | 1,330,000 |
| ACRS | 10% Owner | Oct 28, 2015 | Buy | 2,088,800 |
| ACRS | 10% Owner | Oct 22, 2015 | Buy | 75,883 |
| ACRS | 10% Owner | Oct 19, 2015 | Buy | 356,049 |
| ACRS | 10% Owner | Oct 21, 2015 | Buy | 45,976 |
| ACRS | 10% Owner | Oct 20, 2015 | Buy | 119,070 |
| ACRS | 10% Owner | Oct 14, 2015 | Buy | 601,792 |
| ACRS | 10% Owner | Oct 08, 2015 | Buy | 238,555 |
| ACRS | 10% Owner | Oct 07, 2015 | Buy | 24,051,364 |
| SGMO | Former 10% Owner | Jul 17, 2014 | Buy | 456,211 |
| SGMO | Former 10% Owner | Jul 01, 2014 | Sale | 1,323,999 |
| SGMO | Former 10% Owner | Jul 29, 2014 | Sale | 17,464 |
| SGMO | Former 10% Owner | Jun 16, 2014 | Sale | 4,146,531 |
| SGMO | Former 10% Owner | Jul 28, 2014 | Sale | 727,474 |
| SGMO | Former 10% Owner | Jun 09, 2014 | Sale | 1,294,159 |
| SGMO | Former 10% Owner | Jul 25, 2014 | Sale | 583,951 |
| SGMO | Former 10% Owner | Jun 06, 2014 | Sale | 1,930,949 |
| SGMO | Former 10% Owner | Jul 24, 2014 | Sale | 1,523,235 |
| SGMO | Former 10% Owner | Aug 01, 2014 | Sale | 356,100 |
| SGMO | Former 10% Owner | Jun 05, 2014 | Sale | 1,626,669 |
| SGMO | Former 10% Owner | Jul 30, 2014 | Sale | 1,361,606 |
| SGMO | Former 10% Owner | May 07, 2014 | Buy | 431,870 |
| SGMO | Former 10% Owner | Jun 05, 2014 | Sale | 12,669,888 |
| SGMO | Former 10% Owner | May 08, 2014 | Sale | 1,032,587 |
| SGMO | Former 10% Owner | May 27, 2014 | Sale | 3,570,473 |
| SGMO | Former 10% Owner | Jun 04, 2014 | Sale | 925,227 |
| SGMO | Former 10% Owner | May 23, 2014 | Sale | 684,713 |
| SGMO | Former 10% Owner | Jun 03, 2014 | Sale | 988,072 |
| SGMO | Former 10% Owner | May 22, 2014 | Sale | 764,537 |
| SGMO | Former 10% Owner | May 30, 2014 | Sale | 883,147 |
| SGMO | Former 10% Owner | May 13, 2014 | Sale | 735,305 |
| SGMO | Former 10% Owner | May 29, 2014 | Sale | 2,106,559 |
| SGMO | Former 10% Owner | May 12, 2014 | Sale | 386,330 |
| SGMO | Former 10% Owner | May 28, 2014 | Sale | 1,996,952 |
| SGMO | Former 10% Owner | Apr 25, 2014 | Buy | 2,262,779 |
| SGMO | Former 10% Owner | Apr 07, 2014 | Buy | 519,310 |
| SGMO | Former 10% Owner | Apr 11, 2014 | Buy | 1,694,299 |
| SGMO | Former 10% Owner | Apr 04, 2014 | Buy | 2,753,712 |
| SGMO | Former 10% Owner | Apr 17, 2014 | Buy | 581,959 |
| SGMO | Former 10% Owner | May 07, 2014 | Buy | 557,989 |
| SGMO | Former 10% Owner | Apr 03, 2014 | Buy | 3,241,999 |
| SGMO | Former 10% Owner | Apr 10, 2014 | Buy | 1,237,339 |
| SGMO | Former 10% Owner | Apr 30, 2014 | Buy | 1,674,679 |
| SGMO | Former 10% Owner | Apr 15, 2014 | Buy | 287,206 |
| SGMO | Former 10% Owner | Apr 28, 2014 | Buy | 995,014 |
| SGMO | Former 10% Owner | Apr 08, 2014 | Buy | 1,888,274 |
| SGMO | Former 10% Owner | Apr 22, 2014 | Sale | 5,243,538 |
| SGMO | Former 10% Owner | Apr 10, 2014 | Sale | 53,326 |
| SGMO | Former 10% Owner | Apr 16, 2014 | Sale | 307,658 |
| SGMO | Former 10% Owner | Apr 09, 2014 | Sale | 1,136,424 |
| SGMO | Former 10% Owner | Apr 14, 2014 | Sale | 45,165 |
| SGMO | Former 10% Owner | Mar 27, 2014 | Buy | 4,522,356 |
| SGMO | Former 10% Owner | Mar 17, 2014 | Buy | 1,200,835 |
| SGMO | Former 10% Owner | Mar 26, 2014 | Buy | 3,808,711 |
| SGMO | Former 10% Owner | Mar 13, 2014 | Buy | 1,623,356 |
| SGMO | Former 10% Owner | Mar 25, 2014 | Buy | 1,631,041 |
| SGMO | Former 10% Owner | Mar 21, 2014 | Buy | 2,159,989 |
| SGMO | Former 10% Owner | Mar 10, 2014 | Buy | 279,180 |
| SGMO | Former 10% Owner | Mar 28, 2014 | Buy | 1,436,056 |
| SGMO | Former 10% Owner | Mar 07, 2014 | Buy | 5,748,552 |
| SGMO | Former 10% Owner | Mar 06, 2014 | Sale | 1,481,538 |
| SGMO | Former 10% Owner | Mar 12, 2014 | Sale | 2,889,432 |
| SGMO | Former 10% Owner | Apr 01, 2014 | Sale | 4,502,381 |
| SGMO | Former 10% Owner | Mar 19, 2014 | Sale | 432,432 |
| SGMO | Former 10% Owner | Mar 18, 2014 | Sale | 1,994,573 |
| SGMO | Former 10% Owner | Feb 05, 2014 | Buy | 765,828 |
| SGMO | Former 10% Owner | Feb 26, 2014 | Buy | 1,452,243 |
| SGMO | Former 10% Owner | Feb 12, 2014 | Buy | 757,621 |
| SGMO | Former 10% Owner | Mar 06, 2014 | Buy | 1,890,245 |
| SGMO | Former 10% Owner | Feb 11, 2014 | Buy | 825,275 |
| SGMO | Former 10% Owner | Feb 28, 2014 | Buy | 760,145 |
| SGMO | Former 10% Owner | Feb 27, 2014 | Sale | 623,499 |
| SGMO | Former 10% Owner | Feb 13, 2014 | Sale | 284,438 |
| SGMO | Former 10% Owner | Mar 06, 2014 | Sale | 6,831,412 |
| SGMO | Former 10% Owner | Feb 20, 2014 | Sale | 649,869 |
| SGMO | Former 10% Owner | Feb 19, 2014 | Sale | 124,420 |
| SGMO | Former 10% Owner | Mar 03, 2014 | Sale | 1,529,902 |
| SGMO | Former 10% Owner | Feb 07, 2014 | Sale | 642,432 |
| SGMO | Former 10% Owner | Feb 18, 2014 | Sale | 202,278 |
| SGMO | Former 10% Owner | Feb 06, 2014 | Sale | 134,683 |
| SGMO | Former 10% Owner | Feb 14, 2014 | Sale | 286,166 |
| SGMO | Former 10% Owner. | Dec 13, 2013 | Buy | 60,921 |
| SGMO | Former 10% Owner. | Dec 12, 2013 | Buy | 116,071 |
| SGMO | Former 10% Owner. | Jan 09, 2014 | Sale | 1,329,365 |
| SGMO | Former 10% Owner | Jul 17, 2013 | Buy | 187,895 |
| SGMO | Former 10% Owner | Jul 23, 2013 | Sale | 46,938 |
| SGMO | Former 10% Owner | Jul 22, 2013 | Sale | 1,065,610 |
| SGMO | Former 10% Owner | Jul 19, 2013 | Sale | 2,065,714 |
| SGMO | Former 10% Owner | Jul 18, 2013 | Sale | 741,498 |
| SGMO | Former 10% Owner | Jul 17, 2013 | Sale | 493,401 |
| SGMO | Former 10% Owner | Jul 25, 2013 | Sale | 3,582,848 |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 30, 2013 | Buy | 5,432,000 |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 27, 2013 | Buy | 2,400,000 |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 20, 2013 | Sale | 196,481 |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 18, 2013 | Sale | 17,413 |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 17, 2013 | Sale | 575,994 |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 25, 2013 | Sale | 985,908 |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 16, 2013 | Sale | 690,913 |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 24, 2013 | Sale | 1,330,789 |
| ACHN | Former 10% Owner. See FN(1)(2) | Sep 23, 2013 | Sale | 248,134 |
| ACHN | Former 10% Owner. See FN(1)(6) | Sep 12, 2013 | Buy | 135,796 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 09, 2013 | Buy | 485,100 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 22, 2013 | Buy | 356,164 |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 25, 2013 | Buy | 268,003 |
| ACHN | Former 10% Owner. See FN(1)(6) | Sep 11, 2013 | Buy | 279,069 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 02, 2013 | Buy | 161,319 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 21, 2013 | Buy | 154,590 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 28, 2013 | Buy | 245,823 |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 22, 2013 | Buy | 455,837 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 27, 2013 | Buy | 499,345 |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 29, 2013 | Buy | 123,501 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 20, 2013 | Buy | 259,844 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 26, 2013 | Buy | 1,012,742 |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 17, 2013 | Buy | 272,387 |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 25, 2013 | Sale | 398,089 |
| ACHN | Former 10% Owner. See FN(1)(6) | Sep 11, 2013 | Sale | 283,240 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 05, 2013 | Sale | 164,336 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 21, 2013 | Sale | 29,641 |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 24, 2013 | Sale | 57,040 |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 29, 2013 | Sale | 23,479 |
| ACHN | Former 10% Owner. See FN(1)(6) | Aug 20, 2013 | Sale | 68,307 |
| ACHN | Former 10% Owner. See FN(1)(6) | Jul 19, 2013 | Sale | 276,960 |
| ACHN | Former 10% Owner. See FN(1)(6) | Sep 12, 2013 | Sale | 136,996 |
| ACHN | Former 10% Owner, See FN(5)(6) | Sep 30, 2014 | Sale | 11,163,820 |
| ACHN | Former 10% Owner, See FN(5)(6) | Sep 29, 2014 | Sale | 2,423,264 |
| ACHN | 10% Owner | Sep 26, 2014 | Sale | 7,424,790 |
| ACHN | 10% Owner | Sep 25, 2014 | Sale | 5,501,745 |
| ACHN | 10% Owner | Sep 24, 2014 | Sale | 13,574,954 |
| ACHN | 10% Owner | Sep 23, 2014 | Sale | 10,909,010 |
| ACHN | 10% Owner | Sep 22, 2014 | Sale | 4,940,414 |
| ACHN | 10% Owner | Sep 19, 2014 | Sale | 13,450,957 |
| ACHN | 10% Owner | Sep 11, 2014 | Sale | 14,605,225 |
| ACHN | 10% Owner | Sep 10, 2014 | Sale | 6,619,270 |
| ACHN | 10% Owner | Sep 11, 2014 | Sale | 14,605,225 |
| ACHN | 10% Owner | Sep 10, 2014 | Sale | 34,679,859,820 |
| ACHN | 10% Owner | Aug 29, 2014 | Sale | 4,551,768 |
| ACHN | 10% Owner | Aug 28, 2014 | Sale | 1,999,372 |
| ACHN | 10% Owner | Sep 02, 2014 | Sale | 3,160,329 |
| ACHN | 10% Owner | Aug 27, 2014 | Sale | 3,096,776 |
| ACHN | 10% Owner | Aug 26, 2014 | Sale | 23,981,550 |
| ACHN | 10% Owner | Aug 25, 2014 | Sale | 3,632,282 |
| ACHN | 10% Owner | Aug 15, 2014 | Sale | 21,069,424 |
| ACHN | 10% Owner | Aug 18, 2014 | Sale | 19,279,545 |
| ACHN | 10% Owner | Jun 20, 2014 | Sale | 7,390,400 |
| DRNA | 10% Owner | Feb 04, 2014 | Buy | 15,000,000 |
| DSCI | Fmr 10% Owner - See Fn (1)-(5) | Jan 10, 2014 | Sale | 3,549,500 |
| ACHN | 10% Owner | Nov 20, 2013 | Buy | 2,826,275 |
| ACHN | 10% Owner | Nov 12, 2013 | Buy | 4,451,600 |
| ACHN | 10% Owner | Oct 31, 2013 | Buy | 2,902,711 |
| ACHN | 10% Owner | Oct 14, 2013 | Buy | 6,615,933 |
| ACHN | 10% Owner | Oct 11, 2013 | Buy | 6,279,017 |
| ACHN | 10% Owner | Sep 30, 2013 | Buy | 8,354,089 |
| DSCI | 10% Owner | Apr 29, 2013 | Buy | 44,973 |