| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| NKTR | SVP & Chief Medical Officer | Nov 16, 2017 | Option Exercise | $44.23 | 5,022 | 222,123 | 56,553 | Nov 17, 2017, 06:03 PM |
| NKTR | SVP & Chief Medical Officer | Oct 02, 2017 | Option Exercise | $11.04 | 56,704 | 626,012 | 98,279 | Oct 03, 2017, 06:02 PM |
| NKTR | SVP & Chief Medical Officer | Sep 29, 2017 | Option Exercise | $11.04 | 43,296 | 477,988 | 84,871 | Oct 03, 2017, 06:02 PM |
| NKTR | SVP & Chief Medical Officer | Sep 29, 2017 | Sale | $24.04 | 43,296 | 1,040,836 | 41,575 | Oct 03, 2017, 06:02 PM |
| NKTR | SVP & Chief Medical Officer | Oct 02, 2017 | Sale | $24.21 | 56,704 | 1,372,804 | 41,575 | Oct 03, 2017, 06:02 PM |
| NKTR | SVP & Chief Medical Officer | Aug 16, 2017 | Sale | $19.32 | 1,997 | 38,582 | 41,575 | Aug 18, 2017, 07:02 PM |
| NKTR | SVP & Chief Medical Officer | Jul 18, 2017 | Option Exercise | $11.04 | 54,920 | 606,317 | 98,492 | Jul 20, 2017, 05:08 PM |
| NKTR | SVP & Chief Medical Officer | Jul 18, 2017 | Sale | $21.10 | 54,920 | 1,158,812 | 43,572 | Jul 20, 2017, 05:08 PM |
| NKTR | SVP & Chief Medical Officer | Jul 12, 2017 | Option Exercise | $11.04 | 36,691 | 405,069 | 80,263 | Jul 13, 2017, 08:01 PM |
| NKTR | SVP & Chief Medical Officer | Jul 11, 2017 | Option Exercise | $11.04 | 8,389 | 92,615 | 51,961 | Jul 13, 2017, 08:01 PM |
| NKTR | SVP & Chief Medical Officer | Jul 12, 2017 | Sale | $21.09 | 36,691 | 773,813 | 43,572 | Jul 13, 2017, 08:01 PM |
| NKTR | SVP & Chief Medical Officer | Jul 11, 2017 | Sale | $21.04 | 8,389 | 176,505 | 43,572 | Jul 13, 2017, 08:01 PM |
| NKTR | SVP & Chief Medical Officer | May 16, 2017 | Sale | $19.55 | 1,450 | 28,347 | 43,572 | May 18, 2017, 08:46 PM |
| NKTR | SVP & Chief Medical Officer | Feb 16, 2017 | Sale | $13.14 | 1,457 | 19,145 | 45,022 | Feb 17, 2017, 08:03 PM |
| NKTR | SVP & Chief Medical Officer | Nov 16, 2016 | Sale | $13.96 | 848 | 11,838 | 26,479 | Nov 18, 2016, 06:08 PM |
| NKTR | SVP & Chief Medical Officer | Aug 16, 2016 | Sale | $17.56 | 1,685 | 29,589 | 27,327 | Aug 17, 2016, 05:38 PM |
| NKTR | SVP & Chief Medical Officer | May 16, 2016 | Option Exercise | $0.00 | 1,250 | 0 | 1,944 | May 18, 2016, 05:14 PM |
| NKTR | SVP & Chief Medical Officer | May 17, 2016 | Sale | $13.58 | 432 | 5,867 | 1,512 | May 18, 2016, 05:14 PM |
| NKTR | SVP & Chief Medical Officer | Feb 16, 2016 | Option Exercise | $0.00 | 1,250 | 0 | 1,250 | Feb 18, 2016, 07:49 PM |
| NKTR | SVP & Chief Medical Officer | Feb 17, 2016 | Sale | $11.92 | 556 | 6,628 | 694 | Feb 18, 2016, 07:49 PM |
| ENDP | EVP, R&D and CSO | Mar 10, 2014 | Option Exercise | $31.13 | 75,637 | 2,354,595 | 58,811 | Mar 11, 2014, 08:18 PM |
| ENDP | EVP, R&D and CSO | Mar 10, 2014 | Sale | $72.47 | 75,637 | 5,481,413 | 27,649 | Mar 11, 2014, 08:18 PM |
| ENDP | EVP, R&D and CSO | Feb 27, 2014 | Option Exercise | $79.82 | 909 | 72,556 | 27,649 | Feb 28, 2014, 04:24 PM |
| ENDP | EVP, R&D and CSO | Feb 26, 2014 | Option Exercise | $78.30 | 9,105 | 712,922 | 26,564 | Feb 28, 2014, 04:24 PM |
| ENDP | EVP, R&D and CSO | Feb 23, 2014 | Option Exercise | $77.26 | 1,517 | 117,203 | 15,695 | Feb 25, 2014, 04:04 PM |
| ENDP | EVP, R&D and CSO | Feb 22, 2014 | Option Exercise | $77.26 | 1,531 | 118,285 | 13,883 | Feb 25, 2014, 04:04 PM |
| ENDP | EVP, R&D and CSO | Feb 19, 2014 | Option Exercise | $75.22 | 10,127 | 761,753 | 12,054 | Feb 21, 2014, 04:02 PM |
| ENDP | EVP, R&D and CSO | Apr 24, 2013 | Option Exercise | $20.74 | 105,190 | 2,181,471 | 94,241 | Apr 26, 2013, 04:02 PM |
| ENDP | EVP, R&D and CSO | Apr 24, 2013 | Sale | $36.45 | 138,225 | 5,038,911 | 33,035 | Apr 26, 2013, 04:02 PM |
| ENDP | EVP, Research & Development | Feb 27, 2013 | Option Exercise | $30.03 | 7,168 | 215,255 | 8,556 | Feb 28, 2013, 09:21 PM |
| ENDP | EVP, Research & Development | Feb 26, 2013 | Option Exercise | $28.09 | 3,082 | 86,573 | 1,820 | Feb 28, 2013, 09:21 PM |
| ENDP | EVP, Research & Development | Dec 31, 2012 | Option Exercise | $25.89 | 14,705 | 380,712 | 18,566 | Jan 03, 2013, 09:29 PM |
| ENDP | EVP, Research & Development | Feb 23, 2012 | Option Exercise | $34.79 | 1,024 | 35,625 | 2,305 | Feb 24, 2012, 05:20 PM |
| ENDP | EVP, Research & Development | May 03, 2011 | Option Exercise | $25.02 | 12,500 | 312,750 | 12,500 | May 04, 2011, 05:11 PM |
| ENDP | EVP, Research & Development | May 03, 2011 | Sale | $39.39 | 12,500 | 492,375 | 0 | May 04, 2011, 05:11 PM |
| ENDP | EVP, Research & Development | Feb 28, 2011 | Option Exercise | $19.93 | 30,603 | 609,918 | 30,603 | Mar 03, 2011, 05:44 PM |
| ENDP | EVP, Research & Development | Mar 02, 2011 | Sale | $35.77 | 30,603 | 1,094,669 | 0 | Mar 03, 2011, 05:44 PM |
| ENDP | EVP, Research & Development | Feb 24, 2011 | Option Exercise | $20.61 | 15,742 | 324,443 | 15,742 | Feb 25, 2011, 06:40 PM |
| ENDP | EVP, Research & Development | Feb 24, 2011 | Sale | $33.59 | 15,742 | 528,774 | 0 | Feb 25, 2011, 06:40 PM |
| ENDP | EVP, Research & Development | Dec 03, 2010 | Option Exercise | $22.22 | 55,603 | 1,235,418 | 55,603 | Dec 07, 2010, 04:52 PM |
| ENDP | EVP, Research & Development | Dec 03, 2010 | Sale | $36.53 | 55,603 | 2,031,178 | 30,603 | Dec 07, 2010, 04:52 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| NKTR | SVP & Chief Medical Officer | Nov 16, 2017 | Option Exercise | 222,123 |
| NKTR | SVP & Chief Medical Officer | Oct 02, 2017 | Option Exercise | 626,012 |
| NKTR | SVP & Chief Medical Officer | Sep 29, 2017 | Option Exercise | 477,988 |
| NKTR | SVP & Chief Medical Officer | Sep 29, 2017 | Sale | 1,040,836 |
| NKTR | SVP & Chief Medical Officer | Oct 02, 2017 | Sale | 1,372,804 |
| NKTR | SVP & Chief Medical Officer | Aug 16, 2017 | Sale | 38,582 |
| NKTR | SVP & Chief Medical Officer | Jul 18, 2017 | Option Exercise | 606,317 |
| NKTR | SVP & Chief Medical Officer | Jul 18, 2017 | Sale | 1,158,812 |
| NKTR | SVP & Chief Medical Officer | Jul 12, 2017 | Option Exercise | 405,069 |
| NKTR | SVP & Chief Medical Officer | Jul 11, 2017 | Option Exercise | 92,615 |
| NKTR | SVP & Chief Medical Officer | Jul 12, 2017 | Sale | 773,813 |
| NKTR | SVP & Chief Medical Officer | Jul 11, 2017 | Sale | 176,505 |
| NKTR | SVP & Chief Medical Officer | May 16, 2017 | Sale | 28,347 |
| NKTR | SVP & Chief Medical Officer | Feb 16, 2017 | Sale | 19,145 |
| NKTR | SVP & Chief Medical Officer | Nov 16, 2016 | Sale | 11,838 |
| NKTR | SVP & Chief Medical Officer | Aug 16, 2016 | Sale | 29,589 |
| NKTR | SVP & Chief Medical Officer | May 16, 2016 | Option Exercise | 0 |
| NKTR | SVP & Chief Medical Officer | May 17, 2016 | Sale | 5,867 |
| NKTR | SVP & Chief Medical Officer | Feb 16, 2016 | Option Exercise | 0 |
| NKTR | SVP & Chief Medical Officer | Feb 17, 2016 | Sale | 6,628 |
| ENDP | EVP, R&D and CSO | Mar 10, 2014 | Option Exercise | 2,354,595 |
| ENDP | EVP, R&D and CSO | Mar 10, 2014 | Sale | 5,481,413 |
| ENDP | EVP, R&D and CSO | Feb 27, 2014 | Option Exercise | 72,556 |
| ENDP | EVP, R&D and CSO | Feb 26, 2014 | Option Exercise | 712,922 |
| ENDP | EVP, R&D and CSO | Feb 23, 2014 | Option Exercise | 117,203 |
| ENDP | EVP, R&D and CSO | Feb 22, 2014 | Option Exercise | 118,285 |
| ENDP | EVP, R&D and CSO | Feb 19, 2014 | Option Exercise | 761,753 |
| ENDP | EVP, R&D and CSO | Apr 24, 2013 | Option Exercise | 2,181,471 |
| ENDP | EVP, R&D and CSO | Apr 24, 2013 | Sale | 5,038,911 |
| ENDP | EVP, Research & Development | Feb 27, 2013 | Option Exercise | 215,255 |
| ENDP | EVP, Research & Development | Feb 26, 2013 | Option Exercise | 86,573 |
| ENDP | EVP, Research & Development | Dec 31, 2012 | Option Exercise | 380,712 |
| ENDP | EVP, Research & Development | Feb 23, 2012 | Option Exercise | 35,625 |
| ENDP | EVP, Research & Development | May 03, 2011 | Option Exercise | 312,750 |
| ENDP | EVP, Research & Development | May 03, 2011 | Sale | 492,375 |
| ENDP | EVP, Research & Development | Feb 28, 2011 | Option Exercise | 609,918 |
| ENDP | EVP, Research & Development | Mar 02, 2011 | Sale | 1,094,669 |
| ENDP | EVP, Research & Development | Feb 24, 2011 | Option Exercise | 324,443 |
| ENDP | EVP, Research & Development | Feb 24, 2011 | Sale | 528,774 |
| ENDP | EVP, Research & Development | Dec 03, 2010 | Option Exercise | 1,235,418 |
| ENDP | EVP, Research & Development | Dec 03, 2010 | Sale | 2,031,178 |