| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| ADVM | Director | Mar 24, 2021 | Buy | $9.92 | 10,000 | 99,196 | 88,182 | Mar 24, 2021, 07:46 PM |
| ADVM | Director | Jan 15, 2021 | Buy | $11.52 | 10,000 | 115,174 | 78,182 | Jan 19, 2021, 08:33 PM |
| UROV | 10% Owner | Jun 19, 2019 | Buy | $8.17 | 4,957 | 40,495 | 22,860,013 | Jun 19, 2019, 06:30 PM |
| UROV | 10% Owner | Jun 18, 2019 | Buy | $8.21 | 6,706 | 55,061 | 22,855,056 | Jun 19, 2019, 06:30 PM |
| UROV | 10% Owner | Jun 17, 2019 | Buy | $8.53 | 6,541 | 55,825 | 22,848,350 | Jun 19, 2019, 06:30 PM |
| UROV | 10% Owner | Jun 14, 2019 | Buy | $7.91 | 7,144 | 56,514 | 22,841,809 | Jun 14, 2019, 06:15 PM |
| UROV | 10% Owner | Jun 13, 2019 | Buy | $7.95 | 7,367 | 58,543 | 22,834,665 | Jun 14, 2019, 06:15 PM |
| UROV | 10% Owner | Jun 12, 2019 | Buy | $8.30 | 7,500 | 62,244 | 22,827,298 | Jun 14, 2019, 06:15 PM |
| UROV | 10% Owner | Jun 11, 2019 | Buy | $8.58 | 7,189 | 61,694 | 22,819,798 | Jun 11, 2019, 06:31 PM |
| UROV | 10% Owner | Jun 10, 2019 | Buy | $8.35 | 7,500 | 62,594 | 22,812,609 | Jun 11, 2019, 06:31 PM |
| UROV | 10% Owner | Jun 07, 2019 | Buy | $7.97 | 6,649 | 52,959 | 22,805,109 | Jun 11, 2019, 06:31 PM |
| MYOV | 10% Owner | Jun 04, 2019 | Buy | $8.25 | 2,424,242 | 19,999,997 | 40,765,599 | Jun 06, 2019, 06:30 PM |
| UROV | 10% Owner | Jun 06, 2019 | Buy | $8.00 | 7,082 | 56,621 | 22,798,460 | Jun 06, 2019, 06:01 PM |
| UROV | 10% Owner | Jun 05, 2019 | Buy | $8.02 | 6,540 | 52,418 | 22,791,378 | Jun 06, 2019, 06:01 PM |
| UROV | 10% Owner | Jun 04, 2019 | Buy | $7.59 | 7,500 | 56,911 | 22,784,838 | Jun 06, 2019, 06:01 PM |
| UROV | 10% Owner | May 31, 2019 | Buy | $7.70 | 5,071 | 39,042 | 22,771,914 | Jun 03, 2019, 07:17 PM |
| UROV | 10% Owner | May 30, 2019 | Buy | $8.01 | 7,251 | 58,090 | 22,766,843 | Jun 03, 2019, 07:17 PM |
| UROV | 10% Owner | Jun 03, 2019 | Buy | $7.71 | 5,424 | 41,815 | 22,777,338 | Jun 03, 2019, 07:17 PM |
| UROV | 10% Owner | May 29, 2019 | Buy | $7.55 | 6,882 | 51,983 | 22,759,592 | May 29, 2019, 06:33 PM |
| UROV | 10% Owner | May 28, 2019 | Buy | $7.68 | 3,807 | 29,245 | 22,752,710 | May 29, 2019, 06:33 PM |
| UROV | 10% Owner | May 24, 2019 | Buy | $7.70 | 3,796 | 29,233 | 22,748,903 | May 29, 2019, 06:33 PM |
| UROV | 10% Owner | May 23, 2019 | Buy | $7.76 | 4,802 | 37,252 | 22,745,107 | May 23, 2019, 06:30 PM |
| UROV | 10% Owner | May 22, 2019 | Buy | $8.06 | 5,033 | 40,558 | 22,740,305 | May 23, 2019, 06:30 PM |
| UROV | 10% Owner | May 21, 2019 | Buy | $8.52 | 9,995 | 85,108 | 22,735,272 | May 23, 2019, 06:30 PM |
| UROV | 10% Owner | May 20, 2019 | Buy | $8.05 | 10,000 | 80,525 | 22,725,277 | May 20, 2019, 06:30 PM |
| UROV | 10% Owner | May 17, 2019 | Buy | $7.36 | 6,200 | 45,641 | 22,715,277 | May 20, 2019, 06:30 PM |
| UROV | 10% Owner | May 16, 2019 | Buy | $6.79 | 5,408 | 36,718 | 22,709,077 | May 20, 2019, 06:30 PM |
| AXON | 10% Owner | Mar 18, 2019 | Buy | $1.50 | 6,666,667 | 10,000,001 | 105,952,381 | Mar 19, 2019, 05:03 PM |
| ECYT | Director | Dec 21, 2018 | Option Exercise | $24.00 | 7,050 | 169,200 | 0 | Dec 21, 2018, 12:54 PM |
| AXON | 10% Owner | Dec 18, 2018 | Buy | $1.00 | 10,000,000 | 10,000,000 | 99,285,714 | Dec 20, 2018, 06:03 AM |
| UROV | 10% Owner | Oct 01, 2018 | Buy | $14.00 | 2,678,571 | 37,499,994 | 22,703,669 | Oct 03, 2018, 04:49 PM |
| AXON | 10% Owner | Jun 05, 2018 | Buy | $1.75 | 14,285,714 | 25,000,000 | 89,285,714 | Jun 07, 2018, 07:32 AM |
| MYOV | 10% Owner | Apr 02, 2018 | Buy | $20.27 | 1,110,015 | 22,500,005 | 38,341,357 | Apr 04, 2018, 04:51 PM |
| SCYX | Director | Sep 15, 2016 | Buy | $2.94 | 40,000 | 117,600 | 60,000 | Sep 16, 2016, 08:50 AM |
| SCYX | Director | Jun 24, 2016 | Buy | $2.39 | 20,000 | 47,800 | 20,000 | Jun 28, 2016, 07:53 AM |
| MDVN | Director | Jan 19, 2016 | Option Exercise | $3.37 | 75,000 | 252,525 | 141,156 | Jan 21, 2016, 05:45 PM |
| MDVN | Director | Jan 19, 2016 | Sale | $37.34 | 75,000 | 2,800,562 | 104,135 | Jan 21, 2016, 05:45 PM |
| CMRX | Director | Dec 29, 2015 | Buy | $7.08 | 10,000 | 70,846 | 10,000 | Dec 30, 2015, 02:33 PM |
| MDVN | Director | Sep 25, 2015 | Option Exercise | $4.69 | 71,980 | 337,766 | 138,136 | Sep 28, 2015, 07:14 PM |
| MDVN | Director | Sep 25, 2015 | Sale | $42.36 | 71,980 | 3,049,106 | 125,536 | Sep 28, 2015, 07:14 PM |
| MDVN | Director | Jun 04, 2015 | Option Exercise | $9.39 | 36,000 | 337,860 | 67,500 | Jun 08, 2015, 06:25 PM |
| MDVN | Director | Jun 04, 2015 | Sale | $117.43 | 36,000 | 4,227,478 | 50,900 | Jun 08, 2015, 06:25 PM |
| MDVN | Director | Feb 10, 2015 | Option Exercise | $9.39 | 36,000 | 337,860 | 67,500 | Feb 12, 2015, 04:21 PM |
| MDVN | Director | Feb 10, 2015 | Sale | $103.89 | 36,000 | 3,739,984 | 66,800 | Feb 12, 2015, 04:21 PM |
| MDVN | Director | Jan 27, 2015 | Option Exercise | $9.63 | 36,000 | 346,613 | 67,500 | Jan 29, 2015, 05:34 PM |
| MDVN | Director | Jan 27, 2015 | Sale | $105.32 | 36,000 | 3,791,392 | 50,300 | Jan 29, 2015, 05:34 PM |
| MDVN | Director | Dec 03, 2014 | Sale | $113.00 | 1,580 | 178,540 | 31,500 | Dec 04, 2014, 04:53 PM |
| MDVN | Chief Business Officer and CFO | Feb 18, 2014 | Option Exercise | $10.59 | 40,000 | 423,400 | 70,830 | Feb 19, 2014, 04:58 PM |
| MDVN | Chief Business Officer and CFO | Feb 18, 2014 | Sale | $82.79 | 40,000 | 3,311,646 | 67,230 | Feb 19, 2014, 04:58 PM |
| MDVN | Chief Business Officer and CFO | Feb 11, 2014 | Option Exercise | $10.59 | 40,000 | 423,400 | 70,830 | Feb 12, 2014, 05:34 PM |
| MDVN | Chief Business Officer and CFO | Feb 11, 2014 | Sale | $80.83 | 40,000 | 3,233,121 | 66,330 | Feb 12, 2014, 05:34 PM |
| MDVN | Chief Business Officer and CFO | Feb 05, 2014 | Option Exercise | $10.59 | 40,000 | 423,400 | 70,830 | Feb 06, 2014, 05:24 PM |
| MDVN | Chief Business Officer and CFO | Feb 05, 2014 | Sale | $73.46 | 40,000 | 2,938,574 | 55,430 | Feb 06, 2014, 05:24 PM |
| MDVN | Chief Business Officer and CFO | Jan 28, 2014 | Option Exercise | $10.59 | 40,000 | 423,400 | 70,830 | Jan 29, 2014, 07:33 PM |
| MDVN | Chief Business Officer and CFO | Jan 28, 2014 | Sale | $75.43 | 40,000 | 3,017,122 | 62,530 | Jan 29, 2014, 07:33 PM |
| MDVN | Chief Business Officer and CFO | Jan 21, 2014 | Option Exercise | $10.59 | 40,000 | 423,400 | 70,830 | Jan 23, 2014, 07:24 PM |
| MDVN | Chief Business Officer and CFO | Jan 21, 2014 | Sale | $76.29 | 40,000 | 3,051,627 | 45,644 | Jan 23, 2014, 07:24 PM |
| MDVN | Chief Business Officer and CFO | Dec 03, 2013 | Sale | $62.66 | 5,425 | 339,910 | 30,830 | Dec 04, 2013, 06:18 PM |
| MDVN | Chief Business Officer and CFO | Nov 07, 2013 | Option Exercise | $0.77 | 2,765 | 2,143 | 36,255 | Nov 12, 2013, 05:28 PM |
| MDVN | Chief Business Officer and CFO | Dec 10, 2012 | Option Exercise | $54.40 | 5,125 | 278,825 | 43,084 | Dec 11, 2012, 07:00 PM |
| MDVN | Chief Business Officer and CFO | Oct 01, 2012 | Option Exercise | $5.88 | 5,500 | 32,340 | 42,049 | Oct 03, 2012, 06:49 PM |
| MDVN | Chief Business Officer and CFO | Oct 03, 2012 | Option Exercise | $6.74 | 5,100 | 34,374 | 41,649 | Oct 03, 2012, 06:49 PM |
| MDVN | Chief Business Officer and CFO | Oct 02, 2012 | Option Exercise | $6.44 | 9,400 | 60,490 | 45,949 | Oct 03, 2012, 06:49 PM |
| MDVN | Chief Business Officer and CFO | Oct 03, 2012 | Sale | $51.08 | 5,100 | 260,483 | 36,549 | Oct 03, 2012, 06:49 PM |
| MDVN | Chief Business Officer and CFO | Oct 02, 2012 | Sale | $57.08 | 9,400 | 536,508 | 36,549 | Oct 03, 2012, 06:49 PM |
| MDVN | Chief Business Officer and CFO | Oct 01, 2012 | Sale | $57.04 | 5,500 | 313,739 | 36,549 | Oct 03, 2012, 06:49 PM |
| MDVN | Chief Business Officer and CFO | Sep 28, 2012 | Option Exercise | $56.35 | 6,473 | 364,754 | 36,549 | Oct 03, 2012, 04:52 PM |
| MDVN | Chief Business Officer and CFO | Sep 28, 2012 | Option Exercise | $56.35 | 6,473 | 364,754 | 15,038 | Oct 02, 2012, 05:39 PM |
| MDVN | Chief Business Officer and CFO | Sep 07, 2012 | Option Exercise | $11.76 | 20,000 | 235,200 | 41,511 | Sep 11, 2012, 04:53 PM |
| MDVN | Chief Business Officer and CFO | Sep 07, 2012 | Sale | $105.74 | 20,000 | 2,114,858 | 28,111 | Sep 11, 2012, 04:53 PM |
| MDVN | Chief Business Officer and CFO | Jul 02, 2012 | Option Exercise | $11.76 | 10,000 | 117,600 | 31,511 | Jul 05, 2012, 06:05 PM |
| MDVN | Chief Business Officer and CFO | Jul 02, 2012 | Sale | $94.11 | 10,000 | 941,100 | 21,511 | Jul 05, 2012, 06:05 PM |
| MDVN | Chief Business Officer and CFO | May 24, 2012 | Option Exercise | $11.76 | 9,400 | 110,544 | 30,911 | May 24, 2012, 07:13 PM |
| MDVN | Chief Business Officer and CFO | May 22, 2012 | Option Exercise | $11.76 | 600 | 7,056 | 22,111 | May 24, 2012, 07:13 PM |
| MDVN | Chief Business Officer and CFO | May 22, 2012 | Sale | $89.16 | 600 | 53,496 | 21,511 | May 24, 2012, 07:13 PM |
| MDVN | Chief Business Officer and CFO | May 24, 2012 | Sale | $89.17 | 9,400 | 838,213 | 21,511 | May 24, 2012, 07:13 PM |
| MDVN | Chief Business Officer and CFO | May 14, 2012 | Option Exercise | $11.76 | 10,000 | 117,600 | 31,511 | May 16, 2012, 05:25 PM |
| MDVN | Chief Business Officer and CFO | May 14, 2012 | Sale | $84.31 | 10,000 | 843,100 | 21,511 | May 16, 2012, 05:25 PM |
| MDVN | Chief Business Officer and CFO | Apr 27, 2012 | Option Exercise | $11.76 | 10,000 | 117,600 | 31,511 | May 01, 2012, 05:08 PM |
| MDVN | Chief Business Officer and CFO | Apr 27, 2012 | Sale | $80.16 | 10,000 | 801,630 | 21,511 | May 01, 2012, 05:08 PM |
| MDVN | Chief Business Officer and CFO | Mar 08, 2012 | Option Exercise | $11.76 | 10,000 | 117,600 | 31,511 | Mar 12, 2012, 05:11 PM |
| MDVN | Chief Business Officer and CFO | Mar 08, 2012 | Sale | $75.10 | 10,000 | 751,000 | 21,511 | Mar 12, 2012, 05:11 PM |
| MDVN | Chief Business Officer and CFO | Feb 07, 2012 | Option Exercise | $11.76 | 16,391 | 192,758 | 80,807 | Feb 09, 2012, 06:54 PM |
| MDVN | Chief Business Officer and CFO | Feb 08, 2012 | Option Exercise | $11.76 | 19,193 | 225,710 | 57,093 | Feb 09, 2012, 06:54 PM |
| MDVN | Chief Business Officer and CFO | Feb 08, 2012 | Sale | $69.06 | 57,093 | 3,942,916 | 37,193 | Feb 09, 2012, 06:54 PM |
| MDVN | Chief Business Officer and CFO | Feb 07, 2012 | Sale | $71.68 | 42,907 | 3,075,416 | 76,307 | Feb 09, 2012, 06:54 PM |
| MDVN | Chief Business Officer and CFO | Jun 01, 2011 | Sale | $24.15 | 28,200 | 681,030 | 58,861 | Jun 03, 2011, 06:26 PM |
| MDVN | Chief Business Officer and CFO | Feb 10, 2011 | Sale | $17.06 | 14,000 | 238,819 | 94,061 | Feb 11, 2011, 04:55 PM |
| MDVN | Chief Business Officer and CFO | Feb 09, 2011 | Sale | $15.55 | 2,800 | 43,530 | 101,061 | Feb 11, 2011, 04:55 PM |
| MDVN | Chief Business Officer and CFO | Feb 07, 2011 | Sale | $15.51 | 4,200 | 65,130 | 120,527 | Feb 08, 2011, 08:11 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| ADVM | Director | Mar 24, 2021 | Buy | 99,196 |
| ADVM | Director | Jan 15, 2021 | Buy | 115,174 |
| UROV | 10% Owner | Jun 19, 2019 | Buy | 40,495 |
| UROV | 10% Owner | Jun 18, 2019 | Buy | 55,061 |
| UROV | 10% Owner | Jun 17, 2019 | Buy | 55,825 |
| UROV | 10% Owner | Jun 14, 2019 | Buy | 56,514 |
| UROV | 10% Owner | Jun 13, 2019 | Buy | 58,543 |
| UROV | 10% Owner | Jun 12, 2019 | Buy | 62,244 |
| UROV | 10% Owner | Jun 11, 2019 | Buy | 61,694 |
| UROV | 10% Owner | Jun 10, 2019 | Buy | 62,594 |
| UROV | 10% Owner | Jun 07, 2019 | Buy | 52,959 |
| MYOV | 10% Owner | Jun 04, 2019 | Buy | 19,999,997 |
| UROV | 10% Owner | Jun 06, 2019 | Buy | 56,621 |
| UROV | 10% Owner | Jun 05, 2019 | Buy | 52,418 |
| UROV | 10% Owner | Jun 04, 2019 | Buy | 56,911 |
| UROV | 10% Owner | May 31, 2019 | Buy | 39,042 |
| UROV | 10% Owner | May 30, 2019 | Buy | 58,090 |
| UROV | 10% Owner | Jun 03, 2019 | Buy | 41,815 |
| UROV | 10% Owner | May 29, 2019 | Buy | 51,983 |
| UROV | 10% Owner | May 28, 2019 | Buy | 29,245 |
| UROV | 10% Owner | May 24, 2019 | Buy | 29,233 |
| UROV | 10% Owner | May 23, 2019 | Buy | 37,252 |
| UROV | 10% Owner | May 22, 2019 | Buy | 40,558 |
| UROV | 10% Owner | May 21, 2019 | Buy | 85,108 |
| UROV | 10% Owner | May 20, 2019 | Buy | 80,525 |
| UROV | 10% Owner | May 17, 2019 | Buy | 45,641 |
| UROV | 10% Owner | May 16, 2019 | Buy | 36,718 |
| AXON | 10% Owner | Mar 18, 2019 | Buy | 10,000,001 |
| ECYT | Director | Dec 21, 2018 | Option Exercise | 169,200 |
| AXON | 10% Owner | Dec 18, 2018 | Buy | 10,000,000 |
| UROV | 10% Owner | Oct 01, 2018 | Buy | 37,499,994 |
| AXON | 10% Owner | Jun 05, 2018 | Buy | 25,000,000 |
| MYOV | 10% Owner | Apr 02, 2018 | Buy | 22,500,005 |
| SCYX | Director | Sep 15, 2016 | Buy | 117,600 |
| SCYX | Director | Jun 24, 2016 | Buy | 47,800 |
| MDVN | Director | Jan 19, 2016 | Option Exercise | 252,525 |
| MDVN | Director | Jan 19, 2016 | Sale | 2,800,562 |
| CMRX | Director | Dec 29, 2015 | Buy | 70,846 |
| MDVN | Director | Sep 25, 2015 | Option Exercise | 337,766 |
| MDVN | Director | Sep 25, 2015 | Sale | 3,049,106 |
| MDVN | Director | Jun 04, 2015 | Option Exercise | 337,860 |
| MDVN | Director | Jun 04, 2015 | Sale | 4,227,478 |
| MDVN | Director | Feb 10, 2015 | Option Exercise | 337,860 |
| MDVN | Director | Feb 10, 2015 | Sale | 3,739,984 |
| MDVN | Director | Jan 27, 2015 | Option Exercise | 346,613 |
| MDVN | Director | Jan 27, 2015 | Sale | 3,791,392 |
| MDVN | Director | Dec 03, 2014 | Sale | 178,540 |
| MDVN | Chief Business Officer and CFO | Feb 18, 2014 | Option Exercise | 423,400 |
| MDVN | Chief Business Officer and CFO | Feb 18, 2014 | Sale | 3,311,646 |
| MDVN | Chief Business Officer and CFO | Feb 11, 2014 | Option Exercise | 423,400 |
| MDVN | Chief Business Officer and CFO | Feb 11, 2014 | Sale | 3,233,121 |
| MDVN | Chief Business Officer and CFO | Feb 05, 2014 | Option Exercise | 423,400 |
| MDVN | Chief Business Officer and CFO | Feb 05, 2014 | Sale | 2,938,574 |
| MDVN | Chief Business Officer and CFO | Jan 28, 2014 | Option Exercise | 423,400 |
| MDVN | Chief Business Officer and CFO | Jan 28, 2014 | Sale | 3,017,122 |
| MDVN | Chief Business Officer and CFO | Jan 21, 2014 | Option Exercise | 423,400 |
| MDVN | Chief Business Officer and CFO | Jan 21, 2014 | Sale | 3,051,627 |
| MDVN | Chief Business Officer and CFO | Dec 03, 2013 | Sale | 339,910 |
| MDVN | Chief Business Officer and CFO | Nov 07, 2013 | Option Exercise | 2,143 |
| MDVN | Chief Business Officer and CFO | Dec 10, 2012 | Option Exercise | 278,825 |
| MDVN | Chief Business Officer and CFO | Oct 01, 2012 | Option Exercise | 32,340 |
| MDVN | Chief Business Officer and CFO | Oct 03, 2012 | Option Exercise | 34,374 |
| MDVN | Chief Business Officer and CFO | Oct 02, 2012 | Option Exercise | 60,490 |
| MDVN | Chief Business Officer and CFO | Oct 03, 2012 | Sale | 260,483 |
| MDVN | Chief Business Officer and CFO | Oct 02, 2012 | Sale | 536,508 |
| MDVN | Chief Business Officer and CFO | Oct 01, 2012 | Sale | 313,739 |
| MDVN | Chief Business Officer and CFO | Sep 28, 2012 | Option Exercise | 364,754 |
| MDVN | Chief Business Officer and CFO | Sep 28, 2012 | Option Exercise | 364,754 |
| MDVN | Chief Business Officer and CFO | Sep 07, 2012 | Option Exercise | 235,200 |
| MDVN | Chief Business Officer and CFO | Sep 07, 2012 | Sale | 2,114,858 |
| MDVN | Chief Business Officer and CFO | Jul 02, 2012 | Option Exercise | 117,600 |
| MDVN | Chief Business Officer and CFO | Jul 02, 2012 | Sale | 941,100 |
| MDVN | Chief Business Officer and CFO | May 24, 2012 | Option Exercise | 110,544 |
| MDVN | Chief Business Officer and CFO | May 22, 2012 | Option Exercise | 7,056 |
| MDVN | Chief Business Officer and CFO | May 22, 2012 | Sale | 53,496 |
| MDVN | Chief Business Officer and CFO | May 24, 2012 | Sale | 838,213 |
| MDVN | Chief Business Officer and CFO | May 14, 2012 | Option Exercise | 117,600 |
| MDVN | Chief Business Officer and CFO | May 14, 2012 | Sale | 843,100 |
| MDVN | Chief Business Officer and CFO | Apr 27, 2012 | Option Exercise | 117,600 |
| MDVN | Chief Business Officer and CFO | Apr 27, 2012 | Sale | 801,630 |
| MDVN | Chief Business Officer and CFO | Mar 08, 2012 | Option Exercise | 117,600 |
| MDVN | Chief Business Officer and CFO | Mar 08, 2012 | Sale | 751,000 |
| MDVN | Chief Business Officer and CFO | Feb 07, 2012 | Option Exercise | 192,758 |
| MDVN | Chief Business Officer and CFO | Feb 08, 2012 | Option Exercise | 225,710 |
| MDVN | Chief Business Officer and CFO | Feb 08, 2012 | Sale | 3,942,916 |
| MDVN | Chief Business Officer and CFO | Feb 07, 2012 | Sale | 3,075,416 |
| MDVN | Chief Business Officer and CFO | Jun 01, 2011 | Sale | 681,030 |
| MDVN | Chief Business Officer and CFO | Feb 10, 2011 | Sale | 238,819 |
| MDVN | Chief Business Officer and CFO | Feb 09, 2011 | Sale | 43,530 |
| MDVN | Chief Business Officer and CFO | Feb 07, 2011 | Sale | 65,130 |